62
sequences April 5, 2006
D.
Nelson
>CYP1A1
NM_000499 human on bottom, chimp XP_510670 on top
Length = 512
Score = 560 bits (1442), Expect = e-162
Identities = 274/275 (99%), Positives = 275/275 (100%)
Partial
seq, one aa diff
The
rest of this seq is on chr16_random:21929790-21932380
There
is only 1 aa diff in the whole seq
Query:
13 MLFPISMSATEFLLASVIFCLVFWVIRASRPRVPKGLKNPPGPWGWPLIGHMLTLGKNPH
72
MLFPISMSATEFLLASVIFCLVFWVIRASRP+VPKGLKNPPGPWGWPLIGHMLTLGKNPH
Sbjct:
1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPH 60
Query:
73
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 132
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS
Sbjct:
61
LALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQS 120
Query:
133 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 192
MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG
Sbjct:
121 MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAG 180
Query:
193 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 252
PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL
Sbjct:
181 PGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPIL 240
Query:
253 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 287
RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK
Sbjct:
241 RYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEK 275
>CYP1A2
NM_000761 human on bottom, chimp XP_510671 on top
Length = 515
Score = 959 bits (2480), Expect = 0.0
Identities = 475/483 (98%), Positives =
481/483 (99%), Gaps = 1/483 (0%)
8
amino acid differences, seq gap at end, missing 21 aa
Query:
1 MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
60
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
Sbjct:
1
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN 60
Query:
61
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
Sbjct:
61
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG 120
Query:
121 QSMTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAEALISRLQELM 180
QS+TFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEA+ALISRLQELM
Sbjct:
121 QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM 180
Query:
181 AGPGHFDPYNQVVMSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
240
AGPGHFDPYNQVV+SVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
Sbjct:
181 AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
240
Query:
241 ILRYLPNPALQRFKAFNQRFLRFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGG 300
ILRYLPNPALQRFKAFNQRFL FLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS G
Sbjct:
241 ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRAS-G 299
Query:
301 DLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL
360
+LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL
Sbjct:
300 NLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRL
359
Query:
361 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFINQWQVNHDPE 420
SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVF+NQWQVNHDPE
Sbjct:
360 SDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPE 419
Query:
421 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEVFLFLAILLQQL 480
LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWE+FLFLAILLQQL
Sbjct:
420 LWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQL 479
Query:
481 EFS 483
EFS
Sbjct:
480 EFS 482
>CYP1B1
NM_000104
human
on bottom, chimp XP_515417 on top
missing
C-term, 2 aa diffs
Score = 550 bits (1417), Expect = e-159
Identities = 273/275 (99%), Positives =
274/275 (99%)
Query:
1 MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLGSAPPGPFAWPLI 60
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQL SAPPGPFAWPLI
Sbjct:
1
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60
Query:
61
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSF 120
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRP+F
Sbjct:
61
GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120
Query:
121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180
ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
Sbjct:
121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180
Query:
181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240
LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
Sbjct:
181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240
Query:
241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275
VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK
Sbjct:
241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDK 275
>CYP1B1
NM_000104
human
on bottom, chimp XP_515416 on top
C-term
part, 3 aa diffs
Score = 348 bits (892), Expect = 7e-99
Identities = 169/172 (98%), Positives =
170/172 (98%)
Query:
1
MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 60
MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP
Sbjct:
372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431
Query:
61 VKWPNPENFDPARFLDKDGFINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC
120
VKWPNPENFDPARFLDKDG INKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC
Sbjct:
432 VKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC
491
Query:
121 NFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQKLQAKETCQ 172
+FRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQ LQAKETCQ
Sbjct:
492 DFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ 543
>CYP2A7v1
wild type AC008537.3 Exon 8 is different from U22029
Length = 494
Human
on bottom, chimp XP_524272 on top
Only
2 aa diffs in aligned region
Score = 206 bits (523), Expect = 4e-56
Identities = 105/116 (90%), Positives =
106/116 (91%), Gaps = 9/116 (7%)
Query:
36
QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQE 95
QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQ
Sbjct:
218 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ- 276
Query:
96 VHPSSQCGEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE
151
EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE
Sbjct:
277 --------EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE
324
>CYP2A13 U22028 human on bottom, chimp
XP_512681 on top
partial
seq, one aa diff
Score = 380 (133.8 bits), Expect =
1.1e-66, Sum P(2) = 1.1e-66
Identities = 73/73 (100%), Positives =
73/73 (100%)
Query: 227
GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 286
GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR
Sbjct: 302
GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQR 361
Query: 287 FGDMLPMGLAHRV 299
FGDMLPMGLAHRV
Sbjct: 362 FGDMLPMGLAHRV 374
Score = 263 (92.6 bits), Expect =
1.1e-66, Sum P(2) = 1.1e-66
Identities = 56/68 (82%), Positives =
57/68 (83%)
Query: 22
ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQVTGCSPP 81
ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLG FQFT TSTGQ+
Sbjct: 166
ANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQLYEMFSS 225
>CYP2A18PN
= CYP2A7PT U22030 and 2A7PC U22044, human on bottom,
chimp
XP_524273 on top
Length = 275
Pseudogene
with only one aa diff in aligned region
Score = 287 bits (734), Expect = 4e-80
Identities = 188/354 (53%), Positives =
207/354 (58%), Gaps = 81/354 (22%)
Query:
1
MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTESVSAMAPC 60
MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTE +
Sbjct:
1
MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTEHICDSIMK 60
Query:
61 SPFTWGPGGSWCCADMMPSRRLWWTRLRSSAGEVSRPPSTGSSKAVLLFFSVFLLCPLTS
120
+GP
+
++ + + + S +A
+
Sbjct:
61 ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWL----------
110
Query:
121 PSSSSVLGFRG--VTCRTWERTKPLRRFSIATLRDFGVGKRGIKEVSRRRRASSSRPSRA 178
F+G VTCRTWERTKPLRRFSIATLRDFGVGKRGIKE+ +
Sbjct:
111 --------FKGYGVTCRTWERTKPLRRFSIATLRDFGVGKRGIKEIQEK------AGFLI 156
Query:
179 RAVSRTPRVWRREKENTQGEEPARVLSSIDPTFFLSRTTSNVISSIVFGDRFDYEDKSSC 238
+AV
T+G
SSI PTFFLSRTTSNVISSIVFGDRFDYEDK
Sbjct:
157 KAV-----------*GTRG-------SSIYPTFFLSRTTSNVISSIVFGDRFDYEDK--- 195
Query:
239 KHLNRYPFLFNIFTSPTLIPEHLNKSPQSRPNKSHSHQFLPPDSSPSLPILSLQPQLYEM
298
K L+ +
F
QF P + +LYEM
Sbjct:
196 KFLSLLCMMLESF------------------------QFTAPSTG----------ELYEM
221
Query:
299 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 352
FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ
Sbjct:
222 FSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQCTLDPNSPRDFIDSFLIRMQ 275
>CYP2B6 AC023172.1 CDS (hIIB1) cryptic exon 3A = 18813-18856 (hIIB2)
human
on bottom, chimp XP_512679 on top
Score = 471 bits (1211), Expect = e-135
Identities = 232/245 (94%), Positives =
240/245 (97%)
13
differences in a partial sequence, missing about 160 aa
Query:
1 MLCGVEAIREALVDKAEAFSGRGKIAIMDPVYQGYGVLFANGNRWKVLRRFSVTIMRDFG
60
MLCGVEAIREALVDKAEAFSGRGKIA++DP ++GYGV+FANGNRWKVLRRFSVT
MRDFG
Sbjct:
77 MLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFG
136
Query:
61 MGKRSVEERIQDEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL
120
MGKRSVEERIQ+EAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL
Sbjct:
137 MGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFL
196
Query:
121 KMLNLFYQTFSLISSISSQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL
180
KMLNLFYQTFSLISS+ QLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL
Sbjct:
197 KMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETL
256
Query:
181 DPSAPKDLIDTYLLHMEKEKSDAHSEFSHQNLTLNTLSLFFAGTETTSTTLRYGFLLMLK
240
DPSAPKDLIDTYLLHMEKEKS+AHSEFSHQNL LNTLSLFFAGTETTSTTLRYGFLLMLK
Sbjct:
257 DPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLK
316
Query:
241 YPHVA 245
YPHVA
Sbjct:
317 YPHVA 321
>CYP2C8
M17397 human on bottom, chimp XP_508183 on top
Length = 490
12
aa diffs
Score
= 111 bits (278), Expect = 4e-27
Identities = 53/56 (94%), Positives =
54/56 (96%)
Query:
1 MEPFVVLVLCLSFMLLFSLWRQSSGRRKLPPGPTPLPIIGNMLQIDVKDICKSFSN 56
MEPFVVLVLCLSFMLLFSLWRQS RRKLPPGPTPLPIIGNMLQIDVKDICKSF+N
Sbjct:
1 MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTN 56
Score = 858 bits (2217), Expect = 0.0
Identities = 422/442 (95%), Positives =
426/442 (96%), Gaps = 8/442 (1%)
Query:
120 FSKVYGPVFTVYFGMNPIVVLHGYEAVKEALIDNGEEFSGRGSSPISQRITKGLGIISSN 179
FSKVYGPVFTVYFGMNPIVV HGYEAVKEALIDNGEEFSGRG+SPISQRITKGLGIISSN
Sbjct:
57 FSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN 116
Query:
180 GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN
239
GKRWKEIRRFSLT LRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN
Sbjct:
117 GKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCN
176
Query:
240 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLTN 299
VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVL N
Sbjct:
177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKN 236
Query:
300 VALTQSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV
359
VALT+SYIREKVKEHQASLDVNNPRDF+DCFLIKMEQEKDNQKSEFNIENLVGTVADLFV
Sbjct:
237 VALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKDNQKSEFNIENLVGTVADLFV
296
Query:
360 AGTETTSTTLRYGLLLLLMHPEVTAKVQEEIDHVIGRHRTPCMQDRSHMPYTDAVVHEIQ 419
AGTETTSTTLRYGLLLLL HPEVTAKVQEEIDHVIGRHR+PCMQDRSHMPYTDAVVHEIQ
Sbjct:
297 AGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQ 356
Query:
420 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMTLLTSVLHDDKEFPNPNIFDPGHFLDKN 479
RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIM LLTSVLHDDKEFPNPNIFDPGHFLDKN
Sbjct:
357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416
Query:
480 GNFKKSDYFMPFSAGNRNSFPFENEFAAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
539
GNFKKSDYFMPFSAG R AGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
Sbjct:
417 GNFKKSDYFMPFSAGKR--------ICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLN
468
Query:
540 TTAVTKGIVSLPPSYQICFIPV 561
TTAVTKGIVSLPPSYQICFIPV
Sbjct:
469 TTAVTKGIVSLPPSYQICFIPV 490
>CYP2C9
M61857 human on bottom, chimp XP_507939 on top
Length = 490
Score = 947 bits (2447), Expect = 0.0
Identities = 472/490 (96%), Positives =
476/490 (97%), Gaps = 8/490 (1%)
Small
disagreement on assembly, otherwise only 3 aa diffs
Query:
1
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNVSML 60
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTN+S +
Sbjct:
1
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV 60
Query:
61 ------LQWLAK--VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
112
L + K VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
Sbjct:
61 YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
120
Query:
113 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 172
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
Sbjct:
121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180
Query:
173 IIFHKRFDYKDQQFLNLMEKLNENVKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
232
IIFHKRFDYKDQQFLNLMEKLNEN+KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
Sbjct:
181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
240
Query:
233 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 292
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
Sbjct:
241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300
Query:
293 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 352
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
Sbjct:
301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360
Query:
353 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 412
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
Sbjct:
361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420
Query:
413 KSNYFMPFSAGKRICVGEALARMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
472
KS YFMPFSAGKRICVGEALA MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
Sbjct:
421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
480
Query:
473 PFYQLCFIPV 482
PFYQLCFIPV
Sbjct:
481 PFYQLCFIPV 490
>CYP2C19
M61854 human on bottom, chimp XP_507938 on top
Missing
N-term, only 4 aa diffs
Score = 774 bits (1998), Expect = 0.0
Identities = 392/425 (92%), Positives =
393/425 (92%), Gaps = 26/425 (6%)
Query:
1
MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 60
MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN
Sbjct:
74
MVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRN 133
Query:
61 FGMGKRSIEDRVQEEARCLVEELR------------------NVICSIIFQKRFDYKDQQ
102
FGMGKRSIEDRVQEEARCLVEELR
NVICSIIFQKRFDYKDQQ
Sbjct:
134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ
193
Query:
103 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMERDILEKVKEHQE 162
FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFME DILEKVKEHQE
Sbjct:
194 FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE 253
Query:
163 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 222
SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL
Sbjct:
254 SMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLL 313
Query:
223 LKHPEVTVLTRVLSAKVQEEIERVIGRKPEPCCMQDRGHMPYTDAVVHEVQRYIDLLPTS 282
LKHPEVT AKVQEEIERVIGR
PC MQDRGHMPYTDAVVHEVQRYIDL+PTS
Sbjct:
314 LKHPEVT-------AKVQEEIERVIGRNRSPC-MQDRGHMPYTDAVVHEVQRYIDLIPTS 365
Query:
283 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDKKEFPNPEMFDPRHFLDEGGNFKKSNYF 342
LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHD KEFPNPEMFDPRHFLDEGGNFKKSNYF
Sbjct:
366 LPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYF 425
Query:
343 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGLASVPPFYQL 402
MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG ASVPPFYQL
Sbjct:
426 MPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQL 485
Query:
403 CFIPV 407
CFIPV
Sbjct:
486 CFIPV 490
>CYP2D6
NM_000106 human on bottom, chimp Q2XNC8, ABB77911 on top
swissprot
entry, best annotation
8
aa diffs
Score = 995 bits (2572), Expect = 0.0
Identities = 489/497 (98%), Positives = 494/497 (99%)
Query:
1 MGLEALVPLAVIVTIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
60
MGLEALVPLAVIV IFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
Sbjct:
1 MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
60
Query:
61
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
Sbjct:
61
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF 120
Query:
121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
Sbjct:
121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
Query:
181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAIPVLLHIPALAGKV 240
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNA+PVLLHIPALAGKV
Sbjct:
181 AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV 240
Query:
241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
Sbjct:
241 LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA 300
Query:
301 DLFSAGIVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQARMPYTTAVI 360
DLFSAG+VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA MPYTTAVI
Sbjct:
301 DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI 360
Query:
361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLFTNLSSVLKDKAVWEKPFRFHPEHF 420
HEVQRFGDIVPLG+THMTSRDIEVQGFRIPKGTTL TNLSSVLKD+AVWEKPFRFHPEHF
Sbjct:
361 HEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF 420
Query:
421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
Sbjct:
421 LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV 480
Query:
481 FAFLVTPSPYELCAVPR
497
FAFLV+PSPYELCAVPR
Sbjct:
481 FAFLVSPSPYELCAVPR
497
>CYP2D8P1 = CYP2D8P AL021878 comp(55779-60892)
human
on bottom, chimp XP_520854 (2D42) on top
9
aa diffs
Score = 213 bits (543), Expect = 1e-58
Identities = 110/119 (92%), Positives =
111/119 (93%)
Query:
1 MLNVVPLLLRIPGLAGKVLCSQKAFLTQLDELLTEHRMIWDPAQPPGDLTEAFLAEMEKA 60
MLNVVPLLLRIPGLAGKVL SQKAFLTQLDELLTEHRMIWDPA PP DLTEAFLAE EKA
Sbjct:
222 MLNVVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMIWDPA*PPRDLTEAFLAEKEKA 281
Query:
61 KGNPESSFNDENLCMVVADLFLAGMVTTSVTLAWGLLLMILHPDVQRRVQQIDNVIGQV 119
KGNPESSFNDENL MVVADLF AGMVTTS+TLAWGLLLMIL PDVQ RVQQIDNVIGQV
Sbjct:
282 KGNPESSFNDENLRMVVADLFFAGMVTTSITLAWGLLLMILRPDVQARVQQIDNVIGQV 340
>CYP2E1
J02843 human bottom chimp XP_508139 top
Length = 493
Score = 658 bits (1698), Expect = 0.0
Identities = 318/322 (98%), Positives =
321/322 (99%)
7
amino acid differences plus a gap of 25 amino acids
Query:
1
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL
Sbjct:
1
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
Query:
61
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP
Sbjct:
61
AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
Query:
121 TWKDIRRFSLTTLRNYGMGKEGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
180
TWKDIRRFSLTTLRNYGMGK+GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
Sbjct:
121 TWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVI
180
Query:
181 ADILFRKHFDYDDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSVLHYLPGSHRKVIKNVA 240
ADILFRKHFDY+DEKFLRLMYLFNENFHLLSTPWLQLYNNFPS LHYLPGSHRKVIKNVA
Sbjct:
181 ADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVA 240
Query:
241 EIKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
300
E+KEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
Sbjct:
241 EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAG
300
Query:
301 TETTSTTLRYGLLILMKYPEIE 322
TETTSTTLRYGLLILMKYPEIE
Sbjct:
301 TETTSTTLRYGLLILMKYPEIE 322
Sequence
gap
Query:
741 PYMDAVVHDVQRFITLVPSNLPLEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE
800
PYMDAVVH++QRFITLVPSNLP EATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE
Sbjct:
348 PYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPE
407
Query:
801 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 860
KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK
Sbjct:
408 KFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPK 467
Query:
861 DIDLSPIHIGFGCIPPRYKLCVIPRS 886
DIDLSPIHIGFGCIPPRYKLCVIPRS
Sbjct:
468 DIDLSPIHIGFGCIPPRYKLCVIPRS 493
>2F1P
AC008537.3 93% identical to 2F1
human
on bottom, chimp XP_512682 on top
4
aa diffs
Score = 327 bits (838), Expect = 2e-92
Identities = 157/168 (93%), Positives =
159/168 (94%)
Query:
96 GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYNIFP 155
GEPFDPTFVLSRS SNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELY+IFP
Sbjct:
1 GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFP 60
Query:
156 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIDCFLTKMAEKKEDPLS 215
SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI CFLTKMAEKKEDPLS
Sbjct: 61 SLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFI