Chimpanzee P450s compared with human

 

62 sequences April 5, 2006

 

D. Nelson

 

 

>CYP1A1 NM_000499 human on bottom, chimp XP_510670 on top

          Length = 512

 

 Score =  560 bits (1442), Expect = e-162

 Identities = 274/275 (99%), Positives = 275/275 (100%)

 

Partial seq, one aa diff

The rest of this seq is on chr16_random:21929790-21932380

There is only 1 aa diff in the whole seq

 

Query: 13  MLFPISMSATEFLLASVIFCLVFWVIRASRPRVPKGLKNPPGPWGWPLIGHMLTLGKNPH 72

           MLFPISMSATEFLLASVIFCLVFWVIRASRP+VPKGLKNPPGPWGWPLIGHMLTLGKNPH

Sbjct: 1   MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60

 

Query: 73  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 132

           LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS

Sbjct: 61  LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120

 

Query: 133 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 192

           MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG

Sbjct: 121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180

 

Query: 193 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 252

           PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL

Sbjct: 181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240

 

Query: 253 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 287

           RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK

Sbjct: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275

 

 

>CYP1A2 NM_000761 human on bottom, chimp XP_510671  on top

          Length = 515

 

 Score =  959 bits (2480), Expect = 0.0

 Identities = 475/483 (98%), Positives = 481/483 (99%), Gaps = 1/483 (0%)

 

8 amino acid differences, seq gap at end, missing 21 aa

 

Query: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

           MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN

Sbjct: 1   MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

 

Query: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

           PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG

Sbjct: 61  PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

 

Query: 121 QSMTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180

           QS+TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM

Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180

 

Query: 181 AGPGHFDPYNQVVMSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

           AGPGHFDPYNQVV+SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP

Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

 

Query: 241 ILRYLPNPALQRFKAFNQRFLRFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGG 300

           ILRYLPNPALQRFKAFNQRFL FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS G

Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS-G 299

 

Query: 301 DLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 360

           +LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL

Sbjct: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359

 

Query: 361 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFINQWQVNHDPE 420

           SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF+NQWQVNHDPE

Sbjct: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419

 

Query: 421 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEVFLFLAILLQQL 480

           LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE+FLFLAILLQQL

Sbjct: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479

 

Query: 481 EFS 483

           EFS

Sbjct: 480 EFS 482

 

 

>CYP1B1 NM_000104

human on bottom, chimp XP_515417 on top

 

missing C-term, 2 aa diffs

 Score =  550 bits (1417), Expect = e-159

 Identities = 273/275 (99%), Positives = 274/275 (99%)

 

Query: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLGSAPPGPFAWPLI 60

           MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQL SAPPGPFAWPLI

Sbjct: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

 

Query: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120

           GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F

Sbjct: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

 

Query: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

           ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL

Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

 

Query: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

           LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

 

Query: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

           VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK

Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

 

 

>CYP1B1 NM_000104

human on bottom, chimp XP_515416 on top

 

C-term part, 3 aa diffs

 

 Score =  348 bits (892), Expect = 7e-99

 Identities = 169/172 (98%), Positives = 170/172 (98%)

 

Query: 1   MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 60

           MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP

Sbjct: 372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431

 

Query: 61  VKWPNPENFDPARFLDKDGFINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 120

           VKWPNPENFDPARFLDKDG INKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC

Sbjct: 432 VKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 491

 

Query: 121 NFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAKETCQ 172

           +FRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQAKETCQ

Sbjct: 492 DFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ 543

 

 

>CYP2A7v1 wild type AC008537.3 Exon 8 is different from U22029

          Length = 494

Human on bottom, chimp XP_524272 on top

Only 2 aa diffs in aligned region

 

 Score =  206 bits (523), Expect = 4e-56

 Identities = 105/116 (90%), Positives = 106/116 (91%), Gaps = 9/116 (7%)

 

Query: 36  QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE 95

           QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQ

Sbjct: 218 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ- 276

 

Query: 96  VHPSSQCGEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 151

                   EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE

Sbjct: 277 --------EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

 

 

>CYP2A13   U22028 human on bottom, chimp XP_512681 on top

 

partial seq, one aa diff

 

 Score = 380 (133.8 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

 Identities = 73/73 (100%), Positives = 73/73 (100%)

 

Query:   227 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 286

             GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR

Sbjct:   302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361

 

Query:   287 FGDMLPMGLAHRV 299

             FGDMLPMGLAHRV

Sbjct:   362 FGDMLPMGLAHRV 374

 

 Score = 263 (92.6 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

 Identities = 56/68 (82%), Positives = 57/68 (83%)

 

Query:    22 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQVTGCSPP 81

             ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLG FQFT TSTGQ+      

Sbjct:   166 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQLYEMFSS 225

 

 

>CYP2A18PN = CYP2A7PT U22030 and 2A7PC U22044, human on bottom,

chimp XP_524273 on top

          Length = 275

 

Pseudogene with only one aa diff in aligned region

 Score =  287 bits (734), Expect = 4e-80

 Identities = 188/354 (53%), Positives = 207/354 (58%), Gaps = 81/354 (22%)

 

Query: 1   MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTESVSAMAPC 60

           MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTE +     

Sbjct: 1   MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTEHICDSIMK 60

 

Query: 61  SPFTWGPGGSWCCADMMPSRRLWWTRLRSSAGEVSRPPSTGSSKAVLLFFSVFLLCPLTS 120

               +GP  +                ++ +  + +   S    +A   +          

Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWL---------- 110

 

Query: 121 PSSSSVLGFRG--VTCRTWERTKPLRRFSIATLRDFGVGKRGIKEVSRRRRASSSRPSRA 178

                   F+G  VTCRTWERTKPLRRFSIATLRDFGVGKRGIKE+  +          

Sbjct: 111 --------FKGYGVTCRTWERTKPLRRFSIATLRDFGVGKRGIKEIQEK------AGFLI 156

 

Query: 179 RAVSRTPRVWRREKENTQGEEPARVLSSIDPTFFLSRTTSNVISSIVFGDRFDYEDKSSC 238

           +AV             T+G       SSI PTFFLSRTTSNVISSIVFGDRFDYEDK  

Sbjct: 157 KAV-----------*GTRG-------SSIYPTFFLSRTTSNVISSIVFGDRFDYEDK--- 195

 

Query: 239 KHLNRYPFLFNIFTSPTLIPEHLNKSPQSRPNKSHSHQFLPPDSSPSLPILSLQPQLYEM 298

           K L+    +   F                        QF  P +           +LYEM

Sbjct: 196 KFLSLLCMMLESF------------------------QFTAPSTG----------ELYEM 221

 

Query: 299 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 352

           FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ

Sbjct: 222 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 275

 

 

>CYP2B6 AC023172.1 CDS (hIIB1) cryptic exon 3A = 18813-18856 (hIIB2)

human on bottom, chimp XP_512679 on top

 Score =  471 bits (1211), Expect = e-135

 Identities = 232/245 (94%), Positives = 240/245 (97%)

 

13 differences in a partial sequence, missing about 160 aa

 

Query: 1   MLCGVEAIREALVDKAEAFSGRGKIAIMDPVYQGYGVLFANGNRWKVLRRFSVTIMRDFG 60

           MLCGVEAIREALVDKAEAFSGRGKIA++DP ++GYGV+FANGNRWKVLRRFSVT MRDFG

Sbjct: 77  MLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136

 

Query: 61  MGKRSVEERIQDEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 120

           MGKRSVEERIQ+EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL

Sbjct: 137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196

 

Query: 121 KMLNLFYQTFSLISSISSQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 180

           KMLNLFYQTFSLISS+  QLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL

Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256

 

Query: 181 DPSAPKDLIDTYLLHMEKEKSDAHSEFSHQNLTLNTLSLFFAGTETTSTTLRYGFLLMLK 240

           DPSAPKDLIDTYLLHMEKEKS+AHSEFSHQNL LNTLSLFFAGTETTSTTLRYGFLLMLK

Sbjct: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316

 

Query: 241 YPHVA 245

           YPHVA

Sbjct: 317 YPHVA 321

 

 

>CYP2C8 M17397 human on bottom, chimp XP_508183 on top

          Length = 490

 

12 aa diffs

 

Score =  111 bits (278), Expect = 4e-27

 Identities = 53/56 (94%), Positives = 54/56 (96%)

 

Query: 1  MEPFVVLVLCLSFMLLFSLWRQSSGRRKLPPGPTPLPIIGNMLQIDVKDICKSFSN 56

          MEPFVVLVLCLSFMLLFSLWRQS  RRKLPPGPTPLPIIGNMLQIDVKDICKSF+N

Sbjct: 1  MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTN 56

 

 Score =  858 bits (2217), Expect = 0.0

 Identities = 422/442 (95%), Positives = 426/442 (96%), Gaps = 8/442 (1%)

 

Query: 120 FSKVYGPVFTVYFGMNPIVVLHGYEAVKEALIDNGEEFSGRGSSPISQRITKGLGIISSN 179

           FSKVYGPVFTVYFGMNPIVV HGYEAVKEALIDNGEEFSGRG+SPISQRITKGLGIISSN

Sbjct: 57  FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116

 

Query: 180 GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 239

           GKRWKEIRRFSLT LRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN

Sbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176

 

Query: 240 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLTN 299

           VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVL N

Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236

 

Query: 300 VALTQSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 359

           VALT+SYIREKVKEHQASLDVNNPRDF+DCFLIKMEQEKDNQKSEFNIENLVGTVADLFV

Sbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296

 

Query: 360 AGTETTSTTLRYGLLLLLMHPEVTAKVQEEIDHVIGRHRTPCMQDRSHMPYTDAVVHEIQ 419

           AGTETTSTTLRYGLLLLL HPEVTAKVQEEIDHVIGRHR+PCMQDRSHMPYTDAVVHEIQ

Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356

 

Query: 420 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMTLLTSVLHDDKEFPNPNIFDPGHFLDKN 479

           RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIM LLTSVLHDDKEFPNPNIFDPGHFLDKN

Sbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416

 

Query: 480 GNFKKSDYFMPFSAGNRNSFPFENEFAAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 539

           GNFKKSDYFMPFSAG R          AGEGLARMELFLFLTTILQNFNLKSVDDLKNLN

Sbjct: 417 GNFKKSDYFMPFSAGKR--------ICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 468

 

Query: 540 TTAVTKGIVSLPPSYQICFIPV 561

           TTAVTKGIVSLPPSYQICFIPV

Sbjct: 469 TTAVTKGIVSLPPSYQICFIPV 490

 

 

>CYP2C9 M61857 human on bottom, chimp XP_507939 on top

          Length = 490

 

