SUSAN E. CARLSON
PROFESSOR

EDUCATION:
B.S. 1969, Washington State University, Pullman, WA
Ph.D. 1975, Iowa State University, Ames, IA
NIHLB Postdoctoral Fellow 1975-1978, University of Wisconsin, Madison, WI
NIHLB Postdoctoral Fellow 1978-1979, University of South Florida, Tampa, FL

RESEARCH INTERESTS: I am interested in the role of dietary fatty acid intake on lipid metabolism. Currently my interest is in determining the biochemical and functional effects of the essential n-3 and n-6 fatty acids and their longer chain metabolites on the developing retina and brain of infants. Our studies have a direct clinical application because human milk contains long-chain n-3 and n-6 fatty acids, but formulas available for infants do not. We are presently involved in separate randomized, double-blind trials of n-3 and n-6 fatty acid supplementation in term and preterm infants.

CURRENT RESEARCH SUPPORT:
National Institute of Child Health and Human Development: September 1, 1993 - August 31, 1997; $427,442
Ross Laboratories, Columbus, OH: July 1, 1992 - June 30, 1995; $325,000
Mead Johnson, Evansville, IN: September 1, 1995 to December 31, 1996; $115,000

SELECTED PUBLICATIONS:
Carlson, S.E., DeVoe, P.W. And Barness, L.A. (1982) The effect of human milk and infant formulas with different polyunsaturated to saturated fat ratios on circulating high density lipoproteins. J. Pediatr. Gastroenterol. Nutr., 1, 303-309.
Putnam, J.C., Carlson, S.E., DeVoe, P.W., and Barness, L.A. (1982) The effect of variations in dietary fatty acids on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in human infants. Am. J. Clin. Nutr., 36, 106-114.
Carlson, S.E. Carver, J.D., and House, S.G. (1986) High fat diets varying in ratios of polyunsaturated to saturated fat and linolenic acid: A comparison of rat neural and red cell membrane phospholipid. J. Nutr., 116, 718-725.
Carlson, S.E., Rhodes, P.G., and Ferguson, M.G. (1986) Docosahexaneoic acid status of preterm infants at birth and following feeding with human milk or formula. Am. J. Clin. Nutr., 44, 798-804.
Carlson, S.E., Rhodes, P.G., Rao, V., and Goldgar, D.E. (1987) Effect of fish oil supplementation on the omega-3 fatty acid content of red blood cell membranes in preterm infants. Pediatr. Res., 21, 507-510.
Liu, C-CF., Carlson, S.E., Rhodes, P.G., Rao, V., and Meydrech, E.F. (1987) Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. Pediatr. Res., 22, 292-296.
Peeples, J.M., Carlson, S.E., Werkman, S.H., and Cooke, R.J. (1991) Vitamin A status of preterm infants during infancy. Am. J. Clin. Nutr., 53, 1455-1459.
Carlson, S.E., Cooke, R.J., Rhodes, P.G., Peeples, J.M., Werkman, S.H., and Tolley, E.A. (1991) Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: Phospholipid fatty acids. Pediatr. Res., 30, 404-412.
Carlson, S.E., Cooke, R.J., Rhodes, P.G., Peeples, J.M. and Werkman, S.H. (1992) Effect of vegetable and marine oils in preterm infant formulas on blood arachidonic and docosahexaenoic acids. J. Pediatr., 120, S159-S167.
Carlson, S.E., Cooke, R.J., Werkman, S.H. And Tolley, E.A. (1992) First year growth of preterm infants fed standard compared to marine oil n-3 supplemented formula. Lipids, 27, 901-907.
Carlson, S.E., Werkman, S.H., Peeples, J.M., Cooke, R.J., and Tolley, E.A. (1993) Arachidonic acid status correlates with first year growth in preterm infants. Proc. Natl. Acad. Sci., 90, 1073-1077.
Carlson, S.E., Werkman, S.H., Rhodes, P.G., and Tolley, E.A. (1993) Visual acuity development in healthy preterm infants: Effect of marine oil supplementation. Am. J. Clin. Nutr., 58, 35-42.
Werkman, S.H., Peeples, J.M., Cooke, R.J., Tolley, E.A., and Carlson, S.E. (1994) Effect of vitamin A supplementation of intravenous lipids on early vitamin A intake and status of premature infants. Am. J. Clin. Nutr., 59, 586-592.
Carlson, S.E., Werkman, S.H., Peeples, J.,M., and Wilson, W.M.III (1994) Long chain fatty acids and early visual and cognitive development of preterm infants. Eur. J. Clin. Nutr. 48, S27-S30.
Carlson, S.E. (1994) Lessons learned from infants randomized to marine oil-supplemented formulas in nutrition trials. J. Pediatr., 125, S33-S38.
Carlson, S.E., Peeples, J.M., Werkman, S.H., and Koo, W.W.K. (1995) Plasma retinol and retinol binding protein concentrations in premature infants fed preterm formula past hospital discharge. Eur. J. Clin. Nutr., 49, 134-136.
Rajaram, S., Carlson, S.E., Koo, W.W.K., Kelly, D.P., and Rangachari, A. (1995) Insulin-like growth factor (IGF)-I and IGF-binding protein 3 during the first year in term and preterm infants. Pediatr. Res., 37, 581-585.
Rajaram, S., Carlson, SE., Koo, W.W.K., and Braselton, E.W. (1995) Plasma mineral concen-trations in preterm infants fed a nutrient-enriched formula after hospital discharge. J. Pediatr., 126, 791-796.
Carlson, S.E., Werkman, S.H., and Tolley, E.A. The effect of long chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. Am. J. Clin. Nutr., in press.
Carlson, S.E. Arachidonic acid status of human infants: Influence of gestational age at birth and diets with very long chain n-3 and n-6 fatty acids. J. Nutr., in press.
Werkman, S.H. and Carlson, S.E. A randomized trial of visual recognition memory and attention of preterm infants fed marine oil docosahexaenoic acid until 9 months past term. Lipids , in press.
Carlson, S.E. And Werkman, S.H. A randomized control trial of visual recognition memory and attention of preterm infants fed marine oil docosahexaenoic acid until 2 months past term. Lipids, in press.
Carlson, S.E., Ford, A.J., Werkman, S.H., Peeples, J.M., and Koo, W.W.K. Visual acuity and fatty acid status of term infants fed human milk and formula with and without docosahexaenoate and arachidonate from egg yolk lecithin. Pediatr. Res., in press.