Chimpanzee P450s compared with human

62 sequences April 5, 2006

D. Nelson

>CYP1A1 NM_000499 human on bottom, chimp XP_510670 on top

Length = 512

Score = 560 bits (1442), Expect = e-162

Identities = 274/275 (99%), Positives = 275/275 (100%)

Partial seq, one aa diff

The rest of this seq is on chr16_random:21929790-21932380

There is only 1 aa diff in the whole seq

Query: 13 MLFPISMSATEFLLASVIFCLVFWVIRASRPRVPKGLKNPPGPWGWPLIGHMLTLGKNPH 72

MLFPISMSATEFLLASVIFCLVFWVIRASRP+VPKGLKNPPGPWGWPLIGHMLTLGKNPH

Sbjct: 1 MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60

Query: 73 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 132

LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS

Sbjct: 61 LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120

Query: 133 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 192

MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG

Sbjct: 121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180

Query: 193 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 252

PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL

Sbjct: 181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240

Query: 253 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 287

RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK

Sbjct: 241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275

>CYP1A2 NM_000761 human on bottom, chimp XP_510671 on top

Length = 515

Score = 959 bits (2480), Expect = 0.0

Identities = 475/483 (98%), Positives = 481/483 (99%), Gaps = 1/483 (0%)

8 amino acid differences, seq gap at end, missing 21 aa

Query: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN

Sbjct: 1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60

Query: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG

Sbjct: 61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120

Query: 121 QSMTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180

QS+TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM

Sbjct: 121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180

Query: 181 AGPGHFDPYNQVVMSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

AGPGHFDPYNQVV+SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP

Sbjct: 181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP 240

Query: 241 ILRYLPNPALQRFKAFNQRFLRFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGG 300

ILRYLPNPALQRFKAFNQRFL FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS G

Sbjct: 241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS-G 299

Query: 301 DLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 360

+LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL

Sbjct: 300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL 359

Query: 361 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFINQWQVNHDPE 420

SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF+NQWQVNHDPE

Sbjct: 360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419

Query: 421 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEVFLFLAILLQQL 480

LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE+FLFLAILLQQL

Sbjct: 420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479

Query: 481 EFS 483

EFS

Sbjct: 480 EFS 482

>CYP1B1 NM_000104

human on bottom, chimp XP_515417 on top

missing C-term, 2 aa diffs

Score = 550 bits (1417), Expect = e-159

Identities = 273/275 (99%), Positives = 274/275 (99%)

Query: 1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLGSAPPGPFAWPLI 60

MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQL SAPPGPFAWPLI

Sbjct: 1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

Query: 61 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120

GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F

Sbjct: 61 GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

Query: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL

Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

Query: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL

Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

Query: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK

Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275

>CYP1B1 NM_000104

human on bottom, chimp XP_515416 on top

C-term part, 3 aa diffs

Score = 348 bits (892), Expect = 7e-99

Identities = 169/172 (98%), Positives = 170/172 (98%)

Query: 1 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 60

MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP

Sbjct: 372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431

Query: 61 VKWPNPENFDPARFLDKDGFINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 120

VKWPNPENFDPARFLDKDG INKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC

Sbjct: 432 VKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 491

Query: 121 NFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAKETCQ 172

+FRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQAKETCQ

Sbjct: 492 DFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ 543

>CYP2A7v1 wild type AC008537.3 Exon 8 is different from U22029

Length = 494

Human on bottom, chimp XP_524272 on top

Only 2 aa diffs in aligned region

Score = 206 bits (523), Expect = 4e-56

Identities = 105/116 (90%), Positives = 106/116 (91%), Gaps = 9/116 (7%)

Query: 36 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE 95

QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQ

Sbjct: 218 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ- 276

Query: 96 VHPSSQCGEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 151

EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE

Sbjct: 277 --------EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE 324

>CYP2A13 U22028 human on bottom, chimp XP_512681 on top

partial seq, one aa diff

Score = 380 (133.8 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

Identities = 73/73 (100%), Positives = 73/73 (100%)

Query: 227 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 286

GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR

Sbjct: 302 GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361

Query: 287 FGDMLPMGLAHRV 299

FGDMLPMGLAHRV

Sbjct: 362 FGDMLPMGLAHRV 374

Score = 263 (92.6 bits), Expect = 1.1e-66, Sum P(2) = 1.1e-66

Identities = 56/68 (82%), Positives = 57/68 (83%)

Query: 22 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQVTGCSPP 81

ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLG FQFT TSTGQ+

Sbjct: 166 ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQLYEMFSS 225

>CYP2A18PN = CYP2A7PT U22030 and 2A7PC U22044, human on bottom,

chimp XP_524273 on top

Length = 275

Pseudogene with only one aa diff in aligned region

Score = 287 bits (734), Expect = 4e-80

Identities = 188/354 (53%), Positives = 207/354 (58%), Gaps = 81/354 (22%)

Query: 1 MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTESVSAMAPC 60

MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTE +

Sbjct: 1 MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTEHICDSIMK 60

Query: 61 SPFTWGPGGSWCCADMMPSRRLWWTRLRSSAGEVSRPPSTGSSKAVLLFFSVFLLCPLTS 120

+GP + ++ + + + S +A +

Sbjct: 61 ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWL---------- 110

Query: 121 PSSSSVLGFRG--VTCRTWERTKPLRRFSIATLRDFGVGKRGIKEVSRRRRASSSRPSRA 178

F+G VTCRTWERTKPLRRFSIATLRDFGVGKRGIKE+ +

Sbjct: 111 --------FKGYGVTCRTWERTKPLRRFSIATLRDFGVGKRGIKEIQEK------AGFLI 156

Query: 179 RAVSRTPRVWRREKENTQGEEPARVLSSIDPTFFLSRTTSNVISSIVFGDRFDYEDKSSC 238

+AV T+G SSI PTFFLSRTTSNVISSIVFGDRFDYEDK

Sbjct: 157 KAV-----------*GTRG-------SSIYPTFFLSRTTSNVISSIVFGDRFDYEDK--- 195

Query: 239 KHLNRYPFLFNIFTSPTLIPEHLNKSPQSRPNKSHSHQFLPPDSSPSLPILSLQPQLYEM 298

K L+ + F QF P + +LYEM

Sbjct: 196 KFLSLLCMMLESF------------------------QFTAPSTG----------ELYEM 221

Query: 299 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 352

FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ

Sbjct: 222 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 275

>CYP2B6 AC023172.1 CDS (hIIB1) cryptic exon 3A = 18813-18856 (hIIB2)

human on bottom, chimp XP_512679 on top

Score = 471 bits (1211), Expect = e-135

Identities = 232/245 (94%), Positives = 240/245 (97%)

13 differences in a partial sequence, missing about 160 aa

Query: 1 MLCGVEAIREALVDKAEAFSGRGKIAIMDPVYQGYGVLFANGNRWKVLRRFSVTIMRDFG 60

MLCGVEAIREALVDKAEAFSGRGKIA++DP ++GYGV+FANGNRWKVLRRFSVT MRDFG

Sbjct: 77 MLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG 136

Query: 61 MGKRSVEERIQDEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 120

MGKRSVEERIQ+EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL

Sbjct: 137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL 196

Query: 121 KMLNLFYQTFSLISSISSQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 180

KMLNLFYQTFSLISS+ QLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL

Sbjct: 197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL 256

Query: 181 DPSAPKDLIDTYLLHMEKEKSDAHSEFSHQNLTLNTLSLFFAGTETTSTTLRYGFLLMLK 240

DPSAPKDLIDTYLLHMEKEKS+AHSEFSHQNL LNTLSLFFAGTETTSTTLRYGFLLMLK

Sbjct: 257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK 316

Query: 241 YPHVA 245

YPHVA

Sbjct: 317 YPHVA 321

>CYP2C8 M17397 human on bottom, chimp XP_508183 on top

Length = 490

12 aa diffs

Score = 111 bits (278), Expect = 4e-27

Identities = 53/56 (94%), Positives = 54/56 (96%)

Query: 1 MEPFVVLVLCLSFMLLFSLWRQSSGRRKLPPGPTPLPIIGNMLQIDVKDICKSFSN 56

MEPFVVLVLCLSFMLLFSLWRQS RRKLPPGPTPLPIIGNMLQIDVKDICKSF+N

Sbjct: 1 MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTN 56

Score = 858 bits (2217), Expect = 0.0

Identities = 422/442 (95%), Positives = 426/442 (96%), Gaps = 8/442 (1%)

Query: 120 FSKVYGPVFTVYFGMNPIVVLHGYEAVKEALIDNGEEFSGRGSSPISQRITKGLGIISSN 179

FSKVYGPVFTVYFGMNPIVV HGYEAVKEALIDNGEEFSGRG+SPISQRITKGLGIISSN

Sbjct: 57 FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116

Query: 180 GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 239

GKRWKEIRRFSLT LRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN

Sbjct: 117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN 176

Query: 240 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLTN 299

VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVL N

Sbjct: 177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236

Query: 300 VALTQSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 359

VALT+SYIREKVKEHQASLDVNNPRDF+DCFLIKMEQEKDNQKSEFNIENLVGTVADLFV

Sbjct: 237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV 296

Query: 360 AGTETTSTTLRYGLLLLLMHPEVTAKVQEEIDHVIGRHRTPCMQDRSHMPYTDAVVHEIQ 419

AGTETTSTTLRYGLLLLL HPEVTAKVQEEIDHVIGRHR+PCMQDRSHMPYTDAVVHEIQ

Sbjct: 297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356

Query: 420 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMTLLTSVLHDDKEFPNPNIFDPGHFLDKN 479

RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIM LLTSVLHDDKEFPNPNIFDPGHFLDKN

Sbjct: 357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416

Query: 480 GNFKKSDYFMPFSAGNRNSFPFENEFAAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 539

GNFKKSDYFMPFSAG R AGEGLARMELFLFLTTILQNFNLKSVDDLKNLN

Sbjct: 417 GNFKKSDYFMPFSAGKR--------ICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN 468

Query: 540 TTAVTKGIVSLPPSYQICFIPV 561

TTAVTKGIVSLPPSYQICFIPV

Sbjct: 469 TTAVTKGIVSLPPSYQICFIPV 490

>CYP2C9 M61857 human on bottom, chimp XP_507939 on top

Length = 490

Score = 947 bits (2447), Expect = 0.0

Identities = 472/490 (96%), Positives = 476/490 (97%), Gaps = 8/490 (1%)

Small disagreement on assembly, otherwise only 3 aa diffs

Query: 1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNVSML 60

MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTN+S +

Sbjct: 1 MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60

Query: 61 ------LQWLAK--VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 112

L + K VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW

Sbjct: 61 YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW 120

Query: 113 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 172

KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS

Sbjct: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180

Query: 173 IIFHKRFDYKDQQFLNLMEKLNENVKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 232

IIFHKRFDYKDQQFLNLMEKLNEN+KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM

Sbjct: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240

Query: 233 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 292

KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE

Sbjct: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300

Query: 293 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 352

TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID

Sbjct: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360

Query: 353 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 412

LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK

Sbjct: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420

Query: 413 KSNYFMPFSAGKRICVGEALARMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 472

KS YFMPFSAGKRICVGEALA MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP

Sbjct: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480

Query: 473 PFYQLCFIPV 482

PFYQLCFIPV

Sbjct: 481 PFYQLCFIPV 490

>CYP2C19 M61854 human on bottom, chimp XP_507938 on top

Missing N-term, only 4 aa diffs

Score = 774 bits (1998), Expect = 0.0

Identities = 392/425 (92%), Positives = 393/425 (92%), Gaps = 26/425 (6%)

Query: 1 MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 60

MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN

Sbjct: 74 MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133

Query: 61 FGMGKRSIEDRVQEEARCLVEELR------------------NVICSIIFQKRFDYKDQQ 102

FGMGKRSIEDRVQEEARCLVEELR NVICSIIFQKRFDYKDQQ

Sbjct: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ 193

Query: 103 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMERDILEKVKEHQE 162

FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME DILEKVKEHQE

Sbjct: 194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253

Query: 163 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 222

SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL

Sbjct: 254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313

Query: 223 LKHPEVTVLTRVLSAKVQEEIERVIGRKPEPCCMQDRGHMPYTDAVVHEVQRYIDLLPTS 282

LKHPEVT AKVQEEIERVIGR PC MQDRGHMPYTDAVVHEVQRYIDL+PTS

Sbjct: 314 LKHPEVT-------AKVQEEIERVIGRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTS 365

Query: 283 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDKKEFPNPEMFDPRHFLDEGGNFKKSNYF 342

LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD KEFPNPEMFDPRHFLDEGGNFKKSNYF

Sbjct: 366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425

Query: 343 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGLASVPPFYQL 402

MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG ASVPPFYQL

Sbjct: 426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485

Query: 403 CFIPV 407

CFIPV

Sbjct: 486 CFIPV 490

>CYP2D6 NM_000106 human on bottom, chimp Q2XNC8, ABB77911 on top

swissprot entry, best annotation

8 aa diffs

Score = 995 bits (2572), Expect = 0.0

Identities = 489/497 (98%), Positives = 494/497 (99%)

Query: 1 MGLEALVPLAVIVTIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

MGLEALVPLAVIV IFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ

Sbjct: 1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ 60

Query: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF

Sbjct: 61 LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120

Query: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK

Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180

Query: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAIPVLLHIPALAGKV 240

AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNA+PVLLHIPALAGKV

Sbjct: 181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240

Query: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA

Sbjct: 241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300

Query: 301 DLFSAGIVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVI 360

DLFSAG+VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA MPYTTAVI

Sbjct: 301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360

Query: 361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVWEKPFRFHPEHF 420

HEVQRFGDIVPLG+THMTSRDIEVQGFRIPKGTTL TNLSSVLKD+AVWEKPFRFHPEHF

Sbjct: 361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420

Query: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV

Sbjct: 421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480

Query: 481 FAFLVTPSPYELCAVPR 497

FAFLV+PSPYELCAVPR

Sbjct: 481 FAFLVSPSPYELCAVPR 497

>CYP2D8P1 = CYP2D8P AL021878 comp(55779-60892)

human on bottom, chimp XP_520854 (2D42) on top

9 aa diffs

Score = 213 bits (543), Expect = 1e-58

Identities = 110/119 (92%), Positives = 111/119 (93%)

Query: 1 MLNVVPLLLRIPGLAGKVLCSQKAFLTQLDELLTEHRMIWDPAQPPGDLTEAFLAEMEKA 60

MLNVVPLLLRIPGLAGKVL SQKAFLTQLDELLTEHRMIWDPA PP DLTEAFLAE EKA

Sbjct: 222 MLNVVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMIWDPA*PPRDLTEAFLAEKEKA 281

Query: 61 KGNPESSFNDENLCMVVADLFLAGMVTTSVTLAWGLLLMILHPDVQRRVQQIDNVIGQV 119

KGNPESSFNDENL MVVADLF AGMVTTS+TLAWGLLLMIL PDVQ RVQQIDNVIGQV

Sbjct: 282 KGNPESSFNDENLRMVVADLFFAGMVTTSITLAWGLLLMILRPDVQARVQQIDNVIGQV 340

>CYP2E1 J02843 human bottom chimp XP_508139 top

Length = 493

Score = 658 bits (1698), Expect = 0.0

Identities = 318/322 (98%), Positives = 321/322 (99%)

7 amino acid differences plus a gap of 25 amino acids

Query: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL

Sbjct: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60

Query: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP

Sbjct: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120

Query: 121 TWKDIRRFSLTTLRNYGMGKEGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

TWKDIRRFSLTTLRNYGMGK+GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI

Sbjct: 121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI 180

Query: 181 ADILFRKHFDYDDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSVLHYLPGSHRKVIKNVA 240

ADILFRKHFDY+DEKFLRLMYLFNENFHLLSTPWLQLYNNFPS LHYLPGSHRKVIKNVA

Sbjct: 181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240

Query: 241 EIKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

E+KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG

Sbjct: 241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG 300

Query: 301 TETTSTTLRYGLLILMKYPEIE 322

TETTSTTLRYGLLILMKYPEIE

Sbjct: 301 TETTSTTLRYGLLILMKYPEIE 322

Sequence gap

Query: 741 PYMDAVVHDVQRFITLVPSNLPLEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 800

PYMDAVVH++QRFITLVPSNLP EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE

Sbjct: 348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE 407

Query: 801 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 860

KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK

Sbjct: 408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467

Query: 861 DIDLSPIHIGFGCIPPRYKLCVIPRS 886

DIDLSPIHIGFGCIPPRYKLCVIPRS

Sbjct: 468 DIDLSPIHIGFGCIPPRYKLCVIPRS 493

>2F1P AC008537.3 93% identical to 2F1

human on bottom, chimp XP_512682 on top

4 aa diffs

Score = 327 bits (838), Expect = 2e-92

Identities = 157/168 (93%), Positives = 159/168 (94%)

Query: 96 GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYNIFP 155

GEPFDPTFVLSRS SNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELY+IFP

Sbjct: 1 GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFP 60

Query: 156 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIDCFLTKMAEKKEDPLS 215

SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI CFLTKMAEKKEDPLS

Sbjct: 61 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLTKMAEKKEDPLS 120

Query: 216 HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLALMKYPKVQGTLAHTCN 263

HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLA MKYPKVQ + N

Sbjct: 121 HFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQAHVQEEIN 168

>CYP2G2P AC008962 comp(28700-40696) seq of gene has two in frame stop codons

human on bottom, chimp XP_512680 on top

Pseudogene in human. Is it a pseudogene in chimp?

Score = 493 bits (1268), Expect = e-142

Identities = 267/344 (77%), Positives = 274/344 (79%), Gaps = 50/344 (14%)

Query: 1 MEMGGAVTIFLALCLSCLLILIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

MEMGGAVTIFLALCLSCLLILIAWK MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK

Sbjct: 1 MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK 60

Query: 61 LREKYGTVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIEQNFQGHELNTAR 120

LREKY VFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASI+QNFQGH

Sbjct: 61 LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGH------ 114

Query: 121 GGRQKPETEILAGVALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEASYLLEEFRK 180

GVALANGERWRIL RF LTILRDFGMGKRSIEERIQEEASYLLEEFRK

Sbjct: 115 ------------GVALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRK 162

Query: 181 TKVG-----FLSESWVRPLFG--------------FLLIL-------------FSALYDM 208

TK FL V + FL +L ++ LYDM

Sbjct: 163 TKGAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQLYDM 222

Query: 209 YSGIMQHLPGRHNRIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKNKP 268

YSGIMQ+LPGRHN IYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKN P

Sbjct: 223 YSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMHQDKNNP 282

Query: 269 YTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEAQ 312

TEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEA+

Sbjct: 283 RTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVEAK 326

Score = 160 bits (405), Expect = 9e-42

Identities = 85/109 (77%), Positives = 88/109 (80%), Gaps = 18/109 (16%)

Query: 324 GSRPVVVLCGHEAVKEALIDQADDFSGRGELASIEQNFQGHELNTARGGRQKPETEILAG 383

G RPVVVLCGHEAVKEAL+DQAD+FSGRGELASI+QNFQGH G

Sbjct: 74 GPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGH------------------G 115

Query: 384 VALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK 432

VALANGERWRIL RF LTILRDFGMGKRSIEERIQEEASYLLEEFRKTK

Sbjct: 116 VALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK 164

Score = 227 bits (579), Expect = 6e-62

Identities = 113/128 (88%), Positives = 115/128 (89%), Gaps = 2/128 (1%)

Query: 432 KRLVDIVPMGVPHNIIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFCYPDAFYPQHFLDE 491

+RLVDIVPMGVPHN+IRDTQFRGYLLPKGTDVFPLLGSVLKDPKYF YPDAFYPQHFLDE

Sbjct: 360 QRLVDIVPMGVPHNLIRDTQFRGYLLPKGTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDE 419

Query: 492 QGRFKKNEAFVPFSS--GKRICLGEAMARMELFLYFTSTLQNFSLHSLVPLADIDITPKA 549

QGRFKKNEAFVPFSS GKRICLGEAM RMELFLYFTSTLQNFSLHSLVP DIDITPK

Sbjct: 420 QGRFKKNEAFVPFSSGRGKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKL 479

Query: 550 LRLWQHPP 557

PP

Sbjct: 480 SGFGNIPP 487

>CYP2J2 NM_000775 chr 1 human on bottom, chimp XP_513445 on top

Length = 497

Missing the C-helix region, yellow areas are intron boundary diffs

Score = 937 bits (2423), Expect = 0.0

Identities = 471/501 (94%), Positives = 473/501 (94%), Gaps = 23/501 (4%)