 Score =  947 bits (2447), Expect = 0.0

 Identities = 472/490 (96%), Positives = 476/490 (97%), Gaps = 8/490 (1%)

 

Small disagreement on assembly, otherwise only 3 aa diffs

 

Query: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNVSML 60

           MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTN+S +

Sbjct: 1   MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

 

Query: 61  ------LQWLAK--VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 112

                 L +  K  VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW

Sbjct: 61  YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

 

Query: 113 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 172

           KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

 

Query: 173 IIFHKRFDYKDQQFLNLMEKLNENVKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 232

           IIFHKRFDYKDQQFLNLMEKLNEN+KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM

Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

 

Query: 233 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 292

           KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE

Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

 

Query: 293 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 352

           TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID

Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

 

Query: 353 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 412

           LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK

Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

 

Query: 413 KSNYFMPFSAGKRICVGEALARMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 472

           KS YFMPFSAGKRICVGEALA MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP

Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

 

Query: 473 PFYQLCFIPV 482

           PFYQLCFIPV

Sbjct: 481 PFYQLCFIPV 490

 

 

>CYP2C19 M61854 human on bottom, chimp XP_507938 on top

 

Missing N-term, only 4 aa diffs

 Score =  774 bits (1998), Expect = 0.0

 Identities = 392/425 (92%), Positives = 393/425 (92%), Gaps = 26/425 (6%)

 

Query: 1   MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 60

           MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN

Sbjct: 74  MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133

 

Query: 61  FGMGKRSIEDRVQEEARCLVEELR------------------NVICSIIFQKRFDYKDQQ 102

           FGMGKRSIEDRVQEEARCLVEELR                  NVICSIIFQKRFDYKDQQ

Sbjct: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193

 

Query: 103 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMERDILEKVKEHQE 162

           FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME DILEKVKEHQE

Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253

 

Query: 163 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 222

           SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL

Sbjct: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313

 

Query: 223 LKHPEVTVLTRVLSAKVQEEIERVIGRKPEPCCMQDRGHMPYTDAVVHEVQRYIDLLPTS 282

           LKHPEVT       AKVQEEIERVIGR   PC MQDRGHMPYTDAVVHEVQRYIDL+PTS

Sbjct: 314 LKHPEVT-------AKVQEEIERVIGRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTS 365

 

Query: 283 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDKKEFPNPEMFDPRHFLDEGGNFKKSNYF 342

           LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD KEFPNPEMFDPRHFLDEGGNFKKSNYF

Sbjct: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425

 

Query: 343 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGLASVPPFYQL 402

           MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG ASVPPFYQL

Sbjct: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485

 

Query: 403 CFIPV 407

           CFIPV

Sbjct: 486 CFIPV 490

 

 

>CYP2D6 NM_000106 human on bottom, chimp Q2XNC8, ABB77911 on top

swissprot entry, best annotation

 

8 aa diffs

 Score =  995 bits (2572), Expect = 0.0

 Identities = 489/497 (98%), Positives = 494/497 (99%)

 

Query: 1   MGLEALVPLAVIVTIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

           MGLEALVPLAVIV IFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ

Sbjct: 1   MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

 

Query: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

           LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF

Sbjct: 61  LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

 

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

           LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK

Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

 

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAIPVLLHIPALAGKV 240

           AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNA+PVLLHIPALAGKV

Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240

 

Query: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

           LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA

Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

 

Query: 301 DLFSAGIVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVI 360

           DLFSAG+VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA MPYTTAVI

Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360

 

Query: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVWEKPFRFHPEHF 420

           HEVQRFGDIVPLG+THMTSRDIEVQGFRIPKGTTL TNLSSVLKD+AVWEKPFRFHPEHF

Sbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420

 

Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

           LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV

Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

 

Query: 481 FAFLVTPSPYELCAVPR 497

           FAFLV+PSPYELCAVPR

Sbjct: 481 FAFLVSPSPYELCAVPR 497

 

>CYP2D8P1 = CYP2D8P AL021878 comp(55779-60892)

human on bottom, chimp XP_520854 (2D42) on top

 

9 aa diffs

 

 Score =  213 bits (543), Expect = 1e-58

 Identities = 110/119 (92%), Positives = 111/119 (93%)

 

Query: 1   MLNVVPLLLRIPGLAGKVLCSQKAFLTQLDELLTEHRMIWDPAQPPGDLTEAFLAEMEKA 60

           MLNVVPLLLRIPGLAGKVL SQKAFLTQLDELLTEHRMIWDPA PP DLTEAFLAE EKA

Sbjct: 222 MLNVVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMIWDPA*PPRDLTEAFLAEKEKA 281

 

Query: 61  KGNPESSFNDENLCMVVADLFLAGMVTTSVTLAWGLLLMILHPDVQRRVQQIDNVIGQV 119

           KGNPESSFNDENL MVVADLF AGMVTTS+TLAWGLLLMIL PDVQ RVQQIDNVIGQV

Sbjct: 282 KGNPESSFNDENLRMVVADLFFAGMVTTSITLAWGLLLMILRPDVQARVQQIDNVIGQV 340

 

>CYP2E1 J02843 human bottom chimp XP_508139 top

          Length = 493

 

 Score =  658 bits (1698), Expect = 0.0

 Identities = 318/322 (98%), Positives = 321/322 (99%)

 

7 amino acid differences plus a gap of 25 amino acids

 

Query: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

           MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL

Sbjct: 1   MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

 

Query: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

           AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP

Sbjct: 61  AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

 

Query: 121 TWKDIRRFSLTTLRNYGMGKEGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

           TWKDIRRFSLTTLRNYGMGK+GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI

Sbjct: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

 

Query: 181 ADILFRKHFDYDDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSVLHYLPGSHRKVIKNVA 240

           ADILFRKHFDY+DEKFLRLMYLFNENFHLLSTPWLQLYNNFPS LHYLPGSHRKVIKNVA

Sbjct: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240

 

Query: 241 EIKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

           E+KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG

Sbjct: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

 

Query: 301 TETTSTTLRYGLLILMKYPEIE 322

           TETTSTTLRYGLLILMKYPEIE

Sbjct: 301 TETTSTTLRYGLLILMKYPEIE 322

 

Sequence gap

 

Query: 741 PYMDAVVHDVQRFITLVPSNLPLEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 800

           PYMDAVVH++QRFITLVPSNLP EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE

Sbjct: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407

 

Query: 801 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 860

           KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK

Sbjct: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467

 

Query: 861 DIDLSPIHIGFGCIPPRYKLCVIPRS 886

           DIDLSPIHIGFGCIPPRYKLCVIPRS

Sbjct: 468 DIDLSPIHIGFGCIPPRYKLCVIPRS 493

 

 

>2F1P AC008537.3 93% identical to 2F1

human on bottom, chimp XP_512682 on top

 

4 aa diffs

 Score =  327 bits (838), Expect = 2e-92

 Identities = 157/168 (93%), Positives = 159/168 (94%)

 

Query: 96  GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYNIFP 155

           GEPFDPTFVLSRS SNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELY+IFP

Sbjct: 1   GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFP 60

 

Query: 156 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIDCFLTKMAEKKEDPLS 215

           SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI CFLTKMAEKKEDPLS

Sbjct: 61  SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLTKMAEKKEDPLS 120

 

Query: 216 HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQGTLAHTCN 263

           HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLA MKYPKVQ  +    N

Sbjct: 121 HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQAHVQEEIN 168

 

 

>CYP2G2P AC008962 comp(28700-40696) seq of gene has two in frame stop codons

human on bottom, chimp XP_512680 on top

Pseudogene in human.  Is it a pseudogene in chimp?

 

 Score =  493 bits (1268), Expect = e-142

 Identities = 267/344 (77%), Positives = 274/344 (79%), Gaps = 50/344 (14%)

 

Query: 1   MEMGGAVTIFLALCLSCLLILIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

           MEMGGAVTIFLALCLSCLLILIAWK MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK

Sbjct: 1   MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

 

Query: 61  LREKYGTVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIEQNFQGHELNTAR 120

           LREKY  VFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASI+QNFQGH     

Sbjct: 61  LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGH------ 114

 

Query: 121 GGRQKPETEILAGVALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEASYLLEEFRK 180

                       GVALANGERWRIL RF LTILRDFGMGKRSIEERIQEEASYLLEEFRK

Sbjct: 115 ------------GVALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRK 162

 

Query: 181 TKVG-----FLSESWVRPLFG--------------FLLIL-------------FSALYDM 208

           TK       FL    V  +                FL +L             ++ LYDM

Sbjct: 163 TKGAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQLYDM 222

 

Query: 209 YSGIMQHLPGRHNRIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKNKP 268

           YSGIMQ+LPGRHN IYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKN P

Sbjct: 223 YSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKNNP 282

 

Query: 269 YTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEAQ 312

            TEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEA+

Sbjct: 283 RTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEAK 326

 

 

 Score =  160 bits (405), Expect = 9e-42

 Identities = 85/109 (77%), Positives = 88/109 (80%), Gaps = 18/109 (16%)

 

Query: 324 GSRPVVVLCGHEAVKEALIDQADDFSGRGELASIEQNFQGHELNTARGGRQKPETEILAG 383

           G RPVVVLCGHEAVKEAL+DQAD+FSGRGELASI+QNFQGH                  G

Sbjct: 74  GPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGH------------------G 115

 

Query: 384 VALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK 432

           VALANGERWRIL RF LTILRDFGMGKRSIEERIQEEASYLLEEFRKTK

Sbjct: 116 VALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK 164

 

 

 Score =  227 bits (579), Expect = 6e-62

 Identities = 113/128 (88%), Positives = 115/128 (89%), Gaps = 2/128 (1%)

 

Query: 432 KRLVDIVPMGVPHNIIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFCYPDAFYPQHFLDE 491

           +RLVDIVPMGVPHN+IRDTQFRGYLLPKGTDVFPLLGSVLKDPKYF YPDAFYPQHFLDE

Sbjct: 360 QRLVDIVPMGVPHNLIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDE 419

 

Query: 492 QGRFKKNEAFVPFSS--GKRICLGEAMARMELFLYFTSTLQNFSLHSLVPLADIDITPKA 549

           QGRFKKNEAFVPFSS  GKRICLGEAM RMELFLYFTSTLQNFSLHSLVP  DIDITPK

Sbjct: 420 QGRFKKNEAFVPFSSGRGKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKL 479

 

Query: 550 LRLWQHPP 557

                 PP

Sbjct: 480 SGFGNIPP 487

 

 

>CYP2J2 NM_000775 chr 1 human on bottom, chimp XP_513445 on top

          Length = 497

 

