Human Cytochrome P450s

Note on Jan. 24, 2007 I have completed a total revision of this page.

On May 17, I added links to the Human Gene Nomenclature Committee names (HGNC).

Last revised May 17, 2007

I have tried to make this table as up to date as possible. Entrez Gene, OMIM, Unigene and all other links have been checked and updated.

I have included seven gene cluster maps that show human, mouse and rat compared (red links in the first column).

These maps are further described in:

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes

Pharmacogenetics 14, 1-18 2004

The Entrez Gene site has extensive data and links for intact sequences and some pseudogenes.

For a complete set of human P450 sequences including pseudogenes go to the FASTA file

All human P450 genes and all P450 pseudogenes are included in this table.

This table contains more than 700 links to human P450 data, including known crystal structures.

CYP names in column 1 are linked to their protein sequences, including the pseudogenes.

X at the end of a CYP name means that name has been discontinued and replaced by a new name

Pseudogenes are named using suffixes to specify the four types of pseudogenes defined as:

P is a full length or near full length pseudogene, it may be near or far from other P450s.

-ps is equivalent to P, but it is required nomenclature for mouse full length pseudogenes.

-de stands for detritus exons (found near other full length genes).

-se stands for solo exons, one or a few exons found distant from a P450 gene.

-ie stands for internal exons, duplicate exons found inside some P450 genes.

CYP	Genbank	RefSeq mRNA	Genomic Assemblies	RefSeq Protein	OMIM	HGNC	Unigene	EntrezGene	comments
1A1	see related sequences under the Entrez Gene link	NM_000499	see reference assembly under the Entrez Gene link	NP_000490	108330	2595	Hs.72912 (70 ESTs)	CYP1A1	15q24.1
1A2	see related sequences under the Entrez Gene link	NM_000761	see reference assembly under the Entrez Gene link	NP_000752	124060	2596	Hs.1361 (26 ESTs)	CYP1A2	15q24.1
1D1P/1A8P	AL359997.8	no entry	NT_023935.17	no entry	no entry	hold	no entry	no entry	9q21.12 43% identical to 1A2, ortholog to Danio 1D1
1B1	see related sequences under the Entrez Gene link	NM_000104	see reference assembly under the Entrez Gene link	NP_000095	601771 see additional entries under phenotypes in the Entrez Gene link	2597	Hs.154654 (584 ESTs)	CYP1B1	2p22.2
2A 2ABFGST gene cluster map	see related sequences under the Entrez Gene link	no entry	NG_000008	no entry	123960	2607	no entry	CYP2ABFGST cluster	19q13.2
2A6	see related sequences under the Entrez Gene link	NM_000762	see reference assembly under the Entrez Gene link	NP_000753	122720	2610	Hs.439056 (217 ESTs)	CYP2A6	19q13.2 Structures 2FDY 2FDW 2FDV 2FDU 1Z11 1Z10
2A6v2	U22027	no entry	no entry	no entry	122720	hold	no entry	CYP2A6	*2A63 allele**
2A7v1	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	608054	2611	Hs.250615 (34 ESTs)	CYP2A7	19q13.2 wt seq
2A7v2	U22029	NM_000764	see related sequences under the Entrez Gene link	NP_000755	608054	hold	Hs.250615 (34 ESTs)	CYP2A7	19q13.2 hybrid, exon 8 from 2A18PC
2A7_v1axΔ2a	NM_030589	NM_030589	see reference assembly under the Entrez Gene link	NP_085079.2	no entry	hold	Hs.250615 (34 ESTs)	CYP2A7	19q13.2 alt. splice, exon 2 deleted
2A7PTX	U22030	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2612	Hs.250615 (34 ESTs)	2A7 pseudogene N-term.	identical to 2A18PN
2A7PCX	U22044	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2612	Hs.250615 (34 ESTs)	2A7 pseudogene N-term.	identical to 2A18PN
2A13	see related sequences under the Entrez Gene link	NM_000766	see reference assembly under the Entrez Gene link	NP_000757	no entry	2608	Hs.181973 (1 EST)	CYP2A13	19q13.2
2A18PC	AC008537.5	no entry	NT_011109.15	no entry	no entry	2612	no entry	no entry	opposite end of 2A18PN
2A18PN	AC008537.5	no entry	NT_011109.15	no entry	no entry	hold	Hs.250615 (34 ESTs)	2A7 pseudogene N-term.	formerly 2A7PT and 2A7PC
2B	no entry	no entry	NT_011109.15	no entry	123930	2614	no entry	CYP2B subfamily	19q13.2
2B6	see related sequences under the Entrez Gene link	NM_000767	see reference assembly under the Entrez Gene link	NP_000758	123930	2615	Hs.1360 (38 ESTs)	CYP2B6	19q13.2
2B7P1	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2616	Hs.529117 (62 ESTs)	CYP2B71P	HIIB3
2B7P2X	AC011541.7	no entry	NT_011109.15	no entry	no entry	hold	no entry	no entry	exon 1 only, error = 2B6
2B7P3X	AC008539.6	no entry	NT_011109.15	no entry	no entry	hold	no entry	no entry	exon 1 only, error = 2B6
2C8 2C gene cluster map	see related sequences under the Entrez Gene link	NM_000770	see reference assembly under the Entrez Gene link	NP_000761	601129	2622	Hs.282871 (188 ESTs)	CYP2C8	10q23.33 Structures 1PQ2
2C8-de6b	AL359672.19	no entry	NT_030059.12	no entry	no entry	hold	no entry	no entry	detritus exon 6 near 2C8
2C9	see related sequences under the Entrez Gene link	NM_000771	see reference assembly under the Entrez Gene link	NP_000762	601130	2623	Hs.282624 (182 ESTs)	CYP2C9	10q23.33 Structures 1R9O 1OG5 1OG2
2C9-de1b	AL359672.19	no entry	NT_030059.12	no entry	no entry	hold	no entry	no entry	detritus exon 1 near 2C9
2C9-de2c3c	AL359672.19	no entry	NT_030059.12	no entry	no entry	hold	no entry	no entry	detritus exons 2,3 near 2C9
2C18	see related sequences under the Entrez Gene link	NM_000772	see reference assembly under the Entrez Gene link	NP_000763	601131	2620	Hs.511872 (38 ESTs)	CYP2C18	10q23.33
2C19	see related sequences under the Entrez Gene link	NM_000769	see reference assembly under the Entrez Gene link	NP_000760	124020	2621	Hs.282409 (10 ESTs)	CYP2C19	10q23.33
2C58P	AL133513.12	no entry	NT_030059.12	no entry	no entry	hold	no entry	no entry	solo exons 1,2,3 between 2C19 and 2C9
2C62P	AL138921.14	no entry	NT_030059.12	no entry	no entry	hold	no entry	no entry	10q24.31 pseudogene 5Mb upstream of 2C8
2C-se1[7]	AC110078.2	no entry	NT_005403.16	no entry	no entry	hold	no entry	no entry	solo exon 7, 2q24.3 = old CYP2C56P
2C-se2[1:2]	AC069020.8	no entry	NT_008583.16	no entry	no entry	hold	no entry	no entry	solo exons 1,2 10q21.3 = old CYP2C61P
2C-se3[1]	AP000084.1	no entry	NT_011512.10	no entry	no entry	hold	no entry	no entry	solo exon 1, 21q21.2 = old CYP2C63P
2C-se4[1]	AF002223.2	no entry	NT_011726.13	no entry	no entry	hold	no entry	no entry	solo exon 1, Xq28 = old CYP2C64P
2D6 2D gene cluster map	see related sequences under the Entrez Gene link	NM_000106	see reference assembly under the Entrez Gene link	NP_000097	124030	2625	Hs.648256 (117 ESTs)	CYP2D6	deleted in genome assembly 22q13.1 Structures 2F9Q
2D7	see sequences under the Unigene link	no entry	no entry	no entry	no entry	hold	Hs.333497 (33 ESTs)	no entry	alt. spliced 2D7 polymorphic full length 22q13.1
2D7P1/2D7P	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2624	no entry	CYP2D7P1	2D cluster at 22q13.2
2D7P2/2D7AP	multiple	no entry	NG_005574	no entry	no entry	2627	no entry	CYP2D7AP	97.4% to 2D7P on a 44kb XbaI frag.
2D8P1/2D8P	multiple	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2628	no entry	CYP2D8P1	87.3% to 2D7P
2D8P2/2D7BP	X58468	no entry	no entry	no entry	no entry	2626	no entry	CYP2D8P2	96.8% to 2D7P on a 44kb XbaI frag. Also called 2D8BP
2E1	see related sequences under the Entrez Gene link	NM_000773	see reference assembly under the Entrez Gene link	NP_000764	124040	2631	Hs.12907 (264 ESTs)	CYP2E1	10q26.3
2F1	see related sequences under the Entrez Gene link	NM_000774	see reference assembly under the Entrez Gene link	NP_000765	124070	2632	Hs. 558318 (7 ESTs)	CYP2F1	19q13.2
2F1P	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	18851	no entry	CYP2F1P	missing N-term
2G1P	see related sequences under the Entrez Gene link, also S80998 S80999	no entry	see reference assembly under the Entrez Gene link	no entry	601133	2633	no entry	CYP2G1P	94% missing exons 4, 5, 6
2G2P	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	15653	no entry	CYP2G2P	in frame stops and frameshifts
2J2 2J gene cluster map	see related sequences under the Entrez Gene link	NM_000775	see reference assembly under the Entrez Gene link	NP_000766	601258	2634	Hs.152096 (177 ESTs)	CYP2J2	1p32.1
2R1	see related sequences under the Entrez Gene link	NM_024514	see reference assembly under the Entrez Gene link	NP_078790	608713	20580	Hs. 371427 (144 ESTs)	CYP2R1	11p15.2
2S1	see related sequences under the Entrez Gene link	NM_030622	see reference assembly under the Entrez Gene link	NP_085125	no entry	15654	Hs.98370 (211 ESTs)	CYP2S1	19q13.2
2T2P	multiple	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	18852	erroneously joined to EGLN2 entry	CYP2T2P	2T1 rat is expressed
2T3P	AC008962	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	18853	no entry	CYP2T3P	2T1 rat is expressed
2U1	see related sequences under the Entrez Gene link	NM_183075	see reference assembly under the Entrez Gene link	NP_898898	610670	20582	Hs.109087 (177 ESTs)	CYP2U1	4q25 synonym P450TEC
2W1	see related sequences under the Entrez Gene link	NM_017781	see reference assembly under the Entrez Gene link	NP_060251	no entry	20243	Hs.272795 (51 ESTs)	54905	7p22.3 NP_seq incomplete
2AB1P	AC068644.15	no entry	NT_005612.15	no entry	no entry	hold	no entry	no entry	3q27.1 = old CYP2D31P, 75% to mouse 2ab1
2AC1P	AC022650.3	no entry	NT_007592.14	no entry	no entry	hold	no entry	no entry	6p12.3 = old CYP2C57P 68% to rat 2AC1 (XM_236969.1)
3A 3A gene cluster map	see related sequences under the Entrez Gene link	no entry	see reference assembly under the Entrez Gene link	no entry	no entry	2635	no entry	CYP3A cluster	3A subfamily entry
3A3X	multiple	no entry	no entry	no entry	no entry	hold	no entry	CYP3A4	discontinued no. = 3A4
3A4	see related sequences under the Entrez Gene link	NM_017460	see reference assembly under the Entrez Gene link	NP_059488	124010	2637	Hs. 651218 (354 ESTs)	CYP3A4	7q22.1 Structures 2J0D 2J0C 1W0G 1W0F 1W0E 1TQN
3A4-ie1b	multiple	no entry	NT_007933.14	no entry	no entry	hold	no entry	no entry	7q22.1 partial internal exon
3A5_v1	see related sequences under the Entrez Gene link	NM_000777	see reference assembly under the Entrez Gene link	NP_000768	605325	2635	Hs.150276 (214 ESTs)	CYP3A5	7q22.1 = wt CYP3A5
3A5_v2