Rhesus monkey P450s (Macaca mulatta)
(in progress, 49 seqs so far)
Jan. 27, 2006
The sequences are shown followed by a blast alignment of the Macaca seq on top compared to the human sequence below. At the bottom of this file a FASTA format collection of the rhesus P450s is given. One surprise finding is that two pseudogenes in humans are not pseudogenes in rhesus monkey. CYP2G2P and CYP1A8P are both full length intact genes.
>CYP1A1
AY635458.1
MLFRISMSATEFLLASLIFCLVFWVIRASRPRVPKGLKNPPGPW
GWPLIGHILTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVQQGDD
FKGRPNLYSFTLISNGQSMSFGPDSGPVWAARRRLAQNGLKSFSIASDPASSSSCYLE
EHVSKEAEVLISKLQEQMAGPGHFNPYRYVVISVANVICAICFGQRYDHNHQELLSLV
NLSNNFGEVVGSGNPADFIPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKG
HIRDITDSLIEHCQEKQLDENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLV
TNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR
DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFITPDGAIDKVLSEKVILF
GLGKRKCIGETIARWEVFLFLAILLQRVEFSVPPGVKVDMTPIYGLTMKHACCEHFQM
QLRS
>CYP1A2
(Aggarwal)
MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDGQSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFPILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDK (0)NSVQDITGALFKHSKKGPRASGNLIPQEKTVNLVNDIFGA (1)GFDTIATAISWSLMYLVTKPEIQRKIQKEL (1)DAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFTIPH (2)STTRDTTLNGFYIPRECCVFINQWQVNHDP (2)QLWGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE FSVPPGVKVDLTPIYGLTMKHARCEHFQAR >CYP1A2 NM_000761 Length = 515 Score = 968 bits (2503), Expect = 0.0 Identities = 472/510 (92%), Positives = 493/510 (96%) Query: 1 MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60 MALSQSVPFSATELLLASAIFCLVFWVL+G RPRVPKGLKSPPEPWGWPLLGHVLTLGKNSbjct: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60 Query: 61 PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG 120 PHLAL+RMSQ YGDVLQIRIGSTPVLVLS LDTIRQALVRQG+DFKGRPDLY+ T ITDGSbjct: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120 Query: 121 QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180 QS++FS DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELMSbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180 Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP 240 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKN+HEFVE+ASS NP+DFFPSbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240 Query: 241 ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDKNSVQDITGALFKHSKKGPRASGN 300 ILRYLPNPALQRFKAFNQRF FLQKTVQEHYQDFDKNSV+DITGALFKHSKKGPRASGNSbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300 Query: 301 LIPQEKTVNLVNDIFGAGFDTIATAISWSLMYLVTKPEIQRKIQKELDAVIGRGRRPRLS 360 LIPQEK VNLVNDIFGAGFDT+ TAISWSLMYLVTKPEIQRKIQKELD VIGR RRPRLSSbjct: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360 Query: 361 DRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTTLNGFYIPRECCVFINQWQVNHDPQL 420 DRPQLPYLEAFILETFRHSSF+PFTIPHSTTRDTTLNGFYIP++CCVF+NQWQVNHDP+LSbjct: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420 Query: 421 WGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE 480 W DPSEFRPERFLTA+GT INKPLSEK+MLFG+GKRRCIGEVL KWE+FLFLAILLQQLESbjct: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480 Query: 481 FSVPPGVKVDLTPIYGLTMKHARCEHFQAR 510 FSVPPGVKVDLTPIYGLTMKHARCEH QARSbjct: 481 FSVPPGVKVDLTPIYGLTMKHARCEHVQAR 510
>CYP1A8P
ortholog possibly a functional
gene in rhesus
MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL
TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL
SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN
GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR
YLPLQIINAPREFYRALNGFIALHVQDHLATYDK
(0)
DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVNDLFGA
(1)
GFETVSTCLYWSFLYLIHYPEIQAKIQEEI
(1)
DGNIGLKPPRFEDRKILPYTEAFISEVFRHASFLPFTIPHC
(2)
TTADTTLNGYFIPRKTCTFINMYQVNHDE
(2)
TIWDNPSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQL
KLKKCPRAKLDLTPTYGLVMRPKPYQLEAERRSSGSSSA
>CYP1A8P
NT_008580.9|Hs9_8737 chromosome 9 Pseudogene 43% to 1A2
Length = 508
Score = 940 bits (2430), Expect = 0.0
Identities = 472/510 (92%), Positives =
486/510 (95%), Gaps = 2/510 (0%)
Query:
1
MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL 60
MIL+LAVTPGEVTTSLIILVMVFVFVRALRSKGRKQ+SPPGP SFPII NLLQLG+HPYL
Sbjct:
1
MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPYL 60
Query:
61
TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL 120
TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVL KDGEHFAGRPNMHTFSFLAEGKSL
Sbjct:
61 TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKSL
120
Query:
121 SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN
180
SFSVNYGESWKLHKKIASKAL T SNAEAKSSTCSC LEEHVTEE+SELVTVFVEL+SKN
Sbjct:
121 SFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSKN
180
Query:
181 GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR 240
G
FDPRNAITC VAN+VCALCFGKR DHSDEEFL+IVKTNDDLLKASSAANPADFIPCL
Sbjct:
181 GSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCLH 240
Query:
241 YLPLQIINAPREFYRALNGFIALHVQDHLATYDKDHIRDITDALINVCHNKYAATKTDTL 300
YLPL+IINAP EFY+ALNGFIALHVQDHLATY KDHIRDITDALINVCHNKYAATKTDTL
Sbjct:
241 YLPLKIINAPLEFYQALNGFIALHVQDHLATYGKDHIRDITDALINVCHNKYAATKTDTL 300
Query:
301 NDSEIISTVNDLFGAGFETVSTCLYWSFLYLIHYPEIQAKIQEEIDGNIGLKPPRFEDRKILPY 360
NDSEIISTV+DLFGAGFETVSTCL WSFLYLIHYPEIQA+IQEEI +PPRFEDRKILPY
Sbjct:
301 NDSEIISTVSDLFGAGFETVSTCLCWSFLYLIHYPEIQARIQEEI------RPPRFEDRKILPY 358
Query:
361 TEAFISEVFRHASFLPFTIPHCTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNPSLF 420
TEAF+SEVFRHASFLPFTIPH TTADTTLNGYFIPRKTCTFINMYQVNHDETIWDN SLF
Sbjct:
359 TEAFVSEVFRHASFLPFTIPHSTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNHSLF 418
Query:
421 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQLKLKKCPRAK 480
RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFIT VLQQ KLKK PRAK
Sbjct:
419 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFKLKK*PRAK 478
Query:
481 LDLTPTYGLVMRPKPYQLEAERRSSGSSSA 510
LDLTPTYGLVMRPK YQL+AE
SGSSSA
Sbjct:
479 LDLTPTYGLVMRPKLYQLQAELHPSGSSSA 508
>CYP1B1
MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI
GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF
ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL
LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA
EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIR
(2)
YPDVQARVQAELDQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTS
VLGYHIPKDTVIFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKR
RCIGEELSKMQLFLFISILAHQCNFRANPNGPEMNFSYGLTIKPKSFKVNVTLRESMELL
DSAVQKLQAEETCQ
>CYP1B1
NM_000104
Length = 543
Score = 1021 bits (2639), Expect = 0.0
Identities = 509/543 (93%), Positives =
519/543 (95%), Gaps = 1/543 (0%)
Query:
1
MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI 60
MGT
LSP DPWPLN LS QQTTLLLLLSVL VHVGQ
LLRQRRRQL S PPGPFAWPLI
Sbjct:
1
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60
Query:
61
GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120
GNAAAVGQA+HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F
Sbjct:
61
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120
Query:
121 ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL 180
ASFRV+SGGRSMAFGHYSEHWKVQRRAAHS MRNF TRQ RSRQVLEGHVLSEARELVAL
Sbjct:
121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180
Query:
181 LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240
LVRGSADGAFLDPR LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
Sbjct:
181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240
Query:
241 VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA 300
VDVMPWLQYFPNP+RT FREFEQLNRNFSNF+LDKFLRHCESLRPGAAPRDMMDAFILSA
Sbjct:
241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA 300
Query:
301 EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIRYPDVQARVQAEL 360
EKKAA
DS
GGARLDLENVPAT+TDIFGASQDTLSTALQWLLLLF RYPDVQ RVQAEL
Sbjct:
301 EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL 360
Query:
361 DQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTSVLGYHIPKDTVI 420
DQVVGRDRLPCM DQPNLPYVLAFLYEAMRFSSFVPVTIPHAT ANTSVLGYHIPKDTV+
Sbjct:
361 DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV 420
Query:
421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480
FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
Sbjct:
421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480
Query:
481 FLFISILAHQCNFRANPNGP-EMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAEE
539
FLFISILAHQC+FRANPN P +MNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQA+E
Sbjct:
481 FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
540
Query:
540 TCQ 542
TCQ
Sbjct:
541 TCQ 543
>CYP2A23 AY635459.1
MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG
NYLQLNTEQMYNSIMKISERYGPVFTIHLGPRRIVVLCGYDAVKEALVDQAEEFSGRG
EQATFDWLFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL
RDTQGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSAGQ
LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNRRTLDPNSPRDFIDSFLIRMQ
EEEKNPNTEFHLKNLVLTSLNLFFGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDQARMPYMEAVIHEIQRFGDMLPLGVAHRVIKDTKFRDFFLPKGTEVF
PMLGSVLKDPKFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF
LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPPNYTMSFLPR
>CYP2A24
AY635460 (Y. Peng)
CYP2A6 best match = CYP2A24 (Y.Peng) partial
MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG
NYLQLNTEQMCNSLMKISERYGPVFTIHLGPRRVVVLCGYDAVKEALVDQAEEFSGRG
EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL
RDTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLGMMLGSFQFTSTSTGQ
LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQHTLDPNSPRDFIDSFLIRMQE
EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVE (1)AKVHEEIDRVIGKNRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPK (0)GTEVFPMLGSVLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSI (1)GKRNCFGEGLARMELFLFFTTIMQNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR Score = 1078 (379.5 bits), Expect = 1.2e-114, P = 1.2e-114 Identities = 204/217 (94%), Positives = 209/217 (96%) Query: 2 EEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGK 61 EEKNPNTEFYLKNL+MTTLNLFI GTETVSTTLRYGFLLLMK+PEVEAKVHEEIDRVIGKSbjct: 1 EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVEAKVHEEIDRVIGK 60 Query: 62 NRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGS 121 NRQPKFEDR KMPYMEAVIHEIQRFGDVIPMSLARRV KDTKFRDFFLPKGTEV+PMLGSSbjct: 61 NRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPKGTEVFPMLGS 120 Query: 122 VLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVM 181 VLRDP FFSNPQDFNPQHFL+EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTT+MSbjct: 121 VLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTIM 180 Query: 182 QNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 218 QNFR KS Q PKDIDVSPKHVGFATIP NYTMSFLPRSbjct: 181 QNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR 217>CYP2C43
AB212264.1
MDSLVVLVLCLSCLLLLSLWRQRSGRGKLPPGPTPLPVIGNILK
IGIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL
FERANRRFGLVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK
ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKFNENAKILSSPWIQIYNN
FSPIIDYFPGTHNKLLKNIAFVKSYILEKVKEHQESMDMNNPRDFIDCFLIKMEKEKH
NQQSEFNIENLENTAVDLFAAGTETTSTTLRYALLLLLKHPEVAAKVQEEIEHVIGRN
RSPCMQDRSRMPYTDAVVHEIQRYIDLLPTSVPHAVTCDVKFRNYLIPKGTTILISLT
SVLRDNKEFPNPEMFDPRHFLDEGGNFKNSNYFMPFSAGKRICVGEALARMELFLFLT
SILQNFNLKSLVDLKDLDTTPVFNGFVSVPPIYQLCFIPV
>CYP2C74 variant (S.Sarva) missing exon 1, 4 aa diffs to 2C74FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGL (1)GIISSNGKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTK (1)ASPCDPTFILGCAPCNVICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQ (0)VCNNFPLLIDCFPGTHNKLLKNVALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQ (0)EKDNQQSEFTIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT (1)AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQRYIDLVPTGVPHAVTTDIKFRNYLIPK (0)GTIIITLLTSVLQDDKEFPNPKIFDPGHFLDENGNFKKSDYFMPFSA (1)GKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGIISLPPSYQICFIPV
>CYP2C8 M17397 Length = 490 Score = 823 bits (2126), Expect = 0.0 Identities = 398/434 (91%), Positives = 413/434 (95%) Frame = +1 Query: 1 FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGLGIISSN 180 FSKVYGPVFTVYFGMNP+VV HGYE VKEALIDN EEFSGRG PIS+RIT GLGIISSNSbjct: 57 FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116 Query: 181 GKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 360 GKRWKE RRFSLT LRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNSbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176 Query: 361 VICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQVCNNFPLLIDCFPGTHNKLLKN 540 VICSVVFQKRFDYKD+NFLTLMKRF NFRIL SPWIQVCNNFPLLIDCFPGTHNK+LKNSbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236 Query: 541 VALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQEKDNQQSEFTIENLVGTVADLFV 720 VALT+SYIR+KVKEHQA+LDVNNPRDF+DCFLIKMEQEKDNQ+SEF IENLVGTVADLFVSbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296 Query: 721 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQ 900 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAV+HEIQSbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356 Query: 901 RYIDLVPTGVPHAVTTDIKFRNYLIPKGTIIITLLTSVLQDDKEFPNPKIFDPGHFLDEN 1080 RY DLVPTGVPHAVTTD KFRNYLIPKGT I+ LLTSVL DDKEFPNP IFDPGHFLD+NSbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416 Query: 1081 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGI 1260 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV DLKNLNTT+ T+GISbjct: 417 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGI 476 Query: 1261 ISLPPSYQICFIPV 1302 +SLPPSYQICFIPVSbjct: 477 VSLPPSYQICFIPV 490
>CYP2C75 AY635463.1
MDSLVVLVLCLSCLLLLSLWRQRSGRGKFPPGPTPLPVIGNILQ
IDIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL
ADRANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK
GSPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLKVMEKLNENVKILSSPWIQICNN
FPPFIDYFPGAHNKLLKNIAFLKSYILEKVKEHQESMDMNNPRDFIDCFLMKMEKEKH
NQQSEFTIENLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN
RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFRNYLIPKGTTILISLT
SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEALARMELFLFLT
SVLQNFNLKSLVDPKDLDTTPVVNGFASVPPFYQLCFIPV
>CYP2C19
best hit (N. Abdeltawab) same as Liao’s hit
below
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTASPCDPTFILGCAPCNVICSV
IFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ (1)
CNNFPALIDYLPGSHNKVVKNFAYVKS
YVLERIKEHQESLDMDNPRDFIDCFLIKMEEKHNLQSEFTIESLIATVTDMFGAGTETTS
TTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLIP
TNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFKKSD
YFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLY
QLCFIPV
>CYP2C18
M61856
Length = 490
Score = 951 bits (2459), Expect = 0.0
Identities = 468/490 (95%), Positives =
481/490 (98%), Gaps = 3/490 (0%)
Query:
1
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV 60
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTN SKV
Sbjct:
1
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
Query:
61
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGE+FSGRGSFPVAEKVNKGLGILFSNGKRW
Sbjct:
61
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120
Query:
121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKT-ASPCDPTFILGCAPCNVICS 179
KEIRRF
LMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct:
121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180
Query:
180 VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ-CNNFPALIDYLPGSHNKVVKNFAYV 238
VIFH+RFDYKDQRFLNLMEKFNENLRILSSPWIQ CNNFPALIDYLPGSHNK+ +NFAY+
Sbjct:
181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240
Query:
239 KSYVLERIKEHQESLDMDNPRDFIDCFLIKME-EKHNLQSEFTIESLIATVTDMFGAGTE 297
KSYVLERIKEHQESLDM++ RDFIDCFLIKME EKHN QSEFT+ESLIATVTDMFGAGTE
Sbjct:
241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300
Query:
298 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 357
TTSTTLR+GLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID
Sbjct:
301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360
Query:
358 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 417
L+PTNLPHAVTCDVKF+NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLD+SGNFK
Sbjct:
361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420
Query:
418 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 477
KSDYFMPFSAGKRMC+GEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP
Sbjct:
421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480
Query:
478 PLYQLCFIPV 487
PLYQLCFIPV
Sbjct:
481 PLYQLCFIPV 490
>searched
with 2C29 differs from 2C43, 2C74, 2C75 (Liao)
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ
(gap in seq, missing one exon)
EKHNLQSEFTIESLIATVTDMFGAG
TETTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRY
IDLIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGN
FKKSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGR
VPPLYQLCFIPV
Length = 490
Score = 679 bits (1753), Expect = 0.0
Identities = 347/490 (70%), Positives =
386/490 (78%), Gaps = 58/490 (11%)
Query:
1
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60
MD V LVLCLSCL
LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV
Sbjct:
1
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
Query:
61
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120
YGPVFT+YFGLKPIVVLHGYEAVKEALID
GE+FSGRG FP+AE+ N+G GI+FSNGK+W
Sbjct:
61
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120
Query:
121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS 180
KEIRRFSLMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS
Sbjct:
121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
Query:
181 VIFH--------------------------------NRF----DY---------KDQRFL 195
+IFH
N F DY K+
F+
Sbjct:
181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240
Query:
196 N--LMEKFNENLRIL--SSPW---------IQVEKHNLQSEFTIESLIATVTDMFGAGTE 242
++EK E+ + ++P ++ EKHN SEFTIESL T D+FGAGTE
Sbjct:
241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
Query:
243 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 302
TTSTTLR+ LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYID
Sbjct:
301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
Query:
303 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 362
L+PT+LPHAVTCD+KFRNYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD GNFK
Sbjct:
361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
Query:
363 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 422
KS
YFMPFSAGKR+CVGE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F VP
Sbjct:
421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480
Query:
423 PLYQLCFIPV 432
P YQLCFIPV
Sbjct:
481 PFYQLCFIPV 490
>CYP2B30
AY635461.1
MELSVLLFLALLTGLLLLLVQRHPNAHGRLPPGPCPLPLLGNLL
QMDRRGLLRSFLRFREKYGDVFTVYLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIA
ITDPVFQGYGVVFANGNRWKVLRRFSLTTMRDFGMGKRSVEERIQEEAQCLIEELRKS
KGALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFE
LLSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEK
SNPHSEFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERIYKEIEQVIGP
HRPPALDDRAKMPYTEAVIHEIQRFADLLPMGVPHIVTQQTSFRGYIIPKDTEVFPLL
STALHDPHYFEKPDTFNPDHFLDANGALKKNEAFIPFSLGRRMCLGEGIARNELFLFF
TTILQNFSVASPVAPEDIDLTPQESGVGKIPPTYQIRFLPR
>CYP2B6 search (M.Puljic) partial
GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS
GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS
EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER
Identities = 162/162 (100%), Positives = 162/162
(100%), Gaps = 0/162 (0%)
Query
1
GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 60
GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS
Sbjct
162
GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 221
Query
61
GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 120
GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS
Sbjct
222
GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 281
Query
121
EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 162
EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER
Sbjct 282
EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 323
>CYP2F6 AY952296.1
MDSISTAILLLLLALVCLLLTLSSRDKXKLPPGPRPLPLLGNLLLLRSQNMLTSLTQ
LSKEYGSVYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPVFFNFTKGN
GIAFSNGDRWKVLRRFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTE
GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTVIRLINDNFQIMSSPWGE
(0)
LYNIFPSLLDWVPGPHQRIFQNFKRLRDLIAHRVHDQQASLDPRSPRDFIDCFLTKMAE
EKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQ
ARVQEEIDLVVGRTRLPTLEDRAAMPYTDAVIHEVQRFADIIPMNLPHRVIRDTAFRXFLIPK
GTDIITLLNTVHYDPSQFLXPQEFNPEHFLDANQSFKKSPAFMPFSA
GRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRSFQLCLCPR
>CYP2D42 (Vasser) also AY635464.1MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ (0)LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQ (1)GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQA (1)GRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLRE (0)VLNAVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK (0)AKGNPESSFNEENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR (1)RVQQEIDNVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIELQGFLIPK (0)GTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA (1)GRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGVFAFLVTPSPYELCAVPR* >CYP2D6 NM_000106Length = 497Score = 940 bits (2430), Expect = 0.0Identities = 465/497 (93%), Positives = 476/497 (95%) Query: 1 MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ 60 M L+ALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDF+NTPYCFDQSbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60 Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQGVF 120 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT GEDTADRPPVPI Q+LG GPRSQGVFSbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120 Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQAGRPFRPNSLLDK 180 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAF + +GRPFRPN LLDKSbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180 Query: 181 AVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLREVLNAVPLLLRIPGLAGKV 240 AVSNVIASLT GRRFEYDDPRFLRL DL E LKEESGFLREVLNAVP+LL IP LAGKVSbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240 Query: 241 LRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNEENLRIVVA 300 LR QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN+ENLRIVVASbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300 Query: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDNVIGQVRRPEMGDQARMPYTTAVI 360 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID+VIGQVRRPEMGDQA MPYTTAVISbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360 Query: 361 HEVQRFGDIVPLGVTHMTSRDIELQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHF 420 HEVQRFGDIVPLG+THMTSRDIE+QGF IPKGTTL TNLSSVLKDEAVWEKPFRFHPEHFSbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420 Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGV 480 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFT LLQ FSFSVP GQPRPSHHGVSbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480 Query: 481 FAFLVTPSPYELCAVPR 497 FAFLV+PSPYELCAVPRSbjct: 481 FAFLVSPSPYELCAVPR 497
>CYP2E1
AY635465.1
MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGN
LFQLELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGD
IPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK
TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFQLLSTPWLQLY
NNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKE
KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG
PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPT
LDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLL
LSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS
>CYP2E1
3 aa diffs, partial (F.Zhang)
MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL
AQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNRP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCSPCNVI
ADILFRKHFDYNDEKFLYNNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPN
CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSITLRYGLLILMKYPE
IE
>CYP2E1 J02843 Length = 493 Score = 576 bits (1484), Expect = e-167 Identities = 283/322 (87%), Positives = 294/322 (91%), Gaps = 20/322 (6%) Frame = -1 Query: 906 MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL 727 &nb