Rhesus monkey P450s (Macaca mulatta)

(in progress, 49 seqs so far)

Jan. 27, 2006

The sequences are shown followed by a blast alignment of the Macaca seq on top compared to the human sequence below. At the bottom of this file a FASTA format collection of the rhesus P450s is given. One surprise finding is that two pseudogenes in humans are not pseudogenes in rhesus monkey. CYP2G2P and CYP1A8P are both full length intact genes.

>CYP1A1 AY635458.1

MLFRISMSATEFLLASLIFCLVFWVIRASRPRVPKGLKNPPGPW

GWPLIGHILTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVQQGDD

FKGRPNLYSFTLISNGQSMSFGPDSGPVWAARRRLAQNGLKSFSIASDPASSSSCYLE

EHVSKEAEVLISKLQEQMAGPGHFNPYRYVVISVANVICAICFGQRYDHNHQELLSLV

NLSNNFGEVVGSGNPADFIPILRYLPNRSLNGFKDLNEKFHSFMQKMIKEHYKTFEKG

HIRDITDSLIEHCQEKQLDENANIQLSDEKIVNVVLDLFGAGFDTVTTAISWSLMYLV

TNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR

DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFITPDGAIDKVLSEKVILF

GLGKRKCIGETIARWEVFLFLAILLQRVEFSVPPGVKVDMTPIYGLTMKHACCEHFQM

QLRS

>CYP1A2 (Aggarwal)

MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG
QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP
ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDK (0)
NSVQDITGALFKHSKKGPRASGNLIPQEKTVNLVNDIFGA (1)
GFDTIATAISWSLMYLVTKPEIQRKIQKEL (1)
DAVIGRGRRPRLSDRPQLPYLEAFILETFRHSSFVPFTIPH (2)
STTRDTTLNGFYIPRECCVFINQWQVNHDP (2)
QLWGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE FSVPPGVKVDLTPIYGLTMKHARCEHFQAR
 
>CYP1A2 NM_000761
 Length = 515
 
 Score = 968 bits (2503), Expect = 0.0
 Identities = 472/510 (92%), Positives = 493/510 (96%)
 
Query: 1 MALSQSVPFSATELLLASAIFCLVFWVLRGSRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
 MALSQSVPFSATELLLASAIFCLVFWVL+G RPRVPKGLKSPPEPWGWPLLGHVLTLGKN
Sbjct: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
 
Query: 61 PHLALARMSQLYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGNDFKGRPDLYSFTFITDG 120
 PHLAL+RMSQ YGDVLQIRIGSTPVLVLS LDTIRQALVRQG+DFKGRPDLY+ T ITDG
Sbjct: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120
 
Query: 121 QSMSFSPDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180
 QS++FS DSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM
Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180
 
Query: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNSHEFVESASSANPVDFFP 240
 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKN+HEFVE+ASS NP+DFFP
Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240
 
Query: 241 ILRYLPNPALQRFKAFNQRFRRFLQKTVQEHYQDFDKNSVQDITGALFKHSKKGPRASGN 300
 ILRYLPNPALQRFKAFNQRF FLQKTVQEHYQDFDKNSV+DITGALFKHSKKGPRASGN
Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN 300
 
Query: 301 LIPQEKTVNLVNDIFGAGFDTIATAISWSLMYLVTKPEIQRKIQKELDAVIGRGRRPRLS 360
 LIPQEK VNLVNDIFGAGFDT+ TAISWSLMYLVTKPEIQRKIQKELD VIGR RRPRLS
Sbjct: 301 LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS 360
 
Query: 361 DRPQLPYLEAFILETFRHSSFVPFTIPHSTTRDTTLNGFYIPRECCVFINQWQVNHDPQL 420
 DRPQLPYLEAFILETFRHSSF+PFTIPHSTTRDTTLNGFYIP++CCVF+NQWQVNHDP+L
Sbjct: 361 DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL 420
 
Query: 421 WGDPSEFRPERFLTAEGTTINKPLSEKIMLFGLGKRRCIGEVLGKWEVFLFLAILLQQLE 480
 W DPSEFRPERFLTA+GT INKPLSEK+MLFG+GKRRCIGEVL KWE+FLFLAILLQQLE
Sbjct: 421 WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE 480
 
Query: 481 FSVPPGVKVDLTPIYGLTMKHARCEHFQAR 510
  FSVPPGVKVDLTPIYGLTMKHARCEH QAR
Sbjct: 481 FSVPPGVKVDLTPIYGLTMKHARCEHVQAR 510

>CYP1A8P ortholog possibly a functional gene in rhesus

MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL

TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL

SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN

GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR

YLPLQIINAPREFYRALNGFIALHVQDHLATYDK (0)

DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVNDLFGA (1)

GFETVSTCLYWSFLYLIHYPEIQAKIQEEI (1)

DGNIGLKPPRFEDRKILPYTEAFISEVFRHASFLPFTIPHC (2)

TTADTTLNGYFIPRKTCTFINMYQVNHDE (2)

TIWDNPSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQL

KLKKCPRAKLDLTPTYGLVMRPKPYQLEAERRSSGSSSA

>CYP1A8P NT_008580.9|Hs9_8737 chromosome 9 Pseudogene 43% to 1A2

Length = 508

Score = 940 bits (2430), Expect = 0.0

Identities = 472/510 (92%), Positives = 486/510 (95%), Gaps = 2/510 (0%)

Query: 1 MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL 60

MIL+LAVTPGEVTTSLIILVMVFVFVRALRSKGRKQ+SPPGP SFPII NLLQLG+HPYL

Sbjct: 1 MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPYL 60

Query: 61 TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL 120

TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVL KDGEHFAGRPNMHTFSFLAEGKSL

Sbjct: 61 TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKSL 120

Query: 121 SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN 180

SFSVNYGESWKLHKKIASKAL T SNAEAKSSTCSC LEEHVTEE+SELVTVFVEL+SKN

Sbjct: 121 SFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSKN 180

Query: 181 GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR 240

G FDPRNAITC VAN+VCALCFGKR DHSDEEFL+IVKTNDDLLKASSAANPADFIPCL

Sbjct: 181 GSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCLH 240

Query: 241 YLPLQIINAPREFYRALNGFIALHVQDHLATYDKDHIRDITDALINVCHNKYAATKTDTL 300

YLPL+IINAP EFY+ALNGFIALHVQDHLATY KDHIRDITDALINVCHNKYAATKTDTL

Sbjct: 241 YLPLKIINAPLEFYQALNGFIALHVQDHLATYGKDHIRDITDALINVCHNKYAATKTDTL 300

Query: 301 NDSEIISTVNDLFGAGFETVSTCLYWSFLYLIHYPEIQAKIQEEIDGNIGLKPPRFEDRKILPY 360

NDSEIISTV+DLFGAGFETVSTCL WSFLYLIHYPEIQA+IQEEI +PPRFEDRKILPY

Sbjct: 301 NDSEIISTVSDLFGAGFETVSTCLCWSFLYLIHYPEIQARIQEEI------RPPRFEDRKILPY 358

Query: 361 TEAFISEVFRHASFLPFTIPHCTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNPSLF 420

TEAF+SEVFRHASFLPFTIPH TTADTTLNGYFIPRKTCTFINMYQVNHDETIWDN SLF

Sbjct: 359 TEAFVSEVFRHASFLPFTIPHSTTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNHSLF 418

Query: 421 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQLKLKKCPRAK 480

RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFIT VLQQ KLKK PRAK

Sbjct: 419 RPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFKLKK*PRAK 478

Query: 481 LDLTPTYGLVMRPKPYQLEAERRSSGSSSA 510

LDLTPTYGLVMRPK YQL+AE SGSSSA

Sbjct: 479 LDLTPTYGLVMRPKLYQLQAELHPSGSSSA 508

>CYP1B1

MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI

GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF

ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL

LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA

EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIR (2)

YPDVQARVQAELDQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTS

VLGYHIPKDTVIFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKR

RCIGEELSKMQLFLFISILAHQCNFRANPNGPEMNFSYGLTIKPKSFKVNVTLRESMELL

DSAVQKLQAEETCQ

>CYP1B1 NM_000104

Length = 543

Score = 1021 bits (2639), Expect = 0.0

Identities = 509/543 (93%), Positives = 519/543 (95%), Gaps = 1/543 (0%)

Query: 1 MGTGLSPKDPWPLNLLSTQQTTLLLLLSVLVAVHVGQWLLRQRRRQLGSTPPGPFAWPLI 60

MGT LSP DPWPLN LS QQTTLLLLLSVL VHVGQ LLRQRRRQL S PPGPFAWPLI

Sbjct: 1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

Query: 61 GNAAAVGQASHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120

GNAAAVGQA+HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F

Sbjct: 61 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

Query: 121 ASFRVISGGRSMAFGHYSEHWKVQRRAAHSTMRNFSTRQLRSRQVLEGHVLSEARELVAL 180

ASFRV+SGGRSMAFGHYSEHWKVQRRAAHS MRNF TRQ RSRQVLEGHVLSEARELVAL

Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

Query: 181 LVRGSADGAFLDPRQLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

LVRGSADGAFLDPR LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

Query: 241 VDVMPWLQYFPNPMRTAFREFEQLNRNFSNFVLDKFLRHCESLRPGAAPRDMMDAFILSA 300

VDVMPWLQYFPNP+RT FREFEQLNRNFSNF+LDKFLRHCESLRPGAAPRDMMDAFILSA

Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA 300

Query: 301 EKKAARDSDDGGARLDLENVPATVTDIFGASQDTLSTALQWLLLLFIRYPDVQARVQAEL 360

EKKAA DS GGARLDLENVPAT+TDIFGASQDTLSTALQWLLLLF RYPDVQ RVQAEL

Sbjct: 301 EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL 360

Query: 361 DQVVGRDRLPCMDDQPNLPYVLAFLYEAMRFSSFVPVTIPHATNANTSVLGYHIPKDTVI 420

DQVVGRDRLPCM DQPNLPYVLAFLYEAMRFSSFVPVTIPHAT ANTSVLGYHIPKDTV+

Sbjct: 361 DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV 420

Query: 421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480

FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL

Sbjct: 421 FVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480

Query: 481 FLFISILAHQCNFRANPNGP-EMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAEE 539

FLFISILAHQC+FRANPN P +MNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQA+E

Sbjct: 481 FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE 540

Query: 540 TCQ 542

TCQ

Sbjct: 541 TCQ 543

>CYP2A23 AY635459.1

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMYNSIMKISERYGPVFTIHLGPRRIVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWLFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTQGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSAGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNRRTLDPNSPRDFIDSFLIRMQ

EEEKNPNTEFHLKNLVLTSLNLFFGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV

IGKNRQPKFEDQARMPYMEAVIHEIQRFGDMLPLGVAHRVIKDTKFRDFFLPKGTEVF

PMLGSVLKDPKFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF

LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPPNYTMSFLPR

>CYP2A24 AY635460 (Y. Peng)

CYP2A6 best match = CYP2A24 (Y.Peng) partial 

MLASGLLLVALLACLTVMVLMSVWQQRNSKGKLPPGPTPLPFIG

NYLQLNTEQMCNSLMKISERYGPVFTIHLGPRRVVVLCGYDAVKEALVDQAEEFSGRG

EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIEAL

RDTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLGMMLGSFQFTSTSTGQ

LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQHTLDPNSPRDFIDSFLIRMQE

EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVE (1)
AKVHEEIDRVIGKNRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPK (0)
GTEVFPMLGSVLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSI (1)
GKRNCFGEGLARMELFLFFTTIMQNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR
 