Missing the C-helix region, yellow areas are intron boundary diffs

 

 Score =  937 bits (2423), Expect = 0.0

 Identities = 471/501 (94%), Positives = 473/501 (94%), Gaps = 23/501 (4%)

 

7 aa diffs

 

Query: 1   MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60

           MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD

Sbjct: 1   MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60

 

Query: 61  FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPIREHI 120

           FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTP+REHI

Sbjct: 61  FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI 120

 

Query: 121 FK------------------TLTALRNFGLGKKSLEERIQEEAQHLTEAIKKENGQPFDP 162

           FK                  TLTALRNFGLGKKSLEERIQEEAQHLTEAIK+ENGQPFDP

Sbjct: 121 FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP 180

 

Query: 163 HFKINKAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 222

           HFKIN AVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL

Sbjct: 181 HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 240

 

Query: 223 PGPHQTLFSNWKKLKLFVSHMIDKHRKDRNPAETRDFIDAYLKEMS-HTGNPTSSFHEEN 281

           PGPHQTLFSNWKKLKLFVSHMIDKHRKD NPAETRDFIDAYLKEMS HTGNPTSSFHEEN

Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN 300

 

Query: 282 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQGEHVEKVQAEIDRVIGQGQQPSTAAR 341

           LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ    EKVQ EIDRVIGQGQQPSTAAR

Sbjct: 301 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ----EKVQVEIDRVIGQGQQPSTAAR 356

 

Query: 342 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTYLTALHRDPTEWA 401

           ESMPYTNAVIHEVQRMGNIIP NVPREVTVDTTLAGYHLPKGTMILT LTALHRDPTEWA

Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPQNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

 

Query: 402 TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 461

           TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN

Sbjct: 417 TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 476

 

Query: 462 EKLSLKFRMGITISPVSHRLC 482

           EKLSLKFRMGITISPVSHRLC

Sbjct: 477 EKLSLKFRMGITISPVSHRLC 497

 

>CYP2R1 Mikael Oscarson AC090835.6 Homo sapiens chromosome 11

human on bottom, chimp XP_508301 on top

 

N-term only, one aa diff

 

 Score =  154 bits (389), Expect = 2e-40

 Identities = 74/76 (97%), Positives = 75/76 (98%)

 

Query: 40  MWKLWRAEEGAAALGCALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 99

           MWKLWRAEEGAAALG ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE

Sbjct: 1   MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 60

 

Query: 100 LPHVYMRKQSQVYGE 114

           LPHVYMRKQSQVYGE

Sbjct: 61  LPHVYMRKQSQVYGE 75

 

>CYP2R1 Mikael Oscarson AC090835.6 Homo sapiens chromosome 11

human on bottom chimp XP_508300 on top

 

 Score =  335 bits (858), Expect = 5e-95

 Identities = 157/158 (99%), Positives = 157/158 (99%)

 

C-term only, 1 aa diff

 

Query: 1   MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 60

           MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN

Sbjct: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403

 

Query: 61  LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEQLARMEMFLFFT 120

           LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE LARMEMFLFFT

Sbjct: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFT 463

 

Query: 121 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 158

           ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR

Sbjct: 464 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501

 

 

>CYP2S1 AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13

human on bottom, chimp XP_512683 on top

Missing C-term Only 4 aa diffs

 Score =  592 bits (1527), Expect = e-172

 Identities = 296/300 (98%), Positives = 298/300 (99%)

 

Query: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

           MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL

Sbjct: 1   MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

 

Query: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

           SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN

Sbjct: 61  SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

 

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGGPFDPSMLVAQATSN 180

           GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEG PFDPS+L+AQATSN

Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

 

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

           VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH

Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

 

Query: 241 VSTLAAFTVRQVQQHQGNLDALGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

           VSTLAAFTVRQVQQHQGNLDA GPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL

Sbjct: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

 

 

>CYP2T2P AC008537 human on bottom, chimp XP_512678 on top

          Length = 457

 

Only 4 aa diffs in aligned regions

 

 Score =  205 bits (522), Expect = 2e-55

 Identities = 124/216 (57%), Positives = 130/216 (60%), Gaps = 53/216 (24%)

 

Query: 207 GGRNSGFVKLSGRWGRVFTVRLGPRPAVVLCGYAALRDALVLQADAVSGRGSMAVFERFT 266

           GG +     LSGRWGRVFTVRLGPRPAV LCGYAALRDALVLQADAVSGRGSMAVFERFT

Sbjct: 26  GGLDRALHSLSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFT 85

 

Query: 267 RGNS------------------------------EAPALDLPARTLQAGREPRLTPCGYW 296

           RGN                               EA  L+  A  L   +     P   

Sbjct: 86  RGNGILFSNRPCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATIGAPFDPV 145

 

Query: 297 IMLYPMLS----VLVFGNRYGYGDPEFLRLLNLFSDNFRIISSRWGE------------- 339

            +L   +S     LVFGNRY YGDPEFLRLLNLFSDNF IISSRWGE            

Sbjct: 146 RLLDNAVSNVICSLVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRI 205

 

Query: 340 ------LRVISEQIQRHWQMRQPAEPRDFIDCVTRW 369

                 LRVISEQIQRHWQMRQPAEPRDFIDC+TRW

Sbjct: 206 FRNFSELRVISEQIQRHWQMRQPAEPRDFIDCLTRW 241

 

 

>CYP2U1 AC096564.3 missing last exon, last exon from AC000016.1

human on bottom chimp XP_526649 on top

partial assembly, missing C-term/ N-term is too long, retained intron

There is a known GC boundary after SENT so that is why the program

Did not find the C-term.  Only one aa diff

 

 Score =  863 bits (2229), Expect = 0.0

 Identities = 428/447 (95%), Positives = 428/447 (95%), Gaps = 18/447 (4%)

 

Query: 53  MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 112

           MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP

Sbjct: 1   MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 60

 

Query: 113 PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 172

           PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF

Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

 

Query: 173 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGEREVVGCGYADAADES 232

           FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKG               

Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKG---------------- 164

 

Query: 233 PGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHREDPFCPFS 292

             VVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKH EDPFCPFS

Sbjct: 165 --VVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFS 222

 

Query: 293 IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG 352

           IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG

Sbjct: 223 IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG 282

 

Query: 353 PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL 412

           PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL

Sbjct: 283 PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL 342

 

Query: 413 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 472

           FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY

Sbjct: 343 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 402

 

Query: 473 TEATIMEVQRLTVVVPLAIPHMTSENT 499

           TEATIMEVQRLTVVVPLAIPHMTSENT

Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENT 429

 

 

>CYP2W1 AC073957.7 chromosome 7 clone RP11-449P15 40% to 2F1

human on bottom chimp XP_518926 on top

Partial seq, only 3 aa diffs

 

 Score =  645 bits (1663), Expect = 0.0

 Identities = 322/325 (99%), Positives = 323/325 (99%)

 

Query: 1   MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF 60

           MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF

Sbjct: 57  MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF 116

 

Query: 61  SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS 120

           SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS

Sbjct: 117 SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS 176

 

Query: 121 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK 180

           NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK

Sbjct: 177 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK 236

 

Query: 181 IEEVRAILRTLLEARRPHMCVGDPVRSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA 240

           IEEVRAILRTLLEARRPH+C GDPV SYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA

Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA 296

 

Query: 241 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 300

           GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR

Sbjct: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356

 

Query: 301 FITLLPHVPRCTAADTQLGGFLLPK 325

           FITLLPHVPRCTAADTQLGGFLLPK

Sbjct: 357 FITLLPHVPRCTAADTQLGGFLLPK 381

 

 

>CYP2AB1P = old 2D31P chr3q27.1 185030751-185015757 - strand build 33

human on bottom, chimp XP_526403 on top

 

10 aa diffs

 Score =  556 bits (1434), Expect = e-161

 Identities = 310/437 (70%), Positives = 324/437 (74%), Gaps = 70/437 (16%)

 

Query: 17  LHKATT-RLVQSVFTVWVGPIPVAVLSGFQAVKEALVSNSEQFSGRSLTPLFQDLFGERG 75

           LH  T  +L QSVFTVWVGPIPVAVLSGFQ VKEALVSNSEQFSGRSLTPLFQDLFGERG

Sbjct: 50  LHPETLLQLAQSVFTVWVGPIPVAVLSGFQVVKEALVSNSEQFSGRSLTPLFQDLFGERG 109

 

Query: 76  IICSSGHTWRQKRRFCLVMIXGLGLGKLALEVQLQKEAAELAEAFRQEQG----PHQEIF 131

           IICSSGHTWRQKRRFCLVMI GLGLGKLALEVQLQKEAAELAEAFRQEQG    P   I

Sbjct: 110 IICSSGHTWRQKRRFCLVMI*GLGLGKLALEVQLQKEAAELAEAFRQEQGRPFDPQVSIV 169

 

Query: 132 R---------------------YQEVVRSL---------------------IC------Q 143

           R                     +QE+ +++                     +C      Q

Sbjct: 170 RSTVRVIGALVFGHHFLLEDPIFQELTQAIDFGLAFVSTVWRRLYDVFPWALCHLPGPHQ 229

 

Query: 144 EITR---------------HKLRAPEAPMDFISCYLAQISKAMDDPVSTFNQENLVKVVI 188

           EI R               HKLRAPEAP DFISCYLAQISKAMDDPVSTFNQENLV VVI

Sbjct: 230 EIFRYQEVVLSLIHQEITRHKLRAPEAPRDFISCYLAQISKAMDDPVSTFNQENLV*VVI 289

 

Query: 189 DLFLGGTDTTATTLCWALIHMIQHRAVQG--ERPLVTLWLTAQCMGLLDHGHCLHRSPCS 246

           DLFLGGTDTTATTLCWALIHMIQH AVQG  +  L  +   A  +   D     +    

Sbjct: 290 DLFLGGTDTTATTLCWALIHMIQHGAVQGTVQLELDEVLGAAPVVCYEDRKRLPYTXAVL 349

 

Query: 247 VAPGRLSSVVAVGAVRQCVTSTRVCSYPMSKGTIILPNLASVLYDPESWETPRQFNPGHF 306

               RLSSV+A+GAVRQCVTSTRVCSYP+SKGTIILPNLASVLYDPE WETPRQFNPGHF

Sbjct: 350 HDVQRLSSVMAMGAVRQCVTSTRVCSYPVSKGTIILPNLASVLYDPECWETPRQFNPGHF 409

 

Query: 307 SDKDANFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI 366

           SDKD NFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI

Sbjct: 410 SDKDGNFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI 469

 

