P450s that have appeared since the 1993 P450 nomenclature update.
This is Part B of the P450 bibiographic files.
Sequences covered are CYP3 to CYP9.
This list now includes all Drosophila P450s
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list.
Added 4A23-4A25, 6X1 9J1, 9J2,
4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2
Added all human genes and pseudogenes
Added CYP8B1 pig
Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
Added 25 Aedes and 104 Anopheles sequences
Added CYP9G2
This list was last revised on April 7, 2003.
Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
July 2, 2003 added 4F42, 3A64, 4T6, 4T7
Last revised Aug 19 2003, added 9A12
Last revised Sept 26, 2003 added accessions for some old seqs.
Last revised July 8, 2004 added Anopheles funestus CYP9s
Last revised Jan. 31, 2005 added Anopheles funestus CYP6s and 4C25
Last revised March 17, 2005 added Anopheles funestus CYP9L4 and 9K1
Last revised June 24, 2005
Last revised Jan. 4, 2006
Last revised Dec. 31, 2007
3A Subfamily
4A Subfamily
4B Subfamily
4C Subfamily
4D Subfamily
4E Subfamily
4F Subfamily
4G Subfamily
4H Subfamily
4J Subfamily
4K Subfamily
4L Subfamily
4M Subfamily
4N Subfamily
4P Subfamily
4Q Subfamily
4R Subfamily
4S Subfamily
4T Subfamily
5A Subfamily
6A Subfamily
6B Subfamily
6C Subfamily
6D Subfamily
6E Subfamily
6F Subfamily
7A Subfamily
7B Subfamily
8A Subfamily
8B Subfamily
9A Subfamily
9B Subfamily
9C Subfamily
3A Subfamily
CYP3A1 rat
GenEMBL D13912 (2023bp)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of steroid-
induced cytochrome P450 3A in rats
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: only 11 differences and two missing amino acids with
3A1. All changes are limited to a 113 amino
acid region, M10161 probably represents a hybrid seq. with Cyp3a2.
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S30378 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL L24207 (2015bp)
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
Unpublished (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of
steroid-induced cytochrome P450 3A1 in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL M28452 (897bp)
Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
Demonstration in multiple species of inducible hepatic cytochromes
P-450 and their mRNAs related to the glucocorticoid-inducible
cytochrome P-450 of the rat
Mol. Pharmacol. 28, 312-321 (1985)
Komori,M. and Oda,Y.
PIR JX0334 (502 amino acids)
A major glucocorticoid-inducible P450 in rat liver is not 3A1.
J. Biochem. 116, 114-120 (1994)
Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S36137 (30 amino acids)
Ribeiro, V. and Lechner, M.C.
Cloning and characterization of a novel CYP3A1 allelic
variant: Analysis of CYP3A1 and CYP3A2
sex-hormone-dependent expression reveals that the CYP3A2
gene is regulated by testosterone.
Arch. Biochem. Biophys. 293, 147-152 (1992)
This sequence agrees exactly with PIR JX0334, a 3A1 variant
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S27107 (24 amino acids)
PIR S21697 (504 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A2 rat
GenEMBL M74443 (4230bp) U09725 to U09734 13 exons
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
U09725-U09734 report corrections to M74443
CYP3A2 rat
Gen EMBL X79319 (8014bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL U09742 (1936bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2:
Comparison of the cDNA with P450PCN2.
unpublished (1994)
CYP3A2 rat
Yamazoe,Y. et al.
Transcriptional elements directing a liver-specific expression of
P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
Arch Biochem Biophys. 318, 71-79 (1995)
CYP3A2 rat
PIR S30379 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
CYP3A2 rat
GenEMBL S45634 (1572bp)
PIR S27108 (36 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
CYP3A2 rat
UCSC Browser chromosome 12
9570862 MDLLSALTLETWVLLAVILVL 9570800
9570429 LYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK 9570328
9566707 GLGRFDMECYKKYGKIWG 9566654
9564529 LFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR 9564431
9559660 DFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKE 9559547
9559467 MFPIIEQYGDILVKYLKQEAETGKPVTMKK 9559378
9559082 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSV 9558936
9556537 VLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHK 9556409
9555511 HRVDFLQLMLNAHNNSKDEVSHK 9555443
ALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK in a seq gap
9551883 APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG
SVVTIPTYALHHDPQHWPKPEEFHPE 9551659
9550394 RFSKENKGSIHPYVYLPFGNGPRNCIDMRFALMNMKLALTKVLQNFSFQPCKETQ 9550230
9547469 IPLKLSRQAILEPEKPIVLKVLPRDAVINGA 9547377
CYP3A3X human
PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
Complete cDNA sequence of a cytochrome P-450 inducible by
glucocorticoids in human liver.
Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
This number is discontinued the seq = CYP3A4
CYP3A4 human
GenEMBL D11131 (1345bp)
Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
Kamataki,T. and Itoh, S.
Gene structure of CYP3A4 an adult-specific form of cytochrome
P450 in human
livers and its transcriptional control.
Eur. J. Biochem. 218, 585-595 (1993)
CYP3A4 human
GenEMBL J04449 (2849bp)
Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and
Guengerich,F.P.
Characterization of mRNA species related to human liver cytochrome
P-450 nifedipine oxidase and the regulation of catalytic activity.
J. Biol. Chem. 264, 910-919 (1989)
nf-10 nifedipine oxidase (IIIA3)
CYP3A4 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a4
93% to 3A4 human
CYP3A4 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a4
93% to 3A4 human
CYP3A4-ie1b human
GenEMBL NT_007933.10|Hs7_8090
alt exon 1 (partial)
24614522 LIPNLAVETWLLL 24614484
CYP3A4v1 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
CYP3A4v2 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
1 aa diff to 3A4v1, 4 nuc. diffs
CYP3A5_v1 human
PIR A60558 (29 amino acids)
Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
Identification of a polymorphically expressed member of the
human cytochrome P-450III family.
Mol. Pharmacol. 36, 97-105 (1989)
CYP3A5_v1 human
GenEMBL S74699 (1526bp) S74700 (1667bp)
Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
Sequence of the 5'-flanking region of CYP3A5: comparative analysis
with CYP3A4 and CYP3A7.
Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)
CYP3A5_v1 human
GenEMBL AC005020 genomic sequence 13 exons
Same intron exon structure as CYP3A43 from human
CYP3A5-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7
alt exon 1 and 2 upstream of 3A5
239409 MDLIPNLAVETWLLLAVSLVLLYL
243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697
CYP3A5-de13c human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 detritus exon 13 upstream of 3A5
old name = 3A51P
254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
CYP3A5_v2 human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
formerly CYP3A5P1, new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5_v3 human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
formerly CYP3A5P2, new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P1X human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P2X human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology formerly CYP3A66
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A5_2-F5
3 aa diffs to 3A5 Macaca mulatta
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
91% to 3A5 human, 84% to 3A4, 80% to 3A7, 75% to 3A43
100% identical to Unos seq.