7 aa diffs

Query: 1 MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60

MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD

Sbjct: 1 MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVD 60

Query: 61 FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPIREHI 120

FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTP+REHI

Sbjct: 61 FEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHI 120

Query: 121 FK------------------TLTALRNFGLGKKSLEERIQEEAQHLTEAIKKENGQPFDP 162

FK TLTALRNFGLGKKSLEERIQEEAQHLTEAIK+ENGQPFDP

Sbjct: 121 FKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDP 180

Query: 163 HFKINKAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 222

HFKIN AVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL

Sbjct: 181 HFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFL 240

Query: 223 PGPHQTLFSNWKKLKLFVSHMIDKHRKDRNPAETRDFIDAYLKEMS-HTGNPTSSFHEEN 281

PGPHQTLFSNWKKLKLFVSHMIDKHRKD NPAETRDFIDAYLKEMS HTGNPTSSFHEEN

Sbjct: 241 PGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEEN 300

Query: 282 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQGEHVEKVQAEIDRVIGQGQQPSTAAR 341

LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ EKVQ EIDRVIGQGQQPSTAAR

Sbjct: 301 LICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ----EKVQVEIDRVIGQGQQPSTAAR 356

Query: 342 ESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTYLTALHRDPTEWA 401

ESMPYTNAVIHEVQRMGNIIP NVPREVTVDTTLAGYHLPKGTMILT LTALHRDPTEWA

Sbjct: 357 ESMPYTNAVIHEVQRMGNIIPQNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWA 416

Query: 402 TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 461

TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN

Sbjct: 417 TPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNN 476

Query: 462 EKLSLKFRMGITISPVSHRLC 482

EKLSLKFRMGITISPVSHRLC

Sbjct: 477 EKLSLKFRMGITISPVSHRLC 497

>CYP2R1 Mikael Oscarson AC090835.6 Homo sapiens chromosome 11

human on bottom, chimp XP_508301 on top

N-term only, one aa diff

Score = 154 bits (389), Expect = 2e-40

Identities = 74/76 (97%), Positives = 75/76 (98%)

Query: 40 MWKLWRAEEGAAALGCALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 99

MWKLWRAEEGAAALG ALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE

Sbjct: 1 MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE 60

Query: 100 LPHVYMRKQSQVYGE 114

LPHVYMRKQSQVYGE

Sbjct: 61 LPHVYMRKQSQVYGE 75

>CYP2R1 Mikael Oscarson AC090835.6 Homo sapiens chromosome 11

human on bottom chimp XP_508300 on top

Score = 335 bits (858), Expect = 5e-95

Identities = 157/158 (99%), Positives = 157/158 (99%)

C-term only, 1 aa diff

Query: 1 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 60

MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN

Sbjct: 344 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 403

Query: 61 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEQLARMEMFLFFT 120

LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGE LARMEMFLFFT

Sbjct: 404 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFT 463

Query: 121 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 158

ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR

Sbjct: 464 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 501

>CYP2S1 AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13

human on bottom, chimp XP_512683 on top

Missing C-term Only 4 aa diffs

Score = 592 bits (1527), Expect = e-172

Identities = 296/300 (98%), Positives = 298/300 (99%)

Query: 1 MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL

Sbjct: 1 MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRL 60

Query: 61 SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN

Sbjct: 61 SKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN 120

Query: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGGPFDPSMLVAQATSN 180

GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEG PFDPS+L+AQATSN

Sbjct: 121 GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180

Query: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH

Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHH 240

Query: 241 VSTLAAFTVRQVQQHQGNLDALGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

VSTLAAFTVRQVQQHQGNLDA GPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL

Sbjct: 241 VSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLL 300

>CYP2T2P AC008537 human on bottom, chimp XP_512678 on top

Length = 457

Only 4 aa diffs in aligned regions

Score = 205 bits (522), Expect = 2e-55

Identities = 124/216 (57%), Positives = 130/216 (60%), Gaps = 53/216 (24%)

Query: 207 GGRNSGFVKLSGRWGRVFTVRLGPRPAVVLCGYAALRDALVLQADAVSGRGSMAVFERFT 266

GG + LSGRWGRVFTVRLGPRPAV LCGYAALRDALVLQADAVSGRGSMAVFERFT

Sbjct: 26 GGLDRALHSLSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFT 85

Query: 267 RGNS------------------------------EAPALDLPARTLQAGREPRLTPCGYW 296

RGN EA L+ A L + P

Sbjct: 86 RGNGILFSNRPCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATIGAPFDPV 145

Query: 297 IMLYPMLS----VLVFGNRYGYGDPEFLRLLNLFSDNFRIISSRWGE------------- 339

+L +S LVFGNRY YGDPEFLRLLNLFSDNF IISSRWGE

Sbjct: 146 RLLDNAVSNVICSLVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRI 205

Query: 340 ------LRVISEQIQRHWQMRQPAEPRDFIDCVTRW 369

LRVISEQIQRHWQMRQPAEPRDFIDC+TRW

Sbjct: 206 FRNFSELRVISEQIQRHWQMRQPAEPRDFIDCLTRW 241

>CYP2U1 AC096564.3 missing last exon, last exon from AC000016.1

human on bottom chimp XP_526649 on top

partial assembly, missing C-term/ N-term is too long, retained intron

There is a known GC boundary after SENT so that is why the program

Did not find the C-term. Only one aa diff

Score = 863 bits (2229), Expect = 0.0

Identities = 428/447 (95%), Positives = 428/447 (95%), Gaps = 18/447 (4%)

Query: 53 MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 112

MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP

Sbjct: 1 MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 60

Query: 113 PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 172

PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF

Sbjct: 61 PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 173 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGEREVVGCGYADAADES 232

FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKG

Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKG---------------- 164

Query: 233 PGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHREDPFCPFS 292

VVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKH EDPFCPFS

Sbjct: 165 --VVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFS 222

Query: 293 IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG 352

IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG

Sbjct: 223 IISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFG 282

Query: 353 PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL 412

PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL

Sbjct: 283 PFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYL 342

Query: 413 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 472

FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY

Sbjct: 343 FYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPY 402

Query: 473 TEATIMEVQRLTVVVPLAIPHMTSENT 499

TEATIMEVQRLTVVVPLAIPHMTSENT

Sbjct: 403 TEATIMEVQRLTVVVPLAIPHMTSENT 429

>CYP2W1 AC073957.7 chromosome 7 clone RP11-449P15 40% to 2F1

human on bottom chimp XP_518926 on top

Partial seq, only 3 aa diffs

Score = 645 bits (1663), Expect = 0.0

Identities = 322/325 (99%), Positives = 323/325 (99%)

Query: 1 MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF 60

MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF

Sbjct: 57 MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFF 116

Query: 61 SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS 120

SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS

Sbjct: 117 SSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPS 176

Query: 121 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK 180

NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK

Sbjct: 177 NITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRK 236

Query: 181 IEEVRAILRTLLEARRPHMCVGDPVRSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA 240

IEEVRAILRTLLEARRPH+C GDPV SYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA

Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMA 296

Query: 241 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 300

GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR

Sbjct: 297 GTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQR 356

Query: 301 FITLLPHVPRCTAADTQLGGFLLPK 325

FITLLPHVPRCTAADTQLGGFLLPK

Sbjct: 357 FITLLPHVPRCTAADTQLGGFLLPK 381

>CYP2AB1P = old 2D31P chr3q27.1 185030751-185015757 - strand build 33

human on bottom, chimp XP_526403 on top

10 aa diffs

Score = 556 bits (1434), Expect = e-161

Identities = 310/437 (70%), Positives = 324/437 (74%), Gaps = 70/437 (16%)

Query: 17 LHKATT-RLVQSVFTVWVGPIPVAVLSGFQAVKEALVSNSEQFSGRSLTPLFQDLFGERG 75

LH T +L QSVFTVWVGPIPVAVLSGFQ VKEALVSNSEQFSGRSLTPLFQDLFGERG

Sbjct: 50 LHPETLLQLAQSVFTVWVGPIPVAVLSGFQVVKEALVSNSEQFSGRSLTPLFQDLFGERG 109

Query: 76 IICSSGHTWRQKRRFCLVMIXGLGLGKLALEVQLQKEAAELAEAFRQEQG----PHQEIF 131

IICSSGHTWRQKRRFCLVMI GLGLGKLALEVQLQKEAAELAEAFRQEQG P I

Sbjct: 110 IICSSGHTWRQKRRFCLVMI*GLGLGKLALEVQLQKEAAELAEAFRQEQGRPFDPQVSIV 169

Query: 132 R---------------------YQEVVRSL---------------------IC------Q 143

R +QE+ +++ +C Q

Sbjct: 170 RSTVRVIGALVFGHHFLLEDPIFQELTQAIDFGLAFVSTVWRRLYDVFPWALCHLPGPHQ 229

Query: 144 EITR---------------HKLRAPEAPMDFISCYLAQISKAMDDPVSTFNQENLVKVVI 188

EI R HKLRAPEAP DFISCYLAQISKAMDDPVSTFNQENLV VVI

Sbjct: 230 EIFRYQEVVLSLIHQEITRHKLRAPEAPRDFISCYLAQISKAMDDPVSTFNQENLV*VVI 289

Query: 189 DLFLGGTDTTATTLCWALIHMIQHRAVQG--ERPLVTLWLTAQCMGLLDHGHCLHRSPCS 246

DLFLGGTDTTATTLCWALIHMIQH AVQG + L + A + D +

Sbjct: 290 DLFLGGTDTTATTLCWALIHMIQHGAVQGTVQLELDEVLGAAPVVCYEDRKRLPYTXAVL 349

Query: 247 VAPGRLSSVVAVGAVRQCVTSTRVCSYPMSKGTIILPNLASVLYDPESWETPRQFNPGHF 306

RLSSV+A+GAVRQCVTSTRVCSYP+SKGTIILPNLASVLYDPE WETPRQFNPGHF

Sbjct: 350 HDVQRLSSVMAMGAVRQCVTSTRVCSYPVSKGTIILPNLASVLYDPECWETPRQFNPGHF 409

Query: 307 SDKDANFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI 366

SDKD NFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI

Sbjct: 410 SDKDGNFVANEAFLPFSAGHRVYPADQLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYI 469

Query: 367 FGGTWQPQPQEICAVPR 383

FGGTWQPQPQEICAVPR

Sbjct: 470 FGGTWQPQPQEICAVPR 486

>CYP3A4 J04449 human on bottom, chimp XP_519243 on top

Length = 502

N-term only, 7aa diffs

Score = 345 bits (886), Expect = 3e-98

Identities = 167/174 (95%), Positives = 172/174 (98%)

