VINCENT KIDD
ASSOCIATE PROFESSOR

EDUCATION:
B.S. 1978, University of Oklahoma, Norman, OK
Ph.D. 1982, University of Texas Graduate School of Biomedical Sciences, Houston, TX

RESEARCH INTERESTS: Mammalian cell cycle, checkpoint control, regulation of apoptotic signal transduction, tumor suppressor genes.

CURRENT RESEARCH SUPPORT:
NIH 2 R01 GM 44088 "Structure and function of PITSLRE kinases" February 1, 1991 - June 30, 1999; $659,526.
NIH 1 R01 CA 67938 "PITSLRE kinase gene alterations in neuroblastoma" July 1, 1995 - June 30, 1998; $517,426.

PUBLICATIONS: (selected from a total of 65)
28. Bunnell, B., Heath, L.S., Adams, D.E., Lahti, J.M., and Kidd, V.J. (1990) Elevated expression of a 58-kDa protein kinase cDNA leads to changes in the CHO cell cycle.
Proc. Natl. Acad. Sci. USA, 87, 7467-7471.
29. Kidd, V.J., Luo, W., Xiang, J., Tu, F., Easton, J., McCune, S., and Snead, M. (1991) Regulated expression of a cell division control-related protein kinase during development.
Cell Growth Differ., 2, 85-93.
30. Pouncey, L., Easton, J., Heath, L.S., Grenet, J., and Kidd, V.J. (1991) 1-4 galactosyltransferase gene expression is regulated during entry into the cell cycle and during the cell cycle. Somatic Cell Mol. Genet., 17, 435-443.
31. Eipers, P., Barnoski, B., Han, J., Carroll, A., and Kidd, V.J. (1991) Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1 and a highly related sequence to human chromosome 15. Genomics, 11, 621-629.
32. Kidd, V.J., Luo, W., Xiang, J., Tu, F., Easton, J., McCune, S., and Snead, M. (1991) Regulated expression of a cell division control-related protein kinase during development.
Cell Growth Differ., 2, 85-93.
33. Pouncey, L., Easton, J., Heath, L.S., Grenet, J., and Kidd, V.J. (1991) 1-4 galactosyltransferase gene expression is regulated during entry into the cell cycle and during the cell cycle. Somatic Cell Mol. Genet., 17, 435-443.
34. Eipers, P., Barnoski, B., Han, J., Carroll, A., and Kidd V.J. (1991) Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1 and a highly related sequence to human chromosome 15. Genomics, 11, 621-629.
35. Kraft, A.S., Shue, W.S., Xiang, J., Pouncey, L., Kidd, V.J. (1992) Regulation of the p58 cell division control-related protein kinases during phorbol 12-myristate 13-acetate-induced terminal differentiation of U937 cells. Oncogene, 7, 501-506.
36. Aicher, W.K., McGhee, M.L., McGhee, J.R., Moldoveanu, Z., Kidd, V.J., Tomana, M., Mestecky, J., Eldridge, J.H., Meyer, T.F., and Kiyono, H. (1992) IgA-binding properties of Fc receptors for IgA (FcR): -galactosyltransferase and an SC-like molecule on murine T cells.
Scan. J. Immunol., 35, 469-486.
37. Grenett, H.E., Eipers, P.G., Kidd, V.J., Bounelis, P., and Fuller, G.M. (1992) Chromosomal localization of a human cDNA containing a DIDS binding domain which demonstrates high homology to yeast omnipotent suppressor 45. Somatic Cell Mol. Genet., 18, 97-102.
38. Eipers, P., Lahti, J.M., and Kidd, V.J. (1992) Structure and expression of the human p58 protein kinase chromosomal gene. Genomics, 13, 613-621.
39. Kidd, V.J., Nesbitt, J.E., and Fuller, G.M. (1992) Chromosomal localization of the IL-6 receptor signal transducing subunit, gp130. Som. Cell Mol. Genet., 18, 477-483.
40. Kidd, V.J. (1992) Cell division control-related protein kinases: Putative origins and functions. Mol. Carcinogenesis, 5, 95-101.
41. Fountain, J.W., Karayiorgou, M., Ernstoff, M.S., Bouchard, B., Houghton, A.N., Lahti, J., Kidd, V.J., Housman, D.E., and Dracopoli, N.C. (1992) Homozygous deletions of human chromo-some 9p21 in melanoma. Proc. Natl. Acad. Sci. USA, 89, 10557-10561.
42. Mock, B.A., Padlan, C., Kozak, C.A., and Kidd, V.J. (1994) The gene for mouse p58cdc2L1 (CDC2l1) protein kinase maps to distal mouse chromosome 4. Mammalian Genome., 5, 191-192.
43. Easton, J. and Kidd, V.J. (1994) Analysis of the 5' flanking sequences from the human protein kinase p58 (PITSLRE1)-encoding gene. Gene, 145, 279-282.
44. Xiang, J., Lahti, J.M., Kidd, V.J. (1994) 2-Aminopurine overrides a late telophase delay created by ectopic expression of the PITSLRE1 protein kinase. Biochem. Biophys. Res. Comm., 199, 1167-1173.
45. Lahti, J.M., Valentine, M., Xiang, J., Jones, B., Amann, J., Grenet, J., Richmond, G., Look, A.T., and Kidd, V.J. (1994) Alterations in the PITSLRE protein kinase gene complex on chromo-some 1p36 in childhood neuroblastoma. Nature Genetics, 7, 370-375.
46. Xiang, J., Lahti, J.M., Grenet, J., Easton, J., and Kidd, V.J. (1994) Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. J. Biol. Chem., 269, 15786-15794.
47. Jeddi, P.A., Lund, T., Bodman, K.B., Lydard, P.M., Pouncey, L., Heath, L.S., Kidd, V.J., and Delves, P.J. (1994) Reduced galactosyltransferase mRNA levels in IgG galactosylation-deficient MRL-1pr/1pr strain mice. Immunology, 83, 484-488.
48. Lahti, J.M., Xiang, J., Heath, L.S., Compana, D., and Kidd, V.J. (1995) PITSLRE protein kinase activity is associated with apoptosis. Mol. Cell. Biol., 15, 1-11.
49. Li, H., Grenet, J., Valentine, M., Lahti, J.M., and Kidd, V.J. (1995) Structure and expression of chicken PITSLRE protein kinase gene and mRNAs. Gene, 153, 237-242.
50.Okuda, T., Hirai, H., Valentine, V.A., Shurtleff, S.A., Kidd, V.J., Lahti, J.M., Sherr, C.J., and Downing, J.R. Molecular cloning, expression pattern and chromosomal localization of human p19INK4d, an inhibitor of cyclin-D dependent kinases. Genomics, in press.
51. Li, H., Grenet, J., and Kidd, V.J. Sequence and expression of avian cyclin D2.
Gene, in press.
52. Nelson, M.A., Thompson, F., Taetle, R., Wymer, J., Redman, C., Barks, J., Massey, K., Easton, J., Lahti, J.M., and Kidd, V.J. Abnormalities in the PITSLRE protein kinase gene complex on chromosome band 1p36 in melanoma. Cancer Res., submitted.
53. Amann, J., Valentine, M., Kidd, V.J., and Lahti, J.M. Localization of Chl1-related helicase genes to human chromosome 12p11 and 12p13: Conservation between these genes and conserved human telomeric-associated DNA. Genomics, submitted.
54. Li, H., Lahti, J.M., Valentine, M., Saito, M., Reed, S.I., Look, A.T., and Kidd, V.J. Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: Deletion of the CCNC gene in human tumors. Genomics, submitted.