Query: 367 FGGTWQPQPQEICAVPR 383

           FGGTWQPQPQEICAVPR

Sbjct: 470 FGGTWQPQPQEICAVPR 486

 

 

>CYP3A4 J04449 human on bottom, chimp XP_519243 on top

          Length = 502

 

N-term only, 7aa diffs

 

 Score =  345 bits (886), Expect = 3e-98

 Identities = 167/174 (95%), Positives = 172/174 (98%)

 

Query: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYRKGFCMF 60

           MA+IPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY KGFCMF

Sbjct: 1   MAVIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

 

Query: 61  DMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

           DMECHKKYGKV GFYDG+QPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI

Sbjct: 61  DMECHKKYGKVCGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

 

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREADTGKPVTLKE 174

           AEDEEWKR+RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA+TGKPVTLK+

Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD 174

 

 

>CYP3A5_v1 NM_000777 human on bottom, chimp XP_519240 on top

          Length = 502

 

Missing N-term, probably a hybrid assembly top part does not match

42 differences

 

 Score =  756 bits (1953), Expect = 0.0

 Identities = 377/426 (88%), Positives = 398/426 (93%), Gaps = 4/426 (0%)

 

Query: 19  YDGLQPVLAITDPDMIKTVLVKECYSVFTNRRPLGPVGFMKSAISRAEDEEWKRIRSLLS 78

           Y+G  PVLAITDPD+I+TVLVKECYSVFTNRR LGPVGFMKSAIS AEDEEWKRIRSLLS

Sbjct: 75  YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLS 134

 

Query: 79  PTFTSGKLKEMVPIIAQYGDVLVRNMRREADTGMPVTLKDVFGAYSMDVITSTSFGVNID 138

           PTFTSGKLKEM PIIAQYGDVLVRN+RREA+ G PVTLKD+FGAYSMDVIT TSFGVNID

Sbjct: 135 PTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194

 

Query: 139 SLNNPQDPFVENTKKLLRFNSLDPFILSIKIFPFLTPILEALNITVFPRKVTSFLTKSVK 198

           SLNNPQDPFVE+TKK L+F  LDP  LSI +FPFLTP+ EALN+++FP+   +FL+KSV

Sbjct: 195 SLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVN 254

 

Query: 199 RIKEGRLKETQKHRVDFLQLMIDSQNSKDMESHKGFCKTLSDLELAAQSIIFIFAGYETT 258

           R+K+ RL + QKHR+DFLQLMIDSQNSK+ ESHK     LSDLELAAQSIIFIFAGYETT

Sbjct: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA----LSDLELAAQSIIFIFAGYETT 310

 

Query: 259 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 318

           SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA

Sbjct: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370

 

Query: 319 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 378

           IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI

Sbjct: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430

 

Query: 379 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 438

           YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL

Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490

 

Query: 439 KVDSRD 444

           KVDSRD

Sbjct: 491 KVDSRD 496

 

Top part is more like 3A7 see below

CYP3A7 NM_000765

          Length = 503

 

17 differences, might be a chimp specific CYP3 seq, not in humans

 

 Score =  391 bits (1005), Expect = e-112

 Identities = 197/219 (89%), Positives = 206/219 (94%)

 

Query: 14  KKGSFYDGLQPVLAITDPDMIKTVLVKECYSVFTNRRPLGPVGFMKSAISRAEDEEWKRI 73

           K    YD  QP+LAITDPDMIKTVLVKECYSVFTNRRP GPVGFMK+AIS AEDEEWKRI

Sbjct: 70  KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRI 129

 

Query: 74  RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNMRREADTGMPVTLKDVFGAYSMDVITSTSF 133

           RSLLSPTFTSGKLKEMVPIIAQYGDVLVRN+RREA+TG PVTLK VFGAYSMDVITSTSF

Sbjct: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSF 189

 

Query: 134 GVNIDSLNNPQDPFVENTKKLLRFNSLDPFILSIKIFPFLTPILEALNITVFPRKVTSFL 193

           GV+IDSLNNPQDPFVENTKKLLRFN LDPF+LSIK+FPFLTPILEALNITVFPRKV SFL

Sbjct: 190 GVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFL 249

 

Query: 194 TKSVKRIKEGRLKETQKHRVDFLQLMIDSQNSKDMESHK 232

           TKSVK+IKEGRLKETQKHRVDFLQLMIDSQNSKD E+HK

Sbjct: 250 TKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK 288

 

 

>CYP3A7 NM_000765 human on bottom chimp XP_519242 on top

          Length = 503

 

N-term only 100%

 

 Score =  114 bits (285), Expect = 7e-29

 Identities = 55/55 (100%), Positives = 55/55 (100%)

 

Query: 1  MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK 55

          MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK

Sbjct: 1  MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK 55

 

 

>CYP3A7 NM_000765 human on bottom, chimp XP_519241 on top

          Length = 503

 

Partial seq, only 2 aa diffs

 

Score =  104 bits (260), Expect = 3e-25

 Identities = 49/50 (98%), Positives = 50/50 (100%)

 

Query: 80  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED 129

           IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK+AISIAED

Sbjct: 74  IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED 123

 

 Score =  254 bits (649), Expect = 2e-70

 Identities = 131/142 (92%), Positives = 135/142 (95%)

 

Query: 151 EVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSED 210

           +VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNS+D

Sbjct: 224 KVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKD 283

 

Query: 211 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 270

           SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA

Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343

 

Query: 271 PPTYDTVLQLESTNMELGSVKR 292

           PPTYDTVLQLE  +M +    R

Sbjct: 344 PPTYDTVLQLEYLDMVVNETLR 365

 

 

>CYP3A43 AC011904 human on bottom, chimp XP_527830 on top

          Length = 504

 

 Score =  811 bits (2094), Expect = 0.0

 Identities = 407/425 (95%), Positives = 410/425 (96%), Gaps = 9/425 (2%)

 

4 amino acid differences and a difference at an intron boundary

Missing the C-terminal

 

Query: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

           MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF

Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

 

Query: 61  DRECNEKYGEMWELYEGQQPMLVIMDPDMIKTVLVKECYSVFTNRLPLGPMGFLKSALSF 120

           DRECNEKYGEMW LYEGQQPMLVIMDPDMIKTVLVKECYSVFTN++PLGPMGFLKSALSF

Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

 

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLK-DFFGAY 179

           AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLK DFFGAY

Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKEDFFGAY 180

 

Query: 180 TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI--------FFEALNIG 231

           TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI         FEALNIG

Sbjct: 181 TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIG 240

 

Query: 232 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 291

           LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS

Sbjct: 241 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 300

 

Query: 292 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 351

           IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV

Sbjct: 301 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 360

 

Query: 352 VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 410

           VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER

Sbjct: 361 VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 419

 

 

>CYP4A11 NM_000778 12 exons human on bottom, chimp XP_524697 on top

          Length = 519

 

Assembly defects, only 3 aa diffs

 

Query: 1  MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60

          MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF

Sbjct: 1  MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60

 

Query: 61 GHIQEPYVGLMADSVRVMLDKWEELLGQDSP 91

          GHIQE    L  D     + KW E      P

Sbjct: 61 GHIQE----LQQDQELQRIQKWVETFPSACP 87

 

 

 Score =  562 bits (1449), Expect = e-163

 Identities = 289/365 (79%), Positives = 297/365 (81%), Gaps = 40/365 (10%)

 

Query: 29  LLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEPYVGLMADSVRVMLDKWEELLGQ 88

           LLL+     + HR+ L         P  H+    I +PYVGLMADSVRVMLDKWEELLGQ

Sbjct: 131 LLLLNGQTWFQHRRMLT--------PAFHY---DILKPYVGLMADSVRVMLDKWEELLGQ 179

 

Query: 89  DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 148

           DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN

Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239

 

Query: 149 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK 208

           DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK

Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK 299

 

Query: 209 VSMCRRGLSLCPEVQSKRQALHFHHGLPRWRMGASCQTRTSVLRWTRFMFEGHDTTASGI 268

           +                               G+    +        FMFEGHDTTASGI

Sbjct: 300 MEN-----------------------------GSILSDKDLRAEVDTFMFEGHDTTASGI 330

 

Query: 269 SWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 328

           SWILYALATHPKHQERCREEIH LLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG

Sbjct: 331 SWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 390

 

Query: 329 RELSTPVTFPDGRSLPKGIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF 388

           RELSTPVTFPDGRSLPKGIMV LSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF

Sbjct: 391 RELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF 450

 

Query: 389 SGGSR 393

           SGGSR

Sbjct: 451 SGGSR 455

 

>CYP4A11 NM_000778 12 exons human on bottom, chimp XP_513388 on top

          Length = 519

Continuation of 4A11 or, it might be 4A22, C-term only

 Score =  454 bits (1167), Expect = e-130

 Identities = 217/220 (98%), Positives = 218/220 (99%)

 

Query: 1   MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGA 60

           MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGA

Sbjct: 300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGA 359

 

Query: 61  SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVFLSIYGLH 120

           SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMV LSIYGLH

Sbjct: 360 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLH 419

 

Query: 121 HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE 180

           HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE

Sbjct: 420 HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE 479

 

Query: 181 LLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 220

           LLPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL

Sbjct: 480 LLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519

 

>CYP4B1 NM_000779 human on bottom, chimp XP_513140 on top

          Length = 511

 

Missing N-term only 4 aa diffs

 

 Score =  633 bits (1632), Expect = 0.0

 Identities = 317/363 (87%), Positives = 318/363 (87%), Gaps = 15/363 (4%)

 

Query: 1   MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ 60

           MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ

Sbjct: 164 MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ 223

 

Query: 61  QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVQKKIQNRRHL 120

           QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKV+KKIQNRRHL

Sbjct: 224 QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHL 283

 

Query: 121 DFLDILLGAWDEDDIKLSDADLRAEVDTFMFERHDTTTSGISWFLYCMXXXXXXXXXXXX 180

           DFLDILLGA DEDDIKLSDADLRAEVDTFMFE HDTTTSGISWFLYCM            

Sbjct: 284 DFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCM------------ 331

 

Query: 181 XXXXXXXXXXXXXXXXXXXXXXGPGLLPVDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 240

                                        DDLGKMTYLTMCIKESFRLYPPVPQVYRQLS

Sbjct: 332 ---ALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388

 

Query: 241 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDPLRFSTENASKRHPFAFMPFSA 300

           KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD LRFSTENASKRHPFAFMPFSA

Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448

 

Query: 301 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLCSKNGFHLHLKPLGPG 360

           GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL SKNGFHLHLKPLGPG

Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPG 508

 

Query: 361 SGK 363

           SGK

Sbjct: 509 SGK 511

 

 

>CYP4F2 NM_001082 revised exon 2 and C-terminal

          Length = 520

Human on bottom chimp from XP_512460 on top

 Score =  809 bits (2090), Expect = 0.0

 Identities = 394/407 (96%), Positives = 399/407 (98%)

Missing N-term 113 aa. 12 aa diffs in first part, missassembled from

Two genes, 4F11 and 4F2.

 

Query: 2   SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 61

           SAA+APKD  FY FL+PWLGDGLLLS GDKWSRHRRMLTPAFHFNILKPYMKIFN+SVNI

Sbjct: 114 SAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNI 173

 

Query: 62  MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSALVS 121

           MH KWQ LASEGSA LDMFEHISLMTLDSLQKCVFSF+S+CQEKPSEYIAAILELSALVS

Sbjct: 174 MHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVS 233

 

Query: 122 KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS 181

           KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS

Sbjct: 234 KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS 293

 

Query: 182 KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER 241

           KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER

Sbjct: 294 KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER 353

 

Query: 242 CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV 301

           CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV

Sbjct: 354 CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV 413

 

Query: 302 IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF 361

           IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF

Sbjct: 414 IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF 473

 

Query: 362 AMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 408

           AMAEMKVVLALTLL FRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS

Sbjct: 474 AMAEMKVVLALTLLAFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 520

 

 

>CYP4F3 NM_000896

human on bottom, chimp XP_512458 on top

 

partial seq, 3 aa diffs

 

 Score =  405 bits (1042), Expect = e-116

 Identities = 192/195 (98%), Positives = 193/195 (98%)

 

Query: 1   MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCM 60

           MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA LPFLTMC+

Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCI 385

 

Query: 61  KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 120

           KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF

Sbjct: 386 KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

 

Query: 121 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELV 180

           DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL FRVLPDHTEPRRKPELV

Sbjct: 446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELV 505

 

Query: 181 LRAEGGLWLRVEPLS 195

           LRAEGGLWLRVEPLS

Sbjct: 506 LRAEGGLWLRVEPLS 520

 

 

>CYP4F11 N-terminal is on AC011517 rest is on AC020950

          Length = 523

 

 Score =  204 bits (518), Expect = 7e-56

 Identities = 99/100 (99%), Positives = 99/100 (99%), Gaps = 1/100 (1%)

 

Top part of 4F2 above is really 4F11 as shown here, assembly error

 

Query: 2   SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 61

           SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFN LKPYMKIFNKSVNI

Sbjct: 114 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFN-LKPYMKIFNKSVNI 172

 

Query: 62  MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 101

           MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN

Sbjct: 173 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 212

 

 

>CYP4F9P AC004609 complement(13903-33104 region)

human on bottom, chimp XP_524145 on top

 

16 aa diffs

 Score =  545 bits (1403), Expect = e-157

 Identities = 296/453 (65%), Positives = 305/453 (67%), Gaps = 106/453 (23%)

 

Query: 111 PTGFKIWMNPITPIIRLCHPNIIRSVINAS------------------GDGLLVNAGDKW 152

           P GFKIWMNPITPIIRLCHPNII SVINAS                  GDGLLVNA DKW

Sbjct: 14  PQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKDEAFYKFLKPWLGDGLLVNASDKW 73

 

Query: 153 SRHRQMLMLTFHFNMLKPYMKFFTDSVNIMHAKWQLLASEGSAHLDMFEHTSLMTLDSRQ 212

           S HRQMLM  FHFNMLKPYMKFFTDSVNIMHAKWQLLAS GSAHLDMFEHTSLMTLDS Q

Sbjct: 74  SCHRQMLMPAFHFNMLKPYMKFFTDSVNIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQ 133

 

Query: 213 KCVFSFDSHCQD------------------------------------GWRFRRACCLVH 236

           KCVFSFDSHCQ+                                    GWRFRRACCLVH

Sbjct: 134 KCVFSFDSHCQEKPSQYIATILELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVH 193

 

Query: 237 DFTEAIIQEQRHTLTSQGVDYFHQVKAKSKTLDFIDVLLLSKDEDWKELSDEEIRAEADT 296

           DFTEAIIQEQRHTLTSQGVDYFH+VKAKSKTLDF DVLLLSK                  

Sbjct: 194 DFTEAIIQEQRHTLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXX 253

 

Query: 297 FMFEGHDTTASGLSWVLYNLARHPEYQEHCWQEPENPSISPRVLGD---SLYQMNDLAQL 353

               GH+TTASGLSWVLY LARHPEYQEHCWQE +      ++L D      + +DLAQL

Sbjct: 254 XXXXGHNTTASGLSWVLYYLARHPEYQEHCWQEVQ------KLLKDHEPKEIEXDDLAQL 307

 

Query: 354 PFLTMYIKDSLRLHPPVPVISRCYTRDI-------------------------------- 381

           PFLTMYIKDSL LHPPVPVISRC T+DI                               

Sbjct: 308 PFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLFSNFETHHNPTVWLDPE 367

 

Query: 382 VYDPFRFDPENSKERSPLAFIPFSAGSRQGWPVSEAGMGNCIGQAFAMAEMKVVLALTLL 441

           VYDPFRFDPENSKERSPLAFIPFSAGS            NCIGQAFAMAEMKVVLALTLL

Sbjct: 368 VYDPFRFDPENSKERSPLAFIPFSAGS-----------XNCIGQAFAMAEMKVVLALTLL 416

 

Query: 442 CFHVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS 474

           CF VCPDHMEPRRKPEVIMYAEGGLWLWVKPLS

Sbjct: 417 CFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS 449

 

 

>CYP4F10P human AD000685 exons 3-6 (cosmid ends in middle of exon 6) 80% to

human on bottom, chimp XP_524140 on top

 Score =  492 bits (1266), Expect = e-142

 Identities = 243/274 (88%), Positives = 245/274 (89%), Gaps = 16/274 (5%)

 

Pseudogene 16 aa diffs and retained intron, one stop codon difference

Question? Is this a full seq in chimp?

 

Query: 1 MSATIEPKDKVFYGFLKPWLCEDGLLLSAGDKWSCHRGMLMPAFHFNTLKPYMKIFDESVNI 62

           ATI PKDKVFY FLKPWL  DG LLSAGDKWSCHRGMLMPAFHFN LKPYMKIFDESVNI

Sbjct: 1   ATIAPKDKVFYSFLKPWL-GDGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNI 59

 

Query: 63  MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSLAA 122

           MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSL A

Sbjct: 60  MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSLVA 119

 

Query: 123 KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFTDAVIQEQRHTLPSQGVDDFLQAKAKS 182

           KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDF DA IQE+RHTLPSQGVDDFLQAKAKS

Sbjct: 120 KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADAAIQEKRHTLPSQGVDDFLQAKAKS 179

 

Query: 183 KTLDFIDVLLISKDEDGKELSDEDIKAEADTFMFEGEDPSEDQDVSSQGRGYDTRTSGLS 242

           KTLDFIDVLLISKDEDGKELSDEDI+  ADTFMFE               GYDTRTSGLS

Sbjct: 180 KTLDFIDVLLISKDEDGKELSDEDIRV*ADTFMFE---------------GYDTRTSGLS 224

 

Query: 243 WVQYNLAMHPEYQERCGQEMQEFLKVCEPKEIEW 276

           WVQYNLAMHPE QERCGQE QEFLKV EPKEIEW

Sbjct: 225 WVQYNLAMHPECQERCGQERQEFLKVWEPKEIEW 258

 

>CYP4F11 N-terminal is on AC011517 rest is on AC020950

N-term only

Human on bottom chimp XP_512461 on top

 Score =  246 bits (627), Expect = 6e-68

 Identities = 113/118 (95%), Positives = 113/118 (95%)

 

Only 2 aa diffs in this region

 

Query: 1   MPQLCLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

           MPQL LSWLGLGPVAASPWLLLLLVG SWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF

Sbjct: 1   MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

 

Query: 61  WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASGTRA 118

           WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSAS   A

Sbjct: 61  WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVA 118

 

 

>CYP4F12 mRNA for cytochrome P450, complete cds. AB035130 bottom,

chimp XP_524141 on top

 

 Score =  910 bits (2351), Expect = 0.0

 Identities = 445/470 (94%), Positives = 453/470 (96%), Gaps = 4/470 (0%)

 

13 amino acid differences and the wrong N-terminal in the automated assembly

 

Query: 16  PQNGTDWGSPG----PEEGLKDSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSITNAS 71

           P+    WG  G     EEGLKDSTQMSATYSQGFT+WLGPIIPFIVLCHPDTIRSITNAS

Sbjct: 55  PKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNAS 114

 

Query: 72  AAIALKDDLSIRFLKPWLGDGLLLSGVDKWSRHRRMLTPAFHFNILKSYITIFNKSANIM 131

           AAIA KD+L IRFLKPWLG+G+LLSG DKWSRHRRMLTPAFHFNILKSYITIFNKSANIM

Sbjct: 115 AAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIM 174

 

Query: 132 LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK 191

           LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK

Sbjct: 175 LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK 234

 

Query: 192 RNQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFLKDKAKSK 251

           R+QHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDF KDKAKSK

Sbjct: 235 RSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSK 294

 

Query: 252 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 311

           TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC

Sbjct: 295 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 354

 

Query: 312 RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI 371

           RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI

Sbjct: 355 RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI 414

 

Query: 372 PKGITCVINIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA 431

           PKGITC+I+IIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA

Sbjct: 415 PKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA 474

 

Query: 432 MAEMKVVLALMLLHFRFLPDHTEPRRKPELIMRAEGGLWLRVEHLNVGLQ 481

           MAEMKVVLALMLLHFRFLPDHTEPRRK ELIMRAEGGLWLRVE LNVGLQ

Sbjct: 475 MAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524

 

 

>CYP4F22 AC011492 assembled gene 13 exons 114537-140651 66% to 4F3,

human on bottom, chimp XP_512456 on top

 

5 aa diffs

 Score =  971 bits (2509), Expect = 0.0

 Identities = 486/531 (91%), Positives = 489/531 (92%), Gaps = 38/531 (7%)

 

Query: 19  MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 78

           MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP

Sbjct: 1   MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 60

 

Query: 79  QPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHNVLLVWMGPVLPLLVLVHPDYIKPLLG 138

           QPPRRNWLLGHLGM  PNEAGLQDEKKVLDNMH+VLLVWMGPVLPLLVLVHPDYIKPLLG

Sbjct: 61  QPPRRNWLLGHLGMVSPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLG 120

 

