172 sequences intron locations are coded phase 00, phase 1, phase 2

12a4m ------------------------------------------------MLKVRSALSLIQ 12

12a5m ------------------------------------------------MLKGRIALNILQ 12

12A4ps ------------------------------------------------MLKVRTGLSIIQ 12

12A5ps ------------------------------------------------MLKVRSGLSIIQ 12

12c1m ------------------------------------------------MLRLTV-KHGLR 11

12c1ps ------------------------------------------------MIRRAVVQQGIR 12

12e1m --------------------------------------------------MLSTQWNANK 10

12e1ps --------------------------------------------------MLSQQLNAKR 10

12d1m -------------------------------------------------MNTLSSARSVA 11

12d1ps ------------------------------------------------MNAWQSLTRRLA 12

12b2m ---------------------------------------MWKYSNKIIYRNVSGNQLWFN 21

12B2ps ---------------------------------------MWKNTMKTVRRQSAAHQLFNA 21

49A1m MSGLRKTSIALMRRSTSS----TTILPHSG---GVGGAVSPPSSGVGVATEIEKSIAMQR 53

49A1ps MSGLRKTSFALMRRSTYSGSATATMLPHAGPGPGTGVDGAAPPSGVGVATEIEKSIARQR 60

301a1m ---MNNLSLKAWRSTVSC----G----------PNLRQCVPRISGAGSR-----RAQCRE 38

301A1ps ------MNKLPVRACTAS----A----------SSLRRTVSRISGSGLLPNEKQRLEIRD 40

302a1m ------------------------------------------------------------

302A1ps ------------------------------------------------------------

314a1m ------------------------------------MAVILLLALALVLGCYCALHRHKL 24

314a1ps ------------------------------------MAVILLLALALVLGCYCAIHRHKI 24

315a1m ----------------------------------------------MTEKRERPGPLRWL 14

315a1ps ------------------------------------------------MNRKRTSLLHWL 12

6a2m -----------------------------------------------------------M 1

6a2ps -----------------------------------------------------------M 1

6a8m --------------------------------------------------------MALT 4

6a18m --------------------------------------------------------MQLT 4

6a8ps --------------------------------------------------------MGVT 4

6a9m --------------------------------------------------------MGVY 4

6a21m --------------------------------------------------------MSVG 4

6a21ps ------------------------------------------------------MAVGVG 6

6a17m ------------------------------------------------------------

6a23m -----------------------------------------------------------M 1

6A17ps -----------------------------------------------------------M 1

6A23ps -----------------------------------------------------------M 1

6a20ps -----------------------------------------------------------M 1

6a20m -----------------------------------------------------------M 1

6a19m -----------------------------------------------------------M 1

6a22m -----------------------------------------------------------M 1

6A22ps -----------------------------------------------------------M 1

6a13m -----------------------------------------------------------M 1

6A13ps -----------------------------------------------------------M 1

6a14m -----------------------------------------------------------M 1

6A14ps ------------------------------------------------------------

6a15pm ------------------------------------------------------------

6a16m -----------------------------------------------------------M 1

6A16ps -----------------------------------------------------------M 1

6u1m -----------------------------------------------------------M 1

6u1ps --------------------------------------------------------MDLL 4

317a1m -------------------------------------------------------MWIIF 5

317a1ps -------------------------------------------------------MWIIF 5

6g1m ------------------------------------------------------------

6G1ps ------------------------------------------------------------

6w1m ------------------------------------------------------------

6w1ps ------------------------------------------------------------

6v1m -----------------------------------------------------------M 1

6v1ps -----------------------------------------------------------M 1

6g2m ------------------------------------------------------------

6g2ps ------------------------------------------------------------

6t1m ------------------------------------------------MIAVFSLIAAAL 12

6t2pm -----------------------------------------------MVIAFFIFLCAAL 13

6t1ps -------------------------------------------MILVIGVLFIAATVAAI 17

6t3m -----------------------------------------------------------M 1

6t3ps -----------------------------------------------------------M 1

9b1m ----------------------------------------------------------MS 2

9b2m ----------------------------------------------------------MA 2

9B2ps ----------------------------------------------------------MV 2

9f2m -----------------------------------------------------------M 1

9f3pm -----------------------------------------------------------M 1

9F2ps -----------------------------------------------------------M 1

9c1m ----------------------------------------------------------MV 2

9c1ps ----------------------------------------------------------MA 2

9h1m ---------------------------------------------------------MDQ 3

9h1ps ---------------------------------------------------------MEK 3

6d2m ------------------------------------------------------------

6d2ps -----------------------------------------------------------M 1

6d4m -----------------------------------------------------------M 1

6d4ps -----------------------------------------------------------M 1

6d5m ------------------------------------------------------------

6D5ps ------------------------------------------------------------

310a1m ------------------------------------------------------------

310a1ps ------------------------------------------------------------

28a5m ----------------------------------------------------------MV 2

28A5ps ----------------------------------------------------------MI 2

28d1m --------------------------------------------------------MCPI 4

28d1ps --------------------------------------------------------MCPI 4

28d2m --------------------------------------------------------MCPV 4

28c1m ----------------------------------------------------------MF 2

28c1ps ----------------------------------------------------------MI 2

309a1m -------------------------------------------------------MFTLV 5

309a1ps -------------------------------------------------------MWTTV 5

309a2m -------------------------------------------------------MYILA 5

309a2ps -------------------------------------------------------MYILV 5

308a1m ------------------------------------------------------------

308a1ps -------------------------------------------------------MLLLL 5

4aa1m -------------------------------------------MHLRLLSPPQLERTTNL 17

4aa1ps ------------------------------------------MQFYTRMTVPQLERATRT 28

4C3m ---------------------------------MSSKVITSLMAESILLSKVGQVISGYS 27

4C3ps ---------------------------------MSSKVISSLMAESILLTKMAQVISGYS 27

4d1m ---------------------------------------------------------MFL 3

4D1ps ---------------------------------------------------------MFL 3

4d1malt ---------------------------------------------------------MWL 3

4D1psalt ---------------------------------------------------------MWL 3

4s3m --------------------------------------------------------MSTL 4

4s3ps --------------------------------------------------------MNTW 4

312a1m ---------------------------------------------------------MFW 3

312a1ps --------------------------------------------------------MVVW 4

4g1m ----------------------------------MAVEVVQETLQQAASSSSTTVLGFSP 26

4G1ps ----------------------------------MTVDTVQETLQHAATS--TSGLGFSP 24

4g15m ------------------------------------MEVLKKDAALGSPS--S------- 15

4G15ps ------------------------------------MEVLKKDAAMGSPS--S------- 15

4d2m ------------------------------------------------------MLGVVG 6

4D2ps --------------------------------------------------------MLAL 4

4d14m ---------------------------------------------------------MYL 3

4d14ps ---------------------------------------------------------MFV 3

4d8m ----------------------------------------------------------ML 2

4d8ps ----------------------------------------------------------ML 2

4ae1m --------------------------------------------------------MLVV 4

4AE1ps --------------------------------------------------------MLMA 4

4d20m ---------------------------------------------------------MWL 3

4D20ps --------------------------------------------------------MLLL 4

4d21m ---------------------------------------------------------MWI 3

4e2m -------------------------------------------------------MWFVL 5

4e2ps -------------------------------------------------------MWFVL 5

4e1m -------------------------------------------------------MWIVL 5

4e1ps -------------------------------------------------------MWFAL 5

4e3m -------------------------------------------------------MWLAV 5

4e3ps -------------------------------------------------------MWLAV 5

4ad1m -------------------------------------------------------MFLIA 5

4AD1ps -------------------------------------------------------MFLIA 5

4p1m -------------------------------------------------MIILWLILALS 11

4p3m -------------------------------------------------MLILWLVGAFI 11

4p1ps -------------------------------------------------MIVFLLTVALC 11

4P2ps -----------------------------------------------TMIVVLWLTVALC 13

4P3ps -------------------------------------------------MITLWLTVALC 11

4p2m -----------------------------------------------MMICLLWISVAIL 13

4ac1m ------------------------------------------------MWIALLGIPILL 12

4AC1ps ------------------------------------------------MLIALLGTPLLL 12

4ac2ps ------------------------------------------------MFELLLGVPLIV 12

4ac2m -----------------------------------------------MFLEVLFAAPLVI 13

4ac3m ------------------------------------------------MWIALLGSSLLI 12

311a1m -----------------------------------------------------------M 1

311a1ps ------------------------------------------------------------

316a1m ---------------------------------------------------------MIL 3

316A1ps ---------------------------------------------------------MIL 3

313a2m ----------------------------------------------------------MI 2

313a3m ----------------------------------------------------------MD 2

313a1m ----------------------------------------------------------ML 2

313C1ps ----------------------------------------------------------MY 2

313C2ps ----------------------------------------------------------MI 2

313a5m ----------------------------------------------------------ML 2

313a4m ----------------------------------------------------------ML 2

313a4ps ----------------------------------------------------------ML 2

313A4bps ----------------------------------------------------------ML 2

313b1m ----------------------------------------------------------ML 2

313b1ps --------------------------------------------------------MLLG 4

318a1m ----------------------------------------------------------MH 2

318A1ps ----------------------------------------------------------MH 2

18a1m -------------------------------MLADSYLIKFVLRQLQVQQ-DGDAQHLLM 28

18a1ps -------------------------------MLADSYLIKFLLRQLQVQQQDAGAQHLLM 29

306A1m -------------------------------------MSADIVDIGHTGWMPSVQSLSIL 23

306A1ps --------------------------------MSASFATASASASVFDWLPLSGHSFCLL 28

303a1m ----------------------------------------------------------MF 2

303A1ps ----------------------------------------------------------MF 2

305a1m --------------------------------------------------------MSAL 4

305A1ps --------------------------------------------------------MSAL 4

304a1m --------------------------------------------------------MITE 4

304a1ps --------------------------------------------------------MLTE 4

307a1m -------------------------------------MLAALIYTILAILLSVLATSYIC 23

307a1ps ---------------------------------------MSAVYSVLAILLAIIITSYIR 21

307a2pm -------------------------------------MLTSVFYVLFAIAITIILISYVF 23

307a2pps -------------------------------------MFFSVCYLIIAIGITAIVISYIL 23

2A 2B 2C 2D 2E

12a4m SQKATLSLATQKR----WQTNVATAEARE--------DSEWLQAKPFEQIPRLN---MWA 57

12a5m SQKPIVFSASQQR----WQTNVPTAEIRN--------DPEWLQAKPFEEIPKAN---ILS 57

12A4ps AQKAALSVSCPLR----WQTTAAVAEPRN--------DEEWLQARPFKQIPST----TFL 56

12A5ps AQKAALSVSSPLR----WQTTAAVAEPRN--------DEEWLQARPFEQIPST----TFL 56

12c1m ANSQLAATRNPD---------ASSYVQQL--------ESEWEGAKPFTELPGP----TRW 50

12c1ps ARSSLAEVQVISKKNLDPAAASSSYMEQL--------EGEWSTAKPFEEIPGP----TRW 60

12e1m QISRQIYQLCR--------------------------VLNLEEAKPYADIPGP----SKL 40

12e1ps QASCQIYQIYRNE------------------------TISLEQAKPYAEVPGP----SKF 42

12d1m IYVGPVRSSRSAS--------VLAHEQAK--------SSITEEHKTYDEIPRP----NKF 51

12d1ps VATGPIRSLRGSS--------AQAQAQRS---------VEDVEARPFSEVPRP----GRL 51

12b2m RNSSVGGTLSQQT----QLELADS---RI--------DEKWQQARSFGEIPGP----SLL 62

12B2ps RDLSLNRTLGQQT----HLELLDKSPPRT--------DERWQQAKSYGELPGP----NGW 65

49A1m LRTGESSNPKKLNVSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIG 113

49A1ps LRQGQSETAKKLNVSHLAATAVPATETAT--ATATRTASPTAGVRPYSEVPGPYPLPLIG 118

301a1m SSTGVATCPHLADSEEASAP---RIHSTS----------EWQNALPYNQIPGPKPIPILG 85

301A1ps SSTGVAACPHLLEPEETAAPTTPRIHSTP----------EWQNALPYNQIPGPKPLPILG 90

302a1m ---MLTKLLK------------ISCTSRQC-----------TFAKPYQAIPGPRGPFGMG 34

302A1ps ---MLTKLLK------------ISCTSRQC-----------TFAKPFEAMPGPRGPWGLG 34

314a1m ADIYLRPLLKNTLLEDFYHAELIQPEAPK------------RRRRGIWDIPGPKRIPFLG 72

314a1ps GATYLKPLLKNTPLEDCYHATPVVPEQQKS-----------RRRRSIWDIPGPQRIPFLG 73

315a1m RHLLDQLLVRILSLSLFRSRCDPPPLQRFP-------ATELPPAVAAKYVPIPR-VKGLP 66

315a1ps QQLLRTLLVRLLCQFKSKAGLTKATAG-----------SNRCRSKGGEIVPIPR-VKGLP 60

6a2m FVLIYLLIAISS---------LLAYLYHRN---------FNYWNRRGVPHDAP--HPLYG 41

6a2ps LILIYLVIAVGS---------LVAYLLHRN---------FQYWKRKGVPHDPP--HPFYG 41

6a8m YILFQVAVALLA---------ILTYYIHRK---------LTYFKRRGIPFVAP--HLIRG 44

6a18m YFLFQVAVALLA---------IVTYILHRK---------LTYFKRRGIPYDKP--HPLRG 44

6a8ps YVLLQVAVALLA---------IVTYYVYRR---------LSYFKSRGIPHDTP--HLILG 44

6a9m SVLLAIVVVLVG---------YLLLKWRRA---------LHYWQNLDIPCEEP--HILMG 44

6a21m TVLLTALLALVG---------YLLMKWRST---------MRHWQDLGIPCEEP--HILMG 44

6a21ps ALLLWTLVALVV---------YLLLKWLLG---------RQYWQNLGIPCEEP--HWLLG 46

6a17m MLLLALIVVILS---------LLVFAARRR---------HGYWQRRGIPHDEV--HPLFG 40

6a23m SLLLTLIALLVS---------LLLFMARRR---------HGYWQRRGIPHDVP--HPIYG 41

6A17ps SLVLALIAIVVS---------LVLFAARRR---------HGYWQRRGIPHDVP--HPLFG 41

6A23ps SLVLALIAIVVS---------LVLFAARRR---------HEYWQNLGIPCEEP--HWLLG 41

6a20ps AIIIVLLVGVIS---------LAVWWVHQN---------FSYWKRRGIPHDPP--NIPKG 41

6a20m AVMIVLLIGVIT---------FVAWYVHQH---------FNYWKRRGIPHDEP--KIPYG 41

6a19m AILLGLVVGVLT---------LVAWWVLQN---------YTYWKRRGIPHDPP--NIPLG 41

6a22m LDVVALLLIALA---------VGFWFVRTR---------YSYWTRRGIGSEPA--RFPVG 41

6A22ps LDVIALLLITLA---------IGFWYVRTR---------LSYWARRGIGHVRP--TFPMG 41

6a13m LTLLVLVFTVGL---------LLYVKLRWH---------YSYWSRRGVAGERP--VYFRG 41

6A13ps WTLLALVLVAGA---------LIYSRLLEH---------YDYWRRKGVAGEKP--VLFLG 41

6a14m LFTIALVGVVLG---------LAYSLHIKI---------FSYWKRKGVPHETP--LPIVG 41

6A14ps --------MALA---------LAYNFYRNT---------YSYWERKGVPNERP--LPLIG 32

6a15pm ------------------------------------------------------------

6a16m DFTLLLLTSLLS---------FLLGYLRYR---------FTYWELRGIPQLRP--HFLFG 41

6A16ps GFVLILLTSLLS---------GVLGYLRCK---------YNYWQINGVKQLRA--HFLFG 41

6u1m HRTLLTALGALS---------VVYALVKFS---------LGYWKRRGILHEKP--KFLWG 41

6u1ps HRALLTAVGALS---------LFYALVKVS---------LGYWKRRGILHEKP--KFFWG 44

317a1m LIIGLLVLGLLV---------LLIIAARYQ---------RDYWRYLDIPHERP--KKLWP 45

317a1ps TIIGLVVLGLVI---------LLIMAARYQ---------RDYWHYLNIPHERP--KKLWP 45

6g1m MVLTEVLFVVVA------ALVALYTWFQRN---------HSYWQRKGIPYIPP--TPIIG 43

6G1ps MALTEALFLIVG------ALSAVYIWFQRN---------HSYWQRKGIPYIPP--TPIIG 43

6w1m ---MLLLLLLGS------LTIVFYIWQRRT---------LSFWERHGVKYIRP--FPVVG 40

6w1ps -MSTELLFLIAT------VAIVFYVWHKRR---------HSFWKRHGVKEIGP--LPILG 42

6v1m VYSTNILLAIVT------ILTGVFIWSRRT---------YVYWQRRRVKFVQP--THLLG 44

6v1ps VYSTNILLAIVT------ILTAVFVWSRRT---------YVYWQRRRVKFVQP--AHLLG 44

6g2m -MELVLLILVAS------LIGIAFLALQQH---------YSYWRRMGVREIRP--KWIVG 42

6g2ps -MVLGLFLLVVI------FLATICFLLQQH---------YAYWRRRGVRELRP--HWILG 42

6t1m AVGSLVLLPVVLRGGCLLVVTIVWLWQILH---------FWHWRRLGVPFVP--AAPFVG 61

6t2pm AVGSVVLLPLIA-------LLAVWLWQRRH---------FRIWRRLGVPYLP--AAPVLG 55

6t1ps GLLFFVVFPLVCAAG-LIIFGIIWLWQRHH---------FCHWLRLGVPYIR--ATPFVG 65

6t3m LLIWLLLLTIVT----------LNFWLRHK---------YDYFRSRGIPHLPPSSWSPMG 42

6t3ps VSLWLLMLGILS----------IYLWLRQR---------YSYFERHNIVHLPVSAWTPLG 42

9b1m FVEICLVLATIG--------LLLFKWSTGT---------FKAFEGRNLYFEKP--YPFLG 43

9b2m LIEICLALVVIG--------YLIYKWSTAT---------FKTFEERKLYFEKP--YPFVG 43

9B2ps CLEICLAILVLG--------FMIYKWSTAT---------HRAFDERGVYFEEP--KPFFG 43

9f2m LWEFFALFAIAA--------ALFYRWASAN---------NDFFKDRGIAYEKP--VLYFG 42

9f3pm LWEFLALFAIAT--------ALFYRWASAN---------NDFFKDRGIAYEKP--VLYLG 42

9F2ps LLEFVALLGIAF--------ALFYRWATAN---------NEFFKEKGIPFAKP--KLYFG 42

9c1m FVELSIFVAFIG--------LLLYKWSVYT---------FGYFSKRGVAHEKP--IPLLG 43

9c1ps FEVLLALGALIG--------FLLYKWAEPP---------VRFFLKRGVVHEAP--VPLLG 43

9h1m SMIALALFIILL--------VLLYKWSVAK---------YDVFSERGVSHEKP--WPLIG 44

9h1ps WIVVLSLVAVLL--------VLLYKWSVAK---------YGILTERGVPHAQP--KPLLG 44

6d2m MWTILLTILIAG---------LLYRYVKRH---------YTHWQRLGVDEEP--AKIPFG 40

6d2ps WAILTLLTLALG---------LLYQFVRRH---------YSSWQRLGVDEET--PKIPMG 41

6d4m FSLILLAVTLLT---------LAWFYLKRH---------YEYWERRGFPFEKH-SGIPFG 42

6d4ps FSLIVLAGTLLA---------LGWFYLKHH---------YQYWERRGFPFDRQ-STIPFG 42

6d5m MIGIYLLIAAVT---------LLYVYLKWT---------FSYWDRKGFPSTG--VSIPFG 40

6D5ps MIGILLLVAAVS---------LLYVYLKWT---------FSYWDRQGFPSAG--VTIPFG 40

310a1m -MWLLLPILLYS---------AVFLSVRHI---------YSHWRRRGFPSEK--AGITWS 39

310a1ps -MWLLLPILLYS---------VLFLAVRHI---------YSHWRRKGFPSER--AGISWS 39

28a5m LITLTLVSLVVG---------LLYAVLVWN---------YDYWRKRGVPGPKP--KLLCG 42

28A5ps LITLALGLATVG---------LLYLLMTWN---------FDHWRKRRVPGPKP--KIPTG 42

28d1m STALFVIAAILA---------LIYVFLTWN---------FSYWKKRGIPTAKS--WPFVG 44

28d1ps CAVLLLLATLLT---------LIYIFLTWN---------FGYWKRRGIQTAKA--WPLVG 44

28d2m TTFLVLVLTLLV---------LVYVFLTWN---------FNYWRKRGIKTAPT--WPFVG 44

28c1m GSLLLGIATLLG---------AIYAFLVSN---------FGHWRRRGVTEPRA--LPLFG 42

28c1ps GSLLLAVGALAT---------LVYGFLVWN---------FGHWRARGIKEPRA--LPLLG 42

309a1m GLCLTIVHVAFA---------VVYFYLTWY---------HKYWDKRGVVTAEP--LTILG 45

309a1ps GLLLGAVHVAFA---------AVYLYLTWH---------HKYWQKRGVLTAEP--LTILG 45

309a2m SLALILLHLLVL---------PIYLYLTWH---------HKYWRKRGLVTARP--LTLLG 45

309a2ps TLGLIVVHLLLL---------PLYVYLTWH---------HRFWRKRGLVTARP--LTMLG 45

308a1m -MLPLVLFILLA---------ATLLFWKWQ---------GNHWRRLGLEAPFG--WPLVG 39

308a1ps LLLLLLLLFFLG---------TLWRRLAWS---------NSHWRRRVVSGPQG--CPLVG 45

4aa1m ELCSILILLVISLS------IYTFYATLNT---------YLRSVLLSLRLTGPPSLPFLG 62

4aa1ps ELCSILALLVISLS------IYLFYAHLDT---------YLRSVILSLRLSGPPTLPILG 73

4C3m PITVFLLGSILIFL------VVYNKRRSR-------------LVKYIEKIPGPAAMPFLG 68

4C3ps PITIFLLASIALFL------VVYNKRRSR-------------LVKHIEKIPGPAAMPFLG 68

4d1m VIGAILASALFVGL------LLYHLKFKR-------------LIDLISYMPGPPVLPLVG 44

4D1ps LLGALLASGLFVAL------LVYQLKFKR-------------VIEVISYMPGPPVLPLVG 44

4d1malt LLSLVLLLAIIALE------MRRFLRNMR-------------------TIPGPLPLPLLG 38

4D1psalt SLVFGAVGTVLVLG------LFSWLPFCRR---------RRRISELAELLPGPKPWPLLG 48

4s3m ALVAFVLWAAFLRY------LPKILNFLR-------------LQRFAKTLPGPTIGELIA 45

4s3ps ALMAFALWALFLRY------LPQILTFLR-------------LQRFAKTLPGPSVSELIA 45

312a1m LGFGLLLLALSLYL------LYVFERQSR-------------IDRLTHKWPAPPALPFIG 44

312a1ps LGLCLLLIVLSLYL------LYAFERQTR-------------IDRLTHNWPAPPSLPILG 45

4g1m MLTTLVGTLVAMAL------YEYWRRNSR-------------EYRMVANIPSPPELPILG 67

4G1ps MLTTLVGTIVALGL------YEYWRRNTR-------------EYRMVANIPSPPGLPLLG 65

4g15m VFYFLLLPTLVLWY------IYWRLSRAH-------------LYRLAGRLPGPRGLPIVG 56

4G15ps VFYFLLLPTLVLWY------IYWRLSRAH-------------LYRLAGRLPGPRGLPIVG 56

4d2m VLLLVAFATLLLWD------FLWRRRGN-------------------GILPGPRPLPFLG 41

4D2ps VVFLVALTTVLVWD------YFWRKRRND--------------IL--HYMPGPRGLPLVG 42

4d14m ELFAILLATALAWD------YMRKRRHNK--------------MYAEAGIRGPKSYPLVG 43

4d14ps ELLVLLLTVALVWD------YLVGRKHKR--------------LFDRAGITGPKAWPLVG 43

4d8m LFLLVVLLFGAGWI------IHLGQADRR--------------RK-VANLPGPICPPLIG 41

4d8ps LLVLVLLLVAVGWL------VHRGQAERR--------------RA-VSNLPGPMCPPLLG 41

4ae1m LLVALLVTRLVASL------FRLALKELR--------------HPLQGVVPSVSRVPLLG 44

4AE1ps LLLTMALTLIVAWL------LQLALREMR--------------HPLRGFVPSVSRVPLVG 44

4d20m TLITGALILLLTWD------FGRKRQRVL--------------AFEKSAIPGPISIPILG 43

4D20ps TLAFGALAVLLTWD------FVRKRQRAA--------------TLERSKISGPLSLPVLG 44

4d21m LLGIAVLIMTLVWD------NSRKQWRVN--------------TFEKSRILGPFTIPIVG 43

4e2m YIFLALPLLLVAYL------ELS--TFRR--------------RRVLNKFNGPRGLPLMG 43

4e2ps YLFLALPLLLVAYL------ELS--TFRR--------------RRALNKFKGPSRLPIVG 43

4e1m CAFLALPLFLVTYF------ELG--LLRR--------------KRMLNKFQGPSMLPLVG 43

4e1ps YLVLALPLLWLAYL------ELK--SLRR--------------RRVLNKFKGPKVLPVVG 43

4e3m LALLVLPLITLVYF------ERK--ASQR--------------RQLLKEFNGPTPVPILG 43

4e3ps LALLALPLLVLVYF------ELR--ASRR--------------RRMLKVFNGPAPVPVLG 43

4ad1m IAIILATILVFKGV------RIFNYIDHM--------------AGIMEMIPGPTPYPFVG 45

4AD1ps IAIILATILVFKGV------KIFNYIDHM--------------AGIMEMIPGPTPYPFVG 45

4p1m ALLYWLHRANKDYH------ILSFFTKRIR---------LKDGTPVEIIAPIAKGKTIFG 56

4p3m VLIQWIYRLNRDYC------ILGFFAKRIR---------TKNGQNPESIAPLVKGSTIFA 56

4p1ps ALVLWLYRINKDYY------ILAFFSRRVR---------TKDGRPVESILPSPKGRTIFA 56

4P2ps VIVHWLYRVNKDYY------IMAFFSRRVR---------TKDGRPVESIVPMIKGRTVFA 58

4P3ps VVIHWLYQVNKDYY------ILAFFSRRVY---------TRDDRPVESLVPSPKGRTIFA 56

4p2m VVIHWIYKVNKDYN------ILAFFARRVQ---------TKDGKPLDSLVPMIKGRTVFA 58

4ac1m AVLTLLLKHINKTY------FILSLTKRVR---------TEDGSPLESKVAIMPGKTRFG 57

4AC1ps LGVWLLLQRLNRTY------FILSLTRRVR---------TEDGSPLESKVAVMPGTTRFG 57

4ac2ps LLCCVLLRRLNRKY------FVLSLCKRLQ---------AEDGSPLESKIAVMPGRTRFG 57

4ac2m FIFRKLWAHLNRTY------FILSLCKRIR---------TEDGSLLESKIYVAPSKTRFG 58

4ac3m GALWLLLRQLNKTY------FILSLCKRVR---------TADGSPLESKVFVVPGKTRFG 57

311a1m ALWPLLLITLTIWI------LVRKWTLLR----------------LGSSLPGPWAFPLLG 39

311a1ps ------------------------------------------------------------

316a1m TATFICFCLASAFN------YFRARRQRS----------------LIKNLKGPFTWPLMG 41

316A1ps TTTFLCFCVASAIN------YFRTRRQRS----------------LIKNLGGPFSWPLMG 41

313a2m VIQLLIAASLILWI------RFLWSRRKLY---------MLMMQLP-----GRMGLPLLG 42

313a3m TFQLLLAVGVCFWI------YFLWSRRRLY---------MMHFKIP-----GPMGLPILG 42

313a1m TINLLLAVGALFWI------YFLWSRRRLY---------FLMLKIP-----GPIGLPILG 42

313C1ps SLHLWIAVGILAWI------YFLWSRRRFY---------LLMLRVK-----GPVGYPFLG 42

313C2ps TLQLWIAVGILAWI------YFLWSRRRFY---------LLMLRVK-----GPVGYPFLG 42

313a5m TLQIFEAFAIILCV------YFLWSRRRFY---------IMMLKLP-----GPMGFPFIG 42

313a4m TWTLWCGLLFLLWI------YFLWSRRRFY---------LLTLKIP-----GPLGYPILG 42

313a4ps TWTLWCGLLFVLWI------YFLWSRRRFY---------LLTLKIP-----GPIGYPLLG 42

313A4bps TWSLWCGLLFVLWI------YFLWSRRRFY---------LLTLKIP-----GPIGYPFLG 42

313b1m ASIILSGWLLLAWL------YFLWSRRRYY---------KVAWQLR-----GPIGWPLIG 42

313b1ps TCIILAIWLLLVWT------YFLWTRRRYY---------KAAWQLK-----GPIGWPLIG 44

318a1m LNIALWACGALLAV------LLAWQQRKCW---------RLIWQLNG--WRGVIQQPVLW 45

318A1ps LYVALWVCGTALAL------LLGWQQRKCW---------RLIWQLNG--WRGVAQQPILW 45

18a1m VFLGLLALVTLLQW-------LVRNYRELR-----------------KLPPGPWGLPVIG 64

18a1ps VFLGFLALVSLLQW-------MLRHYRELR-----------------KLPPGPWGLPVIG 65

306A1m LVPGALVLVILYLC-------ERQCNDLMG-----------------APPPGPWGLPFLG 59

306A1ps VVPGLLILIILWLC-------DHQYDRVLG-----------------RPPPGPWGLPWLG 64

303a1m YTVIWIFCATLLAI-------LFGGVRKPK-----------------RFPPGPAWYPIVG 38

303A1ps YAVIWIFFATLLAV-------LLGGVRKPK-----------------RFPPGPRWYPIVG 38

305a1m IFLCAILIGFVIYS-------LISSARRPK-----------------NFPPGPRFVPWLG 40

305A1ps IFLCAILIGFVIYS-------LIKSVQRPK-----------------NFPPGPRFLPWLG 40

304a1m TLLTICAAVFLCLS-------YRYAVGRPS-----------------GFPPGPPKIPLFG 40

304a1ps LLLTICSAAFLYLS-------YRYAVGRPV-----------------GFPPGPPRIPFFG 40

307a1m IIYGVKRRVLQPVK-------TKNSTEINHN-----------AYQKYTQAPGPRPWPIIG 65

307a1ps ILYKSRRRVCVAIR-------NGKSSTESE--------------QIYEQAPGPRPWPIIG 60

307a2pm LLLKCKQKAFVVIG-------LLYQEKKYQ---------------CFDQAPGPHPWPIIG 61

307a2pps IIFKCNEKATVRIG-------LSNPEKAIR---------------KFGQAPGPQPWPIIG 61

3A 3D 3F 3G

3B 3C 3E 3H 3I 3J

12a4m LSMKMSMPGGK--YKNMELMEMFEAMRQDYG----------DIFFMPGIMGNPPFLSTHN 105

12a5m LFAKSALPGGK--YKNLEMMEMIDALRQDYG----------NIIFLPGMMGRDGLVMTHN 105

12A4ps STVRNFMPGGK--YRKLDIVELFQALQDDYG----------DIFYLPGIMGGPSFLTTHN 104

12A5ps STVRNFMPGGK--YSKLDIVNLFKALQDDYG----------NILYLPGMMGGTSYLMTHN 104

12c1m QLFRGFQKGGE--YHQLGMDDVMRLYKKQFG----------DICLIPGLFGMPSTVFTFN 98

12c1ps QLWRGFQKGGE--FHHLDMAELMDLYRSRFG----------DMVRVPGLFGMPTTVFTFK 108

12e1m QLIRAFLPGGL--YKNLPVHEMFLDMNRQYG----------SIFRMPSVAG-TDLVLTMN 87

12e1ps QMIRAFMPGGR--YKNAPAHEMFLDLSRQFG----------GLFRMPSIAG-TDMVLTMN 89

12d1m KFMRAFMPGGE--FQNASITEYTSAMRKRYG----------DIYVMPGMFGRKDWVTTFN 99

12d1ps QFMRSFMPGGE--FSDASIVEFSMGMRRRYG----------DIFILPGMFGRKDWVVTFN 99

12b2m RMLSFFMPGGA--LRNTNLIQMNRLMREMYG----------DIYCIPGMMGKPNAVFTYN 110

12B2ps RMISYFLPGGK--LHNTNLIQMNRRLRVMYG----------DIYRLPGLMGKPDIVFTYN 113

49A1m NSWRFAPLIGT--YKISDLDKVMNELHVNYG----------KMAKVGGLIGHPDLLFVFD 161

49A1ps NSWRFAPLIGT--YKISELDKVMNELHVNYG----------KMAKVGGLIGHPDLLFVFD 166

301a1m NTWRLMPIIGQ--YTISDVAKISSLLHDRYG----------RIVRFGGLIGRPDLLFIYD 133

301A1ps NTWRLMPIIGQ--YTISDVANISSLLHDRYG----------RIVRFGGLIGRPDLLFIYD 138

302a1m NLYNYLPGIGS--YSWLRLHQAGQDKYEKYG----------AIVRETIVPG-QDIVWLYD 81

302A1ps NLYNYMPIIGS--YSFLRLHQAGQDKYERYG----------AIVRETMAPG-QDIVWLYD 81

314a1m TKWIFLLFFRR--YKMTKLHEVYADLNRQYG----------DIVLEVMPSN-VPIVHLYN 119

314a1ps TKWIFFVFFRR--YKMTKLHEVYADLNRRYG----------DIVLEVMPSN-VPIVHLYK 120

315a1m VVGTLVDLIAA--GGATHLHKYIDARHKQYG----------PIFRER-LGGTQDAVFVSS 113

315a1ps VVGTLLDLIAA--GGATHLHKYIDSRHRQYG----------PIFRER-LGGTQDAVFVSS 107

6a2m NMVGFRKN-----RVMHDFFYDYYNKYRKSGF-----------PFVGFYFLHKPAAFIVD 85

6a2ps NLVGFRKN-----RVIHDIFYDYYNKFRTSGS-----------PFVGFFFLQKPAAFIVD 85

6a8m NMEELQKT-----KNIHEIFQDHYNKFRESKA-----------PFVGFFFFQSPAAFVID 88

6a18m NMEGYKKT-----RTVHEIHQEYYNKYRNSKA-----------PFVGFYLFQKPAAFVID 88

6a8ps NMQGVFTK-----RNVHEILKKYYEKYRESKV-----------PFVGFYFFQKPSAFILD 88

6a9m SLTGVQTS-----RSFSAIWMDYYNKFRGTG------------PFAGFYWFQRPGILVLD 87

6a21m SMKGVRTA-----RSFNEIWTSYYNKFRGSG------------PFAGFYWFRRPAVFVLE 87

6a21ps SMWGLRTT-----RTFNDVWTDYYKKYRLSG------------PFAGFYWFQRPAVFVLE 89

6a17m NIKDWPNK-----RHIAEIFRDYYFKYKN-----------SDYPFAGFFFFFTRTAVVTD 84

6a23m NMKDWPKK-----RHIAMIFRDYYTKYKR-----------SVYPFAGFYFFFTRSAVITD 85

6A17ps NIGDWPKK-----RQIAVIFRDYYRKYKN-----------ANYPFAGFYFFFTRSAVVTD 85

6A23ps SMWGLRTT-----RTFNDVWTDYYKKYR------------LSGPFAGFYWFQRPAVFVLE 84

6a20ps NTSELMKT-----RQIADLFRETYFKYKG----------KTDGPFVGFYLYLKKIAIVTD 86

6a20m NTSELMKT-----VHFADIFKRTYNKLRN----------KTDGPFVGFYMYFKRMVVVTD 96

6a19m NTGELWRT-----MPLAGILKRTYLKFRK----------QTDGPFAGFYLYAMKYIVITD 86

6a22m NMEGFRKN-----KHFIDIVTPIYEKFKG-----------NGAPFAGFFMMLRPVVLVTD 85

6A22ps NMDGLRRT-----KHFKDIVTPLYERFKD-----------SGAPFAGIYMMLRPVVLVLD 85

6a13m NMSGLGRD-----LHWTDINLRIYRKFRG------------VERYCGYFTFMTKSLFIMD 84

6A13ps NMSGLGKG-----LHWTDINRRIYEKFSK------------TERFCGYFTFFSKAFFVMD 84

6a14m NMRGIVKK-----YHFRDINQRIYKKFKG------------QGPIAGMYTFFKRTALITD 94

6A14ps NVKGIGTK-----YHFRDINQRIYDKFKG------------VAPFAGMFTFFKRSALIID 75

6a15pm ------------------------------------------------------------

6a16m HFFRLQS------VHYSELLQETYDAFRG------------SAKVAGTYVFLRPMAVVLD 83

6A16ps HFFKMKS------VRLTELLQETYDAFKG------------SALVAGTYVYLRPIAVILD 83

6u1m NIKGVVSG----KRHAQDALQDIYTAYKGRA------------PFVGFYACLKPFILALD 85

6u1ps NIKGVVGG----KRHLQDALQVIYAKYKGRA------------PFVGFFACLKPFVLVLD 88

317a1m IIRQIMTQTLSTEAMKAEHYSAIYKKFKGSG------------PFCGFYALLQPRALILD 93

317a1ps IVRQIVTQSLSTEAMKTAHYSALYSKFKGSG------------PFCGFYALLQPRALILD 93

6g1m NTKVVFKMEN----SFGMHLSEIYNDPRLKDE-----------AVVGIYSMNKPGLIIRD 88

6G1ps NTEPAFKLKN----SFGLHLSEIYSDPKMQDE-----------AVVGVYALNKPCLIIRD 88

6w1m CTREFLTAKV----PFFEQIQKFHEAPGFENE-----------PFVGVYMTHRPALVIRD 85

6w1ps DTVGFLTGRL----PFFDQIRKFHEAPGLENE-----------PIIGVYLAYRPALVIRD 87

6v1m NLSRVLRLEE----SFALQLRRFYFDERFRNE-----------PVVGIYLFHQPALLIRD 89

6v1ps NLSKVLRLEE----SFALQLRRFYFDERFRNE-----------PIVGIYLFHQPALLIRD 89

6g2m NLMGLLNMRM----SPAEFISQLYNHPDAENE-----------PFVGIHVFHKPALLLRD 87

6g2ps NLAGLLSMRD----SPADFMGQLYNHPDALNQ-----------PFVGIHVFHRPALLLRD 87

6t1m NVWNLLRGAC----CFGDQFRELYESKEAAGR-----------AFVGIDVLHNHALLLRD 106

6t2pm ---NVLNVEC----CFGDQFRELYERKEAAGR-----------AIVGINVLHSHALLLRD 97

6t1ps NVWKLLRGSC----CFGDQFRQLYESKEAAGH-----------AYVGIHVLHNHALLLRD 110

6t3m NLGQLLFLRI----SFGDLFRQLYADPRNGQA-----------KIVGFFIFQTPALMVRD 87

6t3ps HLRKLLLLRI----SFGDLFHNIYADPRGGQA-----------KVVGFFLFQTPALMVRD 87

9b1m N-MAASALQ-----KASFQKQISEFYNRTRHH-----------KLVGLFNLRTPMIQIND 86

9b2m N-MAAAALQ-----KSSFQRQLTEFYERTRQH-----------KLVGFFNMRTPMITLND 86

9B2ps N-IGTSMLG-----LTSFHKVLSAFYNRTRGH-----------KVVGFFNLRTPMIQLND 86

9f2m N-MAGMFLR-----KRAMFDIVCDLYTKGGSK-----------KFFGIFEQRQPLLMVRD 85

9f3pm N-MAGMFLR-----KRAMLDIVCDLYTKGGSG-----------KFFGIFAQRQPLLMVRD 85

9F2ps N-MAQMFLR-----QKAMFDIVCDLYNKGGSN-----------KVYGIFEQRQPLMMIRD 85

9c1m N-IPWSVLMG----KESYIKHSIDLHLRLKQH-----------KVYGVFNLRDPLYYLSD 87

9c1ps N-IPLAVLMG----KASYLKHSIAVHMRLKQH-----------KVYGVFNLRDPLFFLSD 87

9h1m N-IPLKAMIG----GMPVLKKMIELHTKHTGS-----------PVYGIYALRDAVFFVRD 88

9h1ps T-IPIRGMFT----GLPVLKYMIEQHMQYQGS-----------RVYGVYALRDPLIFLRD 88

6d2m VMDTVMKQER----SLGMALADIYARHEG--------------KIVGIYMLNKRSILIRD 82

6d2ps ILDTVMKQEM----SLGMVLSDIYKRHKG--------------KIVGIYMMNKRSILVRD 83

6d4m CLDSVWRQEK----SMGLAIYDVYVKSKE--------------RVLGIYLLFRPAVLIRD 84

6d4ps CLDSVWRREK----GMGMAIYDAYQKSKE--------------RFLGIYLLFRPAVLVRD 84

6d5m ALESVTKGKR----SFGMAIYDMYKSTKE--------------PVIGLYLTLRPALLVRD 82

6D5ps ALDSVRRGKR----SFGMAIYDMYNATKE--------------PVMGMYLTLRPALLVRD 82

310a1m FLQKAYRREF----RHVEAICEAYQSGKD--------------RLLGIYCFFRPVLLVRN 81

310a1ps FLHQAYRREF----RHVEAICEAYQMGRE--------------RLLGIYCFFRPVLIVRN 81

28a5m NYPNMFTMKR----HAIYDLDDIYRQYKNKYD------------AVGIFGSRSPQLLVIN 86

28A5ps NYPHMYTMKR----HAIYDLNDIYVKYKNKYD------------AVGIFGGRVPQLLVIS 86

28d1m SFPSVFTQKR----NVVYDIDEIYEQYKNTDS------------IVGVFQTRIPQLMVTT 88

28d1ps SFPSVFTQKR----NMAYDIDEIYRQYKNTES------------VVGVFNTRIPQLMILC 88

28d2m SFPSIFTRKR----NIAYDIDDIYEKYKDTDN------------MVGVFTTRVPQLLVMC 88

28c1m SFPNMIWPRQ----HFTMDMRDIYMHYRNTHS------------YVGCYLLRAPKLLVLE 86

28c1ps SFPNMVWPRQ----HFTMDMRDLYMKYRETDS------------YVGTFLLRSPKLLLLE 86

309a1m SYPGILINKSR---SLILDVQDVYNKYKDKYR------------TVGTFITRQPQLLVLD 90

309a1ps TYPGVLADKSR---SLILDVQEVYNKYKEKHR------------AVGTFLTRQPQLLVLD 90

309a2m TYPGLLTRKS----NLVFDVQKIYDKYKGKHR------------AVGVFVTRQPQILVLD 89

309a2ps TYPGLLTRTS----NLVEDVQKVYDKYKGKHR------------AVGVFVTRQPQILVLD 89

308a1m NMLDFALGRR----SYGEIYQEIYTRNPGLKY------------VGFYRLFNEPAILVRD 83

308a1ps NMASFALGQR----SYGEVYEQIYRQHPELRY------------VGFYRLFNEPAILVRD 89

4aa1m N--CMLVT------DKDLMRRCAGKAFDLYG------------SLVRIWVLLFPFFAVLE 102

4aa1ps N--CLLIK------DKDLMRNQAAKAFDLYG------------SLVRIWVLFFPFFVVLQ 113

4C3m NAIEMNV-------DHDELFNRVIGMQKLWGTR-I--------GINRVWQGTAPRVLLFE 112

4C3ps NAIEMNV-------DHDELFNRVIGMQKLWGTR-L--------GINRVWQGTSPRVLLFE 112

4d1m HGHHFIGK------PPHEMVKKIFEFMETYSK--D--------QVLKVWLGPELNVLMGN 88

4D1ps HGHHFIGK------PPHELVKQITEFMSKYAK--D--------ETLKVWLGPELNVLMAN 88

4d1malt NAHIFLGL------TPAEACLKIGELAERHG------------DTFGLFLGPSYSVMLFN 80

4D1psalt DAHLFFGL------SPAEACLMMGQLAEKYG------------DTFKLRLGPCFSVMFFH 90

4s3m NV------------KKGEILNWLKELREKHG------------PVFRIWFGKDLMVMFTD 81

4s3ps NV------------KKGEILNWLKELRERHG------------PVFRIWFGKDLMVMFSD 81

312a1m HLHILAKL------VGPHPLRRATEMINEHLH--D--------HRAKLWMGTKLYLVDCN 88

312a1ps HLHILAKL------VGPHPFRRATELVNTHLK--D--------HRGKLWLGTKLYLVDCN 89

4g1m QAHVAAGL------SNAEILAVGLGYLNKYG------------ETMKAWLGNVLLVFLTN 109

4G1ps QAHMVAGL------SNAEILNVGLGYLNKYG------------ETMKAWLGNVLLVFLTN 107

4g15m HLFDVIG-------PASSVFRTVIRKSAPFE------------HIAKMWIGPKLVVFIYD 97

4G15ps HLFDVIG-------PASSVFKTVIRKSAPFE------------HIAKMWIGPKLVVFIYD 97

4d2m NLLMYRGL------DPEQIMDFVKKNQRKYG------------RLYRVWILHQLAVFSTD 83

4D2ps NALMYRGL------DAEQIMGFVSKNRNKYG------------PLYKVWVLNQLAVFSTD 84

4d14m NAPLLINE------SPKTIFDMQFRLIAEFG------------KNIKTQMLGESGFMTAD 85

4d14ps NAPLMINE------SPKTVFDLQWRLIQTHG------------KNVRCQILQDRGFMTAD 85

4d8m AMQLMLRL------NPKTFIKVGREYVLKFG------------HLQRVWIFNRLLIMSGD 83

4d8ps ALHIMSSM------NPKTFIKVSGENMRKYG------------PLQRVWILNRLLIMSAD 83

4ae1m AAWQMRSF------QPDNLHDKFAEYVKRFG------------RSFMGTVLGHVVMVTAE 86

4AE1ps AAWQMRSF------QPDNLHEKFAEYVERFG------------RSFMASVCGQVIMVTAE 86

4d20m CGLQALHL------GAENIIGWVGEKFDKYG------------KTFRFWILGESLIYTKD 85

4D20ps NGLQALDL------GAENIVDWVEESFRLYG------------KTFRMWILGESLIYTKD 86

4d21m NGLQALTL------RPENFIQRFGDYFNKYG------------KTFRLWILGECLIYTKD 85

4e2m NAHQMGK-------NPSEILDTVFSWWHQYGK-----------DNFVFWIGTYSNVLVTS 85

4e2ps NAHQAGK-------NPTEILDQVFSWWHQYGK-----------DNFRFWIGSYSNLIITN 85

4e1m NAHQMGN-------TPTEILNRFFGWWHEYGK-----------DNFRYWIGYYSNIMVTN 85

4e1ps NAHQLGR-------TPPEILGQMFEWWYQHDK-----------DNFRYWIGYYPNLMVTR 85

4e3m NANRIGK-------NPAEILSTFFDWWYDYGK-----------DNFLFWIGYSSHIVMTN 85

4e3ps NANRVGN-------TPAEILATIFDWWQEYGK-----------DNFVFWIGYTPHLAVTN 85

4ad1m NLFQFGL-------KPAEYPKKVLQYCRKYDF-----------QGFRSLVFLQYHMMLSD 87

4AD1ps NIFQFGL-------KPAEYPKKVLQYCRKYDF-----------QGFRSLVFLQYHMMLSD 87

4p1m NTLDLYG-------RDHAGVFNYSRERAKEMGT----------SYIEYVFGKAIYNIIDA 99

4p3m NSFDLYG-------KDHSGVFEHSRDCAKKLGK----------SYAEYAMGTAIYNVIDA 99

4p1ps NCFDMYG-------KDLAGVFSYSRELSQRLGE----------SYLEYGMGVPLLNIIDA 99

4P2ps NCFDLLG-------KDTDQVFTHLRQLAKNSGD----------SYLQYSMGFSNFNVIDA 101

4P3ps HCFDLYG-------KDNAGVFKFTRDLSKTLGK----------SYVRYVVGMPIYNVIDA 99

4p2m NCFDLLG-------KDTDQVFTHLRQLAKNSGD----------SYLQYSMGFSNFNVIDA 101

4ac1m NNLDILN-------FTPASVFNFVRESTAKAKGQ---------NYLWYFLYAPMYNVVRP 101

4AC1ps NNLDVLN-------CTPSSLFNFLRDSAAKAQGR---------NFLWYFLFAPMYNVIRA 101

4ac2ps NNFDLLN-------FTPSTVFNFMRDSCANARGR---------NYLWYFFGSPMYNVIRA 101

4ac2m NNFDLVN-------FTSESIFNFMRDASAKAKGR---------NYLWYFFHAPMYNIVRA 102

4ac3m NNLDLLN-------LTPANIFSYIRESTAKANGQ---------NYIWNFLFAPEYNIVRA 101

311a1m NAQMVGK------RLPEYIFLVFTELRDRFG------------ATYRLRLGPQLWVFLHS 81

311a1ps ------------------IFLVFTELRDRFG------------ATYRLWLGPQLWVFLHT 30

316a1m AMHKLLFL------TPINFFQRSTEYLTKYG------------TFSRCWVFHRLFIPLAD 83

316A1ps AMHKLLFL------KPQNFFQRSHEYLAKYG------------AVTRLWVFHRLFMPLAD 83

313a2m NSVRYLIIS-------RGRMSSRTTYMDKHG------------STYMAWIGTTPIVITRD 83

313a3m IAFEYLITY-------KRKMSIRTKYMDIYG------------STCLVWVGPTPFVITRD 83

313a1m SSLENIITY-------KRKLSFRTKYLNKYG------------STILTWMGPVPFIVTRD 83

313C1ps VAVEYLRN--------KHNMEQRSKQFQEYG------------PTNLTWIGSVPVLVTCE 82

313C2ps SVVGFLRN--------KRNIGLAGKVAEKYG------------PTFLTWMGTVPVLVTSE 82

313a5m LAFEYIRL--------KRKIRLRTILFKIYG------------KTVLTWIGLTPVLVTCE 82

313a4m MAHWLMRR--------EDILNAFGCFLDKHG------------PTIFSWLGPIPFMIVSD 82

313a4ps MAHKLMRR--------EDILNEFGIYMAKHG------------PTIFSWLGPIPFMIVSE 82

313A4bps MAHKLIHR--------EDILNEFGIYLAKHG------------PTIMSWLGPIPFVIASD 82

313b1m MGLQMMNP--------ETFLQYMDGLSRQFK------------APFISWMGTSCFLYIND 82

313b1ps MGLQMMNT--------ETFLQYMDKLSHKFK------------APFVSWMGTSCFLYVND 84

318a1m LLLCINLHP-------NSILEKVSQYRVHFQ------------RPLAVLVGTRVLLYIDD 86

318A1ps FLLCINLHP-------NSILERVTQMRKYFQ------------RPLAILVGTRVLVYIDD 86

18a1m YLLFMGSEK----------HTRFMELAKQYGS------------LFSTRLGSQLTVVMSD 102

18a1ps YLLFMGNEK----------HTRFMELAKQYGS------------LFSTRLGSQLTVVMSD 103

306A1m YLPFLDARAP---------HKSLQKLAKRYGG------------IFELKMGRVPTVVLSD 98

306A1ps YLPFLSRRAP---------HKSLQALARRYGG------------IYQLRMGSVKAVILSD 103

303a1m SALQVSQLRC----RLGMFCKVIDVFARQYVNP---------YGFYGLKIGKDKVVIAYT 85

303A1ps SALQISQLRC----RLGMFCKVIDVLASRYVNP---------YGFFGLKIGKDKVVIAYT 85

305a1m NTLQFRKEAS----AVGGQHILFERWAKDFRS-----------DLVGLKLGREYVVVALG 85

305A1ps NTLQFRKEAR----AVGGQHILFGQWAQRYQS-----------QLLGLKLGQEYVVVALG 85

304a1m SYLFMLIINF----KY--LHKAALTLSRWYKS-----------DIIGLHVGPFPVAVVHS 83

304a1ps SYLFLLLINY----KY--LHKAALTLTRWYKS-----------DIIGLHVGKFPVAVVHS 83

307a1m NLHLLDRYRD----SP---FAGFTALAQQYGD------------IYSLTFGHTRCLVVNN 106

307a1ps NLNVLDKYRD----NP---FEGFTELAKKYGD------------IYSLTFGHTRCLVVNN 101

307a2pm NINLLGRFQY----NP---FYGFGTLTKKYGD------------IYSLSLGHTRCIVVNN 102

307a2pps NLDLLGRFKS----NP---FEGLGALTKQYGD------------IYSLTLGHSRCLVVNS 102

4A 4F 4H

4B 4C 4D 4E 4G 4I

12a4m PQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVVNPVL 165

12a5m PKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPSQGKSWGDFRSIVNPVL 165

12A4ps PKDFEVVFRNEGVWPNRPGSDTLRYHRQTHRKDFFQGVEGVIPTQGKTWSDFRSTVNPVL 164

12A5ps PKDFEVVFRNEGVWPHRPGSDTLRYHRKTHRKDFFQGVEGAIPTQGKTWSDFRSAVNPVL 164

12c1m VETFEKVYRTEGQWPVRGGAEPVIHYRNKRKDEFFKNCMGLFGN-GAEWGKNRSAVNPVL 157

12c1ps VENFERIYRAEGQWPVRGGADPVLHYRANRKDGFFKDCVGLFSN-GPEWGRLRSAANPVL 167

12e1m PQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPIL 147

12e1ps PQDYATVFRNEGQWPHRRSFTTVEYFRKVRRPEVFGEYDGLLSGNGAAWGKMRTAVNPIL 149

12d1m TKDIEMVFRNEGIWPRRDGLDSIVYFREHVRPDVYGEVQGLVASQNEAWGKLRSAINPIF 159

12d1ps TGDIATVFRNEGAWPHREAFDSIVHFRQHIRPDVYGRTLGLTVGQGEDWGKMRSAVNPIF 159

12b2m PDDFEMTYRNEGVWPIRIGLESLNYYRKIHRPDVFKGVGGLASDQGQEWADIRNKVNPVL 170

12B2ps PEDFELTYRNEGVWPIRIGLESFSYYRKVKRPDVFGGIGGLVSEQGKDWADIRNKVNPVL 173

49A1m GDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHIL 221

49A1ps GDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHIL 226

301a1m ADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGDLGGVVGVHGEPWREFRSRVQKPV 193

301A1ps ADEIEKCYRSEGPTPFRPSMPSLVKYKSVVRKDFFGELGGVVGVHGEPWRQFRSRVQKPV 198

302a1m PKDIALLLNE-RDCPQRRSHLALAQYRKSRPD--VYKTTGLLPTNGPEWWRIRAQVQKEL 138

302A1ps PKDIAKLLNE-RDCPQRRSHLALAQYRRQRPH--VYKTTGLLPTNGPEWWRLRSQLQKEL 138

314a1m RDDLEKVLKYPSKYPFRPPTEIIVMYRQSRPD--RYASVGIVNEQGPMWQRLRSSLTSSI 177

314a1ps REDLEKVLKYPSKYPFRPPTEIIVMYRQSRPD--RYASVGIVNEQGPMWQLLRTSLTSSI 178

315a1m ANLMRGVFQHEGQYPQHPLPDAWTLYNQQHAC-----QRGLFFMEGAEWLHNRRILNRLL 168

315a1ps APLMRGVFLHEGQYPQHPLPDAWTLYNQRHAC-----QRGLFFMEGAEWLHNRRILNHLL 162

6a2m TQLAKNILIKDFSNFADRGQFHNGR--------DDPLTQHLFNLDGKKWKDMRQRLTPTF 137

6a2ps TKLAKNILIKDFSNFADRGQFHNER--------DDPLTQHLFNLDGKRWKELRQRLSPTF 137

6a8m LELAKQILIKDFSNFSNKGIFYNEK--------DDPISAHLFNLDGAQWRLLRNKLSSTF 140

6a18m LELAKQILIKNFSNFTDKGIYYNEK--------DDPMSAHLFNLDGPQWRLLRSKLSSTF 140

6a8ps LDLAKHILIKDFSNFSDKGLFYNEK--------DDPISAHLFNLDGPQWKVLRNKLTSTF 140

6a9m ISLAKLILIKEFNKFTDRGFYHNTE--------DDPLSGQLFLLDGQKWKSMRSKLSYTF 139

6a21m TSLAKQILIKEFNKFTDRGFFHNPE--------DDPLSGQLFLLDGQKWRTMRNKLSSTF 139

6a21ps PSLAKLILIKEFNKFTDRGFFHNPE--------DDPLSGQLFLLDGHKWKSMRHKLSSTF 141

6a17m MELLKRVLIKDFNHFENRGVFYNEI--------DDPLSATLFSIEGQKWRHLRHKLTPTF 136

6a23m LELVKRVLIKDFNHFENRGIFYNEI--------DDPLSATLFSIEGQKWRHLRHKLTPTF 137

6A17ps LDLVKRVLIKDFNHFENRGIFYNEI--------DDPLSATVFSIEGQKWRHLRHKLTPTF 137

6A23ps PSLAKLILIKEFNKFTDRGFFHNPE--------DDPLSATVFSMKGQKWRHLRHKLTPTF 136

6a20ps IDFVKTVLIREFDKFHDRGLFHNEK--------DDPLTNHLVAIEGQKWRQLRQKMTPTF 138

6a20m IDFAKTVLIREFDKFHDRGVFHNER--------DDPLSANLVNIDGQKWKTLRQKLTPTF 148

6a19m VDFVKTVLIRDFDKFHDRGVYHNEK--------DDPLTNNLATIEGQKWKNLRQKLTHTF 138

6a22m LELAKQILIQDFANFEDRGMYHNER--------DDPLTGHLFRIDGPKWRPLRQKMSPTF 137

6A22ps LDLAKEVLIRDFANFEDRGMYHNER--------DDPLTGHLFRIDGPKWRPLRHKMSPTF 137

6a13m LELIRDIMIRDFSSFADRGLFHNVR--------DDPLTGNLLFLDGPEWRWLRQNLTQVF 136

6A13ps LELIKKITISDFSSFADRGLFHNVK--------DDPLTGNLLFLDGPEWRWLRQNLTQVF 136

6a14m LDFIKQVMIKDFSYFQDRGAFTNPR--------DDPLTGHLFALEGEEWRAMRHKLTPVF 146

6A14ps LDLIKQVLIKDFQYFQDRGVFNNVR--------DDPLTGHLLTLEGDEWRSMRQKLTPVF 127

6a15pm ------------------------------------------------------------

6a16m LDLVKAVLIRDFNNFVDRRSFHG-----------DPLTANLFNLQGEEWRNLRTKLSPTF 132

6A16ps LDLAKTILDKDFDKFVDRRNFHK-----------EPLMDNLFNAQGEEWCTLRKKLTPMF 132

6u1m LKLVHQIIFTDAGHFTSRGLYSNPS--------GEPLSHNLLQLDGHKWRSLHAKSAEVF 137

6u1ps LELVRHILVTHAGNFTTRGLYSNDG--------SEPLSGNLLQLDGHKWRALHAQSTGVF 140

317a1m RELIRQIMIKDFWNFNDRGLYCNQK--------SDPLSGDLYALRGESWKEMRQKLDPSL 145

317a1ps RELIRQIMIKDFWNFNDRGLYCNQK--------TDPLSGDLFAMRGQSWKEMRQKLDPSL 145

6g1m IELIKSILIKDFNRFHNRYARCDPHG-------DPLGYNNLFFVRDAHWKGIRTKLTPVF 141

6G1ps PELIKSVMVKDFNRFHNRYGRCDPHG-------DPLGSNNLFFVRDTHWKDIRTKLTPVF 141

6w1m LELIKTVMIKKFQYFNNRVLQTDPHN-------DALGYKNLFFARSPGWRELRTKISPVF 138

6w1ps LDLVKTVMIKKFSYFTNRKLQTDPHD-------DALGYNNLFFVRSPEWKELRNKISPVF 140

6v1m LQLVRTVLVEDFVSFSNRFAKCDGRS-------DKMGALSLFLAKQPEWREIRTRLAPAF 142

6v1ps LSLVRTVLVEDFVSFSNRFAKCDLRH-------DKMGSLNLFFAKQPEWREIRTRLSPVF 142

6g2m PEMVRNILVKDFAGFSNRYSSSDPKG-------DPLGSQNIFFLKNPAWKEVRLKLSPFF 140

6g2ps PDLIKRILIKDFGKFSNRYSNSDYKG-------DPLGSQNIFFLKNPAWKEVRFKLSPFF 140

6t1m PALIKRIMVEDFAQFSSRFETTDPTC-------DTMGSQNLFFSKYETWRETHKIFAPFF 159

6t2pm PALIRRILVEDFPEFSSSFKSTDAIR-------DTMGSGNLLFTKYKTWWETHKIFA--- 147

6t1ps PALIKRILVEDFSQFSSRFETTDPIG-------DTMGAQNLFFSKHETWRETHKIFAPFF 163

6t3m PELIRQVLIKNFNNFLNRFESADAG--------DPMGALTLPLAKYHHWKESRQCMSQLF 139

6t3ps PELIRLVLIKHFNSFLNRYEAADAAG-------DPMGSLTLPLAKYHNWRESRQSMAQLF 140

9b1m PQLIKKICVKDFDHFPNHQTLNIPN--------ERLVNDMLNVMRDQHWRNMRSVLTPVF 138

9b2m PELIKKVCVKDFDHFPNHQPFITSN--------DRLFNDMLSVMRDQRWKHMRNTLTPVF 138

9B2ps PEIIKKICIKDFDHFPNHQLFLESN--------ERLLNDMLSVMRDQRWKHMRNTLTPVF 138

9f2m PDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDARWKDMRSTLSPAF 145

9f3pm PDLIKQITIKDFDHFINHRNEFDTSSDDDPHDMSNLFSSSLFSMRDARWKDMRSTLSPAF 145

9F2ps PDLLRQITIKDFDHFINHRNLFGTGTDDDPHDMSNLFGSSLFSMRDARWKDMRSTLSPAF 145

9c1m PELIRQVGIKNFDTFTNHRKGITEGFN-----DTSVISKSLLSLRDRRWKQMRSTLTPTF 142

9c1ps PELIRQVGIKSFDNFANHRKGLGDAGGG---ANDSVLSKSLLSLRDRRWKQMRSTLTPTF 144

9h1m PELIKLIGIKEFDHFVNHNS----MHNN---IQESILSKSLISLRDGRWKEMRNILTPAF 141

9h1ps PDLIKLVGIKEFDHFVNHHS----MHNN---VQESILSKSLISLKDARWREMRYILTPAF 141

6d2m AQLARQIMTSDFASFHDRGVYVDED--------KDPLSANLFNLRGASWRNLRQKLTPSF 134

6d2ps AQLARQIMTSDFASFHDRGVYVDEK--------NDPLSANLFNLRGASWRNLRKKMTPSF 135

6d4m ADLARRVLAQDFASFHDRGVYVDEE--------RDPLSANIFSLRGQSWRSMRHMLSPCF 136

6d4ps AALARRVLAQDFASFHDRGVYVDEV--------NDPLSGSIFALRGQSWRSMRHKLSPCF 136

6d5m AQLAHDVLVKDFASFHDRGVYVDEK--------NDPMSASLFQMEGASWRALRNKLTPSF 134

6D5ps PQLAHDILVKDFASFHDRGIYVDEK--------NDPMSATIFAMEGSNWRNLRAKLTPSF 134

310a1m VELAQTILQQSNGHFSELKWDY---------------------ISGYRRFNLLEKLAPMF 120

310a1ps VELAQTILQQSNGHFNDLKWDY---------------------VKGYRRFNLLEKLSPIF 120

28a5m PALARRVFVSNFKNFHDNEIAKNIDEKT-----DFIFANNPFSLTGEKWKTRRADVTPGL 141

28A5ps PELARRVFVSDFKHFHDNEVSNLIDEKS-----DFIFANNPFSLTGDKWKQRRADVTPGL 141

28d1m PEYAHKIYVSDFRSFHDNEMAKFTDSKT-----DPILANNPFVLTGEAWKERRAEVTPGL 143

28d1ps PEYAHKIFAGEFRSFHDNEIGKFTNKKV-----DKILANNPFILTGEDWKERRAEITPGL 143

28d2m PEYIHKIYATDFRSFHNNEWRNFVNKKT-----DMILGNNPFVLTGDEWKERRSEIMPAL 143

28c1m PRLVYEIYVSAFSHFENNDASKMVDIAK-----DRLVALNPFVLEGEEWRHQRAVFSTLL 141

28c1ps PRLVYEVFVSAFRHFEDNDAARMVDTGK-----DVLVCCNPFVLEGNEWRQQRGIFSSLL 141

309a1m PALAHEILVDKFSHFRDTITSSFVGHNPD----DKYVAGSPFFSAGDKWKRLRSENVGGL 146

309a1ps PALAHEVLVDKFSHFRDTVTSSFVGHNPD----DRFVQVSPFFSAGDDWKRRRTESGGGI 146

309a2m PELAHEVLVSNFRCYKDSLQSSYLRHAKW----DKYARLNPFWASGQSWRRLRTDAQAGI 145

309a2ps PELAHEILVLNFRCYKDSLTSSYIRHARW----DKYARRNPFWASGQSWRSLRTDAQAGI 145

308a1m QELLRQILVG--RNFADCADNAVYVDHQR----DVLASHNPFIANGDRWRVLRADLVPLF 137

308a1ps QRLVREVLVG--SSFLNCADNAVNVDAQR----DVLATCNPFIASGDRWRILRADLVPLF 143

4aa1m PEDLQVILSSKKHTNKVF-FYRLMH---------NFLGDGLITSSGSKWSNHRRLIQPAF 152

4aa1ps PEDLQVILSSQKHTNKVF-IYQLMH---------NFLGDGLITSSGLKWSTHRRLIQPAF 163

4C3m PETVEPILNSQKFVNKSH-DYDYLH---------PWLGEGLLTSTDRKWHSRRKILTPAF 162

4C3ps PETVEPILNSQKFVNKSH-DYDYLH---------PWLGTGLLTSTDRKWHSRRKILTPAF 162

4d1m PKDVEVVLGTLRFNDKAG-EYKALE---------PWLKEGLLVSRGRKWHKRRKIITPAF 138

4D1ps PKDVEVVLGTMRFNDKAG-EYKALE---------PWLKEGLLVSRGRKWHKRRKIITPAF 138

4d1malt PRDVERVLGSSQLLTKSQ-EYSFLG---------RWLNEGLLVSNGRKWHRRRKIITPAF 130

4D1psalt PSDVEQVLSSTQLVDKAD-EYDFLA---------RWLNEGLLVSTGRKWHKRRKIITPAF 140

4s3m PEDIKQLLGNNQLLTKSR-NYELLE---------PWLGKGLLTNGGESWHRRRKLLTPGF 131

4s3ps PEDIRQLLGNNSLLYKSR-NYALLE---------PWLGKGLLTNGGESWHRRRKLLTPGF 131

312a1m PKDIQALCSAQQLLQKTN-DYRVFE---------NWLCEGLFTSGFEKWSHRRKIVMPAF 138

312a1ps PKDIQALCSAQQMLQKTT-DYKVFE---------NWLCEGLFTADYDKWFQRRKTLTPAF 139

4g1m PSDIELILSGHQHLTKAE-EYRYFK---------PWFGDGLLISNGHHWRHHRKMIAPTF 159

4G1ps PNDIELILSGHQHLTKAE-EYRYFK---------PWFGDGLLISNGHHWRHHRKMIAPTF 157

4g15m PRDVELLLSSHVYIDKAS-EYKFFK---------PWLGDGLLISTGQKWRSHRKLIAPTF 147

4G15ps PRDVELLLSSHVYIDKAS-EYKFFK---------PWLGDGLLISTGQKWRSHRKLIAPTF 147

4d2m PRDIEFVLSSQQHITKNN-LYKLLN---------CWLGDGLLMSTGRKWHGRRKIITPTF 133

4D2ps PHDIEFILSSQQHITKNN-LYELLH---------CWLGTGLLMSTGKKWHSRRKIITPTF 134

4d14m SKMIEAIMSSQQTIQKNN-LYSLLV---------NWLGDGLLISQGKKWFRRRKIITPAF 135

4d14ps PKMIEAIMSSQQTIQKNN-LYGLLV---------NWLGDGLLLSKGKKWFRRRKIITPAF 135

4d8m AELNEQLLSSQEHLVKHP-VYKVLG---------QWLGNGLLLSDGKVWHQRRKIITPTF 133

4d8ps SEINEQLLSSQEHLVKHP-VYRVLG---------KWLGNGLLLSDGKVWHQRRKIITPTF 133

4ae1m PRHIDALLQGQHQLKKGT-MYFALR---------GWLGDGLLLSRGKEWHTMRKIITPTF 136

4AE1ps PSHVDALLHSQKQLRKSS-IYGALR---------GWLGNGLLLSQGEQWHGMRKIITPTF 136

4d20m LQYFETILSSTTLLEKGQ-LYEYLR---------PFLNDGLLVSTGRKWHARRKIFTHAF 135

4D20ps LKYFEAILGSTTLLQKGQ-LYKFLR---------PFLNDGLLLSVGKKWHARRKVFTNAF 136

4d21m LKYFESILSSSTLLKKAH-LYRFLR---------DFLGDGLLLSTGNKWTSRRKVLAPAF 135

4e2m SKYLEFILSSQTLITKSD-IYQLTH---------PWLGLGLLTSTGSKWHKHRKMITPAF 135

4e2ps HKYLEFILSSQTLITKSD-IYNLTH---------PWLGLGLLTSTGSKWHKHRKMITPSF 135

4e1m PKYMEFILSSQTLISKSD-VYDLTH---------PWLGLGLLTSTGSKWHKHRKMITPAF 135

4e1ps TKYFEFILSSQTLISKAE-VYSLMQ---------PWLGLGLLTSTGSKWHKHRKMITPSF 135

4e3m PKQLEYILNSQQLIQKST-IYDLLH---------PWLGHGLLTSFGSKWHKHRKMITPSF 135

4e3ps PKYLEYILNSQSLIQKST-IYELLH---------PWLGYGLLTSHGSKWHKHRKMITPSF 135

4ad1m PAEIQNILSSSSLLYKEH-LYSFLR---------PWLGDGLLTSSGARWLKHQKLYAPAF 137

4AD1ps PAEIQNILSSSSLLYKEH-LYSFLR---------PWLGDGLLTSSGARWLKHQKLYMPAF 137

4p1m DSAENVLN-HPNLITKGL-VYNFLH---------PFLRTGLLTSTGKKWHARRKMLTPTF 148

4p3m DSAERVLN-DPNLINKGT-IYDFLH---------PFLRTGLLTSTGKKWHARRKMLSPTF 148

4p1ps ENAENILN-HPKLITKSL-VYDFLQ---------PALRTGLLTSTEKKWHARRKMLTPTF 148

4P2ps HNAANILN-HPNLITKGV-IYNFLH---------PFLRTGVLTATEKKWHARRKMLTRTF 150

4P3ps ETAEMILTDQKSLIGKGC-VYNFLH---------PALKTGLLTSQGDKWHARRRMLTPTF 149

4p2m HNAANILN-HPNLITKGV-IYNFLH---------PFLRTGVLTATEKKWHTRRSMLTRTF 150

4ac1m EEAEEVFQ-STKLITKNV-VYELIR---------PFLGDGLLISTDHKWHSRRKALTPAF 150

4AC1ps EEAEEIFQ-STKLITKNV-IYELLR---------PFLGEGLLISTDQKWHSRRKALTPAF 150

4ac2ps EEAEEIFQ-STKLLTKNV-VYDLLR---------PFLGEGLLTSTDQKWHARRKALTPAF 150

4ac2m EEAEEILQ-SSKLITKNM-IYELLK---------PFLGEGLLISTDQKWHSRRKALTPAF 151

4ac3m EDAEEIFQ-STKITTKNM-SYELIR---------PFLGDGLLISIDQKWHTRRKTLTPAF 150

311a1m AEETRQALHDP-TLRKAD-TFMQLE---------PLIGNGLLISHGAHWTRQRRLLTPAF 130

311a1ps AEETREALHDP-TLRKAK-TFLQLE---------PLIGNGLLISHGSHWTQQRRLLTPAF 79

316a1m LELSRQLLENDTHLETG---YELMK---------DWLVGGVLMCQSEQWQKRHSLISGLF 131

316A1ps LELAKQVLQSEQHLETG---YELMR---------HWLGGGVLMCDKNQWTQRHGLIGSIF 131

313a2m PKIAEKVLTSPFCINRSSQTTNALA---------LSMGYGLLTLQGSKWMARRKHMNPAF 134

313a3m PKIAEEIFLSPECLNRSSIFSKPVN---------SCTGDGLLSLEASKWVDRRKNLNPAF 134

313a1m PKVVEDIFSSPDCHNKSQHIVNAIT---------SCMGNGLLGKQDPHWLDRRKHFNPSF 134

313C1ps PNVVQDVLTSPHCLDKSKIACNPLR---------LICGPATFALNGSHWVERRKQMNPSF 133

313C2ps PNVIQDILTSPHCLDKSQTACNAII---------MNSGPGILALRGSHWVERRRKMIPSF 133

313a5m PKILEDIFTSPNCSNRSSVVDKAIS---------SCLGLGLLTLKNNHWNERRKLLLPSF 133

313a4m PQVVQDIFTSPHCVNKG-IIYKAVD---------DGAGVGLFSLKDPRWSIHRKLLNPAF 132

313a4ps PQVVQDILTSPHCVNKG-IIYKAVD---------DGAGVGLFSLKDPRWSVHRKLLNPAF 132

313A4bps PQVVQDILTSPHCVNKG-IIYRAVD---------DGMGVGLFSLKDPRWSVHRKLLNPAF 132

313b1m PHSVEQILNSTHCTNKG-DFYRFMS---------SAIGDGLFTSSSPRWHKHRRLINPAF 132

313b1ps PQTVEQVFNSNHCTNKG-DFYRFLS---------SAIGDGLFTFSAPRWHKHRRLINPAF 134

318a1m PAGMECVLNAPECLDKT---FLQDG---------FFVRRGLLHARGQKWKLRRKQLNPAF 134

318A1ps PAGMESILNAPECLDKT---FMQEG---------FFAKRGLLHARGQKWKLRRKQLNPAF 134

18a1m YKMIRECFRR--EEFTGRPDTPFMQTLNG---------YGIINSTGKLWKDQRRFLHDKL 151

18a1ps YKMIRECFRR--EEFTGRPDTPFMQTLNG---------YGIINSTGKLWKDQRRFLHDKL 152

306A1m AALVRDFFRR--DVMTGRAPLYLTHGIMGG--------FGIICAQEDIWRHARRETIDWL 148

306A1ps VTLVREFFRH--EVMAARAPLYLTHGIMGG--------YGIICAAGPIWKHQRRELIDWL 153

303a1m NDAISEMMTN--EDIDGRPDGIFYRLRTFN------SRLGVLLTDGEMWVEQRRFILRHL 137

303A1ps NDAISEMMTN--EDIDGRPDGIFYRLRTFN------SRLGVLLTDGEMWVEQRRFILRHL 137

305a1m HEMVKEVQLQ--EVFEGRPDNFFLRLRTMG------TRKGITCTDGQLWYEHRHFAMKQM 137

305A1ps HEMVREVQLQ--EVFEGRPDNFFLRLRTMG------TRKGITFTDGKLWYEHRNFAMKQM 137

304a1m ADGVREILNN--QVFDGRPQLFVAAMRDPGQ-----DVRGIFFQDGPLWKEQRRFILRYL 136

304a1ps GEGVREVLNN--QVFDGRPGIFLAAMRDPGD-----DVRGIFFQEGALWKEQRRFILRYL 136

307a1m LELIREVLNQNGKVMSGRPDFIRYHKLFGG--------ERSNSLALCDWSQLQQKRRNLA 158

307a1ps LELIREVLNQNGKVVSGRPDFLRYHKLFGG--------ERSNSLALCDWSQLQQKRRNMA 153

307a2pm VDLIKEVLNKNGKYFGGRPDFFRYHKLFGG--------DRNN------------------ 136

307a2pps LDLIREVLNKNGKFIGGRPDFIRYHKLFGG--------DRNNSLALCDWSNLQQKRRNLA 154

5C

5A 5B 5D 5E 5F 5G

12a4m MQPKNVRLYYKKMSQVNQEFVQRILELRDPD----------TLEAPDDFID 206

12a5m MQPKNVRLYFKKMSQVNQEFVELIKEIRDAS----------TQEVPGNFLE 206

12A4ps MQPKNVRLYYKKMSQVNQEFVQRIKTLRDVD----------TQEVPDDFIS 205

12A5ps MQPKNVRLYYKKMSQVNQEFVQRIKALRDID----------TQEAPDDFLT 205

12c1m MQHRNVAIYLKPMQRVNRQFVNRIREIRDKE----------SQEVPGDFMN 198

12c1ps MQHRNANLYLEPMQRVNNQFIDRIRATRDKE----------SLEMPGDFLD 208

12e1m LQPRNAKLYMTNLVQVSDEFLERIRIIRDPV----------TQEMPDDFAV 188

12e1ps LQPRNAKLYLKNLVQVSDEFLERIRLIRDPV----------SQEMPDDFTE 190

12d1m MQPRGLRMYYEPLSNINNEFIERIKEIRDPK----------TLEVPEDFTD 200

12d1ps MQPRGLRMYFEPLSNINNEFIERIKEIRDPS----------TLEVPSNFND 200

12b2m MKVQNVRQNLPQLDQISKEFIDKLETQRNPE----------THTLTTDFHN 211

12B2ps MKVQNVRQNLPQLDQIAKEFIDKLESQRDPE----------THLLQDDFHD 214

49A1m LQPQTAKKYIPPLNDIASEFMGRIELMRD-E----------KDELPANFLH 261

49A1ps LQPQTAKKYIPPLNDIASEFMGRIEAMRD-E----------KDELPANFLH 266

301a1m LQLSTIRRYLQPLEVITEDFLVRCENLLD-E----------NQELPEDFDN 233

301A1ps LQLSTIRRYLQPLEAITDDFLVRCEHLLD-G----------NQELPKDFDN 238

302a1m SAPKSVRNFVRQVDGVTKEFIRFLQESRNGG----------AIDMLPKLTR 179

302A1ps SAPKSVRNFIPQVDGVTREFLTFLRESSDDGD---------AIDMLPKLTR 180

314a1m TSPRVLQNFLPALNAVCDDFIELLRARRDPD-----------TLVVPNFEE 217

314a1ps TSPRVLQNFLPALNAVCDDFIDLLRARRDPD-----------TLVVPNFEE 218

315a1m LNGNLNWMDVHIESCTRRMVDQWKRRTAEAAAIPLAESGEIRSYELPLLEQ 219

315a1ps LNGNLNWMDVHIESCTRQLVDQWRARTEEATAECDVP-GSPSYYELPNLEQ 212

6a2m TSGKMK-FMFPTVIKVSEEFVKVITEQVPAAQN----------GAVLEIKE 177

6a2ps TSGKMK-LMFPTVIKVSEEFASVMEEQVPPTQG----------GAIIEIKE 177

6a8m TSGKMK-LMYPTVVSVANEFMTVMHEKVPKNS-------------VLEIRD 177

6a18m TSGKMK-FMYPTVVSVAEEFMAVMHEKVSENS-------------ILDVRD 177

6a8ps TAGKMK-FMYPTVVSVAEEFIDVMHEKMKQNS-------------VLEIRE 177

6a9m TSGKMK-YMFPTVVKVGHEFIEVFGQAMEKSP-------------IVEVRD 176

6a21m TSGKMK-YMFPTVVKVANEFTDVFGQNVAKSP-------------VVEVRE 176

6a21ps TSGKMK-YMFPTVVKVSHEFTEVFGQMADKSP-------------IVEVRE 178

6a17m TSGKMK-NMFPIVVKVGEEMDKVFRSKTAADR-----------GQVLEVVD 175

6a23m TSGKMK-NMFPIIVKVGEEMEKIFSAKTTTGE-----------GQVLEIVD 176

6A17ps TSGKMK-HMFPIVVKVGEEMDKVFSNKVGD-------------GKVLEIVD 174

6A23ps TSGKMK-HMFPIVVKVGEEMDKVFSNKVGD-------------GKVLEIVD 173

6a20ps TSGKMK-IMFPTVLEIGNEMIRVFAEKIGPQ------------P--LNVAD 174

6a20m TSGKMK-TMFPTILTVGDELIRVFGETASAD------------SDSMEITN 186

6a19m TSAKMK-SMFSTVLNVGDEMIRVVDEKISSS------------SQTLEVTD 176

6a22m TSAKMK-YMFPTVCEVGEELTQVCGELADNAM-----------CGILEIGD 176

6A22ps TSGKMK-FMFPTICEVGVDLAEVCGELAANAI-----------CGILEISD 176

6a13m TSGKMK-FMFPNMVEVG-------EKLTQACRLQ---------VGEIEAKD 170

6A13ps TSGKMK-FMFPTMLSVG-------EKLTQACELQ---------VGEIEAKD 170

6a14m TSGKIK-QMSKVIVDVGLRLGDAMDKAVKEAKVE---------EGNVEIKD 187

6A14ps TSGKIK-HMSGVVVEVGHRLAAAMDKAVSAAKVD---------DGDVEIKD 168

6a15pm ---------------------------------------------------

6a16m TSGKMK-YMFGTVSTVAQQLGGTFDELVGSQG------------AVLELHD 170

6A16ps SSGNVK-CIFGTITEVARNLEESFQELVGTQG------------GVLDVHD 170

6u1m TPANMQ-KLLVRLSQISS----RIQRDLGEKS-----------LQTINISE 172

6u1ps TPANIN-KLLPRIVLISR----GVQRSLGKER-----------LQTLNINE 175

317a1m EGDRMS-LLYDCLYEEAEQLLLTVNSTLMSQP-----------HSTVHIQK 184

317a1ps ESDRMS-WLFGSLYEEAEQLLLTVTSTLMKQP-----------HSTLHIQK 184

6g1m TSGKVK-QMYTLMQEIGKDLELALQRRGEKNS----------GSFITEIKE 181

6G1ps TSGKVK-QMYTLMLEIAHDLEEHLKKHVQNNSNS--------GKYITEIKE 183

6w1m TSGKIK-QMYPLMVKIGKNLQDSAERLGSGT--------------EVQVKD 174

6w1ps TTGKIK-QMYPLMVKIGKNLEANVGREPKDS--------------IVTIKS 176

6v1m AGAKLK-QMFSLMEEIGCDLEWYLKRLTRDLRRGDA----ERG-AIVSIKD 187

6v1ps TGAKIK-QMFSLMEEIGCDLEYYLKRLTRDMRRSDA----SARGVIVSIKD 188

6g2m TGNRLK-QMFPLIEEVGASLDAHLRQQPLHNER--------MRCFDLEAKE 182

6g2ps TSNKLK-SMFPLIVEVGSNLDAYLREQPLHNER--------TRCFDLEAKE 182

6t1m AAGKV-RNMYGLLENIGQKLEEHMEQKLSGRDS-----------MELEVKQ 198

6t2pm --------LYGLLERIQNLEAHMKKKKLNGAES-----------VELEVKQ 179

6t1ps AVSKV-RQMYGLLEHIGQQLEEHMEDQLNGKSE-----------IELEVKQ 202

6t3m TSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLE-----------RVLPLGR 179

6t3ps TSGRMRESMYPLMMGVVIDLEQYLQRKLGDRSE-----------RMLPLSK 180

9b1m TSAKMR-NMFTLMNESFAQCLEHLKSSQPIA-A-------GENAFELDMKV 180

9b2m TAAKMR-NMFTLMNESFAECLQHLDSSSKTL-P-------GRKGFEVDMKV 180

9B2ps TAAKMR-SMFALMNDSFGECLEHLSRLSDGS-K-------SGEGLEVDMKV 180

9f2m TGSKMR-QMFQLMNQVAKEAVDCLKQDDS-----------RVQENELDMKD 184

9f3pm TGSKMR-QMFQLMNQVAKEAVDCLKQDDS-----------RVQENELDMKD 184

9F2ps TGLKMR-QMFQLMNQVAKEAVDCLKPDQQG----------SVQGTELDMKD 185

9c1m TSLKIR-QMFELIHFCNVEAVDFVQRQLDAG------------TSELELKD 180

9c1ps TSLKIR-LMFELIQVCNVEAVAYIERKLAEDG-----------ATELELKD 183

9h1m TGSKMR-IMYDLIQSCSEEGVIHIQEQLELSQ---------DASIELEMKD 182

9h1ps TGTKMR-VMYQLIQSCSEEAVRHIGEQLAQSN---------TGAIELEMKD 182

6d2m SSGKIK-GMFGTIDDVGDKLVQHLEGALDQS-------------DEVEIKD 171

6d2ps SSGKIK-GMFGTIDDVGDKMVQHLKGVLERAGAD----------NEIDIKE 175

6d4m TSGKLK-SMFSTSEDIGDKMVAHLQKELPEEGF-----------KEVDIKK 175

6d4ps TSGKLK-GMFSTSEEIANNMVNHLQKTLPEQGS-----------QEVDLKT 175

6d5m TSGKLK-AMFETSDSVGDKLVDSIRKQLPANGA-----------KELELKK 173

6D5ps TSGKLK-AMFSTSEAIGDKMVAHLNGKLPKEGS-----------QEIEMKE 173

310a1m GTKRLS-EMFGQVQKVGDHLIHHLLDRQ-GQGCP----------QEVDIQQ 159

310a1ps ATKRLS-EMFTHVQRVGDHLISYLLDIEQAQGGA----------LELDLQQ 160

28a5m TMGRIK-TVYPVTNKVCQKLTEWVEKQLRLGSK----------DGIDA-KH 180

28A5ps TMGRIK-TVYPVTNKVCQKLSEWVDKQIRLGAP----------EGINA-KD 180

28d1m SANRVK-AAYPVSLRVCKKFVEYIRRQSLMAPA----------QGLNA-KD 182

28d1ps SANRVK-AVYPVSQSVCKHFVEYIKRQQRMATS----------DGINA-KD 182

28d2m SPNRVK-AVYPVSQSVCKKFVEYIRRQQQMATS----------EGLDA-MD 182

28c1m TNGRIR-TTHAIMQRVCLDLCQFIAIKSAGG------------KDLDC-ID 178

28c1ps TNGRIR-TTHTIMQRVCRDLCDFIAKESLKG------------EPQDG-MD 178

309a1m TPSRLK-MAYSIWEQSGRKLVEYIERARREQGD----------IIETR--D 184

309a1ps TPNKLK-MAFTIWEQSGKKLLEYIERVRQERGD----------IIETR--D 184

309a2m SGSRLR-QAYNIWEQGGQMLTEYMTQQVAEKNN----------ILETR--D 183

309a2ps SGHRLK-QGYAIWEEGGRMLTSYMTDRIKAPHN----------LLETR--D 183

308a1m TPSRVR-QTLPHVARACQLLRDQVP------------------LGRFEAKD 169

308a1ps TPSRLR-QTLPHVAAACQQLQEFVGRRLT--------------GERFEAKA 179

4aa1m HHNLLEKFIDTFVDASQSLYENLDAEAVG---------------TEINIAK 188

4aa1ps HLSLLEKFIGTFVDASQSLYESVGASAVG---------------TDINIVS 199

4C3m HFKILDDFIDVFNEQSAVLARKLAVEVGS---------------EAFNLFP 198

4C3ps HFKILDDFVDVFNEQSAVLARKLAVEVGS---------------EAFNLFP 198

4d1m HFKILDQFVEVFEKGSRDLLRNMEQDRLKHG------------DSGFSLYD 177

4D1ps HFKILDQFVDVFENGSRDLLRNMEMDRLRQG------------QTGFNLYD 177

4d1malt HFRILEPYVEIFDRQSLRLVEELALRISR-G------------QERINLGE 168

4D1psalt HFRILEQYVEIFDRQTHQFLSNLDLARGK-D------------DNLVNLGH 178

4s3m HFRILSEFKEPMEENCRILVRRLRTKANG---------------ESFDIYP 167

4s3ps HFRILSEFKEPMEENCRILVSQLKERANG---------------EAFDIYP 167

312a1m NYTMIKQFVAVFEKQSRILLTNVAKFAES--------------GDQIDFLQ 175

312a1ps NYTMIKQFVQVFERQSRILLPRVAEYAES--------------GKSVDFLD 176

4g1m HQSILKSFVPTFVDHSKAVVARMGLEAGK----------------SFDVHD 194

4G1ps HQSILKSFVPTFVDHSKSVVGRMGLETGK----------------SFDVHD 192

4g15m HLNVLKSFIELFNENSRNVVRKLRAEDGR----------------TFDCHD 182

4G15ps HLNVLKSFIELFNENSRNVVRKLRAEDGR----------------TFDCHD 182

4d2m HFKILEQFVEIFDQQSAVMVEQLQSRADG--------------MTPINIFP 170

4D2ps HFKILEQFVEIFDQQSAVMVGQLQQRADG--------------KTAINIFS 171

4d14m HFKILEDFVEVFDQQSATMVQKLYDRADG--------------KTVINMFP 172

4d14ps HFKILEQFVEVFDQQSAIMAKNLYDRADG--------------KTVINMFP 172

4d8m HFSILEQFVEVFDQQSNICVQRLAQKAN---------------GNTFDVYR 169

4d8ps HFSILEQFVEVFDQQSNVCVERLAPRAN---------------GQTFDVYR 169

4ae1m HFSILEQFVEVFDRQSSILVERLRTLSYG--------------NEVVNIYP 173

4AE1ps HFSILEEFVEVFDKQSQLLVERLQPLSNGG-------------MVAINIYP 174

4d20m HFKVLEHYVEIMDRHSSVMVDNLRKVADG--------------KTAVDMLK 172

4D20ps HFNVLGHYVDIMDRQAAVMVEKLRQVADG--------------ETTVDMLP 173

4d21m HFKCLENFVEIMDRNSGIMVEKLKNYADG--------------KTCVDLFK 172

4e2m HFNILQDFHEVMNENSTKFIKHLKTVAAG--------------DNIFDFQE 172

4e2ps HFNILQDFHEVMNENSTKFIKQLKQVAAG--------------DSIFDFQN 172

4e1m HFNILQDFHEVMNENSTKFIDQLKKVADG--------------GNIFDFQE 172

4e1ps HFNVLQDFHEVMNEKSTKFIKHLKNVSGG--------------GSIVDFQE 172

4e3m HFNILQDFHEVMNENSAKFMTQLKKASAG--------------DTIIDFQE 172

4e3ps HFNILQDFHEVMNENSTKFIAQLRRDAAG--------------DSIIDFQD 172

4ad1m ERSAIEGYLRVVHRTGGQFVQKLDVLSDT--------------QEVFDAQE 174

4AD1ps ERSAIEGYLRVVHRTGGKFVQKLNELTET--------------LEVFDAQE 174

4p1m HFNILNQFQEIFKTESQKFLLQFEGQDEV---------------TITLH-D 183

4p3m HFNILNQFQEIFITESLKFLEQFKGNDEA---------------IISLN-E 183

4p1ps HFNILGQFQEIFRAESLKFVQQFQSQDES---------------IVSLS-D 183

4P2ps HFNILEQFQEIFQAESLKFVQQFQSQDES---------------IVSLS-D 185

4P3ps HFNILGQFQEIFQAESLKFVQQFQSQDEN---------------IVSLS-E 184

4p2m HLDILNQFQEIFIAESLKFVSQFQGQNEV---------------VVSLK-D 185

4ac1m HFNVLQSFLGIFKEECKKFLNVLEKNLDA---------------ELELN-Q 185

4AC1ps HFNVLQSFLAIFKEECNKLIKVLDKKVDG---------------ELDLN-Q 185

4ac2ps HFNVLQSFLAIFKEECHKLVKVLHESVES---------------EALVLNQ 186

4ac2m HFKVLQSFLIIFKEECNKLVKVLHQSVNM---------------ELELN-Q 186

4ac3m HFNILQSFLSIFKEESKKFIKILDKNVGF---------------ELELN-Q 185

311a1m QPQLLRSFAPAIGGHVERLVGRLGATRG----------------AFLEVTE 165

311a1ps RPTLLRSFAPSVAKHADRLIQRLEETRG----------------SFLEVTD 114

316a1m DKGNLEQLIDLSRHQTEQLLQKLAKQADQK---------------VFDIWY 167

316A1ps NKGNMLPLTELCRQQAVLLQLTLADHAEQRD--------------VFDAWT 168

313a2m KHSVLLSFLPIFNAETDLLVSVFDSFVGQG---------------EKDVLS 170

313a3m KQNVLLSFLPIFNSEAKTLVAFLDSLVGQG---------------EKKVRD 170

313a1m KQDLLLSFFHIFDAETKVLMNLLDTYVDKG---------------EIDVVP 170

313C1ps RHNVLMSFFPLFNEETKNLISLLETFVGQG---------------EKKLLP 169

313C2ps KKNVVMSFLPIFNEETNSLLSVLDTFVGQG---------------EREILP 169

313a5m KNNAVLSFVPVLNNEANFLVTLLAEFVDGG---------------DINLLP 169

313a4m GHKVLLSFLPIFNRETALLLDQLEPLQDDG---------------EKDLIP 168

313a4ps GHKVLLSFLPIFNKETAQLLSQLDALPGGG---------------EKDLIP 168

313A4bps SHKVLLSFLPIFNKETGQLLSQFDDLPSKG---------------EYNLIP 168

313b1m GRQILSNFLPIFNAEAEVLLQKLELEGVQHG-------------KRLEIYQ 170

313b1ps GRQILCNFLPIFNAEAEVLLLKLDLEGVQHG-------------KELEIYQ 172

318a1m SHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQA----------VKFTAAED 175

318A1ps SHNIVASFFDVFNAVGNQMVEQFASQPHLHGRA----------VKFTDAED 175

18a1m RQFGMTYMGN--------GKQQMQKRIMTEVHEFIG-HLHASDGQPVDMSP 193

18a1ps RQFGMTYMGN--------GKQQMQKRIMTEVHEFIG-HLHASDGQPIDLSP 194

306A1m KALGMTRRPGELRARLERRIARGVDECVRLFDT----EAKKSCASEVNPLP 195

306A1ps KALGMTRRPGETRSRLEQRIGRGVDECVQLYET----DADVSPSSEFDPVP 200

303a1m KNFGFAR--SGMMDIVHNEATCLLQDLKDKVLK------SGGKQTRIEMHD 180

303A1ps KNFGFAR--SGMTDIVHNEATCLLQDLRAVVRR------EGGHQARIQMHD 180

305a1m RNVGYGR--SQMEHHIELEAEELLGQLERTE------------EQPIEPVT 174

305A1ps RHVGYGR--SQMESHIEREAEELLLQLGRTE------------EAPIEPVT 174

304a1m RDFGFGRRFDQLELVIQEQLNDMLDLIRNGPKYPHEHEMVKSGGYRVLLPL 187

304a1ps RDFGFGRRFDELELVIKEQITDMLDMIRNGPKYPHEHHLVKPGGYRVQLPL 187

307a1m RRHCSPREFSCFYMKMSQIGCEEMEHWNRELGN------QLVPGEPINIKP 203

307a1ps RRHCSPRESSSFYMQMSQIGCEEMEHFIREIDA------KMVPGEPFDVKT 198

307a2pm ---------------------------------------------------

307a2pps RRHCSPRESSPYFNKMSHIGCNEINHLMREL-N------KTQPGKPFDIKK 198

6A 6B 6C 6D 6E

12a4m TINRWTLESVSVVALDKQLGLLKNS--NKESEALKLFHYLDEFFIVSIDLEMKPSPWRYI 264

12a5m TINRWTLESVSVVALDKQLGLLRES--GKNSEATKLFKYLDEFFLHSADLEMKPSLWRYF 264

12A4ps IINRWTLESVSVVALDKQLGLLKES--GDNDLAVLLFKHLDDFFELSADLEIKPSIWRYV 263

12A5ps VINRWTLESVSVVALDKQLGLLKES--DDNDQAVLLFKYLDDFFELTADLEMKPSIWRYF 263

12c1m TINHLTFESVATVALDRELGLLREA--NPPPEASKLFKNIEVLMDSFFDLGVRPSLYRYI 256

12c1ps TINTLTFESVAVVALDRELGLLRDS--DQKPEAKELFRNIKIFLQSFFDLGIKPSVYKYI 266

12e1m DIRHLVIESICSVALNTHLGLLGEQ--RNNKDIQKLVLALQDVVELGFQLDIMPAFWKYL 246

12e1ps DIRNLVIESIGSVALNTHLGLLGEN--RYSDEANQLKAAMRDFVELGFQLDMMPAIWKYL 248

12d1m EISRLVFESLGLVAFDRQMGLIRKN--RDNSDALTLFQTSRDIFRLTFKLDIQPSMWKII 258

12d1ps EMQRLIFESLALVSFDRQMGIIRKH--RDNPDALALFRTSRDIFRYTFQLDVQPSAWKIV 258

12b2m QLKMWAFESISFVALNTRMGLLSDN---PDPNADRLAKHMRDFFNYSFQFDVQPSIWTFY 268

12B2ps QLKNWAFESISFVALNTRMGLLSDQ---PDPNAARLAKHMSDFVNYSFQYDVLPSIWPYY 271

49A1m ELYKWALESVGRVSLDTRLGCLSP--E-GSEEAQQIIEAINTFFWAVPELELRMPLWRIY 318

49A1ps ELYKWALESVGRVSLDTRLGCLSP--E-GSEEAQQIIDAINTFFWAVPELELRMPLWRIY 323

301a1m EIHKWSLECIGRVALDTRLGCLESNLK-PDSEPQQIIDAAKYALRNVATLELKAPYWRYF 292

301A1ps EIHKWSLECIGRVALDTRLGCLEANLS-PDSEPQQIIDAAKYALRNVATLELKAPYWRYF 297

302a1m LN----LELTCLLTFGARLQSFTAQEQDPRSRSTRLMDAAETTNSCILPTDQGLQLWRFL 235

302A1ps LN----LELTCLLTFGARLQSFSPEEQSPQSRSTHLMHAAETTNSCILPTDQGLQLWRLM 236

314a1m LANLMGLEAVCTLMLGRRMGFLAIDTKQPQ-KISQLAAAVKQLFISQRDSYYGLGLWKYF 276

314a1ps LANLMGLEAVCTLMLGRRMGFLAADAKQPQ-KISQLAAAVKQLFISQRDSYYGLGLWKYF 277

315a1m QLYRWSIEVLCCIMFGTSVLTCPK---IQSSLDYFTQIVHKVFEHSSRLMTFPPRLAQIL 276

315a1ps QLYRWSIEVLCCIMFGSNVLTCPK---IQSALDHFTQIVHKVFEHSSRLMTFPPRLAQLL 269

6a2m LMARFTTDVIGTCAFGIECNT-LRT------PVSDFRTMGQKVFTDMRHG-KLLTMFVFS 229

6a2ps MMARFTTDVIGTCAFGIECNT-LRT------PVTDFRTMGQKAFTELRHG-QLLTFFIFS 229

6a8m LVARFTVDVIGTCAFGIQCNS-LRD------EKAEFLYFGKRSLVDKRHG-TLLNGFMRS 229

6a18m LVARFTVDVIGTCAFGIKCNS-LRD------EKAEFLHFGRRALLDSRHG-NLVSGLMRS 229

6a8ps LMARFTVDVIGTCAFGIKCNS-LRD------ENAEFLRFGKRTFVDKRHG-SFLTGFMTS 229

6a9m ILARFTTDVIGTCAFGIECSS-LKD------PEAEFRVMGRRAIFEQRHG-PIGIAFINS 228

6a21m LLARFTTDVIGTCAFGIECSS-LKD------PDAEFREMGRRSLTEQRLG-PVGIGFVNS 228

6a21ps LLARFTTDVIGTCAFGIDCSS-LKD------PDAEFRKMGRRALTENRHG-SLGIAFLNS 230

6a17m LVARYTADVIGNCAFGLNCNS-LYD------PKAEFVSIGKRAITEHRYG-NMLDIFLFG 227

6a23m LVARYTADVIGNCAFGLNCNS-LQN------PNAEFVTIGKRAIIERRYG-GLLDFLIFG 228

6A17ps LVARYTADVIGNCAFGLNCNS-QQN------PNADFVTFGKRALRERRYK-GLLDFFIFG 226

6A23ps LVARYTADVIGNCAFGLNCNS-QQN------PNADFVTFGKRAIGERRYW-GLLDFFIFG 225

6a20ps LVSRFSADVIGSCAFGLECNS-LRN------PNAEFVTMGKAAITERRYG-KTADLFFFG 226

6a20m VVARFTADVIGSCAFGLDCHS-LSD------PKAKFVQMGTTAITERRHG-KSMDLLLFG 238

6a19m IVSRFTSDVIGICAFGLKCNS-LRD------PKAEFVQMGYSALRERRHG-WLVDLLIFG 228

6a22m LMARYTSDVIGRCAFGVECNG-LRN------PEAEFAIMGRRAFSERRHC-KLVDGFIES 228

6A22ps IMGRYTSDVIGRCVFGLECNG-LRN------PEAQFAVMGRRAFTERRHN-QLIDGFIES 228

6a13m LCARFTTDVIGSCAFGLECNS-LQD------PESQFRRMGRSVTQEPLHS-VLVQAFMFA 222

6A13ps LCARFSTDVIGSCAFGLECNS-LND------PNSEFRRMGRSVTTNPLHT-GMVQGFMFA 222

6a14m LCARFTTDVIGSCAFGLECNS-LQD------PSAEFRQKGREIFTRRRHS-TLVQSFIFT 239

6A14ps ICARFTTDVIGTCAFGLECHS-LSD------PKAEFRSKGRMIFEKPRHS-PIVQFFVFT 220

6a15pm -------------------------------------------------------AFTVT 5

6a16m LMARYTTDVIGSCAFGTECSS-LRE------PQAEFRQVGRRIFRNSNRS-IRWRIFKMT 222

6A16ps LLDRFSMDASATCAFGIQCSS-LKD------PQVEFRVHGRKIFHHSGDG-IRWRIFKFL 222

6u1m LVGAYNTDVMASMAFGLVG-------------QDNVEFAKWTRNYWADFR-MWQAYLALE 218

6u1ps LVDSYNLDVVASMAFGLS--------------ADRTEFRRWTQSYWGKFS-LWRAYLALE 220

317a1m IMRRYVLSSLAKCVFGLNAEQRKTY------PLEDFEQMTELALNSHKHG-YLMNLMMIR 237

317a1ps LMRRYVLSALAKCVFGLDAQQRLKY------SLEDFEKMTEMAVSSHKHG-YLMNLMMIR 237

6g1m ICAQFSTDSIATIAFGIRANS-LEN------PNAEFRNYGRKMFTFTVAR-AKDFFVAFF 233

6G1ps VCAQFSTDSIATIAFGIRANS-LQN------PNAEFRNHGRKLFSFTLSR-AKDFFVAFF 235

6w1m LCSRFTTDLIATIAFGVEANA-LQD------AKSEFFYHNRAIFSLTLSR-GIDFAIIFM 226

6w1ps LCARFTTDLIATIAFGLDANA-LQD------PKSEFFRHNQAIFAPSVSR-AIDFAIIFM 228

6v1m VCDLYNTDMIASIAFGLRSYS-LRN------TQSEIGSHCQDLFRPNVRR-IIDLFVIFY 239

6v1ps VCDLYNTDMIASIAFGLRSYS-LRS------TQSEIGSHCQDIFRPNVRR-IIDFFVIFY 240

6g2m LCALYTTDVIATVAYGVSANS-FTD------PKCEFRRHGRSVFEFNLLR-AAEFTLVFF 234

6g2ps LCALFTTDVIASVAYGVQANS-FTQ------PNGEFRRHGRAVFEFSLKR-AAEFTLVFF 234

6t1m LCALFTTDIIASLAFGIEAHS-LQN------PEAEFRRMCIEVNDPRPKR-LLHLFTMFF 250

6t2pm LCALFTTDILQ------SLQ----N------PEAEFRPMCIEVNDPKPK----RLS---- 215

6t1ps LCALFTTDIIASLAFGLEAHS-LQK------PDAEFRRMCVEVNDPRPKR-LLHLFTMFF 254

6t3m MCQLYTTDVTGNLFYSLNVGG-LRR------GRSELITKTKELFNTNPRK-VLDFMSVFF 231

6t3ps MCQLYTTDVTGNLFYSMDVGG-LRR------GKSQLLKKTKELFDPDPRK-VLDFMSIFF 232

9b1m LCNKLSNDVIATTAFGLKVNS-FDD------PENEFHTIGKTLAFSRGLP-FLKFMMCLL 232

9b2m MCNKLSNDIIATTAFGLKVNS-YDN------PKNEFYEIGQSLVFSRGLQ-FFKFMLSTL 232

9B2ps LCNKLSNDLIATTAFGLKVNS-FES------PDNEFYQIGQSLTFSRGSQ-LFKFLLATL 232

9f2m YCTRFTNDVIASTAFGLQVNS-FKD------RENTFYQMGKKLTTFTFLQ-SMKFMLFFA 236

9f3pm YCTRFTNDVIASTAFGLQVNS-FKD------RENTFYQMGKKLTTFTFLQ-NMKFILLFA 236

9F2ps YCTRFTNDVIASTAFGLQVNS-FKE------RDNDFYSMGKKLTTFGFLQ-NLKFMLFFT 237

9c1m FFTRYTNDVIATAAFGIQVNS-FKD------PNNEFFSIGQRISEFTFWG-GLKVMLYIL 232

9c1ps FFTRYTNDVIATAAFGIQVNS-FKD------PNNEFFSIGQRISDFSLWA-VLKVMLFIL 235

9h1m YFTRFANDVIATVAFGISINS-FRR------KDNEFFRIGQAMSRISAWS-VVKAMLYAL 234

9h1ps YFTRFANDVIATVAFGLSVNS-FRR------KDNEFFRIGQALSKISVWS-IVKAVLHAL 234

6d2m VMTTYAVDIIGSVIFGLEIDS-FRN------PKNEFREISSSTSRDESLLLKIHNMSMFI 224

6d2ps MMTTYAVDIIGSVIFGLEIDS-FAN------PNNEFRAISNEEARSKSLLLKIHNMAMFI 228

6d4m VMQNYAIDIIASTIFGLDVNS-FEN------PDNKFRKLVSLARAN-NRFNAMFGMMIFL 227

6d4ps VMQTYAIDIIASTIFGLEMNS-YLT------PDNKFRNLVTIARRN-TRFTTMFGMMIFL 227

6d5m LMATYAIDIIATTIFGLDVDS-FAD------PNNEFQIISKKVNRN-NIEDIIRGTSSFL 225

6D5ps LLLTYAVDIIASTIFGLDVDS-FAD------PNNEFLSITKTINQN-TFTDILRGTTSFL 225

310a1m KLRVYSVNIIANLIYGLDINN-FEH------------------EDH-ILTSYLSHSQASI 198

310a1ps MLRVYAINVIGNLIYGLDVNN-FEQ------------------KDH-ILSSYVSAGHTSL 199

28a5m MSLCFTTEMVTDCVLGLGAESFS--------DKPTPIMSKINDLFNQPWTFVLFFILTSS 232

28A5ps MSLCFTSEMVTDCVLGLSAESFS--------DNPTPIMGHIKDLFSQSWSFLIYFVIIST 232

28d1m LCLCYTTEVISDCVLGISAQSFT--------DNPTPMVGMTKRVFEQSFGFIFYTVVANL 234

28d1ps LCLCYTTEVVSDCVLGISAQSFT--------ETPTPLVGMIKRVFEQSFGFIFYTMAANL 234

28d2m LSLCYTTEVVSDCGLGVSAQSFT--------DTPTPLLKMIKRVFNTSFEFIFYSVVTNL 234

28c1m LGLRFTGESLFDCVLGIQARTFT--------DNPLPVVRQNHEMSAENRGLAIAGAVHGL 230

28c1ps LGLRFTGDSLFDCVLGIQARCFS--------DSPLPVIRHNREMSNENPGLAIAGALNGL 230

309a1m LAYRFTANAMADFIWGIDAGSLSGKV-----GEIGDFQKTSTDWSAHAFSSMIRFNKTLV 239

309a1ps LAYRFTANTMADFIWGIDAGTLTGAV-----GETSPFQKTSTDWTINAFKSIIRFNKSLV 239

309a2m LCFRYTAHVMADFIWGIDAGTLTRPM-----EQPNKVQEMASKWTSYAFYMLTLFMATIV 238

309a2ps LCFRYTAHVMADFIWGIDAGTLSRPQ-----EHPNKVQQMASKWTSHAFYMISVFMASIV 240

308a1m LATRYTLQVVASAIFGLDAHCLGIHM--RVAHEPSRWLEWLAPLFQPSVWSLLETMSLLH 227

308a1ps LATRYTLQVIASAVFGLDAHCLCYDE---DQEKGSQWLQRLLPLFQPSAWSLLETIALLH 236

4aa1m YVNNCVLDILNEAVLGVPIKKRGQD---VAMMEDSPFRQGKIMMPARFTQPWLLLDGIYH 245

4aa1ps IVNNCVVDILNEAVLGVPIKKKGLD---LVKIDESPFRQGKLMIPTRFSHPWLLFDGIYH 256

4C3m YVTLCTLDIVCETAMGRRIYAQSN----SESEYVKAVYGIGSIVQSRQAKIWLQSDFIFS 254

4C3ps YVTLCTLDIVCETAMGRRIYAQSD----SESEYVKAVYGIGSIVQSRQSKIWLQSDLIFR 254

4d1m WINLCTMDTICETAMGVSINAQSN----ADSEYVQAVKTISMVLHKRMFNILYRFDLTYM 233

4D1ps WINLCTMDTICETAMGVSINAQTN----ADSEYVQAVKTISMVLHKRMFNIFYRFDLTYM 233

4d1malt AIHLCALDAICETAMGVSINAQSN----ADSEYVQAVKTISMVLHKRMFNILYRFDLTYM 224

4D1psalt AVHLCALDVICETAMGVSINAQTN----ADSEYVQAVKTISMVLHKRMFNIFYRFDLTYM 234

4s3m YITLFALDAICETAMGIKKHAQLQ----SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFK 223

4s3ps YITLFALDAICETAMGIKKHAQLQ----SESEYVKAVQTICRVMHKQSFSFWQRLNIFFK 223

312a1m LISCFTLDTICETALGVSVGSQSS----AKSEYLDAVKSILVIIDKRLKNIFYRNSFIFK 231

312a1ps LISCYTLDVICETALGVSVDAQSG----KRSSYLEAVREVLHVIDYRLKNLFYRHSFIYR 232

4g1m YMSQTTVDILLSTAMGVKKLPEGN----KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYK 250

4G1ps YMSTTTVDILLSTAMGVKKLPEGN----KSFEYAQAVVDMCDIIHKRQVKLLYRLDSIYK 248

4g15m YMSEATVEILLETAMGVSKKTQDK----SGFEYAMAVMRMCDILHARHRSIFLRNEFVFT 238

4G15ps YMSEATVEILLETAMGVSKKTQDK----SGFEYAMAVMRMCDILHARHRSIFLRNEFVFT 238

4d2m VICLTALDIIAETAMGTKINAQKN----PNLPYVQAVNDVTNILIKRFIHAWQRVDWIFR 226

4D2ps VVCLLALDIIAETAMGTKIQAQMS----PNLPYVQAVTDVTNIMTTRFIHAWQRIDWLFR 227

4d14m VACLCAMDIIAETAMGVKINAQLQ----PQFTYVQSVTTASAMLAERFMNPLQRLDFTMK 228

4d14ps VACLCAMDIIAETAMGVKINAQLQ----PNFPYVQSVKTASGMLAERFVNPAQRLDISMR 228

4d8m SICAAALDIIAETAMGTKIYAQAN----ESTPYAEAVNECTALLSWRFMSVYLQVELLFT 225

4d8ps PVCMAALDIIAETAMGTKIHAQAA----ESTPYAEAVNECTALLSWRFISVYLQVELLFT 225

4ae1m LVGLAALDIITETAMGVNVDAQG-----ADSEVVHAVKDLTNILATRFMRPHLLFPHLFR 228

4AE1ps YVGLAALDIITETAMGVCVNAQLD----ADSAVVQAVKAVTNTLATRFMRPHLLPPLLFR 230

4d20m YVSLAALDVITEAAMGVQVNAQND----PDFPYIKALKSVVYIQPDRMFRFSRRYNWLFP 228

4D20ps YVSLAALDVITEAAMGVQVNAQSD----SEFPYVQALKSVVYIQSDRMFRFLQRYDWLFR 229

4d21m FVSLEALDVTTETAMGVQVNAQNE----PNFPYTKALKSVVYIESKRLASVSMRYNWLFP 228

4e2m QAHYLTLDVICDTAMGVSINAMEN----RSSSIVQAFKDMCYNINMRAFHPLKRNELLYR 228

4e2ps ETHYLTLDVICDTAMGVSVNAMEN----RSSSIVQAFKDMCYCINMRAFHPFKRNDLFFR 228

4e1m EAHYLTLDVICDTAMGVSINAMEN----RSSSVVQAFKDITYTIKMRAFSPWKRNKYLFH 228

4e1ps QAHFLTLDIICETAMGVSINAMEN----QDSELVQAFKDMCYNIKVRTFSSWKRNPTLYQ 228

4e3m HANYLTLDVICDTAMGVPINAMEQ----RDSSIVQAFRDMCYNINMRAFHPFKRSNRVFS 228

4e3ps HAHYLTLDVICDTAMGVPINAMEH----RNSAIVQAFKDMCLSVNMRAFHPFKRSNRIYS 228

4ad1m LVAKCTLDIVCENATGQDSSSLNG----ETSDLHGAIKDLCDVVQERTFSIVKRFDALFR 230

4AD1ps LVAKCTLDIVCENATGLVSNSLND----EPSDLHGAIKDLCDVVQERTFSIVKRFDALFR 230

4p1m VIPRFTLNSICETAMGVKLDEMAE----KGDRYRENFSQIEECFIRRLSNPLLWGDKLFE 239

4p3m VIPRFTLNSICETAMGVKLDEMAE----KGDRYRENFRQIEECFIRRMSNPLLWSDTLFK 239

4p1ps LIPRFTLNSICETAMGVKLDEMAE----KGDRYREGIHMIEMSFIRRLSNPLLWNKTIYN 239

4P2ps LIPRFTLNSICETAMGVKLDEMAE----KGDRYREGIHMIEMSFIRRLSNPLLWNKTIYN 241

4P3ps LIPRFTLNTICETAMGVKLDEMAD----KGDRYRESFHMIEKSFVRRLSNPFLRSTTIYN 240

4p2m RISRFTLNSICETAMGIKLDEMAE----KGDRYRANFHIIDEGLTRRIVNPLYWDDCVYN 241

4ac1m VIPPFTLNNICETALGVKLDDMSE-----GNEYRKAIHAIEEVLIQRVCNPLMYYNWYFF 240

4AC1ps VIPQFTLNNICETALGVKLDDMSE-----GNQYRRAIHAIEEVLIQRVCNPLMFYNWYFF 240

4ac2ps VIPQFTLNNICETALGVKLDDMAE-----GFQYRESIHAIEAVILQRICNPFLYNSLYFY 241

4ac2m VIPQFTLNNVCETALGVKLDDLSE-----GIRYRQSIHAIEEVMQQRLCNPFFYNIVYFF 241

4ac3m IIPQFTLNNICETALGVKLDDMSE-----GNEYRKAIHDFEIVFNQRMCNPLMFFNWYFF 240

311a1m PLFACLLDAIVDTSMGAQLDTQSV----DHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQ 221

311a1ps PLFACLLDAIVDTSMGEQLETQSV----AHSPIIKAFHRSSQLLFKRMINPLLASDWVFK 170

316a1m TVSPIVLDLMVMTTCGAKPSEEYS----------KNLKDLSEIYRKRFLSLQSANRFNYW 217

316A1ps IVAPAVRDLMVLTTCGVRPSEGYS----------EAFTCLTEIYRKRFLSLQSVNRFTFW 218

313a2m DLIRWSFAIATQTTLGTDVTKDDNF---ENDAILKTYQSMLRLTIINIFVPFVQNKIVSK 227

313a3m DIVRWSFRIATQTTVGTDVKKDASF---KNDSVLKSYETFMKIIVMNVLLPFTHNKIFST 227

313a1m EMLRWSFKIAAQTTMGSEVKHDEHF---KNGSLVESFESLISHSTLNILMPLVQNRMISK 227

313C1ps EFINWSFRTSIQSTMGSDLKDNPSI---MNGAIQKKISNLIEVTYYLITFPWLQNRAIST 226

313C2ps NVLNWSFRTAYQTTLGSDVKANTSF---KNGTLLKNFKYTMENTTLAILFPLVQNRIIAK 226

313a5m ELNKWSFKIAAQITMGDEVRNQANY---QNGNLLESYKALNNLIPIGVVMPWLRNKYLGK 226

313a4m LLQSFTLGIATQTTMGSDVKDEESF---RSNSLLGRYQCILETMTDMCFSPWLNSRFCRQ 225

313a4ps LLQSLTLGIATQTTMGCDVKSEENF---MSNSLMERYQCCLETMTDMCFSPWLNSRWARQ 225

313A4bps LLQNFTMGITTQTTMGLDVKSEANF---N--SIVESYHCCLETITDMCISPWLHFKWVRQ 223

313b1m ILKKIVLEAACQTTMGKKMNFQHDG---S-LCIFKAYNGLTEVCVKRMLSPWLYPDLIYR 226

313b1ps ILKKIVLEAACQTTMGRKMNFQQDG---S-AAIFEAYNGLTEVCVKRMLSPWLP-ELIYR 227

318a1m LLSRAVLEVSCLTIMGTPTNFTQLD---D-AHIAHSYKRLLEISAVRVVKPWLQIRLLHR 231

318A1ps MLSRAVLEVSCLTVMGTPTNFTQTD---D-AHIASSYKRLLEISAIRVVKPWLQIDLLHR 231

18a1m VISVAVSNVICSLMMSTRFS--IDD-----PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ 246

18a1ps VISVAVSNVICSLMMSTRFS--IDD-----PKFRRFNFLIEEGMRLFGEIHTVDYIPTMQ 247

306A1m ALHHSLGNIINDLVFGITYK--RDD-----PDWLYLQRLQEEGVKLIGVSGVVNFLPWLR 248

306A1ps ALQHTLGNIINDLVFGVTYE--RQD-----PDWLYLQRLQEEGVKLIGVSGVVNFLPWLR 253

303a1m LTSVYVLNTLWCMLSGRRYE-PGSP-----EITQLLETFFELFKNIDMVGALFSHFPLLR 234

303A1ps LTSVYVLNTLWCMLSGQRYD-PGSV-----EITELLETFFELFKNIDMVGALFSHFPLLR 234

305a1m WLAQSVLNVLWCLIAGKRIARQEDG-----TLRRLLDLMNRRSKLFDICGGLLAQFPWLR 229

305A1ps WLAHGVLNVLWCLIAGKRIASEGNS-----MLQRLLDLMNRRSKLFDVCGGLLAQFPWLR 229

304a1m LFNPFSANAHFYIVYNECLSREEMG-----KLVKLCQMGIQFQRNADDYGKMLSIIPWIR 242

304a1ps LFNPFSVNSHFHVVYNERQSREDMA-----GLVRLVQMGMQFQRHADDYGRLLSIMPWIR 242

307a1m LILKACANMFSQYMCSLRFD--YDD-----VDFQQIVQYFDEIFWEINQGHPLDFLPWLY 256

307a1ps FLLRACANMFSQYMCSQRFD--YDD-----EEFHKIVQYFDEIFWEINQGHPLDFLPWLY 251

307a2pm ------------------------------------------------------------ 145

307a2pps LILGASANMFCQYMCSIRFD--YND-----KEFRRIVRYFDEIFWEINQGYSLDFLPWML 251

7A 7B 7C 7D 7E

12a4m KTPKLKRLMRAL---DGIQEVTLAYVDEAIERLDKEAK------------------------- 299

12a5m KTPLLKKMLRTM---DSVQEVTLKYVDEAIERLEKEAK------------------------- 299

12A4ps KTPKLMKLMKAL---DGVQEVTLAYVDEAIERLEKEAK------------------------- 298

12A5ps KTPKLMKLMKAL---DGVQEVTLAYVDEAIERLEKEAK------------------------- 298

12c1m PTPTYKKFSRAM---DEIFDTCSMYVNQAIERIDRKSS------------------------- 291

12c1ps STPTYRKFSQAS---DAIFDTCSMYVNEAVARIDGQS-------------------------- 300

12e1m PMPNFKKLMRSL---DTITDFCYFHIGNALKRIEEDAK------------------------- 281

12e1ps PVPKFNQLMRSL---DTMTDFCVTHIEQALQRIEEDVK------------------------- 283

12d1m STPTYRKMKRTL---NDSLNVAQKMLKENQDALEKRRQ------------------------- 293

12d1ps STPTYRKMMRTL---NESLDVAQRVLAESQQLLEHRRR------------------------- 293

12b2m KTAGFKKFLKTY---DNITDITSNYIETAMRGFGKND-------------------------- 302

12B2ps KTRGFNRFLKTY---DDITEITTNYIEEAIQRFKIDD-------------------------- 305

49A1m PTKAYRSFVKAL---DQFTAICMKNIGKTMDKADADEA------------------------- 353

49A1ps PTKAYRSFVRAL---DQFTAICMKNIGQTMDKAEADEA------------------------- 358

301a1m PTPLWTRYVKNM---NFFVGVCMKYIQSATERLKTQDP------------------------- 327

301A1ps PTPLWTQYVKNM---NFFVGVCMKYIQSATERLKTQDP------------------------- 332

302a1m ETPSFRKLSQAQ---SYMESVALELVEEN---------------------------------- 261

302A1ps ETPSYRKLRQAQ---SYMESVALKLMES----------------------------------- 261

314a1m PTKTYRDFARAE---DLIYDVISEIIDHELEELKKSAAC------------------------ 312

314a1ps PTKTYRDFARAE---DLIYDVISEIIDNELEEHKKSAEC------------------------ 313

315a1m RLPIWRDFEANV---DEVLREGAAIIDHCIR---------V---------------------- 305

315a1ps RLRIWRDFESNV---NEVLREGAAIIDHCIGGEITEDGQLE---------------------- 307

6a2m FPKLASRLRM-----RMMPEDVHQFFMRLVNDTIALRE------------------------- 262

6a2ps FPKLARRLRM-----RIMPEDVHQFFMRLVNDTVAVRE------------------------- 262

6a8m YPKLARKLGM-----VRTAPHIQEFYSRIVTETVAVRE------------------------- 262

6a18m YPNLARRLGL-----CRNTAQIQEFYQRIVKETVTLRE------------------------- 262

6a8ps YPKLARRLRL-----VRTPTHIRNFYERIVHETVAMRE------------------------- 262

6a9m FQNLARRLHM-----KITLEEAEHFFLRIVRETVAFRE------------------------- 261

6a21m FPNLARRLHM-----KMTAEPIERFFMRIVRETVAFRE------------------------- 261

6a21ps FPKLSRKLHL-----KMTAEPIEQFFMRIVKETVKFRE------------------------- 263

6a17m FPKLSRRLRL-----KLNIQEAEDFYTKIVRETIDYRL------------------------- 260

6a23m FPKLSRRLRL-----KLNVQDVEDFYTSIVRNTIDYRL------------------------- 261

6A17ps FPKLSRSLRL-----KLNVQEVEDFYTKIVRDTIDYRL------------------------- 259

6A23ps FPKLSRSLRL-----KLNVQEVEDFYTKIVRDTIDYRL------------------------- 258

6a20ps APKLAAKLRM-----KETVQKVEDFYMKIVRETVDYRL------------------------- 259

6a20m APELAAKLRM-----KATVQEVEDFYMNIIRDTVDYRV------------------------- 271

6a19m MPKLAVKLGF-----QFLLPSVQKFYMKIVQDTIDYRM------------------------- 261

6a22m FPEVARFLRM-----RQIHQDITDFYVGIVRETVKQRE------------------------- 261

6A22ps FPDLARRLRM-----CQIHQDITDFYLGIVKETVKLRE------------------------- 261

6a13m QPELARKLRF-----RLFRPEVSEFFLDTVRQTLDYRR------------------------- 255

6A13ps QPKLARMLHM-----RLFRPEVSEFFLETVRQTLAYRK------------------------- 255

6a14m NARLARKLRI-----KVLPDDLTQFFMSTVKNTVDYRL------------------------- 272

6A14ps NAKLAKKLRM-----KLLPDDVSEFFMNAVKNTVDYRM------------------------- 253

6a15pm NSKLAKKLKM-----KILRDDLTDFFLSVVKPALSG--------------------------- 36

6a16m YLSSLAKLGLPV---RILHPDITKFFNRIVRETVELRE------------------------- 257

6A16ps YWSVLAKLKLSV---RFYDKIIADFFTRIVREKLELRQDL----------------------- 259

6u1m FPLIARLLQY-----KSYAEPATAYFQKVALSQLQL-HRR----------------------- 252

6u1ps FPLLAQLLNH-----KSYAVSAMTYFQKVVLGQLQE-QRR----------------------- 254

317a1m FPNFCRMLRM-----RRTPKQAEEYFIKLLTSIVE--QRE----------------------- 270

317a1ps FPNFCRVLRM-----RRTPKQAETYFLTLLSDIVG--QRE----------------------- 270

6g1m LPKLVSLMRI-----QFFTADFSHFMRSTIGHVMEERE------------------------- 266

6G1ps LPKLVSLLRI-----QFFTQEFAHFLRSTISHVMEERE------------------------- 268

6w1m IPALASLARV-----KLFSRETTKFIRSSVNYVLKERE------------------------- 259

6w1ps LPALTTLAKV-----KVFSKSTSQFIRSSINYVMAERE------------------------- 261

6v1m LPKLVPLLRP-----KLFTEPHAEFLRRVIQLVIEERE------------------------- 272

6v1ps LPKLVPLLRP-----RLFTEPHAEFLRRVIQLVIEERE------------------------- 273

6g2m LPHLVPFVRF-----KVVPAEATRFLRKTINYVMSERE------------------------- 267

6g2ps LPHLVPLFGF-----KVVPSEATRFLRNTINYVMAERE------------------------- 267

6t1m FPRLSHRVGT-----HLYSEEYERFMRKSMDYVLSQRA------------------------- 283

6t2pm -HHLFTRVRT-----HLYSEEYERFMRKSMNYVLAQRA------------------------- 247

6t1ps FPRLSRMVRT-----HLYSDEYERFMRQSMDFVLAQRE------------------------- 287

6t3m LPKWTGVLKP-----KVFTEDYARYMRH---LVDDHHE------------------------- 261

6t3ps LPQWTNLLRA-----KVFSEEYAQFMRG---LVGHPRE------------------------- 262

9b1m APKVFNFFKL-----TIFDSTNVEYFVRLVVDAMQYRE------------------------- 265

9b2m VPKLFSLLKL-----TIFDSAKVDYFARLVVEAMQYRE------------------------- 265

9B2ps IPKVFLFFNM-----KIFNGQKVEYFVRLVVDAMKYRE------------------------- 265

9f2m LKGLNKILKV-----ELFDRKSTQYFVRLVLDAMKYRQ------------------------- 269

9f3pm LKSLNKILKV-----EIFDRKSTQYFVRLVLDAMKYRQ------------------------- 269

9F2ps LKSLNKYIKV-----DLFDKKSTEYFVRLVLDAMKYRQ------------------------- 270

9c1m MPKLMKALRV-----PVMDMNNVDYFKKLVFGAMKYRK------------------------- 265

9c1ps LPKLMKALRV-----SVMDMNNVDYFKKLVFGAIQHRK------------------------- 268

9h1m FPRLMKVLRI-----QVLDTKNIDYFSSLVTAAMRYRQ------------------------- 267

9h1ps VPRLMKLLRI-----QVLDFEKIDYFTSLVKVAMRYRK------------------------- 267

6d2m CPPIAKLMNR-----LGYESRILTSLRDMMKRTIEFRE------------------------- 257

6d2ps CPPIAKLMNR-----LGFESAILTALRDMMKRTIEFRE------------------------- 261

6d4m VPSIAQFLFR-----IGFKNPVGLAMLQIVKETVEYRE------------------------- 260

6d4ps VPSVAKFLFS-----LGFKNQVALAMLEIVKETIEYRE------------------------- 260

6d5m YPGLEKFFVK-----IGWKQEATERMRELSNRTVDLRE------------------------- 258

6D5ps FPGLEKIFVR-----LGWSQEGPERIRELSNRTVDLRE------------------------- 258

310a1m QSFT---LGR-----LPQKSSYTYRLRDLIKQSVELRE------------------------- 229

310a1ps QSFT---LSR-----LPQKSSFTYRLRDLIKQGVEHRE------------------------- 230

28a5m FPSLSHLIKL-----RFVPVDVERFFVDLMGSAVETRRAQLAA-------------------- 270

28A5ps FPSLSHLIKL-----RFVPPKVERFFIELMENAVKARRAQLVA-------------------- 270

28d1m WPPITKFYSV-----SLFAKDVAAFFYDLMQKCIQVRRESPAA-------------------- 272

28d1ps WPPIRKIYSV-----PLFAKEVEQFFFDIMEKCIILRRENPKQ-------------------- 272

28d2m WQKVRKFYSV-----PFFNKETEVFFLDIIRRCITLRLEKPEQ-------------------- 272

28c1m FPNLPRWLRP-----KVFPRSHDRFYGQMISEALRLRRSKHQ--------------------- 267

28c1ps FPRLPRWLRP-----KIFPRSYDRFFGDLIRQAFSLRRGQHQ--------------------- 267

309a1m AIFVRKLFSM-----RFFTKATDEFFLRLTQDAVNLRQGGS---------------------- 275

309a1ps APFLRKVLQM-----RFFTKTAEQFYLQLTRDALRLRHSGS---------------------- 275

309a2m APCSRLLLRF-----RFYPKETDEFFSNLTKESIELRLKAG---------------------- 274

309a2ps APFSRLLLRL-----RFYPKETDEFFSRLTKESIDMRLSAGN--------------------- 277

308a1m TPRLGRLIGH-----RYVPLPLQHWFRELVEARSGG--------------------------- 258

308a1ps SSRLANILQH-----RYVPLSLQDWLCALVRARSGA--------------------------- 267

4aa1m WTKMAN--DE-----LNQKKRLNDFTRKMIQRRRQIQNNN----------------------- 278

4aa1ps WTKLAN--DE-----LNQKKRLHDFTRQMIKIRREILANTG---------------------- 290

4C3m LTAEYKLHQ-------SYINTLHGFSNMVIRERKAELAILQENNNNNNNN------------- 297

4C3ps LTADYKLHQ-------SYINTLHGFSNMVIRERKSELALLQDNNNNNNN-------------- 296

4d1m LTPLARAEK-------KALNVLHQFTEKIIVQRREELIREGS---SQES-------------- 272

4D1ps LTPLARAEK-------RALHVLHEFTEKIIVQRREELIRGGSKDAAAAS-------------- 275

4d1malt LTPLARAEK-------KALNVLHQFTEKIIVQRREELIREGS---SQES-------------- 263

4D1psalt LTPLARAEK-------RALHVLHEFTEKIIVQRREELIRGGSKDAAAAS-------------- 276

4s3m HTKPGKERE-------AALKVLHDETNRVIRLRREQLIQER-----NEWK------------- 261

4s3ps YTQAGQERD-------GALRVLHDETNRVIRLRREQLVKERQ----LQQR------------- 262

312a1m RTSHYKREQ-------ELIKTLHGFTEGIIQKRIDEINQDAE----NRNY------------- 270

312a1ps RTALFRREQ-------ELLKTLHGFTEGIVQERQHQFNLDEV----NRNT------------- 271

4g1m FTKLREKGD-------RMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGL 306

4G1ps FTKLREKGD-------RMMNIILGMTSKVVKDRKQNFQEESRAIVDEVQA--VSTPATKKEGL 302

4g15m LTRYYKEQG-------RLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNG 294

4G15ps LTRYYKEQG-------RLLSIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALERERGQEQ 294

4d2m LTQPTEAKRQ-----DKAIKVMHDFTENIIRERRETLVNNSKETT-PEEE------------- 270

4D2ps LVHPGMAKRQ-----DSAIKVMHDFTENIIKQRRQALVSAGKQEK-EKEE------------- 271

4d14m LFYPKLLDKL-----NDAVKNMHDFTNSVITERRELLQKAIADG--GDAD------------- 271

4d14ps LFFPSAFAKL-----SANIKAMQDFTNNVISERRDLLQKSISDGTYETTN------------- 273

4d8m LTHPHLKWRQ-----TQLIRTMQEFTIKVIEKRRQALEDQQ-----SKLM------------- 265

4d8ps LTHPYMKWRQ-----TQLIRTMHDFTTKVIEERRRTLEEQQG----SKLS------------- 266

4ae1m LCWPSGFRKQ-----QAGVICLHEFTNGIIEQRRRLLAREA---------------------- 264

4AE1ps LCWPSGFRKQ-----QEGIKCLHLFTNSIIEQRRQLLRREN---------------------- 266

4d20m LAAPLLHRQL-----LSDIRVMHDFTDKVISERRETVRRAKADG-TYRPL------------- 272

4D20ps LTCPVLRSKL-----LKDVRVMHDFTDKVIRERRAAVEQAKADG-SYRPL------------- 273

4d21m LAAPLVYRRL-----QKDIAIMQDFTDKVIRERRAILERARADG-TYKPL------------- 272

4e2m LAPDYPAYS-------RTLKTLQDFTNEIIAKRIEAHKSGA-------VS------------- 264

4e2ps LAPDYPAYC-------KTLKTLQDFTNNIIEKRIKAHKDGT-------VS------------- 264

4e1m FAPEYPEYS-------KTLKTLQDFTNEIIAKRIEVRKSGL-------EV------------- 264

4e1ps FASDYPAYC-------KTLKTLQDFTHDVIEKRLNAHKEGT-------VL------------- 264

4e3m LTPEFSAYQ-------KTLKTLQDFTYDIIEKRVYALQNGG-------SK------------- 264

4e3ps LSPEYAAYQ-------RTLKTLQDFTYDIIEKRVETLQAGQ-------NS------------- 264

4ad1m LTSYYMKQR-------RALSLLRSELNRIISQRRHQLAAEN-------TC------------- 266

4AD1ps LTSYYMKQR-------RALSLLRREIYRIITQRRQQLADEN-------TC------------- 266

4p1m MFAAK---DF-----ASALDVVHRFSSEIIAKRRDLLKDELDK--SSSTA------------- 279

4p3m MFAEK---DY-----ASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTA------------- 281

4p1ps WFAAK---TY-----DAFLKTVHEFSSEIIAKRRILLEEELEHRRSTQTA------------- 281

4P2ps WFAAK---TY-----DAFLKTVHEFSSEIIAKRRILLEEELEHRRLTQTA------------- 283

4P3ps LFVAK---EY-----APFLKVVHDFSSEIIAKRRILLEEELEHRRSTQTA------------- 282

4p2m MFTGH---KY-----NAALKVVHEFSREIIAKRRVLLEEELENRRATQTA------------- 283

4ac1m VYGDYR--KH-----LQNLRIVHDFSSRIIERKRQQFQQKQLG-------------------- 276

4AC1ps LIGDYR--KQ-----VQNLRIVHDFSSRIIERKRQQFKRKQLG-------------------- 276

4ac2ps LYGDYR--KH-----IDSLKIAHDFSSSIIERRRRDIKRKELG-------------------- 277

4ac2m LFGDYR--KQ-----VNNLKIAHEFSSNIIEKRRSLFKSNQLG-------------------- 277

4ac3m LFGDYK--KY-----SRILRTIHGFSSGIIQRKRQQFKQKQLG-------------------- 276

311a1m RTQLWR--DL-----DEQLQVIHSQMESVIEKRAKELLDMGE--------------------- 256

311a1ps QTRLWR--EL-----SEQLQVIHTLMDSLIDRRSAQLQQQGN--------------------- 205

316a1m LSSPFMRKRQ-----NRLIKRLNDEHNNLMAMHQ---SQNQLKIEN--G-------------- 256

316A1ps VSSPLLRRRQ-----AQLIKQLNDEHKEHIDRFRRLQKQEEQLKAG--N-------------- 260

313a2m LFGLEWLR-------RRDASAINKMINNILDKKLNSNPENYCE-------------------- 263

313a3m LGGFETQK-------ALAKSNVNKMIGTIVDKKLMTKPESGSQ-------------------- 263

313a1m ICGYDKLR-------ADNFSRIQKMLDNVVNKKVNPLPKTDSD-------------------- 263

313C1ps LFGFEKRK-------SEAMIHLNASLQSILQEKLKTQGDESKE-------------------- 262

313C2ps LLGIEKRR-------TEATFIVNELTKSLIEEKMTNKPDENQE-------------------- 262

313a5m LFSYEKRR-------LEAATQSNAFIKDIIDKKLSSTDNSSEP-------------------- 262

313a4m LAGKESHY-------YQAKTEIRQFIRKIIERKLAEDEMGALP-------------------- 261

313a4ps LSGKEANY-------YRAKTEIRAFIRKLIQKRLSEDTEDSIK-------------------- 261

313A4bps LTGREKNY-------HRSKTEIRAFLNKLIQKRLAEDTEDSIK-------------------- 259

313b1m RSGLFRLQ-------QKVVGILFGFIEQLLEPIVSVVAANSNPDQQRSEM------------- 269

313b1ps RSRLFVQQ-------TKVVGVLRGFIEQLLSPIVSVVDLDTS--KEPLQQ------------- 268

318a1m LLAPELYEES-----KKCAKLLEDFVGGIVRTKHRNWRLRDAVGGEKS-G------------- 275

318A1ps LLAPELYAEA-----EKCNQLLVEFVAGIVQSKHRNWQLRAALCEG---A------------- 273

18a1m CFPSISTAKNK---IAQNRAEMQRFYQDVIDDHKRSFDP------------------------ 282

18a1ps CFPSISTAKNK---IAQNRAEMQRFYQDVIDDHKRSFDP------------------------ 283

306A1m HLPANVRNIRF---LLEGKAKTHAIYDRIVEACGQRLKEKQKVF------------------- 289

306A1ps RLPWNRRNICF---LMEGKSRTHAIYDRIVESCENRLKELQEQY------------------- 294

303a1m FIAPNFSGYNG---FVESHRSLYTFMSKEIELHRLTYKNYDE--------------------- 273

303A1ps FIAPDYSGYNG---FVESHRALYSFMSKEIELHRRTYRSFDE--------------------- 273

305a1m HVAPDRTGYNL---IQQLNTELYGFFMDTIEEHRRQLAKDPS--------------------- 268

305A1ps HVAPDRTGYNL---IRQLNTELYGFFMDTIADHRRQLEKASDN-------------------- 269

304a1m HIWPEWSGYNK---LNESNLFVRQFFADFVDKYLDSYEEGVE--------------------- 281

304a1ps HVWPEWSGYKK---LNESNQFMRQYFAEIVDRHIETYEEGSE--------------------- 281

307a1m PFYQR--HLNK---IINWSSTIRGFIMERIIRHRELSVDLDE--------------------- 293

307a1ps PFYRR--HLNK---IVHWSSTIRSFIMDRIISHRELDIDVDE--------------------- 288

307a2pm ---------------------------------------------------------------

307a2pps PFYKN--HTQK---IVQWSTTIRKFILDRVIHQREEMLDLDE--------------------- 288

8A 8B

12a4m -------------------------------------------------EGVVR--PENE 308

12a5m -------------------------------------------------EGVVR--PEHE 308

12A4ps -------------------------------------------------EGVVR--PESE 307

12A5ps -------------------------------------------------EGVVR--PENE 307

12c1m -------------------------------------------------Q--GD--SNDH 298

12c1ps -------------------------------------------------A--AE--REGR 307

12e1m -------------------------------------------------AGTLN-EIGLE 291

12e1ps -------------------------------------------------AGKMSPEMGME 294

12d1m -------------------------------------------------AG--EK--INS 300

12d1ps -------------------------------------------------AG--EQ--VNS 300

12b2m -------------------------------------------------DG--K-----T 306

12B2ps -------------------------------------------------GR--K-----N 309

49A1m -------------------------------------------------RGLSKSEADIS 364

49A1ps -------------------------------------------------RALPKSEADIS 369

301a1m ----------------------------------------------------SLRAGEPS 335

301A1ps ----------------------------------------------------SQRAGEPS 340

302a1m --------------------------------------------------VRNGSVGSSL 271

302A1ps ----------------------------------------------------SSSEQSSL 269

314a1m -------------------------------------------------EDDEAAGLRSI 323

314a1ps -------------------------------------------------DDEGASGLRSV 324

315a1m -------------------------------------------------QEDQRRPHDEA 316

315a1ps -------------------------------------------------HLEQLEQREET 318

6a2m -----------------------------------------------RENFKRNDFMNLL 275

6a2ps -----------------------------------------------KENFKRHDFMDML 275

6a8m -----------------------------------------------KEHIKRNDFMDML 275

6a18m -----------------------------------------------KENIKRNDFMDML 275

6a8ps -----------------------------------------------KENIKRNDFMDLL 275

6a9m -----------------------------------------------KNNIRRNDFMDQL 274

6a21m -----------------------------------------------QNNIRRNDFMDQL 274

6a21ps -----------------------------------------------QNQIRRNDFMDQL 276

6a17m -----------------------------------------------RTKEKRNDFMDSL 273

6a23m -----------------------------------------------RTNEKRHDFMDSL 274

6A17ps -----------------------------------------------KTKEKRNDFMDSL 272

6A23ps -----------------------------------------------KTKEKRNDFMDSL 271

6a20ps -----------------------------------------------KNNVKRNDFMDML 272

6a20m -----------------------------------------------KNNVKRHDFVDML 284

6a19m -----------------------------------------------KRKVTRNDFMDTL 274

6a22m -----------------------------------------------EQGIVRSDFMNLL 274

6A22ps -----------------------------------------------EQGIVRNDFMNLL 274

6a13m -----------------------------------------------RENIHRN---DLI 265

6A13ps -----------------------------------------------RENVQRS---DLI 265

6a14m -----------------------------------------------KNGIKRNDFIEQM 285

6A14ps -----------------------------------------------KNGIKRNDFLDEL 266

6a15pm --------------------------------------------------------MTLW 40

6a16m -----------------------------------------------RENIRRNDFMDLL 270

6A16ps -----------------------------------------------RHNIKRNDFLELL 272

6u1m -----------------------------------------------RDRQPLQTFLQLY 265

6u1ps -----------------------------------------------RDRQPLQTFLQLY 267

317a1m -----------------------------------------------TSGKPQKDYLQLL 283

317a1ps -----------------------------------------------ASGVRHQDYLQLL 283

6g1m -----------------------------------------------RSGLLRNDLIDVL 279

6G1ps -----------------------------------------------RTGFVRNDLIDVL 281

6w1m -----------------------------------------------RTGEKRNDLIDIL 272

6w1ps -----------------------------------------------RSGLRRNDLVDVL 274

6v1m -----------------------------------------------RGGDLRNDLIEML 285

6v1ps -----------------------------------------------RGGDLRNDLIEML 286

6g2m -----------------------------------------------KSGQKRNDLIDIL 280

6g2ps -----------------------------------------------RSQQTRNDLIDIL 280

6t1m -----------------------------------------------ESGENRHDLIDIF 296

6t2pm -----------------------------------------------EN-EKRYDLIDMF 259

6t1ps -----------------------------------------------KSGEKRHDLIDIF 300

6t3m -----------------------------------------------PT--K-GDLINQL 271

6t3ps -----------------------------------------------RS--K-GDLIDQL 272

9b1m -----------------------------------------------KHNITRPDMIQLL 278

9b2m -----------------------------------------------KHNITRPDMIQLL 278

9B2ps -----------------------------------------------EHNINRPDMIQLL 278

9f2m -----------------------------------------------EHNIVRPDMINML 282

9f3pm -----------------------------------------------EHNIVRPDMINML 282

9F2ps -----------------------------------------------EHNIIRPDMINML 283

9c1m -----------------------------------------------EQSIVRPDMIHLL 278

9c1ps -----------------------------------------------EHNIIRPDMIQQL 281

9h1m -----------------------------------------------EHKVVRPDMIHLL 280

9h1ps -----------------------------------------------EHNVLRPDMIHLL 280

6d2m -----------------------------------------------EHNVVRKDMLQLL 270

6d2ps -----------------------------------------------SNNVVRKDLLQLL 274

6d4m -----------------------------------------------KHGIVRKDLLQLL 273

6d4ps -----------------------------------------------KHGIVRKDLLQLL 273

6d5m -----------------------------------------------QNNIVRKDLLQLL 271

6D5ps -----------------------------------------------EKNIERRDLLQLL 271

310a1m -----------------------------------------------DHGLIRKDILQLL 242

310a1ps -----------------------------------------------EHGLIRKDILQLL 243

28a5m -----------------------------------------------GKQFERSDFLDYI 283

28A5ps -----------------------------------------------GKQFERTDFLDYI 283

28d1m -----------------------------------------------QQ---RDDFLNYM 282

28d1ps -----------------------------------------------Q----REDFLNYM 281

28d2m -----------------------------------------------Q----RDDFLNYM 281

28c1m -----------------------------------------------E----RNDFINHL 276

28c1ps -----------------------------------------------E----RNDFINHL 276

309a1m -------------------------------------------------GEGRTDYLSHL 286

309a1ps -------------------------------------------------GSDRTDYLSHL 286

309a2m -------------------------------------------------DSTRTDYLSHL 285

309a2ps -------------------------------------------------DITRTDYLSHL 288

308a1m -----------------------------------------------------DNLLQWL 265

308a1ps -----------------------------------------------------NNFLHWL 274

4aa1m -----------------------------------------------NGNSERKCLLDHM 291

4aa1ps -----------------------------------------------NNNAERKCLLDYM 303

4C3m ----------------------------------------APDAYDDVGKKKRLAFLDLL 317

4C3ps ----------------------------------------TPDAYDDVGKKKRLAFLDLL 316

4d1m -----------------------------------------SNDDADVGAKRKMAFLDIL 291

4D1ps -----------------------------------------DDADADVGAKRKMAFLDIL 294

4d1malt -----------------------------------------SNDDADVGAKRKMAFLDIL 282

4D1psalt -----------------------------------------DDADADVGAKRKMAFLDIL 295

4s3m ----------------------------------------PEAEQDDVGAKRRLAFLDML 281

4s3ps ----------------------------------------TEAAQDDVGSKRRLAFLDML 282

312a1m ----------------------------------------QSSDAELDGVKRTLCFLDTL 290

312a1ps ----------------------------------------MSTKDAEMDKRPALSFLDTL 291

4g1m R------------------------------------DDLDDIDENDVGAKRRLALLDAM 330

4G1ps R------------------------------------DDLDDIDENDVGAKRRLALLDAM 326

4g15m GVDQTPSTAGSDEKDREKDKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLM 354

4G15ps KQEQKQEQAEMGSAGGGKAAGEGTPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLM 354

4d2m -----------------------------------------VN---FLGQKRRMALLDVL 286

4D2ps -----------------------------------------IKEDDDLGQKRRMALLDVL 290

4d14m -----------------------------------------AALLNDVGQKRRMALLDVL 290

4d14ps -----------------------------------------ASPLDDVGQKRRMALLDVL 292

4d8m -----------------------------------------DTADEDVGSKRRMALLDVL 284

4d8ps -----------------------------------------PSPDDDVGRKRRMALLDVL 285

4ae1m ------------------------------------------NQDKPTKP---HALLDTL 279

4AE1ps ------------------------------------------APGEPVARDRRNALLDTL 284

4d20m -----------------------------------------SLGDAEIGSKSQMALLDIL 291

4D20ps -----------------------------------------SLGDPEVGRKSQMALLDIL 292

4d21m -----------------------------------------IMGDDDIGGKAKMTLLDIL 291

4e2m -----------------------------------------TNAGDEFTRKK-MAFLDTL 282

4e2ps -----------------------------------------ASQGDEFSRKK-MAFLDTL 282

4e1m -----------------------------------------GIKADEFSRKK-MAFLDTL 282

4e1ps -----------------------------------------ASHGDEFSRKK-MVFLDTL 282

4e3m -----------------------------------------EDHDPSLPRKK-MAFLDTL 282

4e3ps -----------------------------------------SSADSSSPRKK-MAFLDTL 282

4ad1m -----------------------------------------QQ-GQPINKP----FLDVL 280

4AD1ps -----------------------------------------GERTKKINKP----FLDVL 281

4p1m ------------------------------------------DDDGFVS-KKRFAMLDTL 296

4p3m ------------------------------------------EDELFTS-KKRFAMLDTL 298

4p1ps ------------------------------------------DDDIFGSRKKRFAMLDTL 299

4P2ps ------------------------------------------DDDIFVSRKKRFAMLDTL 301

4P3ps ------------------------------------------DDDIFVSRHKRFAMLDTL 300

4p2m ------------------------------------------DDDICVIRKKRFAMLDTL 301

4ac1m -------------------------------------------EVDEFGRKQRYAMLDTL 293

4AC1ps -------------------------------------------VVDDFGKKQRYAMLDTL 293

4ac2ps -------------------------------------------VVDDFGKKQRYAMLDTL 294

4ac2m -------------------------------------------QEDEFGKKQRYAMLDTL 294

4ac3m -------------------------------------------QVDEFGKKQRYAMLDTL 293

311a1m ------------------------------------------------PAGRAHNLLDTL 268

311a1ps ------------------------------------------------EPRKALNLLDTL 217

316a1m ---------------------------------------LDIYQLRPIPLKDHKSLLEIL 277

316A1ps ---------------------------------------VVVDRIDPLPAQWHQSLLEIL 281

313a2m ----------------------------------------------S--EL--KTVIHRA 273

313a3m ----------------------------------------------P--EI--TSVINKA 273

313a1m ----------------------------------------------P--ES--NIVINRA 273

313C1ps ----------------------------------------------S--LASRNIVINRA 274

313C2ps ----------------------------------------------S--FAIRNTVISRV 274

313a5m ------------------------------------------------------ALIDRI 268

313a4m ----------------------------------------------SIQSNDKNLFLNLV 275

313a4ps -------------------------------------------------SKDKNIFLNLA 272

313A4bps -------------------------------------------------SKDKNIFLHVT 270

313b1m --------------------------------------------EM--RGKSKAIFIEQV 283

313b1ps --------------------------------------------ES--KSKSKSIFIEQV 282

318a1m --------------------------------------------EDASNGWQRRIFIEQI 291

318A1ps --------------------------------------------GEDSTAWQRRIFIEQI 289

18a1m --------------------------------------------------NNIRDLVDFY 292

18a1ps --------------------------------------------------HNVRDLVDYY 293

306A1m ----------K---------------------------------ELQEQKRLQRQLEKEQ 306

306A1ps ----------Q---------------------------------EKQRQRQQQQDLQQYQ 311

303a1m ----------------------------------------------------PRDLMDSY 281

303A1ps ----------------------------------------------------PRDLMDSY 281

305a1m --------------------------------------------------PAESDLIYAY 278

305A1ps -------------------------------------------------EPVESDLIYAY 280

304a1m -----------------------------------------------------RNFMDVY 288

304a1ps -----------------------------------------------------RNFIDLY 288

307a1m ---------------------------------------------------PDRDFTDAL 302

307a1ps ---------------------------------------------------PDSDFTDAL 297

307a2pm ------------------------------------------------------------

307a2pps ---------------------------------------------------PENDFTDAL 297

9A 9B 9C

12a4m QSVLEKL---------------------------LKVDR--------------------- 320

12a5m QSVLEKL---------------------------LKVDK--------------------- 320

12A4ps QSVLEKL---------------------------LKVDK--------------------- 319

12A5ps QSVLEKL---------------------------LKIDK--------------------- 319

12c1m KSVLEQL---------------------------LQIDR--------------------- 310

12c1ps RSILEQL---------------------------LQINR--------------------- 319

12e1m TSLLEKL---------------------------ARFDR--------------------- 303

12e1ps ASLLEKL---------------------------ARFDR--------------------- 306

12d1m NSMLERL---------------------------MEIDP--------------------- 312

12d1ps HSMLQRL---------------------------MDIDP--------------------- 312

12b2m KCVLEQL---------------------------LEHNK--------------------- 318

12B2ps KCVLEQL---------------------------LGLNK--------------------- 321

49A1m IVERIVR---------------------------KTGNR--------------------- 376

49A1ps IVERIVR---------------------------KTGNR--------------------- 381

301a1m LVEKVIL---------------------------SQKDE--------------------- 347

301A1ps LVEKVIM---------------------------SEKDE--------------------- 352

302a1m ISAYVKN---------------------------PELDR--------------------- 283

302A1ps ISTYLQN---------------------------PELDH--------------------- 281

314a1m FLNILEL---------------------------KDLDI--------------------- 335

314a1ps FLNILDL---------------------------KDLDI--------------------- 336

315a1m LYHRLQA---------------------------ADVPG--------------------- 328

315a1ps LFNRLQA---------------------------AEVPG--------------------- 330

6a2m IELKQKGRV--------------TLDNG---EVIEGMDI--------------------- 297

6a2ps IEIKQKGSV--------------TLENG---EVMKAMDI--------------------- 297

6a8m IELKNQKEM--------------TLENG---DVVRGLTM--------------------- 297

6a18m IGLKNQKNM--------------TLENG---EVVKGLTM--------------------- 297

6a8ps IDMKNQK-V--------------KLENG---DLVDGLTI--------------------- 296

6a9m IDLKNSPLT--------------KSESG---ESVN-LTI--------------------- 295

6a21m IDLKNKPLM--------------VSQSG---ESVN-LTI--------------------- 295

6a21ps IDLKNNQII--------------KTESG---DNIN-LTI--------------------- 297

6a17m IEMYKNE----------------QS--G---NSEDGLTF--------------------- 291

6a23m IEMYEKE----------------QA--G---NTEDGLSF--------------------- 292

6A17ps IEMYQKE----------------QE--G---NSDEGLTF--------------------- 290

6A23ps IEMYQKE----------------QE--G---NSDEGLTF--------------------- 289

6a20ps IDMKINY----------------DK--G---NKQDGISF--------------------- 290

6a20m IEMKLKF----------------DN--G---DKENGLTF--------------------- 302

6a19m IDMKQQY----------------DK--G---DKENGLAF--------------------- 292

6a22m IEMKQRG----------------E------------LTI--------------------- 285

6A22ps IEMKHRG----------------E------------LTL--------------------- 285

6a13m QLLMELGEE--------------G--------VKDALSF--------------------- 282

6A13ps QLLMDLGEE--------------G--------TKDGLSF--------------------- 282

6a14m IELRAEDQE--------------AAKKGQGIDLSHGLTL--------------------- 310

6A14ps IELRAENQE--------------AAKHGKVIDLSHGLTI--------------------- 291

6a15pm TSPPSGGRS--------------SRQGGSKFDLSHNWTL--------------------- 65

6a16m LDLRR-----------------------------KGLTM--------------------- 307

6A16ps MAS--------------------K--------DDNELTL--------------------- 283

6u1m SNAEKP------------------------------LTD--------------------- 274

6u1ps SNMDQP------------------------------LDD--------------------- 276

317a1m IDVKALEFIT------------HQYEAD---KELGAHLQ--------------------- 307

317a1ps VEIKALELIT------------HQYQAD---KELNTHLQ--------------------- 307

6g1m VSLRKEAAAEPSK-------------------PHYAKNQ--------------------- 299

6G1ps VGLRKEAAEEPSK-------------------PHYARNF--------------------- 301

6w1m LALKREAAANPGK-------------------MSKEVDL--------------------- 292

6w1ps LALKREAAASPDK-------------------NNKAKNM--------------------- 294

6v1m LTLKKEADLQQDK-------------------SHFTHHR--------------------- 305

6v1ps LTLKKEADLQKDK-------------------SHFTHHR--------------------- 306

6g2m IEFRRSTQLAKASG----------------IKDQFVFEG--------------------- 303

6g2ps IEFRRSTQQARAAG----------------DHGQFVFEG--------------------- 303

6t1m LQLKRTEPAE-----------------------SIIHRP--------------------- 312

6t2pm LQMHRTETAE-----------------------GIIHRP--------------------- 275

6t1ps LQLKRTEPPT-----------------------SIIHRP--------------------- 316

6t3m QHFQLSRSSN-----------------------HYSQHP--------------------- 287

6t3ps LHLQSSRPSS-----------------------HYAQHP--------------------- 288

9b1m MEAK--------------------------KESKDNWTD--------------------- 291

9b2m MEAK--------------------------NESEDKWTD--------------------- 291

9B2ps MESK--------------------------TESEDNWTD--------------------- 291

9f2m MEARGIIQTE-----------------KTKASAVREWSD--------------------- 304

9f3pm MEARGIIQTE-----------------KTKASAVREWSD--------------------- 304

9F2ps MEARGLFQTE-----------------KTKTTVIREWSD--------------------- 305

9c1m MEAQRQFKAEQEGSAE-----------SAAQQDKAEFND--------------------- 306

9c1ps MEAQRLFRAEQEASQE-----------TTTQEDRAEFND--------------------- 309

9h1m MEAKQQRLADLSDKSK-----------DELY--YSEFTA--------------------- 306

9h1ps MEAKQLRHAELVNQSK-----------DSSR--YADFTD--------------------- 306

6d2m IRLRNTGKIGEDDDQV-------WDM-ETAQEQLKSMSI--------------------- 301

6d2ps IRLRNTGRIGEDDDEV-------WDM-ETVQEELKAMSI--------------------- 305

6d4m IQLRNTGKIDENDEKS-------FSIQKTPDGHIKTISL--------------------- 305

6d4ps MELRNTGAVDESDENI-------WKIQKSATDQIKCISL--------------------- 305

6d5m LQLRNQGKIN-TDDNI-------WSA-ESTKNGVKSMSK--------------------- 301

6D5ps LQLRNTGKIS-NDDNM-------WSA-QNDNKGLKSVSK--------------------- 301

310a1m VRFRNGN--EVSGDK--------WQL-EPINDADKLLSI--------------------- 270

310a1ps TRFRNGN--DISGDK--------WQI-DIDNEQDKLLSI--------------------- 271

28a5m LQLGE----------------------------KRNLDN--------------------- 294

28A5ps LQMAE----------------------------KRSLDT--------------------- 294

28d1m LQLQE----------------------------KKGLNA--------------------- 293

28d1ps LQLQE----------------------------KKGLDT--------------------- 292

28d2m LQLQE----------------------------KKGLHT--------------------- 292

28c1m LEMQR----------------------------ELDLSE--------------------- 287

28c1ps LALKR----------------------------EHGLTE--------------------- 287

309a1m IQLQ-----------------------------QRGNSI--------------------- 296

309a1ps IQLQ-----------------------------QRGITL--------------------- 296

309a2m LQLRD----------------------------QKQATH--------------------- 296

309a2ps LQLRE----------------------------QKQASH--------------------- 299

308a1m AESK------------------------------RGLGK--------------------- 274

308a1ps GDKQ------------------------------GEQG---------------------- 282

4aa1m IEISES---------------------------NRDFTE--------------------- 303

4aa1ps IEISES---------------------------NPDFTE--------------------- 315

4C3m IDASKEG---------------------------TVLSN--------------------- 329

4C3ps IDASKDG---------------------------TVLTN--------------------- 328

4d1m LQSTVDE---------------------------RPLSN--------------------- 303

4D1ps LQSTIDE---------------------------KPLTN--------------------- 306

4d1malt LQSTVDE---------------------------RPLSN--------------------- 294

4D1psalt LQSTIDE---------------------------KPLTN--------------------- 307

4s3m LLTQMEG--------------------------GAELSD--------------------- 294

4s3ps LLTQLEG--------------------------GDELSD--------------------- 295

312a1m LLSKGPD--------------------------GKPLTV--------------------- 303

312a1ps LQAKTPE--------------------------GASLSV--------------------- 304

4g1m VEMAKNP--------------------------DIEWNE--------------------- 343

4G1ps VEMAKNP--------------------------DIEWNE--------------------- 339

4g15m LESAQN---------------------------GALITD--------------------- 366

4G15ps LESAQN---------------------------GALITD--------------------- 366

4d2m LQSTID---------------------------GAPLSD--------------------- 298

4D2ps LQSTID---------------------------GASLSN--------------------- 302

4d14m LKSTID---------------------------GAPLSN--------------------- 302

4d14ps LQSSID---------------------------GAPLSN--------------------- 304

4d8m LMSTVD---------------------------GRPLTN--------------------- 296

4d8ps LLATVD---------------------------GRPLTN--------------------- 297

4ae1m LRATVD---------------------------GQPLTD--------------------- 291

4AE1ps LRATVD---------------------------GQPLTD--------------------- 296

4d20m LQSSIN---------------------------NQPLSD--------------------- 303

4D20ps LQATIE---------------------------GQPLSD--------------------- 304

4d21m LQATID---------------------------NKPLSD--------------------- 303

4e2m LSSTID---------------------------GRPLNS--------------------- 294

4e2ps LSSTID---------------------------GRPLTT--------------------- 294

4e1m LSSKVD---------------------------GRPLTS--------------------- 294

4e1ps LSATVD---------------------------GRPLTS--------------------- 294

4e3m LSSTID---------------------------GRPLTR--------------------- 294

4e3ps LSSTVD---------------------------GRPLTR--------------------- 294

4ad1m LTAKLD---------------------------GKVLKE--------------------- 292

4AD1ps LAAKLD---------------------------GRALKE--------------------- 293

4p1m IYAEKD----------------------------GLIDH--------------------- 307

4p3m ILAEKD----------------------------GLIDH--------------------- 309

4p1ps ICAEKD----------------------------GLIDH--------------------- 310

4P2ps ICAEKD----------------------------GLIDH--------------------- 312

4P3ps ICAEKD----------------------------GMIDH--------------------- 311

4p2m ICAEKD----------------------------GLIDD--------------------- 312

4ac1m LAAEAD----------------------------GQIDH--------------------- 304

4AC1ps LAAEAE----------------------------GQIDH--------------------- 304

4ac2ps LAAEAD----------------------------GQIDH--------------------- 305

4ac2m LAAEAD----------------------------GQIDH--------------------- 305

4ac3m LAAEAE----------------------------GKIDH--------------------- 304

311a1m LLAKFE---------------------------GQSLSR--------------------- 280

311a1ps LLANID---------------------------GEPLSR--------------------- 229

316a1m LE-SKD----------------------------PQLTG--------------------- 287

316A1ps LAGNHN----------------------------PEISD--------------------- 292

313a2m IELFRN----------------------------DEMSL--------------------- 284

313a3m IELHRN----------------------------GEMSR--------------------- 284

313a1m MELYRK----------------------------GDITY--------------------- 284

313C1ps RDFLRS----------------------------GDFSY--------------------- 285

313C2ps VEFLKS----------------------------GEFSY--------------------- 285

313a5m LNLVRI----------------------------GELSY--------------------- 279

313a4m TDLMRR----------------------------GVFTL--------------------- 286

313a4ps TDLLRR----------------------------GVFDW--------------------- 283

313A4bps TDLLKR----------------------------GVFDL--------------------- 281

313b1m REHVER----------------------------GQLSW--------------------- 294

313b1ps REHVER----------------------------GQLSW--------------------- 293

318a1m FQLAAN----------------------------GEMTL--------------------- 302

318A1ps FQLAAN----------------------------GELTL--------------------- 300

18a1m LC--------------------EIEKAKAEGTDAELFDG--------------------- 311

18a1ps LC--------------------EIEKAKAEGTDAELFDG--------------------- 312

306A1m LR-------------QSKEADPSQEQSEADEDDEESDEEDTYEPECILEHFLAVRDTDSQ 353

306A1ps QQDPQQDPEPESGSEQSLQQSPEQKEEKPKGEEEEDDDDDVYEPTCILEHFLINRVPFSE 371

303a1m LRAQ-----------------------DEGNDEKGMFSD--------------------- 297

303A1ps LRAQ-----------------------EAGNDDKGMFSD--------------------- 297

305a1m LQEMKD---------------------RSAGGESSTFNE--------------------- 296

305A1ps LQEMRD---------------------QSSDSESSSFNE--------------------- 298

304a1m IAEMR-------------------------RGPGYGFNR--------------------- 302

304a1ps ISEMK-------------------------SCPGHGFNR--------------------- 302

307a1m LKS---------------------------LLEDKDVSR--------------------- 314

307a1ps LKS---------------------------LVEDKDVSR--------------------- 309

307a2pm ------------------------------------------------------------

307a2pps LRS---------------------------LKEDQNVSR--------------------- 309

10B

10A 10C 10D 10E 10F 10G

12a4m ----KVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPE-KQARLREEVMKVLPNKNS--- 372

12a5m ----KVATVMAMDMLMAGVDTTSSTFTALLLCLAKNPE-KQARLREEVMKVLPNKDS--- 372

12A4ps ----KVATVMAMDMLMAGVDTTSSTFTAALLCLAKNPE-KQAILREEVMKVLPEKDS--- 371

12A5ps ----KVATVMAMDMLMAGVDTTSSTFTAALLCLAKNPE-KQAILREEVMKVLPEKDS--- 371

12c1m ----KLAVVMAMDMLMGGVDTTSTAISGILLNLAKNPE-KQQRLREEVLSKLTSLHS--- 362

12c1ps ----KFAVVMAMDLLFGAVDTTTSALAGVLLSLAKNPK-QQQMLREEIVSMLPHPDR--- 371

12e1m ----QTAVIIAMDLLFAGADPTLVTLGGILFSLSKSPD-KQARLLEEIRGILPNKDS--- 355

12e1ps ----KTAVIIAMDFLFAGTDPTLVSLVGILLSLAKNPD-KQARLLEEINQILPAKDS--- 358

12d1m ----KVAVIMSLDILFAGVDATATLLSAVLLCLSKHPD-KQAKLREELLSIMPTKDS--- 364

12d1ps ----KLALIMGLEILFAGVDATATLLSAVLLTLAKHPE-KQHKLRAEVRQVMPSKES--- 364

12b2m ----KVAVTMVMDMLMAGIDTTSSACLTILYHLARNPS-KQEKLRRELLRILPTTKD--- 370

12B2ps ----QVAVVMAMDMLMAGIDTTSSAFVTILYHLACNPS-KQSQLRRELLHILPDSKG--- 373

49A1m ----KLAAILALDLFLVGVDTTSVAASSTIYQLAKNPD-KQKKLFDELQKVFPHREA--- 428

49A1ps ----KLAAILALDLFLVGVDTTSVAASSTIYQLAKNPD-KQRRLFEELQRVFPHREA--- 433

301a1m ----KIATIMALDLILVGIDTISMAVCSMLYQLATRPV-DQQKVHEELKRLLPDPNT--- 399

301A1ps ----KIATIMALDLILVGIDTISMAVCSMLYQLATRPE-EQQKVHEELKRLLPDPNT--- 404

302a1m ----SDVVGTAADLLLAGIDTTSYASAFLLYHIARNPE-VQQKLHEEARRVLPSAKD--- 335

302A1ps ----SDVVGTAADLLLAGIDTTSYASAFLLYHVARHPE-VQQRLHAEARRVLPDPDQ--- 333

314a1m ----RDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPG-AMPRILSEFCEYRDTN----- 385

314a1ps ----RDKKSAIIDFIAAGIETLANTLLFVLSSVTEEPS-AMTRILSEFCEYRDTN----- 386

315a1m ----DMIKRIFVDLVIAAGDTTAFSSQWALFALSKEPR-LQQRLAKERATND--S----- 376

315a1ps ----EMIKRIFVDLVIAAGDTTAFSSQWALFVLSREPQ-LQSRLARERVASE--S----- 378

6a2m ----GELAAQVFVFYVAGFETSSSTMSYCLYELAQNQD-IQDRLRNEIQTVLEEQE---- 348

6a2ps ----GELAAQVFVFYLAGFETSSSTMSYCFYELAQHQD-IQDKLRSEVLTVLAEHD---- 348

6a8m ----EEVLAQAFVFFIAGFETSSSTMGFALYELAKNPD-IQDKVRAEVEEVIEQHD---- 348

6a18m ----DEIVAQAFVFFIAGFDTSSSTMGFALYELAKNPS-IQDKVRAELGQVLEQHD---- 348

6a8ps ----DEILAQAFVFLIAGFETSSSTMGYALYELAKQPH-IQDKVRAEVEEVLEQHE---- 347

6a9m ----EEMAAQAFVFFGAGFETSSTTMGFALYELAQHQD-IQDRVRKECQEVIGKYN---- 346

6a21m ----EEIAAQAFVFFAAGFETSSTTMGFALYELAQNQD-IQNRVRKECQEVIEKCN---- 346

6a21ps ----EEIAAQAFVFFAAGFETSSTTMGFALYELAQHPD-IQQRVREECQEVIQKYG---- 348

6a17m ----NELLAQAFIFFVAGFETSSTTMGFALYELARNQD-VQDKLREEIGNVFGKHN---- 342

6a23m ----NEILAQAFIFFVAGFETSSTTMGFALYELALDQD-IQDQLRAEINNVLSKHN---- 343

6A17ps ----NEILAQAFIFFVAGFETSSTTMGFALYELAQNQD-TQDKLRNEINDVLAKHN---- 341

6A23ps ----NEILAQAFIFFVAGFETSSTTMGFALYELAQNQD-TQDKLRNEINDVLAKHN---- 340

6a20ps ----NELAAQAFIFFLAGFDTSSTSLGFALHELAVNQD-IQDKLRTEIDTVMAKHN---- 341

6a20m ----NEIAAQAFIFFLAGFETSSTTMGFALYELACHQD-IQDKLRTEINTVLKQHN---- 353

6a19m ----NEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQD-VQDKLRAEIDSVLERYN---- 343

6a22m ----EEMAAQAFIFFAAGFDTSASTLGFALYELAKQPA-LQAKLREEIDQALRLHN---- 336

6A22ps ----EEMAAQAFIFFAAGFDTSASTLGFALFELARQPQ-LQDKLRQEIDAALQLHQ---- 336

6a13m ----EQIAAQALVFFLAGFDTSSTTMSFCLYELALNPD-VQERLRVEVLAVLKRNN---- 333

6A13ps ----EQIAAQAMVFFLAGFDTSSTTMSFCLYELALNPD-VQDRLRSEILEVLAKNN---- 333

6a14m ----EQMAAQAFVFFVAGFETSSSTMSLCLYELALQPD-IQQRLREEIESVLANVDG--- 362

6A14ps ----EQMAAQAFVFFLAGFETSSSTMAYCLYELAQHPD-IQRRVREEIDAVLKNVEG--- 343

6a15pm ----EQMAAQAIVFFLAGFETSSSTMSSCKYELALQPE-INQIR----DEIERVLEG--- 113

6a16m ----EQMAAQAFVFFVAGFETSSSNMSYALFELAKNQD-VQQKLRMEINDSIGKHG---- 358

6A16ps ----EQLTAHAFDFFVSGYETSSSTMSCALFELAKHPS-VQQKLRNEITGILHKHAP--- 335

6u1m ----IEIAGQAFGFVLAGLGPLNATLAFCLYELARQPE-VQDRTRLEINKALEEHG---- 325

6u1ps ----VQIAAQAFGFVLAGLVPLNATLSFCLYELARQPE-LQDRVRAEIRKTLEQHS---- 327

317a1m ----NELAAHAVVFLKAGYEQTANTLSYVLYELALHPE-LQVRVREEVKKAIERHD---- 358

317a1ps ----NELAAHAVVFLKAGYEQTANTLSYILYELAIHTD-VQATVREEIKKAMERHD---- 358

6g1m ----DFLVAQAGVFFTAGFETSSSTMSFALYEMAKHPE-MQKRLRDEINEALVEGGG--- 351

6G1ps ----DFLVAQAGVFFTAGFETSSSTMSFALYELAKNSH-LQTRLRQEINEALVEGGG--- 353

6w1m ----DYLVAQAAVFQTAGFETSASTMTMTLYELAKNEA-LQDRLRQEIVDFFGDED---- 343

6w1ps ----DYLVAQAAVFQTAGYETSSSTMTLALYEVAKNEE-IQNRLRQEIEEYFGDDD---- 345

6v1m ----DFLAAQAASFEVAGIETCSASMSFALYELAKQPL-MQSRLRREIREAFASNPN--- 357

6v1ps ----DFLAAQAASFEVAGIETCSSSLSFALYELAKQPL-MQARLRREIRETFEESPA--- 358

6g2m ----DILVAQAVLFFTAGFESSSSTMAFAMYELAKDTD-VQQRLREEIKDALVESGG--- 355

6g2ps ----DILVAQAVLFFTAGFESSSSTMAFAMYELAKDAD-IQLRVRHEIKEALIASGG--- 355

6t1m ----DFFAAQAAFLLLAGFDTSSSTITFALYELAKNTT-IQDRLRTELRAALQSSQD--- 364

6t2pm ----DFYVAQAAFLLLAGFDTSS---SFALYELAKNPT-IEHRLQAELRVDLQSSHN--- 324

6t1ps ----DFFVAQASFLLLAGFDTSSSTITFALYELAKAPA-IQKRLRDELSDALRTNRH--- 368

6t3m ----DFVASQAGIILLAGFETSSALMGFTLYELAKAPD-IQERLRSELREAFISTAT--- 339

6t3ps ----DFIASQASIILLAGFETSSALLGFTLYELAKQPD-LQKRLREELAEAFSLAPT--- 340

9b1m ----DEIVAQCFIFFFAAFENNSNLICTTAYELLRNLD-IQERLYEEVKETQEALKG--- 343

9b2m ----DEIVAQCFIFFFAAFENNSNLICTTTYELLYNPD-VQERLYEEIVETKKALNG--- 343

9B2ps ----DEIVAQCFIFFFAAFENNANLICTTSLELLENPD-IQQRLYEEAKEVQESLKG--- 343

9f2m ----RDIVAQCFVFFFAGFETSAVLMCFTAHELMENQD-VQQRLYEEVQQVDQDLEG--- 356

9f3pm ----RDIVAQCFVFFFAGFETSAVLMCFTAHELMENQD-VQQRLYEEVQQVDQDLEG--- 356

9F2ps ----RDIVAQCFVFFFAGFETSAVLMCFTAQELMENED-VQQKLYEEVQQVDIDLDG--- 357

9c1m ----DDLLAQCLLFFSAGFETVATCLSFTSYELMMNPE-VQEKLLAEILAVKEQLGE--- 358

9c1ps ----EDLLAQCLLFFSAGFDTVATCLSFTSHELLMNPE-AQDKLYEEIMATEEQLGG--- 361

9h1m ----DDLLAQCLLFFFAGFEIISSSLCFLTHELCLNPT-VQDRLYEEIISVHEELKG--- 358

9h1ps ----EDLLAQCLLFFFAGFQIISSALCFLSYELCMNPE-VQSELYSEILSVDRELDG--- 358

6d2m ----EKIAAQAFLFYVAGSESTAAASAFTLYELSMYPE-LLKEAQEEVDAVLMKHNLKP- 355

6d2ps ----EKIAAQAFLFYVAGSESTAAAAAFTLYELAMYPE-LLKEARDELDTVLQRHNLEG- 359

6d4m ----EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPE-LLKRLQDEVDETLAKN----- 355

6d4ps ----ESITAQAFIFYIAGQETTGSTAAFVLFELAQYPE-LLERLQTEVDETLAKN----- 355

6d5m ----DLIAGQLFLFYVAGYETTASTTSFTLYELTQNPE-VMEKAKEDVRSAIEKH----- 351

6D5ps ----DLIAGQLFLFFVAGYETTASTAAYTIYELTQNPE-VMARALEDVRSTLEKH----- 351

310a1m ----KRLAKVAEDLLKVSLDAVASTVTFTLLEILQEPL-IVEKLRAEIKELSNEN----- 320

310a1ps ----KRVAKVAEDLLKVSLDSISSNITLTLFEILQEPL-IVEKLQTEIKELSNEN----- 321

28a5m ----RQLLAYSMTFLLDGFETTATVLAHILLNLGRNKE-AQNLLREEIRSHLQ------- 342

28A5ps ----RQLLAHTMTFLLDGFETTATVLAHMLLLLGREPE-AQKRLREEILAHVK------- 342

28d1m ----AELTSHTMTFLTDGFETTAQVLTHTLLFLARNPK-EQMKLREEIG----------- 337

28d1ps ----TELTSHTMTFLTDGFETTALVLSHTLLLLGRNPA-EQRKVRDEIG----------- 336

28d2m ----DNILINTMTFILDGFETTALVLAHIMLMLGRNPE-EQDKVRKEIG----------- 336

28c1m ----EDMASHAMTFMFDGLDTTSNSIAHCLLLLGRNPD-CQRRLYEELQLVNP--G---- 336

28c1ps ----PQLTSHAMTFMFDGLDTTSSTISHCLLLLGRYPE-CQQRLYEELDKASP--S---- 336

309a1m ----HDSVGHALTVHLDGFETSGAVLYHMLYSLSEHHE-EQEKLRSEILEALA--S---- 345

309a1ps ----TDAVGHALTVLLDGYETSAAVLYHMLYTLSEHPE-EQEKLRSELVEALA--A---- 345

309a2m ----DDLVGHALTVMLDGYDTSGTALLHALYYLAENPA-VQQKLRVEILSCMA--S---- 345

309a2ps ----DDLVGHALTVMLDGYDTTGTALLHALYYLAENPA-AQQKLRMEILQSLD--A---- 348

308a1m ----EELAGHATTLLLEGYETSAMLLAFALYELALNED-AQRRLHIELDEVAQRHA---- 325

308a1ps -----DLAGHATTLLLEGYETSAMLLAFALYELSRNES-AQRRVQTELEEVAQRHG---- 332

4aa1m ----EDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPE-CQDRCVLELATIFE--DS--- 353

4aa1ps ----QDIVNEACTFMLAGQDSVGGAVAFTIFLLAQNAE-CQEQCHEELERIFD--YS--- 365

4C3m ----EDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPE-YQERVVEELDSIFG-DDK--- 380

4C3ps ----EDIREEVDTFMFEGHDTTSAAISWTLFLLGCHPE-YQEQVAEELDSIFG-NDK--- 379

4d1m ----LDIREEVDTFMFEGHDTTSSALMFFFYNIATHPE-AQKKCFEEIRSVVG-NDK--- 354

4D1ps ----LDIREEVDTFMFEGHDTTSSALMFFFYNVATHPE-AQKKCFEEISSVIG-QDK--- 357

4d1malt ----LDIREEVDTFMFEGHDTTSSALMFFFYNIATHPE-AQKKCFEEIRSVVG-NDK--- 345

4D1psalt ----LDIREEVDTFMFEGHDTTSSALMFFFYNVATHPE-AQKKCFEEISSVIG-QDK--- 358

4s3m ----TDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPD-VQQRAFEEASELEG-REK--- 345

4s3ps ----RDIREEVDTFMFEGHDTTSSAIAFALSLLSKHSE-VQQRAYEEARDLEG-REK--- 346

312a1m ----KDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPE-HQQRCREEVWSVCG-KDK--- 354

312a1ps ----KEIREEVDTIIFGGFDLTATVLKFVMYNMTLHTD-HQQQCREEIWQICG-KDT--- 355

4g1m ----KDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKD-IQAKVFAEQKAIFG-DNM--- 394

4G1ps ----KDIIDEVNTIMFEGHDTTSAGSSFALCMMGIHKD-IQEKVFAEQKAIFG-DNM--- 390

4g15m ----TEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQD-IQDRVLAELDSIFG-D-S--- 416

4G15ps ----TEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQE-IQDRVIAELDGIFG-D-S--- 416

4d2m ----EDIREEVDTFMFEGHDTTTSAISFCLYEISRHPE-VQQRLQQEIRDVLG-EDR--- 349

4D2ps ----DDIREEVDTFMFEGHDTTTSAISFCLYEISRHPQ-VQQLLVEEIHEVLG-VDR--- 353

4d14m ----DDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPE-VQARVFQEVRDVIG-DDK--- 353

4d14ps ----EDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPE-VQARVFQEVRDVLG-DEK--- 355

4d8m ----DEIREEVDTFMFEGHDTTTSALSFCLHELSRHPE-VQAKMLEEIVQVLG-TDR--- 347

4d8ps ----DEIREEVDTFMFEGHDTTTSALSFCLHVLARHPQ-VQEKMLEEILRVIG-TDR--- 348

4ae1m ----KQIRDEVNTFIFEGHDTTTSAVSFCLYLLSRHEA-VQQKLFEELRMHYG-QDL--- 342

4AE1ps ----KQIRDEVNTFIFEGHDTTTSAISFCLYLLSRHAA-VQERLFDEVKGHFG-REL--- 347

4d20m ----ADIREEVDTFMFEGDDTTSSGVSHALYAIARHPE-VQQRIFEELQRVLG-PDA--- 354

4D20ps ----ADIREEVDTFMFEGDDTTSSGVSFALYAIARHPQ-VQARIYRELLQVLG-RDP--- 355

4d21m ----VDIREEVDVFIFAGDDTTTSGVSHALHAISRHPK-VQECIYEELVSVLG-PDP--- 354

4e2m ----KELYEEVSTFMFEGHDTTTSGVSFAVYLLSRHQD-EQRKLFKEQREVMGNSEL--- 346

4e2ps ----QELYEEVSTFMFEGHDTTTSGVSFAVFLLSRHKD-EQRKLFDEQREVMGDSGM--- 346

4e1m ----QELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPD-EQEKLFNEQCDVMGASGL--- 346

4e1ps ----QELYEEVSTFIFAGHDTTTSAISFTLYLVSRHQDDEQRKLFEEQRDVMGDSGL--- 347

4e3m ----QEIYEEVSTFMFEGHDTTTSGVSFSVYLLSRHPD-VQRKLYREQCEVMG-HDM--- 345

4e3ps ----QEIYEEVSTFMFEGHDTTTSGVAFAGYLLSRHPE-AQQRMYQEQCNVMG-SEL--- 345

4ad1m ----REIIEEVSTFIFTGHDPIAAAISFTLYTLSRHSE-IQQKAAEEQRRIFG-ENF--- 343

4AD1ps ----REIIEEISTFIFAGHDPVAAAISFTLYTLSRHTE-IQQRVFEEQQRIFG-QDL--- 344

4p1m ----IGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPD-KQELCYQEIQEHIDDD----- 357

4p3m ----IGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPE-EQEKCYQEIQANIDDE----- 359

4p1ps ----AGICEEVDTLMFEGYDTTSIGLIFSLMNMSLYPE-KQELCYKEIEEHIDDS----- 360

4P2ps ----AGICEEVDTLMFEGFDTTSIGLIFSLMNMSLYPE-KQELCYKELEEHIDDN----- 361

4P3ps ----AGICEEVDTLMFEGYDVSSITLIFTLMNMSLYPD-KQELCFKEIQEHIEDD----- 361

4p2m ----IGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAA-EQELCYQEIQEHILDD----- 362

4ac1m ----QGICDEVNTFMFEGYDTTSTCLIFTLLMLALHED-VQKKCYEEVENLPED------ 353

4AC1ps ----QGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEE-VQERCLEEVSTLPED------ 353

4ac2ps ----QGICDEVNTFMFEGYDTTSTCLIFTLLMLSLHKD-VQERCLEEVSALPED------ 354

4ac2m ----QGICDEVNTFMFEGYDTTSTCLIFTLLMLALHED-VQKKCYEEIKYLPDD------ 354

4ac3m ----QGICDEVNTFMFGGYDTTSTSLIFTLLLLALHAD-VQERCYEELQDLPED------ 353

311a1m ----REIRDEINTFVFAGVDTTTAAMSFVLYALAKFPE-TQTRLRKELQDVAL------- 328

311a1ps ----KEIRDEINTFVFAGVDTTTAAMSFVLYALAMNPE-AQDRLQEELRQLPP------- 277

316a1m ----EEICGELNTCNYLGYQLCSPALCFCLVTIARNPS-VQQKCLDELNLAQI------- 335

316A1ps ----DDICAELNTCNYLGYLLCSSALCFSLVTISRHPA-VQQRCLEELRKAQR------- 340

313a2m ----MELGAECSSMVLAAFETSAHTVYYALVLLAMFPE-HQEMVFNEIKEHFPLAKG--- 336

313a3m ----EEVQSECCSFVVAAFETTGDTVYHALILLAMFPE-HQDTVYQELKELFPVAGD--- 336

313a1m ----MDVKSECCIMIAAGYDTSALTVYHALFLLANHPE-HQEAVFEELNGVFPDAGH--- 336

313C1ps ----EDVKSECILTIVAGFETSAITVFNTLILLAMFPE-YQETAFEELKDVFPHVGD--- 337

313C2ps ----EDAEGECSIMVGASFETTAVTVFSTLTFLAMFPE-YQDAAFVELKDVFPNAGD--- 337

313a5m ----DDVMGEFSNIIFAASDTLSITVNNVLILMAMFPK-YQDNVFEELAEVFPSGGE--- 331

313a4m ----KNVEDESNIIVFGAFETTANAVYYTLMLLAMFPE-YQERAFEEIKTIFPNTGD--- 338

313a4ps ----KNVEDESNIIVFGAFETTANTVYYVLMLLAMFPQ-YQERAFEEIKSLFPNSGD--- 335

313A4bps ----TNVEDESNQVVFGAFETTAKTVYYVLMLLAMFPQ-YQEKVFEEIKSLFPDSGD--- 333

313b1m ----QDVRDEANVTIAATFETTSTALYFTILCLAMHPC-YQEKLHKELVTELPPSG---- 345

313b1ps ----QDVRDEANVTIAATFETTSTALYFTILCLAMHPT-YQEKLHKELVAELPPNG---- 344

318a1m ----EEIMDEAQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVG---- 354

318A1ps ----QEIEDEAQSMVLVSFETVSNSIMLALLCLATHKGDCQQRLRAEIASVFPGQGQGST 356

18a1m KNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPK-EMRRVQDELDQVVGRH----- 365

18a1ps KNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPK-EMRRVQDELDQVVGRH----- 366

306A1m LYCDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREQR-CQRRLHELLLPLG-------- 404

306A1ps LYCDEQLRHLLADLFGAGVDTSLATLRWFLLYMAREQS-SQRRLHELLLPLS-------- 422

303a1m ----QSLLAICLDMFLAGSETTNKSLGFCFMHLVLQPE-IQERAFQEIKEVVGLE----- 347

303A1ps ----ESLLAICLDMFLAGSETTNKSLGFCFMHLVLRPD-IQERAYTEIKEVVGLE----- 347

305a1m ----TQLVMTILDFFIAGSQTTSNTINLALMVLAMRPD-VQEKLFSQVTASVAAA----- 346

305A1ps ----TQLVMTILDFFIAGSQTTSNTINLALMVLAMRSD-VQEKLFAEVSANVNSA----- 348

304a1m ----DQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPA-VLRRVQNEIDEVVGCG----- 352

304a1ps ----DQFIMGLLDFSIPAFTAVGVQLTLLIQYLMLYPS-VMERIQQEIEEVVGCG----- 352

307a1m ----N-TIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVD-IGRRIQEEIDAIIEEE----- 363

307a1ps ----N-TIIFMLEDFIGGHSAVGNLVMLALAYIAKNPQ-VGRRIQDEVDAVSSKG----- 358

307a2pm ------------------------------------------------------------

307a2pps ----N-TIIFMLEDFIGGHSAVGNLVMLALAYIAKNPM-IGRRIEHEADIVTNKG----- 358

11C

11A 11B 11D 11E

12a4m ---E-FTEASM---KNVPYLRACIKESQRLHP-LIVGNARVLARDAVLSG-- 414

12a5m ---E-FTEASM---KNVPYLRACIKESQRVYP-LVIGNARGLTRDSVISG-- 414

12A4ps ---E-FTEASM---KNVPYLRACIKESQRLYP-LVIGNIRVLNRDSVLSG-- 413

12A5ps ---E-FTEASM---KNVPYLRACIKESQRIYP-LVIGNGRVLNRDSVLSG-- 413

12c1m ---E-FTVEDM---KSLPYLRAVIKESLRLYP-VTFGNARSAGADVVLDG-- 404

12c1ps ---Q-FTLAEM---KSLPYLRACIKESMRMFP-VTFGNIRSAGTDVVLDG-- 413

12e1m ---S-LTIENM---RNLPYLRACIKEGIRMYP-IGPGTLRRMPHDVVLSG-- 397

12e1ps ---P-LTIENM---SNLPYLRACIKEGIRLYP-IGPGTVRRMPHDVVLSG-- 400

12d1m ---L-LNEENM---KDMPYLRAVIKETLRYYP-NGLGTMRTCQNDVILSG-- 406

12d1ps ---L-LNEDTM---RDMPYLRAVIKETLRFYP-NGLGTLRSCPTGVTLSG-- 406

12b2m ---S-LTDQNT---KNMPYLRACIKEGLRITS-ITPGNFRITPKDLVLSG-- 412

12B2ps ---S-LTDEST---KNMPYLRACIKEGLRITS-ITPGNFRITTKDLVLSG-- 415

49A1m ---D-INQNVL---EQMPYLRACVKETLRMRP-VVIANGRSLQSDAVING-- 470

49A1ps ---E-INQNVL---EQMPYLRACVKETLRMRP-VVIANGRSLQSDAVING-- 475

301a1m ---P-LTIPLL---DQMHHLKGFIKEVFRMYS-TVIGNGRTLMEDSVICG-- 441

301A1ps ---P-LTIQLL---DQMHHLKAFIKEVFRMYS-TVIGNGRTLQEDSVICG-- 446

302a1m ---ELSMDALR---TDITYTRAVLKESLRLNP-IAVGVGRILNQDAIFSG-- 378

302A1ps ---PLSADALR---TDITYTRAVLKESLRLNP-ISVGVGRVLNQDTVLSG-- 376

314a1m -----ILQDAL---TNATYTKACIQESYRLRP-TAFCLARILEEDMELSG-- 426

314a1ps -----ILQDAL---TNATFTKACIQESYRLRP-TAFCLARILEEDMELSG-- 427

315a1m ----------------R-LMHGLIKESLRLYP-VAPFIGRYLPQDAQLGG-- 408

315a1ps ----------------Q-LLHGLIKESLRLYP-VAPFIGRYLPQDAHLGD-- 410

6a2m ---GQLTYESI---KAMTYLNQVISETLRLYT-LVPHLERKALNDYVVPG-- 391

6a2ps ---GKLTYECV---KEMRYLDQVFSETLRLYT-LVPHLERRALSDYVVPG-- 391

6a8m ---QNFTYECT---KDLKYLNQVLDETLRLYT-IVPNLDRMAAKRYVVPG-- 391

6a18m ---QKFTYECI---KDLKYLDQVINETLRHYT-IVPNVDRVAAKRFVVPG-- 391

6a8ps ---QKFTYEST---KDLKYLEQVIFETLRLHT-IVPHLDRMAHKRYVVPG-- 390

6a9m ---GEITYESM---KDMVYLDQVISETLRLYT-VLPVLNRECLEDYEVPG-- 389

6a21m ---GELNYESM---KDLVYLDQVVSETLRLYT-VLPVLNRECLEDYEVPG-- 389

6a21ps ---GELTYESM---KELVYLDQVISETLRLYT-VLPVLNRECLEDFVVPD-- 391

6a17m ---KEFTYEGI---KEMKYLEQVVMETLRKYP-VLAHLTRMTDTDFSPE--- 384

6a23m ---NEFTYEGI---KEMKYLEQVVMETLRKYP-VLAHLTRMTQTDFSPE--- 385

6A17ps ---NQFTYEGI---KEMKYLEQVVMETLRKYP-ALGHLTRKTRLDFSPE--- 383

6A23ps ---NQFTYEGI---KEMKYLEQVVMETLRKYP-VLAHLTRKTQADFSPE--- 382

6a20ps ---GQLNYDSM---RELTYLDKVIDETFRKNP-VVGHLIRICTQRYEHP--- 383

6a20m ---GKLDYDSM---REMTYLEKVIDETMRKRP-VVGHLIRVATQHYQHT--- 395

6a19m ---GKLEYDSM---QDLFYMEKVINESLRKHP-VVAHLARIATKPYQHS--- 385

6a22m ---GEFTYDSM---QELRYMELVIAETLRKYP-ILPQLTRISRHLYAAKG-- 379

6A22ps ---GQFTYDSM---QELRYMELVIAETLRKYP-PLPHLTRISKNLYTAKG-- 379

6a13m ---QKLTYDSV---QEMPYLDQVVAETLRKYP-ILPHLLRRSTKEYQIP--- 375

6A13ps ---HQLTYESI---QEMPYLDQVVAETLRKYP-ILPHIVRQTTKKYDVP--- 375

6a14m ---GELNYDVL---AQMTYLDQVLSETLRKHP-LLPHLIRETTKDYQIP--- 404

6A14ps ---GEITYDAL---AEMNYLEKVLAETLRKHP-IVPQLIREANQNYKVP--- 385

6a15pm ---NAITYDAL---AKINYPEQVLSETLRKH--QLIKFLLETQESFRVR--- 164

6a16m ----KLTYEAM---MEMPYLDQTITETLRKYP-ALSSLTRLASEDYEIPSPD 402

6A16ps ----NLTYEAV---QEMRYLDQTITETLRKYP-ALASLTRIAAEDYTVPTAS 379

6u1m ---GQVTPECL---RELRYTKQVLNETLRLHT-PHPFLLRRATKEFEVPGS- 369

6u1ps ---GQLTTEGL---KELLYTKQVLNETLRLHT-PYPFLLRRATKEFELPGS- 371

317a1m ---GHITHEGI---KSLSFMGQVINETLRMHP-ITPYILRRTLNDYAVPDHP 403

317a1ps ---NNLNYECV---QSLAYLGQVINETLRVHP-ITPYILRRTLTDYQVPDHP 403