Query: 1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYRKGFCMF 60

MA+IPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY KGFCMF

Sbjct: 1 MAVIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

Query: 61 DMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

DMECHKKYGKV GFYDG+QPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI

Sbjct: 61 DMECHKKYGKVCGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREADTGKPVTLKE 174

AEDEEWKR+RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA+TGKPVTLK+

Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD 174

>CYP3A5_v1 NM_000777 human on bottom, chimp XP_519240 on top

Length = 502

Missing N-term, probably a hybrid assembly top part does not match

42 differences

Score = 756 bits (1953), Expect = 0.0

Identities = 377/426 (88%), Positives = 398/426 (93%), Gaps = 4/426 (0%)

Query: 19 YDGLQPVLAITDPDMIKTVLVKECYSVFTNRRPLGPVGFMKSAISRAEDEEWKRIRSLLS 78

Y+G PVLAITDPD+I+TVLVKECYSVFTNRR LGPVGFMKSAIS AEDEEWKRIRSLLS

Sbjct: 75 YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLS 134

Query: 79 PTFTSGKLKEMVPIIAQYGDVLVRNMRREADTGMPVTLKDVFGAYSMDVITSTSFGVNID 138

PTFTSGKLKEM PIIAQYGDVLVRN+RREA+ G PVTLKD+FGAYSMDVIT TSFGVNID

Sbjct: 135 PTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNID 194

Query: 139 SLNNPQDPFVENTKKLLRFNSLDPFILSIKIFPFLTPILEALNITVFPRKVTSFLTKSVK 198

SLNNPQDPFVE+TKK L+F LDP LSI +FPFLTP+ EALN+++FP+ +FL+KSV

Sbjct: 195 SLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVN 254

Query: 199 RIKEGRLKETQKHRVDFLQLMIDSQNSKDMESHKGFCKTLSDLELAAQSIIFIFAGYETT 258

R+K+ RL + QKHR+DFLQLMIDSQNSK+ ESHK LSDLELAAQSIIFIFAGYETT

Sbjct: 255 RMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA----LSDLELAAQSIIFIFAGYETT 310

Query: 259 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 318

SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA

Sbjct: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370

Query: 319 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 378

IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI

Sbjct: 371 IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYI 430

Query: 379 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 438

YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL

Sbjct: 431 YTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVL 490

Query: 439 KVDSRD 444

KVDSRD

Sbjct: 491 KVDSRD 496

Top part is more like 3A7 see below

CYP3A7 NM_000765

Length = 503

17 differences, might be a chimp specific CYP3 seq, not in humans

Score = 391 bits (1005), Expect = e-112

Identities = 197/219 (89%), Positives = 206/219 (94%)

Query: 14 KKGSFYDGLQPVLAITDPDMIKTVLVKECYSVFTNRRPLGPVGFMKSAISRAEDEEWKRI 73

K YD QP+LAITDPDMIKTVLVKECYSVFTNRRP GPVGFMK+AIS AEDEEWKRI

Sbjct: 70 KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRI 129

Query: 74 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNMRREADTGMPVTLKDVFGAYSMDVITSTSF 133

RSLLSPTFTSGKLKEMVPIIAQYGDVLVRN+RREA+TG PVTLK VFGAYSMDVITSTSF

Sbjct: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSF 189

Query: 134 GVNIDSLNNPQDPFVENTKKLLRFNSLDPFILSIKIFPFLTPILEALNITVFPRKVTSFL 193

GV+IDSLNNPQDPFVENTKKLLRFN LDPF+LSIK+FPFLTPILEALNITVFPRKV SFL

Sbjct: 190 GVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFL 249

Query: 194 TKSVKRIKEGRLKETQKHRVDFLQLMIDSQNSKDMESHK 232

TKSVK+IKEGRLKETQKHRVDFLQLMIDSQNSKD E+HK

Sbjct: 250 TKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHK 288

>CYP3A7 NM_000765 human on bottom chimp XP_519242 on top

Length = 503

N-term only 100%

Score = 114 bits (285), Expect = 7e-29

Identities = 55/55 (100%), Positives = 55/55 (100%)

Query: 1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK 55

MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK

Sbjct: 1 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRK 55

>CYP3A7 NM_000765 human on bottom, chimp XP_519241 on top

Length = 503

Partial seq, only 2 aa diffs

Score = 104 bits (260), Expect = 3e-25

Identities = 49/50 (98%), Positives = 50/50 (100%)

Query: 80 IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED 129

IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK+AISIAED

Sbjct: 74 IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAED 123

Score = 254 bits (649), Expect = 2e-70

Identities = 131/142 (92%), Positives = 135/142 (95%)

Query: 151 EVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSED 210

+VFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNS+D

Sbjct: 224 KVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKD 283

Query: 211 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 270

SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA

Sbjct: 284 SETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA 343

Query: 271 PPTYDTVLQLESTNMELGSVKR 292

PPTYDTVLQLE +M + R

Sbjct: 344 PPTYDTVLQLEYLDMVVNETLR 365

>CYP3A43 AC011904 human on bottom, chimp XP_527830 on top

Length = 504

Score = 811 bits (2094), Expect = 0.0

Identities = 407/425 (95%), Positives = 410/425 (96%), Gaps = 9/425 (2%)

4 amino acid differences and a difference at an intron boundary

Missing the C-terminal

Query: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF

Sbjct: 1 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61 DRECNEKYGEMWELYEGQQPMLVIMDPDMIKTVLVKECYSVFTNRLPLGPMGFLKSALSF 120

DRECNEKYGEMW LYEGQQPMLVIMDPDMIKTVLVKECYSVFTN++PLGPMGFLKSALSF

Sbjct: 61 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLK-DFFGAY 179

AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLK DFFGAY

Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKEDFFGAY 180

Query: 180 TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI--------FFEALNIG 231

TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI FEALNIG

Sbjct: 181 TMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIG 240

Query: 232 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 291

LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS

Sbjct: 241 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 300

Query: 292 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 351

IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV

Sbjct: 301 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMV 360

Query: 352 VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 410

VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER

Sbjct: 361 VNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 419

>CYP4A11 NM_000778 12 exons human on bottom, chimp XP_524697 on top

Length = 519

Assembly defects, only 3 aa diffs

Query: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60

MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF

Sbjct: 1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60

Query: 61 GHIQEPYVGLMADSVRVMLDKWEELLGQDSP 91

GHIQE L D + KW E P

Sbjct: 61 GHIQE----LQQDQELQRIQKWVETFPSACP 87

Score = 562 bits (1449), Expect = e-163

Identities = 289/365 (79%), Positives = 297/365 (81%), Gaps = 40/365 (10%)

Query: 29 LLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEPYVGLMADSVRVMLDKWEELLGQ 88

LLL+ + HR+ L P H+ I +PYVGLMADSVRVMLDKWEELLGQ

Sbjct: 131 LLLLNGQTWFQHRRMLT--------PAFHY---DILKPYVGLMADSVRVMLDKWEELLGQ 179

Query: 89 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 148

DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN

Sbjct: 180 DSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQN 239

Query: 149 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK 208

DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK

Sbjct: 240 DTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK 299

Query: 209 VSMCRRGLSLCPEVQSKRQALHFHHGLPRWRMGASCQTRTSVLRWTRFMFEGHDTTASGI 268

+ G+ + FMFEGHDTTASGI

Sbjct: 300 MEN-----------------------------GSILSDKDLRAEVDTFMFEGHDTTASGI 330

Query: 269 SWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 328

SWILYALATHPKHQERCREEIH LLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG

Sbjct: 331 SWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIG 390

Query: 329 RELSTPVTFPDGRSLPKGIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF 388

RELSTPVTFPDGRSLPKGIMV LSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF

Sbjct: 391 RELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF 450

Query: 389 SGGSR 393

SGGSR

Sbjct: 451 SGGSR 455

>CYP4A11 NM_000778 12 exons human on bottom, chimp XP_513388 on top

Length = 519

Continuation of 4A11 or, it might be 4A22, C-term only

Score = 454 bits (1167), Expect = e-130

Identities = 217/220 (98%), Positives = 218/220 (99%)

Query: 1 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGA 60

MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGA

Sbjct: 300 MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGA 359

Query: 61 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVFLSIYGLH 120

SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMV LSIYGLH

Sbjct: 360 SITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLH 419

Query: 121 HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE 180

HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE

Sbjct: 420 HNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFE 479

Query: 181 LLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 220

LLPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL

Sbjct: 480 LLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519

>CYP4B1 NM_000779 human on bottom, chimp XP_513140 on top

Length = 511

Missing N-term only 4 aa diffs

Score = 633 bits (1632), Expect = 0.0

Identities = 317/363 (87%), Positives = 318/363 (87%), Gaps = 15/363 (4%)

Query: 1 MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ 60

MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ

Sbjct: 164 MLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQ 223

Query: 61 QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVQKKIQNRRHL 120

QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKV+KKIQNRRHL

Sbjct: 224 QRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHL 283

Query: 121 DFLDILLGAWDEDDIKLSDADLRAEVDTFMFERHDTTTSGISWFLYCMXXXXXXXXXXXX 180

DFLDILLGA DEDDIKLSDADLRAEVDTFMFE HDTTTSGISWFLYCM

Sbjct: 284 DFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCM------------ 331

Query: 181 XXXXXXXXXXXXXXXXXXXXXXGPGLLPVDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 240

DDLGKMTYLTMCIKESFRLYPPVPQVYRQLS

Sbjct: 332 ---ALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLS 388

Query: 241 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDPLRFSTENASKRHPFAFMPFSA 300

KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFD LRFSTENASKRHPFAFMPFSA

Sbjct: 389 KPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSA 448

Query: 301 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLCSKNGFHLHLKPLGPG 360

GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVL SKNGFHLHLKPLGPG

Sbjct: 449 GPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPG 508

Query: 361 SGK 363

SGK

Sbjct: 509 SGK 511

>CYP4F2 NM_001082 revised exon 2 and C-terminal

Length = 520

Human on bottom chimp from XP_512460 on top

Score = 809 bits (2090), Expect = 0.0

Identities = 394/407 (96%), Positives = 399/407 (98%)

Missing N-term 113 aa. 12 aa diffs in first part, missassembled from

Two genes, 4F11 and 4F2.

