Chimpanzee P450s compared with human

 

62 sequences April 5, 2006

 

D. Nelson

 

 

>CYP1A1 NM_000499 human on bottom, chimp XP_510670 on top

          Length = 512

 

 Score =  560 bits (1442), Expect = e-162

 Identities = 274/275 (99%), Positives = 275/275 (100%)

 

Partial seq, one aa diff

The rest of this seq is on chr16_random:21929790-21932380

There is only 1 aa diff in the whole seq

 

Query: 13  MLFPISMSATEFLLASVIFCLVFWVIRASRPRVPKGLKNPPGPWGWPLIGHMLTLGKNPH 72

           MLFPISMSATEFLLASVIFCLVFWVIRASRP+VPKGLKNPPGPWGWPLIGHMLTLGKNPH

Sbjct: 1   MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60

 

Query: 73  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 132

           LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS

Sbjct: 61  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120

 

Query: 133 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 192

           MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG

Sbjct: 121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180

 

Query: 193 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 252

           PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL

Sbjct: 181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240

 

Query: 253 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 287

           RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK

Sbjct: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275

 

 

>CYP1A2 NM_000761 human on bottom, chimp XP_510671  on top

          Length = 515

 

 Score =  959 bits (2480), Expect = 0.0

 Identities = 475/483 (98%), Positives = 481/483 (99%), Gaps = 1/483 (0%)

 

8 amino acid differences, seq gap at end, missing 21 aa

 

Query: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

           MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN

Sbjct: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

 

Query: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

           PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG

Sbjct: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

 

Query: 121 QSMTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180

           QS+TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM

Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180

 

Query: 181 AGPGHFDPYNQVVMSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

           AGPGHFDPYNQVV+SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP

Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

 

Query: 241 ILRYLPNPALQRFKAFNQRFLRFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGG 300

           ILRYLPNPALQRFKAFNQRFL FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS G

Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS-G 299

 

Query: 301 DLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 360

           +LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL

Sbjct: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359

 

Query: 361 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFINQWQVNHDPE 420

           SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF+NQWQVNHDPE

Sbjct: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419

 

Query: 421 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEVFLFLAILLQQL 480

           LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE+FLFLAILLQQL

Sbjct: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479

 

Query: 481 EFS 483

           EFS

Sbjct: 480 EFS 482

 

 

>CYP1B1 NM_000104

human on bottom, chimp XP_515417 on top

 

missing C-term, 2 aa diffs

 Score =  550 bits (1417), Expect = e-159

 Identities = 273/275 (99%), Positives = 274/275 (99%)

 

Query: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLGSAPPGPFAWPLI 60

           MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQL SAPPGPFAWPLI

Sbjct: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

 

Query: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120

           GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F

Sbjct: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

 

Query: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

           ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL

Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

 

Query: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

           LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

 

Query: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

           VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK

Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

 

 

>CYP1B1 NM_000104

human on bottom, chimp XP_515416 on top

 

C-term part, 3 aa diffs

 

 Score =  348 bits (892), Expect = 7e-99

 Identities = 169/172 (98%), Positives = 170/172 (98%)

 

Query: 1   MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 60

           MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP

Sbjct: 372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431

 

Query: 61  VKWPNPENFDPARFLDKDGFINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 120

           VKWPNPENFDPARFLDKDG INKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC

Sbjct: 432 VKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 491

 

Query: 121 NFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAKETCQ 172

           +FRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQAKETCQ

Sbjct: 492 DFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ 543

 

 

>CYP2A7v1 wild type AC008537.3 Exon 8 is different from U22029

          Length = 494

Human on bottom, chimp XP_524272 on top

Only 2 aa diffs in aligned region

 

 Score =  206 bits (523), Expect = 4e-56

 Identities = 105/116 (90%), Positives = 106/116 (91%), Gaps = 9/116 (7%)

 

Query: 36  QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE 95

           QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQ

Sbjct: 218 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ- 276

 

Query: 96  VHPSSQCGEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 151

                   EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE

Sbjct: 277 --------EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

 

 

>CYP2A13   U22028 human on bottom, chimp XP_512681 on top

 

partial seq, one aa diff

 

 Score = 380 (133.8 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

 Identities = 73/73 (100%), Positives = 73/73 (100%)

 

Query:   227 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 286

             GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR

Sbjct:   302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361

 

Query:   287 FGDMLPMGLAHRV 299

             FGDMLPMGLAHRV

Sbjct:   362 FGDMLPMGLAHRV 374

 

