172 sequences intron locations are coded phase 00, phase 1, phase 2

12a4m ------------------------------------------------MLKVRSALSLIQ 12

12a5m ------------------------------------------------MLKGRIALNILQ 12

12A4ps ------------------------------------------------MLKVRTGLSIIQ 12

12A5ps ------------------------------------------------MLKVRSGLSIIQ 12

12c1m ------------------------------------------------MLRLTV-KHGLR 11

12c1ps ------------------------------------------------MIRRAVVQQGIR 12

12e1m --------------------------------------------------MLSTQWNANK 10

12e1ps --------------------------------------------------MLSQQLNAKR 10

12d1m -------------------------------------------------MNTLSSARSVA 11

12d1ps ------------------------------------------------MNAWQSLTRRLA 12

12b2m ---------------------------------------MWKYSNKIIYRNVSGNQLWFN 21

12B2ps ---------------------------------------MWKNTMKTVRRQSAAHQLFNA 21

49A1m MSGLRKTSIALMRRSTSS----TTILPHSG---GVGGAVSPPSSGVGVATEIEKSIAMQR 53

49A1ps MSGLRKTSFALMRRSTYSGSATATMLPHAGPGPGTGVDGAAPPSGVGVATEIEKSIARQR 60

301a1m ---MNNLSLKAWRSTVSC----G----------PNLRQCVPRISGAGSR-----RAQCRE 38

301A1ps ------MNKLPVRACTAS----A----------SSLRRTVSRISGSGLLPNEKQRLEIRD 40

302a1m ------------------------------------------------------------

302A1ps ------------------------------------------------------------

314a1m ------------------------------------MAVILLLALALVLGCYCALHRHKL 24

314a1ps ------------------------------------MAVILLLALALVLGCYCAIHRHKI 24

315a1m ----------------------------------------------MTEKRERPGPLRWL 14

315a1ps ------------------------------------------------MNRKRTSLLHWL 12

6a2m -----------------------------------------------------------M 1

6a2ps -----------------------------------------------------------M 1

6a8m --------------------------------------------------------MALT 4

6a18m --------------------------------------------------------MQLT 4

6a8ps --------------------------------------------------------MGVT 4

6a9m --------------------------------------------------------MGVY 4

6a21m --------------------------------------------------------MSVG 4

6a21ps ------------------------------------------------------MAVGVG 6

6a17m ------------------------------------------------------------

6a23m -----------------------------------------------------------M 1

6A17ps -----------------------------------------------------------M 1

6A23ps -----------------------------------------------------------M 1

6a20ps -----------------------------------------------------------M 1

6a20m -----------------------------------------------------------M 1

6a19m -----------------------------------------------------------M 1

6a22m -----------------------------------------------------------M 1

6A22ps -----------------------------------------------------------M 1

6a13m -----------------------------------------------------------M 1

6A13ps -----------------------------------------------------------M 1

6a14m -----------------------------------------------------------M 1

6A14ps ------------------------------------------------------------

6a15pm ------------------------------------------------------------

6a16m -----------------------------------------------------------M 1

6A16ps -----------------------------------------------------------M 1

6u1m -----------------------------------------------------------M 1

6u1ps --------------------------------------------------------MDLL 4

317a1m -------------------------------------------------------MWIIF 5

317a1ps -------------------------------------------------------MWIIF 5

6g1m ------------------------------------------------------------

6G1ps ------------------------------------------------------------

6w1m ------------------------------------------------------------

6w1ps ------------------------------------------------------------

6v1m -----------------------------------------------------------M 1

6v1ps -----------------------------------------------------------M 1

6g2m ------------------------------------------------------------

6g2ps ------------------------------------------------------------

6t1m ------------------------------------------------MIAVFSLIAAAL 12

6t2pm -----------------------------------------------MVIAFFIFLCAAL 13

6t1ps -------------------------------------------MILVIGVLFIAATVAAI 17

6t3m -----------------------------------------------------------M 1

6t3ps -----------------------------------------------------------M 1

9b1m ----------------------------------------------------------MS 2

9b2m ----------------------------------------------------------MA 2

9B2ps ----------------------------------------------------------MV 2

9f2m -----------------------------------------------------------M 1

9f3pm -----------------------------------------------------------M 1

9F2ps -----------------------------------------------------------M 1

9c1m ----------------------------------------------------------MV 2

9c1ps ----------------------------------------------------------MA 2

9h1m ---------------------------------------------------------MDQ 3

9h1ps ---------------------------------------------------------MEK 3

6d2m ------------------------------------------------------------

6d2ps -----------------------------------------------------------M 1

6d4m -----------------------------------------------------------M 1

6d4ps -----------------------------------------------------------M 1

6d5m ------------------------------------------------------------

6D5ps ------------------------------------------------------------

310a1m ------------------------------------------------------------

310a1ps ------------------------------------------------------------

28a5m ----------------------------------------------------------MV 2

28A5ps ----------------------------------------------------------MI 2

28d1m --------------------------------------------------------MCPI 4

28d1ps --------------------------------------------------------MCPI 4

28d2m --------------------------------------------------------MCPV 4

28c1m ----------------------------------------------------------MF 2

28c1ps ----------------------------------------------------------MI 2

309a1m -------------------------------------------------------MFTLV 5

309a1ps -------------------------------------------------------MWTTV 5

309a2m -------------------------------------------------------MYILA 5

309a2ps -------------------------------------------------------MYILV 5

308a1m ------------------------------------------------------------

308a1ps -------------------------------------------------------MLLLL 5

4aa1m -------------------------------------------MHLRLLSPPQLERTTNL 17

4aa1ps ------------------------------------------MQFYTRMTVPQLERATRT 28

4C3m ---------------------------------MSSKVITSLMAESILLSKVGQVISGYS 27

4C3ps ---------------------------------MSSKVISSLMAESILLTKMAQVISGYS 27

4d1m ---------------------------------------------------------MFL 3

4D1ps ---------------------------------------------------------MFL 3

4d1malt ---------------------------------------------------------MWL 3

4D1psalt ---------------------------------------------------------MWL 3

4s3m --------------------------------------------------------MSTL 4

4s3ps --------------------------------------------------------MNTW 4

312a1m ---------------------------------------------------------MFW 3

312a1ps --------------------------------------------------------MVVW 4

4g1m ----------------------------------MAVEVVQETLQQAASSSSTTVLGFSP 26

4G1ps ----------------------------------MTVDTVQETLQHAATS--TSGLGFSP 24

4g15m ------------------------------------MEVLKKDAALGSPS--S------- 15

4G15ps ------------------------------------MEVLKKDAAMGSPS--S------- 15

4d2m ------------------------------------------------------MLGVVG 6

4D2ps --------------------------------------------------------MLAL 4

4d14m ---------------------------------------------------------MYL 3

4d14ps ---------------------------------------------------------MFV 3

4d8m ----------------------------------------------------------ML 2

4d8ps ----------------------------------------------------------ML 2

4ae1m --------------------------------------------------------MLVV 4

4AE1ps --------------------------------------------------------MLMA 4

4d20m ---------------------------------------------------------MWL 3

4D20ps --------------------------------------------------------MLLL 4

4d21m ---------------------------------------------------------MWI 3

4e2m -------------------------------------------------------MWFVL 5

4e2ps -------------------------------------------------------MWFVL 5

4e1m -------------------------------------------------------MWIVL 5

4e1ps -------------------------------------------------------MWFAL 5

4e3m -------------------------------------------------------MWLAV 5

4e3ps -------------------------------------------------------MWLAV 5

4ad1m -------------------------------------------------------MFLIA 5

4AD1ps -------------------------------------------------------MFLIA 5

4p1m -------------------------------------------------MIILWLILALS 11

4p3m -------------------------------------------------MLILWLVGAFI 11

4p1ps -------------------------------------------------MIVFLLTVALC 11

4P2ps -----------------------------------------------TMIVVLWLTVALC 13

4P3ps -------------------------------------------------MITLWLTVALC 11

4p2m -----------------------------------------------MMICLLWISVAIL 13

4ac1m ------------------------------------------------MWIALLGIPILL 12

4AC1ps ------------------------------------------------MLIALLGTPLLL 12

4ac2ps ------------------------------------------------MFELLLGVPLIV 12

4ac2m -----------------------------------------------MFLEVLFAAPLVI 13

4ac3m ------------------------------------------------MWIALLGSSLLI 12

311a1m -----------------------------------------------------------M 1

311a1ps ------------------------------------------------------------

316a1m ---------------------------------------------------------MIL 3

316A1ps ---------------------------------------------------------MIL 3

313a2m ----------------------------------------------------------MI 2

313a3m ----------------------------------------------------------MD 2

313a1m ----------------------------------------------------------ML 2

313C1ps ----------------------------------------------------------MY 2

313C2ps ----------------------------------------------------------MI 2

313a5m ----------------------------------------------------------ML 2

313a4m ----------------------------------------------------------ML 2

313a4ps ----------------------------------------------------------ML 2

313A4bps ----------------------------------------------------------ML 2

313b1m ----------------------------------------------------------ML 2

313b1ps --------------------------------------------------------MLLG 4

318a1m ----------------------------------------------------------MH 2

318A1ps ----------------------------------------------------------MH 2

18a1m -------------------------------MLADSYLIKFVLRQLQVQQ-DGDAQHLLM 28

18a1ps -------------------------------MLADSYLIKFLLRQLQVQQQDAGAQHLLM 29

306A1m -------------------------------------MSADIVDIGHTGWMPSVQSLSIL 23

306A1ps --------------------------------MSASFATASASASVFDWLPLSGHSFCLL 28

303a1m ----------------------------------------------------------MF 2

303A1ps ----------------------------------------------------------MF 2

305a1m --------------------------------------------------------MSAL 4

305A1ps --------------------------------------------------------MSAL 4

304a1m --------------------------------------------------------MITE 4

304a1ps --------------------------------------------------------MLTE 4

307a1m -------------------------------------MLAALIYTILAILLSVLATSYIC 23

307a1ps ---------------------------------------MSAVYSVLAILLAIIITSYIR 21

307a2pm -------------------------------------MLTSVFYVLFAIAITIILISYVF 23

307a2pps -------------------------------------MFFSVCYLIIAIGITAIVISYIL 23

2A 2B 2C 2D 2E

12a4m SQKATLSLATQKR----WQTNVATAEARE--------DSEWLQAKPFEQIPRLN---MWA 57

12a5m SQKPIVFSASQQR----WQTNVPTAEIRN--------DPEWLQAKPFEEIPKAN---ILS 57

12A4ps AQKAALSVSCPLR----WQTTAAVAEPRN--------DEEWLQARPFKQIPST----TFL 56

12A5ps AQKAALSVSSPLR----WQTTAAVAEPRN--------DEEWLQARPFEQIPST----TFL 56

12c1m ANSQLAATRNPD---------ASSYVQQL--------ESEWEGAKPFTELPGP----TRW 50

12c1ps ARSSLAEVQVISKKNLDPAAASSSYMEQL--------EGEWSTAKPFEEIPGP----TRW 60

12e1m QISRQIYQLCR--------------------------VLNLEEAKPYADIPGP----SKL 40

12e1ps QASCQIYQIYRNE------------------------TISLEQAKPYAEVPGP----SKF 42

12d1m IYVGPVRSSRSAS--------VLAHEQAK--------SSITEEHKTYDEIPRP----NKF 51

12d1ps VATGPIRSLRGSS--------AQAQAQRS---------VEDVEARPFSEVPRP----GRL 51

12b2m RNSSVGGTLSQQT----QLELADS---RI--------DEKWQQARSFGEIPGP----SLL 62

12B2ps RDLSLNRTLGQQT----HLELLDKSPPRT--------DERWQQAKSYGELPGP----NGW 65

49A1m LRTGESSNPKKLNVSQQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIG 113

49A1ps LRQGQSETAKKLNVSHLAATAVPATETAT--ATATRTASPTAGVRPYSEVPGPYPLPLIG 118

301a1m SSTGVATCPHLADSEEASAP---RIHSTS----------EWQNALPYNQIPGPKPIPILG 85

301A1ps SSTGVAACPHLLEPEETAAPTTPRIHSTP----------EWQNALPYNQIPGPKPLPILG 90

302a1m ---MLTKLLK------------ISCTSRQC-----------TFAKPYQAIPGPRGPFGMG 34

302A1ps ---MLTKLLK------------ISCTSRQC-----------TFAKPFEAMPGPRGPWGLG 34

314a1m ADIYLRPLLKNTLLEDFYHAELIQPEAPK------------RRRRGIWDIPGPKRIPFLG 72

314a1ps GATYLKPLLKNTPLEDCYHATPVVPEQQKS-----------RRRRSIWDIPGPQRIPFLG 73

315a1m RHLLDQLLVRILSLSLFRSRCDPPPLQRFP-------ATELPPAVAAKYVPIPR-VKGLP 66

315a1ps QQLLRTLLVRLLCQFKSKAGLTKATAG-----------SNRCRSKGGEIVPIPR-VKGLP 60

6a2m FVLIYLLIAISS---------LLAYLYHRN---------FNYWNRRGVPHDAP--HPLYG 41

6a2ps LILIYLVIAVGS---------LVAYLLHRN---------FQYWKRKGVPHDPP--HPFYG 41

6a8m YILFQVAVALLA---------ILTYYIHRK---------LTYFKRRGIPFVAP--HLIRG 44

6a18m YFLFQVAVALLA---------IVTYILHRK---------LTYFKRRGIPYDKP--HPLRG 44

6a8ps YVLLQVAVALLA---------IVTYYVYRR---------LSYFKSRGIPHDTP--HLILG 44

6a9m SVLLAIVVVLVG---------YLLLKWRRA---------LHYWQNLDIPCEEP--HILMG 44

6a21m TVLLTALLALVG---------YLLMKWRST---------MRHWQDLGIPCEEP--HILMG 44

6a21ps ALLLWTLVALVV---------YLLLKWLLG---------RQYWQNLGIPCEEP--HWLLG 46

6a17m MLLLALIVVILS---------LLVFAARRR---------HGYWQRRGIPHDEV--HPLFG 40

6a23m SLLLTLIALLVS---------LLLFMARRR---------HGYWQRRGIPHDVP--HPIYG 41

6A17ps SLVLALIAIVVS---------LVLFAARRR---------HGYWQRRGIPHDVP--HPLFG 41

6A23ps SLVLALIAIVVS---------LVLFAARRR---------HEYWQNLGIPCEEP--HWLLG 41

6a20ps AIIIVLLVGVIS---------LAVWWVHQN---------FSYWKRRGIPHDPP--NIPKG 41

6a20m AVMIVLLIGVIT---------FVAWYVHQH---------FNYWKRRGIPHDEP--KIPYG 41

6a19m AILLGLVVGVLT---------LVAWWVLQN---------YTYWKRRGIPHDPP--NIPLG 41

6a22m LDVVALLLIALA---------VGFWFVRTR---------YSYWTRRGIGSEPA--RFPVG 41

6A22ps LDVIALLLITLA---------IGFWYVRTR---------LSYWARRGIGHVRP--TFPMG 41

6a13m LTLLVLVFTVGL---------LLYVKLRWH---------YSYWSRRGVAGERP--VYFRG 41

6A13ps WTLLALVLVAGA---------LIYSRLLEH---------YDYWRRKGVAGEKP--VLFLG 41

6a14m LFTIALVGVVLG---------LAYSLHIKI---------FSYWKRKGVPHETP--LPIVG 41

6A14ps --------MALA---------LAYNFYRNT---------YSYWERKGVPNERP--LPLIG 32

6a15pm ------------------------------------------------------------

6a16m DFTLLLLTSLLS---------FLLGYLRYR---------FTYWELRGIPQLRP--HFLFG 41

6A16ps GFVLILLTSLLS---------GVLGYLRCK---------YNYWQINGVKQLRA--HFLFG 41

6u1m HRTLLTALGALS---------VVYALVKFS---------LGYWKRRGILHEKP--KFLWG 41

6u1ps HRALLTAVGALS---------LFYALVKVS---------LGYWKRRGILHEKP--KFFWG 44

317a1m LIIGLLVLGLLV---------LLIIAARYQ---------RDYWRYLDIPHERP--KKLWP 45

317a1ps TIIGLVVLGLVI---------LLIMAARYQ---------RDYWHYLNIPHERP--KKLWP 45

6g1m MVLTEVLFVVVA------ALVALYTWFQRN---------HSYWQRKGIPYIPP--TPIIG 43

6G1ps MALTEALFLIVG------ALSAVYIWFQRN---------HSYWQRKGIPYIPP--TPIIG 43

6w1m ---MLLLLLLGS------LTIVFYIWQRRT---------LSFWERHGVKYIRP--FPVVG 40

6w1ps -MSTELLFLIAT------VAIVFYVWHKRR---------HSFWKRHGVKEIGP--LPILG 42

6v1m VYSTNILLAIVT------ILTGVFIWSRRT---------YVYWQRRRVKFVQP--THLLG 44

6v1ps VYSTNILLAIVT------ILTAVFVWSRRT---------YVYWQRRRVKFVQP--AHLLG 44

6g2m -MELVLLILVAS------LIGIAFLALQQH---------YSYWRRMGVREIRP--KWIVG 42

6g2ps -MVLGLFLLVVI------FLATICFLLQQH---------YAYWRRRGVRELRP--HWILG 42

6t1m AVGSLVLLPVVLRGGCLLVVTIVWLWQILH---------FWHWRRLGVPFVP--AAPFVG 61

6t2pm AVGSVVLLPLIA-------LLAVWLWQRRH---------FRIWRRLGVPYLP--AAPVLG 55

6t1ps GLLFFVVFPLVCAAG-LIIFGIIWLWQRHH---------FCHWLRLGVPYIR--ATPFVG 65

6t3m LLIWLLLLTIVT----------LNFWLRHK---------YDYFRSRGIPHLPPSSWSPMG 42

6t3ps VSLWLLMLGILS----------IYLWLRQR---------YSYFERHNIVHLPVSAWTPLG 42

9b1m FVEICLVLATIG--------LLLFKWSTGT---------FKAFEGRNLYFEKP--YPFLG 43

9b2m LIEICLALVVIG--------YLIYKWSTAT---------FKTFEERKLYFEKP--YPFVG 43

9B2ps CLEICLAILVLG--------FMIYKWSTAT---------HRAFDERGVYFEEP--KPFFG 43

9f2m LWEFFALFAIAA--------ALFYRWASAN---------NDFFKDRGIAYEKP--VLYFG 42

9f3pm LWEFLALFAIAT--------ALFYRWASAN---------NDFFKDRGIAYEKP--VLYLG 42

9F2ps LLEFVALLGIAF--------ALFYRWATAN---------NEFFKEKGIPFAKP--KLYFG 42

9c1m FVELSIFVAFIG--------LLLYKWSVYT---------FGYFSKRGVAHEKP--IPLLG 43

9c1ps FEVLLALGALIG--------FLLYKWAEPP---------VRFFLKRGVVHEAP--VPLLG 43

9h1m SMIALALFIILL--------VLLYKWSVAK---------YDVFSERGVSHEKP--WPLIG 44

9h1ps WIVVLSLVAVLL--------VLLYKWSVAK---------YGILTERGVPHAQP--KPLLG 44

6d2m MWTILLTILIAG---------LLYRYVKRH---------YTHWQRLGVDEEP--AKIPFG 40

6d2ps WAILTLLTLALG---------LLYQFVRRH---------YSSWQRLGVDEET--PKIPMG 41

6d4m FSLILLAVTLLT---------LAWFYLKRH---------YEYWERRGFPFEKH-SGIPFG 42

6d4ps FSLIVLAGTLLA---------LGWFYLKHH---------YQYWERRGFPFDRQ-STIPFG 42

6d5m MIGIYLLIAAVT---------LLYVYLKWT---------FSYWDRKGFPSTG--VSIPFG 40

6D5ps MIGILLLVAAVS---------LLYVYLKWT---------FSYWDRQGFPSAG--VTIPFG 40

310a1m -MWLLLPILLYS---------AVFLSVRHI---------YSHWRRRGFPSEK--AGITWS 39

310a1ps -MWLLLPILLYS---------VLFLAVRHI---------YSHWRRKGFPSER--AGISWS 39

28a5m LITLTLVSLVVG---------LLYAVLVWN---------YDYWRKRGVPGPKP--KLLCG 42

28A5ps LITLALGLATVG---------LLYLLMTWN---------FDHWRKRRVPGPKP--KIPTG 42

28d1m STALFVIAAILA---------LIYVFLTWN---------FSYWKKRGIPTAKS--WPFVG 44

28d1ps CAVLLLLATLLT---------LIYIFLTWN---------FGYWKRRGIQTAKA--WPLVG 44

28d2m TTFLVLVLTLLV---------LVYVFLTWN---------FNYWRKRGIKTAPT--WPFVG 44