Query: 2 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 61

SAA+APKD FY FL+PWLGDGLLLS GDKWSRHRRMLTPAFHFNILKPYMKIFN+SVNI

Sbjct: 114 SAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNI 173

Query: 62 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSALVS 121

MH KWQ LASEGSA LDMFEHISLMTLDSLQKCVFSF+S+CQEKPSEYIAAILELSALVS

Sbjct: 174 MHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVS 233

Query: 122 KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS 181

KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS

Sbjct: 234 KRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKS 293

Query: 182 KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER 241

KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER

Sbjct: 294 KTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQER 353

Query: 242 CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV 301

CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV

Sbjct: 354 CRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV 413

Query: 302 IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF 361

IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF

Sbjct: 414 IPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTF 473

Query: 362 AMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 408

AMAEMKVVLALTLL FRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS

Sbjct: 474 AMAEMKVVLALTLLAFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS 520

>CYP4F3 NM_000896

human on bottom, chimp XP_512458 on top

partial seq, 3 aa diffs

Score = 405 bits (1042), Expect = e-116

Identities = 192/195 (98%), Positives = 193/195 (98%)

Query: 1 MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCM 60

MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA LPFLTMC+

Sbjct: 326 MFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCI 385

Query: 61 KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 120

KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF

Sbjct: 386 KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

Query: 121 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELV 180

DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLL FRVLPDHTEPRRKPELV

Sbjct: 446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELV 505

Query: 181 LRAEGGLWLRVEPLS 195

LRAEGGLWLRVEPLS

Sbjct: 506 LRAEGGLWLRVEPLS 520

>CYP4F11 N-terminal is on AC011517 rest is on AC020950

Length = 523

Score = 204 bits (518), Expect = 7e-56

Identities = 99/100 (99%), Positives = 99/100 (99%), Gaps = 1/100 (1%)

Top part of 4F2 above is really 4F11 as shown here, assembly error

Query: 2 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 61

SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFN LKPYMKIFNKSVNI

Sbjct: 114 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFN-LKPYMKIFNKSVNI 172

Query: 62 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 101

MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN

Sbjct: 173 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 212

>CYP4F9P AC004609 complement(13903-33104 region)

human on bottom, chimp XP_524145 on top

16 aa diffs

Score = 545 bits (1403), Expect = e-157

Identities = 296/453 (65%), Positives = 305/453 (67%), Gaps = 106/453 (23%)

Query: 111 PTGFKIWMNPITPIIRLCHPNIIRSVINAS------------------GDGLLVNAGDKW 152

P GFKIWMNPITPIIRLCHPNII SVINAS GDGLLVNA DKW

Sbjct: 14 PQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKDEAFYKFLKPWLGDGLLVNASDKW 73

Query: 153 SRHRQMLMLTFHFNMLKPYMKFFTDSVNIMHAKWQLLASEGSAHLDMFEHTSLMTLDSRQ 212

S HRQMLM FHFNMLKPYMKFFTDSVNIMHAKWQLLAS GSAHLDMFEHTSLMTLDS Q

Sbjct: 74 SCHRQMLMPAFHFNMLKPYMKFFTDSVNIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQ 133

Query: 213 KCVFSFDSHCQD------------------------------------GWRFRRACCLVH 236

KCVFSFDSHCQ+ GWRFRRACCLVH

Sbjct: 134 KCVFSFDSHCQEKPSQYIATILELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVH 193

Query: 237 DFTEAIIQEQRHTLTSQGVDYFHQVKAKSKTLDFIDVLLLSKDEDWKELSDEEIRAEADT 296

DFTEAIIQEQRHTLTSQGVDYFH+VKAKSKTLDF DVLLLSK

Sbjct: 194 DFTEAIIQEQRHTLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXX 253

Query: 297 FMFEGHDTTASGLSWVLYNLARHPEYQEHCWQEPENPSISPRVLGD---SLYQMNDLAQL 353

GH+TTASGLSWVLY LARHPEYQEHCWQE + ++L D + +DLAQL

Sbjct: 254 XXXXGHNTTASGLSWVLYYLARHPEYQEHCWQEVQ------KLLKDHEPKEIEXDDLAQL 307

Query: 354 PFLTMYIKDSLRLHPPVPVISRCYTRDI-------------------------------- 381

PFLTMYIKDSL LHPPVPVISRC T+DI

Sbjct: 308 PFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLFSNFETHHNPTVWLDPE 367

Query: 382 VYDPFRFDPENSKERSPLAFIPFSAGSRQGWPVSEAGMGNCIGQAFAMAEMKVVLALTLL 441

VYDPFRFDPENSKERSPLAFIPFSAGS NCIGQAFAMAEMKVVLALTLL

Sbjct: 368 VYDPFRFDPENSKERSPLAFIPFSAGS-----------XNCIGQAFAMAEMKVVLALTLL 416

Query: 442 CFHVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS 474

CF VCPDHMEPRRKPEVIMYAEGGLWLWVKPLS

Sbjct: 417 CFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS 449

>CYP4F10P human AD000685 exons 3-6 (cosmid ends in middle of exon 6) 80% to

human on bottom, chimp XP_524140 on top

Score = 492 bits (1266), Expect = e-142

Identities = 243/274 (88%), Positives = 245/274 (89%), Gaps = 16/274 (5%)

Pseudogene 16 aa diffs and retained intron, one stop codon difference

Question? Is this a full seq in chimp?

Query: 1 MSATIEPKDKVFYGFLKPWLCEDGLLLSAGDKWSCHRGMLMPAFHFNTLKPYMKIFDESVNI 62

ATI PKDKVFY FLKPWL DG LLSAGDKWSCHRGMLMPAFHFN LKPYMKIFDESVNI

Sbjct: 1 ATIAPKDKVFYSFLKPWL-GDGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNI 59

Query: 63 MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSLAA 122

MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSL A

Sbjct: 60 MHAKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQEKPSEYIASVLELSSLVA 119

Query: 123 KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFTDAVIQEQRHTLPSQGVDDFLQAKAKS 182

KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDF DA IQE+RHTLPSQGVDDFLQAKAKS

Sbjct: 120 KRNQQILLHMDFLYYLTHDGRHFHRACRLGHDFADAAIQEKRHTLPSQGVDDFLQAKAKS 179

Query: 183 KTLDFIDVLLISKDEDGKELSDEDIKAEADTFMFEGEDPSEDQDVSSQGRGYDTRTSGLS 242

KTLDFIDVLLISKDEDGKELSDEDI+ ADTFMFE GYDTRTSGLS

Sbjct: 180 KTLDFIDVLLISKDEDGKELSDEDIRV*ADTFMFE---------------GYDTRTSGLS 224

Query: 243 WVQYNLAMHPEYQERCGQEMQEFLKVCEPKEIEW 276

WVQYNLAMHPE QERCGQE QEFLKV EPKEIEW

Sbjct: 225 WVQYNLAMHPECQERCGQERQEFLKVWEPKEIEW 258

>CYP4F11 N-terminal is on AC011517 rest is on AC020950

N-term only

Human on bottom chimp XP_512461 on top

Score = 246 bits (627), Expect = 6e-68

Identities = 113/118 (95%), Positives = 113/118 (95%)

Only 2 aa diffs in this region

Query: 1 MPQLCLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

MPQL LSWLGLGPVAASPWLLLLLVG SWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF

Sbjct: 1 MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWF 60

Query: 61 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASGTRA 118

WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSAS A

Sbjct: 61 WGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVA 118

>CYP4F12 mRNA for cytochrome P450, complete cds. AB035130 bottom,

chimp XP_524141 on top

Score = 910 bits (2351), Expect = 0.0

Identities = 445/470 (94%), Positives = 453/470 (96%), Gaps = 4/470 (0%)

13 amino acid differences and the wrong N-terminal in the automated assembly

Query: 16 PQNGTDWGSPG----PEEGLKDSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSITNAS 71

P+ WG G EEGLKDSTQMSATYSQGFT+WLGPIIPFIVLCHPDTIRSITNAS

Sbjct: 55 PKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNAS 114

Query: 72 AAIALKDDLSIRFLKPWLGDGLLLSGVDKWSRHRRMLTPAFHFNILKSYITIFNKSANIM 131

AAIA KD+L IRFLKPWLG+G+LLSG DKWSRHRRMLTPAFHFNILKSYITIFNKSANIM

Sbjct: 115 AAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIM 174

Query: 132 LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK 191

LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK

Sbjct: 175 LDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEK 234

Query: 192 RNQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFLKDKAKSK 251

R+QHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDF KDKAKSK

Sbjct: 235 RSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSK 294

Query: 252 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 311

TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC

Sbjct: 295 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 354

Query: 312 RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI 371

RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI

Sbjct: 355 RQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVI 414

Query: 372 PKGITCVINIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA 431

PKGITC+I+IIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA

Sbjct: 415 PKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFA 474

Query: 432 MAEMKVVLALMLLHFRFLPDHTEPRRKPELIMRAEGGLWLRVEHLNVGLQ 481

MAEMKVVLALMLLHFRFLPDHTEPRRK ELIMRAEGGLWLRVE LNVGLQ

Sbjct: 475 MAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVGLQ 524

>CYP4F22 AC011492 assembled gene 13 exons 114537-140651 66% to 4F3,

human on bottom, chimp XP_512456 on top

5 aa diffs

Score = 971 bits (2509), Expect = 0.0

Identities = 486/531 (91%), Positives = 489/531 (92%), Gaps = 38/531 (7%)

Query: 19 MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 78

MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP

Sbjct: 1 MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFP 60

Query: 79 QPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHNVLLVWMGPVLPLLVLVHPDYIKPLLG 138

QPPRRNWLLGHLGM PNEAGLQDEKKVLDNMH+VLLVWMGPVLPLLVLVHPDYIKPLLG

Sbjct: 61 QPPRRNWLLGHLGMVSPNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLG 120

Query: 139 ASAAIAPKDDLFYGFLKPWLGEC-------KW---------------------------- 163

ASAAIAPKDDLFYGFLKPWLG+ KW

Sbjct: 121 ASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSAD 180

Query: 164 ---AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSHNSNCQEKMSDYISAIIELSALS 220

AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFS+NSNCQEKMSDYISAIIELSALS

Sbjct: 181 IMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEKMSDYISAIIELSALS 240

Query: 221 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRWALRQQGAEAWLKAKQG 280

VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERR ALRQQGAEAWLKAKQG

Sbjct: 241 VRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRRALRQQGAEAWLKAKQG 300

Query: 281 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 340

KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK

Sbjct: 301 KTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNLAKYPEYQEK 360

Query: 341 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 400

CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI

Sbjct: 361 CREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRI 420

Query: 401 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 460

IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF

Sbjct: 421 IPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSF 480

Query: 461 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 511

AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA

Sbjct: 481 AMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA 531

>CYP4V2 formerly CYP4AH1 AC012525 Homo sapiens chromosome 4

human on bottom, chimp XP_517565 on top

Assembly errors and 4 aa diffs

Score = 192 bits (487), Expect = 4e-51

Identities = 105/150 (70%), Positives = 107/150 (71%), Gaps = 41/150 (27%)

Query: 113 MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVATYARKWQQMRPIPTVARAYPLV 172

MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVA+YARKWQQMRPIPTVARAYPLV

Sbjct: 1 MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60

Query: 173 GHALLMKPDGRAQEGYFQTPALGLFPPHHCSALKALPFPPALAWEALGTEAPWEHKAIIE 232

GHALLMKPDGR +FQ IIE

Sbjct: 61 GHALLMKPDGRE---FFQ--------------------------------------QIIE 79

Query: 233 YTEEYRHMPLLKLWVGPVPMVALYNAENVE 262

YTEEYRHMPLLKLWVGPVPMVALYNAENVE

Sbjct: 80 YTEEYRHMPLLKLWVGPVPMVALYNAENVE 109

Score = 78.2 bits (191), Expect = 9e-17

Identities = 36/44 (81%), Positives = 38/44 (86%)

Query: 369 GWRTHTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANTLISSV 412

G T TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQAN L+ +

Sbjct: 134 GLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177

Score = 621 bits (1601), Expect = e-180

Identities = 316/365 (86%), Positives = 319/365 (87%), Gaps = 43/365 (11%)

Query: 501 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKIL 560

ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSL+IL

Sbjct: 202 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQIL 261

Query: 561 HTFTNSGASKSKQKHVIIIQIIQVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 620

HTFTNS VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL

Sbjct: 262 HTFTNS-----------------VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304

Query: 621 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 680

SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV

Sbjct: 305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV-- 362

Query: 681 MFGPFTGYIVHPPGLDTYLLSSGKSDRPATVEDLKKFRYLECVIKETLRLFPSVPLFARS 740

KSDRPATVEDLKK RYLECVIKETLRLFPSVPLFARS

Sbjct: 363 -----------------------KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARS 399

Query: 741 VSEDCEV-AGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPKNAQGRHPYAYVPF 799

VSED + AGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFP+NAQGRHPYAYVPF

Sbjct: 400 VSEDYFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPF 459

Query: 800 SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 859

SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR

Sbjct: 460 SAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 519

Query: 860 NADER 864

NADER

Sbjct: 520 NADER 524

>CYP4X1 R56515, R53456, AA652746, AC026935

human on bottom, chimp XP_513386 on top

missing C-helix, Only 2 aa diffs

Score = 993 bits (2568), Expect = 0.0

Identities = 486/506 (96%), Positives = 487/506 (96%), Gaps = 18/506 (3%)

Query: 1 MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF

Sbjct: 1 MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKF 60

Query: 61 IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFF IYDPDYAKTLLSRTDPKSQYLQKFSPPL

Sbjct: 61 IQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPL 120

Query: 121 LG------------------TPGFHFNILKAYVEVMAHSVKMMLDKWEKICSTQDTSVEV 162

LG TPGFHFNILKAY+EVMAHSVKMMLDKWEKICSTQDTSVEV

Sbjct: 121 LGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEV 180

Query: 163 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 222

YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL

Sbjct: 181 YEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKL 240

Query: 223 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 282

SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS

Sbjct: 241 SPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSS 300

Query: 283 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 342

FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ

Sbjct: 301 FSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQ 360

Query: 343 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 402

LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW

Sbjct: 361 LGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVW 420

Query: 403 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 462

KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD

Sbjct: 421 KNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPD 480

Query: 463 PTRPLTFPNHFILKPKNGMYLHLKKL 488

PTRPLTFPNHFILKPKNGMYLHLKKL

Sbjct: 481 PTRPLTFPNHFILKPKNGMYLHLKKL 506

>4Z2P AL731892.5 94% to 4Z1 1 stop codon in exon 8

human on bottom, chimp XP_513139 on bottom

might be 4Z1, hard to tell the two apart

16 aa diffs

Score = 222 bits (566), Expect = 2e-60

Identities = 108/138 (78%), Positives = 113/138 (81%), Gaps = 2/138 (1%)

Query: 47 EPSWLRELMAQPFLLMILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPVHWFYGHKEFY 106

EPSWL+ELMA PFLL+ILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPP HWFYGHKE Y

Sbjct: 2 EPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPAHWFYGHKEXY 61

Query: 107 PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQGLSYIRSN--LWSRQ 164

PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQ S+ L S

Sbjct: 62 PVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESWV 121

Score = 369 bits (948), Expect = e-104

Identities = 183/211 (86%), Positives = 186/211 (88%), Gaps = 17/211 (8%)

Query: 408 ENTKDFSEADLQAEVKTFMFAGHDTTSSAIFWIFYCLAKYPEHQQRCRDEIRELLGDGSS 467

ENTKDFSEADLQAEVKTFMFAGHDTT++AI WIFYCLAKYPEHQQRC DEIRELLGDGSS

Sbjct: 294 ENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSS 353

Query: 468 ITWEHLSQMPYTTMCIKECLRLYAPVVNIS-----------------GITVFINIWALHH 510

ITWEHLSQMPY TMCIKECLRLYAPVVNIS GITVFINIWALHH

Sbjct: 354 ITWEHLSQMPYATMCIKECLRLYAPVVNISQLLDKPITFPDGRSLPAGITVFINIWALHH 413

Query: 511 NPCFWEDPQVFNPLRFSRESSEKMHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRF 570

NP FWE+PQVFNPLRFSRESSEKMHPYAFIPFSAG RNCIGQHFAII CKVAVALTLL F

Sbjct: 414 NPYFWENPQVFNPLRFSRESSEKMHPYAFIPFSAGPRNCIGQHFAIIGCKVAVALTLLCF 473

Query: 571 ELAPDYSRPSQPVRQMLLKSKNGIHVFAKKV 601

ELAPDYSRP QPVRQMLLKSKNGIHVFAKKV

Sbjct: 474 ELAPDYSRPPQPVRQMLLKSKNGIHVFAKKV 504

>CYP5A1 NM_001061 this gene is 197000 bases long

human on bottom, chimp XP_519420 on top

Assembly errors, 6 aa diffs

Score = 243 bits (620), Expect = 2e-66

Identities = 119/119 (100%), Positives = 119/119 (100%)

Query: 97 YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI 156

YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI

Sbjct: 32 YSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVI 91

Query: 157 SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN 215

SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN

Sbjct: 92 SEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLN 150

Score = 166 bits (420), Expect = 3e-43

Identities = 77/79 (97%), Positives = 78/79 (98%)

Query: 314 MVPLISQACNLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFV 373

MVPLISQAC+LLLAHLKRYAESGDAFDIQRCYCNYTTDVVASV FGTPVDSWQAPEDPFV

Sbjct: 152 MVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPEDPFV 211

Query: 374 KHCKRFFEFCIPRPILVLL 392

KHCKRFFEFCIPRPILVLL

Sbjct: 212 KHCKRFFEFCIPRPILVLL 230

Score = 89.4 bits (220), Expect = 4e-20

Identities = 44/45 (97%), Positives = 45/45 (100%)

Query: 521 VLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 565

+LSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE

Sbjct: 230 LLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 274

Score = 527 bits (1357), Expect = e-152

Identities = 258/277 (93%), Positives = 264/277 (95%)

Query: 624 KAAPKTVSLVQASTQAQRRRDFLQMVLDARHSASPMGVQDFDIVREVFSSTGCKPNPSRQ 683

K ++L +RRRDFLQMVLDARHSASPMGVQDFDIVR+VFSSTGCKPNPSRQ

Sbjct: 258 KLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQ 317

Query: 684 HQPSSMARPLTVDEIVGQAFIFLIAGYEIVTNTLSFATYLLATNPDCQEKLLREVDVFKE 743

HQPS MARPLTVDEIVGQAFIFLIAGYEI+TNTLSFATYLLATNPDCQEKLLREVDVFKE

Sbjct: 318 HQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKE 377

Query: 744 KHMAPEFCSLKEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG 803

KHMAPEFCSL+EGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG

Sbjct: 378 KHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVG 437

Query: 804 ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV 863

ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV

Sbjct: 438 ALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHV 497

Query: 864 LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 900

LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR

Sbjct: 498 LHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534

>CYP7A1 NM_000780 human on bottom, chimp XP_519773 on top

Length = 504

Only 3 aa diffs

Score = 979 bits (2531), Expect = 0.0

Identities = 482/504 (95%), Positives = 485/504 (96%), Gaps = 18/504 (3%)

Query: 1 MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60

MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ

Sbjct: 1 MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ 60

Query: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120

RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN

Sbjct: 61 RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN 120

Query: 121 TT------------------VTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 162

TT +TESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF

Sbjct: 121 TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF 180

Query: 163 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 222

EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE

Sbjct: 181 EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE 240

Query: 223 SLRHENLQKRESVSELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 282

SLRHENLQKRES+SELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ

Sbjct: 241 SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ 300

Query: 283 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS 342

MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL+SIIKESLRLSSAS

Sbjct: 301 MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLNSIIKESLRLSSAS 360

Query: 343 LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 402

LNIRTAKEDFTLHLEDGSYNIRKD IIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK

Sbjct: 361 LNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK 420

Query: 403 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 462

TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD

Sbjct: 421 TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD 480

Query: 463 QSRAGLGILPPLNDIEFKYKFKHL 486

QSRAGLGILPPLNDIEFKYKFKHL

Sbjct: 481 QSRAGLGILPPLNDIEFKYKFKHL 504

>CYP8A1 D83402 human on bottom, chimp XP_514713 on top

Length = 500

Partial seq, 11 aa diffs

Score = 900 bits (2326), Expect = 0.0

Identities = 449/478 (93%), Positives = 452/478 (94%), Gaps = 16/478 (3%)

Query: 27 QSRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYITVLLDPHS 86

++RRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRY+TVLLDPHS

Sbjct: 23 RTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHS 82

Query: 87 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYT 146

YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMK TLLHRELQALTEAMYT

Sbjct: 83 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 142

Query: 147 NLHTVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 206

NLH VLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD

Sbjct: 143 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSAD 202

Query: 207 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLH 266

VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLA RAHRSKWLESYLLH

Sbjct: 203 VFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLH 262

Query: 267 LEEMGVSEEMQARALVLQLWATQ----------------NPEPLAAFRGELESILWQAEQ 310

LEEMGVSEEMQARALVLQLWATQ NPE LAA RGELESILWQAEQ

Sbjct: 263 LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQ 322

Query: 311 PVLQTPILPQKVLASTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 370

PV QT LPQKVL STPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR

Sbjct: 323 PVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDR 382

Query: 371 LLLFPFLSPQRDPEIYADPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 430

LLLFPFLSPQRDPEIY DPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL

Sbjct: 383 LLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCL 442

Query: 431 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 488

GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

Sbjct: 443 GRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP 500

>CYP11B2 NM_000498 human on bottom, chimp XP_519994 on top

Length = 503

Partial seq, only 2 aa diffs

Score = 592 bits (1526), Expect = e-171

Identities = 295/336 (87%), Positives = 303/336 (90%)

Query: 367 RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM 426

RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM

Sbjct: 33 RTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVM 92

Query: 427 LPEDVEKLQQVDSLHPRRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 486

LPEDVEKLQQVDSLHP RMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK

Sbjct: 93 LPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPK 152

Query: 487 AVQRFLPMVDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 546

AVQRFLPMVDAVARDFSQAL+KKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV

Sbjct: 153 AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLV 212

Query: 547 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 606

GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ

Sbjct: 213 GHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQ 272

Query: 607 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTVRPATSPTQRGWLG 666

KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDT T

Sbjct: 273 KIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELAR 332

>CYP17 NM_000102 human on bottom, chimp NP_001009052, Q8HYN1 AAN86251 on top

Length = 508

2 aa diffs

Score = 1023 bits (2644), Expect = 0.0

Identities = 506/508 (99%), Positives = 508/508 (100%)

Query: 1 MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60

MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY

Sbjct: 1 MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60

Query: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120

GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH

Sbjct: 61 GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120

Query: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180

WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS

Sbjct: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180

Query: 181 LICFNTSYKNGDPELNIIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240

LICFNTSYKNGDPELN+IQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN

Sbjct: 181 LICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRN 240

Query: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF

Sbjct: 241 DLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF 300

Query: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV

Sbjct: 301 GAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV 360

Query: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTQVIINLWALHHNEKEWHQPDQFMPERFLNP 420

LRLRPVAPMLIPHKANVDSSIGEFAVDKGT+VIINLWALHHNEKEWHQPDQFMPERFLNP

Sbjct: 361 LRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNP 420

Query: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP

Sbjct: 421 AGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIP 480

Query: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508

KVVFLIDSFKVKIKVRQAWREAQAEGST

Sbjct: 481 KVVFLIDSFKVKIKVRQAWREAQAEGST 508

>CYP19 NM_000103 human on bottom, chimp XP_510404 on top

Length = 503

Only 2 aa diffs

Score = 823 bits (2125), Expect = 0.0

Identities = 423/503 (84%), Positives = 429/503 (85%), Gaps = 59/503 (11%)

Query: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60

MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI

Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60

Query: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120

SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL

Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120

Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKESA-----------------------IVVK 157

GLQCIGMHEKGIIFNNNPELWKTTRPFFMK + V

Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180

Query: 158 IQGYFDAW----------------------QALLIKPDIFF--------------KISWL 181

GY D A+++K +F KISWL

Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240

Query: 182 YKKYEKSVKDLKDAMEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 241

YKKYEKSVKDLKDA+EVLIAEKR RISTEEKLEECMDFATELILAEKRGDLTRENVNQCI

Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300

Query: 242 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 301

LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI

Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360

Query: 302 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 361

YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK

Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420

Query: 362 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 421

NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH

Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480

Query: 422 PDETKNMLEMIFTPRNSDRCLEH 444

PDETKNMLEMIFTPRNSDRCLEH

Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503

>CYP20 AC011737.8 chr 2 (missing exons 12,13) AC080075.2 (missing exons

1,7,8), human on bottom, chimp XP_516042 on top

assembly errors but only 2 aa diffs

Score = 404 bits (1039), Expect = e-115

Identities = 207/226 (91%), Positives = 211/226 (93%), Gaps = 3/226 (1%)

Query: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60

MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN

Sbjct: 1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVN 60

Query: 61 LHEKYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120

LHE+YGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN

Sbjct: 61 LHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSGGGSVSEN 120

Query: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180

HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV

Sbjct: 121 HMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMV 180

Query: 181 MGSTFEDDQEVIRFQKNHGTVMCTWAICFLTTSEE---VQKKLYEE 223

MGSTFEDDQEVIRFQKNHGTV FL S + +KK YE+

Sbjct: 181 MGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNMTRKKQYED 226

Score = 254 bits (648), Expect = 3e-70

Identities = 146/254 (57%), Positives = 164/254 (64%), Gaps = 59/254 (23%)

Query: 115 GSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMK 174

GS+ +N RKK YE+ + L+S ++K E + SQH+

Sbjct: 212 GSLDKNMTRKKQYEDALMQ-LESVLRNIIK-------------ERKGRNFSQHIF----- 252

Query: 175 SVTQMVMGSTFEDDQEVIRFQKNHGTV-------MCTWAICFLTTSEEVQKKLYEEINQV 227

+ +V G+ +DQ+++ +CTWAICFLTTSEEVQKKLYEEINQV

Sbjct: 253 -IDSLVQGNL--NDQQILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQV 309

Query: 228 FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQHQDIEGKIDQFIIPRETLVLYALG 287

FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQ QDIEGKID+FIIPRETLVLYALG

Sbjct: 310 FGNGPVTPEKIEQLRYCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRETLVLYALG 369

Query: 288 VVLQDPNTWPSPHKYEIFVIVFVTVSFCVCTFCIPFLSVEEKTQFDPDRFDDELVMKTFS 347

VVLQDPNTWPSPHK FDPDRFDDELVMKTFS

Sbjct: 370 VVLQDPNTWPSPHK------------------------------FDPDRFDDELVMKTFS 399

Query: 348 SLGFSGTQECPELR 361

SLGFSGTQECPELR

Sbjct: 400 SLGFSGTQECPELR 413

>CYP21A2 M26856 human on bottom, chimp XP_527350 on top

only 6 aa diffs

Score = 922 bits (2383), Expect = 0.0

Identities = 463/497 (93%), Positives = 467/497 (93%), Gaps = 19/497 (3%)

Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60

MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY

Sbjct: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60

Query: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYPDLSLGDYSLLWKAH 120

RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVS+NYPDLSLGDYSLLWKAH

Sbjct: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120

Query: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180

KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD

Sbjct: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180

Query: 181 KIKEDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRVSRSARSFHPLQA---------- 230

KIK+DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR + QA

Sbjct: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240

Query: 231 -------SLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGAAHVHMAVVDLLIGGTETTA 283

SLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG HVHMA VDLLIGGTETTA

Sbjct: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEG--HVHMAAVDLLIGGTETTA 298

Query: 284 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP 343

NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP

Sbjct: 299 NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP 358

Query: 344 VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR 403

VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR

Sbjct: 359 VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSR 418

Query: 404 ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ 463

ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ

Sbjct: 419 ALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQ 478

Query: 464 VRLQPRGMGAHSPGQSQ 480

VRLQPRGMGAHSPGQ+Q

Sbjct: 479 VRLQPRGMGAHSPGQNQ 495

>CYP24 NM_000782 human on bottom, chimp XP_514731 on top

Score = 717 bits (1852), Expect = 0.0

Identities = 367/410 (89%), Positives = 369/410 (90%), Gaps = 32/410 (7%)

Query: 1 MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTTGGETQNAAALPG 60

MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLT GGETQNAAALPG

Sbjct: 1 MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG 60

Query: 61 PTRWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

PT WPLL SLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR

Sbjct: 61 PTSWPLLASLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR 120

Query: 121 TESAYPQRLEIKPWKAYRDYREEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 180

TES PQRLEIKPWKAYRDYR+EGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN

Sbjct: 121 TESV-PQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN 179

Query: 181 EVCRLGPAFLGLVLADFMGRIDELC--------------------ICLVLYEKRFGLLQK 220

EV LADFMGRIDELC ICLVLYEKRFGLLQK

Sbjct: 180 EV-----------LADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQK 228

Query: 221 NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNR 280

NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQ HTLAWDTIFKSVKACIDNR

Sbjct: 229 NAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQGHTLAWDTIFKSVKACIDNR 288

Query: 281 LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSHNPQVQ 340

LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLS NPQVQ

Sbjct: 289 LEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQ 348

Query: 341 QKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSIPFTTRTLD 390

QKLLKEIQSVLPENQ PR EDLRNMPYLKACLKESMRLTP +PFTTRTLD

Sbjct: 349 QKLLKEIQSVLPENQRPREEDLRNMPYLKACLKESMRLTPGVPFTTRTLD 398

>CYP26A1 NM_000783 on bottom, chimp XP_507927 on top

Length = 497

Only one amino acid difference plus some missing seq.

Query: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM

Sbjct: 1 MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

Query: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRP 87

VLQRRKFLQMKRRKYGFIYKTHLFGRP

Sbjct: 61 VLQRRKFLQMKRRKYGFIYKTHLFGRP 87

Missing sequence 88-145 in this automated assembly

Score = 718 bits (1853), Expect = 0.0

Identities = 351/354 (99%), Positives = 352/354 (99%)

Query: 89 YGREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD 148

+ REALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD

Sbjct: 144 FSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGD 203

Query: 149 GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRTSEA 208

GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLR SEA

Sbjct: 204 GDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEA 263

Query: 209 GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL 268

GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL

Sbjct: 264 GQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVL 323

Query: 269 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 328

QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL

Sbjct: 324 QKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFEL 383

Query: 329 NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV 388

NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV

Sbjct: 384 NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCV 443

Query: 389 GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI 442

GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI

Sbjct: 444 GKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI 497

>CYP26C1 AL358613.11 May 2, 2001 522 amino acids, 6 exons,

human on bottom, chimp XP_521563 on top

no diffs in aligned region

Score = 333 bits (855), Expect = 7e-94

Identities = 168/168 (100%), Positives = 168/168 (100%)

Query: 458 QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS 517

QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS

Sbjct: 68 QGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS 127

Query: 518 HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA 577

HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA

Sbjct: 128 HTLLGAVGEPHRRRRKVLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKA 187

Query: 578 LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK 625

LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK

Sbjct: 188 LTFRMAARILLGLRLDEAQCATLARTFEQLVENLFSLPLDVPFSGLRK 235

Score = 148 bits (374), Expect = 4e-38

Identities = 69/70 (98%), Positives = 69/70 (98%)

Query: 282 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 341

MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG

Sbjct: 1 MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFG 60

Query: 342 ETLHWLVQVS 351

ETLHWLVQ S

Sbjct: 61 ETLHWLVQGS 70

>CYP27B1 NM_000785 human on bottom, chimp XP_509175 on top

Length = 508

Only 2 aa diffs

Score = 988 bits (2554), Expect = 0.0

Identities = 506/587 (86%), Positives = 506/587 (86%), Gaps = 79/587 (13%)

Query: 225 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 284

MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR

Sbjct: 1 MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPSTPSFLAELFCKGGLSR 60

Query: 285 LHELQPERTDAHEIRKRRVEAGGGMATLGQSPSGLLAEGAALRCGDPADIVQVQGAARFG 344

LHELQ VQGAA FG

Sbjct: 61 LHELQ-----------------------------------------------VQGAAHFG 73

Query: 345 PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE 404

PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE

Sbjct: 74 PVWLASFGTVRTVYVAAPALVEELLRQEGPRPERCSFSPWTEHRRCRQRACGLLTAEGEE 133

Query: 405 WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF 464

WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF

Sbjct: 134 WQRLRSLLAPLLLRPQAAARYAGTLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKF 193

Query: 465 GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL 524

GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL

Sbjct: 194 GLEGIAAVLLGSRLGCLEAQVPPDTETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRL 253

Query: 525 CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE 584

CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE

Sbjct: 254 CRDWDQMFAFAQRHVERREAEAAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTE 313

Query: 585 LLLAGVDTVRFSLRAVSRFQGLASADSGAIFLLQAIHYGHVSNTLSWALYELSRHPEVQT 644

LLLAGVDT VSNTLSWALYELSRHPEVQT

Sbjct: 314 LLLAGVDT--------------------------------VSNTLSWALYELSRHPEVQT 341

Query: 645 ALHSEITAALSPGSSAYPPATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI 704

ALHSEITAALSPGSSAYP ATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI

Sbjct: 342 ALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYI 401

Query: 705 IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA 764

IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA

Sbjct: 402 IPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLA 461

Query: 765 ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 811

ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR

Sbjct: 462 ELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR 508

>CYP27C1 AC027142 43% identical to 27A1 assembled gene

human on bottom, chimp XP_525906 on top

3 aa diffs

Score = 913 bits (2359), Expect = 0.0

Identities = 466/522 (89%), Positives = 466/522 (89%), Gaps = 53/522 (10%)

Query: 1 MPGPRTLANLAEFFCRDGSSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR 60

MPGPRTLANLAEFFCRDG SRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR

Sbjct: 74 MPGPRTLANLAEFFCRDGFSRIHEIQQKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLR 133

Query: 61 AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN 120

AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN

Sbjct: 134 AEGAAPQRANMESWREYRDLRGRATGLISAEGEQWLKMRSVLRQRILKPKDVAIYSGEVN 193

Query: 121 QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE 180

QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE

Sbjct: 194 QVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVE 253

Query: 181 YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY 240

YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY

Sbjct: 254 YIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQY 313

Query: 241 QMDRGRRVSGGLLTYLFLSQALTLPEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ 300

QMDRGRRVSGGLLTYLFLSQALTL EIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ

Sbjct: 314 QMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQ 373

Query: 301 QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI 360

QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI

Sbjct: 374 QTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLI 433

Query: 361 PKGQGSPCSLACSPGRVEVASHRWESLKGSTAFSVAAVTFGVQCGVGREGAAAILGTQLA 420

PK GTQLA

Sbjct: 434 PK-----------------------------------------------------GTQLA 440

Query: 421 LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL 480

LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL

Sbjct: 441 LCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHL 500

Query: 481 VVIQLLQHFEIKTSSQTKAVHAKTHGLLTPGGPIHVRFVNRK 522

VVIQLLQHFEIKTSSQT AVHAKTHGLLTPGGPIHVRFVNRK

Sbjct: 501 VVIQLLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK 542

>CYP39A1 AC008104 AL035670 note heme region exon corrected 1/18/02

human on bottom, chimp XP_518518 on top

Partial seq, only 2 aa diffs

Score = 721 bits (1860), Expect = 0.0

Identities = 364/447 (81%), Positives = 369/447 (82%), Gaps = 76/447 (17%)

Query: 35 RKNLRRPPCVKGWIPWIGVGFEFGKAPLEFIEKARIKF---------------------- 72

RKNLRRPPC+KGWIPWIGVGFEFGKAPLEFIEKARIK+

Sbjct: 23 RKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGI 82

Query: 73 SLFI------------------ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE 114

++F+ ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE

Sbjct: 83 NVFLKSKKVDFELAVQNIVYRTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEE 142

Query: 115 LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQAYDEDFE 174

LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQ YDEDFE

Sbjct: 143 LHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFE 202

Query: 175 YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM------------------ 216

YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSM

Sbjct: 203 YGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKSAKDNSMTLLQATLDIVETETSKEN 262

Query: 217 ------------------VAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL 258

VAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL

Sbjct: 263 SPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIHKAIMEGISSVFGKAGKDKIKVSEDDL 322

Query: 259 EKLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP 318

E LLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP

Sbjct: 323 ENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEP 382

Query: 319 ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 378

ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP

Sbjct: 383 ELFKPERWKKANLEKHSFLDCFMAFGSGKFQCPARWFALLEVQMCIILILYKYDCSLLDP 442

Query: 379 LPKQSYLHLVGVPQPEGQCRIEYKQRI 405

LPKQSYLHLVGVPQPEGQCRIEYKQRI

Sbjct: 443 LPKQSYLHLVGVPQPEGQCRIEYKQRI 469

>CYP46 NM_006668 human on bottom, chimp XP_510158 on top

Length = 500

100% identical in aligned regions

Score = 971 bits (2510), Expect = 0.0

Identities = 500/567 (88%), Positives = 500/567 (88%), Gaps = 67/567 (11%)

Query: 1 MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL

Sbjct: 1 MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL 60

Query: 61 QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120

QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL

Sbjct: 61 QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL 120

Query: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180

FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM

Sbjct: 121 FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM 180

Query: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240

QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL

Sbjct: 181 QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL 240

Query: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300

REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF

Sbjct: 241 REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF 300

Query: 301 IAGIPSLRIRGEACIRLAQKEMLSSFIHLLIRYFLNMVLHLEDSSSPVSHETSANHLAFT 360

IAG HETSANHLAFT

Sbjct: 301 IAG----------------------------------------------HETSANHLAFT 314

Query: 361 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 420

VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL

Sbjct: 315 VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLL 374

Query: 421 EEETLIDGVRVPGNTPLLWLKRCQGNNLGTRDERTLCPQFSTYVMGRMDTYFEDPLTFNP 480

EEETLIDGVRVPGNTPLL FSTYVMGRMDTYFEDPLTFNP

Sbjct: 375 EEETLIDGVRVPGNTPLL---------------------FSTYVMGRMDTYFEDPLTFNP 413

Query: 481 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 540

DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ

Sbjct: 414 DRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQ 473

Query: 541 ATLKPLDPVLCTLRPRGWQPAPPPPPC 567

ATLKPLDPVLCTLRPRGWQPAPPPPPC

Sbjct: 474 ATLKPLDPVLCTLRPRGWQPAPPPPPC 500

>CYP51 NM_000786 human on bottom, chimp XP_509606 on top

Length = 509

Partial seq

Score = 235 bits (600), Expect = 3e-65

Identities = 111/114 (97%), Positives = 111/114 (97%)

Query: 8 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVVGYT 67

KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV GYT

Sbjct: 341 KKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYT 400

Query: 68 IPPGHQVCVSPTVNQRLKDSWVERLDFNPDCYLQDNPASGEKFAYVPFGAGCHR 121

IPPGHQVCVSPTVNQRLKDSWVERLDFNPD YLQDNPASGEKFAYVPFGAG HR

Sbjct: 401 IPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHR 454

>CYP51 NM_000786 human on bottom, chimp XP_519193 on top

Length = 509

Score = 910 bits (2353), Expect = 0.0

Identities = 444/446 (99%), Positives = 446/446 (100%)

Query: 179 VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 238

VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL

Sbjct: 64 VKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALL 123

Query: 239 FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK 298

FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK

Sbjct: 124 FNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEK 183

Query: 299 ETKEYFQSWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA 358

ETKEYF+SWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA

Sbjct: 184 ETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHA 243

Query: 359 AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT 418

AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT

Sbjct: 244 AWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLT 303

Query: 419 DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQL 478

DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ+KCYLEQKTVCGENLPPLTYDQL

Sbjct: 304 DDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQL 363

Query: 479 KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE 538

KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE

Sbjct: 364 KDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVE 423

Query: 539 RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 598

RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG

Sbjct: 424 RLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDG 483

Query: 599 YFPTVNYTTMIHTPENPVIRYKRRSK 624

YFPTVNYTTMIHTPENPVIRYKRRSK

Sbjct: 484 YFPTVNYTTMIHTPENPVIRYKRRSK 509

>CYP51P1 processed pseudogene U36926 5 in frame stops

human on bottom, chimp XP_516594 on top

Score = 536 bits (1380), Expect = e-155

Identities = 273/303 (90%), Positives = 278/303 (91%), Gaps = 18/303 (5%)

Query: 1 MEEVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSPIPFLGHAIAF 60

MEEV GGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSP+PFLGHAIAF

Sbjct: 24 MEEVAGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLTAGAKSPPYIFSPVPFLGHAIAF 83

Query: 61 GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP 120

GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP

Sbjct: 84 GKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAAALLFNSKNEVLNAEDVYSRLTTP 143

Query: 121 VFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKKHVSIIEKETKEYFESWGESGE------ 174

VFG GVAYDVPNPVFLEQKK LKSGLNIAHFK HVSIIEKETKEYFESWGESGE

Sbjct: 144 VFG*GVAYDVPNPVFLEQKKTLKSGLNIAHFK*HVSIIEKETKEYFESWGESGEKNVFAA 203

Query: 175 ------------MHGKEIRSQPNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAH 222

+HGKEIRSQ NEKVAQLYADLDGGFSHAAWLLPGWLPLP FRRRDRAH

Sbjct: 204 LSELIILTASHYLHGKEIRSQ