44 Drosophila mitochondrial carriers
.
23 S. pombe mitochondrial carriers
S. pombe is carrier deficient compared to Bakers yeast. S. pombe seems to
be missing the succinate fumarate carrier SFC1, the dicarboxylate carrier DIC1
The carnitine acylcarnitine carrier CRC1 and 6 other yeast carriers
YPR011c, YPR021c, YPR128c, YFR045w, YDR470c, and YGR096w.
S. pombe has three carriers that do not have clear orthologs in yeast
AL133157, AL034433 and Z56276.
33 Dictyostelium mitochondrial carriers
This is a work in progress. Many of these carriers are not completely
assembled. There are long runs of mono polymer like QQQQQQQQ or NNNNNNNN.
These seem to be in places where they ought to be removed.
35 yeast mitochondrial carriers
33 Candida albicans mitochondrial carriers
Yeast mitochondrial carriers, (5k) are listed
here
with their chromosome assignment,
length and gene name.
.
33 C. elegans mitochondrial carriers
.
Other mitochondrial carriers, (5k) are listed here,
with accession numbers and a brief note concerning any known functions they have.
.
an alignment of the sequences and a list of GenBank accession numbers.
There are 35 of these carriers known in S. cerevisiae, 33 in Candida albicans, 47 carriers in humans, (with many pseudogenes) 44 in Drosophila and 33 in C. elegans Updated 10/31/2000
.
An Alignment of 263 mitochondrial carriers,(101k) 10/16/2000
Some of these are Expressed Sequence Tags (ESTs) and they contain many frame
shifts. It is not always possible to follow these shifts, so the EST sequences are
approximate. The Emericella nidulans sequence has a frameshift at the end, so the C-terminal is not correct in the original. There are now 47 human carriers in this
alignment, 44 Drosophila carriers, 33 C. elegans and 25 mouse carriers.
.
An Alignment of 44 Drosophila mitochondrial carriers,(20k)
.
An Alignment of 47 human mitochondrial carriers,(21k)
.
An Alignment of 47 human mitochondrial carriers, with introns marked(21k) not finished yet
.
An map of intron position in 47 carriers(21k) not finished yet
This is the sequence alignment above with all amino acids changed to dashes. It is much easier to see the intron markers this way. 0= phase 0 intron between Codons. 1 = phase 1 (intron after first nucleotide), 2 = phase 2 (intron after second nucleotide) .
An Alignment of 33 C. elegans mitochondrial carriers,(15k)
.
An Alignment of 35 yeast mitochondrial carriers,(16k)
.
An Alignment of 35 yeast mitochondrial carriers and 32 Dictyostelium carriers
NEW .
These alignments are modular and can be combined in a word processor
by pasting the pages together. The alignment positions are the same in
each file. This way all six pairwise species combinations can be made.
The following six PDF files contain phylogenetic trees of all carrier
sequences from human, yeast(except YDR470c), C. elegans and Drosophila.
The sequence numbers refer to the alignment of 263 carriers.
The same numbers are used in the four species alignments above.
A phylogenetic tree of 34 yeast mitochondrial
carriers, and 47 human carriers [PDF}
.
A phylogenetic tree of 34 yeast mitochondrial carriers, and 33 C. elegans carriers [PDF}
.
A phylogenetic tree of 33 C. elegans mitochondrial carriers, and 47 human carriers [PDF}
as an experiment, this tree is drawn backwards for easy comparison to other trees.
A phylogenetic tree of 44 Drosophila mitochondrial
carriers, and 47 human carriers [PDF}
.
A phylogenetic tree of 44 Drosophila mitochondrial carriers, and 33 C. elegans carriers [PDF}
.
A phylogenetic tree of 44 Drosophila mitochondrial carriers, and 34 yeast carriers [PDF}
.
A new UCP3 gene in humans Also noted here is a problem with mouse contamination of a Stratagene human fibroblast library. .
A link to David Nelson's Homepage
.