 Score = 263 (92.6 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

 Identities = 56/68 (82%), Positives = 57/68 (83%)

 

Query:    22 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQVTGCSPP 81

             ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLG FQFT TSTGQ+      

Sbjct:   166 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQLYEMFSS 225

 

 

>CYP2A18PN = CYP2A7PT U22030 and 2A7PC U22044, human on bottom,

chimp XP_524273 on top

          Length = 275

 

Pseudogene with only one aa diff in aligned region

 Score =  287 bits (734), Expect = 4e-80

 Identities = 188/354 (53%), Positives = 207/354 (58%), Gaps = 81/354 (22%)

 

Query: 1   MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTESVSAMAPC 60

           MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTE +     

Sbjct: 1   MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTEHICDSIMK 60

 

Query: 61  SPFTWGPGGSWCCADMMPSRRLWWTRLRSSAGEVSRPPSTGSSKAVLLFFSVFLLCPLTS 120

               +GP  +                ++ +  + +   S    +A   +          

Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWL---------- 110

 

Query: 121 PSSSSVLGFRG--VTCRTWERTKPLRRFSIATLRDFGVGKRGIKEVSRRRRASSSRPSRA 178

                   F+G  VTCRTWERTKPLRRFSIATLRDFGVGKRGIKE+  +          

Sbjct: 111 --------FKGYGVTCRTWERTKPLRRFSIATLRDFGVGKRGIKEIQEK------AGFLI 156

 

Query: 179 RAVSRTPRVWRREKENTQGEEPARVLSSIDPTFFLSRTTSNVISSIVFGDRFDYEDKSSC 238

           +AV             T+G       SSI PTFFLSRTTSNVISSIVFGDRFDYEDK  

Sbjct: 157 KAV-----------*GTRG-------SSIYPTFFLSRTTSNVISSIVFGDRFDYEDK--- 195

 

Query: 239 KHLNRYPFLFNIFTSPTLIPEHLNKSPQSRPNKSHSHQFLPPDSSPSLPILSLQPQLYEM 298

           K L+    +   F                        QF  P +           +LYEM

Sbjct: 196 KFLSLLCMMLESF------------------------QFTAPSTG----------ELYEM 221

 

Query: 299 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 352

           FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ

Sbjct: 222 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 275

 

 

>CYP2B6 AC023172.1 CDS (hIIB1) cryptic exon 3A = 18813-18856 (hIIB2)

human on bottom, chimp XP_512679 on top

 Score =  471 bits (1211), Expect = e-135

 Identities = 232/245 (94%), Positives = 240/245 (97%)

 

13 differences in a partial sequence, missing about 160 aa

 

Query: 1   MLCGVEAIREALVDKAEAFSGRGKIAIMDPVYQGYGVLFANGNRWKVLRRFSVTIMRDFG 60

           MLCGVEAIREALVDKAEAFSGRGKIA++DP ++GYGV+FANGNRWKVLRRFSVT MRDFG

Sbjct: 77  MLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136

 

Query: 61  MGKRSVEERIQDEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 120

           MGKRSVEERIQ+EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL

Sbjct: 137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196

 

Query: 121 KMLNLFYQTFSLISSISSQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 180

           KMLNLFYQTFSLISS+  QLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL

Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256

 

Query: 181 DPSAPKDLIDTYLLHMEKEKSDAHSEFSHQNLTLNTLSLFFAGTETTSTTLRYGFLLMLK 240

           DPSAPKDLIDTYLLHMEKEKS+AHSEFSHQNL LNTLSLFFAGTETTSTTLRYGFLLMLK

Sbjct: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316

 

Query: 241 YPHVA 245

           YPHVA

Sbjct: 317 YPHVA 321

 

 

>CYP2C8 M17397 human on bottom, chimp XP_508183 on top

          Length = 490

 

12 aa diffs

 

Score =  111 bits (278), Expect = 4e-27

 Identities = 53/56 (94%), Positives = 54/56 (96%)

 

Query: 1  MEPFVVLVLCLSFMLLFSLWRQSSGRRKLPPGPTPLPIIGNMLQIDVKDICKSFSN 56

          MEPFVVLVLCLSFMLLFSLWRQS  RRKLPPGPTPLPIIGNMLQIDVKDICKSF+N

Sbjct: 1  MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTN 56

 

 Score =  858 bits (2217), Expect = 0.0

 Identities = 422/442 (95%), Positives = 426/442 (96%), Gaps = 8/442 (1%)

 

Query: 120 FSKVYGPVFTVYFGMNPIVVLHGYEAVKEALIDNGEEFSGRGSSPISQRITKGLGIISSN 179

           FSKVYGPVFTVYFGMNPIVV HGYEAVKEALIDNGEEFSGRG+SPISQRITKGLGIISSN

Sbjct: 57  FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116

 

Query: 180 GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 239

           GKRWKEIRRFSLT LRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN

Sbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176

 

Query: 240 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLTN 299

           VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVL N

Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236

 

Query: 300 VALTQSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 359

           VALT+SYIREKVKEHQASLDVNNPRDF+DCFLIKMEQEKDNQKSEFNIENLVGTVADLFV

Sbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296

 

Query: 360 AGTETTSTTLRYGLLLLLMHPEVTAKVQEEIDHVIGRHRTPCMQDRSHMPYTDAVVHEIQ 419

           AGTETTSTTLRYGLLLLL HPEVTAKVQEEIDHVIGRHR+PCMQDRSHMPYTDAVVHEIQ

Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356

 

Query: 420 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMTLLTSVLHDDKEFPNPNIFDPGHFLDKN 479

           RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIM LLTSVLHDDKEFPNPNIFDPGHFLDKN

Sbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416

 

Query: 480 GNFKKSDYFMPFSAGNRNSFPFENEFAAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 539

           GNFKKSDYFMPFSAG R          AGEGLARMELFLFLTTILQNFNLKSVDDLKNLN

Sbjct: 417 GNFKKSDYFMPFSAGKR--------ICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 468

 

Query: 540 TTAVTKGIVSLPPSYQICFIPV 561

           TTAVTKGIVSLPPSYQICFIPV

Sbjct: 469 TTAVTKGIVSLPPSYQICFIPV 490

 

 

>CYP2C9 M61857 human on bottom, chimp XP_507939 on top

          Length = 490

 

 Score =  947 bits (2447), Expect = 0.0

 Identities = 472/490 (96%), Positives = 476/490 (97%), Gaps = 8/490 (1%)

 

Small disagreement on assembly, otherwise only 3 aa diffs

 

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNVSML 60

           MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTN+S +

Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

 

Query: 61  ------LQWLAK--VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 112

                 L +  K  VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW

Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

 

Query: 113 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 172

           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

 

Query: 173 IIFHKRFDYKDQQFLNLMEKLNENVKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 232

           IIFHKRFDYKDQQFLNLMEKLNEN+KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM

Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

 

Query: 233 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 292

           KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE

Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

 

Query: 293 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 352

           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID

Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

 

Query: 353 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 412

           LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK

Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

 

Query: 413 KSNYFMPFSAGKRICVGEALARMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 472

           KS YFMPFSAGKRICVGEALA MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP

Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

 

Query: 473 PFYQLCFIPV 482

           PFYQLCFIPV

Sbjct: 481 PFYQLCFIPV 490

 

 

>CYP2C19 M61854 human on bottom, chimp XP_507938 on top

 

Missing N-term, only 4 aa diffs

 Score =  774 bits (1998), Expect = 0.0

 Identities = 392/425 (92%), Positives = 393/425 (92%), Gaps = 26/425 (6%)

 

Query: 1   MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 60

           MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN

Sbjct: 74  MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133

 

Query: 61  FGMGKRSIEDRVQEEARCLVEELR------------------NVICSIIFQKRFDYKDQQ 102

           FGMGKRSIEDRVQEEARCLVEELR                  NVICSIIFQKRFDYKDQQ

Sbjct: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193

 

Query: 103 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMERDILEKVKEHQE 162

           FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME DILEKVKEHQE

Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253

 

Query: 163 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 222

           SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL

Sbjct: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313

 

Query: 223 LKHPEVTVLTRVLSAKVQEEIERVIGRKPEPCCMQDRGHMPYTDAVVHEVQRYIDLLPTS 282

           LKHPEVT       AKVQEEIERVIGR   PC MQDRGHMPYTDAVVHEVQRYIDL+PTS

Sbjct: 314 LKHPEVT-------AKVQEEIERVIGRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTS 365

 

Query: 283 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDKKEFPNPEMFDPRHFLDEGGNFKKSNYF 342

           LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD KEFPNPEMFDPRHFLDEGGNFKKSNYF

Sbjct: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425

 

Query: 343 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGLASVPPFYQL 402

           MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG ASVPPFYQL

Sbjct: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485

 

Query: 403 CFIPV 407

           CFIPV

Sbjct: 486 CFIPV 490

 

 

