THE MOST RECENT ALIGNMENT OF HETERODIMERIC GUANYLYL CYCLASES

1                MSRRKISSESFSSLGSDYLETSPEEEGECPLSR  hum alpha2

1          MFCAKLKDLQITGDCPFSLLAPGQVPREPLGEATGSGPA  bov alpha1
34   LCWNGSRSPPGPLEPSPAAAAAAAAPAPTPAASAAAAAATAGARR  hum alpha2

1                               MYGFVNHALELLVIRNYG  bov beta1
40   STPGQPGVCPGVPDKNPPGRLPRRKTSRSRVYLHTLAESICKLIF  bov alpha1
79   VQRRRRVNLDSLGESISRLTAPSPQTIQQTLKRTLQYYEHQVIGY  hum alpha2

18   PEVWEDIKKEAQLDEEGQFLV-RIIYDDSKTYDLVAAASKVLNLN  bov beta1
85   PEFERLNLALQRTLAKHKIKENRKSLEREDFEKIVVDQAIAAGVP  bov alpha1
124  RDAEK-NFHNISNRCSYADHSNKE--EIEDVSGIL-QTANILGLK  hum alpha2

1    MEAILKLFGEYFFKFCKMSGYDRMLRTLGGNLTEFIE--NLDALH  rat beta2
62   AGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQ--NLDALH  bov beta1
129  VEIIKESLGEELFKICYEEDEY-ILGVVGGTLKDFLNSFSTLLKQ  bov alpha1
166  FEEIQKRFGEEFFNICFHENERVLR-AVGGTLQDFFN--GFDALL  hum alpha2

43   SYLALSYQEMNAPSFRVEEGADG-AMLLHYYSDRHGL--CHIVPG  rat beta2
104  DHLATIYPGMRAPSFRCTDADKGKGLILHYYSEREGL--QDIVIG  bov beta1
173  SSHCQEAEKKGRFEDASILCLDKDPDVLYVYYFFPKRITSLILPG  bov alpha1
207  EHIRTSFGKQATLESPSFLCKELPEGTLMLHYFHPHHIVGFAMLG  hum alpha2

86   IIEAVAKDFFDTDVAMSILDMNEEVERTGKKEHVVFLVVQKAHRQ  rat beta2
148  IIKTVAQQIHGTEIDMKVIQ-------------------------  bov beta1
218  IIK------------------------------------------  bov alpha1
253  MIK------------------------------------------  hum alpha2

131  IRGAKASRPQGSEDSQADQEALQGTLLRMKERYLNIPVCPGEKSH  rat beta2
168  ---------QRNEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQ  bov beta1
222  -------AAARILYETEVEVSSTPSRFHQDCREFVDQPCELYSVH  bov alpha1
256  -------AAGKKIYRLDVEVEQVANEKLCSDVSNPGNCSCLTFLI  hum alpha2

176  STAVRASVLFGKGPLRDTFQPVYPERLWVEEEVFCDAFPFHIVFD  rat beta2
204  ESRISPYT-------------------------FCKAFPFHIIFD  bov beta1
260  IRSARPHPPPGK-PVSSL---VIPASL------FCKTFPFHFMLD  bov alpha1
294  KECENTNIMKNLPQGTSQ----VPADLRISINTFCRAFPFHLMFD  hum alpha2

221  EALRVKQAGVNIQKYVPG-ILTQKFALDEYFSIIHPQVTFNISSI  rat beta2
224  RDLVVTQCGNAIYRVLPQ-LQPGNCSLLSVFSLVRPHIDISFHGI  bov beta1
295  RDMSILQLGHGIRRLMSRRDVQGKPHFDEYFEILTPKISQTFSGI  bov alpha1
335  PSMSVLQLGEGL-RKQLRCDTHKVLKFEDCFEIVSPKVNATFERV  hum alpha2

265  CKFINSQFVLKTRKEMM---------PKARKSQPMLKLRGQMIWM  rat beta2
268  LSHINTVFVLRSKEGLLDVEKSECEDELTGTEISCLRLKGQMIYL  bov beta1
340  MTMLNMQFLVRVRR----------WDNSMKKSSRVMDLKGQMIYM  bov alpha1
379  LLRLSTPFVIRTK-----PEASGSENKD-----KVMEVKGQMIHV  hum alpha2

301  ESLRCMIFMCSPNVRSLQELEESKMHLSDIAPHDTTRDLILLNQQ  rat beta2
313  PEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQ  bov beta1
380  VESSSILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQ  bov alpha1
414  PESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQ  hum alpha2

346  RLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVA  rat beta2
358  FREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVA  bov beta1
425  ARAQDGLKKRLGKLKATLEQAHQALEEEKRKTVDLLCSIFPSEVA  bov alpha1
459  AKAQDGLKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVA  hum alpha2

391  NQLKEGRKVAAGEFETCTILFSDVVTFTNIC----AACEPIQIVN  rat beta2
403  NELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVN  bov beta1
470  RQLWQGHAVQAKRFGNVTMLFSDIVGFTAICS----QCSPLQVIT  bov alpha1
504  QQLWQGQQVQARKFDDVTMLFSDIVGFTAICA----QCTPMQVIS  hum alpha2

432  MLNSMYSKFDRLTSVH---DVYKVETIGDAYMVVGGVPVPVESHA  rat beta2
448  LLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHA  bov beta1
506  MLNALYTRFDRQCGEL---DVYKVETIGDAYCVAGGLHKESDTHA  bov alpha1
545  MLNELYTRFDHQCGFL---DIYKVETIGDAYCVAAGLHRKSLCHA  hum alpha2

474  QRVANFALGMRISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDK  rat beta2
493  RSICHLALDMMEIAGQV--QVDGESVQITIGIHTGEVVTGVIGQR  bov beta1
548  VQIALMALKMMELSHEVVSP-HGEPIKMRIGLHSGSVFAGVVGVK  bov alpha1
588  KPIALMALKMMELSEEVLTP-DGRPIQMRIGIHSGSVLAGVVGVR  hum alpha2

519  MPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRAL-----KNKG  rat beta2
536  MPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMTPENSDPQ  bov beta1
592  MPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFT  bov alpha1
631  MPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFI  hum alpha2

559  FEIVRRGEIEVKG-KGKMTTYFLIQNLNATEDEIMGRPSAPADGK  rat beta2
581  FHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETEQDEN         bov beta1
637  PRSREELPPNFPSDIPGICH-FLEAYQQGTTSKPWFQKKDVEEAN  bov alpha1
676  PRSREELPDNFPKEIPGICY-FLEVRTGPKPPKPSLSSSRIKKVS  hum alpha2

603  EVCTPGNQVRKSPAVPRNTDHQQQVYKGDPADASNEVTLAGSPVA  rat beta2
681  ANFLGKASGID                                    bov alpha1                                        
720  YNIGTMFLRETSL                                  hum alpha2

648  GRNSTDAVNNQPSPDETKTSVVASGPVLSAFCVVL            rat beta2