Score = 1078 (379.5 bits), Expect = 1.2e-114, P = 1.2e-114
 Identities = 204/217 (94%), Positives = 209/217 (96%)
 
Query: 2 EEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGK 61
 EEKNPNTEFYLKNL+MTTLNLFI GTETVSTTLRYGFLLLMK+PEVEAKVHEEIDRVIGK
Sbjct: 1 EEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLRYGFLLLMKYPEVEAKVHEEIDRVIGK 60
 
Query: 62 NRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGS 121
 NRQPKFEDR KMPYMEAVIHEIQRFGDVIPMSLARRV KDTKFRDFFLPKGTEV+PMLGS
Sbjct: 61 NRQPKFEDRVKMPYMEAVIHEIQRFGDVIPMSLARRVNKDTKFRDFFLPKGTEVFPMLGS 120
 
Query: 122 VLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVM 181
 VLRDP FFSNPQDFNPQHFL+EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTT+M
Sbjct: 121 VLRDPRFFSNPQDFNPQHFLDEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTIM 180
 
Query: 182 QNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR 218
 QNFR KS Q PKDIDVSPKHVGFATIP NYTMSFLPR
Sbjct: 181 QNFRFKSPQLPKDIDVSPKHVGFATIPPNYTMSFLPR 217
 

>CYP2C43 AB212264.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKLPPGPTPLPVIGNILK

IGIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

FERANRRFGLVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKFNENAKILSSPWIQIYNN

FSPIIDYFPGTHNKLLKNIAFVKSYILEKVKEHQESMDMNNPRDFIDCFLIKMEKEKH

NQQSEFNIENLENTAVDLFAAGTETTSTTLRYALLLLLKHPEVAAKVQEEIEHVIGRN

RSPCMQDRSRMPYTDAVVHEIQRYIDLLPTSVPHAVTCDVKFRNYLIPKGTTILISLT

SVLRDNKEFPNPEMFDPRHFLDEGGNFKNSNYFMPFSAGKRICVGEALARMELFLFLT

SILQNFNLKSLVDLKDLDTTPVFNGFVSVPPIYQLCFIPV

>CYP2C74 variant (S.Sarva) missing exon 1, 4 aa diffs to 2C74
FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGL (1)
GIISSNGKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTK (1)
ASPCDPTFILGCAPCNVICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQ (0)
VCNNFPLLIDCFPGTHNKLLKNVALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQ (0)
EKDNQQSEFTIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVT (1)
AKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQRYIDLVPTGVPHAVTTDIKFRNYLIPK (0)
GTIIITLLTSVLQDDKEFPNPKIFDPGHFLDENGNFKKSDYFMPFSA (1)
GKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGIISLPPSYQICFIPV

>CYP2C8 M17397
 Length = 490
 
 Score = 823 bits (2126), Expect = 0.0
 Identities = 398/434 (91%), Positives = 413/434 (95%)
 Frame = +1
 
Query: 1 FSKVYGPVFTVYFGMNPVVVLHGYETVKEALIDNAEEFSGRGILPISERITNGLGIISSN 180
 FSKVYGPVFTVYFGMNP+VV HGYE VKEALIDN EEFSGRG PIS+RIT GLGIISSN
Sbjct: 57 FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116
 
Query: 181 GKRWKETRRFSLTTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 360
 GKRWKE RRFSLT LRNFGMGKRSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCN
Sbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176
 
Query: 361 VICSVVFQKRFDYKDENFLTLMKRFTVNFRILTSPWIQVCNNFPLLIDCFPGTHNKLLKN 540
 VICSVVFQKRFDYKD+NFLTLMKRF NFRIL SPWIQVCNNFPLLIDCFPGTHNK+LKN
Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236
 
Query: 541 VALTKSYIRKKVKEHQATLDVNNPRDFIDCFLIKMEQEKDNQQSEFTIENLVGTVADLFV 720
 VALT+SYIR+KVKEHQA+LDVNNPRDF+DCFLIKMEQEKDNQ+SEF IENLVGTVADLFV
Sbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296
 
Query: 721 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVIHEIQ 900
 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAV+HEIQ
Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356
 
Query: 901 RYIDLVPTGVPHAVTTDIKFRNYLIPKGTIIITLLTSVLQDDKEFPNPKIFDPGHFLDEN 1080
 RY DLVPTGVPHAVTTD KFRNYLIPKGT I+ LLTSVL DDKEFPNP IFDPGHFLD+N
Sbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416
 
Query: 1081 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVADLKNLNTTSATRGI 1260
 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV DLKNLNTT+ T+GI
Sbjct: 417 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGI 476
 
Query: 1261 ISLPPSYQICFIPV 1302
 +SLPPSYQICFIPV
Sbjct: 477 VSLPPSYQICFIPV 490
 

>CYP2C75 AY635463.1

MDSLVVLVLCLSCLLLLSLWRQRSGRGKFPPGPTPLPVIGNILQ

IDIKDVSKSLTNLSKVYGPVFTLYFGLERMVVLHGYEAVKEALIDLGEEFSGRGHFPL

ADRANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK

GSPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLKVMEKLNENVKILSSPWIQICNN

FPPFIDYFPGAHNKLLKNIAFLKSYILEKVKEHQESMDMNNPRDFIDCFLMKMEKEKH

NQQSEFTIENLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN

RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFRNYLIPKGTTILISLT

SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEALARMELFLFLT

SVLQNFNLKSLVDPKDLDTTPVVNGFASVPPFYQLCFIPV

>CYP2C19 best hit (N. Abdeltawab) same as Liao’s hit below

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTASPCDPTFILGCAPCNVICSV
IFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ (1)

CNNFPALIDYLPGSHNKVVKNFAYVKS
YVLERIKEHQESLDMDNPRDFIDCFLIKMEEKHNLQSEFTIESLIATVTDMFGAGTETTS
TTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLIP
TNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFKKSD
YFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLY
QLCFIPV

>CYP2C18 M61856

Length = 490

Score = 951 bits (2459), Expect = 0.0

Identities = 468/490 (95%), Positives = 481/490 (98%), Gaps = 3/490 (0%)

Query: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNVSKV 60

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTN SKV

Sbjct: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

Query: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120

YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGE+FSGRGSFPVAEKVNKGLGILFSNGKRW

Sbjct: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKT-ASPCDPTFILGCAPCNVICS 179

KEIRRF LMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICS 180

Query: 180 VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ-CNNFPALIDYLPGSHNKVVKNFAYV 238

VIFH+RFDYKDQRFLNLMEKFNENLRILSSPWIQ CNNFPALIDYLPGSHNK+ +NFAY+

Sbjct: 181 VIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYI 240

Query: 239 KSYVLERIKEHQESLDMDNPRDFIDCFLIKME-EKHNLQSEFTIESLIATVTDMFGAGTE 297

KSYVLERIKEHQESLDM++ RDFIDCFLIKME EKHN QSEFT+ESLIATVTDMFGAGTE

Sbjct: 241 KSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTE 300

Query: 298 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 357

TTSTTLR+GLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID

Sbjct: 301 TTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 360

Query: 358 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 417

L+PTNLPHAVTCDVKF+NYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLD+SGNFK

Sbjct: 361 LLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFK 420

Query: 418 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 477

KSDYFMPFSAGKRMC+GEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP

Sbjct: 421 KSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 480

Query: 478 PLYQLCFIPV 487

PLYQLCFIPV

Sbjct: 481 PLYQLCFIPV 490

>searched with 2C29 differs from 2C43, 2C74, 2C75 (Liao)

MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV
YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS
VIFHNRFDYKDQRFLNLMEKFNENLRILSSPWIQ

(gap in seq, missing one exon)

EKHNLQSEFTIESLIATVTDMFGAG
TETTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRY
IDLIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGN
FKKSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGR
VPPLYQLCFIPV

>CYP2C9 M61857

Length = 490

Score = 679 bits (1753), Expect = 0.0

Identities = 347/490 (70%), Positives = 386/490 (78%), Gaps = 58/490 (11%)

Query: 1 MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKV 60

MD V LVLCLSCL LLSLWRQSSGRG+LP GPTPLP+IGNILQ+ +KD+SKSLTN SKV

Sbjct: 1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61 YGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEKFSGRGSFPVAEKVNKGLGILFSNGKRW 120

YGPVFT+YFGLKPIVVLHGYEAVKEALID GE+FSGRG FP+AE+ N+G GI+FSNGK+W

Sbjct: 61 YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEALCLVEELRKTNASPCDPTFILGCAPCNVICS 180

KEIRRFSLMTLRNFGMGKRSIEDRVQEEA CLVEELRKT ASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 181 VIFH--------------------------------NRF----DY---------KDQRFL 195

+IFH N F DY K+ F+

Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 196 N--LMEKFNENLRIL--SSPW---------IQVEKHNLQSEFTIESLIATVTDMFGAGTE 242

++EK E+ + ++P ++ EKHN SEFTIESL T D+FGAGTE

Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 243 TTSTTLRFGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYID 302

TTSTTLR+ LLLLLK+PEVTAKVQEEIE V+GRNRSPCMQDRSHMPYTDAVVHE+QRYID

Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 303 LIPTNLPHAVTCDVKFRNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDRSGNFK 362

L+PT+LPHAVTCD+KFRNYLIPKGTTI+ SLTSVLH++KEFPNPEMFDP HFLD GNFK

Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 363 KSDYFMPFSAGKRMCVGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVP 422

KS YFMPFSAGKR+CVGE LA MELFLFLT+ILQNFNLKS VDPK++D TP+ N F VP

Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 423 PLYQLCFIPV 432

P YQLCFIPV

Sbjct: 481 PFYQLCFIPV 490

>CYP2B30 AY635461.1

MELSVLLFLALLTGLLLLLVQRHPNAHGRLPPGPCPLPLLGNLL

QMDRRGLLRSFLRFREKYGDVFTVYLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIA

ITDPVFQGYGVVFANGNRWKVLRRFSLTTMRDFGMGKRSVEERIQEEAQCLIEELRKS

KGALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFE

LLSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEK

SNPHSEFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERIYKEIEQVIGP

HRPPALDDRAKMPYTEAVIHEIQRFADLLPMGVPHIVTQQTSFRGYIIPKDTEVFPLL

STALHDPHYFEKPDTFNPDHFLDANGALKKNEAFIPFSLGRRMCLGEGIARNELFLFF

TTILQNFSVASPVAPEDIDLTPQESGVGKIPPTYQIRFLPR

>CYP2B6 search (M.Puljic) partial

GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS

GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS

EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER

Identities = 162/162 (100%), Positives = 162/162 (100%), Gaps = 0/162 (0%)

Query 1 GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 60

GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS

Sbjct 162 GALVDPTFLFHSITANIICSIVFGKRFHYQDQEFLKILNLFYHTFSLASSMFGQLFELLS 221

Query 61 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 120

GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS

Sbjct 222 GFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPQDLIDSYLLQMEKEKSNPHS 281

Query 121 EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 162

EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER

Sbjct 282 EFSHRNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVAER 323

>CYP2F6 AY952296.1

MDSISTAILLLLLALVCLLLTLSSRDKXKLPPGPRPLPLLGNLLLLRSQNMLTSLTQ

LSKEYGSVYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPVFFNFTKGN

GIAFSNGDRWKVLRRFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTE

GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTVIRLINDNFQIMSSPWGE (0)

LYNIFPSLLDWVPGPHQRIFQNFKRLRDLIAHRVHDQQASLDPRSPRDFIDCFLTKMAE

EKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQ

ARVQEEIDLVVGRTRLPTLEDRAAMPYTDAVIHEVQRFADIIPMNLPHRVIRDTAFRXFLIPK

GTDIITLLNTVHYDPSQFLXPQEFNPEHFLDANQSFKKSPAFMPFSA

GRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRSFQLCLCPR

>CYP2D42 (Vasser) also AY635464.1
MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ (0)
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQ (1)
GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQA (1)
GRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLRE (0)
VLNAVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK (0)
AKGNPESSFNEENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR (1)
RVQQEIDNVIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIELQGFLIPK (0)
GTTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSA (1)
GRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGVFAFLVTPSPYELCAVPR*
 
>CYP2D6 NM_000106
Length = 497
Score = 940 bits (2430), Expect = 0.0
Identities = 465/497 (93%), Positives = 476/497 (95%)
 
Query: 1 MELDALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ 60
 M L+ALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDF+NTPYCFDQ
Sbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60
 
Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGVGPRSQGVF 120
 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT GEDTADRPPVPI Q+LG GPRSQGVF
Sbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
 
Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQAGRPFRPNSLLDK 180
 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAF + +GRPFRPN LLDK
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
 
Query: 181 AVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLREVLNAVPLLLRIPGLAGKV 240
 AVSNVIASLT GRRFEYDDPRFLRL DL E LKEESGFLREVLNAVP+LL IP LAGKV
Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
 
Query: 241 LRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNEENLRIVVA 300
 LR QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFN+ENLRIVVA
Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300
 
Query: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDNVIGQVRRPEMGDQARMPYTTAVI 360
 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID+VIGQVRRPEMGDQA MPYTTAVI
Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
 
Query: 361 HEVQRFGDIVPLGVTHMTSRDIELQGFLIPKGTTLFTNLSSVLKDEAVWEKPFRFHPEHF 420
 HEVQRFGDIVPLG+THMTSRDIE+QGF IPKGTTL TNLSSVLKDEAVWEKPFRFHPEHF
Sbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
 
Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSHHGV 480
 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFT LLQ FSFSVP GQPRPSHHGV
Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
 
Query: 481 FAFLVTPSPYELCAVPR 497
 FAFLV+PSPYELCAVPR
Sbjct: 481 FAFLVSPSPYELCAVPR 497

>CYP2E1 AY635465.1

MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGN

LFQLELKNIPKSFTRLAQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGD

IPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK

TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFQLLSTPWLQLY

NNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPNCPRDLTDCLLVEMEKE

KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG

PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYIIPKGTVIVPT

LDSVLYDNQEFPDPEKFKPEHFLDESGKFKYSDYFKPFSAGKRVCAGEGLARMELFLL

LSAILQHFNLKPLVDPKDIDISPVNIGFGCIPPRFKLCVIPRS

>CYP2E1 3 aa diffs, partial (F.Zhang)

MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL
AQRFGPVFTLYVGSRRVVVVHGYKAVREVLLDHKDEFSGRGDIPAFHAHRDRGIIFNNRP
TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCSPCNVI
ADILFRKHFDYNDEKFLYNNFPSLLHYLPGSHRKVMKNVAEIKEYVSERVKEHLQSLDPN
CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSITLRYGLLILMKYPE
IE

>CYP2E1 J02843
  Length = 493
 
 Score = 576 bits (1484), Expect = e-167
 Identities = 283/322 (87%), Positives = 294/322 (91%), Gaps = 20/322 (6%)
 Frame = -1
 
Query: 906 MSALGVSVALLVWVAVLLLVSIWRQVHSSWNLPPGPFPLPIIGNLFQLEWKNIPKSFTRL 727
  &nb