Rhesus monkey P450s (Macaca mulatta)

(in progress, 49 seqs so far)

Jan. 27, 2006

The sequences are shown followed by a blast alignment of the Macaca seq on top compared to the human sequence below. At the bottom of this file a FASTA format collection of the rhesus P450s is given. One surprise finding is that two pseudogenes in humans are not pseudogenes in rhesus monkey. CYP2G2P and CYP1A8P are both full length intact genes.

>CYP1A1 AY635458.1

MLFRISMSATEFLLASLIFCLVFWVIRASRPRVPKGLKNPPGPW

GWPLIGHILTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVQQGDD

FKGRPNLYSFTLISNGQSMSFGPDSGPVWAARRRLAQNGLKSFSIASDPASSSSCYLE

EHVSKEAEVLISKLQEQMAGPGHFNPYRYVVISVANVICAICFGQRYDHNHQELLSLV

NLSNNFGEVVGSGNPADFIPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKG

HIRDITDSLIEHCQEKQLDENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLV

TNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR

DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFITPDGAIDKVLSEKVILF

GLGKRKCIGETIARWEVFLFLAILLQRVEFSVPPGVKVDMTPIYGLTMKHACCEHFQM

QLRS

>CYP1A2 (Aggarwal)

MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG
QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP
ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDK (0)
NSVQDITGALFKHSKKGPRASGNLIPQEKTVNLVNDIFGA (1)
GFDTIATAISWSLMYLVTKPEIQRKIQKEL (1)
DAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFTIPH (2)
STTRDTTLNGFYIPRECCVFINQWQVNHDP (2)
QLWGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE FSVPPGVKVDLTPIYGLTMKHARCEHFQAR
 
>CYP1A2 NM_000761
 Length = 515
 
 Score = 968 bits (2503), Expect = 0.0
 Identities = 472/510 (92%), Positives = 493/510 (96%)
 
Query: 1 MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
 MALSQSVPFSATELLLASAIFCLVFWVL+G RPRVPKGLKSPPEPWGWPLLGHVLTLGKN
Sbjct: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
 
Query: 61 PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG 120
 PHLAL+RMSQ YGDVLQIRIGSTPVLVLS LDTIRQALVRQG+DFKGRPDLY+ T ITDG
Sbjct: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120
 
Query: 121 QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180
 QS++FS DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM
Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180
 
Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP 240
 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKN+HEFVE+ASS NP+DFFP
Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240
 
Query: 241 ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDKNSVQDITGALFKHSKKGPRASGN 300
 ILRYLPNPALQRFKAFNQRF FLQKTVQEHYQDFDKNSV+DITGALFKHSKKGPRASGN
Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300
 
Query: 301 LIPQEKTVNLVNDIFGAGFDTIATAISWSLMYLVTKPEIQRKIQKELDAVIGRGRRPRLS 360
 LIPQEK VNLVNDIFGAGFDT+ TAISWSLMYLVTKPEIQRKIQKELD VIGR RRPRLS
Sbjct: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360
 
Query: 361 DRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTTLNGFYIPRECCVFINQWQVNHDPQL 420
 DRPQLPYLEAFILETFRHSSF+PFTIPHSTTRDTTLNGFYIP++CCVF+NQWQVNHDP+L
Sbjct: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420
 
Query: 421 WGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE 480
 W DPSEFRPERFLTA+GT INKPLSEK+MLFG+GKRRCIGEVL KWE+FLFLAILLQQLE
Sbjct: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480
 
Query: 481 FSVPPGVKVDLTPIYGLTMKHARCEHFQAR 510
  FSVPPGVKVDLTPIYGLTMKHARCEH QAR
Sbjct: 481 FSVPPGVKVDLTPIYGLTMKHARCEHVQAR 510

>CYP1A8P ortholog possibly a functional gene in rhesus

MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL

TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL

SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN

GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR

YLPLQIINAPREFYRALNGFIALHVQDHLATYDK (0)

DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVNDLFGA (1)

GFETVSTCLYWSFLYLIHYPEIQAKIQEEI (1)

DGNIGLKPPRFEDRKILPYTEAFISEVFRHASFLPFTIPHC (2)

TTADTTLNGYFIPRKTCTFINMYQVNHDE (2)

TIWDNPSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQL

KLKKCPRAKLDLTPTYGLVMRPKPYQLEAERRSSGSSSA

>CYP1A8P NT_008580.9|Hs9_8737 chromosome 9 Pseudogene 43% to 1A2

Length = 508

Score = 940 bits (2430), Expect = 0.0

Identities = 472/510 (92%), Positives = 486/510 (95%), Gaps = 2/510 (0%)

Query: 1 MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL 60

MIL+LAVTPGEVTTSLIILVMVFVFVRALRSKGRKQ+SPPGP SFPII NLLQLG+HPYL

Sbjct: 1 MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPYL 60

Query: 61 TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL 120

TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVL KDGEHFAGRPNMHTFSFLAEGKSL

Sbjct: 61 TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKSL 120

Query: 121 SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN 180

SFSVNYGESWKLHKKIASKAL T SNAEAKSSTCSC LEEHVTEE+SELVTVFVEL+SKN

Sbjct: 121 SFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSKN 180

Query: 181 GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR 240

G FDPRNAITC VAN+VCALCFGKR DHSDEEFL+IVKTNDDLLKASSAANPADFIPCL

Sbjct: 181 GSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCLH 240

Query: 241 YLPLQIINAPREFYRALNGFIALHVQDHLATYDKDHIRDITDALINVCHNKYAATKTDTL 300

YLPL+IINAP EFY+ALNGFIALHVQDHLATY KDHIRDITDALINVCHNKYAATKTDTL

Sbjct: 241 YLPLKIINAPLEFYQALNGFIALHVQDHLATYGKDHIRDITDALINVCHNKYAATKTDTL 300

Query: 301 NDSEIISTVNDLFGAGFETVSTCLYWSFLYLIHYPEIQAKIQEEIDGNIGLKPPRFEDRKILPY 360

NDSEIISTV+DLFGAGFETVSTCL WSFLYLIHYPEIQA+IQEEI +PPRFEDRKILPY

Sbjct: 301 NDSEIISTVSDLFGAGFETVSTCLCWSFLYLIHYPEIQARIQEEI------RPPRFEDRKILPY 358

Query: 361 TEAFISEVFRHASFLPFTIPHCTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNPSLF 420

TEAF+SEVFRHASFLPFTIPH TTADTTLNGYFIPRKTCTFINMYQVNHDETIWDN SLF

Sbjct: 359 TEAFVSEVFRHASFLPFTIPHSTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNHSLF 418

Query: 421 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQLKLKKCPRAK 480

RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFIT VLQQ KLKK PRAK

Sbjct: 419 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFKLKK*PRAK 478

Query: 481 LDLTPTYGLVMRPKPYQLEAERRSSGSSSA 510

LDLTPTYGLVMRPK YQL+AE SGSSSA

Sbjct: 479 LDLTPTYGLVMRPKLYQLQAELHPSGSSSA 508

>CYP1B1

MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI

GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF

ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL

LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA

EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIR (2)

YPDVQARVQAELDQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTS

VLGYHIPKDTVIFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKR

RCIGEELSKMQLFLFISILAHQCNFRANPNGPEMNFSYGLTIKPKSFKVNVTLRESMELL

DSAVQKLQAEETCQ

>CYP1B1 NM_000104

Length = 543

Score = 1021 bits (2639), Expect = 0.0

Identities = 509/543 (93%), Positives = 519/543 (95%), Gaps = 1/543 (0%)

Query: 1 MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI 60

MGT LSP DPWPLN LS QQTTLLLLLSVL VHVGQ LLRQRRRQL S PPGPFAWPLI

Sbjct: 1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

Query: 61 GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120

GNAAAVGQA+HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F

Sbjct: 61 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

Query: 121 ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL 180

ASFRV+SGGRSMAFGHYSEHWKVQRRAAHS MRNF TRQ RSRQVLEGHVLSEARELVAL

Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

Query: 181 LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

LVRGSADGAFLDPR LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

Query: 241 VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA 300

VDVMPWLQYFPNP+RT FREFEQLNRNFSNF+LDKFLRHCESLRPGAAPRDMMDAFILSA

Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA 300

Query: 301 EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIRYPDVQARVQAEL 360

EKKAA DS GGARLDLENVPAT+TDIFGASQDTLSTALQWLLLLF RYPDVQ RVQAEL

Sbjct: 301 EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL 360

Query: 361 DQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTSVLGYHIPKDTVI 420

DQVVGRDRLPCM DQPNLPYVLAFLYEAMRFSSFVPVTIPHAT ANTSVLGYHIPKDTV+

Sbjct: 361 DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV 420

Query: 421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480

FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL

Sbjct: 421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480

Query: 481 FLFISILAHQCNFRANPNGP-EMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAEE 539

FLFISILAHQC+FRANPN P +MNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQA+E

Sbjct: 481 FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE 540

Query: 540 TCQ 542

TCQ

Sbjct: 541 TCQ 543

>CYP2A23 AY635459.1

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMYNSIMKISERYGPVFTIHLGPRRIVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWLFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTQGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSAGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNRRTLDPNSPRDFIDSFLIRMQ

EEEKNPNTEFHLKNLVLTSLNLFFGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV

IGKNRQPKFEDQARMPYMEAVIHEIQRFGDMLPLGVAHRVIKDTKFRDFFLPKGTEVF

PMLGSVLKDPKFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF

LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPPNYTMSFLPR

>CYP2A24 AY635460 (Y. Peng)

CYP2A6 best match = CYP2A24 (Y.Peng) partial 

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMCNSLMKISERYGPVFTIHLGPRRVVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLGMMLGSFQFTSTSTGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQHTLDPNSPRDFIDSFLIRMQE

EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVE (1)
AKVHEEIDRVIGKNRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPK (0)
GTEVFPMLGSVLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSI (1)
GKRNCFGEGLARMELFLFFTTIMQNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR
 
Score = 1078 (379.5 bits), Expect = 1.2e-114, P = 1.2e-114
 Identities = 204/217 (94%), Positives = 209/217 (96%)
 
Query: 2 EEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGK 61
 EEKNPNTEFYLKNL+MTTLNLFI GTETVSTTLRYGFLLLMK+PEVEAKVHEEIDRVIGK
Sbjct: 1 EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVEAKVHEEIDRVIGK 60
 
Query: 62 NRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGS 121
 NRQPKFEDR KMPYMEAVIHEIQRFGDVIPMSLARRV KDTKFRDFFLPKGTEV+PMLGS
Sbjct: 61 NRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPKGTEVFPMLGS 120
 
Query: 122 VLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVM 181
 VLRDP FFSNPQDFNPQHFL+EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTT+M
Sbjct: 121 VLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTIM 180
 
Query: 182 QNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 218
 QNFR KS Q PKDIDVSPKHVGFATIP NYTMSFLPR
Sbjct: 181 QNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR 217
 

>CYP2C43 AB212264.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKLPPGPTPLPVIGNILK

IGIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

FERANRRFGLVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKFNENAKILSSPWIQIYNN

FSPIIDYFPGTHNKLLKNIAFVKSYILEKVKEHQESMDMNNPRDFIDCFLIKMEKEKH

NQQSEFNIENLENTAVDLFAAGTETTSTTLRYALLLLLKHPEVAAKVQEEIEHVIGRN

RSPCMQDRSRMPYTDAVVHEIQRYIDLLPTSVPHAVTCDVKFRNYLIPKGTTILISLT

SVLRDNKEFPNPEMFDPRHFLDEGGNFKNSNYFMPFSAGKRICVGEALARMELFLFLT

SILQNFNLKSLVDLKDLDTTPVFNGFVSVPPIYQLCFIPV

>CYP2C74 variant (S.Sarva) missing exon 1, 4 aa diffs to 2C74
FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGL (1)
GIISSNGKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTK (1)
ASPCDPTFILGCAPCNVICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQ (0)
VCNNFPLLIDCFPGTHNKLLKNVALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQ (0)
EKDNQQSEFTIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT (1)
AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQRYIDLVPTGVPHAVTTDIKFRNYLIPK (0)
GTIIITLLTSVLQDDKEFPNPKIFDPGHFLDENGNFKKSDYFMPFSA (1)
GKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGIISLPPSYQICFIPV

>CYP2C8 M17397
 Length = 490
 
 Score = 823 bits (2126), Expect = 0.0
 Identities = 398/434 (91%), Positives = 413/434 (95%)
 Frame = +1
 
Query: 1 FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGLGIISSN 180
 FSKVYGPVFTVYFGMNP+VV HGYE VKEALIDN EEFSGRG PIS+RIT GLGIISSN
Sbjct: 57 FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116
 
Query: 181 GKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 360
 GKRWKE RRFSLT LRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCN
Sbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176
 
Query: 361 VICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQVCNNFPLLIDCFPGTHNKLLKN 540
 VICSVVFQKRFDYKD+NFLTLMKRF NFRIL SPWIQVCNNFPLLIDCFPGTHNK+LKN
Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236
 
Query: 541 VALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQEKDNQQSEFTIENLVGTVADLFV 720
 VALT+SYIR+KVKEHQA+LDVNNPRDF+DCFLIKMEQEKDNQ+SEF IENLVGTVADLFV
Sbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296
 
Query: 721 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQ 900
 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAV+HEIQ
Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356
 
Query: 901 RYIDLVPTGVPHAVTTDIKFRNYLIPKGTIIITLLTSVLQDDKEFPNPKIFDPGHFLDEN 1080
 RY DLVPTGVPHAVTTD KFRNYLIPKGT I+ LLTSVL DDKEFPNP IFDPGHFLD+N
Sbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416
 
Query: 1081 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGI 1260
 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV DLKNLNTT+ T+GI
Sbjct: 417 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGI 476
 
Query: 1261 ISLPPSYQICFIPV 1302
 +SLPPSYQICFIPV
Sbjct: 477 VSLPPSYQICFIPV 490
 

>CYP2C75 AY635463.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKFPPGPTPLPVIGNILQ

IDIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

ADRANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

GSPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLKVMEKLNENVKILSSPWIQICNN

FPPFIDYFPGAHNKLLKNIAFLKSYILEKVKEHQESMDMNNPRDFIDCFLMKMEKEKH

NQQSEFTIENLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN

RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFRNYLIPKGTTILISLT

SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEALARMELFLFLT

SVLQNFNLKSLVDPKDLDTTPVVNGFASVPPFYQLCFIPV

>CYP2C19 best hit (N. Abdeltawab) same as Liao’s hit below

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTASPCDPTFILGCAPCNVICSV
IFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ (1)

CNNFPALIDYLPGSHNKVVKNFAYVKS
YVLERIKEHQESLDMDNPRDFIDCFLIKMEEKHNLQSEFTIESLIATVTDMFGAGTETTS
TTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLIP
TNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFKKSD
YFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLY
QLCFIPV

>CYP2C18 M61856

Length = 490

Score = 951 bits (2459), Expect = 0.0

Identities = 468/490 (95%), Positives = 481/490 (98%), Gaps = 3/490 (0%)

Query: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV 60

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTN SKV

Sbjct: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120

YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGE+FSGRGSFPVAEKVNKGLGILFSNGKRW

Sbjct: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKT-ASPCDPTFILGCAPCNVICS 179

KEIRRF LMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 180 VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ-CNNFPALIDYLPGSHNKVVKNFAYV 238

VIFH+RFDYKDQRFLNLMEKFNENLRILSSPWIQ CNNFPALIDYLPGSHNK+ +NFAY+

Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 239 KSYVLERIKEHQESLDMDNPRDFIDCFLIKME-EKHNLQSEFTIESLIATVTDMFGAGTE 297

KSYVLERIKEHQESLDM++ RDFIDCFLIKME EKHN QSEFT+ESLIATVTDMFGAGTE

Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 298 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 357