>CYP2D6 NM_000106 human on bottom, chimp Q2XNC8, ABB77911 on top

swissprot entry, best annotation

 

8 aa diffs

 Score =  995 bits (2572), Expect = 0.0

 Identities = 489/497 (98%), Positives = 494/497 (99%)

 

Query: 1   MGLEALVPLAVIVTIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

           MGLEALVPLAVIV IFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ

Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

 

Query: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

           LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF

Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

 

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

           LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK

Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

 

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAIPVLLHIPALAGKV 240

           AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNA+PVLLHIPALAGKV

Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240

 

Query: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

           LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA

Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

 

Query: 301 DLFSAGIVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVI 360

           DLFSAG+VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA MPYTTAVI

Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360

 

Query: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVWEKPFRFHPEHF 420

           HEVQRFGDIVPLG+THMTSRDIEVQGFRIPKGTTL TNLSSVLKD+AVWEKPFRFHPEHF

Sbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420

 

Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

           LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV

Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

 

Query: 481 FAFLVTPSPYELCAVPR 497

           FAFLV+PSPYELCAVPR

Sbjct: 481 FAFLVSPSPYELCAVPR 497

 

>CYP2D8P1 = CYP2D8P AL021878 comp(55779-60892)

human on bottom, chimp XP_520854 (2D42) on top

 

9 aa diffs

 

 Score =  213 bits (543), Expect = 1e-58

 Identities = 110/119 (92%), Positives = 111/119 (93%)

 

Query: 1   MLNVVPLLLRIPGLAGKVLCSQKAFLTQLDELLTEHRMIWDPAQPPGDLTEAFLAEMEKA 60

           MLNVVPLLLRIPGLAGKVL SQKAFLTQLDELLTEHRMIWDPA PP DLTEAFLAE EKA

Sbjct: 222 MLNVVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMIWDPA*PPRDLTEAFLAEKEKA 281

 

Query: 61  KGNPESSFNDENLCMVVADLFLAGMVTTSVTLAWGLLLMILHPDVQRRVQQIDNVIGQV 119

           KGNPESSFNDENL MVVADLF AGMVTTS+TLAWGLLLMIL PDVQ RVQQIDNVIGQV

Sbjct: 282 KGNPESSFNDENLRMVVADLFFAGMVTTSITLAWGLLLMILRPDVQARVQQIDNVIGQV 340

 

>CYP2E1 J02843 human bottom chimp XP_508139 top

          Length = 493

 

 Score =  658 bits (1698), Expect = 0.0

 Identities = 318/322 (98%), Positives = 321/322 (99%)

 

7 amino acid differences plus a gap of 25 amino acids

 

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

           MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL

Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

 

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

           AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP

Sbjct: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

 

Query: 121 TWKDIRRFSLTTLRNYGMGKEGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

           TWKDIRRFSLTTLRNYGMGK+GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI

Sbjct: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

 

Query: 181 ADILFRKHFDYDDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSVLHYLPGSHRKVIKNVA 240

           ADILFRKHFDY+DEKFLRLMYLFNENFHLLSTPWLQLYNNFPS LHYLPGSHRKVIKNVA

Sbjct: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240

 

Query: 241 EIKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

           E+KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG

Sbjct: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

 

Query: 301 TETTSTTLRYGLLILMKYPEIE 322

           TETTSTTLRYGLLILMKYPEIE

Sbjct: 301 TETTSTTLRYGLLILMKYPEIE 322

 

Sequence gap

 

Query: 741 PYMDAVVHDVQRFITLVPSNLPLEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 800

           PYMDAVVH++QRFITLVPSNLP EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE

Sbjct: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407

 

Query: 801 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 860

           KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK

Sbjct: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467

 

Query: 861 DIDLSPIHIGFGCIPPRYKLCVIPRS 886

           DIDLSPIHIGFGCIPPRYKLCVIPRS

Sbjct: 468 DIDLSPIHIGFGCIPPRYKLCVIPRS 493

 

 

>2F1P AC008537.3 93% identical to 2F1

human on bottom, chimp XP_512682 on top

 

4 aa diffs

 Score =  327 bits (838), Expect = 2e-92

 Identities = 157/168 (93%), Positives = 159/168 (94%)

 

Query: 96  GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYNIFP 155

           GEPFDPTFVLSRS SNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELY+IFP

Sbjct: 1   GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFP 60

 

Query: 156 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIDCFLTKMAEKKEDPLS 215

           SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI CFLTKMAEKKEDPLS

Sbjct: 61  SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI