106
cytochrome P450 sequences from Trichoplax JGI Triad1 assembly
sorted into
clans
Clans
CYP2 (1 seq)
CYP3 (49
seqs)
CYP4 (27
seqs)
CYP7 (2
seqs)
CYP26 (1
seq)
CYP51 (2
seqs)
CYP74 (1
seq)
mito (21
seqs)
unassigned
(2 seqs)
D. Nelson
Jan. 30, 2008
CYP2 clan (1
seq)
>CYP2 clan.a e_gw1.8.275.1|Triad1 31% to CYP1A1 human,
31% to 1C2 danio,
32% to 1B1
danio
MQLSVCNVAIAIVAIGLLNYIWTVVQARTTLPSGPLPWPIVGNTFALSKLPELTLTEMRKRYGDVFTVFIGTRPCLIVNG
VNKVKEALLKNSVTFGGRPNLMLFKFFEIPNGPVGISATDYTPTLRLHRKVTHTAIRNYTQASGSDAAKFEQLVRGEINK
LIKVIEKHESKPFDVLPDLLNSVTFLIFTVCFGPDSFEKYIDRKSLEKLSAALTVFDEYISMNNIFDTFPFLYHLLMKIP
SKTNRELEALTNDLLSMLEKELETHKETYDPDTVRDILDAMIKAKREAEDEERDDKASMLDDYSLIGTIGDLFFAGMQTT
SYTVQWYLLFMITHPQIQKKVHDELDQIVGRNNYPAIENRSSLKFLDATISETLRLSSIVPLSLPHAPLKDIEIFGQKIP
KGTAVWVNLWSVHHDEALWPNAKQFQPQRFLDKNGDLIKSPNLIPFSVGTRTCIGESLARYELFMYISHLMNHFEFKMAE
SQESYDLQPRPGLVHGCKSYKLIATPRK*
CYP3 clan
(49 seqs)
>CYP3 clan.a fgeneshTA2_pg.C_scaffold_4000046|Triad1 almost
identical to 3 clan.t
MVFAIFSNPNVHNEFINETDYSCYADPDIAYEILVKQSENFINRIDLVPTSNRPVGLIDARDVTWKHARESLTPLFSPNK
LKAMSHFANEASNNLLEKVLHKIDNDDDTVNVRELFYSTAMDMSLSSLFGVKPNEEKKIELQTHINNFMGGLKKPIAALF
IALPKASRPLRVLFNYKQVKAIVKLATMLRKIVTTRRRELDQGLSTRTDMLKLVIEAEHKEKISDFDIVQHCLTFLIGGY
DTTASSLTFIAFALATNPDVQDKVIEEIDQYCPDEDNLNYNDIQKLDYLEMTINEAFRYFSAGYINLREAKSDCVINGVQ
FPKGVGIAIAVKAIHEDPDIWENPDKFDPQRFSADQKSKRHPCHFLPFSDGPRKCIGNRLGMMNLKLILVRLLQQVKFEV
ANQTENPLPTIVIFTAIPENPVILKVVRRV*
>CYP3 clan.t gw1.898.1.1|Triad1 almost identical to 3
clan.a
MDITLIILSSTFAVLLFTYIFYFYYLKPYSYFDKINIPGPKPKFIVGNLWDTVYVRRHLCLTDHVKKYGKIFGLYYGRKP
IIHVADPDIAYEILVKQSENFINRIDLVPTSNRPVGLIDARDVTWKHARESLTPLFSPNKLKAMSHFANEASNNLLEKVL
HKIDNDDDTINVRELFYSTAMDMSLSSLFGVKPNEEKKIELQTHINNFMGGLKKPIAALFIALPKASRPLRVLFNYKQVK
AIVKLATMLRKIVTTRRRELDQGLSTRTDMLKLVIEAEHKEKISDFDIVQHCLTFLIGGYDTTASSLTFIAFALATNPDV
QDKVIEEIDQYCPDEDNLNYNDIQKLDYLEMTINEAFRYFSAGYINLREAKSDCVINGVQFPKGVGIAIAVKAIHEDPDI
WENPDKFDPQRFSADQKSKRHPCHFLPFSDGPRKCIGNRLGMMNLKLILVR
>CYP3 clan.aaa gw1.4.1035.1|Triad1
IFYFYYLKPYSYFDKINIPGPKPKFIVGNLWDTVYARRHLCLTDHVKKYGKIFGLYYGRKPIIHVADPDIAYEILVKQSE
NFINRIKFGPTSKQPVGLIDARDVTWKHARESLTPLFSPNKLKAMSHFANEASSNLLEKVLHKIDNDDDTINVRELFYST
AMDMSLSSLFGVKPNEEKKIELQTHINNFLGGIRRPISVLFFALPNIYRFLSLFIAYKQVKGIIKASSMLREIVTARRRE
LDQGLSTRTDMLKLVIEAEHKEKISDFDIVQHCFTFLIGGYDTTASNLTFIAFALATNPDVQDKVIEEIDQYCPDEDNLN
YNDIQKLDYLEMTINEAFRYFSAGYISLREAKSDCVINGVQFPKGVGIAIAVKAIHEDPDIWENPDKFDPQRFSADQKSK
RHPCHFLPFSDGPRKCIGNRLGMMNLKLILVRLLQQVKFEVANQTENPLPTIVIFTAIPENPVILKVVRR
>CYP3 clan.b gw1.5.1054.1|Triad1
FVIYLIYRFLIAPYLNIKKLGLPFPRPRPMVGNLFDFGPGNQHVAQMEWGKRYGRVYASLFFQIPTIWIGDPDMIKSVMV
KEFSNFTNRFPVTKTLHPFDKSILELKDQDWKRMRNILIPTFTTSKLKLILPFISEASDILIDTLITADEEGKIIDLWQA
SGHYTMKVILATSFGIQIESEKQEEKLMNAAGALFRSDPGILQVLMIISPRVFSALEPKFGGPLVSSINYIIHLTKQVIN
ERRRNIHAGVTCRRDLIQQMIEAGDNDKLNDDEIIAQAFIFLTAGYETTQNTLAFACYLLGTNPRVQQKLIDEIDSKCPD
VNSVSYDIITNLPYLEMIVSETLRLYPPAHFINRDVKQDTTINGVHIPKGVMIGFPVYSIHHDPQFWSNPDDFIPERFMP
EEKVKLVPYSYIPFGGGPRNCIGMRLALLEVKLALVKLMQKVKFTTVKETEIPLKLKGLSSLSPLNGIRLGIDRR
>CYP3 clan.c e_gw1.898.5.1|Triad1
MLKLVIEAEHKEKISDFDIVQHCFTFLIGGYDTTASNLTFIAFALATNPDVQDKVIEEIDQYCPDEDNLNYNDIQKLDYL
EMTINEAFRYFSAGYISLREAKSDCVINGVQFPKGVGIAIAVKAIHEDPDIWENPDKFDPQRFSADQKSKRHPCHFLPFS
DGPRKCIGNRLGIMNLKLILVRLLQQVKFEVANQTENPLPTVVVFTAIPENPVILKVVRRV*
>CYP3 clan.d fgeneshTA2_pg.C_scaffold_4000049|Triad1
MPVLDNLNVRAVTVVATVSVSAYFIYRKIVEPLHYFEQIGIPGPTPVAFLGNLPDLEEGIHLAHVALKEKYGKVFGLIIG
RKPQIVVCDVNILQKILIENFNGFCNRRGFQLLPYDNLKYGVNTLRDREWRRVRSILMPAFTLESCEELAPIIAKSCNIL
LIKFLQASYTEQALNISSAMNQFATEITMVTLFGQPGKLQTSVNVRPDKLTIAINSIFRVPPMTSLLILAIPPLSSYLLK
INSTGFRYLESVCYRAIRRKRERIAEKMECQRDLLQLMLEADRNGKLNDTDIASQSLTYLLTSYHPLKNGLCFLVYLIAT
HKEVQNRLIREIDENLPNRELPTQKEISKLVYLDAVIKETLRLYPATFIYHREAVEDCSINGFFFPKEVTIAIPVYAIHR
DPEIWPNPSSFRPERFLSDDANSARHPCSYLPFGVGARACMATHFVTMIFKMMLVITLRSIKFKTVAETEVPLSTTSLAS
LQPMYDVYLGIERRVYVDSI*
>CYP3 clan.e e_gw1.4.1027.1|Triad1
MIYSHYKALRYFKELGIPGPKPWPLLGNIPAVMAIGDQNSAHLKFTNEYGKVFGMFYLSEPVIVVSEFDIVKKILIKDFH
AFPNRRLPFKLPLNSLSKAVAIARDQEWKRIRDILTPTFTGNKLRSSFLIVDDITTKLVQSLIDSSQKKEIVNIRKVLGE
FTMETMLSVAFGVQMLNSKLIHSAIQIFDRGQLRVLMSILSPTLLKVIRKSPFDFDAKYFQHLDRAARQVIKYRRQSDQP
ARRDLLQLMMEAENNGKLSDDEIIAQSMIFLLAGYDTTANTISFAVYLLATHPEIQDKLINEIDDALQTQADSFNYDKIH
ELKYLDMVVSETLRLYPTASTTIREVACDHTIDKYKFKKGGTVMISAYALHRNSKEWPDPEKFIPERFTQEEKQKRNPLS
YLPFGGGPRVCIGMRFALMEIKIALVRILQKVKFTVVKETEIPLQLRVGPTLSPKNGIKLGIEVRE*
>CYP3 clan.f fgeneshTA2_pg.C_scaffold_5000102|Triad1
MLYKIVVAPRLKLRKLGLPYPPPSPVIGNLNDFGPNSTHIAQIEWQKKYGDIYAVQFFHVPSIWISKPDILRQIMVKDFS
NFPNHFSFNQSLPPFDKTVAELRDHDWKRVRNILVPTFTTSKLRVVVPLIKQATSEFIQRLIEADTKGEKLDMWSSCGQL
SMKVILGTAFGVEIESKEQEEKLTKAAGVFFRTDDMSKLQTLLQFLVFTMPNVFKHIEPLLGGRFSNAVNYIVDITKNVI
RERRDNLAAGKPCRKDMMQHMIEAGGQDKLSDDEIVSQAVIFLLAGYETTQNALSFTIYALATNPEAQQKLIDEIDSHCL
DGDSINYDIISSMSYLDMVISETLRLYPPATITNRDVKKSTTIDGIFFPDDIMVGIPIYAIHHDARLWPEPERFKPERFT
PEAKANQHPFAYLPFGNGPRNCIGMRLALLEVKLALIKILQNVEFVAIKETEVPLKLRSINTLAPTNPIYLGIRKRF*
>CYP3 clan.g fgeneshTA2_pg.C_scaffold_5000091|Triad1
MIKIFDFLWLPQLSIQSFLFASFLGLITITLYRNFIVPYRKLSKLGINVSPPMPLLGNMLDYGSTNRHIAQVKRQELYGN
VCGTLFFHIPNLWVGDPEMLKIITVKEFSNFANRFSLTKPRPPFDKTVVQLKDQDWKRVRTILIPTFSTSKLKGIMPLIT
DAGDNLIKTMSKAEEEGRAIDMWRTCGVYTMKVILATVFGIDFESKEQEKKLTESAARLFRNTNGVIQFFSIFLTPLFRM
VEPLLGGNLVKSTIYLAKTAENVLRERRRNLKNGIPCRRDILQQMIEAGDGDKLTDEEIIAQAFIFLIAGYDTTANTLGF
ASYSLATNPDVQKKLRDEIDSLCPDANSIDYDTLFSLPYLDMVISETLRMYPPAYFVNREAKEDITINGLLVPKDIMVSF
PIYGIHHNPELWPKPNEFIPERFSPEEKAKQIPCSYLPFGGGPRNCVGMRLALLEAKLALVKIIQNFELKTVAETEIPLK
LRSGTTLSPFNGAYVGLTRRY*
>CYP3 clan.h fgeneshTA2_pg.C_scaffold_3000387|Triad1
MLEFIGISTHTVAIASITILSLIFAFYQYFVRPLYYFQKLNIPGPKPSLFFGTVFTKEYGGHLGQVRCIKKYGKFYSGLL
GLKPVVIISDPEMLKEVLVKQFSNFSNRFDVIPFDPAVSRNLLAIKDDDWKRIRSVLIPTFSATKLKQIEPIIIDACDTL
VGKIIKENRENGKVNIWKLCGEYSMEVIMAAAFGVHVADDARGQKVCKAAAIFFSSSDIALLIASVVPSLYHFLSFLTRN
RTNAVNHIVQVARAVIAERRRNLQNGLTNRRDLLQLMIEAAENGKLTDDEIVSQSFIFLLAGYETTSNALGYTSYLLALN
PQVQQRLIDEIDEKCPKGTNLTIELLSELPYLDMVFNESLRIYPPAYIVNRVTKHETVIDEVKIPQDMMVAIPIYGIHHN
DELWPDPEKFIPERFTPEEKAKRHPFAYLPFGNGPRNCIGMRLAITEAKLALIKILQNIVLEPVKETPIPLEVEPKFTLS
VANGVIIGVKER*
>CYP3 clan.i e_gw1.5.313.1|Triad1
MSGYLQSFCQLFCSIILILSLRFIYKNYLLPYWRIKRLGIPVAPPKPIIGNNFDYGSGNQHLAQLKRQEKYGSICGTLFY
HIPTIWVGDPEILKVITVSDFSTFPNRYDLNEPRPPFDKAIIQLKNQDWKRVRNILIPTFSASKLKSLMPILNDAGNDLT
VTLSKADQEGRPIDIWRTCGVFTMKVTLATVFGLEMDSKEQEKKMTEAASMFFRDITGVVQFLFIYLMPLVGLIEPLLGG
KIIESVRYLLKTVENVIQERRENIKAGIPCRKDILQQMIEAGDDDKLNDAEILAQAITFLVAGYDTTANTLGFTCYLLAT
HPEIQKKLRDEIDAKCPDLDSIEYDTLHDLPYMDMIISETLRLYPTAFFLNRDIKKDTTINGVHFTKDLMIGIPVYAIHH
NPKIWSNPEEFIPERFSPKEKAKHAPCSFLPFGNGPRNCVGMRLALLEAKLALVKIMQKFEMRAVPETEIPLTLRSGNTI
SPINGVVVGVSRRR*
>CYP3 clan.j fgeneshTA2_pg.C_scaffold_5000105|Triad1
MAEGIGSVLMSWVQSQSSTTLLFMVVICGFITLLVKDYVIPYRTILATGLKGPIPKPFIGNVFDYGGVCQHRGQLKRQEK
YGKIYTLLHYHIPTVYIGDPEIIKTIMVKEFSNFTNRFPVNKAHHPFDKTVVRADDDDWKRLRTLLIPSFSASKLKTNVP
FINNFTNDVIDKFLQAEHQVKSVDVWKTFGNLSMSTIIATVFGIEFKSKKHKEKVITAASALLRNQTNLLQLVLIYAYLA
LALWEPITGGKIIRSVYYLRDTIVGVIQERRKNLKQVHHNPELWPDADKFIPERFSSEKKARRHPYSYIPFGGGPRICIG
MKLALLEVKLALVKILHRVEFVTCKETKIPLKLRTGSTASPESGVYLKTRRRH*
>CYP3 clan.k e_gw1.5.1057.1|Triad1
MWGLPQLSIQSFLITSFLGCITIVLYRNFIAPYRRLSQLGLKISMPTPLMGNNLDYGSTNQHIAQIKRQEMYGKIWGTLF
FHIPTIWIGDPDILKSITVKEFSNFTNRFALNQPRPPFDKAVVQLKDQDWKRVRTILIPTFSTSKLKAIVPFVKGAGDDL
IQTLSTAEEKGRVIDIWRTCGVFTMKVILATAFGIDFESKEQEKKLTESAGVLFRDISGILQFLVIYFTPMFALLEPLLG
GKIVSSVKYLVTTTENVLKERRRNLKDGIPCRRDILQQMIEAGDNDKLTDEEIIAQAIIFLIAGYDTTANTLGFASYLLA
TNPDAQKKLRDEIDSLCPDANSIDYDTLFSLPYLDMVISETLRMYPPAYFVNREAKEDITINGLLIPKDIMVCFPIYGIH
HNPELWPKPNEFIPERFSPEEKAKQIPCSYLPFGGGPRNCVGMRLALLEAKLALVKIIQNFELKTVAETEIPLKLRSGTT
LSPFNGVYVGLSRRN*
>CYP3 clan.L fgeneshTA2_pg.C_scaffold_4000059|Triad1 4
aa diffs to 3 clan.m
MLSNLLNCVQDIWQIHSTAVLVAIFAALIIYIFYYRYITILQHFDKLGIPGPKPWPILGNIPEIARLGGQHLAHMYYTKK
YGKVVGLFYGTERLTLVSDYEIIKKILIKDFHLFPNRRLPIKFPFDYLDKMLAFSRDQEWKTIRDTITPTFSANKLKAVL
PIVDNSSRKLRSALISYAQQGEIIDARDVFGKFTMEVILSVAFGVQLNTQDTTLTNAASKMLSGIPRRILFTIISP
(small deletion)
YAPKSKDFLQLVLDGRESGKLSDDDIIAQSFIFLLAGYETTANTLSSVCYLLAVNPDVQERLINEVDDAFSGVDDDLSYEQIFE
LKYLDMVITETLRLYPPIPIIIREVAQDCTIGDYQFVAGTSIMLSTYALQRDSAEWPDPEKFIPERFTQEEKQKRSSMSY
LPFGAGPRICIAMRFALMEIKIALVTVLRTVKFIRVKETEVPLQLNAGITISPKNGIKIGLEERSSP*
>CYP3 clan.m e_gw1.4.1014.1|Triad1
MLSNLLNCVQDIWQIHSTAVLVAIFAALIIYIFYYRYITILQHFDKLGIPGPKPWPILGNIPEIARLGGQHLAHMYYTKK
YGKVVGLFYGTERLTLVSDYEIIKKILIKDFHLFPNRRLPIKFPFDYLDKMLAFSRDQEWKTIRDTITPTFSANKLKAVL
PIVDNSSRKLRSALISYAQQGEIIDARDVFGKFTMEVILSVAFGVQLNTQDTTLTNAASKMLSGILRRILFTIISP
SLLELIRKSPLDFEAKYFQQLDHAARQVIKERRQSS
APKSKDFLQLVLDGRESGKLSDEDIIAQSFVFLLAGYETTANTLSSVC
YLLAVNPDVQERLINEVDDAFSGVDDDLSYEQIFELKYLDMVITETLRLYPPIPIIIREVAQDCTIGDYQFVAGTSIMLS
TYALQRDSAEWPDPEKFIPERFTQEEKQKRSSMSYLPFGAGPRICIGMRFALMEIKIALVTVLRTVKFIRVKETEVPLQL
NAGITISPKNGIKIGLEERSSP*
>CYP3 clan.n fgeneshTA2_pg.C_scaffold_4000058|Triad1
MLSNLLKCIQDIWELHPTAVLVALIAFLIIYFFYHKYVTILQHFIKLGIPGPKPWPILGNVPEIGQLGGQHLAHMYYIKK
YGKVVGLFYGTEQITLVSDYEMIKKILVKNFHLFPNRRVPVKFPFDYLNKALTVVRDQEWKNIRDTITPTFSANKLKAVL
PIVDNSSQELRSALTSYARQGEIIDARKVFGKFTMEVILSVAFGVQLNTQDTALTDAASKLFSGVGTRVLLAIISPYLLE
LIRSSPLDFEAKYFRRLDRVARQIIKERRQSGAPERKDLLQLMLDAQQSGKLSDDDIVAQSFVFLLAGYETTASTLSFIS
YLLALNPDVQEKLINEIDDAFSRIDDDLSYEQIYDLKYLDMVIAETLRLYPPAPILMREAAQDCTIGDYQFIAGTSVLIP
TYALQRDSTEWPDPEKFIPERFTQEEKRKRNPMSYLPFGTGPRICIGMRFALMEVKIALVTVLRAVKFIRVKETEVPLHL
NAAITISPKNGIKIGLEGRCLP*
>CYP3 clan.o fgeneshTA2_pg.C_scaffold_3000386|Triad1
MVGLIDISTQTAAIAGVTILSLAYAFYQYFVQPLYYFQKLNIPGPKPSLFVGTAFNKETGGHLGQIHCIKKYGKVYGGLL
GVRPIMVIADPEMLKEVLVKQFSNFPNRYAVIPPAPEFSRNLLAIKDDDWKRIRNVLIPTFSATKLKQIEPIIIDACDTL
VGKIIKENRENGKVNIWKLCGEYSMEVIMAAAFGVHVTDKVRGQKICKAAAAFFGGSDVALLIASVVPSLYPFLSFLARE
RTNAVNHTVQVARAVIAERRRNLQNGLTNRRDLLQLMIEAAENGKLTDDEIVSQSFIFLLAGYETTSNALGYTSYLLALN
PQAQQRLIDEIDEKCPKGTNPTIELLSELPYLDMVFNESLRIYPPAYIVNRATKHETVIKGVKIPQGLIVAIPIYGIHHN
DELWPDPEKFIPERFTPEEKAKRHPFAYLPFGNGPRNCIGMRLAITEAKLALIKILQNVVLEPVKETPIPLEVEPKLTLS
VANGVIIGVKER*
>CYP3 clan.p fgeneshTA2_pg.C_scaffold_5000089|Triad1
MGWLPPISTPSILIASFLGLITLALYRYFIAPYRRLRQLGMKIPRPIPLLGNMFDYGPTNQHDAQVKRQQIYGNLYGTLF
FHIPTIWIGDPDILKSITVKEFSNFTNRFALNQPRPPFDKAVIQLKDQDWKRVRTILIPTFSTSKLKAIVPLIESAGDDL
IQTLSTAEEKGRVIDIWRTCGVFTMKVILATAFGIDFESKEQEKKLTESAGVLFRNINGVLQFLFVFFTPLFRLLEPLLG
GKIISSVKYLVTTTENVLKERRRNLKDGIPCRRDILQQMIEAGDNDKLTDEEIIAQAIIFLVAGYETTANTLGFASYLLA
TNPDAQKKLRDEIDSLCPDANSIDYDTLFSLPYLDMVISETLRMYPPAFFINREAREDITINGLLIPKDVMVGFPIYAIH
YNPKLWPKPNEFIPERFSPEEKAKQIPCSYLPFGGGPRNCIGMRLALLEAKLALVKIIQNFELKTVAETEIPLKLRSGAT
LSPLNGVFVGLSRRS*
>CYP3 clan.q fgeneshTA2_pg.C_scaffold_4000050|Triad1
MDASNGYLPNPTMMVIAVTVLLLGLAYIYFVAPLAFFKRLGIPGPKPTLMFGNLLQVGSGEHLLHLQWSQQYGKIFGLLF
GRLPVIFVADPDMIKAITVKYSQNFIDRWSICKPSPPLGLGLFSLNGQAWRRLHNMLLSVFNDAELKLTMPYITKSSSTL
VRKLHQSINHGKVIDLWQYLSPFSMEVILATSFGIKVSSQENPDQMTHQARQLYRNYNFRNLMLAILPPTLCNWLDQLFS
WNRISYLEQVLRKAVKERRQMLKEEHSKTYPDLLQAMLKIQDGDSLTDDEVIGQSIQFLLTGCETTASALAFTLYLLAMN
PDIQRELRSEIMQRYSINDIMTLDGVAKLKYLDRVISESLRMYPPTYFYVHQANAETMINGYVFPKGVGVAIPVYTVHHD
PEFWPEPDNFKPERFETNLNSKQHSHSYLPFGSGPRSCLGAKFALLQIKMALIKLLLTFRFYKIDQTEIPLQVKCGLVLS
PKNGIYLGIHKL*
>CYP3 clan.r gw1.251.3.1|Triad1 C-term frag
DFDIVQHCFTFLIGGYDTTASNLTFIAFALATNPDVQDKVIEEIDQYCPDEDNLNYNDIQKLDYLEMTINEAFRYFSAGY
ISLREAKSDCVINGVQFPKGVGIAIAVKAIHEDPDIWENPDKFDPQRFSADQKSKRHPCHFLPFSDGPRKCIGNRLGIMN
LKLILVRLLQQVKFEVANQTENPLPTVVVFTAIPENPVILKVVRR
>CYP3 clan.s e_gw1.5.1059.1|Triad1
MSINDILAKIWLPQTPLQQLIVAVVVVTCSYFYYKFFVAPVRRLRKIGLPFPAPTALTGNIFDYGPTKQHIAQLEWQKKY
GTRYATQFFKAPAVWIAEPELLKTIMVKDFSNFANRFSFNAALPYFNKTLLELKNQDWKRVRTILIPTFTASKLKLIVPL
IKDTADILIDKLIKADEKGENIDLWKASGMFSMKVILGTAFGLEFENEEQEVKLTNAAGLFFRQDFGIRQTIFQLIFFAS
AKLFLFLEPRCGGGNFCSSVRHIVEITKAVIKERRNNLAHDRPCRKDVLQYMIEADGSNQLSDDEMISQAFVFLVAGYET
TQNALTFACYSLATNPDIQRKLIDEIDSKFPISDSLDYNIVSEMPYLDMVIAETLRLYPPAITTNREVSQSMIIDGIHIP
KDVILAIPIYSIHRDPKYWHDPEQFIPERFTPEAKASRNPYAYLPFGIGPRNCVGMRLALLELKVALVKTLQNIEFFANK
ETEVPLKLKSLSTLSPVNPLYLGIRKRF*
>CYP3 clan.u e_gw1.5.1052.1|Triad1
MNWIPSASQIVQLIIVGLVWYLYKSWIRPYRLLKKLGLKVPFPKPIFGNLLDCHPSIQHLGQLKNQEKYGRVYGSLFFSI
PTILIGEPDLLKSVCVKDFSNFSDRYPLVDGIEPFDKTLLELKGTDWKRVRNILLPTFSASKLKAIMPFIDRAGDRLVAT
ILKADEEGQSIDLWRTCGKFTMEVILATAFGIEFESKEQEKKLTNAARALFDTSPGPLQFLLIFAPPLFRVLEPKLGGQF
MNSTHYLMKTCKQVIKERRRNMAEGIACRRDILQQMLEAGDSDKLNDQEVVSQALIFLAAGYETTANTLAFATHSLATNP
EIQQRVFDEISDKLSENDSLDYDSVGDLPYLEMVIAETLRMYPPIFLANRSIKEDMEIDGLQVSKEAMIGIPVYAIHHNP
KIWPEPEQFRPERFTSEEKSKRDPCTYLPFGNGPRNCIGMRLAMLEVKLAIVKILQKVELIVTKETDVPLQLKCGSTLSP
ANGVYVGFRKR*
>CYP3 clan.v e_gw1.1.1532.1|Triad1
LFMGVRGRYLLTDPDIIKEITVKQFSNFLNRSITFNTGFRFDLGLLILRDDHWKKVRNILTPNFTSNKMKNMRPLLDDST
RILMQKLDEATKTGEPVNIWEWFGTYTMQIIMATAFGTDVDSQTNSDNILNKRASQSLHLSPFAVISAVFLPALFPLMVR
LDRSFINGMGFIDNFADKVLSMRKKEVDSKRQDIMQIMIDASDESKKGSLTHDEAVGQIITVLLAGYETTNNALGYIAYL
LALHPEVQDKLINEIESAYNSTEIDYDIIMYKMAYLDMVISESLRLYPPVMSIGREIKEDCVIKGVKFLKGLTIGIPAYA
MHRDPEFWEEPEKFDPERFSEERKNSINTYAYLPFGIGPRACIGSRFALMEIKLCLVKVLMAYRFVTCPETQIPLQVKSA
GSLSPQNGIYLKIEKR*
>CYP3 clan.w fgeneshTA2_pg.C_scaffold_5000097|Triad1
MVVSLVYLLIYSLYKHYYLPYRVLQRTGLPFDRPTYLVGNKFDFDPSLLHERQLERQKKYGLVYGEFFFTVPTIFIADPE
IIKSIMVTHFSNFCNRFQAINLPSLFEKSILRIADEPWKRIRTTMVGSFSVAKLKCMQNLISDSCRILMARFEESFYESK
KIALIKPCEHFSMHILLAVAFGIEFESVKDERKITEAVNILFSNTPVGLRVVMMLSMRAWEALERLMGGNFQSSIDYLEK
IVMNVIKDRRNNIKLKKPCRQDILQLLIEAGDKGKLTDEEIVAQVFFLMAGGYQTTATTLMFALYSIATNSNVQEKLYDE
IQAKYDNSNCQVDYNFVSELPYLGMVIEETTRMYPPVIFPDRGVKEDIVINGLLIPKEVMIGFPTYAIHHNPDYWPNPEE
FRPERFSPEEKAKQIPFSYITFGDGPRQCLGVRLAKLEIRMAIVNILLKYELFPVKETEIPLKLKSLGTMIPANEIVLGL
KKR*
>CYP3 clan.x e_gw1.5.996.1|Triad1
MAWSSILFVQIILVCIVSSGFLLCYKLFIIPYVKMKKMNLKGPPFKPLIGNLLDYGITKQHIAQIKLREKYGDIYGTQFF
QIPTIWIGDPDILKMVMVKEFSNFPNRYSFAKALNPLDKGLPELKDQSWHRIRNVVLPTFSSSKLKLIYPYICEMGNHLV
ESLISNADGNGRAIEFCQPCSKFTIEIILATAFGIEIDNLAEKEKLTRATNIVFGSQPSALFLLLFTSVRLFKMIEPIFG
EGLASLEYITKVTTKIIKQRRRNMEAGIECRKDFLQQIIEAGDQDKLNDDEIVGQAFIFLTAGFHTISNTLSFACYLLAT
NPDKQQKLYQEIESIFSADQDIDYDTLFELSYLNMVVLETMRIYPAGFFINRDIKEDKTINGIHFAKGAMLAVPIYAIHH
NPKLWPDPDKFIPERFTEEEKVKRHPFSYIPFGDGPRNCIGMRLALLEVKLAVAKIVQKMELLTTEKTEIPLEMETGTNL
TAPNGIYLAVRKRH*
>CYP3 clan.y fgeneshTA2_pg.C_scaffold_5000103|Triad1
MAWYETILPSWRSPSTLTQSILISILGLVAYFSYKIYFIPKRSLKRLGIKHPSRSTPFFGNLLDYGATSAHIAQMEWQKQ
FGNVYATLFFHVPTIWVGDPEVLKSVLVKDFSNFANRKQLSKSPRPFNTTLLELRDMNWKRVRNILVPAFSASKLKAVIP
IIQQGSDEFVEKLLLSEESNQKLDIWHTSGQFSMKIILAAGFGIEFESHEQEERLIAAAGALFRDFTGPSQLLVVLSPTL
FDRLEPLIGNVVNSIKYITRITENVIQQRRQNLQNGIKCRKDIMQQMIEAGEDDKLNDEEIIGQAFLFLIAGYETTQNTL
AFACYSLATNPDVQQKLIDEIDSKCPDPNDLNYDVIGELPYLEMVVEETLRMYPPTYFVNRDVKSNITVKGFHIPKDTMI
GLPIYSIHHNSEFWPNHEQFIPERFTPEEKAKRNPYSYIPFGGGPRNCIGMRLALLEIKLALVKIIQNVEFYATKETEIP
LQLKTGVSLCPANGIYLGIRRRH*
>CYP3 clan.z estExt_fgeneshTA2_pg.C_50098|Triad1
MAIQDILVFLFVPQSITHFIELTAIIGLAILIYRIVIDPYRRLKKLGLAGPKFKPVIGNIADWGPTGQHLALLEWRKKYG
NVFATMFFGTPTVWIGEPNMVREVMVKSFSNFSNRFPPFGKPISPFDKGVLFLKDDDWKRVRNILITTFSASKLKQIVPL
MKDIDAKFIEELVETNQVDGKVNILDHAGYFSLEVVLAIIFGIEYESKEQKIKLARTAKDLVEPIQGFLLIIFLLCPSMW
KIIEPYFGTIVQSINKITDLTNEIVKQRRKNLNAGLPCRKDMLQLIVEAGDQEKLSDEEIISQAIIFFIAGYDTTSNTIA
YASYLLATHPEIQDKLYQEICTKCPDVNSIDYEILNNLTYLDMVISETLRLYPPGFFSNREVKKEVTIEGVRIPNDSIVG
IPIYTIHHNPQFWPDPEQFIPERFTPEEKAKRNPCCYLPFGDGPRNCVGMRLALLEVKLALVSLMQNLELKTVADTEVPL
KLKTGGTLTAANGIWLGLGTR*
>CYP3 clan.aa fgeneshTA2_pg.C_scaffold_5000108|Triad1
MIGLQLSTSQILLISGTIFAWFFYKAYIKPKRCLKNLGIRGPPPKPILGNLLDCKPALQHIAQIERQEKYGYVYGTLFFS
IPTIWIGDVDILKSVLIKDFPNFTNHFGIASNLEPFNKALLELKDSDWKRVRTILVPTFSVSQIKENFSFVDKAGEGIVA
LLLKAEKEGDSIDLRKVCGNFSMEILLATAAGMEFESKEQEKKLTAAASQVSSGAAGLMQLLLLFATPLFRILEPLSGGQ
FMNSLHYLTDTCRKVIKERREKMAAGIACRRDLMQQMIEAGDSDKLDDNEVVAQAVIFLVGGYETTANTLAFATYLLATN
PEVQNRLYNEIKTKLSDADPLDYDRVADLPYLEMVILETLRIYPPAFRLTRACKNNTTIDGHQISKEAMIAVPVYAIHHD
PKLWPNPEQFIPERFAPEEKSKRAACAYLPFGMGPRNCLGMKFALLKIKLALVKVLQSVELTVTEKTDVPLPIKCGITMA
PANGVHLGCKRR*
>CYP3 clan.ab e_gw1.251.7.1|Triad1
PTQKEISKLVYLDAVIKETLRLYPATFIYHREAVEDCSINGFFFPKEVTIAIPVYAIHRDPEIWPNPSSFRPERFLSDDA
NSARHPCSYLPFGVGARACMATHFVTMIFKMMLVITLRSIKFKTVAETEVPLSTTSLASLQPMYDVYLGIERRVYVDSI*
>CYP3 clan.ac e_gw1.42.7.1|Triad1
MDEQINYIDSGFLFGDQLFYPVAILLISSILAYFLYRNIIAPLYYFQRLGIPSPKQTPFFGHVLNINRDGFQHTYLNYTK
QMGPVYGLMFGRVPEMVISDLDMVKEITVKRFNQFINRAELINLPKESPFYDGLLRLRDHQWKRVRGLLVPTFSGAKMRQ
IITIMNNISQGLVDRLLQKCQQDGQIDIWQAYGQVTMQIILAIAFGVESHGHNGSDNLTKSARRITGVATRLIVLVPLFP
SFIVRLLLTLRGKGRDDATFLRDTAMKVIESRRAHGLSSRKDLLQLMIDAGDNGKLTDTEVIAQSIVFLIAGYETTSNAL
AFTSYLLALNPDIQDKLIKEIDEKCPDENAIDYDTISNLTYLDMVLDEAMRIYPPAFRFNREASEDITINNIFIPKGMTV
TIPIIAIHHDPKLWPNPDKFDPERFSAKAKAERNPYSYMPFGVGPRACIGMRLAVIEAKLILIRTLQQVRFTVVKETPIP
LKFRGGVVTSPKNGIRLGLTSRNV*
>CYP3 clan.ad fgeneshTA2_pg.C_scaffold_42000018|Triad1
MWQIVLLSAIVGLIIYMFYTHYILPLYHFKSKDIPHPKAKIVFGNVLDDWYHGSHVNQIRNIQNFGRVYGTLIGTVPIIW
ISDPDMIKEITTKKFHCFVNRHQDIPLTIDVLCYGIVIARDERWKRIRRILSPTFSTSKLKQALVVINDTSQQVVDNLIH
SLSSEECHQTQAINYTKMYTTAILKSTLANSFGVYSDITRDGKLGKAIHTIFHNQGSAVMLASISPFLTKYFAKLIPGTF
EAFNVLDDTVKQAIRARRKENPSNRRKDLLNLLLESQDSETLSEKEISAQATTFLLGGYESTRNTLIFATYLITTHPEIQ
QKLIDEIDSYSPDQESLTYDVISKLPYLDMVVSEVLRLYPSFPEISRDVEQDVTIAGVKLCKGDAIKIPVYGIHRDSEFW
PNPEKFLPERFSAESTQKRHNCCYLPFGLGPRSCIGLRLALFTIKVFLVKQLQQFEFKVCEQTVTSLEIEAKASLSPLSD
LFVQIVKRK*
>CYP3 clan.ae e_gw1.4.1023.1|Triad1
MDNSVYTTILGFTTASLLYYIYHYYVKPYSYFDKFNIPGPKPKYIFGNLFDSSYGHRHRCLNKYFKKYGKVVGLFYGQIP
IIHVADIDIVSEILLKQSDKFLNRVNLVPSFDRPVGLMEARDEDWKNARTSLTPLFSPTKLKAMSQFANNAGFNLLNKIL
ENTELRSAVLDMKKLFYSTAMEMSLTSMFGIEADEKKRDEFEAGFSDFITGLARPFSAWSIALPKVFILLSVFFARKQVF
GIVKTHSILQQIIKTRRQELQQGVTTRTDMLKLVIEAEHKDKITDRDIVQHCFTFLVGGYDTTAATLTYAVFSLATNPDV
QDKLIEEIDQHCPDVSNLTYNDVQKLTYMDMVLNETLRYYSPGYINLREAKEDCTIRGVRFPKGVGVAIAVKAIHEDPDV
WENPDKFDPERFSPEANANRHPCHFLPFSEGPRKCIGIRLGWMNMKLILARLLQRVKFDVAKETEIPLPTVIQFTVVPEN
PVYLKIVHRTQ*
>CYP3 clan.af e_gw1.5.1029.1|Triad1
MALQELLTSSISLREILLPIVMVLLCYGFIHKLYDDYYRPYRRLRKCGLKMPIPKPFAGNVMDYGSRDQHTAQIKRQELY
GNVYGTFIFCAPTIWIGDPEMLKAVMVKDFANFTNRYALVSLMRPFDKTLLRLTNKDWKRVRTTLVPTFSASKLKTILPF
IRVASDNLVDKLFQVEVNRKAVNIWQVCGQFTMRVILATAFGIEFESEEHEAKITKAAGMILRDTNTFVQFFVVYASPLF
KILEPVVGGDIMKSINLLTETIEQVICQRRKNLKEGIPCRKDILQHMIEAGNSDNISDEEIIAQAVIFLIAGHETTANTL
ALASYSLATNPETQEKLITEIDDKCPNASNLDYETLSTLPYLEMVISETLRMYPAGFFVNRCAKEDIIINGVDIPKNSMI
GLPIYAVHHNPQFWPDPECFIPERFTPEAKAKHHPYSYIPFGGGPRNCIGMRLALLETKFALVRILQNVKLVVVKETEIP
LKLKTGATLSPANGVYVGIQRRH*
>CYP3 clan.ag e_gw1.25.20.1|Triad1
MIGLQLSISQILLISGTILAWCFYKYYLKPYRHLRKLGLSGPRPKPLFGNLLDGKSASQHLVQVERQEKYGHVYGTLFFS
VPTIWIGDPEVLKSVLIKDFSNFTNRFGIANNLEPFNKTLVELRDTDWKRVRNILIPTFSTSKLKLTFPCVDKASNEIVV
MLLNAEKEGRSIELWRICGKFTMKVILASAFGIEFESKEQEKRLTGAASQLTSNSPGLLHILLLFATPLFRILEPLFGGQ
FMNSLNYLADTCRNVIKERRKNMSEGVSCRRDMLQQMIEAGDNDKLDDKEIIAQALVFLVGGYETTANTLAFATYLLATN
PEIQRRLYHEIKTKLNDTDPLDYDCVSDLPYLEMVILETLRIYPPAFRVTRKCKNDITIDGHQISKEAMIAIPIYAIHHN
PKLWPNPEQFMPERFTPEEKSKHAACAFLPFGNGPRNCIGKRLALLEVKLALVKILRSVELITTEETDVPLPLRCGITMS
PANGINLGCKRR*
>CYP3 clan.ah fgeneshTA2_pg.C_scaffold_5000129|Triad1
MPGLTFLQILSLAVVFLAYLVYKFIISPYLYLRKLGLGVPFPLDFLGNTTDLGPTKRHYNQLKRLEKYGRIHGTLFFHFP
AIWVGEPEVLQTILIKEFSNFTNRFAFTNTLKPFDKSLFDLQGADWKRVRTIVLPTFSTAKLKLTFAIINDAGDHLCERM
MTAEQEGRPIELRDCCGKFAMEVILGAIFGIEYESEEQERKVTEAAAGIFATESGFLQFLAIISPTLFRILEPMVGGKLI
YSIDYLMAVTKKVIEHRRKNLRAGVSCRGDILQLMIEAGDHDKLDNDEIIAQAFVFLVAGYETTANTLTFLSHILAVNSD
VQQKVYEEISSKYHEDIGIESLQDLPYLDMVIAETMRLYPAAYAVDRLARDEITIKGFRIPKGMMIGIPIYSLHHDPMLW
PDPEKFIPERFTPEEKAKRHPCSYLAFGNGPRNCIGMRFALLELKLAIVKIISRLELIMVKQTERRMETKTSTALLPAKP
VYVGIRRRH*
>CYP3 clan.ai e_gw1.5.986.1|Triad1
MVVEIANFLCLPQSILGKICLIFLCIAACILWYVYTSLIAPYCRLKRLGIDVPKPKLIVGNVTDFGPGNGHIAQLKRLQM
YGNIYGTLFFKVPAIWFNDPEMLRTVMVKEFSNFSNRYSLTKSLGPFSNSLQELKDDDWKRVRTILTTTFSSAKLKSIMP
IIDNASDDLIQSCDDAIAKGLPIDFWRQSGKFSMSVILATVFGIEIESQEQEEKLTEAAATLFRSLPGLLQFLIIFMPSL
FRILEPILGGKITYSMDYLTKTVKSVIKERRKSMVAGIPCRRDILQQMIEAGDNDKLSDDEIVSQAFVFLIAGYETTANT
IAFASYLIATNPEIQRKLHDEIDSNCPDTTSVNYDTLNNLPYLEMTISETLRLYPAGYMAHRDVRKDTTINGIRIPKGIM
AVIPIYAVHHNPQIWPNPEKFIPERFTPEEKIKHHPMAFIPFGGGPRNCIGTRLALLEVRAALVAILQNFQLLTVNETET
PLQITAGSTLSPANGILLGLKRR*
>CYP3 clan.aj e_gw1.3.357.1|Triad1
MEQISKTFDGNALVSTGTLAIIAVTCAVYLFYTSYVIPLKLFSKSGIKGPPPTLIVGNLSEFRKGLHDSLVNNRRKYGKV
FGTFLGTQPTLWVGDVDILKIIMVKEFHQFPDRVALTKTLPYPIKHSVLFARGEDWKRIRSILTATFSASKLKQIFYIVE
SACNRCVEKLEALSENEEIADMKVIYGNLTMEVIVASAFGVQLENDPRASKLINYANKIFNSVPTIQLIVALIPSFQPFF
RFFFRERQESTTYIANTVKGIIRERRESLKNGTRCNRDLLQLMIEASEDGKMSDDEIVGQAYIFLIAGYETTANTLTYAT
YLLANHPEVQDKLYKEIDKTYQDKGVIDYESVSELQYLDMVLSETLRIYPPAHAVNRGVSKDVTINGVKLLKSVPVGIPI
YGIHHDPDYWPNPEQFRPERFTPEEKQARNPSCYMPFGMGPRNCIGMRLALIEAKLALAKVVKAVEFSAIDKTEIPLKLK
AGVTLSPANPVYVGIKKRL*
>CYP3 clan.ak e_gw1.251.8.1|Triad1
MVLNETLRYYSPGYINLREAKEDCTIRGVRFPKGVGVAIAVKAIHEDPDVWENPDKFDPERFSPEANANRHPCHFLPFSE
GPRKCIGIRLGWMNMKLILARLLQRVKFDVAKETEIPLPTVIQFTVVPENPVYLKIVHRTQ*
>CYP3 clan.aL gw1.3.1180.1|Triad1
YQYFVRPLSYFQKLNIPGPKPSLFVGTAFSQEYGGHLGQINCIKKYGKVYGAFLGVKPVIVLTDPEMIKELMVKQFSNFP
NRYDVIPPPAAVNRNILVIRDDDWKRIRNILIPTFSAAKLRQIEPIMIDACDTLVDKIIKGNGQNGKVDMWRLSGEYSME
VIMAAAFGVHITDDVRGQKIRQAAATFFGGSGIALIIASIIPALYPYVSFLERERTDAVNHIVQVAKGVIAERRRNLQNG
LTNRRDLLQLMIEAAENGKLTDDEIVSQSFIFLLGGYETTANAIAYTSYLLACNPDVQQRLIDEIDEKCPKGTTPTSEII
SELPYLDMVFNESLRIYPPAFIVNRVAKHDAVIDGVKIPQDMMVAIPIYGIHHNDELWPDPEKFIPERFTPEEKAKRHSF
AHIPFGNGPRSCVGMRLAVTEAKLALIKILQNLILEPVKDTQIPLVVEPKLTLAPSKGVII
>CYP3 clan.am gw1.5.1020.1|Triad1
LLCTFVVKLYNDYVVPYKRLTKCGLKMPIPKPFIGNVLDYGSSEQHISQVKRQEQYGNVYGTFMFNAPTIWVGDPDMLKE
IMVKDFTNFTNRYSLSNTIKPFNKSLLQLDNKDWKRVRTTLVPTFSALKLKTILPFIKVASDDLVHKLMKAEAEGKAIDI
WQPYGRYTMQVILATAFGIEFESKEQEAKLTKAAGILFRETNSLVQFFVVFASRLFKIFEPVIGGGIMNSTRLLVTTVER
VIRERRKNLKEGIPCRKDILQQMIEANLNDEEIVAQAIVFLIAGHETTANTLAFASYLLMANPEAQEKLIAEIDDKCPDE
SSLDYETLSELPYLEMVISETLRIYPAGFFVNRKTKDDMVVNGIDIPKNSMIGLPIYAVHHNPQLWPDPERFIPERFTPE
AKAKRHPYSYIPFGGGPRNCIGMRLALLEAKLALVKVLQNVKLVAVKESEIPLRLKSGATLSPANGVYVGIQKR
>CYP3 clan.an fgeneshTA2_pg.C_scaffold_5000132|Triad1
MASYRFLSYLWLHQYASQTFAIIIILAFFRLLYTSYISPLWYLKKLRIKVPLPKPFIGNVTDEGGTNQHIAQVKRQERFG
TVNGTLFFHIPTIWIGDPNILKIVTVKEFSNFTNRFSFVKSRPPFDDSVLQLKDQEWKRVRNILLPTFSVSKLKAIVPLV
KDTCRSIIRTIAQAEEEQKSIDIWRECGKFSMKVMLVIAFGMDFKSEEQERKLTNAAAAQFRGAGSLKRLLIFICGPLYK
FLKPFVKNEFDDSLEYLTNTAKNVIKERRRNLKERIPCRNDILQQMIEAGDSDKLKNAEIVAQSVIFLTVGYETTANTLA
FACYLLAINPNVQKKLLEEIDTICPAIGGISYDALFDLQYLEMVIAETLRMYPPVYFVNRDVKETMVIDGVRIGRGVMLG
IPIYAIHHNPKLWPNPDQFMPERFSSKEKSKRHPYSYLPFGSGPRNCLGIRLAMLEVKIALVSILQNFELIISKDTVIPI
QVRTASTLSPANELNLGFRKRY*
>CYP3 clan.ao fgeneshTA2_pg.C_scaffold_3000549|Triad1
MVSFFWCTVIALIIFWFYVKFIVPLRYFKRLGIPGPSPIPIIGTLAADTKDGKGNHEVQQIHLEKYGRVYGFFVGSMPAY
VVGDLDIIKNILIKEFPAFSNRAMFFKTPGLEKSLANLRDTDWKRIRTVLNPTYTTSKMKQMFPLVNDSVDTFIRKMERV
ADKNQSIDVSDWLKQLSLEIITASAFGAKCNVQNGGHDRLINSATAIFKMNPTVIALSFMMPRLAPLFAAFDKSFMNGVK
YIDKAVASIIKMRRQEGATGANYKDLLQLMIDASAAAESNKSLTDNEIIAQSSTIMLAGYETTSSCATFTAYLLANNSEV
QDKLIHEIAKVCGKQEVTYDMLGQMTYLNKVIHESLRMYPPGYILLREATTTFQCNGYTFPKGIPIFIPAYALHHDNDIW
PEPYRFNPERFNKDLVEARHPCAYMPFGLGPRNCIETEIPIQVTAATTLAPKNSVYLRVMSHTS*
>CYP3 clan.ap fgeneshTA2_pg.C_scaffold_3000222|Triad1
MSTWTLAIIAVTCAVYLFYTSYVSPFKLFSKSGIKGPPPTLIVGNLSEFRKGLHDSLVNNRQKYGKVFGTFLGTQPMLWI
GDVDILKIIMVKEFHQFPDREALIKKLPYPFKHSVLFTSGEDWKRIRSILTATFSASKLKQIFYIVESACNRCVEKLEAL
SENEEIADMKVIYGNLTMEVIAASAFGVQLENDPRASKLINYANKIFDTAPTIQFILVLMPSFQPFLRFFLRERQESTTY
IANTVKGIIRERRESLKNGTRCNRDLLQLMIEASEDGKMSDDEIVGQAYIFLIAGYETTANTLTYATYLLANHPEVQDKL
YKEIDKTYQDKGVIDYESVSELQYLDMVLSETLRIYPPAHAVNRGVSKDVTINGVKLLKSVPVGIPIYGIHHDPDYWPNP
EQFRPERFTPEEKQARNPSCYMPFGMGPRNCIGMRLALIEAKLALAKVVKAVEFSAIDKTEIPLKLKAGGTLSPANPVYV
GIKKRL*
>CYP3 clan.aq e_gw1.4.467.1|Triad1 N-term
FAKRGIPGPKSSIIFGNLLDYQNKFELRYESVAINAKKYGKVIGCYYGKYPVLYIVDVDMVQKVLITQSKKFINRISLSS
ANRKSIGLFQACDEVWKRARDSLSPLFSSMNLNEMIAFTNKAGKKLSQIILEKSGQ*
>CYP3 clan.ar gw1.251.4.1|Triad1
IFYFYYLKPYSYFDKINIPGPKPKFIVGNLWDTVYARRHLCLTDHVKKYGKIFGLYYGRKPIIHVADPDIAYEILVKQSE
NFINRIKFGPTSKQPVGLIDARDVTWKHARESLTPLFSPNKLKAMSHFANEASSNLLEKVLHKIDNDDDTINVRELFYST
AMDMSLSSLFGV
>CYP3 clan.as fgeneshTA2_pg.C_scaffold_1000662|Triad1
MNATTSILITSAAVLLGYLFYKKFVKPLQHFSNHGIPGPKPIPLVGNILNGTLREGIHPGLLNLAAKYGDIFGFYFGPVR
VCYVGKPDVVKQILVKEFPKFTNKIGATTTTILDLNLESLRSLVKSSLGSRGMRECGEDCTIEGYHFSEGTSVVYPIYGX
HHDTRYWENPEDFDPERFSEERKNDIQPFTYLPFSTGPRVCIGMRLAMIEIKITLCYLLRRFRFIRAPETEVPVKLSVYA
TLCPANGIKIKVVDRKHS*
>CYP3 clan.at fgeneshTA2_pm.C_scaffold_3000065|Triad1
MWTFANITPQQIAWVAAVLILTLLFHYYFIHPLRYFKKLNIPGPKPYILIGSAFSKESKQINCIKKYGKVYGLLFGRRPV
MVISDLPMVKDIMVKHFSNFTNRFPIIPPTPPFHKNLLAITDDDWKRVRNVLIPTFSAAKLKQIESIISSACDSLFDKLM
NLNKQQGKANIWKIYGEYSMEVIMATAFGVHVTADVRGQEIRQQAASFFSTSNLAMALGAIMPSLYPYIKRRQSLQQGLT
NRRDLLQLLVEAGQNGKLTDEEIISQSFIFLLAGYETTASALAYTSYLLALNPDVQQRLLDEIDEKCPKGTTVTSELVSS
LPYLDMVLSESLRIYPPAYIVNRIAKNDIVIGGVLIPKDVVAAIPIYGIHHNEKLWPDPKKFIPERFTPEEKAKRHPFAH
LPFGNGPRNCIGMRLAIMEAKMALVKVLQDMMFEPVQETEIPLRIEPKITLSASNGVTLGIKER*
>CYP3 clan.au fgeneshTA2_pg.C_scaffold_5000098|Triad1
MDTLYIISAIFWFPSSWIQIVVISLFYSLIYSIFKHYCLPYRVLRRTGIPFDRPTYLVGNNFDFDPLTLHKRQLEQQKKY
GLVYGDFFFTIPTIFIADPEMIKSIMVTHFSNFCNRFQAINMPILFEKSILRIADEPWKRIRTVMIGSFSAAKLKPIGNL
VSDSCRILMISFDEGFHKNKKVSLTKPCEHLSMHVLLAAAFGIEFETLKDESKITEAVNVLFANMPVGLRMVMMLSIRLW
EFLEPLMGGKVLSSMDYLMQIVLNVINDRRNNIKLNKSCRQDILQMLIEAGDKGKLTDEEIVAQVFFLMVGGYQTTANTL
MFALHSIATNSNVQEKLYDEIQAKYDNNNCHIDYDFVLELPYLKMVLEETTRMYPPVIFPDRGVKEDITINGLLIPKEVM
IGFPTYAIHHNPDYWPNPEEFRPERFTVEEKAKQIPFSYITFGGGQRHCLGMRLAKLEVKMAIVNILLKYELFPVEETKV
PLEIKSEATLMPVEEIILGLKKR*
>CYP3 clan.av e_gw1.5.1033.1|Triad1
MNWIPSTSQILQLVLVGLAWYLYKSWIRPYRLLRKLGLKVPFPKPIVGNLMDYHPAVQHLGQLKNQEKYGRVYGGLFFSI
PAIWVSEPNLLKSVCIKNFSNFSDRYSLVNGIEPFGEMLLELKGTDWKRIRNILLPTFSASKLKAIMPFIDKAGDRLVAT
ILKAEQDGQSIDLWRTCGKFTMEVILATAFGIEFESKEHEEKLTNAARGLFEISPGPLQFLLIFAPSLFRVLEPKLGGQF
MNSTHYLVKTCKQVIKERRRNMAQGIACRRDILQQMLEAGDSDKLNDKEVVAQALLFLGAGYETTANALAFATHSLATNP
EIQQRVFDEISDKLSETDSVDYDSVGDLPYLEMVIAETLRMYPPVFHFNRDIKEDMEIDGLQVSKEAMIGIPVYAIHHDP
KIWPEPEQFRPERFTSEEKSKRDPCTYLPFGNGPRNCIGMRLAMVEVKLAIVKILQKVELIVTKETDVPIQLKCGTTLSP
ANGVHVGFRKR*
CYP4 clan
(27 seqs)
>CYP4 clan.a e_gw1.17.191.1|Triad1
MLSWIEAIFTIVIAFIVIIVIRNRGDIIQYFRIWKSLRKFPSPPSHWLMGHLLQLGKPDEACIQMLEKRCPSYDTCFVHW
FSIFPVLCCNNSDAAKDIIKASSPKGSWFYKLATPWLGHGLIAENGPRWARNRRLLTPAFHYDILKNYVRIYNDCIDTII
TKWKARDDKGESFDTYEDLKLLTLDVILQTAFSIKLDCQTIGKYHPYITASRQLTRLLLERVHFLPYSFDCIYRWSPSGK
KFLKLCHYVNQFSDEIISRRKETLTNNNINQQSSQNRRGKHMDFVDILLQTRDEDGYGLNVQEIRDEVNTFMFAGHDTTS
SALAWTLYCLAKYPQHQDKVREEADGILCDKDNIDYDDLHKLNYTHMCIKEAMRIYTPVPTIERKLNQDLTVNGMLVPAS
TTVFLQLHTLCRRSEVWPNPYQYDPQRFTAENIQNRDPYHYIPFSAGQRNCIGKNFATDELKIVVAKLVHHLQIEIDPKM
QPTRYYAMVNQPDKGIWLKIKRLK*
>CYP4 clan.b fgeneshTA2_pg.C_scaffold_5000148|Triad1
MKLPFLESSKLDYKYILFNSIICCIVGLFLQKLCKSVYKRLRLVYYGSKFNAPPHRFLIGNTHQLGGADKYFKFLIDTSK
IYDKYFMLWYGSTQPAFICYDPDVIKKVILAEPPKISNLYRFLSDWIGHGLLTSNGNHWARNRRLLTPAFHFDILKTYIN
IYNETADTLIEKWSASAERHEPLDLYYDASLCTLDVVLPCAFSMHLNCQTSGKNHPYINSVQTLGELIVKRGYNLLHHNP
WIYFNFTSAGKQFQQQVNVSHEFTEGIIRKRQAELENVGNDEVKSRKSLDFLDTLLNARYEDGTKLSLIDIRNEVDTFLF
AGHDTTAGTLSVTLYCLAKYPEHQSKIRDEVSNILQNKSQIEWDDLSQLKYTSLCIKEALRLFPPVPFNARTANKDLQID
GKIVPEGTIIIYSGFIVHRDPNVWDHPDEFDPSRFLPENIGDRHPFAYIPFSAGARNCIGQNFATNFLKIAIAKLVHRFD
FITDFKKEISYSAPLTLKLHNVEIYLRDRL*
>CYP4 clan.c e_gw1.11.37.1|Triad1
MGVNRIWSALKKVSGPKANWLSGNLDEIGSLEKYLSAVTNLCQKYPKMFPLWYGPTNPVLMISSPVVARQFNKSANTKEI
LVHRFTREWTGPGLLYSNGELWARNRKLLTPGFHFDVLKPYMVVYNECTDILIDKWVKLAEVGKPFEVLEDMCLLAFDII
VQCACSTQLNPQTHGSKHPFLVASRENTTLTEARLYNPLYASSFIYGLSSSGKKFYSNVAYSRQFAKEIIIQRKAALENQ
DNVNEHRKHLDFLDIMLTAQDSEGVGMTVDEIVYQVITFLFAGHDTTSSSLSWLLHSLAANPECQKKCREEVDNVLGSRT
NLEWQDLAQLKYLTLCIKESQRLHPTVPILGYTLGEEMTVEGYTFPKGMDIEFPSYVFHHDPNWWEEPWKFSPERFTAEN
SKGRDPYAFIPFAVGARNCIGQNFALQELKSVAAKILQRFELFTPNSSFHHIPSLVLKNKDGIWISLKERC*
>CYP4 clan.h e_gw1.824.1.1|Triad1 same seq as CYP4
clan.c (5 aa diffs in heme region)
MGVNRIWSALKKVSGPKANWLSGNLDEIGSLEKYLSAVTNLCQKYPKMFPLWYGPTNPVLMISSPVVARQFNKSANTKEI
LVHRFTREWTGPGLLYSNGELWARNRKLLTPGFHFDVLKPYMVVYNECTDILIDKWVKLAEVGKPFEVLEDMCLLAFDII
VQCACSTQLNPQTHGSKHPFLVASRENTTLTEARLYNPLYASSFIYGLSSSGKKFYSNVAYSRQFAKEIIIQRKAALENQ
DNVNEHRKHLDFLDIMLTAQDSEGVGMTVDEIVYQVITFLFAGHDTTSSSLSWLLHSLAANPECQKKCREEVDNVLGSRT
NLEWQDLAQLKYLTLCIKESQRLHPTVPILGYTLGEEMTVEGYTFPKGMDIEFPSYVFHHDPNWWEEPWKFNPERFTAEN
SKGRDPYAFMPFAVGTRNCIGQNFALQELKSVVAKILQRFELSTPNSSFHHIPSLVLKNKDGIWISLKERC*
>CYP4 clan.d e_gw1.11.340.1|Triad1
MNTLVLVLIAIAVAFLLKSAYSFFSRISNVWKALGKVPGPYAHWLTGTYIGTLETFIPAHSKLCEKYQDMFPMFYNVANF
QLCISNPILLKQFLKPSISKETIIHSFFEEWVGPGILQANGPQWSRNRRLLTPAFHFDVLKSYMKVFNECADILINKWVD
KAKDGKPIEILDDMSLCAFDAIIRCTCSTELNTQTHGSRHQFLIACRENTYLGESRIFNLFHHSSFLYKLSQNGRKFHRN
VAYCRQFARDIILRRKAELDSQEDNENKKHYDFLDIMLKAKDSDGTGMSVDEIVHEVITFLFAGHDTTSTSLSWLLFSLA
CNPQCQRQCQEEIRKVTEDRNDIRWDDLSALSYTTLCVKESQRLHTTVPFIGRTLGEETTVNGYTFPKGMDLELPIYHYH
HDSRWWKNPWDFDPSRFTPDNSQDRDPFCYLPFAVGTRNCIGQNFALQELKAIAAKILQRFELSTDNPTYQHIPAGVLKN
KGGIYLTLKDRK*
>CYP4 clan.e gw1.3.625.1|Triad1 44% to CYP4V
TFLFTGHETTSVSMTWTLYALASNPDVQEKVRREIRMVLEEHHLITLDVLEKLPYLENAIKESLRLFSPAPMTFRVAIND
DKIDKYDIPKGTVITIVPPHRYALPDYFPDPLQFNPDRWEDSNYTDKYSYVPFLAGPRTCIGNKF
>CYP4 clan.f e_gw1.7.637.1|Triad1
MLVGAEVVLGLFLSYIFYRSLCAIIGHYRIVNILKKFPGPKSHWLLGNLHQLASPKEFLKSYHSFSLKFPRKFLLWYGPL
TPVLSVSHPETIRAVIKAKTIKDGPAYQYFIAYRFLNEWVGPGLLTENGKRWSRNRRLITPAFHFDVLKPYVHIYNEALD
ILTEKWSNPDRLHKPLDTFYDASLCTLDVITRCAFSVEFDCQRENVKHPYINAVRTITKLVTERPFNIFYHSDWIYSITS
AGRKFYSNVQLTHEFTENVIRKRQGELSSSHDDGSKMKKHLDFLDVLLKATYENGEGLSLLEIRNEVDTFLFAGHDTSSS
ALSSTLYCIARYTEHQDKIRSEVDKILACKEEIEWKDLPELKHTSLCIKEAMRLYTTVPIIERTLERDVEIDGKILAAGS
QIAIAGFMLHRNPDVWDDPEKYDPLRFLPENCGSRHPYAYIPFSAGSRNCIGQNFAINFLKVAVAKLVYRYYFTVDMKNN
LTFTAPLVLKLHGHDIYIKERNN*
>CYP4 clan.g e_gw1.17.36.1|Triad1
MSILVVTLTLIIGYLAIVFIQKRKAIVQHLRIRRALEQFPCPPKHWLLGNLVLLGKPDERHIQLKEHYVKSFKTCSVYWL
SIFPILSINHSKAAKAIIKASVPKGSWIYAWVRPWLGRGLIFENGNRWKRNRRLLTPSFHYERLQSYLTVFNQCTDTIIQ
KWTERSQNNQSFNEFEDLTLLSFDSLLQCAFSVKIHCQTSGKNHPYVAAIHRLTRLITDRAFTLLHYIEWIYRLSSKGRE
FSQLCHFVHQFVEEIIEKRKKELENQEQNNRKEHYDFLDVLLTGRDEDGNGLTVQEIRDEVDTFMFAGHDTTASALSWTF
YCLAKYPHYQEKVRREVDVFMSHKNDVEWNDLSEMNYTTMCIKEALRLYTVVPVVERRMDQDMIIDGKLVPSGTIINLEL
YCICHREESWPNPNDYDPDRFSIENINNRDAFEYLPFSAGQRNCIGQQFAMNEIKVVVAKIIHHFYLEIDPNYDVKPYHS
IVNQTETGLWIKAKKRYF*
>CYP4 clan.h e_gw1.824.1.1|Triad1
MGVNRIWSALKKVSGPKANWLSGNLDEIGSLEKYLSAVTNLCQKYPKMFPLWYGPTNPVLMISSPVVARQFNKSANTKEI
LVHRFTREWTGPGLLYSNGELWARNRKLLTPGFHFDVLKPYMVVYNECTDILIDKWVKLAEVGKPFEVLEDMCLLAFDII
VQCACSTQLNPQTHGSKHPFLVASRENTTLTEARLYNPLYASSFIYGLSSSGKKFYSNVAYSRQFAKEIIIQRKAALENQ
DNVNEHRKHLDFLDIMLTAQDSEGVGMTVDEIVYQVITFLFAGHDTTSSSLSWLLHSLAANPECQKKCREEVDNVLGSRT
NLEWQDLAQLKYLTLCIKESQRLHPTVPILGYTLGEEMTVEGYTFPKGMDIEFPSYVFHHDPNWWEEPWKFNPERFTAEN
SKGRDPYAFMPFAVGTRNCIGQNFALQELKSVVAKILQRFELSTPNSSFHHIPSLVLKNKDGIWISLKERC*
>CYP4 clan.j e_gw1.11.38.1|Triad1
METNRIWVALRKVPGPKAHWLLGNLDDVGTLEDYLEGLTKLCQAYPNMFPIWYGITNPTLVLSSPLVAKKFIKPCNTKET
VVQRIYKEWTGSGLLFTNGKQWSRNRKLLTPGFHFDILKTYLVVYNECIDILMNKWSKLAVESKPFEVREDMSLCTFDII
LQCACSTKLNPQAEGFRHRFLTACHENSLFVEARAQNPLYVSKLIYKLTTEGKKFYSNVHYCKQFAKEIILERQADLENQ
DGINEERKHLDFLDILLTAKDSDGVGMTLDEMADEVITFLFAGHDTTSTSISWLLYSLASNPDYQKKCQEEIDNVLGDRT
EIAWEDLSSLPYLTLCIKESQRLHTTVPLLGYTLAEGMTVGGVKFPKGMDIEVPAYVYHHDSRWWKDPWTYDPLRFTPEN
SNSRDAYVYIPFAIGSRNCIGQNFAFQEVKAVAARILQRFDIATNQTTFKHIPGGVLKSQNGIWISLKERK*
>CYP4 clan.L fgeneshTA2_pm.C_scaffold_7000003|Triad1
MHFQLPHRCLSVFCLQLNQFPSPQGHWLYGSLSEMQNPDNILSYLQKQCQNYPSSFFLRLGPFMSILVCNSPDAAKAVIA
SGGAKENYSYTFIREWLGDGLLISNGGKWARNRKLVTPAFHFGVLKHYLPIYNRCVDVVIEKWSSQAATGQSFEIYSDMN
FLTLDIILQSSFSLKTQCQTIGKNDPYVTVVKELAWLTVNRFFSLTGYIPFLYYLTSEGRRFNTCVKESHRFTENVIRKR
LREVELGSESNVRDYIDFLDILIKARDRDGKGLSFNNIRNEVETFMFAGHDTTSSALSFTIYLLSKHKEHQQKVRDEVKS
VLQGRSDIAWNDLSELKYTTICIKEAMRLYTTVPMIERVLDKDVKIDGITVLAGTKINIPIFVLHGKANTWLNRDEYNPS
RFLSEEIAQRDAFSYIPFSAGSRNCIGQSFAMNVLKVAVAKIVRHYHLEIDETKPVVTTIPLVMKSATGIWIKVNEL*
>CYP4 clan.m e_gw1.31.39.1|Triad1
MIASLIIIVFITYAIVSLWPWLYSKYRIYSALRKMQGPKPHWITGNVSDFDGSFSQSLLKIDRQYSRKYALYYGIWHPVL
AINHPDTIRMALKKPFSKDTDAMKYVRDWTGDGILTSNGALWARNRRLLTPAFHFDVLRSYVSIYNECTDILIEKWKNNC
GKCIEIFDDMSRLTFDVLLRCAFSANLNLQTSEKRHPFLLATDENSYIVEERFVNLIYSITSTFKLTAKGRQYFKNTEFS
RKFAKEILMDRRKQIQTGQADTSNKKYLDFLDIMLQAKDSSGNGLTDDEIVAEAITFLFAGHDTTASTISFALFSLAKHP
EYQQKIREEYEQVLNGKDELSWGDLAGLQFTTMCIKETLRIHPPVCILGRGLCEDTEIDGQVFPKGLELELQLYCIHHNP
EFWPDPWTFNPLRFTQEEINKRDPYTFFPFALGSRNCIGQNFAMNEAKVTLAKLVHQFEFSEAENHPLDHLISSVLRNVG
GTWVQLKDRNP*
>CYP4 cla