28c1m GSLLLGIATLLG---------AIYAFLVSN---------FGHWRRRGVTEPRA--LPLFG 42

28c1ps GSLLLAVGALAT---------LVYGFLVWN---------FGHWRARGIKEPRA--LPLLG 42

309a1m GLCLTIVHVAFA---------VVYFYLTWY---------HKYWDKRGVVTAEP--LTILG 45

309a1ps GLLLGAVHVAFA---------AVYLYLTWH---------HKYWQKRGVLTAEP--LTILG 45

309a2m SLALILLHLLVL---------PIYLYLTWH---------HKYWRKRGLVTARP--LTLLG 45

309a2ps TLGLIVVHLLLL---------PLYVYLTWH---------HRFWRKRGLVTARP--LTMLG 45

308a1m -MLPLVLFILLA---------ATLLFWKWQ---------GNHWRRLGLEAPFG--WPLVG 39

308a1ps LLLLLLLLFFLG---------TLWRRLAWS---------NSHWRRRVVSGPQG--CPLVG 45

4aa1m ELCSILILLVISLS------IYTFYATLNT---------YLRSVLLSLRLTGPPSLPFLG 62

4aa1ps ELCSILALLVISLS------IYLFYAHLDT---------YLRSVILSLRLSGPPTLPILG 73

4C3m PITVFLLGSILIFL------VVYNKRRSR-------------LVKYIEKIPGPAAMPFLG 68

4C3ps PITIFLLASIALFL------VVYNKRRSR-------------LVKHIEKIPGPAAMPFLG 68

4d1m VIGAILASALFVGL------LLYHLKFKR-------------LIDLISYMPGPPVLPLVG 44

4D1ps LLGALLASGLFVAL------LVYQLKFKR-------------VIEVISYMPGPPVLPLVG 44

4d1malt LLSLVLLLAIIALE------MRRFLRNMR-------------------TIPGPLPLPLLG 38

4D1psalt SLVFGAVGTVLVLG------LFSWLPFCRR---------RRRISELAELLPGPKPWPLLG 48

4s3m ALVAFVLWAAFLRY------LPKILNFLR-------------LQRFAKTLPGPTIGELIA 45

4s3ps ALMAFALWALFLRY------LPQILTFLR-------------LQRFAKTLPGPSVSELIA 45

312a1m LGFGLLLLALSLYL------LYVFERQSR-------------IDRLTHKWPAPPALPFIG 44

312a1ps LGLCLLLIVLSLYL------LYAFERQTR-------------IDRLTHNWPAPPSLPILG 45

4g1m MLTTLVGTLVAMAL------YEYWRRNSR-------------EYRMVANIPSPPELPILG 67

4G1ps MLTTLVGTIVALGL------YEYWRRNTR-------------EYRMVANIPSPPGLPLLG 65

4g15m VFYFLLLPTLVLWY------IYWRLSRAH-------------LYRLAGRLPGPRGLPIVG 56

4G15ps VFYFLLLPTLVLWY------IYWRLSRAH-------------LYRLAGRLPGPRGLPIVG 56

4d2m VLLLVAFATLLLWD------FLWRRRGN-------------------GILPGPRPLPFLG 41

4D2ps VVFLVALTTVLVWD------YFWRKRRND--------------IL--HYMPGPRGLPLVG 42

4d14m ELFAILLATALAWD------YMRKRRHNK--------------MYAEAGIRGPKSYPLVG 43

4d14ps ELLVLLLTVALVWD------YLVGRKHKR--------------LFDRAGITGPKAWPLVG 43

4d8m LFLLVVLLFGAGWI------IHLGQADRR--------------RK-VANLPGPICPPLIG 41

4d8ps LLVLVLLLVAVGWL------VHRGQAERR--------------RA-VSNLPGPMCPPLLG 41

4ae1m LLVALLVTRLVASL------FRLALKELR--------------HPLQGVVPSVSRVPLLG 44

4AE1ps LLLTMALTLIVAWL------LQLALREMR--------------HPLRGFVPSVSRVPLVG 44

4d20m TLITGALILLLTWD------FGRKRQRVL--------------AFEKSAIPGPISIPILG 43

4D20ps TLAFGALAVLLTWD------FVRKRQRAA--------------TLERSKISGPLSLPVLG 44

4d21m LLGIAVLIMTLVWD------NSRKQWRVN--------------TFEKSRILGPFTIPIVG 43

4e2m YIFLALPLLLVAYL------ELS--TFRR--------------RRVLNKFNGPRGLPLMG 43

4e2ps YLFLALPLLLVAYL------ELS--TFRR--------------RRALNKFKGPSRLPIVG 43

4e1m CAFLALPLFLVTYF------ELG--LLRR--------------KRMLNKFQGPSMLPLVG 43

4e1ps YLVLALPLLWLAYL------ELK--SLRR--------------RRVLNKFKGPKVLPVVG 43

4e3m LALLVLPLITLVYF------ERK--ASQR--------------RQLLKEFNGPTPVPILG 43

4e3ps LALLALPLLVLVYF------ELR--ASRR--------------RRMLKVFNGPAPVPVLG 43

4ad1m IAIILATILVFKGV------RIFNYIDHM--------------AGIMEMIPGPTPYPFVG 45

4AD1ps IAIILATILVFKGV------KIFNYIDHM--------------AGIMEMIPGPTPYPFVG 45

4p1m ALLYWLHRANKDYH------ILSFFTKRIR---------LKDGTPVEIIAPIAKGKTIFG 56

4p3m VLIQWIYRLNRDYC------ILGFFAKRIR---------TKNGQNPESIAPLVKGSTIFA 56

4p1ps ALVLWLYRINKDYY------ILAFFSRRVR---------TKDGRPVESILPSPKGRTIFA 56

4P2ps VIVHWLYRVNKDYY------IMAFFSRRVR---------TKDGRPVESIVPMIKGRTVFA 58

4P3ps VVIHWLYQVNKDYY------ILAFFSRRVY---------TRDDRPVESLVPSPKGRTIFA 56

4p2m VVIHWIYKVNKDYN------ILAFFARRVQ---------TKDGKPLDSLVPMIKGRTVFA 58

4ac1m AVLTLLLKHINKTY------FILSLTKRVR---------TEDGSPLESKVAIMPGKTRFG 57

4AC1ps LGVWLLLQRLNRTY------FILSLTRRVR---------TEDGSPLESKVAVMPGTTRFG 57

4ac2ps LLCCVLLRRLNRKY------FVLSLCKRLQ---------AEDGSPLESKIAVMPGRTRFG 57

4ac2m FIFRKLWAHLNRTY------FILSLCKRIR---------TEDGSLLESKIYVAPSKTRFG 58

4ac3m GALWLLLRQLNKTY------FILSLCKRVR---------TADGSPLESKVFVVPGKTRFG 57

311a1m ALWPLLLITLTIWI------LVRKWTLLR----------------LGSSLPGPWAFPLLG 39

311a1ps ------------------------------------------------------------

316a1m TATFICFCLASAFN------YFRARRQRS----------------LIKNLKGPFTWPLMG 41

316A1ps TTTFLCFCVASAIN------YFRTRRQRS----------------LIKNLGGPFSWPLMG 41

313a2m VIQLLIAASLILWI------RFLWSRRKLY---------MLMMQLP-----GRMGLPLLG 42

313a3m TFQLLLAVGVCFWI------YFLWSRRRLY---------MMHFKIP-----GPMGLPILG 42

313a1m TINLLLAVGALFWI------YFLWSRRRLY---------FLMLKIP-----GPIGLPILG 42

313C1ps SLHLWIAVGILAWI------YFLWSRRRFY---------LLMLRVK-----GPVGYPFLG 42

313C2ps TLQLWIAVGILAWI------YFLWSRRRFY---------LLMLRVK-----GPVGYPFLG 42

313a5m TLQIFEAFAIILCV------YFLWSRRRFY---------IMMLKLP-----GPMGFPFIG 42

313a4m TWTLWCGLLFLLWI------YFLWSRRRFY---------LLTLKIP-----GPLGYPILG 42

313a4ps TWTLWCGLLFVLWI------YFLWSRRRFY---------LLTLKIP-----GPIGYPLLG 42

313A4bps TWSLWCGLLFVLWI------YFLWSRRRFY---------LLTLKIP-----GPIGYPFLG 42

313b1m ASIILSGWLLLAWL------YFLWSRRRYY---------KVAWQLR-----GPIGWPLIG 42

313b1ps TCIILAIWLLLVWT------YFLWTRRRYY---------KAAWQLK-----GPIGWPLIG 44

318a1m LNIALWACGALLAV------LLAWQQRKCW---------RLIWQLNG--WRGVIQQPVLW 45

318A1ps LYVALWVCGTALAL------LLGWQQRKCW---------RLIWQLNG--WRGVAQQPILW 45

18a1m VFLGLLALVTLLQW-------LVRNYRELR-----------------KLPPGPWGLPVIG 64

18a1ps VFLGFLALVSLLQW-------MLRHYRELR-----------------KLPPGPWGLPVIG 65

306A1m LVPGALVLVILYLC-------ERQCNDLMG-----------------APPPGPWGLPFLG 59

306A1ps VVPGLLILIILWLC-------DHQYDRVLG-----------------RPPPGPWGLPWLG 64

303a1m YTVIWIFCATLLAI-------LFGGVRKPK-----------------RFPPGPAWYPIVG 38

303A1ps YAVIWIFFATLLAV-------LLGGVRKPK-----------------RFPPGPRWYPIVG 38

305a1m IFLCAILIGFVIYS-------LISSARRPK-----------------NFPPGPRFVPWLG 40

305A1ps IFLCAILIGFVIYS-------LIKSVQRPK-----------------NFPPGPRFLPWLG 40

304a1m TLLTICAAVFLCLS-------YRYAVGRPS-----------------GFPPGPPKIPLFG 40

304a1ps LLLTICSAAFLYLS-------YRYAVGRPV-----------------GFPPGPPRIPFFG 40

307a1m IIYGVKRRVLQPVK-------TKNSTEINHN-----------AYQKYTQAPGPRPWPIIG 65

307a1ps ILYKSRRRVCVAIR-------NGKSSTESE--------------QIYEQAPGPRPWPIIG 60

307a2pm LLLKCKQKAFVVIG-------LLYQEKKYQ---------------CFDQAPGPHPWPIIG 61

307a2pps IIFKCNEKATVRIG-------LSNPEKAIR---------------KFGQAPGPQPWPIIG 61

3A 3D 3F 3G

3B 3C 3E 3H 3I 3J

12a4m LSMKMSMPGGK--YKNMELMEMFEAMRQDYG----------DIFFMPGIMGNPPFLSTHN 105

12a5m LFAKSALPGGK--YKNLEMMEMIDALRQDYG----------NIIFLPGMMGRDGLVMTHN 105

12A4ps STVRNFMPGGK--YRKLDIVELFQALQDDYG----------DIFYLPGIMGGPSFLTTHN 104

12A5ps STVRNFMPGGK--YSKLDIVNLFKALQDDYG----------NILYLPGMMGGTSYLMTHN 104

12c1m QLFRGFQKGGE--YHQLGMDDVMRLYKKQFG----------DICLIPGLFGMPSTVFTFN 98

12c1ps QLWRGFQKGGE--FHHLDMAELMDLYRSRFG----------DMVRVPGLFGMPTTVFTFK 108

12e1m QLIRAFLPGGL--YKNLPVHEMFLDMNRQYG----------SIFRMPSVAG-TDLVLTMN 87

12e1ps QMIRAFMPGGR--YKNAPAHEMFLDLSRQFG----------GLFRMPSIAG-TDMVLTMN 89

12d1m KFMRAFMPGGE--FQNASITEYTSAMRKRYG----------DIYVMPGMFGRKDWVTTFN 99

12d1ps QFMRSFMPGGE--FSDASIVEFSMGMRRRYG----------DIFILPGMFGRKDWVVTFN 99

12b2m RMLSFFMPGGA--LRNTNLIQMNRLMREMYG----------DIYCIPGMMGKPNAVFTYN 110

12B2ps RMISYFLPGGK--LHNTNLIQMNRRLRVMYG----------DIYRLPGLMGKPDIVFTYN 113

49A1m NSWRFAPLIGT--YKISDLDKVMNELHVNYG----------KMAKVGGLIGHPDLLFVFD 161

49A1ps NSWRFAPLIGT--YKISELDKVMNELHVNYG----------KMAKVGGLIGHPDLLFVFD 166

301a1m NTWRLMPIIGQ--YTISDVAKISSLLHDRYG----------RIVRFGGLIGRPDLLFIYD 133

301A1ps NTWRLMPIIGQ--YTISDVANISSLLHDRYG----------RIVRFGGLIGRPDLLFIYD 138

302a1m NLYNYLPGIGS--YSWLRLHQAGQDKYEKYG----------AIVRETIVPG-QDIVWLYD 81

302A1ps NLYNYMPIIGS--YSFLRLHQAGQDKYERYG----------AIVRETMAPG-QDIVWLYD 81

314a1m TKWIFLLFFRR--YKMTKLHEVYADLNRQYG----------DIVLEVMPSN-VPIVHLYN 119

314a1ps TKWIFFVFFRR--YKMTKLHEVYADLNRRYG----------DIVLEVMPSN-VPIVHLYK 120

315a1m VVGTLVDLIAA--GGATHLHKYIDARHKQYG----------PIFRER-LGGTQDAVFVSS 113

315a1ps VVGTLLDLIAA--GGATHLHKYIDSRHRQYG----------PIFRER-LGGTQDAVFVSS 107

6a2m NMVGFRKN-----RVMHDFFYDYYNKYRKSGF-----------PFVGFYFLHKPAAFIVD 85

6a2ps NLVGFRKN-----RVIHDIFYDYYNKFRTSGS-----------PFVGFFFLQKPAAFIVD 85

6a8m