Query: 139 ASAAIAPKDDLFYGFLKPWLGEC-------KW---------------------------- 163

           ASAAIAPKDDLFYGFLKPWLG+        KW                           

Sbjct: 121 ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD 180

 

Query: 164 ---AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSHNSNCQEKMSDYISAIIELSALS 220

              AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS+NSNCQEKMSDYISAIIELSALS

Sbjct: 181 IMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALS 240

 

Query: 221 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRWALRQQGAEAWLKAKQG 280

           VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERR ALRQQGAEAWLKAKQG

Sbjct: 241 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG 300

 

Query: 281 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 340

           KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK

Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360

 

Query: 341 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 400

           CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI

Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 420

 

Query: 401 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 460

           IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF

Sbjct: 421 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 480

 

Query: 461 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 511

           AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA

Sbjct: 481 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 531

 

 

>CYP4V2 formerly CYP4AH1 AC012525 Homo sapiens chromosome 4

human on bottom, chimp XP_517565 on top

Assembly errors and 4 aa diffs

 

Score =  192 bits (487), Expect = 4e-51

 Identities = 105/150 (70%), Positives = 107/150 (71%), Gaps = 41/150 (27%)

 

Query: 113 MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVATYARKWQQMRPIPTVARAYPLV 172

           MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVA+YARKWQQMRPIPTVARAYPLV

Sbjct: 1   MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60

 

Query: 173 GHALLMKPDGRAQEGYFQTPALGLFPPHHCSALKALPFPPALAWEALGTEAPWEHKAIIE 232

           GHALLMKPDGR    +FQ                                       IIE

Sbjct: 61  GHALLMKPDGRE---FFQ--------------------------------------QIIE 79

 

Query: 233 YTEEYRHMPLLKLWVGPVPMVALYNAENVE 262

           YTEEYRHMPLLKLWVGPVPMVALYNAENVE

Sbjct: 80  YTEEYRHMPLLKLWVGPVPMVALYNAENVE 109

 

 Score = 78.2 bits (191), Expect = 9e-17

 Identities = 36/44 (81%), Positives = 38/44 (86%)

 

Query: 369 GWRTHTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANTLISSV 412

           G  T TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQAN L+  +

Sbjct: 134 GLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177

 

 Score =  621 bits (1601), Expect = e-180

 Identities = 316/365 (86%), Positives = 319/365 (87%), Gaps = 43/365 (11%)

 

Query: 501 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKIL 560

           ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSL+IL

Sbjct: 202 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQIL 261

 

Query: 561 HTFTNSGASKSKQKHVIIIQIIQVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 620

           HTFTNS                 VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL

Sbjct: 262 HTFTNS-----------------VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304

 

Query: 621 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 680

           SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV 

Sbjct: 305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV-- 362

 

Query: 681 MFGPFTGYIVHPPGLDTYLLSSGKSDRPATVEDLKKFRYLECVIKETLRLFPSVPLFARS 740

                                  KSDRPATVEDLKK RYLECVIKETLRLFPSVPLFARS

Sbjct: 363 -----------------------KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARS 399

 

Query: 741 VSEDCEV-AGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPKNAQGRHPYAYVPF 799

           VSED  + AGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFP+NAQGRHPYAYVPF

Sbjct: 400 VSEDYFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPF 459

 

Query: 800 SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 859

           SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR

Sbjct: 460 SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 519

 

Query: 860 NADER 864

           NADER

Sbjct: 520 NADER 524

 

>CYP4X1 R56515, R53456, AA652746, AC026935

human on bottom, chimp XP_513386 on top

missing C-helix, Only 2 aa diffs

 

 Score =  993 bits (2568), Expect = 0.0

 Identities = 486/506 (96%), Positives = 487/506 (96%), Gaps = 18/506 (3%)

 

Query: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

           MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF

Sbjct: 1   MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

 

Query: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

           IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFF IYDPDYAKTLLSRTDPKSQYLQKFSPPL

Sbjct: 61  IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

 

Query: 121 LG------------------TPGFHFNILKAYVEVMAHSVKMMLDKWEKICSTQDTSVEV 162

           LG                  TPGFHFNILKAY+EVMAHSVKMMLDKWEKICSTQDTSVEV

Sbjct: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180

 

Query: 163 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 222

           YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL

Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

 

Query: 223 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 282

           SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS

Sbjct: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300

 

Query: 283 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 342

           FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ

Sbjct: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360

 

Query: 343 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 402

           LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW

Sbjct: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420

 

Query: 403 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 462

           KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD

Sbjct: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480

 

Query: 463 PTRPLTFPNHFILKPKNGMYLHLKKL 488

           PTRPLTFPNHFILKPKNGMYLHLKKL

Sbjct: 481 PTRPLTFPNHFILKPKNGMYLHLKKL 506

 

 

>4Z2P AL731892.5 94% to 4Z1 1 stop codon in exon 8

human on bottom, chimp XP_513139 on bottom

might be 4Z1, hard to tell the two apart

 

16 aa diffs

 

Score =  222 bits (566), Expect = 2e-60

 Identities = 108/138 (78%), Positives = 113/138 (81%), Gaps = 2/138 (1%)

 

Query: 47  EPSWLRELMAQPFLLMILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPVHWFYGHKEFY 106

           EPSWL+ELMA PFLL+ILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPP HWFYGHKE Y

Sbjct: 2   EPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPAHWFYGHKEXY 61

 

Query: 107 PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQGLSYIRSN--LWSRQ 164

           PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQ      S+  L S 

Sbjct: 62  PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESWV 121

 

Score =  369 bits (948), Expect = e-104

 Identities = 183/211 (86%), Positives = 186/211 (88%), Gaps = 17/211 (8%)

 

Query: 408 ENTKDFSEADLQAEVKTFMFAGHDTTSSAIFWIFYCLAKYPEHQQRCRDEIRELLGDGSS 467

           ENTKDFSEADLQAEVKTFMFAGHDTT++AI WIFYCLAKYPEHQQRC DEIRELLGDGSS

Sbjct: 294 ENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSS 353

 

Query: 468 ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-----------------GITVFINIWALHH 510

           ITWEHLSQMPY TMCIKECLRLYAPVVNIS                 GITVFINIWALHH

Sbjct: 354 ITWEHLSQMPYATMCIKECLRLYAPVVNISQLLDKPITFPDGRSLPAGITVFINIWALHH 413

 

Query: 511 NPCFWEDPQVFNPLRFSRESSEKMHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRF 570

           NP FWE+PQVFNPLRFSRESSEKMHPYAFIPFSAG RNCIGQHFAII CKVAVALTLL F

Sbjct: 414 NPYFWENPQVFNPLRFSRESSEKMHPYAFIPFSAGPRNCIGQHFAIIGCKVAVALTLLCF 473

 

Query: 571 ELAPDYSRPSQPVRQMLLKSKNGIHVFAKKV 601

           ELAPDYSRP QPVRQMLLKSKNGIHVFAKKV

Sbjct: 474 ELAPDYSRPPQPVRQMLLKSKNGIHVFAKKV 504

 

 

>CYP5A1 NM_001061 this gene is 197000 bases long

human on bottom, chimp XP_519420 on top

 

Assembly errors, 6 aa diffs

 

Score =  243 bits (620), Expect = 2e-66

 Identities = 119/119 (100%), Positives = 119/119 (100%)

 

Query: 97  YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI 156

           YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI

Sbjct: 32  YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI 91

 

Query: 157 SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN 215

           SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN

Sbjct: 92  SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN 150

 

 Score =  166 bits (420), Expect = 3e-43

 Identities = 77/79 (97%), Positives = 78/79 (98%)

 

Query: 314 MVPLISQACNLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV 373

           MVPLISQAC+LLLAHLKRYAESGDAFDIQRCYCNYTTDVVASV FGTPVDSWQAPEDPFV

Sbjct: 152 MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPEDPFV 211

 

Query: 374 KHCKRFFEFCIPRPILVLL 392

           KHCKRFFEFCIPRPILVLL

Sbjct: 212 KHCKRFFEFCIPRPILVLL 230

 

 Score = 89.4 bits (220), Expect = 4e-20

 Identities = 44/45 (97%), Positives = 45/45 (100%)

 

Query: 521 VLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 565

           +LSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE

Sbjct: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 274

 

 Score =  527 bits (1357), Expect = e-152

 Identities = 258/277 (93%), Positives = 264/277 (95%)

 

Query: 624 KAAPKTVSLVQASTQAQRRRDFLQMVLDARHSASPMGVQDFDIVREVFSSTGCKPNPSRQ 683

           K     ++L       +RRRDFLQMVLDARHSASPMGVQDFDIVR+VFSSTGCKPNPSRQ

Sbjct: 258 KLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQ 317

 

Query: 684 HQPSSMARPLTVDEIVGQAFIFLIAGYEIVTNTLSFATYLLATNPDCQEKLLREVDVFKE 743

           HQPS MARPLTVDEIVGQAFIFLIAGYEI+TNTLSFATYLLATNPDCQEKLLREVDVFKE

Sbjct: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKE 377

 

Query: 744 KHMAPEFCSLKEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG 803

           KHMAPEFCSL+EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG

Sbjct: 378 KHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG 437

 

Query: 804 ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV 863

           ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV

Sbjct: 438 ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV 497

 

Query: 864 LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 900

           LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR

Sbjct: 498 LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534

 

 

>CYP7A1 NM_000780 human on bottom, chimp XP_519773 on top

          Length = 504

 

Only 3 aa diffs

 

 Score =  979 bits (2531), Expect = 0.0

 Identities = 482/504 (95%), Positives = 485/504 (96%), Gaps = 18/504 (3%)

 

Query: 1   MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60

           MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ

Sbjct: 1   MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60

 

Query: 61  RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120

           RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN

Sbjct: 61  RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120

 

Query: 121 TT------------------VTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 162

           TT                  +TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF

Sbjct: 121 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 180

 

Query: 163 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 222

           EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE

Sbjct: 181 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 240

 

Query: 223 SLRHENLQKRESVSELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 282

           SLRHENLQKRES+SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ

Sbjct: 241 SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300

 

Query: 283 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS 342

           MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL+SIIKESLRLSSAS

Sbjct: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLNSIIKESLRLSSAS 360

 

Query: 343 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 402

           LNIRTAKEDFTLHLEDGSYNIRKD IIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK

Sbjct: 361 LNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420

 

Query: 403 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 462

           TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD

Sbjct: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480

 

Query: 463 QSRAGLGILPPLNDIEFKYKFKHL 486

           QSRAGLGILPPLNDIEFKYKFKHL

Sbjct: 481 QSRAGLGILPPLNDIEFKYKFKHL 504

 

>CYP8A1 D83402 human on bottom, chimp XP_514713 on top

          Length = 500

 

Partial seq, 11 aa diffs

 

 Score =  900 bits (2326), Expect = 0.0

 Identities = 449/478 (93%), Positives = 452/478 (94%), Gaps = 16/478 (3%)

 

Query: 27  QSRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYITVLLDPHS 86

           ++RRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRY+TVLLDPHS

Sbjct: 23  RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 82

 

Query: 87  YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYT 146

           YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMK TLLHRELQALTEAMYT

Sbjct: 83  YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142

 

Query: 147 NLHTVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 206

           NLH VLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD

Sbjct: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 202

 

Query: 207 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLH 266

           VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLA RAHRSKWLESYLLH

Sbjct: 203 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 262

 

Query: 267 LEEMGVSEEMQARALVLQLWATQ----------------NPEPLAAFRGELESILWQAEQ 310

           LEEMGVSEEMQARALVLQLWATQ                NPE LAA RGELESILWQAEQ

Sbjct: 263 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 322

 

Query: 311 PVLQTPILPQKVLASTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 370

           PV QT  LPQKVL STPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR

Sbjct: 323 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 382

 

Query: 371 LLLFPFLSPQRDPEIYADPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 430

           LLLFPFLSPQRDPEIY DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL

Sbjct: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442

 

Query: 431 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 488

           GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

Sbjct: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500

 

>CYP11B2 NM_000498 human on bottom, chimp XP_519994 on top

          Length = 503

 

Partial seq, only 2 aa diffs

 

 Score =  592 bits (1526), Expect = e-171

 Identities = 295/336 (87%), Positives = 303/336 (90%)

 

Query: 367 RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM 426

           RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM

Sbjct: 33  RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM 92

 

Query: 427 LPEDVEKLQQVDSLHPRRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 486

           LPEDVEKLQQVDSLHP RMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK

Sbjct: 93  LPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 152

 

Query: 487 AVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 546

           AVQRFLPMVDAVARDFSQAL+KKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV

Sbjct: 153 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 212

 

Query: 547 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 606

           GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ

Sbjct: 213 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272

 

Query: 607 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTVRPATSPTQRGWLG 666

           KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDT       T     

Sbjct: 273 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332

 

 

>CYP17 NM_000102 human on bottom, chimp NP_001009052, Q8HYN1 AAN86251 on top

          Length = 508

 

2 aa diffs

 

 Score = 1023 bits (2644), Expect = 0.0

 Identities = 506/508 (99%), Positives = 508/508 (100%)

 

Query: 1   MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60

           MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY

Sbjct: 1   MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60

 

Query: 61  GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120

           GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH

Sbjct: 61  GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120

 

Query: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180

           WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS

Sbjct: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180

 

Query: 181 LICFNTSYKNGDPELNIIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240

           LICFNTSYKNGDPELN+IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN

Sbjct: 181 LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240

 

Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

           DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF

Sbjct: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

 

Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

           GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV

Sbjct: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

 

Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTQVIINLWALHHNEKEWHQPDQFMPERFLNP 420

           LRLRPVAPMLIPHKANVDSSIGEFAVDKGT+VIINLWALHHNEKEWHQPDQFMPERFLNP

Sbjct: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

 

Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

           AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP

Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

 

Query: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508

           KVVFLIDSFKVKIKVRQAWREAQAEGST

Sbjct: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508

 

 

>CYP19 NM_000103 human on bottom, chimp XP_510404 on top

          Length = 503

 

Only 2 aa diffs

 

 Score =  823 bits (2125), Expect = 0.0

 Identities = 423/503 (84%), Positives = 429/503 (85%), Gaps = 59/503 (11%)

 

Query: 1   MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60

           MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI

Sbjct: 1   MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60

 

Query: 61  SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120

           SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL

Sbjct: 61  SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120

 

Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKESA-----------------------IVVK 157

           GLQCIGMHEKGIIFNNNPELWKTTRPFFMK  +                        V 

Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180

 

Query: 158 IQGYFDAW----------------------QALLIKPDIFF--------------KISWL 181

             GY D                         A+++K   +F              KISWL

Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240

 

Query: 182 YKKYEKSVKDLKDAMEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 241

           YKKYEKSVKDLKDA+EVLIAEKR RISTEEKLEECMDFATELILAEKRGDLTRENVNQCI

Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300

 

Query: 242 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 301

           LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI

Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360

 

Query: 302 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 361

           YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK

Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420

 

Query: 362 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 421

           NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH

Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480

 

Query: 422 PDETKNMLEMIFTPRNSDRCLEH 444

           PDETKNMLEMIFTPRNSDRCLEH

Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503

 

 

>CYP20 AC011737.8 chr 2 (missing exons 12,13) AC080075.2 (missing exons

           1,7,8), human on bottom, chimp XP_516042 on top

assembly errors but only 2 aa diffs

 Score =  404 bits (1039), Expect = e-115

 Identities = 207/226 (91%), Positives = 211/226 (93%), Gaps = 3/226 (1%)

 

Query: 1   MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60

           MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN

Sbjct: 1   MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60

 

Query: 61  LHEKYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120

           LHE+YGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN

Sbjct: 61  LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120

 

Query: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180

           HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV

Sbjct: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180

 

Query: 181 MGSTFEDDQEVIRFQKNHGTVMCTWAICFLTTSEE---VQKKLYEE 223

           MGSTFEDDQEVIRFQKNHGTV       FL  S +    +KK YE+

Sbjct: 181 MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYED 226

 

 Score =  254 bits (648), Expect = 3e-70

 Identities = 146/254 (57%), Positives = 164/254 (64%), Gaps = 59/254 (23%)

 

Query: 115 GSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMK 174

           GS+ +N  RKK YE+ +   L+S    ++K             E +    SQH+     

Sbjct: 212 GSLDKNMTRKKQYEDALMQ-LESVLRNIIK-------------ERKGRNFSQHIF----- 252

 

Query: 175 SVTQMVMGSTFEDDQEVIRFQKNHGTV-------MCTWAICFLTTSEEVQKKLYEEINQV 227

            +  +V G+   +DQ+++                +CTWAICFLTTSEEVQKKLYEEINQV

Sbjct: 253 -IDSLVQGNL--NDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQV 309

 

Query: 228 FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQHQDIEGKIDQFIIPRETLVLYALG 287

           FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ QDIEGKID+FIIPRETLVLYALG

Sbjct: 310 FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALG 369

 

Query: 288 VVLQDPNTWPSPHKYEIFVIVFVTVSFCVCTFCIPFLSVEEKTQFDPDRFDDELVMKTFS 347

           VVLQDPNTWPSPHK                              FDPDRFDDELVMKTFS

Sbjct: 370 VVLQDPNTWPSPHK------------------------------FDPDRFDDELVMKTFS 399

 

Query: 348 SLGFSGTQECPELR 361

           SLGFSGTQECPELR

Sbjct: 400 SLGFSGTQECPELR 413

 

 

>CYP21A2 M26856 human on bottom, chimp XP_527350 on top

 

only 6 aa diffs

 

 Score =  922 bits (2383), Expect = 0.0

 Identities = 463/497 (93%), Positives = 467/497 (93%), Gaps = 19/497 (3%)

 

Query: 1   MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60

           MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY

Sbjct: 1   MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60

 

Query: 61  RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH 120

           RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVS+NYPDLSLGDYSLLWKAH

Sbjct: 61  RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120

 

Query: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180

           KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD

Sbjct: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180

 

Query: 181 KIKEDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRVSRSARSFHPLQA---------- 230

           KIK+DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR   +       QA         

Sbjct: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240

 

Query: 231 -------SLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGAAHVHMAVVDLLIGGTETTA 283

                  SLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG  HVHMA VDLLIGGTETTA

Sbjct: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG--HVHMAAVDLLIGGTETTA 298

 

Query: 284 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP 343

           NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP

Sbjct: 299 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP 358

 

Query: 344 VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR 403

           VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR

Sbjct: 359 VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR 418

 

Query: 404 ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ 463

           ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ

Sbjct: 419 ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ 478

 

Query: 464 VRLQPRGMGAHSPGQSQ 480

           VRLQPRGMGAHSPGQ+Q

Sbjct: 479 VRLQPRGMGAHSPGQNQ 495

 

 

>CYP24 NM_000782 human on bottom, chimp XP_514731 on top

 

 Score =  717 bits (1852), Expect = 0.0

 Identities = 367/410 (89%), Positives = 369/410 (90%), Gaps = 32/410 (7%)

 

Query: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTTGGETQNAAALPG 60

           MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLT GGETQNAAALPG

Sbjct: 1   MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

 

Query: 61  PTRWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

           PT WPLL SLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR

Sbjct: 61  PTSWPLLASLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

 

Query: 121 TESAYPQRLEIKPWKAYRDYREEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

           TES  PQRLEIKPWKAYRDYR+EGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN

Sbjct: 121 TESV-PQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 179

 

Query: 181 EVCRLGPAFLGLVLADFMGRIDELC--------------------ICLVLYEKRFGLLQK 220

           EV           LADFMGRIDELC                    ICLVLYEKRFGLLQK

Sbjct: 180 EV-----------LADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQK 228

 

Query: 221 NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNR 280

           NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQ HTLAWDTIFKSVKACIDNR

Sbjct: 229 NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQGHTLAWDTIFKSVKACIDNR 288

 

Query: 281 LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSHNPQVQ 340

           LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLS NPQVQ

Sbjct: 289 LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQ 348

 

Query: 341 QKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSIPFTTRTLD 390

           QKLLKEIQSVLPENQ PR EDLRNMPYLKACLKESMRLTP +PFTTRTLD

Sbjct: 349 QKLLKEIQSVLPENQRPREEDLRNMPYLKACLKESMRLTPGVPFTTRTLD 398

 

 

>CYP26A1 NM_000783 on bottom, chimp XP_507927 on top

          Length = 497

 

Only one amino acid difference plus some missing seq.

 

Query: 1  MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

          MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM

Sbjct: 1  MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

 

Query: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRP 87

          VLQRRKFLQMKRRKYGFIYKTHLFGRP

Sbjct: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRP 87

 

Missing sequence 88-145 in this automated assembly

 

 Score =  718 bits (1853), Expect = 0.0

 Identities = 351/354 (99%), Positives = 352/354 (99%)

 

Query: 89  YGREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD 148

           + REALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD

Sbjct: 144 FSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD 203

 

Query: 149 GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRTSEA 208

           GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLR SEA

Sbjct: 204 GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEA 263

 

Query: 209 GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL 268

           GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL

Sbjct: 264 GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL 323

 

Query: 269 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 328

           QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL

Sbjct: 324 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 383

 

Query: 329 NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV 388

           NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV

Sbjct: 384 NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV 443

 

Query: 389 GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI 442

           GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI

Sbjct: 444 GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI 497

 

 

>CYP26C1 AL358613.11 May 2, 2001 522 amino acids, 6 exons,

human on bottom, chimp XP_521563 on top

 

no diffs in aligned region

 

 Score =  333 bits (855), Expect = 7e-94

 Identities = 168/168 (100%), Positives = 168/168 (100%)

 

Query: 458 QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS 517

           QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS

Sbjct: 68  QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS 127

 

Query: 518 HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA 577

           HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA

Sbjct: 128 HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA 187

 

Query: 578 LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK 625

           LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK

Sbjct: 188 LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK 235

 

 Score =  148 bits (374), Expect = 4e-38

 Identities = 69/70 (98%), Positives = 69/70 (98%)

 

Query: 282 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 341

           MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG

Sbjct: 1   MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60

 

Query: 342 ETLHWLVQVS 351

           ETLHWLVQ S

Sbjct: 61  ETLHWLVQGS 70

 

 

>CYP27B1 NM_000785 human on bottom, chimp XP_509175 on top

          Length = 508

 

Only 2 aa diffs

 

 Score =  988 bits (2554), Expect = 0.0

 Identities = 506/587 (86%), Positives = 506/587 (86%), Gaps = 79/587 (13%)

 

Query: 225 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 284

           MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR

Sbjct: 1   MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 60

 

Query: 285 LHELQPERTDAHEIRKRRVEAGGGMATLGQSPSGLLAEGAALRCGDPADIVQVQGAARFG 344

           LHELQ                                               VQGAA FG

Sbjct: 61  LHELQ-----------------------------------------------VQGAAHFG 73

 

Query: 345 PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE 404

           PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE

Sbjct: 74  PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE 133

 

Query: 405 WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF 464

           WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF

Sbjct: 134 WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF 193

 

Query: 465 GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL 524

           GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL

Sbjct: 194 GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL 253

 

Query: 525 CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE 584

           CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE

Sbjct: 254 CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE 313

 

Query: 585 LLLAGVDTVRFSLRAVSRFQGLASADSGAIFLLQAIHYGHVSNTLSWALYELSRHPEVQT 644

           LLLAGVDT                                VSNTLSWALYELSRHPEVQT

Sbjct: 314 LLLAGVDT--------------------------------VSNTLSWALYELSRHPEVQT 341

 

Query: 645 ALHSEITAALSPGSSAYPPATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI 704

           ALHSEITAALSPGSSAYP ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI

Sbjct: 342 ALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI 401

 

Query: 705 IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA 764

           IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA

Sbjct: 402 IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA 461

 

Query: 765 ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 811

           ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR

Sbjct: 462 ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508

 

>CYP27C1 AC027142 43% identical to 27A1 assembled gene

human on bottom, chimp XP_525906 on top

 

3 aa diffs

 Score =  913 bits (2359), Expect = 0.0

 Identities = 466/522 (89%), Positives = 466/522 (89%), Gaps = 53/522 (10%)

 

Query: 1   MPGPRTLANLAEFFCRDGSSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR 60

           MPGPRTLANLAEFFCRDG SRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR

Sbjct: 74  MPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR 133

 

Query: 61  AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN 120

           AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN

Sbjct: 134 AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN 193

 

Query: 121 QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE 180

           QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE

Sbjct: 194 QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE 253

 

Query: 181 YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY 240

           YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY

Sbjct: 254 YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY 313

 

Query: 241 QMDRGRRVSGGLLTYLFLSQALTLPEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ 300

           QMDRGRRVSGGLLTYLFLSQALTL EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ

Sbjct: 314 QMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ 373

 

Query: 301 QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI 360

           QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI

Sbjct: 374 QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI 433

 

Query: 361 PKGQGSPCSLACSPGRVEVASHRWESLKGSTAFSVAAVTFGVQCGVGREGAAAILGTQLA 420

           PK                                                     GTQLA

Sbjct: 434 PK-----------------------------------------------------GTQLA 440

 

Query: 421 LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL 480

           LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL

Sbjct: 441 LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL 500

 

Query: 481 VVIQLLQHFEIKTSSQTKAVHAKTHGLLTPGGPIHVRFVNRK 522

           VVIQLLQHFEIKTSSQT AVHAKTHGLLTPGGPIHVRFVNRK

Sbjct: 501 VVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 542

 

 

>CYP39A1 AC008104 AL035670 note heme region exon corrected 1/18/02

human on bottom, chimp XP_518518 on top

Partial seq, only 2 aa diffs

 

 Score =  721 bits (1860), Expect = 0.0

 Identities = 364/447 (81%), Positives = 369/447 (82%), Gaps = 76/447 (17%)

 

Query: 35  RKNLRRPPCVKGWIPWIGVGFEFGKAPLEFIEKARIKF---------------------- 72

           RKNLRRPPC+KGWIPWIGVGFEFGKAPLEFIEKARIK+                     

Sbjct: 23  RKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGI 82

 

Query: 73  SLFI------------------ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE 114

           ++F+                  ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE

Sbjct: 83  NVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE 142

 

Query: 115 LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQAYDEDFE 174

           LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQ YDEDFE

Sbjct: 143 LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFE 202

 

Query: 175 YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM------------------ 216

           YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM                 

Sbjct: 203 YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKEN 262

 

Query: 217 ------------------VAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL 258

                             VAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL

Sbjct: 263 SPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL 322

 

Query: 259 EKLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP 318

           E LLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP

Sbjct: 323 ENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP 382

 

Query: 319 ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 378

           ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP

Sbjct: 383 ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 442

 

Query: 379 LPKQSYLHLVGVPQPEGQCRIEYKQRI 405

           LPKQSYLHLVGVPQPEGQCRIEYKQRI

Sbjct: 443 LPKQSYLHLVGVPQPEGQCRIEYKQRI 469

 

 

>CYP46 NM_006668 human on bottom, chimp XP_510158 on top

          Length = 500

 

100% identical in aligned regions

 

 Score =  971 bits (2510), Expect = 0.0

 Identities = 500/567 (88%), Positives = 500/567 (88%), Gaps = 67/567 (11%)

 

Query: 1   MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

           MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL

Sbjct: 1   MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

 

Query: 61  QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120

           QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL

Sbjct: 61  QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120

 

Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180

           FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM

Sbjct: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180

 

Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240

           QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL

Sbjct: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240

 

Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300

           REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF

Sbjct: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300

 

Query: 301 IAGIPSLRIRGEACIRLAQKEMLSSFIHLLIRYFLNMVLHLEDSSSPVSHETSANHLAFT 360

           IAG                                              HETSANHLAFT

Sbjct: 301 IAG----------------------------------------------HETSANHLAFT 314

 

Query: 361 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 420

           VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL

Sbjct: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374

 

Query: 421 EEETLIDGVRVPGNTPLLWLKRCQGNNLGTRDERTLCPQFSTYVMGRMDTYFEDPLTFNP 480

           EEETLIDGVRVPGNTPLL                     FSTYVMGRMDTYFEDPLTFNP

Sbjct: 375 EEETLIDGVRVPGNTPLL---------------------FSTYVMGRMDTYFEDPLTFNP 413

 

Query: 481 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 540

           DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ

Sbjct: 414 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 473

 

Query: 541 ATLKPLDPVLCTLRPRGWQPAPPPPPC 567

           ATLKPLDPVLCTLRPRGWQPAPPPPPC

Sbjct: 474 ATLKPLDPVLCTLRPRGWQPAPPPPPC 500

 

 

>CYP51 NM_000786 human on bottom, chimp XP_509606 on top

          Length = 509

 

Partial seq

 

 Score =  235 bits (600), Expect = 3e-65

 Identities = 111/114 (97%), Positives = 111/114 (97%)

 

Query: 8   KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVVGYT 67

           KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV GYT

Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYT 400

 

Query: 68  IPPGHQVCVSPTVNQRLKDSWVERLDFNPDCYLQDNPASGEKFAYVPFGAGCHR 121

           IPPGHQVCVSPTVNQRLKDSWVERLDFNPD YLQDNPASGEKFAYVPFGAG HR

Sbjct: 401 IPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHR 454

 

>CYP51 NM_000786 human on bottom, chimp XP_519193 on top

          Length = 509

 

 Score =  910 bits (2353), Expect = 0.0

 Identities = 444/446 (99%), Positives = 446/446 (100%)

 

Query: 179 VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 238

           VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL

Sbjct: 64  VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 123

 

Query: 239 FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK 298

           FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK

Sbjct: 124 FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK 183

 

Query: 299 ETKEYFQSWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA 358

           ETKEYF+SWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA

Sbjct: 184 ETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA 243

 

Query: 359 AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT 418

           AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT

Sbjct: 244 AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT 303

 

Query: 419 DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQL 478

           DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ+KCYLEQKTVCGENLPPLTYDQL

Sbjct: 304 DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQL 363

 

Query: 479 KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE 538

           KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE

Sbjct: 364 KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE 423

 

Query: 539 RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 598

           RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG

Sbjct: 424 RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 483

 

Query: 599 YFPTVNYTTMIHTPENPVIRYKRRSK 624

           YFPTVNYTTMIHTPENPVIRYKRRSK

Sbjct: 484 YFPTVNYTTMIHTPENPVIRYKRRSK 509

 

 

>CYP51P1 processed pseudogene U36926 5 in frame stops

human on bottom, chimp XP_516594 on top

 

 Score =  536 bits (1380), Expect = e-155

 Identities = 273/303 (90%), Positives = 278/303 (91%), Gaps = 18/303 (5%)

 

Query: 1   MEEVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSPIPFLGHAIAF 60

           MEEV GGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSP+PFLGHAIAF

Sbjct: 24  MEEVAGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSPVPFLGHAIAF 83

 

Query: 61  GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP 120

           GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP

Sbjct: 84  GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP 143

 

Query: 121 VFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKKHVSIIEKETKEYFESWGESGE------ 174

           VFG GVAYDVPNPVFLEQKK LKSGLNIAHFK HVSIIEKETKEYFESWGESGE     

Sbjct: 144 VFG*GVAYDVPNPVFLEQKKTLKSGLNIAHFK*HVSIIEKETKEYFESWGESGEKNVFAA 203

 

Query: 175 ------------MHGKEIRSQPNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAH 222

                       +HGKEIRSQ NEKVAQLYADLDGGFSHAAWLLPGWLPLP FRRRDRAH

Sbjct: 204 LSELIILTASHYLHGKEIRSQ