TTSTTLR+GLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID

Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 358 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 417

L+PTNLPHAVTCDVKF+NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLD+SGNFK

Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 418 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 477

KSDYFMPFSAGKRMC+GEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP

Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 478 PLYQLCFIPV 487

PLYQLCFIPV

Sbjct: 481 PLYQLCFIPV 490

>searched with 2C29 differs from 2C43, 2C74, 2C75 (Liao)

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ

(gap in seq, missing one exon)

EKHNLQSEFTIESLIATVTDMFGAG
TETTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRY
IDLIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGN
FKKSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGR
VPPLYQLCFIPV

>CYP2C9 M61857

Length = 490

Score = 679 bits (1753), Expect = 0.0

Identities = 347/490 (70%), Positives = 386/490 (78%), Gaps = 58/490 (11%)

Query: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

MD V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV

Sbjct: 1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120

YGPVFT+YFGLKPIVVLHGYEAVKEALID GE+FSGRG FP+AE+ N+G GI+FSNGK+W

Sbjct: 61 YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS 180

KEIRRFSLMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFH--------------------------------NRF----DY---------KDQRFL 195

+IFH N F DY K+ F+

Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 196 N--LMEKFNENLRIL--SSPW---------IQVEKHNLQSEFTIESLIATVTDMFGAGTE 242

++EK E+ + ++P ++ EKHN SEFTIESL T D+FGAGTE

Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 243 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 302

TTSTTLR+ LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYID

Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 303 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 362

L+PT+LPHAVTCD+KFRNYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD GNFK

Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 363 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 422

KS YFMPFSAGKR+CVGE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F VP

Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 423 PLYQLCFIPV 432

P YQLCFIPV

Sbjct: 481 PFYQLCFIPV 490

>CYP2B30 AY635461.1

MELSVLLFLALLTGLLLLLVQRHPNAHGRLPPGPCPLPLLGNLL

QMDRRGLLRSFLRFREKYGDVFTVYLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIA

ITDPVFQGYGVVFANGNRWKVLRRFSLTTMRDFGMGKRSVEERIQEEAQCLIEELRKS

KGALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFE

LLSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEK

SNPHSEFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERIYKEIEQVIGP

HRPPALDDRAKMPYTEAVIHEIQRFADLLPMGVPHIVTQQTSFRGYIIPKDTEVFPLL

STALHDPHYFEKPDTFNPDHFLDANGALKKNEAFIPFSLGRRMCLGEGIARNELFLFF

TTILQNFSVASPVAPEDIDLTPQESGVGKIPPTYQIRFLPR

>CYP2B6 search (M.Puljic) partial

GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS

GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS

EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER

Identities = 162/162 (100%), Positives = 162/162 (100%), Gaps = 0/162 (0%)

Query 1 GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 60

GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS

Sbjct 162 GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 221

Query 61 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 120

GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS

Sbjct 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 281

Query 121 EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 162

EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER

Sbjct 282 EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 323

>CYP2F6 AY952296.1

MDSISTAILLLLLALVCLLLTLSSRDKXKLPPGPRPLPLLGNLLLLRSQNMLTSLTQ

LSKEYGSVYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPVFFNFTKGN

GIAFSNGDRWKVLRRFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTE

GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTVIRLINDNFQIMSSPWGE (0)

LYNIFPSLLDWVPGPHQRIFQNFKRLRDLIAHRVHDQQASLDPRSPRDFIDCFLTKMAE

EKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQ

ARVQEEIDLVVGRTRLPTLEDRAAMPYTDAVIHEVQRFADIIPMNLPHRVIRDTAFRXFLIPK

GTDIITLLNTVHYDPSQFLXPQEFNPEHFLDANQSFKKSPAFMPFSA

GRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRSFQLCLCPR

>CYP2D42 (Vasser) also AY635464.1
MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ (0)
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQ (1)
GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQA (1)
GRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLRE (0)
VLNAVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK (0)
AKGNPESSFNEENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR (1)
RVQQEIDNVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIELQGFLIPK (0)
GTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA (1)
GRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGVFAFLVTPSPYELCAVPR*
 
>CYP2D6 NM_000106
Length = 497
Score = 940 bits (2430), Expect = 0.0
Identities = 465/497 (93%), Positives = 476/497 (95%)
 
Query: 1 MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ 60
 M L+ALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDF+NTPYCFDQ
Sbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
 
Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQGVF 120
 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT GEDTADRPPVPI Q+LG GPRSQGVF
Sbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
 
Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQAGRPFRPNSLLDK 180
 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAF + +GRPFRPN LLDK
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
 
Query: 181 AVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLREVLNAVPLLLRIPGLAGKV 240
 AVSNVIASLT GRRFEYDDPRFLRL DL E LKEESGFLREVLNAVP+LL IP LAGKV
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
 
Query: 241 LRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNEENLRIVVA 300
 LR QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN+ENLRIVVA
Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300
 
Query: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDNVIGQVRRPEMGDQARMPYTTAVI 360
 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID+VIGQVRRPEMGDQA MPYTTAVI
Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
 
Query: 361 HEVQRFGDIVPLGVTHMTSRDIELQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHF 420
 HEVQRFGDIVPLG+THMTSRDIE+QGF IPKGTTL TNLSSVLKDEAVWEKPFRFHPEHF
Sbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
 
Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGV 480
 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFT LLQ FSFSVP GQPRPSHHGV
Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
 
Query: 481 FAFLVTPSPYELCAVPR 497
 FAFLV+PSPYELCAVPR
Sbjct: 481 FAFLVSPSPYELCAVPR 497

>CYP2E1 AY635465.1

MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGN

LFQLELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGD

IPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK

TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFQLLSTPWLQLY

NNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKE

KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG

PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPT

LDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLL

LSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS

>CYP2E1 3 aa diffs, partial (F.Zhang)

MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL
AQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNRP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCSPCNVI
ADILFRKHFDYNDEKFLYNNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPN
CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSITLRYGLLILMKYPE
IE

>CYP2E1 J02843
  Length = 493
 
 Score = 576 bits (1484), Expect = e-167
 Identities = 283/322 (87%), Positives = 294/322 (91%), Gaps = 20/322 (6%)
 Frame = -1
 
Query: 906 MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL 727
 MSALGV+VALLVW A LLLVS+WRQVHSSWNLPPGPFPLPIIGNLFQLE KNIPKSFTRL
Sbjct: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
 
Query: 726 AQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNRP 547
 AQRFGPVFTLYVGS+R+VV+HGYKAV+E LLD+KDEFSGRGD+PAFHAHRDRGIIFNN P
Sbjct: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
 
Query: 546 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCSPCNVI 367
 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGC+PCNVI
Sbjct: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180
 
Query: 366 ADILFRKHFDYNDEKF--------------------LYNNFPSLLHYLPGSHRKVMKNVA 247
 ADILFRKHFDYNDEKF LYNNFPS LHYLPGSHRKV+KNVA
Sbjct: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240
 
Query: 246 EIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 67
 E+KEYVSERVKEH QSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
Sbjct: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300
 
Query: 66 TETTSITLRYGLLILMKYPEIE 1
 TETTS TLRYGLLILMKYPEIE
Sbjct: 301 TETTSTTLRYGLLILMKYPEIE 322

>CYP2G2P best hit (Li Chen) Note this does not look like a pseudogene
see red regions below.
exon 2 = trace archive file 456149111
MELGGAVTIFLALCLSCLLVLIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK (0)
LKEKYGPLFTVYMGLWPVVVLCGHEAVKEALIDQADEFSGRGKLASIEQNFQGH (1)
GVALANGERWRILRRFSLTILRDFGMGKRSIEERILEEASYLLEEFRKTK (1)
GAPIDPTFLLSRTVSNVISSVVFGSRFDYEDKQFLNLLRLINESFIEMSTPWAQ (0)
LYDMYSGIMQYLPGRHNRVYYLIEQLKDFIASRVKINEASFDSQNPRDFIDCFLIKMHQ (0)
DKNNPRTEFNLKNLVLTALNLFFAGTETVSSTLRYGFLLLMKHPEVE (1)
ARIHEEINQVIGPHRLPSVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNVIRDTQFRGYLLPK (0)
GTDVFPLLGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNEAFVPFSS (1)
GKRICLGEAMARMELFLYFTSILQNFSPRSLVPPADIDITPKLSGFGNIPPTYELCLVAR

Score = 933 bits (2411), Expect = 0.0

Identities = 463/496 (93%), Positives = 476/496 (95%), Gaps = 2/496 (0%)

Query: 1 MELGGAVTIFLALCLSCLLVLIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

ME+GGAVTIFLALCLSCLL+LIAWK MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK

Sbjct: 1 MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

Query: 61 LKEKYGPLFTVYMGLWPVVVLCGHEAVKEALIDQADEFSGRGKLASIEQNFQGHGVALAN 120

L+EKY P+FTVYMG PVVVLCGHEAVKEAL+DQADEFSGRG+LASI+QNFQGHGVALAN

Sbjct: 61 LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGHGVALAN 120

Query: 121 GERWRILRRFSLTILRDFGMGKRSIEERILEEASYLLEEFRKTKGAPIDPTFLLSRTVSN 180

GERWRIL RF LTILRDFGMGKRSIEERI EEASYLLEEFRKTKGAPIDP FLLSRTVSN

Sbjct: 121 GERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTKGAPIDPIFLLSRTVSN 180

Query: 181 VISSVVFGSRFDYEDKQFLNLLRLINESFIEMSTPWAQLYDMYSGIMQYLPGRHNRVYYL 240

VISSVVF SRFDYEDKQFLNLLRLINESFIEMSTPWAQLYDMYSGIMQYLPGRHN +YYL

Sbjct: 181 VISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQLYDMYSGIMQYLPGRHNLIYYL 240

Query: 241 IEQLKDFIASRVKINEASFDSQNPRDFIDCFLIKMHQDKNNPRTEFNLKNLVLTALNLFF 300

+E+LKDFIASRVKINEASFD QNPRDFIDCFLIKMHQDKNNPRTEFNLKNLVLT LNLFF

Sbjct: 241 VEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKNNPRTEFNLKNLVLTTLNLFF 300

Query: 301 AGTETVSSTLRYGFLLLMKHPEVEARIHEEINQVIGPHRLPSVDDRVKMPYTDAVIHEIQ 360

AGTETVSSTLRYGFLLLMKHPEVEA+IHEEINQVIGPHRLP VDDRVKMPYTDAVIHEIQ

Sbjct: 301 AGTETVSSTLRYGFLLLMKHPEVEAKIHEEINQVIGPHRLPRVDDRVKMPYTDAVIHEIQ 360

Query: 361 RLVDIVPMGVPHNVIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYPEAFYPQHFLDEQ 420

RLVDIVPMGVPHN+IRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYP+AFYPQHFLDEQ

Sbjct: 361 RLVDIVPMGVPHNLIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQ 420

Query: 421 GRFKKNEAFVPFSS--GKRICLGEAMARMELFLYFTSILQNFSPRSLVPPADIDITPKLS 478

GRFKKNEAFVPFSS GKRICLGEAM RMELFLYFTS LQNFS SLVPP DIDITPKLS

Sbjct: 421 GRFKKNEAFVPFSSGRGKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKLS 480

Query: 479 GFGNIPPTYELCLVAR 494

GFGNIPPTYELCLVAR

Sbjct: 481 GFGNIPPTYELCLVAR 496

>CYP2J2 best hit (Z. Zhang) partial

GLIMSSGQIWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI
NNAVSNIICSITFGERFDYQDSQFQELLKLLDEVTYLEASKTCQLYNIFPWLMKFLPGPH
QTLFSNWEKLKLFVSHMIEKHRKDWNPAETRDFIDAYLKEMSKHTGNSTSSFHEENLICS
TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNA
VIHEVQRMGNIVPLNVPREVTVDTTLAGYHLPKRACLGEQLARTELFIFFTSLVQKFTFR
PPNNEKLSLKFRMGITISPVSHHLC

>CYP2J2 NM_000775 chr 1
 Length = 497
 
 Score = 618 bits (1594), Expect = e-180
 Identities = 311/373 (83%), Positives = 319/373 (85%), Gaps = 48/373 (12%)
 
Query: 1 GLIMSSGQIWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI 60
 GLIMSSGQ WKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI
Sbjct: 125 GLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI 184
 
Query: 61 NNAVSNIICSITFGERFDYQDSQFQELLKLLDEVTYLEASKTCQLYNIFPWLMKFLPGPH 120
 NNAVSNIICSITFGERF+YQDS FQ+LLKLLDEVTYLEASKTCQLYN+FPW+MKFLPGPH
Sbjct: 185 NNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPH 244
 
Query: 121 QTLFSNWEKLKLFVSHMIEKHRKDWNPAETRDFIDAYLKEMSKHTGNSTSSFHEENLICS 180
 QTLFSNW+KLKLFVSHMI+KHRKDWNPAETRDFIDAYLKEMSKHTGN TSSFHEENLICS
Sbjct: 245 QTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICS 304
 
Query: 181 TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNA 240
  TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQ EIDRVIGQGQQPSTAARESMPYTNA
Sbjct: 305 TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQVEIDRVIGQGQQPSTAARESMPYTNA 364
 
Query: 241 VIHEVQRMGNIVPLNVPREVTVDTTLAGYHLP---------------------------- 272
 VIHEVQRMGNI+P NVPREVTVDTTLAGYHLP 
Sbjct: 365 VIHEVQRMGNIIPQNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPD 424
 
Query: 273 --------------------KRACLGEQLARTELFIFFTSLVQKFTFRPPNNEKLSLKFR 312
 KRACLGEQLARTELFIFFTSL+QKFTFRPPNNEKLSLKFR
Sbjct: 425 HFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFR 484
 
Query: 313 MGITISPVSHHLC 325
 MGITISPVSH LC
Sbjct: 485 MGITISPVSHRLC 497

>CYP2R1 (G.Zhu) partial

IFSLDLGGISTVVLNGYDVVKECLVHQSGIFADRPCLPLFMKMTKMGGLLNSRYGQGWVE
HRRLAVNSFRYFGYGQKSFESKILEETKFFTDAIETYKGRPFDFKQLITSAVSNITNLII
FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNASVVYD
FLSRLIEKASVNRKPQLPQHFVDAYFDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT
TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKFKMPYTEAVLHEVLRFCNIV
PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK
EALVPFSLGRRHCLGEQLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL
ICAERR

Alignment of the two sequences, 97% identical

Query: 1 IFSLDLGGISTVVLNGYDVVKECLVHQSGIFADRPCLPLFMKMTKMGGLLNSRYGQGWVE 60
 IFSLDLGGISTVVLNGYDVVKECLVHQS IFADRPCLPLFMKMTKMGGLLNSRYG+GWV+
Sbjct: 76 IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135
 
Query: 61 HRRLAVNSFRYFGYGQKSFESKILEETKFFTDAIETYKGRPFDFKQLITSAVSNITNLII 120
 HRRLAVNSFRYFGYGQKSFESKILEETKFF DAIETYKGRPFDFKQLIT+AVSNITNLII
Sbjct: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195
 
Query: 121 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNASVVYD 180
 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNA+VVYD
Sbjct: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255
 
Query: 181 FLSRLIEKASVNRKPQLPQHFVDAYFDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 240
 FLSRLIEKASVNRKPQLPQHFVDAY DEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT
Sbjct: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315
 
Query: 241 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKFKMPYTEAVLHEVLRFCNIV 300
 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDK KMPYTEAVLHEVLRFCNIV
Sbjct: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375
 
Query: 301 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 360
 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK
Sbjct: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435
 
Query: 361 EALVPFSLGRRHCLGEQLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL 420
 EALVPFSLGRRHCLGE LARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL
Sbjct: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL 495
 
Query: 421 ICAERR 426
 ICAERR
Sbjct: 496 ICAERR 501

>CYP2S1 exons 2,3 from CO649282.1, gene fragmented on multiple scaffolds

MEATGTWALLLALALLLLLTLALSGTRARGQLPPGPTPLPLLGNLLQLRPGALYSGLMR (0)

LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH (1)

GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE (1)

GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAMVRAAGGTLLGVSSRGGQ (0)

TYEMCSWFLWPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ (0)

EEQNPDTEFTNKNMLMTVIYLLFAGTMTVSATVGYTLLLLMKYPHVQ (1)

KRVREELTQELGSGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ (0)

GTEVFPLLGSILHDPSIFKHPEEFNPDHFLDADGRFRKHEAFLPFSL (1)

GKRVCLGEGLAKAELFLFFTTILQAFSLESPCPLDSLSLKPTISGLFNIPPAFQLQVRPTDLHSTTQTT*

>CYP2S1 AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13

Length = 504

Score = 970 bits (2508), Expect = 0.0

Identities = 485/503 (96%), Positives = 494/503 (98%)

Query: 1 MEATGTWALLLALALLLLLTLALSGTRARGQLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

MEATGTWALLLALALLLLLTLALSGTRARG LPPGPTPLPLLGNLLQLRPGALYSGLMRL

Sbjct: 1 MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

Query: 61 SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN

Sbjct: 61 SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN

Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

Query: 181 VVCSLLFGLRFSYEDKEFQAMVRAAGGTLLGVSSRGGQTYEMCSWFLWPLPGPHKQLLHH 240

VVCSLLFGLRFSYEDKEFQA+VRAAGGTLLGVSS+GGQTYEM SWFL PLPGPHKQLLHH

Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

Query: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPDTEFTNKNMLMTVIYLL 300

VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNP TEFTNKNMLMTVIYLL

Sbjct: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

Query: 301 FAGTMTVSATVGYTLLLLMKYPHVQKRVREELTQELGSGQAPSLGDRTRLPYTDAVLHEA 360

FAGTMTVS TVGYTLLLLMKYPHVQK VREEL +ELG+GQAPSLGDRTRLPYTDAVLHEA

Sbjct: 301 FAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEA 360

Query: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPSIFKHPEEFNPDHFLDA 420

QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILH+P+IFKHPEEFNPD FLDA

Sbjct: 361 QRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHEPNIFKHPEEFNPDRFLDA 420

Query: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPLDSLSLKPTISG 480

DGRFRKHEAFLPFSLGKRVCLGEGLAKAE+FLFFTTILQAFSLESPCP D+LSLKPT+SG

Sbjct: 421 DGRFRKHEAFLPFSLGKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPDTLSLKPTVSG 480

Query: 481 LFNIPPAFQLQVRPTDLHSTTQT 503

LFNIPPAFQLQVRPTDLHSTTQT

Sbjct: 481 LFNIPPAFQLQVRPTDLHSTTQT 503

>CYP2T2P ortholog, SCAFFOLD100362 (+) 38209-41795

frameshift in exon 4 after VIC, numerous other defects

MIAGIAALLLWLLVLALARWG*GGCRARMRGSLPPRPRPLPLLGNLQLQSGGTDHALHS (?)

LSGRWGPVFTAQLGPRPAVVLCGYAALRDALVLQADAFSGRGSMAVFERFTRGH (1)

GIFLSNGPRWWTLRNFAVGALKELGLGTRTIQAHVLEEAACLLDEMQATI (1)

GAPFDPMRLLDNAVSNVICX

LVFGNRYGYGDPEFLRLLNLFSDNFRIMSSRWGE (0)

(?) SLMDWLPGRHRRIFRNF

SELWVFISEQIQQHWQMRQPAEPRDFINCLTRWVRRGSQ

QDPESHFQEETSVMMTHLFFGGTETSTTLCYGLLVLLKYPEVA (1)

AKVQELDPVVGWRCAPSPDDHQRLPYTNAVLLQIQRFISVVPLGLPRX

TLNTHLHSHCLPK (1)

GTFVIPLLVTAHXDRTQFKDPDCFNATNFLDKGKSQGNDPFMPFAS (1)

(?) GKQMCLGAGLAHLEIFLFLTATLPRFRLLPVVNPGTINLT

QFTGLGSVPPAFQLQLVAC

>CYP2T2P AC008537

Length = 457

Score = 2103 (740.3 bits), Expect = 7.1e-222, P = 7.1e-222

Identities = 413/482 (85%), Positives = 427/482 (88%)

Query: 1 MIAGIAALLLWLLVLALARWG*GGCRARMRGSLPPRPRPLPLLGNLQLQSGGTDHALHSL 60

M AGIAALLLWLLVLA A WG*GGCRA+MRGSLPPRPRPLPLLGNLQLQSGG D ALHSL

Sbjct: 1 MXAGIAALLLWLLVLAPAWWG*GGCRAQMRGSLPPRPRPLPLLGNLQLQSGGLDRALHSL 60

Query: 61 SGRWGPVFTAQLGPRPAVVLCGYAALRDALVLQADAFSGRGSMAVFERFTRGHGIFLSNG 120

SGRWG VFT +LGPRPAV LCGYAALRDALVLQADA SGRGSMAVFERFTRG+GI SN

Sbjct: 61 SGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFTRGNGILFSNR 120

Query: 121 PRWWTLRNFAVGALKELGLGTRTIQAHVLEEAACLLDEMQATIGAPFDPMRLLDNAVSNV 180

P WWTLRNFA+GALK+ GLGTRT++A VLEEAACLLDE QATIGAPFDP+RLLDNAVSNV

Sbjct: 121 PCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATIGAPFDPVRLLDNAVSNV 180

Query: 181 ICXLVFGNRYGYGDPEFLRLLNLFSDNFRIMSSRWGESLMDWLPGRHRRIFRNFSELWVF 240

IC LVFGNRY YGDPEFLRLLNLFSDNF I+SSRWGESLMDWLPG H RIFRNFSEL V

Sbjct: 181 ICSLVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRIFRNFSELRV- 239

Query: 241 ISEQIQQHWQMRQPAEPRDFINCLTRWVRRGSQQDPESHFQEETSVMMTHLFFGGTET-S 299

ISEQIQ+HWQMRQPAEPRDFI+CLTRWVR G QQDPESHFQE TSVM TH FFG TET S

Sbjct: 240 ISEQIQRHWQMRQPAEPRDFIDCLTRWVRHG-QQDPESHFQE*TSVMTTHFFFGVTETTS 298

Query: 300 TTLCYGLLVLLKYPEVAAKVQELDPVVGWRCAPSPDDHQRLPYTNAVLLQIQRFISVVPL 359

TTLCYGLL+LLKY EVAAKVQELDPVVGWR APS D LPY NAVLL+IQ FISVVPL

Sbjct: 299 TTLCYGLLILLKYLEVAAKVQELDPVVGWRPAPSLDYRVCLPYANAVLLEIQCFISVVPL 358

Query: 360 GLPRX-TLNTHLHSHCLPKGTFVIPLLVTAHXDRTQFKDPDCFNATNFLDKGKSQGNDPF 418

GLPR TL+THLHSHCLPKGTFVIPLLVTAH D TQFKDPDCFN TNFLDKGK QGND F

Sbjct: 359 GLPRTLTLDTHLHSHCLPKGTFVIPLLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAF 418

Query: 419 MPFASGKQMCLGAGLAHLEIFLFLTATLPRFRLLPVVNPGTINLTQFTGLGSVPPAFQLQ 478

MPFA KQMCLG GLAH IFLFLTATL RF LLPVV PGTINLTQ TGLGSVPP FQLQ

Sbjct: 419 MPFAPAKQMCLGTGLAHSGIFLFLTATLQRFCLLPVVRPGTINLTQCTGLGSVPPDFQLQ 478

Query: 479 LVAC 482

VAC

Sbjct: 479 PVAC 482

>CYP2U1 (li Chen) note gc boundary between exons 7,8
MSSPGPPQPPAEDPPWPARLLRAPLGLLRMDPSGDALLLCGLVAVLGWSWLRRRRARGIP PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVVGPQVLLAHLARVYGSIFSF FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEK (1)
GVVFAHYGPIWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI
ISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLMVNICPWLYYLPFGP
FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLF
YIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ (1)
EKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSGNT (1)
VLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGI (1)

GKRVCMGEQLAKMELFLMFVSLMQSFAFALPEKSKKPLLTGRFGLTLAPHPFNITISRR*

Score = 1098 bits (2841), Expect = 0.0

Identities = 535/544 (98%), Positives = 540/544 (99%)

Query: 1 MSSPGPPQPPAEDPPWPARLLRAPLGLLRMDPSGDALLLCGLVAVLGWSWLRRRRARGIP 60

MSSPGP QPPAEDPPWPARLLRAPLGLLR+DPSG ALLLCGLVA+LGWSWLRRRRARGIP

Sbjct: 1 MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 60

Query: 61 PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVVGPQVLLAHLARVYGSIFSF 120

PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSV+GPQVLLAHLARVYGSIFSF

Sbjct: 61 PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPIWRQQRKF 180

FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGP+WRQQRKF

Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKF 180

Query: 181 SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR 240

SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR

Sbjct: 181 SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR 240

Query: 241 FDYTNSEFKKMLGFMSRGLEICLNSQVLMVNICPWLYYLPFGPFKELRQIEKDITSFLKK 300

FDYTNSEFKKMLGFMSRGLEICLNSQVL+VNICPWLYYLPFGPFKELRQIEKDITSFLKK

Sbjct: 241 FDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKK 300

Query: 301 IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS 360

IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS

Sbjct: 301 IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS 360

Query: 361 LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA 420

LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA

Sbjct: 361 LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA 420

Query: 421 IPHMTSGNTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480

IPHMTS NTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF

Sbjct: 421 IPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480

Query: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEKSKKPLLTGRFGLTLAPHPFNIT 540

IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPE SKKPLLTGRFGLTLAPHPFNIT

Sbjct: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNIT 540

Query: 541 ISRR 544

ISRR

Sbjct: 541 ISRR 544

>CYP2W1 Macaca mulatta rhesus monkey (Mahrous)

LSERYGPVFTVHLGCQKTVVLTGFEVVKEALAGPGQELADRPPIAIFQLIQRGG (1)

GIFFSSGARWRAARQFTVRALHSLGVGRKPVADKILQELKCLLGQLDGYR (1)

GQPFPLALLGWAPSNITFTLLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQ (0)

LFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHMRPGDPVCSYVDALIQQGQ (0)

GDDPEGLFAEDNAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQ (1)

GRVQEELDRVLRRGRPPQPEDQQVLPYTSAVLHEVQRFITLLPHVPRCTATDMQLGGFLLPK (0)

GTPVIPLLTSVLLDETQWQTPDQFNPGHFLDADGHFVKQEAFLPFSA (1)

GRRVCVGERLARTELFLLFAGLLQKYYLLPPPGVSPASLDTTPAQAFTMRPRAQALCAVPRP

Missing part =

ggggatgaccccgagggctxgtttgctgaggacaacgcagtggcx

G D D P E G L F A E D N A V A

>CYP2W1 AC073957.7 chromosome 7 clone RP11-449P15 40% to 2F1

Length = 490

Score = 785 bits (2027), Expect = 0.0

Identities = 395/432 (91%), Positives = 403/432 (93%), Gaps = 14/432 (3%)

Query: 1 LSERYGPVFTVHLGCQKTVVLTGFEVVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSS 60

LSERYGPVFTVHLG QKTVVLTGFE VKEALAGPGQELADRPPIAIFQLIQRGGGIFFSS

Sbjct: 59 LSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSS 118

Query: 61 GARWRAARQFTVRALHSLGVGRKPVADKILQELKCLLGQLDGYRGQPFPLALLGWAPSNI 120

GARWRAARQFTVRALHSLGVGR+PVADKILQELKCL GQLDGYRG+PFPLALLGWAPSNI

Sbjct: 119 GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNI 178

Query: 121 TFTLLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIE 180

TF LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIE

Sbjct: 179 TFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIE 238

Query: 181 EVRAILRTLLEARRPHMRPGDPVCSYVDALIQQGQ--------------VCTLDMVMAGT 226

EVRAILRTLLEARRPH+ PGDPVCSYVDALIQQGQ CTLDMVMAGT

Sbjct: 239 EVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGT 298

Query: 227 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLRRGRPPQPEDQQVLPYTSAVLHEVQRFI 286

ETTSATLQWAALLMGRHPDVQGRVQEELDRVL GR P+ EDQQ LPYTSAVLHEVQRFI

Sbjct: 299 ETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFI 358

Query: 287 TLLPHVPRCTATDMQLGGFLLPKGTPVIPLLTSVLLDETQWQTPDQFNPGHFLDADGHFV 346

TLLPHVPRCTA D QLGGFLLPKGTPVIPLLTSVLLDETQWQTP QFNPGHFLDA+GHFV

Sbjct: 359 TLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFV 418

Query: 347 KQEAFLPFSAGRRVCVGERLARTELFLLFAGLLQKYYLLPPPGVSPASLDTTPAQAFTMR 406

K+EAFLPFSAGRRVCVGERLARTELFLLFAGLLQ+Y LLPPPGVSPASLDTTPA+AFTMR

Sbjct: 419 KREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMR 478

Query: 407 PRAQALCAVPRP 418

PRAQALCAVPRP

Sbjct: 479 PRAQALCAVPRP 490

>CYP2AB1P SCAFFOLD46808:34-204, SCAFFOLD101629:758-8003 (no ESTs found)

missing exons 2,3,7 exon 2 = Trace archive 650631246, 555635842

frameshift after THG and gc boundary in exon 2 (gc also in human)

exon 3 = 497888434

MLSLLSGLALLAISFLLLKLGTFCWDRNRLPPGPFPFPILGNLWQLRFQLHPETLLQ (0)

LAQTHG

VCLFTVWVSPIPIVVLSGFRAVKEALVSNSEQFSGRPLTSLFQDLFGEQ (1)

GIVCSRRHMWWQQRRFCLVTLQGLGLGKLALEVQLQKQAAELVEAFRQEL (1)

SRSFDPQVSIVRSTVRVIGALVFGHHFLSEDPIFQELTQAIDFGLALVRTVWHW (0)

LHDVFPRALCHLPGSHREIFRYQGVVRSFTRREITGRKLKALEALKDFINCSLAQISK (0)

AMDEPVSTFHEENLVQVVIDLFLGGTNTTATTQRWALVYMIQHGAVQ (1?)

GTIILPLCRGSVLYDPECWETPPQFNPGHFLDKDGNFVANEAFLPFSA (1)

GHCVCPGDQLARMELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGTLQPQPQEICAVPR

>CYP2AB1 comparing only the known sequence, leaving out missing exon 7.

Length = 423, human has lost the KYG motif (THG in rhesus), lost heme Cys

Score = 1794 (631.5 bits), Expect = 3.6e-189, P = 3.6e-189

Identities = 353/428 (82%), Positives = 376/428 (87%)

Query: 1 MLSLLSGLALLAISFLLLKLGTFCWDRNRLPPGPFPFPILGNLWQLRFQLHPETLLQLAQ 60

MLSLLSGLALLAISFLLLKLGTFCWDR+ LPPGP PFPILGNLWQL FQLHPETLLQLAQ

Sbjct: 1 MLSLLSGLALLAISFLLLKLGTFCWDRSCLPPGPLPFPILGNLWQLCFQLHPETLLQLAQ 60

Query: 61 THGVCLFTVWVSPIPIVVLSGFRAVKEALVSNSEQFSGRPLTSLFQDLFGEQGIVCSRRH 120

+ +FTVWV PIP+ VLSGF+ VKEALVSNSEQFSGR LT LFQDLFGE+GI+CS H

Sbjct: 61 S----VFTVWVGPIPVAVLSGFQVVKEALVSNSEQFSGRSLTPLFQDLFGERGIICSSGH 116

Query: 121 MWWQQRRFCLVTLQGLGLGKLALEVQLQKQAAELVEAFRQELSRSFDPQVSIVRSTVRVI 180

W Q+RRFCLV + GLGLGKLALEVQLQK+AAEL EAFRQE R FDPQVSIVRSTVRVI

Sbjct: 117 TWRQKRRFCLVMI*GLGLGKLALEVQLQKEAAELAEAFRQEQGRPFDPQVSIVRSTVRVI 176

Query: 181 GALVFGHHFLSEDPIFQELTQAIDFGLALVRTVWHWLHDVFPRALCHLPGSHREIFRYQG 240

GALVFGHHFL EDPIFQELTQAIDFGLA V TVW L+DVFP ALCHLPG H+EIFRYQ

Sbjct: 177 GALVFGHHFLLEDPIFQELTQAIDFGLAFVSTVWRRLYDVFPWALCHLPGPHQEIFRYQE 236

Query: 241 VVRSFTRREITGRKLKALEALKDFINCSLAQISKAMDEPVSTFHEENLVQVVIDLFLGGT 300

VV S +EIT KL+A EA +DFI+C LAQISKAMD+PVSTF++ENLV VVIDLFLGGT

Sbjct: 237 VVLSLIHQEITRHKLRAPEAPRDFISCYLAQISKAMDDPVSTFNQENLV*VVIDLFLGGT 296

Query: 301 NTTATTQRWALVYMIQHGAVQGTIILPLCRGSVLYDPECWETPPQFNPGHFLDKDGNFVA 360

+TTATT WAL++MIQHGAVQGTIILP SVLYDPECWETP QFNPGHF DKDGNFVA

Sbjct: 297 DTTATTLCWALIHMIQHGAVQGTIILPNL-ASVLYDPECWETPRQFNPGHFSDKDGNFVA 355

Query: 361 NEAFLPFSAGHCVCPGDQLARMELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGTLQPQP 420

NEAFLPFSAGH V P DQLA+MELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGT QPQP

Sbjct: 356 NEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGTWQPQP 415

Query: 421 QEICAVPR 428

QEICAVPR

Sbjct: 416 QEICAVPR 423

>CYP2AC1P SCAFFOLD 55146 (+) 91919 103589

note: upstream neighbor is the rhag gene that flanks the Xenopus 31 gene cluster. This large gene cluster may have originated from the CYP2AC1 gene. This gene is on human chromosome 6. In humans rhag is about 22kb upstream of CYP2AC1.

Exon 1 = SCAFFOLD 70822:43519-43602

Exon 3 = SCAFFOLD 103481:817-966

1 MSEFDASAILPIRVLILIFILSIKKFMTEASKQLSPPGPRPLLVIGNLYFLNLKRPYQTMLE (0)

3 GIAFFHGETWKTMRWFSLTTLQNFGMDEWIIEDTIIEECQNLIQNSEFHR

4 GKSFEMKTIMNASVVNIIVLVLPGKWFDYQDSQFLRLLALIGENVKLIGGLRIAVN (1)

5 SFQYVSFWGVLLKSHKTVFRNRDELFSFIRMIFLDHCHKLDKNDPRSFTDAFLVTQQE (0)

6 ENDTFADHFSDENLMALVNNLFTTGTETTASTLPWGILLVICLRSRV (1)

7 KKVHNEVTKVARSAQP*LAHQTQMPHTDAVSHEVQRFANILPTSLPHATPTNIFKNYYIPK (0)

8 ATEVIILLASVRRDQAQWEKPDTFNPEHFLTSKGKFIKREAFLPFTV (1)

9 GRRMCAGESSAR MELFLFFTSLLQ KFTFQPPLGVSHLDLDLSLDIGFTT*

>CYP3A64 AY582531.1

MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL

PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF

TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL

RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP

FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI

DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE

IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV

VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM

NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA

>CYP3A43 ortholog? partial assembly (Aggarwal) 72% to 3A64
MDLIPNFAMETWVLVATSLVLL (2)
YIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLR (0)
GLWKFDRECNEKYGEMWG (2)
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNRM (0)
PLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKE (0)
MVPIISQCGDMLVRSLRREAENSKPTNLKE
 
>CYP3A43 AC011904 one exon per line
 Length = 504
 
 Score = 348 bits (893), Expect = 5e-99
 Identities = 168/174 (96%), Positives = 171/174 (98%)
 
Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWKF 60
 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLW F
Sbjct: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60
 
Query: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNRMPLGPMGFMKSALSF 120
 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN+MPLGPMGF+KSALSF
Sbjct: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120
 
Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRREAENSKPTNLKE 174
 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLR+EAENSK NLKE
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKE 174
 
>CYP4A11 match (ramy.Naguib) partial seq. Missing exon 1 (added later)
MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLFGHKQE (0)
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS (1)
DPKSQDPYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML (0)
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK (1)
GITVMLSIYGLHHNPKVWPNPE (0)
VFDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
 
The alignment of the two proteins:
 

Score = 1010 bits (2612), Expect = 0.0

Identities = 491/519 (94%), Positives = 499/519 (96%)

Query: 1 MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLF 60

MSVSVLSPSRLLG VSGILQ ASLLILLLLLIKA QLYLHRQWLLKA QQFPC PSHWLF

Sbjct: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60

Query: 61 GHKQEFQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRSDPKSQDPY 120

GH QE QQDQELQRI+KWVE FPSACP WLWGGK RVQL+DPDYMKVILGRSDPKS Y

Sbjct: 61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120

Query: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVMLDKWEKLLGQD 180

RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILK YV LMADSVRVMLDKWE+LLGQD

Sbjct: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180

Query: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRDSQSYIQAISDLNNLVFSRVRNVFHQND 240

SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR+SQSYIQAISDLNNLVFSRVRN FHQND

Sbjct: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240

Query: 241 TIYSLTSTGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAKM 300

TIYSLTS GRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEK+KRK+HLDFLDILLLAKM

Sbjct: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300

Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360

ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGAS

Sbjct: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360

Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHH 420

ITWNHLDQMPYTTMCIKEALRLYPPVPGI RELSTPVTFPDGRSLPKGI V+LSIYGLHH

Sbjct: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420

Query: 421 NPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480

NPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL

Sbjct: 421 NPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480

Query: 481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 519

LPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL

Sbjct: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519

>CYP4A22 search (Puljic) same seq as the 4A11 hit above

MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLF

GHKQEFQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRSGYGLLLLN

GQTWFQHRRMLTPAFHYDILKAYVALMADSVRVMLDKWEKLLGQDSPLEVFQHVSLMTLD

TIMKCAFSHQGSIQVDRDSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRA

CQLAHQHTETK*SN*GRLNYRRRGSWRRSRGRSTWISWTSSSWPKWRMGASCQTRTSVPK

WTHSCSRATTPQPVGSPGFCMLWPHTPSIRRGAGKRSMASWVMEPPSPGENHLDQMPYTT

MCIKEALRLYPPVPGISRELSTPVTFPDGRSLPKGITVMLSIYGLHHNPKVWPNPEVFDP

SRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMAR

LVLKSKNGIHLRLRRLPNPCEDKDQL

>CYP4B1

MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE (0)

IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG (1)

DPKAPDVYDFFLQWI (1)

GRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML (0)

DKWEEKAQEGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHR (2)

DSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLTPHGRRFLRACQVAHDHT (1)

DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR (0)

DEDDSKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQW (2)

DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA (1)

GSLISMHIYALHRNSAVWPDPE (0)

VFDPLRFSTENASKRHPFAFMPFSAGPR (2)

NCIGQQFAMSEMKVVTAMCLLHFEFSLDPSRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK

>CYP4B1 NM_000779

Length = 511

Score = 1020 bits (2638), Expect = 0.0

Identities = 490/511 (95%), Positives = 495/511 (96%)

Query: 1 MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE 60

MVPSFLSL S LGLWASGLILVLGFLKLI LLLRR+ LAKAM FPGPPTHWLFGHALE

Sbjct: 1 MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRRTLAKAMDKFPGPPTHWLFGHALE 60

Query: 61 IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

IQ+TGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ

Sbjct: 61 IQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQ 120

Query: 121 WIGRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVMLDKWEEKAQEGKSFDI 180

WIGRGLLVLEGPKW QHRKLLTPGFHYDVLKPYVA+F ESTR+MLDKWEEKA+EGKSFDI

Sbjct: 121 WIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDI 180

Query: 181 FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLT 240

FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSF YHNDFIYWLT

Sbjct: 181 FCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLT 240

Query: 241 PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDSKL 300

PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDD KL

Sbjct: 241 PHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKL 300

Query: 301 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQWDDL 360

SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQD FQWDDL

Sbjct: 301 SDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDL 360

Query: 361 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP 420

GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP

Sbjct: 361 GKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWP 420

Query: 421 DPEVFDPLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLHFEFSLDP 480

DPEVFD LRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLL FEFSLDP

Sbjct: 421 DPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDP 480

Query: 481 SRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK 511

SRLPIKM QLVLRSKNG HLHLKPLGPGSGK

Sbjct: 481 SRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK 511

>CYP4V2 (S.Sarva)

MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV 
GHALLMKRDGR (1)
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE (0)
VILTSSKQIDKSSMYKFLEPWLGLGLLTS (2)
TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHVNQEAFNCFVYITLCALDIIC (1)
ETAMGKNIGAQSNDDSEYVRAVYR (2)
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHAFTNN (0)
VIAERANEMNVDEDCRGDGRDSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE (0)
GHDTTAAAMNWSLYLLGSNPEVQKKVDHELDDVF (1)
GRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV (1)
AGYRVLKGTEAV
IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCI (1)
GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 1551

Score = 1040 bits (2688), Expect = 0.0

Identities = 508/524 (96%), Positives = 517/524 (98%), Gaps = 1/524 (0%)

Frame = +2

Query 1 MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV 60

MAG+WLGLVWQKLLLWGAASA+SLAGASLVLSLLQRVASY RKWQQMRPIPTVARAYPLV

Sbjct 305 MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 484

Query 61 GHALLMKRDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK 120

GHALLMK DGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK

Sbjct 485 GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK 664

Query 121 SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 180

SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH

Sbjct 665 SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 844

Query 181 VNQEAFNCFVYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW 240

+NQEAFNCF YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW

Sbjct 845 INQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW 1024

Query 241 LDLWYLMFKEGWEHKKSLKILHAFTNNVIAERANEMNVDEDCRGDGRDSAPSKNKRRAFL 300

LDLWYLMFKEGWEHKKSLKILH FTN+VIAERANEMN +EDCRGDGR SAPSKNKRRAFL

Sbjct 1025 LDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL 1204

Query 301 DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAMNWSLYLLGSNPEVQKKVDHELD 360

DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAA+NWSLYLLGSNPEVQKKVDHELD

Sbjct 1205 DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD 1384

Query 361 DVFGRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV 419

DVFG++DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV

Sbjct 1385 DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV 1564

Query 420 IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI 479

IIPYALHRDPRYFPNPEEF+PERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI

Sbjct 1565 IIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI 1744

Query 480 LSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 523

LSCILRHFWIESNQKREELGLEGQLILRP+NGIWIKLKRRNADE

Sbjct 1745 LSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADE 1876

>CYP4X1 (Vasser) missing exon 1

FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTFLSRT (1)

DPKSQYLQKFLPPLI (1)

GKGLLALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKTML (0)

DKWEKICSTQNTSVEVYEHINLMSLDIIMKCAFSKETNCQTN (2)

STHDPYVKAIFELGKIIFHRLYSFLYHSDIIFKLSPQGYRFQKLSRVLNQYT (1)

DAIIQERKKSLQAGEKQDNTQKRKYQDFLDIVLSAK (0)

DENGSSFSDTDVHSEVSMFLLGGHDSLAASISWILYCLALNPEHQERCREEVRGILGDGCSITW (2)

DQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA*

>CYP4X1 R56515, R53456, AA652746, AC026935

 Length = 506
 

Score = 664 bits (1714), Expect = 0.0

Identities = 323/343 (94%), Positives = 327/343 (95%)

Query: 1 FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTFLSRTDPKSQYLQKFLPP 60

FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFF IYDPDYAKT LSRTDPKSQYLQKF PP

Sbjct: 60 FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP 119

Query: 61 LIGKGLLALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKTMLDKWEKICSTQNTSVE 120

L+GKGL ALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVK MLDKWEKICSTQ+TSVE

Sbjct: 120 LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE 179

Query: 121 VYEHINLMSLDIIMKCAFSKETNCQTNSTHDPYVKAIFELGKIIFHRLYSFLYHSDIIFK 180

VYEHIN MSLDIIMKCAFSKETNCQTNSTHDPY KAIFEL KIIFHRLYS LYHSDIIFK

Sbjct: 180 VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK 239

Query: 181 LSPQGYRFQKLSRVLNQYTDAIIQERKKSLQAGEKQDNTQKRKYQDFLDIVLSAKDENGS 240

LSPQGYRFQKLSRVLNQYTD IIQERKKSLQAG KQDNT KRKYQDFLDIVLSAKDE+GS

Sbjct: 240 LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGS 299

Query: 241 SFSDTDVHSEVSMFLLGGHDSLAASISWILYCLALNPEHQERCREEVRGILGDGCSITWD 300

SFSD DVHSEVS FLL GHD+LAASISWILYCLALNPEHQERCREEVRGILGDG SITWD

Sbjct: 300 SFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWD 359

Query: 301 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA 343

QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA

Sbjct: 360 QLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA 402

>CYP5A1 (Z. Zhang, N.Adeltawab) partial

ASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQACDLLLAHLKRYAE
SGDAFDIQRCYCNYTTDVVASVAFGTPVDSQQAPEDPFVKHCKRFFEFCIPRPILVLLLS
FPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP
VGVQDFDMVGDVFSSTRCKPNPSRQHQAGPMARPLTVDEIVGQAFIFLIAGYEIVTNTLS
FATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLPYLDMVIAETLRMYPPAF

>CYP5A1 NM_001061 this gene is 197000 bases long
 Length = 534
 
 Score = 576 bits (1484), Expect = e-167
 Identities = 285/297 (95%), Positives = 289/297 (97%)
 
Query: 1 ASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQACDLLLAHLKRYAE 60
 ASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEM PLISQACDLLLAHLKRYAE
Sbjct: 113 ASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAE 172
 
Query: 61 SGDAFDIQRCYCNYTTDVVASVAFGTPVDSQQAPEDPFVKHCKRFFEFCIPRPILVLLLS 120
 SGDAFDIQRCYCNYTTDVVASV FGTPVDS QAPEDPFVKHCKRFFEFCIPRPILVLLLS
Sbjct: 173 SGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLS 232
 
Query: 121 FPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 180
 FPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP
Sbjct: 233 FPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 292
 
Query: 181 VGVQDFDMVGDVFSSTRCKPNPSRQHQAGPMARPLTVDEIVGQAFIFLIAGYEIVTNTLS 240
 +GVQDFD+V DVFSST CKPNPSRQHQ PMARPLTVDEIVGQAFIFLIAGYEI+TNTLS
Sbjct: 293 MGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLS 352
 
Query: 241 FATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLPYLDMVIAETLRMYPPAF 297
 FATYLLATNPDCQEKLLREVD+FKEKHM PEFCSLEEGLPYLDMVIAETLRMYPPAF
Sbjct: 353 FATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAF 409

>CYP7A1 (A.Bolen)

MMTTSLIWGIAIAACCCLWLILGIRRR (2)
QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSY
HKVLCHGKYFDWKKFHFATSAK (0)
AFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN
SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA
LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA
KTHLVVLWASQANTIPATFWSLFQMIR (2)
NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL (1)
DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPL (0)
TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA

IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*

>CYP7A1 NM_000780
 Length = 504
 
 Score = 998 bits (2581), Expect = 0.0
 Identities = 485/504 (96%), Positives = 495/504 (98%)
 
Query: 1 MMTISLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60
 MMT SLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
Sbjct: 1 MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60
 
Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPKDGN 120
 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDP DGN
Sbjct: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120
 
Query: 121 TTENINNTFIKTLQGNALNSLTESMMENLQRIMRPPVFSNSKTAAWVTEGMYSFCYRVMF 180
 TTENIN+TFIKTLQG+ALNSLTESMMENLQRIMRPPV SNSKTAAWVTEGMYSFCYRVMF
Sbjct: 121 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 180
 
Query: 181 EAGYLTIFGRDLTRQDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHSAREKLAE 240
 EAGYLTIFGRDLTR+DTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAH+AREKLAE
Sbjct: 181 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 240
 
Query: 241 SLRHENLQKRESVSELIRLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300
 SLRHENLQKRES+SELI LRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
Sbjct: 241 SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300
 
Query: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQTQLNDLPVLESIIKESLRLSSAS 360
 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQ +LNDLPVL SIIKESLRLSSAS
Sbjct: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLNSIIKESLRLSSAS 360
 
Query: 361 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLSFKYDRYLDENGKTK 420
 LNIRTAKEDFTLHLEDGSYNIRKD IIALYPQLMHLDPEIYPDPL+FKYDRYLDENGKTK
Sbjct: 361 LNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420
 
Query: 421 TTFYCNGLKLKYYYMPFGSGATICPGRVFAIHEIKQFLVLMLSYFELELVEGQDKCPPLD 480
 TTFYCNGLKLKYYYMPFGSGATICPGR+FAIHEIKQFL+LMLSYFELEL+EGQ KCPPLD
Sbjct: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480
 
Query: 481 QSRAGLGILPPLYDIEFKYKFKHL 504
 QSRAGLGILPPL DIEFKYKFKHL

Sbjct: 481 QSRAGLGILPPLNDIEFKYKFKHL 504

>CYP7B1 (G.Zhu) partial

RRPGEPPLIKGWLPYLGVVLKLRKDPLSFMKTLQKQHGDTFTVLLG

GKYITFILDPFQYQLVIKNHKQLSFRLFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN

LKQVFESQLLKTTSWDTAQLYPFCSSIIFEITFTTIYGKVLVCDNKFISELRDDFLKFDD
KFAYLVSNIPIELLGNVKSIRKKIIKCLSSENLAKMQGWSEVFQSRQDVLEKYYVHEDLE
IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL
TREQLDSLICLESTIFEALRLSSYSTTIRFVEEDLTLSAQTGDYCVRKGDLGAIFPPILH
GDPEIFEAPDSKEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEI
KQLLVILLTYFDLEIIDDKPIGLNYNRLLFGIQYPDSDVLFRYKVKS

Alignment of the two sequences, 95%identical

Query: 1 RRPGEPPLIKGWLPYLGVVLKLRKDPLSFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQ 60
 RRPGEPPLIKGWLPYLGVVL LRKDPL FMKTLQKQHGDTFTVLLGGKYITFILDPFQYQ
Sbjct: 41 RRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQ 100
 
Query: 61 LVIKNHKQLSFRLFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN 120
 LVIKNHKQLSFR+FSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN
Sbjct: 101 LVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN 160
 
Query: 121 LKQVFESQLLKTTSWDTAQLYPFCSSIIFEITFTTIYGKVLVCDN-KFISELRDDFLKFD 179
 LKQVFE QLLKTTSWDTA+LYPFCSSIIFEITFTTIYGKV+VCDN KFISELRDDFLKFD
Sbjct: 161 LKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFD 220
 
Query: 180 DKFAYLVSNIPIELLGNVKSIRKKIIKCLSSENLAKMQGWSEVFQSRQDVLEKYYVHEDL 239
 DKFAYLVSNIPIELLGNVKSIR+KIIKC SSE LAKMQGWSEVFQSRQDVLEKYYVHEDL
Sbjct: 221 DKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDL 280
 
Query: 240 EIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIH 299
 EIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIH
Sbjct: 281 EIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIH 340
 
Query: 300 LTREQLDSLICLESTIFEALRLSSYSTTIRFVEEDLTLSAQTGDYCVRKGDLGAIFPPIL 359
 LTREQLDSLICLES+IFEALRLSSYSTTIRFVEEDLTLS++TGDYCVRKGDL AIFPP+L
Sbjct: 341 LTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVL 400
 
Query: 360 HGDPEIFEAPDSKEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALME 419
 HGDPEIFEAP+ EFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALME
Sbjct: 401 HGDPEIFEAPE--EFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALME 458
 
Query: 420 IKQLLVILLTYFDLEIIDDKPIGLNYNRLLFGIQYPDSDVLFRYKVKS 467
 IKQLLVILLTYFDLEIIDDKPIGLNY+RLLFGIQYPDSDVLFRYKVKS
Sbjct: 459 IKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS 506

>CYP8A1 partial (Lin Zhu)

GDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQ (0)

GNMGPAAFWLLLFLLKNPEALAAVRGELESILWEAEQPVSQMTTLPQKVLDGTPVL (1)

DSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE (0)

VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGKSYAVNSIKQ (2)

FVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPIRYRIRP

>CYP8A1 D83402

Length = 500

Score = 553 bits (1424), Expect = e-160

Identities = 270/276 (97%), Positives = 273/276 (98%)

Query: 1 GDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWAT 60

GDKDHMCSVKSRLWKLLSPARLA RAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWAT

Sbjct: 225 GDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWAT 284

Query: 61 QGNMGPAAFWLLLFLLKNPEALAAVRGELESILWEAEQPVSQMTTLPQKVLDGTPVLDSV 120

QGNMGPAAFWLLLFLLKNPEALAAVRGELESILW+AEQPVSQ TTLPQKVLD TPVLDSV

Sbjct: 285 QGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSV 344

Query: 121 LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF 180

LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF

Sbjct: 345 LSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVF 404

Query: 181 KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGKSYAVNSIKQFVFLVLVHLDL 240

KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLG+SYAVNSIKQFVFLVLVHLDL

Sbjct: 405 KYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDL 464

Query: 241 ELINADVEIPEFDLSRYGFGLMQPEHDVPIRYRIRP 276

ELINADVEIPEFDLSRYGFGLMQPEHDVP+RYRIRP

Sbjct: 465 ELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500

>CYP8B1 SCAFFOLD114862:8-613, SCAFFOLD39206:3-626 no introns

BB882888.1 Macaca fasicularis lower case

MVLWGPVLGALLVVIAGYLCLPGMLRQRRPREPPLDKGTVPWLGYAMAFRKNMFEFLKRM

RSKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH

EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLKSKGWSLDASCWHEDSLFHFCYYILFTA

GYLSLFGYTKDKEQDLLQAGEL

40aa gap

shsqxkegisnwlcnmlqflreqgvpsamqdkfnfmmlwasqgntgpts

FWALLFLLKHPEAIRAVRQETTQVLGEARLETKQSFAFKLSALQHTPVLDSVVEETLRLR

AAPTLLRLVHEDYTLKMASGQEYLFRRGDILALFPYLSVHVDPDIHPEPTIFKYDRFLNP

NGSRKVDFFKAGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP

LPHVDPQRWGFGTMQPSHDVRFRYRLRP

Query: 1 MVLWGPVLGALLVVIAGYLCLPGMLRQRRPREPPLDKGTVPWLGYAMAFRKNMFEFLKRM 60

MVLWGPVLGALLVVIAGYLCLPGMLRQRRP EPPLDKGTVPWLG+AMAFRKNMFEFLKRM

Sbjct: 1 MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLGHAMAFRKNMFEFLKRM 60

Query: 61 RSKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH 120

R+KHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH

Sbjct: 61 RTKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH 120

Query: 121 EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLKSKGWSLDASCWHEDSLFHFCYYILFTA 180

EMIHSASTKHLRGDGLKDLNETMLDSLSFVML SKGWSLDASCWHEDSLF FCYYILFTA

Sbjct: 121 EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTA 180

Query: 181 GYLSLFGYTKDKEQDLLQAGEL-------------------------------------- 202

GYLSLFGYTKDKEQDLLQAGEL

Sbjct: 181 GYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQHLFHKML 240

Query: 203 --SHSQXKEGISNWLCNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLFLLK 260

SHSQ KEGISNWL NMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALL+LLK

Sbjct: 241 SVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLK 300

Query: 261 HPEAIRAVRQETTQVLGEARLETKQSFAFKLSALQHTPVLDSVVEETLRLRAAPTLLRLV 320

HPEAIRAVR+E TQVLGEARLETKQSFAFKL ALQHTPVLDSVVEETLRLRAAPTLLRLV

Sbjct: 301 HPEAIRAVREEATQVLGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLV 360

Query: 321 HEDYTLKMASGQEYLFRRGDILALFPYLSVHVDPDIHPEPTIFKYDRFLNPNGSRKVDFF 380

HEDYTLKM+SGQEYLFR GDILALFPYLSVH+DPDIHPEPT+FKYDRFLNPNGSRKVDFF

Sbjct: 361 HEDYTLKMSSGQEYLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFF 420

Query: 381 KAGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW 440

K GKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW

Sbjct: 421 KTGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRW 480

Query: 441 GFGTMQPSHDVRFRYRLRP 459

GFGTMQPSHDVRFRYRL P

Sbjct: 481 GFGTMQPSHDVRFRYRLHP 499

>CYP11A1 N-term = DQ228169.1 Macaca fasicularis = lower case (Mahrous)

mlakglpprsvlvkgcqtflsapkerlghlrvptsegagistrs

prpfneipspgdngwlnlyhfwretgthkvhlhhvqnfqkydpiy

REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK (2)

KSAAWKKDRVALNQEVMAPETTKNFLPLLDAVSRDFVSVLHRRIKKAGSGNFSGDISDDLFRFAFE (1)

SITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK (1)

ADMYTENFHWELRQKGNVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDT (0)

TSMTLQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATMLQLVPLLKASIKETLR (2)

LHPISVTLQRYLVNDLVLRGYMIPAK (0)

TLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN (0)

MLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ

>CYP11A1 NM_000781

Length = 521

Score = 857 bits (2214), Expect = 0.0

Identities = 422/431 (97%), Positives = 428/431 (99%)

Query: 1 REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK 60

REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK

Sbjct: 90 REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKK 149

Query: 61 DRVALNQEVMAPETTKNFLPLLDAVSRDFVSVLHRRIKKAGSGNFSGDISDDLFRFAFES 120

DRVALNQEVMAPE TKNFLPLLDAVSRDFVSVLHRRIKKAGSGN+SGDISDDLFRFAFES

Sbjct: 150 DRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFES 209

Query: 121 ITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAA 180

ITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAA

Sbjct: 210 ITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAA 269

Query: 181 WDVIFSKADMYTENFHWELRQKGNVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVD 240

WDVIFSKAD+YT+NF+WELRQKG+VHHDYRG+LYRLLGDSKMSFEDIKANVTEMLAGGVD

Sbjct: 270 WDVIFSKADIYTQNFYWELRQKGSVHHDYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVD 329

Query: 241 TTSMTLQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATMLQLVPLLKASIKETLRLHP 300

TTSMTLQWHLYEMARNLKVQDMLRAEVLAAR QAQGDMATMLQLVPLLKASIKETLRLHP

Sbjct: 330 TTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHP 389

Query: 301 ISVTLQRYLVNDLVLRGYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY 360

ISVTLQRYLVNDLVLR YMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY

Sbjct: 390 ISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITY 449

Query: 361 FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF 420

FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF

Sbjct: 450 FRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISF 509

Query: 421 TFWPFNQEATQ 431

TFWPFNQEATQ

Sbjct: 510 TFWPFNQEATQ 520

>CYP11B1 (Lin Zhu, S.Hill)

MALRAKAEVCMAAPWLSLQRARALGTRATRVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEHLHLEVHQTFQELGPIFR (2)
YDLGGAGMVCVMLPEDVEKLQQVDSLNPRRMSLEPWVAYRQHRGHKCGVFLL (2)
NGPEWRFNRLRLNPDVLSPRAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIE (1)
ASNLALFGERLGLVGHSPSSASLSFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQY (1)
GDNCIQKIYQELALSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDT (0) 
TVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR (2)
LYPVGLFLERVVSSDLVLQNYHIPAG (0)
TLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH (0)
VLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN

Score = 984 bits (2543), Expect = 0.0
 Identities = 489/503 (97%), Positives = 494/503 (98%)
 
Query: 1 MALRAKAEVCMAAPWLSLQRARALGTRATRVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
 MALRAKAEVCMA PWLSLQRA+ALGTRA RVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
Sbjct: 1 MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQG 60
 
Query: 61 YEHLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLNPRRMSLEPWVAYR 120
 YE LHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSL+P RMSLEPWVAYR
Sbjct: 61 YEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYR 120
 
Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPRAVQRFLPMVDAVARDFSQALRKKVLQNA 180
 QHRGHKCGVFLLNGPEWRFNRLRLNP+VLSP AVQRFLPMVDAVARDFSQAL+KKVLQNA
Sbjct: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180
 
Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLSFLHALEVMFKSTVQLMFM 240
 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASL+FLHALEVMFKSTVQLMFM
Sbjct: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240
 
Query: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELALSRPQQYTSIVAELLLNAELS 300
 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELA SRPQQYTSIVAELLLNAELS
Sbjct: 241 PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS 300
 
Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT
Sbjct: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360
 
Query: 361 ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
 ELPLLRAALKETLRLYPVGLFLERV SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP
Sbjct: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420
 
Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED
Sbjct: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480
 
Query: 481 IKMVYSFILRPSTFPLLTFRAIN 503
 IKMVYSFILRPS PLLTFRAIN
Sbjct: 481 IKMVYSFILRPSMCPLLTFRAIN 503
 

>CYP17 AY746983.1 and AF458332.1

MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP

RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL

DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH

NGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLF

PWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNG

NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQ

NVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHV

IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQ

ELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST

>CYP17 (S. Hill) partial

MWELVALLLFTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQXTTLDILSNNRKGIAFADYGAHW
QLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVISL
ICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLK

>CYP19 (Iyer)
MVLEMLNPMHYNITSMVPEAMPAATMPILLLTGLFLLVWNYEGTSSIP (1)
GPGYCMGIGPLISHGRFLWMGIGSACNYYNQVYGEFMRVWISGEETLIISK (2)
SSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPDLWKTTRPFFMK (1)
ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNMLFLRIPLD (1)
ESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV (2)
KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE (0)
KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIMKEIQTVV (1)
GERDVKIDDMQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG
TNIILNIGRMHRLEFFPKPNEFTLENFAKN (0)
VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVERIQ
KIHDLSSHPDETKNMLEMIFTPRNSDRCLEH
 
>CYP19 NM_000103
 Length = 503
 
 Score = 997 bits (2578), Expect = 0.0
 Identities = 490/503 (97%), Positives = 499/503 (99%)
 
Query: 1 MVLEMLNPMHYNITSMVPEAMPAATMPILLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
 MVLEMLNP+HYNITS+VPEAMPAATMP+LLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60
 
Query: 61 SHGRFLWMGIGSACNYYNQVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
 SHGRFLWMGIGSACNYYN+VYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120
 
Query: 121 GLQCIGMHEKGIIFNNNPDLWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
 GLQCIGMHEKGIIFNNNP+LWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180
 
Query: 181 ESGYVDVLTLLRRVMLDTSNMLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
 ESGYVDVLTLLRRVMLDTSN LFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240
 
Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
 YKKYEKSVKDLKDAIEVLIAEKR RISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300
 
Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIMKEIQTVVGERDVKIDDMQKLKVMENFI 360
 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI+KEIQTV+GERD+KIDD+QKLKVMENFI
Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360
 
Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420
 
Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVERIQKIHDLSSH 480
 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVE IQKIHDLS H
Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480
 
Query: 481 PDETKNMLEMIFTPRNSDRCLEH 503
 PDETKNMLEMIFTPRNSDRCLEH
Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503
 

>CYP21 (Blackwell) partial

LVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGMRDSMEPVVEQLTQEFCERMRAQAGTPV
AIEEEFSLLTCSIICHLTFGDKIKDNLVPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP
NPGLRRLKQAIEKRDHIVEKQLRQHKESLVAGQWRDMMDYMLQVVAQPSMEEGSGQLLEG
HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPSASSSRVPYKDR
ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDEMVWE
RPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPPGDALP
SLQPLPHCSVILKMQPFQVWLQPRGLGVHSLGQSQ

Query: 1 LVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGMRDSMEPVVEQLTQEFCERMRAQAGTPV 60

LVS+NYPDLSLGDYSLLWKAHKKLTRSALLLG+RDSMEPVVEQLTQEFCERMRAQ GTPV

Sbjct: 100 LVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPV 159

Query: 61 AIEEEFSLLTCSIICHLTFGDKIKD-NLVPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF 119

AIEEEFSLLTCSIIC+LTFGDKIKD NL+PAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF

Sbjct: 160 AIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFF 219

Query: 120 PNPGLRRLKQAIEKRDHIVEKQLRQHKESLVAGQWRDMMDYMLQVVAQPSMEEGSGQLLE 179

PNPGLRRLKQAIEKRDHIVE QLRQHKESLVAGQWRDMMDYMLQ VAQPSMEEGSGQLLE

Sbjct: 220 PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLE 279

Query: 180 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPSASSSRVPYKD 239

GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGP ASSSRVPYKD

Sbjct: 280 GHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKD 339

Query: 240 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDEMVW 299

RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE VW

Sbjct: 340 RARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVW 399

Query: 300 ERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPPGDAL 359

ERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP GDAL

Sbjct: 400 ERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 459

Query: 360 PSLQPLPHCSVILKMQPFQVWLQPRGLGVHSLGQSQ 395

PSLQPLPHCSVILKMQPFQV LQPRG+G HS GQ+Q

Sbjct: 460 PSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ 495

>CYP24 (S.Jain) partial

MSSPISKSRSLAAFLQQLRSPRQPPRPVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG




PTSWPLLGSLLQILWKGGLKKQHDTL(0)
VEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR




TESAYPQRLEIKPWKAYRDYRKEGYGLLIL

>CYP24 NM_000782

Length = 513

Score = 295 bits (754), Expect = 6e-83

Identities = 146/150 (97%), Positives = 146/150 (97%), Gaps = 1/150 (0%)

Query: 1 MSSPISKSRSLAAFLQQLRSPRQPPRPVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

MSSPISKSRSLAAFLQQLRSPRQPPR VTSTAYTSPQPREVPVCPLTAGGETQNAAALPG

Sbjct: 1 MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61 PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

PTSWPLL SLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR

Sbjct: 61 PTSWPLLASLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYRKEGYGLLIL 150

TES PQRLEIKPWKAYRDYRKEGYGLLIL

Sbjct: 121 TESV-PQRLEIKPWKAYRDYRKEGYGLLIL 149

>CYP26A1 (Liao, Iyer)

MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDAEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGRGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI

>CYP26A1 NM_000783

Length = 497

Score = 1003 bits (2594), Expect = 0.0

Identities = 493/497 (99%), Positives = 496/497 (99%)

Query: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM

Sbjct: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

Query: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL 120

VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLG+ RLVSVHWPASVRTIL

Sbjct: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGDDRLVSVHWPASVRTIL 120

Query: 121 GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE 180

GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE

Sbjct: 121 GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE 180

Query: 181 VKRLMFRIAMRILLGCEPQLAGDGDAEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR 240

VKRLMFRIAMRILLGCEPQLAGDGD+EQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR

Sbjct: 181 VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR 240

Query: 241 NLIHARIEQNIRAKICGLRASEAGRGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300

NLIHARIEQNIRAKICGLRASEAG+GCKDALQLLIEHSWERGERLDMQALKQSSTELLFG

Sbjct: 241 NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG 300

Query: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360

GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI

Sbjct: 301 GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI 360

Query: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420

KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM

Sbjct: 361 KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM 420

Query: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV 480

LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV

Sbjct: 421 LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV 480

Query: 481 YPVDNLPARFTHFHGEI 497

YPVDNLPARFTHFHGEI

Sbjct: 481 YPVDNLPARFTHFHGEI 497

>CYP26B1 (S.Jain, Penmatsa) partial
VFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP




EEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDY




SDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLR




EELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG




FQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLG




KHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPE




TEAMLSATV

>CYP26B1 AC007002

Length = 512

Score = 727 bits (1876), Expect = 0.0

Identities = 365/369 (98%), Positives = 368/369 (99%)

Query: 1 VFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP 60

VFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP

Sbjct: 144 VFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP 203

Query: 61 EEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDY 120

EEDLGHLFEVYQQFV+NVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDY

Sbjct: 204 EEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDY 263

Query: 121 SDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLR 180

DALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLR

Sbjct: 264 LDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLR 323

Query: 181 EELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG 240

+ELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG

Sbjct: 324 DELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG 383

Query: 241 FQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLG 300

FQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLG

Sbjct: 384 FQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLG 443

Query: 301 KHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPE 360

KHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQN+ILPE

Sbjct: 444 KHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPE 503

Query: 361 TEAMLSATV 369

TEAMLSATV

Sbjct: 504 TEAMLSATV 512

>CYP26C1 (C.Blackwell) missing an exon

MFPWGLSCLSVLGAAGTAVLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLV(0)

QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAV

GEPHRRRRK (0)

VLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDAAKALTFRMAARILLGLRLDEAQCATL

ARTFEQLVENLFSLPLDVPFSGLRK (0)

SAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGCVGPPPDCG
CEPDLSLAALGSLRYVDCVVKEVLRLLPPVSGGYRTALRTFELD(0)

GYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQEL

AQTVLQLLAVELVRTARWELATPAFPALQTVPIVHPVDGLRLFFHPLAPLVAGDGLCL

Query: 1 MFPWGLSCLSVLGAAGTAVLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60

MFPWGLSCLSVLGAAGTA+LCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG

Sbjct: 1 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60

Query: 61 ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS 120

ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS

Sbjct: 61 ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQS 120

Query: 121 AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS 180

AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS

Sbjct: 121 AHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVS 180

Query: 181 VYDAAKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK----- 235

VYDA+KALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK

Sbjct: 181 VYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRKGIRAR 240

Query: 236 ------------------------------------------------SAVELLFAAFFT 247

SAVELLFAAFFT

Sbjct: 241 DQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELKESAVELLFAAFFT 300

Query: 248 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGCVGPPPDCGCEPDLSL 307

TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGG GPPPDCGCEPDLSL

Sbjct: 301 TASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPDCGCEPDLSL 360

Query: 308 AALGSLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV 367

AALG LRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV

Sbjct: 361 AALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDTHETAAV 420

Query: 368 YRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQELAQTVLQLLAVELVRTA 427

YRSPPEGFDPERFGAAREDSRGASSR HYIPFGGGARSCLGQELAQ VLQLLAVELVRTA

Sbjct: 421 YRSPPEGFDPERFGAAREDSRGASSRLHYIPFGGGARSCLGQELAQAVLQLLAVELVRTA 480

Query: 428 RWELATPAFPALQTVPIVHPVDGLRLFFHPLAPLVAGDGLCL 469

RWELATPAFPA+QTVPIVHPVDGLRLFFHPL P VAG+GLCL

Sbjct: 481 RWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL 522

>CYP27A1 (Q.Tran)

QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDLHDLTYGPFTT(2)

EGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMIRLDQLRAESASGNQVSDTAQLFYYFALE (1)

AICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSF (1)

GKKLIDEKLEDMEAQLQAEGPDGVQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDT (0)

TSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHLPLLKAVLKETLR (2)

LYPVVPTNSRIIEKEIEVDGFLFPKN (0)

TQFVFCHYVVSRDPTTFSEPESFQPHRWLRSSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR (0)

LIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC

>CYP27A1 NM_000784
 Length = 531
 
 Score = 897 bits (2319), Expect = 0.0
 Identities = 439/447 (98%), Positives = 442/447 (98%)
 
Query: 1 QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDLHDLTY 60
 QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRD HDLTY
Sbjct: 85 QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTY 144
 
Query: 61 GPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMIRLDQLRAESASGNQVSD 120
 GPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFM RLDQLRAESASGNQVSD
Sbjct: 145 GPFTTEGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSD 204
 
Query: 121 TAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPV 180
 AQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPV
Sbjct: 205 MAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPV 264
 
Query: 181 LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAEGPDGVQVSGYLHFLLASGQLSPRE 240
 LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQA GPDG+QVSGYLHFLLASGQLSPRE
Sbjct: 265 LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPRE 324
 
Query: 241 AMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHLP 300
 AMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAH+P
Sbjct: 325 AMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMP 384
 
Query: 301 LLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTTFSEPESF 360
 LLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPT FSEPESF
Sbjct: 385 LLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESF 444
 
Query: 361 QPHRWLRSSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPE 420
 QPHRWLR+SQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPE
Sbjct: 445 QPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPE 504
 
Query: 421 TGELKSVARIVLVPNKKVGLQFLQRQC 447
 TGELKSVARIVLVPNKKVGLQFLQRQC
Sbjct: 505 TGELKSVARIVLVPNKKVGLQFLQRQC 531

>CYP27B1 (Xin Liu)
MTQTLKYASRVFHRVRWAPELGASLGYREYDSARRSLADIPGPSTPSFLAELFCKGGLSR




LHELQVQGAARFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRRR




QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAETLDNVVRDLVRRLRCQRGRGTGPP




ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH




WLRRLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNRGQPDEDLESGAHLTHFLFQE




ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALGPGSSAHPP




ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA




QFPEPNSFHPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILIHFEVQP




EPGAAPIRPMTRTVLVPERSINLQFLDR
 
>CYP27B1 NM_000785
 Length = 508
 
 Score = 985 bits (2547), Expect = 0.0
 Identities = 489/508 (96%), Positives = 495/508 (97%)
 
Query: 1 MTQTLKYASRVFHRVRWAPELGASLGYREYDSARRSLADIPGPSTPSFLAELFCKGGLSR 60
  MTQTLKYASRVFHRVRWAPELGASLGYREY SARRSLADIPGPSTPSFLAELFCKGGLSR
Sbjct: 1 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 60
 
Query: 61 LHELQVQGAARFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRRR 120
 LHELQVQGAA FGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRR R
Sbjct: 61 LHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCR 120
 
Query: 121 QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAETLDNVVRDLVRRLRCQRGRGTGPP 180
 QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYA TL+NVV DLVRRLR QRGRGTGPP
Sbjct: 121 QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPP 180
 
Query: 181 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH 240
 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
Sbjct: 181 ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH 240
 
Query: 241 WLRRLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNRGQPDEDLESGAHLTHFLFQE 300
 WLR LVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRN GQP++DLESGAHLTHFLF+E
Sbjct: 241 WLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFRE 300
 
Query: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALGPGSSAHPP 360
 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAAL PGSSA+P 
Sbjct: 301 ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPGSSAYPS 360
 
Query: 361 ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA 420
 ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
Sbjct: 361 ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA 420
 
Query: 421 QFPEPNSFHPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILIHFEVQP 480
 QFPEPNSF PARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQIL HFEVQP
Sbjct: 421 QFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP 480
 
Query: 481 EPGAAPIRPMTRTVLVPERSINLQFLDR 508
  EPGAAP+RP TRTVLVPERSINLQFLDR
Sbjct: 481 EPGAAPVRPKTRTVLVPERSINLQFLDR 508

>CYP27C1 (F.Zhang) partial
MQTSAMALLARILRAGLRPAPERGGLLGGAAPRRPQPAGARLPAGARAEDKGAGRPGAPP




AGGRAEGPRLAAMPGPRTLANLAEFFYRDGFSRIHEIQQKHT




QEYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISA




EGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLF




FKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIP




KPWREFCRSWDGLFKF
 
>CYP27C1 AC027142 43% identical to 27A1 assembled gene
 Length = 542
 
 Score = 586 bits (1511), Expect = e-170
 Identities = 293/301 (97%), Positives = 296/301 (98%), Gaps = 1/301 (0%)
 
Query: 1 MQTSAMALLARILRAGLRPAPERGGLLGGAAPRRPQPAGARLPAGARAEDKGAGRPGAPP 60
 MQTSAMALLARILRAGLRPAPERGGLLGG APRRPQPAGARLPAGARAEDKGAGRPG+PP
Sbjct: 1 MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPP 60
 
Query: 61 AGGRAEGPR-LAAMPGPRTLANLAEFFYRDGFSRIHEIQQKHTQEYGKIFKSHFGPQFVV 119
 GGRAEGPR LAAMPGPRTLANLAEFF RDGFSRIHEIQQKHT+EYGKIFKSHFGPQFVV
Sbjct: 61 GGGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVV 120
 
Query: 120 SIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRIL 179
 SIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRIL
Sbjct: 121 SIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRIL 180
 
Query: 180 KPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRL 239
 KPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRL
Sbjct: 181 KPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRL 240
 
Query: 240 GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFK 299
 GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKF 
Sbjct: 241 GCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFS 300
 

>CYP39 (Q.Tran)

MELIFPTVIIILGCLALFLLLQRKNLRRPPCIRGWIPWIGVGFEFGKAPLEFIEKARIK (0)

YGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYHT (1)

ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLV (2)

RHLLYPVTVNTLFNKSWFPTNKKKIKEFHQYFQAYDEDFEYGSQLPECLL (2)

RNWSKSKKWFLELFEKNIPDIKACKSAKDNSM (0)

TLLQATLDIVETETSKENSPNYGLLLLWASLSNAVP(0)

VAFWTLAYVLSHPDIHKAVMEGISSVFGTA (1)

GKDKIKVSEDDLEKLLLIKWCVLETIRLKAPGVITRKVVKPVEIL (0)

NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKP (0)

ERWKKANLEKHSFLDCFVAFGSGKFQCPG (2)

RWFALLEVQMCVILILYKYDCSLLDPLPKQ (0)

SSLHLVGVPQPEGQCRIEYKQRI

>CYP39A1 AC008104 AL035670 note heme region exon corrected 1/18/02
 Length = 469
 
 Score = 934 bits (2413), Expect = 0.0
 Identities = 455/469 (97%), Positives = 459/469 (97%)
 
Query: 1 MELIFPTVIIILGCLALFLLLQRKNLRRPPCIRGWIPWIGVGFEFGKAPLEFIEKARIKY 60
 MELI PTVIIILGCLALFLLLQRKNLRRPPCI+GWIPWIGVGFEFGKAPLEFIEKARIKY
Sbjct: 1 MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKY 60
 
Query: 61 GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYHTASIPKNVFLALHEKLY 120
 GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVY TASIPKNVFLALHEKLY
Sbjct: 61 GPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLY 120
 
Query: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNTLFNKSWF 180
 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVN LFNKS F
Sbjct: 121 IMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF 180
 
Query: 181 PTNKKKIKEFHQYFQAYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK 240
 TNKKKIKEFHQYFQ YDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK
Sbjct: 181 STNKKKIKEFHQYFQVYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAK 240
 
Query: 241 DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAVM 300
 DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKA+M
Sbjct: 241 DNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIM 300
 
Query: 301 EGISSVFGTAGKDKIKVSEDDLEKLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP 360
 EGISSVFG AGKDKIKVSEDDLE LLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP
Sbjct: 301 EGISSVFGKAGKDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIP 360
 
Query: 361 SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFVAFGSGKFQCPGRWFA 420
 SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCF+AFGSGKFQCP RWFA
Sbjct: 361 SGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFA 420
 
Query: 421 LLEVQMCVILILYKYDCSLLDPLPKQSSLHLVGVPQPEGQCRIEYKQRI 469
 LLEVQMC+ILILYKYDCSLLDPLPKQS LHLVGVPQPEGQCRIEYKQRI
Sbjct: 421 LLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI 469
 
>CYP46 C-term part (Ramy.Naguib)
RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP




 
GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME




 
VKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPTPPPPPC
 
Alignment of the two proteins Identities = 173/174 (99%), Positives = 173/174 (99%), Gaps = 0/174 (0%)
 
Query 1 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP 60
 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP
Sbjct 327 RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP 386
 
Query 61 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME 120
 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME
Sbjct 387 GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME 446
 
Query 121 VKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPTPPPPPC 174
 VKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQP PPPPPC
Sbjct 447 VKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC 500
 
>CYP51 (Y.Peng) partial
AAAAGMMLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLPAG (0)
KSPPYIFSPIPFLGHAIAFGKSPVEFLENAYEK (0)
VFGKGVAYDVPNP (0)
VFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFQSWGESGEK (1)
VFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSF (2)
RRRDRAHREIKNIFYKAIQKRRQSQEKIDDILQTLLDATYK (0)
DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKT 




VCGENLPPLTYDQ (0)
TVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE




KFAYVPFGA (1)
GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
 
Score = 2176 (766.0 bits), Expect = 5.2e-231, P = 5.2e-231
 Identities = 422/428 (98%), Positives = 423/428 (98%)
 
Query: 1 AAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYL-RLAAGHLVQLP 59
 AAAAGM+LLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYL RLAAGHLVQLP
Sbjct: 1 AAAAGMMLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLP 60
 
Query: 60 AGKSPPYIFSPIPFLGHAIAFGKSP-EFLENAYEKVFGKGVAYDVPNPVFLEQKKMLKSG 118
 AGKSPPYIFSPIPFLGHAIAFGKSP EFLENAYEKVFGKGVAYDVPNPVFLEQKKMLKSG
Sbjct: 61 AGKSPPYIFSPIPFLGHAIAFGKSPVEFLENAYEKVFGKGVAYDVPNPVFLEQKKMLKSG 120
 
Query:  119 LNIAHFKQHVSIIEKETKEYF-SWGESGEKVFEALSELIILTASHCLHGKEIRSQLNEKV 177
 LNIAHFKQHVSIIEKETKEYF SWGESGEKVFEALSELIILTASHCLHGKEIRSQLNEKV
Sbjct: 121 LNIAHFKQHVSIIEKETKEYFQSWGESGEKVFEALSELIILTASHCLHGKEIRSQLNEKV 180
 
Query: 178 AQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIK-IFYKAIQKRRQSQEKIDDILQ 236
 AQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIK IFYKAIQKRRQSQEKIDDILQ
Sbjct: 181 AQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRQSQEKIDDILQ 240
 
Query: 237 TLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ-KCYLEQKT 295
 TLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ KCYLEQKT
Sbjct: 241 TLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKT 300
 
Query: 296 VCGENLPPLTYDQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE 355
  VCGENLPPLTYDQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE
Sbjct: 301 VCGENLPPLTYDQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE 360
 
Query: 356 KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 415
 KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV
Sbjct: 361 KFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV 420
 
Query: 416 IRYKRRSK 423
 IRYKRRSK
Sbjct: 421 IRYKRRSK 428
 
 
 
FASTA format of assembled sequences

>CYP1A1

MLFRISMSATEFLLASLIFCLVFWVIRASRPRVPKGLKNPPGPW

GWPLIGHILTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVQQGDD

FKGRPNLYSFTLISNGQSMSFGPDSGPVWAARRRLAQNGLKSFSIASDPASSSSCYLE

EHVSKEAEVLISKLQEQMAGPGHFNPYRYVVISVANVICAICFGQRYDHNHQELLSLV

NLSNNFGEVVGSGNPADFIPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKG

HIRDITDSLIEHCQEKQLDENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLV

TNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR

DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFITPDGAIDKVLSEKVILF

GLGKRKCIGETIARWEVFLFLAILLQRVEFSVPPGVKVDMTPIYGLTMKHACCEHFQM

QLRS

>CYP1A2 (Aggarwal)

MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG
QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP
ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDK (0)
NSVQDITGALFKHSKKGPRASGNLIPQEKTVNLVNDIFGA (1)
GFDTIATAISWSLMYLVTKPEIQRKIQKEL (1)
DAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFTIPH (2)
STTRDTTLNGFYIPRECCVFINQWQVNHDP (2)
QLWGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHFQAR
 

>CYP1A8P ortholog possibly a functional gene in rhesus

MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL

TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL

SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN

GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR

YLPLQIINAPREFYRALNGFIALHVQDHLATYDK (0)

DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVNDLFGA (1)

GFETVSTCLYWSFLYLIHYPEIQAKIQEEI (1)

DGNIGLKPPRFEDRKILPYTEAFISEVFRHASFLPFTIPHC (2)

TTADTTLNGYFIPRKTCTFINMYQVNHDE (2)

TIWDNPSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQL

KLKKCPRAKLDLTPTYGLVMRPKPYQLEAERRSSGSSSA

>CYP1B1

MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI

GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF

ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL

LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA

EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIR (2)

YPDVQARVQAELDQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTS

VLGYHIPKDTVIFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKR

RCIGEELSKMQLFLFISILAHQCNFRANPNGPEMNFSYGLTIKPKSFKVNVTLRESMELL

DSAVQKLQAEETCQ

>CYP2A24 AY635460

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMCNSLMKISERYGPVFTIHLGPRRVVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLGMMLGSFQFTSTSTGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQHTLDPNSPRDFIDSFLIRMQ

EEEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVEAKVHEEIDRV

IGKNRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPKGTEVF

PMLGSVLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF

LFFTTIMQNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR

>CYP2A23 AY635459.1

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMYNSIMKISERYGPVFTIHLGPRRIVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWLFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTQGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSAGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNRRTLDPNSPRDFIDSFLIRMQ

EEEKNPNTEFHLKNLVLTSLNLFFGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV

IGKNRQPKFEDQARMPYMEAVIHEIQRFGDMLPLGVAHRVIKDTKFRDFFLPKGTEVF

PMLGSVLKDPKFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF

LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPPNYTMSFLPR

>CYP2C43 AB212264.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKLPPGPTPLPVIGNILK

IGIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

FERANRRFGLVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKFNENAKILSSPWIQIYNN

FSPIIDYFPGTHNKLLKNIAFVKSYILEKVKEHQESMDMNNPRDFIDCFLIKMEKEKH

NQQSEFNIENLENTAVDLFAAGTETTSTTLRYALLLLLKHPEVAAKVQEEIEHVIGRN

RSPCMQDRSRMPYTDAVVHEIQRYIDLLPTSVPHAVTCDVKFRNYLIPKGTTILISLT

SVLRDNKEFPNPEMFDPRHFLDEGGNFKNSNYFMPFSAGKRICVGEALARMELFLFLT

SILQNFNLKSLVDLKDLDTTPVFNGFVSVPPIYQLCFIPV

>CYP2C74 variant (S.Sarva) missing exon 1, 4 aa diffs to 2C74 AY635462.1
FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGL (1)
GIISSNGKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTK (1)
ASPCDPTFILGCAPCNVICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQ (0)
VCNNFPLLIDCFPGTHNKLLKNVALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQ (0)
EKDNQQSEFTIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT (1)
AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQRYIDLVPTGVPHAVTTDIKFRNYLIPK (0)
GTIIITLLTSVLQDDKEFPNPKIFDPGHFLDENGNFKKSDYFMPFSA (1)
GKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGIISLPPSYQICFIPV

>CYP2C75 AY635463.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKFPPGPTPLPVIGNILQ

IDIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

ADRANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

GSPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLKVMEKLNENVKILSSPWIQICNN

FPPFIDYFPGAHNKLLKNIAFLKSYILEKVKEHQESMDMNNPRDFIDCFLMKMEKEKH

NQQSEFTIENLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN

RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFRNYLIPKGTTILISLT

SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEALARMELFLFLT

SVLQNFNLKSLVDPKDLDTTPVVNGFASVPPFYQLCFIPV

>searched with 2C29 differs from 2C43, 2C74, 2C75 (Liao)

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV

YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW

KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS

VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ

>CYP2B30 (Puljic) also AY635461.1

MELSVLLFLALLTGLLLLLVQRHPNAHGRLPPGPCPLPLLGNLL

QMDRRGLLRSFLRFREKYGDVFTVYLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIA

ITDPVFQGYGVVFANGNRWKVLRRFSLTTMRDFGMGKRSVEERIQEEAQCLIEELRKS

KGALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFE

LLSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEK

SNPHSEFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERIYKEIEQVIGP

HRPPALDDRAKMPYTEAVIHEIQRFADLLPMGVPHIVTQQTSFRGYIIPKDTEVFPLL

STALHDPHYFEKPDTFNPDHFLDANGALKKNEAFIPFSLGRRMCLGEGIARNELFLFF

TTILQNFSVASPVAPEDIDLTPQESGVGKIPPTYQIRFLPR

>CYP2F6 AY952296.1

MDSISTAILLLLLALVCLLLTLSSRDKXKLPPGPRPLPLLGNLLLLRSQNMLTSLTQ

LSKEYGSVYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPVFFNFTKGN

GIAFSNGDRWKVLRRFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTE

GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTVIRLINDNFQIMSSPWGE (0)

LYNIFPSLLDWVPGPHQRIFQNFKRLRDLIAHRVHDQQASLDPRSPRDFIDCFLTKMAE

EKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQ

ARVQEEIDLVVGRTRLPTLEDRAAMPYTDAVIHEVQRFADIIPMNLPHRVIRDTAFRXFLIPK

GTDIITLLNTVHYDPSQFLXPQEFNPEHFLDANQSFKKSPAFMPFSA

GRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRSFQLCLCPR

>CYP2D42 (Vasser) also AY635464.1

MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ (0)

LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQ (1)

GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQA (1)

GRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLRE (0)

VLNAVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK (0)

AKGNPESSFNEENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR (1)

RVQQEIDNVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIELQGFLIPK (0)

GTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA (1)

GRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGVFAFLVTPSPYELCAVPR*

>CYP2E1 AY635465.1

MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGN

LFQLELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGD

IPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK

TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFQLLSTPWLQLY

NNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKE

KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG

PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPT

LDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLL

LSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS

>CYP2G2P best hit (Li Chen) Note this does not look like a pseudogene
MELGGAVTIFLALCLSCLLVLIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK (0)
LKEKYGPLFTVYMGLWPVVVLCGHEAVKEALIDQADEFSGRGKLASIEQNFQGH (1)
GVALANGERWRILRRFSLTILRDFGMGKRSIEERILEEASYLLEEFRKTK (1)
GAPIDPTFLLSRTVSNVISSVVFGSRFDYEDKQFLNLLRLINESFIEMSTPWAQ (0)
LYDMYSGIMQYLPGRHNRVYYLIEQLKDFIASRVKINEASFDSQNPRDFIDCFLIKMHQ (0)
DKNNPRTEFNLKNLVLTALNLFFAGTETVSSTLRYGFLLLMKHPEVE (1)
ARIHEEINQVIGPHRLPSVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNVIRDTQFRGYLLPK (0)
GTDVFPLLGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNEAFVPFSS (1)
GKRICLGEAMARMELFLYFTSILQNFSPRSLVPPADIDITPKLSGFGNIPPTYELCLVAR

>CYP2J2 best hit (Z. Zhang) partial

GLIMSSGQIWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKI
NNAVSNIICSITFGERFDYQDSQFQELLKLLDEVTYLEASKTCQLYNIFPWLMKFLPGPH
QTLFSNWEKLKLFVSHMIEKHRKDWNPAETRDFIDAYLKEMSKHTGNSTSSFHEENLICS
TLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNA
VIHEVQRMGNIVPLNVPREVTVDTTLAGYHLPKRACLGEQLARTELFIFFTSLVQKFTFR
PPNNEKLSLKFRMGITISPVSHHLC

>CYP2R1 (G.Zhu) partial

IFSLDLGGISTVVLNGYDVVKECLVHQSGIFADRPCLPLFMKMTKMGGLLNSRYGQGWVE
HRRLAVNSFRYFGYGQKSFESKILEETKFFTDAIETYKGRPFDFKQLITSAVSNITNLII
FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNASVVYD
FLSRLIEKASVNRKPQLPQHFVDAYFDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT
TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKFKMPYTEAVLHEVLRFCNIV
PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK
EALVPFSLGRRHCLGEQLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL
ICAERR

>CYP2S1 AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13

exons 2,3 from CO649282.1

MEATGTWALLLALALLLLLTLALSGTRARGQLPPGPTPLPLLGNLLQLRPGALYSGLMR (0)

LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH (1)

GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE (1)

GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAMVRAAGGTLLGVSSRGGQ (0)

TYEMCSWFLWPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ (0)

EEQNPDTEFTNKNMLMTVIYLLFAGTMTVSATVGYTLLLLMKYPHVQ (1)

KRVREELTQELGSGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ (0)

GTEVFPLLGSILHDPSIFKHPEEFNPDHFLDADGRFRKHEAFLPFSL (1)

GKRVCLGEGLAKAELFLFFTTILQAFSLESPCPLDSLSLKPTISGLFNIPPAFQLQVRPTDLHSTTQTT*

>CYP2T2P ortholog, SCAFFOLD100362 (+) 38209-41795

frameshift in exon 4 after VIC, numerous other defects

MIAGIAALLLWLLVLALARWG*GGCRARMRGSLPPRPRPLPLLGNLQLQSGGTDHALHS (?)

LSGRWGPVFTAQLGPRPAVVLCGYAALRDALVLQADAFSGRGSMAVFERFTRGH (1)

GIFLSNGPRWWTLRNFAVGALKELGLGTRTIQAHVLEEAACLLDEMQATI (1)

GAPFDPMRLLDNAVSNVICX

LVFGNRYGYGDPEFLRLLNLFSDNFRIMSSRWGE (0)

(?) SLMDWLPGRHRRIFRNF

SELWVFISEQIQQHWQMRQPAEPRDFINCLTRWVRRGSQ

QDPESHFQEETSVMMTHLFFGGTETSTTLCYGLLVLLKYPEVA (1)

AKVQELDPVVGWRCAPSPDDHQRLPYTNAVLLQIQRFISVVPLGLPRX

TLNTHLHSHCLPK (1)

GTFVIPLLVTAHXDRTQFKDPDCFNATNFLDKGKSQGNDPFMPFAS (1)

(?) GKQMCLGAGLAHLEIFLFLTATLPRFRLLPVVNPGTINLT

QFTGLGSVPPAFQLQLVAC

>CYP2U1 (li Chen) note gc boundary between exons 7,8
MSSPGPPQPPAEDPPWPARLLRAPLGLLRMDPSGDALLLCGLVAVLGWSWLRRRRARGIP PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVVGPQVLLAHLARVYGSIFSF FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEK (1)
GVVFAHYGPIWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI
ISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLMVNICPWLYYLPFGP
FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLF
YIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ (1)
EKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSGNT (1)
VLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGI (1)

GKRVCMGEQLAKMELFLMFVSLMQSFAFALPEKSKKPLLTGRFGLTLAPHPFNITISRR*

>CYP2W1 Macaca mulatta rhesus monkey (Mahrous)

LSERYGPVFTVHLGCQKTVVLTGFEVVKEALAGPGQELADRPPIAIFQLIQRGG (1)

GIFFSSGARWRAARQFTVRALHSLGVGRKPVADKILQELKCLLGQLDGYR (1)

GQPFPLALLGWAPSNITFTLLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQ (0)

LFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHMRPGDPVCSYVDALIQQGQ (0)

GDDPEGLFAEDNAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQ (1)

GRVQEELDRVLRRGRPPQPEDQQVLPYTSAVLHEVQRFITLLPHVPRCTATDMQLGGFLLPK (0)

GTPVIPLLTSVLLDETQWQTPDQFNPGHFLDADGHFVKQEAFLPFSA (1)

GRRVCVGERLARTELFLLFAGLLQKYYLLPPPGVSPASLDTTPAQAFTMRPRAQALCAVPRP

>CYP2AB1P SCAFFOLD46808:34-204, SCAFFOLD101629:758-8003 (no ESTs found)

MLSLLSGLALLAISFLLLKLGTFCWDRNRLPPGPFPFPILGNLWQLRFQLHPETLLQ (0)

LAQTHG

VCLFTVWVSPIPIVVLSGFRAVKEALVSNSEQFSGRPLTSLFQDLFGEQ (1)

GIVCSRRHMWWQQRRFCLVTLQGLGLGKLALEVQLQKQAAELVEAFRQEL (1)

SRSFDPQVSIVRSTVRVIGALVFGHHFLSEDPIFQELTQAIDFGLALVRTVWHW (0)

LHDVFPRALCHLPGSHREIFRYQGVVRSFTRREITGRKLKALEALKDFINCSLAQISK (0)

AMDEPVSTFHEENLVQVVIDLFLGGTNTTATTQRWALVYMIQHGAVQ (1?)

GTIILPLCRGSVLYDPECWETPPQFNPGHFLDKDGNFVANEAFLPFSA (1)

GHCVCPGDQLARMELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGTLQPQPQEICAVPR

>CYP2AC1P SCAF55146 (+) 91919-103589, SCAF70822:43519-43602, SCAF103481:817-966

1 MSEFDASAILPIRVLILIFILSIKKFMTEASKQLSPPGPRPLLVIGNLYFLNLKRPYQTMLE (0)

3 GIAFFHGETWKTMRWFSLTTLQNFGMDEWIIEDTIIEECQNLIQNSEFHR

4 GKSFEMKTIMNASVVNIIVLVLPGKWFDYQDSQFLRLLALIGENVKLIGGLRIAVN (1)

5 SFQYVSFWGVLLKSHKTVFRNRDELFSFIRMIFLDHCHKLDKNDPRSFTDAFLVTQQE (0)

6 ENDTFADHFSDENLMALVNNLFTTGTETTASTLPWGILLVICLRSRV (1)

7 KKVHNEVTKVARSAQP*LAHQTQMPHTDAVSHEVQRFANILPTSLPHATPTNIFKNYYIPK (0)

8 ATEVIILLASVRRDQAQWEKPDTFNPEHFLTSKGKFIKREAFLPFTV (1)

9 GRRMCAGESSAR MELFLFFTSLLQ KFTFQPPLGVSHLDLDLSLDIGFTT*

>CYP3A64 AY582531.1

MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL

PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF

TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL

RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP

FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI

DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE

IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV

VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM

NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA

>CYP3A43 ortholog? partial assembly (Aggarwal) 72% to 3A64
MDLIPNFAMETWVLVATSLVLL (2)
YIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLR (0)
GLWKFDRECNEKYGEMWG (2)
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNRM (0)
PLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKE (0)
MVPIISQCGDMLVRSLRREAENSKPTNLKE

>CYP4A11 match (ramy.Naguib, Puljic) (exon 1 added later)
MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLFGHKQE (0)
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS (1)
DPKSQDPYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML (0)
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK (1)
GITVMLSIYGLHHNPKVWPNPE (0)
VFDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

>CYP4B1

MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE (0)

IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG (1)

DPKAPDVYDFFLQWI (1)

GRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML (0)

DKWEEKAQEGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHR (2)

DSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLTPHGRRFLRACQVAHDHT (1)

DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR (0)

DEDDSKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQW (2)

DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA (1)

GSLISMHIYALHRNSAVWPDPE (0)

VFDPLRFSTENASKRHPFAFMPFSAGPR (2)

NCIGQQFAMSEMKVVTAMCLLHFEFSLDPSRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK

>CYP4V2 (S.Sarva)
MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV 
GHALLMKRDGR (1)
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE (0)
VILTSSKQIDKSSMYKFLEPWLGLGLLTS (2)
TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHVNQEAFNCFVYITLCALDIIC (1)
ETAMGKNIGAQSNDDSEYVRAVYR (2)
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHAFTNN (0)
VIAERANEMNVDEDCRGDGRDSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE (0)
GHDTTAAAMNWSLYLLGSNPEVQKKVDHELDDVF (1)
GRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV (1)
AGYRVLKGTEAV
IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCI (1)
GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 1551

>CYP4X1 (Vasser) missing exon 1

FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTFLSRT (1)

DPKSQYLQKFLPPLI (1)

GKGLLALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKTML (0)

DKWEKICSTQNTSVEVYEHINLMSLDIIMKCAFSKETNCQTN (2)

STHDPYVKAIFELGKIIFHRLYSFLYHSDIIFKLSPQGYRFQKLSRVLNQYT (1)

DAIIQERKKSLQAGEKQDNTQKRKYQDFLDIVLSAK (0)

DENGSSFSDTDVHSEVSMFLLGGHDSLAASISWILYCLALNPEHQERCREEVRGILGDGCSITW (2)

DQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPA*

>CYP5A1 (Z. Zhang) partial

ASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQACDLLLAHLKRYAE
SGDAFDIQRCYCNYTTDVVASVAFGTPVDSQQAPEDPFVKHCKRFFEFCIPRPILVLLLS
FPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP
VGVQDFDMVGDVFSSTRCKPNPSRQHQAGPMARPLTVDEIVGQAFIFLIAGYEIVTNTLS
FATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLPYLDMVIAETLRMYPPAF

>CYP7A1 (A.Bolen)

MMTTSLIWGIAIAACCCLWLILGIRRR (2)

QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSY

HKVLCHGKYFDWKKFHFATSAK (0)

AFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN

SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA

LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA

KTHLVVLWASQANTIPATFWSLFQMIR (2)

NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL (1)

DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPL (0)

TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA

IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*

>CYP7B1 (G.Zhu) partial

RRPGEPPLIKGWLPYLGVVLKLRKDPLSFMKTLQKQHGDTFTVLLG

GKYITFILDPFQYQLVIKNHKQLSFRLFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN

LKQVFESQLLKTTSWDTAQLYPFCSSIIFEITFTTIYGKVLVCDNKFISELRDDFLKFDD
KFAYLVSNIPIELLGNVKSIRKKIIKCLSSENLAKMQGWSEVFQSRQDVLEKYYVHEDLE
IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL
TREQLDSLICLESTIFEALRLSSYSTTIRFVEEDLTLSAQTGDYCVRKGDLGAIFPPILH
GDPEIFEAPDSKEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCPGRFFALMEI
KQLLVILLTYFDLEIIDDKPIGLNYNRLLFGIQYPDSDVLFRYKVKS

>CYP8A1 partial (Lin Zhu)

GDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQ (0)

GNMGPAAFWLLLFLLKNPEALAAVRGELESILWEAEQPVSQMTTLPQKVLDGTPVL (1)

DSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPE (0)

VFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGKSYAVNSIKQ (2)

FVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPIRYRIRP

>CYP8B1 SCAFFOLD114862:8-613, SCAFFOLD39206:3-626 no introns

BB882888.1 Macaca fasicularis lower case

MVLWGPVLGALLVVIAGYLCLPGMLRQRRPREPPLDKGTVPWLGYAMAFRKNMFEFLKRM

RSKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDH

EMIHSASTKHLRGDGLKDLNETMLDSLSFVMLKSKGWSLDASCWHEDSLFHFCYYILFTA

GYLSLFGYTKDKEQDLLQAGEL

40aa gap

shsqxkegisnwlcnmlqflreqgvpsamqdkfnfmmlwasqgntgpts

FWALLFLLKHPEAIRAVRQETTQVLGEARLETKQSFAFKLSALQHTPVLDSVVEETLRLR

AAPTLLRLVHEDYTLKMASGQEYLFRRGDILALFPYLSVHVDPDIHPEPTIFKYDRFLNP

NGSRKVDFFKAGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTP

LPHVDPQRWGFGTMQPSHDVRFRYRLRP

>CYP11A1 N-term = DQ228169.1 Macaca fasicularis = lower case (Mahrous)

mlakglpprsvlvkgcqtflsapkerlghlrvptsegagistrs

prpfneipspgdngwlnlyhfwretgthkvhlhhvqnfqkydpiy

REKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLK (2)

KSAAWKKDRVALNQEVMAPETTKNFLPLLDAVSRDFVSVLHRRIKKAGSGNFSGDISDDLFRFAFE (1)

SITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK (1)

ADMYTENFHWELRQKGNVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDT (0)

TSMTLQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATMLQLVPLLKASIKETLR (2)

LHPISVTLQRYLVNDLVLRGYMIPAK (0)

TLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLIN (0)

MLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQ

>CYP11B1 (Lin Zhu)

MALRAKAEVCMAAPWLSLQRARALGTRATRVPRTVLPFEAMPRRPGNRWLRLLQIWREQG
YEHLHLEVHQTFQELGPIFR (2)
YDLGGAGMVCVMLPEDVEKLQQVDSLNPRRMSLEPWVAYRQHRGHKCGVFLL (2)
NGPEWRFNRLRLNPDVLSPRAVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIE (1)
ASNLALFGERLGLVGHSPSSASLSFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQY (1)
GDNCIQKIYQELALSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDT (0) 
TVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR (2)
LYPVGLFLERVVSSDLVLQNYHIPAG (0)
TLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH (0)
VLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN

>CYP17 AY746983.1 and AF458332.1

MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP

RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL

DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH

NGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLF

PWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNG

NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQ

NVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHV

IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQ

ELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST

>CYP19 (Iyer)

MVLEMLNPMHYNITSMVPEAMPAATMPILLLTGLFLLVWNYEGTSSIP (1)

GPGYCMGIGPLISHGRFLWMGIGSACNYYNQVYGEFMRVWISGEETLIISK (2)

SSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPDLWKTTRPFFMK (1)

ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNMLFLRIPLD (1)

ESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV (2)

KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE (0)

KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIMKEIQTVV (1)

GERDVKIDDMQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG

TNIILNIGRMHRLEFFPKPNEFTLENFAKN (0)

VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVERIQ

KIHDLSSHPDETKNMLEMIFTPRNSDRCLEH

>CYP21 (Blackwell) partial

LVSKNYPDLSLGDYSLLWKAHKKLTRSALLLGMRDSMEPVVEQLTQEFCERMRAQAGTPV

AIEEEFSLLTCSIICHLTFGDKIKDNLVPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP

NPGLRRLKQAIEKRDHIVEKQLRQHKESLVAGQWRDMMDYMLQVVAQPSMEEGSGQLLEG

HVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPSASSSRVPYKDR

ARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDEMVWE

RPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPPGDALP

SLQPLPHCSVILKMQPFQVWLQPRGLGVHSLGQSQ

>CYP24 (S.Jain) partial

MSSPISKSRSLAAFLQQLRSPRQPPRPVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTL(0)
VEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLIL

>CYP26A1 (Liao, Iyer)

MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM

VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL

GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE

VKRLMFRIAMRILLGCEPQLAGDGDAEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR

NLIHARIEQNIRAKICGLRASEAGRGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG

GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI

KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM

LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV

YPVDNLPARFTHFHGEI

>CYP26B1 (S.Jain) partial
VFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIP
EEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDY
SDALDLLIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLR
EELRAHGILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDG
FQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLG
KHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPE
TEAMLSATV

>CYP26C1 (C.Blackwell) missing an exon

MFPWGLSCLSVLGAAGTAVLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLV(0)

QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAV

GEPHRRRRK (0)

VLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDAAKALTFRMAARILLGLRLDEAQCATL

ARTFEQLVENLFSLPLDVPFSGLRK (0)

SAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGCVGPPPDCG
CEPDLSLAALGSLRYVDCVVKEVLRLLPPVSGGYRTALRTFELD(0)

GYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRFHYIPFGGGARSCLGQEL

AQTVLQLLAVELVRTARWELATPAFPALQTVPIVHPVDGLRLFFHPLAPLVAGDGLCL

>CYP27A1 (Q.Tran)

QVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDLHDLTYGPFTT(2)

EGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMIRLDQLRAESASGNQVSDTAQLFYYFALE (1)

AICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSF (1)

GKKLIDEKLEDMEAQLQAEGPDGVQVSGYLHFLLASGQLSPREAMGSLPELLMAGVDT (0)

TSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHLPLLKAVLKETLR (2)

LYPVVPTNSRIIEKEIEVDGFLFPKN (0)

TQFVFCHYVVSRDPTTFSEPESFQPHRWLRSSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLAR (0)

LIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC

>CYP27B1 (Xin Liu)
MTQTLKYASRVFHRVRWAPELGASLGYREYDSARRSLADIPGPSTPSFLAELFCKGGLSR
LHELQVQGAARFGPVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRRR
QRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAETLDNVVRDLVRRLRCQRGRGTGPP
ALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPH
WLRRLVPGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNRGQPDEDLESGAHLTHFLFQE
ELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALGPGSSAHPP
ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPA
QFPEPNSFHPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQILIHFEVQP
EPGAAPIRPMTRTVLVPERSINLQFLDR
 
>CYP27C1 (F.Zhang) partial
MQTSAMALLARILRAGLRPAPERGGLLGGAAPRRPQPAGARLPAGARAEDKGAGRPGAPP
AGGRAEGPRLAAMPGPRTLANLAEFFYRDGFSRIHEIQQKHT
QEYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISA
EGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLF
FKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIP
KPWREFCRSWDGLFKF

>CYP39 (Q.Tran)

MELIFPTVIIILGCLALFLLLQRKNLRRPPCIRGWIPWIGVGFEFGKAPLEFIEKARIK (0)

YGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYHT (1)

ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLV (2)

RHLLYPVTVNTLFNKSWFPTNKKKIKEFHQYFQAYDEDFEYGSQLPECLL (2)

RNWSKSKKWFLELFEKNIPDIKACKSAKDNSM (0)

TLLQATLDIVETETSKENSPNYGLLLLWASLSNAVP(0)

VAFWTLAYVLSHPDIHKAVMEGISSVFGTA (1)

GKDKIKVSEDDLEKLLLIKWCVLETIRLKAPGVITRKVVKPVEIL (0)

NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKP (0)

ERWKKANLEKHSFLDCFVAFGSGKFQCPG (2)

RWFALLEVQMCVILILYKYDCSLLDPLPKQ (0)

SSLHLVGVPQPEGQCRIEYKQRI

>CYP46 C-term part (Ramy.Naguib)
RLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVP
GNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQME
VKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPTPPPPPC

>CYP51 (Y.Peng) partial
AAAAGMMLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLPAG (0)
KSPPYIFSPIPFLGHAIAFGKSPVEFLENAYEK (0)
VFGKGVAYDVPNP (0)
VFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFQSWGESGEK (1)
VFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSF (2)
RRRDRAHREIKNIFYKAIQKRRQSQEKIDDILQTLLDATYK (0)
DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKT 
VCGENLPPLTYDQ (0)
TVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGE
KFAYVPFGA (1)
GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK