CHARLES J. SHERR
PROFESSOR

EDUCATION:
A.B. 1966, Oberlin College, Oberlin, Ohio
Ph.D. 1972, New York University Graduate School of Arts and Sciences
M.D. 1972, New York University School of Medicine

RESEARCH INTERESTS: Oncogenes and tumor suppresors; hematopoietic growth factors and their receptors; regulation of cell cycle progression.

CURRENT RESEARCH SUPPORT:
P01 CA20180-18, Project #4 "CSF-1 Responsive G1 Cyclins in Hematopoietic Malignancy" P.I., Dr. C.J. Sherr, 25% effort
Investigator, Howard Hughes Medical Institute, supports remainder of P.I.'s program
Herrick Foundation Chair, Tumor Cell Biology.

PUBLICATIONS: (Only selected refereed publications appearing since 1985 are listed.)
91. Sherr, C.J., Rettenmier, C.W., Sacca, R., Roussel, M.F., Look, A.T. and Stanley, E.R. (1985) The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell, 41, 665-676.
105. Roussel, M.F., Dull, T.J., Rettenmier, C.W., Ralph, P., Ullrich, A., and Sherr, C.J. (1987) Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). Nature, 325, 549-552.
116. Heard, J.M., Roussel, M.F., Rettenmier, C.W., and Sherr, C.J (1987) Multilineage hemato-poietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene. Cell, 51, 663-673.
129. Roberts, W.M., Look, A.T., Roussel, M.F., and Sherr, C.J. (1988) Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes. Cell, 55, 655-661.
130. Roussel, M.F., Downing, J.R., Rettenmier, C.W., and Sherr, C.J. (1988) A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential. Cell, 55, 979-988.
148. Roussel, M.F. and Sherr, C.J. (1989) Mouse NIH/3T3 cells expressing human CSF-1 receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor. Proc. Natl. Acad. Sci. USA, 86, 7924-7927.
162. Borzillo, G.V., Ashmun, R.A., and Sherr, C.J. (1990) Macrophage lineage switching of murine early pre-B lymphoid cells expressing transduced fms genes. Mol. Cell Biol., 10, 2703-2714.
164. Shurtleff, S.A., Downing, J.R., Rock, C.O., Hawkins, S.A., Roussel, M.F., and Sherr, C.J. (1990) Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase. EMBO. J., 9, 2415-2421.
165. Roussel, M.F., Shurtleff, S.A., Downing, J.R., and Sherr, C.J. (1990) A point mutation at tyrosine 809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of fos and junB genes. Proc. Natl. Acad. Sci. USA, 87, 6738-6742.
171. Downing, J.R, Shurtleff, S.A., and Sherr, C.J. (1991) Peptide antisera to human colony- stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase. Mol. Cell. Biol., 11, 2489-2495.
172. Matsushime, H., Roussel, M.F., Ashmun, R.A., and Sherr, C.J. (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell, 65, 701-713.
173. Roussel, M.F., Cleveland, J.L., Shurtleff, S.A., and Sherr, C.J. (1991) MYC rescue of a mutant CSF-1 receptor impaired in mitogenic signaling. Nature, 353, 361-363.
174. van Daalen Wetters, T., Hawkins, S.A., Roussel, M.F., and Sherr, C.J. (1992) Random mutagenesis of CSF-1 receptor (FMS) reveals multiple sites for activating mutations within the extracellular domain. EMBO J., 11, 551-557.
182. Matsushime, H., Ewen, M.E., Strom, D.K., Kato, J-Y., Hanks, S.K., Roussel, M.F., and Sherr, C.J. (1992) Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D-type G1 cyclins. Cell, 71, 323-334.
185. Kato, J-Y., Matsushime, H., Hiebert, S.W., Ewen, M.E., and Sherr, C.J. (1993) Binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4. Genes & Devel., 7, 331-342.
189. Ewen, M.E., Sluss, H.K., Sherr, C.J., Matsushime, H., Kato, J-Y., and Livingston, D.M. (1993) Functional interactions of the retinoblastoma protein with mammalian D-type cyclins.
Cell, 73, 487-497.
193. Quelle, D.E., Ashmun, R.A., Shurtleff, S.A., Kato, J-Y., Bar-Sagi, D., Roussel, M.F., and Sherr, C.J. (1993) Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes & Devel., 7, 1559-1571.
195. Kato, J-Y. and Sherr, C.J. (1993) Inhibition of granulocyte differentiation by G1 cyclins, D2 and D3, but not D1. Proc. Natl. Acad. Sci. USA, 90, 11513-11517.
198.Polyak, K., Kato, J-Y., Solomon, M.J., Sherr, C.J., Massagué, J., Roberts, J.M., and Koff, A.M. (1994) p27Kip1, a cyclin-cdk inhibitor, links transforming growth factor-b and contact inhibition to cell cycle arrest. Genes & Devel., 8, 9-22.
203. Matsushime, H., Quelle, D.E., Shurtleff, S.A., Shibuya, M., Sherr, C.J., and Kato, J-Y. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14, 2066-2076.
210. Kato, J-Y., Matsuoka, M., Polyak, K., Massagué, J., and Sherr, C.J. (1994) Cyclic AMP-induced G1 phase arrest mediate by an inhibitor (p27Kip1) of cyclin-dependent kinase-4 activation. Cell, 79, 487-496.
214.Hirai, H., Roussel, M.F., Kato, J-Y., Ashmun, R.A., and Sherr, C.J. (1995) Novel INK4 proteins, p18 and p19, are specific inhibitors of cyclin D-dependent kinases CDK4 and CDK6. Mol. Cell. Biol., 15, 2672-2681.
216.Roussel, M.F., Theodoras, A.M., Pagano, M., and Sherr, C.J. (1995) Rescue of defective mitogenic signaling by D-type cyclins. Proc. Natl. Acad. Sci. USA, 92, 6837-6841.