CYP3A5 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5b
89% to 3A5 human, probable ortholog of CYP3A5
note: there is a second gene CYP3A90 that is 95% identical to this
it is a paralog of the CYP3A5 gene
CYP3A5 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a5
98% to 3A5 human
CYP3A6 rabbit
GenEMBL J05034, M19139
CYP3A7 human
NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
CYP3A7-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 alt exon 1 and 2 upstream of 3A7
186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2
CYP3A7 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
89% to human CYP3A7, 89% to human CYP3A4
82% to human 3A5 and 73% to 3A43
note: this seq is equally similar to 3A7 and 3A4
but there is another seq with a better match to
3A4 in African green monkey, so this must be
the 3A7 ortholog
CYP3A7 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a7
96% to 3A7 human
CYP3A7 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a7-like
92% to 3A7 human
CYP3A7 Macaca mulatta (rhesus monkey)
AANU01101873.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a7-like
91% to 3A7 human
24981 MDLIPDLAVETWLPLAVSLILLYL
YGTHSHGLFKKLGIPGPTPLPFFGNVLSFRK 29288
34310 GFWTFDMECYKKYRKVWG 34363
35908 FYDCRQPVLAITDPNMIKTVLVKECYSVFTNRR 36006
38516 PLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKE 38629
38894 MVPIIAQYGDVLVRNLRREAETGKPVTLKD 38983
40270 VFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDPFFLSIK 40416
41507 IFPFLTPIFEALNITVFPRKVTRFLRKSVKRMKEGRLKETQK 41632
42652 RRVDFLQLMIDSQNSKDTESHK 42717
45311 VLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDTVLPNK 45472
46900 APPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGVVVMIP
47094
47095 SYVLHHDPKYWTEPEKFLPER
48220 RFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 48384
51270 IPLKLSFGGLLKTEKPIVLTAESRDGTVSGA* 51371
CYP3A8 Macaca fasicularis (monkey)
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP3A8 Macaca fasicularis (monkey)
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A8 Macaca fasicularis (monkey)
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A9 rat
GenEMBL U46118(2101bp)
Wang,H., Kawashima,H. and Strobel,H.W.
cDNA cloning of a novel CYP3A from rat brain
Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)
CYP3A9 rat
GenEMBL U60085(1882bp)
Nef,P.
Hepatic expression and inducibilty of CYP3A9 and other members of
the rat CYP3A subfamily.
unpublished (1996)
CYP3A9 rat
UCSC Browser chromosome 12
some frameshifts in genome seq of exon 8
17153442 MDLIPNFSMETWLLLVISLVLLYL 17153513
17155488 YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK 17155580
17156990 GFWEFDKYCHKKYGKLWG 17157043
17159222 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17159320
17163193 NFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKE 17163306
17163523 MFPIINQYTDMLVRNMRQGSEEGKPTSMKD 17163606
17165013 IFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSV 17165159
17168128 TLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKE 17168226 NRMKEKEK
17170690 QRMDFLQLMINSQNSKVKDSHK 17170755
17177660 ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK 17177821
17179040 AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
VVMIPTFALHKDPHYWPEPEEFRPE 17179264
17191573 RFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKET 17191734
17192800 QIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA 17192895
CYP3A9-se1[4]X rat
UCSC Browser chromosome 12
Note: the revised genome probably has this as part of Cyp3a62
Discontinued name
17387311 LYEGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17387213 exon 4
CYP3A9-se1[1:2:4] rat
193 kb downstream of Cyp3a9 on opposite strand
100% match to Cyp3a9
MDLIPNFSMETWLLLVISLVLLYL
YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK
LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR
CYP3A10 hamster
GenEMBL M73992 (2015bp)
Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequence of a new rat CYP3A form
unpublished (1993)
Cyp3a11 mouse
PIR A60564 (24 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
Cyp3a11 mouse
GenEMBL X60452, AC111090.20 genomic clone (seq shown)
104114 MDLVSALSLETWVLLAISLVLLYR 104185
106160 YGTRKHELFKKQGIPGPKPLPFLGTVLNYYK 106252
108416 GLWKFDMECYKKYGKTWG 108469
110360 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR 110458
114653 DFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKE 114766
114846 MFPVIEQYGDILVKYLRQKAKKGKPVTMKD 114935
115207 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSV 115353
117878 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQK 118006
118896 HRVDFLQLMMNSHNNSKDKVSHK 118964
121382 ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK 121543
123352 APPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALH
HDPQHWSEPEEFQPER 123579
125008 FSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 125169
128728 IPLKLSRQGLLQPEKPIVLKVVPRDAVITGA 128820
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a11-de12bX mouse
old name Cyp3a-se11[12] also = Cyp3a-se6[12]
this fragment has joined with Cyp3a44-de9b10b11b
to make Cyp3a44-de9b10b11b12b (see below)
137165 RFSMENKGSIDPY 137127
137122 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 136997
CYP3A12 dog
PIR S04341 (28 amino acids)
Ciaccio, P.J. and Halpert, J.R.
Characterization of a phenobarbital-inducible dog liver
cytochrome P450 structurally related to rat and human
enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Arch. Biochem. Biophys. 271, 284-299 (1989)
Cyp3a13 mouse
GenEMBL X63023(1881bp) also NT_039315.1
Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
Molecular cloning and functional expression of a mouse cytochrome
P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
aflatoxin B1 (AFB1).
Biochim. Biophys. Acta 1201 (3), 405-410 (1994)
CYP3A14 Cavia cobaya (guinea pig)
GenEMBL D16363 (1827bp)
Mori,T., Itoh,S. and Kamataki,T.
cDNA and deduced amino acid sequence of a novel cytochrome
P450 from male guinea pig liver mRNA with high homology to
CYP3a family
unpublished (1993)
CYP3A14 Cavia porcellus (guinea pig)
GenEMBL D49731 (2321bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
CYP3A15 Cavia cobaya (guinea pig)
GenEMBL D26487 (2163bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
Cyp3a16 mouse
GenEMBL D26137 (1701bp) also NT_039318
Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning
and expression in fetal liver.
Eur. J. Biochem. 226, 877-882 (1994)
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a16-de12b mouse
GenEMBL NT_039318 - strand
detritus exon 12
z in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1616751 GPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1616647
CYP3A17 guinea pig
GenEMBL D28515
Mori,T.
submitted to Nomenclature Committee
Not in Genbank as of 6/26/95
CYP3A18 rat
no accession number
Kiyoshi Nagata
6-beta-C
submitted to Nomenclature Committee
CYP3A18 rat
GenEMBL X79991 (2005bp)
Strotkamp,D., Roos,P.H. and Hanstein,W.G.
A novel CYP3 from female rats.
Biochim. Biophys. Acta 1260, 341-344 (1994)
CYP3A18 rat
GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
Yamazoe,Y. et al.
Isolation and characterization of of a new rat P450 (CYP3A18) cDNA
encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
Pharmacogenetics in press (1995)
CYP3A18 rat
UCSC Browser chromosome 12
9166475 MEIIPNLSIETWVLLATSLMLFYI 9166404
9156355 YGTYSHGLFKKLGIPGPKPVPLFGTIFNYGD 9156263
9143764 GMWKFDDDCYKKYGKIWG 9143711
9141173 FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR 9141075
9137566 CFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKE 9137453
9136038 MFPLMRQYGDTLLKNLRREEAKGEPINMKD 9135949
9135719 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSV 9135573
9133657 VLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQK 9133529
9132027 NRVDFLQLMMNTQNSKGQESQK 9131965
9129047 ALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK 9128886
9126077 APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
VVTIPIYPLHRNPEYWLEPEEFNPE 9125853
9120566 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 9120405
9117192 QIPLKISRQPIFQPEGPIILKLVSRD 9117115
CYP3A18-se1[5:6:7:8] rat
UCSC Browser chromosome 12
64% to 3A18
9216052 FGPVGFMKKAVTISEDDEGKRLRPLLSPVFTSGK 9216153
9216386 LWLLHFGLMCSPSSGSVMSVKHLRQEEKGEPIHMKE 9216493
9216722 FSGAYSMNGIAGASFGVNVDSLNN 9216781
XXXXXXXXXXXXXXXXXXXXXXXX
VVLFPFLTQI
CYP3A19 Capra hircus (goat)
GenEMBL X76503 (1084bp)
Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
cDNA and deduced amino acid sequence of a dwarf goat liver
cytochrome P450-fragment belonging to the CYP2C gene subfamily
Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
C-terminal fragment from I-helix to end
CYP3A20 Guinea pig
GenEMBL
T. Mori
unpublished
CYP3A21 Marmoset
GenEMBL
Igarishi, T.
unpublished
CYP3A22 Miniature pig
GenEMBL AB006010
Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
Drug Metab. Disp. 32, 376-378 (2004)
CYP3A23 rat
GenEMBL D13912
Kirita,S. and Matsubara,T.
Cloning and characterization of a novel member of steroid induced
cytochrome P450 3A in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
GenEMBL D29967
Komori,M. and Oda,Y.
A major glucocorticoid inducible P450 in rat liver is not P4503A1
J. Biochem. 116, 114-120 (1994)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
UCSC Browser chromosome 12
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
9625823 MDLLSALTLETWVLLAVVLVLLY 9625755
9623782 GFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM 9623687
9621110 GLWKFDVECHKKYGKIWG 9621057
9617991 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR 9617893
9616272 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKE 9616159
9616079 MFPVIEQYGDILVKYLRQEKGKPVPVKE 9615996
9615715 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV 9615569
9614012 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDS 9613893
9613004 VQKHRVDFLQLMMNAHNDSKDKESHT 9612936
9607896 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNK 9607735
9605981 APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKG
SVVMIPSYALHRDPQHWPEPEEFRPE 9605757
9604349 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 9604188
9597247 QIPLKLSRQGLLQPTKPIILKVVPRDEIITGS 9597152
CYP3A24 sheep
GenEMBL U59378(1653bp)
Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
and Morgan,D.J.
Ovine foetal liver CYP3A24
unpublished (1996)
Cyp3a25 mouse
GenEMBL AF204959
Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
submitted to Nomenclature Committee 10/18/96
Cloning, sequencing, heterologous expression and characterization
of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
Unpublished
MELIPNLSIETWVLLVTSLVLFYI
YGTYSHGLFKKLGIPGPKPLPLLGTIFNYYD
GMWKFDEDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
FFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPISMKD
IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKVFDPFLLS
IILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ
IPLKISREPIFQPEKPIILKVVSRDKPRTGS
Cyp3a25 mouse
GenEMBL Y11995
Mahnke,A., Roos,P. and Hanstein,W.G.
one amino acid difference with Roses sequence at amino acid 215
unpublished
Cyp3a25 mouse
GenEMBL AC111090.20 genomic clone
Last two exons. This clone also contains CYP3a11, Cyp3a44 and the
region between them. This helps to close the gap in the 3a cluster
shown in Fig 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
2345 FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 2506
6188 IPLKISREPIFQPEKPIILKVVSRDKPRTGS 6280
Cyp3a25-de8b9b12b mouse
GenEMBL AC111090.20 genomic clone
r in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
27841 PVFFSFLIPI*EMLNISVFQKGSIAFFKKFVDRMNESRPDSKQK 27710
18903 DLVGFLQPMINAHNNPKDKESHNG 18832
15460 XXXXXXGSID-YVYLSFGNGPRIYIGVRFTLMNMKVLTLTKVLHNFSFHPCKET* 15317
Cyp3a25-de11c mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
q in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
168333 XPVTLGTLVEIEYPDMVVT*ILILYPIGNRPESVCKEGFEVFIPKGTRVTVPTFALH*DPQYWPELEKXXXXX 168133
CYP3A26 dog
no accession number
David Fraser
submitted to Nomenclature Committee
95.6% identical to 3A12 from dog
CYP3A27 Oncorhynchus mykiss (rainbow trout)
GenEMBL U96077
Don R. Buhler
Arch. Biochem. Biophys. 360, 000-000 (1998) in press
56% identical to 3A12
CYP3A28 Bos taurus (cow)
GenEMBL Y10214(1870bp)
Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
Witkamp,R.F. and Horbach,G.J.
Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
and its functional expression in V79 cells.
unpublished (1997)
CYP3A28 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLATSLVLLYI (2)
YGTYSYGLFKKLGIPGPRPVPYFGSTMAYHK (0)
GIPEFDNQCFKKYGKMWG (2)
FYEGRQPMLAITDPDIIKTVLVKECYSVFTNRR (0)
IFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKE (0)
MFPIIGQYGDMLVRNLRKEAEKGNPVNMKD (2)
MFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSI (1)
ILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQM (0)
NRVDLLQLMINSQNSKEIDNHK (1)
ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNK (0)
APPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPER (2)
FSKNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQ (0)
IPLKLYTQGLTQPEQPVILKVVPRGLGPQVEPDFL*
CYP3A29v1 pig
GenEMBL Z93099 (2015bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA
CYP3A29v2 Sus scrofa (pig)
GenEMBL AB052260
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
2 amino acid diffs with 3A29v1
clone name 3Ac9
CYP3A29v3 Sus scrofa (pig)
GenEMBL AB052261
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1
clone name 3Ac16
CYP3A29v4 Sus scrofa (pig)
GenEMBL AB052262
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
clone name 3Ac25
CYP3A29v5 Sus scrofa (mini pig)
GenEMBL AF424780
Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
cDNA of minipig cytochrome P450 3A
Unpublished
75% to 3A4 human 98% to 3A29v1 8 diffs.
3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
4 diffs with 329v2 (Partial seq from 99-328)
CYP3A30 Fundulus heteroclitus
Genbank AF105068
Malin Celander and John J. Stegeman
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the
marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A
genes.
Biochem. Biophys. Res. Commun. 236, 306-312 (1997)
CYP3A31 Syrian hamster
GenEMBL D86951
Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
Nagata,K. and Yamazoe,Y.
cDNA cloning and expression of a novel CYP3A from the Syrian
hamster, CYP3A31
Biochim. Biophys. Acta 1397, 9-13 (1998)
clone name P450SH3A-1
CYP3A32 Balaenoptera acutorostrata (Minke whale)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A33 Phocoenoides dalli (Dall's porpoise)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A34 Eumetopias jubatus (Steller sea lion)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A35 Phoca largha (Spotted seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A36 Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A37 Gallus gallus (chicken)
no accession number
Manuel Baader and Urs Meyer
submitted to nomencalture committee
60% identical to mammalian CYP3A sequences
CYP3A37 Gallus gallus (chicken)
GenEMBL NM_001001751.1
Note: chicken has two CYP3As about 25kb apart on chr 14
See CYP3A80
MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI
QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI
ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ
QKVVNEIDTILPNKAPLTYEAIMQLEYLDMAVNETLRLYPLGGRLERTCKRDVEINGV
TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG
MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPRTNTAKA
CYP3A37 Meleagris gallopavo (turkey)
No accession number
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F4
92% to chicken 3A37 probable ortholog
CYP3A37 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_1137:6582-24650,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca4.
69% to CYP3A37 chick (ortholog), 64% to CYP3A113,
63% to CYP3A98 dog, 63% to 3A80 chicken
MELLPSFSIETWSFLVVLLGLLLLYGIWPFGVFGKLGIPGPRPWPFLGTLLQYRKGFVKFDSWCFQKYGRIWGIYDGRQPVM
AILDPAIIKTVLVKECYTTFTNRRNFGATGVLKSAISLAEDEHWKRVRTVLSPTFTSGKLKEMFPIIKHYGEALMRNVQKKV
DMDEPLVVKDVFGAYAMDVVTSTSFGVNIDSMNNPKDPFVKEIQKLTKFRSFDPRIILLFTFPILRTVFEALNIQIFSAEAV
DFFTRSFAKMKAGRAGETKEGRVDFLQLMIDSQTSNGHHQSNGIDHTYKGLTDDEILAQAFIFVFAGYEPTSNSLGYMAYML
ATHPDVQQKLQDEIDSVLPNKAPLTYDAIMQLEYLDMVLNETQRLYPLGGRIERVCKKDVEINGVTIPKGVVVMIPPYNLHR
DQEYWPEPEEFRPERFSKENKESVDPYTYLPFGAGPRNCIGMRFALVTMKVAITILLQHFSFRVCKETPIPLELSSQAFLVP
EKPIVLKLVRRNNLQ
CYP3A38 Medaka (fish)
no accession number
Seth Kullman
submitted to nomenclature committee 11/6/98
72% identical to CYP3A27 trout
CYP3A39v1 Sus scrofa (pig)
GenEMBL AF109068, NM_214422
Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
Porcine Cytochrome-P450 with high protein homology to human CYP3A4
(Nifedipine oxidase J04449)
Unpublished
88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA
CYP3A39v2 Sus scrofa (pig)
GenEMBL AB052263
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
clone name 3Ac13
CYP3A39v3 Sus scrofa (pig)
GenEMBL AB052264
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
clone name 3Ac19
CYP3A39v4 Sus scrofa (pig)
GenEMBL AB052265
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
clone name 3Ac32
CYP3A39v5 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence with frameshifts before I-helix
95% to CYP39A1v1 NM_214422
only 2 aa diffs in first 193 aa
CYP3A40 medaka
no accession number
Seth Kullman
submitted to nomenclature committee 1/12/99
90% identical to CYP3A38 trout
Cyp3a41 mouse
GenEMBL NM_017396 AB033414
Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene
subfamily in the mouse liver
Arch. Biochem. Biophys. 377 (1), 153-162 (2000)
91% identical to 3a11 87% identical to 3a16 69% to 3a25 and
68% to 3a13 90% to 3a44
submitted to nomenclature committee 6/1/99
MNLFSALSLDTWVLLAIILVLLYR
YGTRTHGLFKKQGIPGPTPLPFLGTVLNYYK
GLWKFDMECYEKYGKTWG
LFDGQMPLFVITDPEMIKNVLVKECFSVFTNRR
EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKE
MFPVIEQYGDILVKYLMQEAEKGKPVTMKD
VLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFS
VVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQK
HRVDFLQLMMNAHNNSKDKDSHK
ALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK
APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPER
FSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ
IPLKLSRQGLLQPEKPIVLKVVPRDVVITGA
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a41-de1b2b mouse
GenEMBL NT_039318
exon 1,2 - strand
y in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
possible alternative exons for 3a41
1729618 MNLFSALSLDTLVLLAIILVLLYR 1729547
1727537 YGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK 1727445
Note: These two exons are identical to 3A16 exons 1 and 2
This sequence is at the edge of the genome sequence gap between 3a41 and 3a44
The NT_039318 sequence has been removed in the new mouse genome assembly,
So these sequences could be due to errors in assembly.
Cyp3a41-de12c mouse
GenEMBL NT_039318 - strand
detritus exon 12
x in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1739825 SNGPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1739715
note this seq is nearly identical to Cyp3a16-de12b
it is in a region of some uncertainty, and may be due to errors in assembly.
CYP3A42 Python regius (ball python or royal python, African snake)
GenEMBL AF319041
Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
Submitted to nomenclature committee Oct 22, 1999
59% to mouse 3a
CYP3A43 human
GenEMBL AC011904 8902-46787 13 exons
Gene assembled from genomic sequence by Henry Strobel
and David Nelson on Dec 11, 1999
intron exon boundaries defined by comparison to rat 3A9
and human 3A sequences. GT AG pairs found for all introns
ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
Opposite ends of same clone
67% identical to rat 3A9
Assembled gene * = intron exon boundary ** = EST support for this boundary
MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI*
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*
coding region 504 amino acids
exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787
CYP3A43-de1b human
GenEMBL NT_007933.10|Hs7_8090 + strand alternate exon 1
24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214
CYP3A43-de4c6c
GenEMBL NT_007933.12|Hs7_8090
chromosome 7 genomic contig
Length = 64383103
Last exon of 3A43 in build 33 of human genome
24697113 IPLKLDNLPILQPEKPIVLKVHLRDGITSGP* 24697208
CYP3A43-de4c6c = s in Fig. 3A,
old names = 3A52P, 3A53P
Exon 4 pseudogene fragment
24701048 MIKTVLVKECYSVFPNWR 24701101
exon 6 pseudogene fragment
24703375 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 24703464
CYP3A43 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A43
96% to human CYP3A43 only 75% to 3A4, 3A5
CYP3A43 Macaca mulatta (rhesus monkey)
XM_001098213.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a43
96% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETSLHHSLSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQLPLKLNNLPILQPENPIVLKVHLRDGITSGP
CYP3A43 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a43
98% to 3A43 human
Cyp3a44 mouse
GenEMBL AB039380
Tsutomu Sakuma
Submitted to nomenclature committee 2/29/2000
This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)
Cyp3a44 mouse
GenEMBL AC111090.20 genomic clone
This clone contains part of 3a25, Cyp3a25-de8b9b12b, 3a11,
A pseudogene between 3a11 and 3a44, and most of 3a44
178101 MNLFSALSLDTLVLLAIILVLLYR 178172
180134 YGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT 180226
182562 GIWKFDMECYEKYGKTWG 182615
184471 LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRR 184569
188874 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 188987
189067 MFPVIEQYGDILVKYLRQEAEKGMPVAMKD 189156
189424 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSV 189570
192147 VLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQK 192275
193171 HRVDFLQLMMNSHNNSKDKDSHK 193239
195368 AFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNK 195529
204141 ATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPS 204308
204309 YALHHDPQHWPDPEEF 204356 (runs off end, last section from AB039380)
QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLA
VTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA
Cyp3a44-de9b10b11b12b mouse
GenEMBL AC111090.20 genomic clone
This seq is between 3a11 and 3a44. It is 13kb from 3a44, 20kb from 3a11
The exon 12 part used to be called Cyp3a11-de12b
The exon 9 part is identical to w in Figure 3B Nelson et al.
Pharmacogenetics 14, 1-18 2004.
165130 HQVDFLHLMINAHDKTKDKETHK 165062
160280 ALSNMEITTQSIMFIFASYKPTSSTLSFALCSLVTHHAS*KKLQENDKTLTNK 160122
156349 VELESLDMVLNETLRLYPTADRLVKVYKKDVELNDAFILKWSLEIVSCYSLCHDPQNWPEHKEFCPE 156149
148858 RFSMENKGSIDPYG 148817
148815 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 148690
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Note: the following sequences (4 exons) lie between 3a41b and 3a44
Cyp3a41b-de12b
(-)15459 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQ 15298
3 aa diffs to Cyp3a-se5[12]
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A45 Oncorhynchus mykiss (rainbow trout)
No accession number
Su-Jun Lee, Don R. Buhler
96% to 3A27 but different 3 prime and 5 prime ends
CYP3A46v1 Sus scrofa (pig)
GenEMBL AB052266
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
clone name 3Ac4
CYP3A46v2 Sus scrofa (pig)
GenEMBL AB052267
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
clone name 3Ac28
CYP3A47X Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Renamed CYP3D1
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPPLHDPSTSP (1)
Cannot identify exon 8 in this region
(0) EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3A48 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803
CYP3A48 Tetraodon nigroviridis (freshwater puffer)
CAF91666 GenPept
85% to 3A48 full (probable ortholog), 87% to 3A49 C-term fragment,
MDLLPDFSIETWTLIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGVHHFDQECYKKYGKVWSLFDGRQPLM
CIMDTLMIKTILIKECYSNFTNRRDLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKV
KADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILVVLFPFTQTIFDKMDVSLFPGHVL
DFFYNFLRQIKSDRSKEKKKSRVDFMQLMVNAHMTEDNEKDSSLKGLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNP
DIQKKLQEEIDKTFPGKVRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPAL
WPEPEAFKPERFSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPI
KLKLKPRTSS
CYP3A48 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrXII:12771920-12775348, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
gac2628
70% to 3A48 Fugu, 72% to tetraodon 3A48,
MGFLPELSIQTWTLIVFLVTLITVYGYAPYGFFKKLGIPGPRPLPFIGTFLEYRKGIHNFDTECYEKYGKVWGIYDGRVPIL
VTMDTAMIKSILVKECYSNFTNRRDFGLNGALRDAITVVEDEEWKRIRSILSPSFTSGRLKEMYSIMLQHSGNLIKSLHKKA
EAGEVVDVKDIFGPYSMDVVASTAFSVDIDSINNPSDPFVANIRKLVKFTFLTPLFLLLVLFPFLEPMLDKMNVTLFPAELL
DFFYSFLKTIKSDRSKNEHKNRVDIMQLMVDSQMSETTKEDPSAHKGLSDSEILSQAMIFIFAGYETSSGTLGFLAYNLATN
PDIQKTLQEEIDETFPNKARPTYDALMQMEYLDMVLNESMRLYPSGNRLDRVSKSSVEIEGVTIPKGTVVMIPVYTLHREPT
LWPEPDDFKPERFSKENKDSIDPYSYLPFGAGPRNCIGMRFALLMMKLSVVEILQNFSFVTCKETQIPLELSTDGFTTPKDS
INLKLEPRGAHC
CYP3A49 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124b length 48103 gene runs off end of scaffold
48101 XXXXYEILAQ 48804 frameshift
48084 AIFFIFAGYELPAALLDFANNLATNPKIQKKLQEEIDKTFPGK 47956 (0)
47876 VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQ 47697
47696 RDPVLWPEPEAFKPER 47648 (2)
47492 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCQETD (0) 47331
47246 IPMVLGNEGFVTPKNPIKLKLKLRDVFN* 47160
CYP3A50P Fugu rubripes (pufferfish)
No accession number
Scaffold 10760 probable pseudogene
1847 MNFLPDFFLNTWTFLILVIVLSTT 1918 (2) exon 1
2258 bad boundary MDVLHMSSIKRVGIRRPKTWPIIGTYNRTDG 2350 bad boundary exon 2
cannot identify exons 3-6
3091 XXXXXXXXXXXXXXFSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG 3195 (1) part of exon 7
3268 AIFPFLTPLMD 3300 start of exon 8
Seq gap in scaffold
3919 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNLAVHPQTQTRLQAEIDRTFPGK 3990 exon 10
4078 CLITYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSGVIIPEGVAVAVPIYTLH 4257
4258 RDPTVWPDPDSFKPERFSKDNRDNIDPYGLLTR 4424 frameshift and 7 nuc. deletion
4423 GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM 4527
IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN* 4787
CYP3A51PX human
NT_033964.1|Hs7_34119 chromosome 7
detritus exon 13 upstream of 3A5
new name = CYP3A5-de13b
254205 QIPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
CYP3A52PX human
AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4
New name = CYP3A43-de4c6c
MIKTVLVKECYSVFPNWR
CYP3A53PX human
NT_033964.1|Hs7_34119 Homo sapiens chromosome 7
detritus exon 6 downstream of 3A43
new name = CYP3A43-de4c6c
67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6
CYP3A54PX human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
new name = 3A-se1[2]
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A55PX human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
new name = 3A-se2[5]
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
CYP3A56 Fundulus heteroclitus (killifish)
No accession number
Tove Hegelund and Malin Celander
64% to 3A48 Fugu 99% to 3A30
submitted to nomenclature committee 6/20/02
Cyp3a57 mouse
GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
AC115895.4 13 exons, exon 9 is backwards
NT_039318
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP
Cyp3a58-ps mouse
GenEMBL NT_039318 + strand
Between 3a16 and 3a41
Note this seq is 86% identical to Cyp3a44-de9b10b11b12b
[3a16, 3a58-ps, 3a41] is probably a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11]
exon 8
1629527 PVFFSFLNPI*EMLKISVFPKDSIAFFKKKLWTEQRKTSWILSKR 1629661
exon 9 new fron UCSC Browser
26701 HQVDFLHLMINAHDNTKDNESHK 26769
exon 10
1651425 ALSNIEITTQSIMFIFASYEPTSSTLSFVLYLLVTHHDIWKKLQENDRALPNK 1651583
exon 11
1660734 VEMEYLDMVLNETLRLYPTADRFVKVYKKDVELNDAFILKWS 1660859
exon 12
1669382 FSMENKGSIDPYX 1669417
1669422 YMPFGNGPRNCISMRFAVMSMKFALTKVLQNCYLHPCKETQ 1669544
Cyp3a59 mouse
GenEMBL NW_000248.1|Mm5_WIFeb01_96 gene interrupted by gaps
AC113316.2
old temp name = cyp3agg
93% to Cyp3a25
LLLYRYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFD
GMWKFDEDCYKKYGKIWG
FYVGPKPILAIMDPEIIKIVLVKECYSVFTNR
RLLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPINMKE
IFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLS
VVLFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLH
RNPEYWPEPQEFCPG
RFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQ
IPLKISREPVFQPEKPIILKVVSRDKPRT
Cyp3a59-de11b mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
p in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
191646 VSFLLVTLVEIEYLDILVT*ILRLNPIGNRLESVSKK 191536
191539 EMFEVFIPKGTRVTVLTFALH*DEQYWPEXXXXXXXX 191453
Cyp3a60-ps mouse
GenEMBL NT_039324.1 + strand
Cyp3a ps about 60% to 3A25
exon 2
331420 PVRLPVIGLLLSLYN 331464
exon 5
338061 KKVITISEEDERKRL*TLLSPTFIS 338135
exon 6
338410 MFPIIGQYGETLVK 338451
338451 KKRKGEPINMKE 338486
exon 7
338734 SMDVVTGTLFGVNVDSLTNSSDPCAESQGDLNKFEFS*PTSLG 338862
exon 8
341951 VAMLPFLTTIYKILSISIFP 342010
342409 KYMKQSRLDTNQK 342447
Cyp3a61-ps mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3ayyp
Exons 10,11,12,13
1115767 ALSDLEIVAQSISFIFAGYETTSNTLSYIMYTLATHPDVQKKLQQEIDAILPNK 1115606
1113252 APATYNDLEKIEYLDMVINETLRLYPIGARISRLSKKDAEINGVFIPQNTEVAVPVF 1113082
1109396 FSQENKDRINPYVYMPFGNGPRNCLGMRFALINMKLAVVKILQNFSVQPCEDTE (0) 1109235
1108058 IPLKLSKKLILSPEKPIVLKVTARDGAINEG* 7963
Cyp3a61-de11b mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3azzp
detritus exon 11 next to Cyp3a61-ps
n in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1136553 APATYNGLVKIRYLDMVINETLRLYPVGVRISRLSKKDAEINGVLTPQNTK
VDVALFVLH*DPEYWPXXXXXXXXX 1136353
CYP3A62 rat
GenEMBL AB084894
Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
Isolation and characterization of a novel rat CYP3A, CYP3AL1,
predominantly expressed in intestinal tract Unpublished 2003
80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD
Cyp3a62-de11b rat
GenEMBL NW_001084671.1 11932479-11932637
11932637 KKNQDSISPYVYLPFGFRPRNCIGMRFALMNMKVALVRVLQNFSFQPCKEIQL 11932479
Cyp3a63-ps mouse
The following seqs are part of one pseudogene 3a63-ps
GenEMBL NT_045749.1|MmUn_45789_30
3a exon 2 same as 3a63-ps
396 YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK 304
NT_071156.1|MmUn_71196_30
exons 5,6,7 same as 3a63-ps
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
old name = Cyp3a44-se3[10] NW_037585.1|MmUn_WIFeb01_5425
3 diffs to 3a44
same as CYP3A63-ps
649 AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
old temp name = Cyp3attp
80% to 3a11 NW_008810.1|MmUn_WIFeb01_17679
one frameshift and small deletion same as CYP3a63-ps exon 11
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPS
YALHHHWPESEEFQPER
Old name = CYP3A44-se1[12] NW_005077.1|MmUn_WIFeb01_14285
2 diffs with CYP3a44
1231 RFSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ 1067
Cyp3a63-ps AC114427.2
This sequence is between 3a41a and 3a41b
Note: Cyp3a44-de12c has only one aa diff to this seq
63090 MNLFSALSLDTWILLAIILVLLYR 63019 probable beginning of pseudogene
YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK
GFWKFDMECYEKYGKTWG
LFDGQMPLFVITDP*MIKNVLVKECFSVFTNRR
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
HRVDFLQLMMNAHNNSKDKDSHK
AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPSYALHH(fs)HWPESEEFQPER
FSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ
IPLKLSRQGILQPEKPIVLKVVPRDAVITGA
The following sequences are bewtween 3a41a and 3a63-ps
(-)11231 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQV 11067
two sites have exact matches 145849323- 145849487 between 3a41a and 3a63-ps and
146039664- 146039828 between 3a41b and 3a44
3 aa diffs (94%) to Cyp3a-se5[12] probably a poor quality seq match
Cyp3a-se12[8:9:10]
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
IVERTKENCLDSKQK
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31398 SPVQMEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
The following sequences are bewtween 3a63-ps and 3a41b
Cyp3a-se13[9]
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b12b includes old frag w from map
128725 RFSMENKGSIDPY 128763
128769 GPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQV 128876 = Cyp3a-se10[12]
CYP3A64 Macaca mulatta (rhesus monkey)
No accession number
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
CYP3A65 Danio rerio (zebrafish)
No accession number
Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu,
Jun-Lan Wang-Buhler, and Donald R. Buhler
Submitted to nomenclature committee 10/10/2003
71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias,
69% to 3A30 Fundulus, 69% to 3A56 fundulus,
56% to 3A37 chicken, 58% to 3A48 fugu 59% to 3A49 fugu, 45% to 3B2
CYP3A66X Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology = CYP3A5
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A5_2-F5
3 aa diffs to 3A5 Macaca mulatta
CYP3A67 Pan troglodytes (chimpanzee)
No accession
Eric Williams, Henry Strobel
Recent gene duplication of CYP3A7
CYP3A67 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a67
96% to 3A67 chimp
CYP3A68 Large mouth bass
DQ786406
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-a
74% to CYP3A27 trout
MGYFFFFSAETWTLLVALITLIFVYVCWPFGTFKKMGVPGPRPI
PFFGTMLAYKKGFMHFDSECFKKYGKTWGIFDGRQPVLCITDPAMIKTVLIKECYSLF
TNRRNFRLNGELYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLISSM
KKTADKDEPLELKEFFGPYGMDVVTSTAFSVDIDSLNNPTDPFVANIKKMLKFDLFNP
IFLFIAFFPFMAPILEKLEFSFFPKSVLDFFYAALKKIKANRETTKLKNRVDFLQLMI
NSQKNNDLSKVENDKGLNDHEILSQAMIFLFAGYETTSSSLTFLAYNLARNPHVMKRL
QEEVDATFPNKAPVEYQALMQMEYLDSVVNESLRLYPIAPRLERVAKATVEINGLVIP
KGMVVMVPTWPLHRDPDLWPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRF
ALVLMKLAVVEILQTYSFSVCKETEIPIELDIQGLISPKRPIKLKLVPRSEPSN
CYP3A69X Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3A70 Macropus giganteus (Eastern grey kangaroo)
No accession number
Ross McKinnon
Submitted to nomenclature committee Oct. 25, 2004
65% to CYP3A4
NOTE: THIS SEQ IS MOST LIKE RAT 3A9 compared to other rat 3As
Therefore the 3A9 seq may be the oldest of the cluster in rats
3A9 is orthologous to 3a13 in mouse. Both sequences are on the
outside edge of the cluster.
CYP3A71P rat
UCSC Browser chromosome 12
pseudogene 78% to 3A2
9497641 LFEWHTPVFAITDREMIKNVLVKECFSVFTNWR 9497543 exon 4
9468424 DLGPMGIMNKSIAF*KDEEWKRYRALLSPMFTSGKLKV 9468311
9468234 MFPIIKLYGDILVKYLRQEAEKGKPVSVKE 9468145
9467886 IFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKFLRLDYFDPLFISV 9467737
9464756 GLFPFLKPIYDMLNISVFPKDSIAFFKNFVYSMKESHLDSKQK 9464631
9453844 YQVDFFQLMMNAHNNSSESHK 9453782
9451670 FPALSDIEIIAQSIIFTFGGYDTTSSTLSFVLYSLATHSDVQKKLQEEIDHALPNK 9451503
9449744 ASPTYDIVMEMEYLDMVFNETLRLYPVTGRLHRMCKKDIELDGVFIPKG
SMVMIPLYPLQHDPQHWPEPEEFRPE 9449520
9447351 RFSKENKCRTGHYVYLPFGNGPRNCLGMRFALMSMKLAVTKVLQNFSFHPCKET 9447190
9444444 QIPLKLSKQVILKPEKPIVLKVVPRDGVING 9444352
CYP3A72 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
83% to CYP3A28 cow, 78% to 3A5 human, 75% to 3A5,
74% to 3A4, 71% to 3A43
CYP3A73 rat
chr12_random_1.5 (from UCSC browser)
80% to 3A44 81% to 3A41 80% to 3A16 83% to 3A11
86% to 3A2 rat
this gene lies between Cyp3a85-ps and Cyp3a18
MDLVSALSLETWLLLAIILVLFYR (2)
FGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR (0)
GLWKFDMECYKKCGKIWG (2)
LFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR (0)
NIGPVGIMSKSISVAKDEEWKRYRAFLSPTFTSGRLKE (0)
MFPIIEHYGDILVKYLKQKVEKGKPLAMKE (2)
VFGAYSMDVITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSV (1)
VLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHK (0)
HRVDFLQLMMNAHNNSKDKVSHK (1)
ALSDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNK (0)
APPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPER (2)
FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ (0)
IPLKLSRQRLFGPEKPIVLKVVPRDAVITGA*
CYP3A74 Bos taurus (cow)
See cattle page for details
MELILSFSTETWVLLATGLVLLYL (2)
YGTYSYGLFKKLGVPGPRPLPYFGNILSYRK (0)
GVCEFNEECFKKYGKIWG (2)
IFEGKQPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDIKD (2)
IFGAYSMDVITSTSFGVNIDSLGNPQDPFVENVKKLLRFSILDPFLLAV(1)
VLFPFLVPILDVLNITIFPKSAVNFFTKSVKRIKESRLKDNQK(0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPEPEEFRPER (2)
FSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0)
IPLKISSQGVLRPEKPVVLKVVLRDGTISGA*
CYP3A75 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLSISLVLLYL
YGTYSHGLFKKLGVPGPRPLPYFGNVLSYRK
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSV
VLFPFLVPIFEVLNITMFPKSAVNFLAKSVKRIKESRLKDNQK
PRVDFLQLMINSQNSKETDNHK
ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDVTFPNK
APPTYDVLAQMEYLDMVVNETLRMFPITVRLDRLCKKDVKIHGVSIPKGTTVTVPISVLHRDPQLWPEPEEFRPER
FSKKNKDTISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKSCKETQ
IPLKINSQGLIRPEKPIFLKVVLRDETISGA*
CYP3A76 Bos taurus (cow)
See cattle page for details
MELIPNFSVETWVLLAISLVLLYL(2)
YGTYSHGLFKKLGVPGPRPLPLFGNVLSYRK (0)
GVCEFDEECFKKYGKMWG (2)
IFEGKHPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPMGVMKNAVSVAEDEQWKRIRTLLSPTITSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDMKE (2)
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILDPFLLSV (1)
VLFPFLIPIFEVLNISIFPKSAVNFLTTSVKKIKESRLKDTQK (0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAVRLERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPELEEFRLER (2)
FSKKNKDSISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQ (0)
IPLKIKSQGLLRPEKPIFLKVVLRDETISGA*
CYP3A76-ie6b Bos taurus (cow)
See cattle page for details
extra exon 6 SCAFFOLD300381 other exon 6 at 7654
9898 MFPIIGKYGDVLVRNLRKEAEKGKSVNMKE
CYP3A77 Alligator mississippiensis (alligator)
GenEMBL AB186129
Satomi Kohno
Submitted to nomenclature committee Aug. 18, 2005
54% to 3A48 Fugu, 57% to 3A27 trout, 61% to 3A5 human
62% to ball python CYP3A42
clone name CYP3A_AA
CYP3A78 Phascolarctos cinereus (koala, marsupial)
No accession number
Ross McKinnon
Submitted to nomenclature committee July 29, 2005
56% TO 3A4 AND 3A5, 77% TO OPOSSUM 3A (UNNAMED)
CYP3A79 Mediterranean sea bass
GenEMBL DQ268535 not yet available on Jan 4, 2006
Pier Giovanni Gervasi
Submitted to nomenclature committee Dec. 14, 2005
CYP3A80 Gallus gallus (chicken)
GenEMBL XM_414782
Note: chicken has two CYP3As about 25kb apart on chr 14
See CYP3A37
MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPL
PFLGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTF
TNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNI
EKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNP
LLIFIVLFPFMIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMI
DSQSSQDSSKSAREKDSYKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKRLQDEIDANLPNKAAPTYNVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNG
VTIPKDMVVMIPAYVLHRDPAYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCI
GMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHSDP
QN
CYP3A80 Meleagris gallopavo (turkey)
No accession number
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F2
90% to chicken 3A80 probable ortholog
CYP3A80 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80049345-80104701
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mdo1
63% to CYP80A1 chicken (ortholog)
MTSYSGLSTETWTLLVAFVTLLILYGIWPYGIFKKLGIPGPRPLPFFGTFLEYRKGILEFDKQCFQKYGKMWGFYDGRLPIL
AILDPDIIKIVLVKEFYTLFTNRRNFGLNGILDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKV
AQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKMNLSLLSKENI
DFLVNASRRIIADRKKSNSRDRVDFLQLMIDSQVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLA
THPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQKTAEINGITIPKGTVMLIPVYVLHHD
PEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPK
KPIILKLVPRPRPDVED
CYP3A81 Xenopus tropicalis
See Xenopus pages for seq
UCSC Browser scaffold_76:65898-87839 Aug. 2005 (xenTro2) assembly
NM_001015786.1 59% to 3A5 from refseq database
94% to 3A125, 92% to 3A122, 91% to 3A82, 88% to 3A123
MNLIPHLSTGTWILLAALLVLILLYGIWPYGYFKKMGIPGPTPL
PFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNF
TNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNI
QGYVEKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSP
LLILVVIFPFLRPILEGLNLNFVPKDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMM
DSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYETTSTALSYLFYNLATHPDVQQRL
HEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSKQNVEINGVSIP
KGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPFGDGPRNCIGLRF
ALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSRAAAHE
CYP3A82 Xenopus tropicalis
UCSC Browser scaffold_1918:6381-20049 Aug. 2005 (xenTro2) assembly
BX779027 CX415432.1 93% to 3A81 N. Abdletawab
CX415433 = mate pair
Trace archive 243619963 419527443 418746304
476067541 (exon 1)
416306382 joint before I-helix
98% to 3A122 (different scaffold, possible allele), 91% to 3A81,
89% to 3A123, 89% to 3A125
MNLIPHLSTGTWILLAVLLVLILL (2)
YGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR
MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPLESAITVAEDEQWKRIR
SVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDVITSTSFS
VNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFM
NAVTSFREKRKKGDHS (0)
GRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTALSYLF
YNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK
QNVEINGVIIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLPFGDG
PRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSRAAAHE*
CYP3A83 Xenopus tropicalis
CX982440.1 DT453227
UCSC Browser scaffold_320:299565-317579 Aug. 2005 (xenTro2) assembly
60% to 3A80 chicken, 56% to 3A81 57% to 3A82
96% to 3A120, 91% to 3A121, 89% to 3A124
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYKLFKRYGIPGPTPIPFIGTFL
GNRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLS
GPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNKEPLD
MKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVP
LLDKMNFCFLSLKILNFFKDAVASIKKKRQKGTH
EDRVDFLQLMVDAQSNEGKSVPEEEKHGYKE
LSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDA
LMKMEYMDMVINESLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHLNPEIWP
EPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCK
DTPVPLKICTKGYLKPTKPIILNLIPKVGQTVEE*
CYP3A84P dog pseudogene between SDK1 and FOXK1
UCSC browser chr 6
The human pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
are in a syntenic location with this pseudogene
16005702-16005782 (+) strand aa 47-73 exon 1
ISNTCCFLQGFCDFDEKCFRKYARTWG
16125771-16125865 (-) strand aa 74-105 exon 2
IIYRGRQPVLVILGSLLFMRVLVKEFYILFTNR
16124466-16124555 (-) strand 112-141 exon 5
XXXXXXGSLESSLIFAKGDKWNWLRTVISWTFASGK
16119415-16119480 (-) strand 177-198 exon 7
GAFSRDVIISISFGVEADPISN
16044198-16044386 (+) strand 219-277
LFLSTIVFTFPALLLKLLNVIQLPKEGQEFFIGSISKMERKASERNLHSKQGLLVEKRQMFLN
16113643-16113882 (-) strand aa 332-419 exon 11
IQEPLHKCLSLQQAAPTCEVLLQVEYLVTV*MTPSGSTSRGMSGRVWKKT
PEGMLVMITIYRLLRHPMHWLEPEESCPER
Cyp3a85-ps rat
GenEMBL NW_001084671.1 4655562-4666355 (-) strand
86% to 3A2 new gene
(numbering is relative, taken from a larger sequence)
missing first four exons on two different contigs
67133 DLGPLGIMSKAITFSKVEEWKRYRAFLSPTFTSGKLKE 67020
66942 MFPIVEQHGDILVKYLRREDEKGKPAPVKQ 66853
VFGAYSMDEITSTSFGVSVD 66373
66372 FLTNPKDTFVEKTKKLLRFDFFDPLFLSVG
63877 LFPFLTPIYEMLNICMFPKDSIAFLQKFVYRMKETRLDSKHK
62887 HRVDFLQLMLNAHNNSKDEVSHK 62819
60567 ALSDVEIIAQSVTFIFAGYEITSSTLSFVLYSLATYPDIQKKLQEEIDGALPNK 60406
58571 APPTYDIVMEMEYLDMVLNETLRLYPVGNRLERVCKKDIELGGVFIPKGSVV 58416
58415 MIPTYPLQRDPQHWTEPEEFHPER 58344
56749 FSKENKGSIDPYVFLPFGHGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ 56588
53720 IPLKLSIQAILEPEKAIVLKVVPWDAVITGA 53628
CYP3A86 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A87
intestine
CYP3A87 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A86
liver
CYP3A88 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
86% TO 3A22 AND 3A39v1, 76% to human 3A4 and 3A5
partial seq.
CYP3A88 Sus scrofa (miniature pig)
3 aa diffs to CB479861.1 EST, probably the same seq.
F22946.1 extends seq toward N-term.
AJ959509.1 overlaps F22946 with 1 aa diff in 42
Be aware this may be a hybrid of two or more gene sequences.
BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
DB799225.1
92% to 3A39v1
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*
CYP3A89 horse
No accession number
Heather Knych
Submitted to nomenclature committee June 22, 2007
79% to 3A74 cow, 80% to CYP3A4 and CYP3A5 human
80% to CYP3A39v1 pig
CYP3A89 horse
UCSC Browser chrUn:228948991-228982779, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca2
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYHKGIWDFDKKCFEKYGKMWGTYHGTKPVL
AITDPDMIKTVLVKECYSVFTNRRPFGPFGFMKSAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPILGQYGDVLVRNLKKEA
EKGKPITLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLFSFDFLDPLLLSITLFPFLNAVFEVLNVFVFPKSVT
DFFIKSVKRMKESRLKDKEKHRVDFLQLMINSQNSKELDTHKALSDLELVAQSIIFIFAGYETTSSSLSFLMYFLATHPDVQ
QKLQEEIDVTFPNKAPPTYDALVQMEYLDMVLNESLRLFPIAVRLERVCKKDVEINGVFIPKGTVVMVPTFALHKHPEFWPE
PEEFRPERFSKENKDSINPYIYLPFGAGPRNCIGMRFALMNMKLALVRMLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVSGA
CYP3A90 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5a
87% to 3A5 human, paralog of CYP3A5
CYP3A91 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga1
82% to 3A92, 79% to 3A98 dog, 79% to 3A4 human, 78% to 3A5 human
CYP3A92 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga2
82% to 3A5 human, 83% to 3A4 human,
82% to 3A91, 80% to 3A98 dog
CYP3A93 horse
UCSC Browser chrUn:228891415-228923288, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca1
MDLIPSFSTETWVLLATSLVLIYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYRKGIWNFDRKCFKKYGKMWGVYDGRRPVL
AVTDPDMIKTVLVKECYSVFTNRRPFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLMVLFPFLQPIFEVLNISLFPKSAI
DFFTKSVKRMKESRLKDKDKHRVDFLQLMINSQNSKELDTHKGLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQ
QKLQEEIDAIFPNKAPPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFSLHRASEFWPE
PEEFRPERFSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVNGA
CYP3A94 horse
UCSC Browser chrUn:229025212-229061564, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca3
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYLKGFWDFDKKCFKKYGSMWGIYDGPQPVL
AITDPDMIKTVLVKECYSVFTNRRSLGPVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKET
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSITLFPFLKAVFEVIHIYMFPKRVT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQDEIDVTFPNKALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFILHRASEFWPE
PEEFCPERFSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKIGNQGLIQPQKPIVLK
VESRDGTWNGA
CYP3A95 horse
UCSC Browser chrUn:229104699-229137172, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca4
MDLIPSLSMETWVLLATSLVLLYLYGTYSHGHFKKLGIPGPTPLPFFGTVLGYIKGVLAFDKKCFKKYGKMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKPITMKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSILFFPFLIPVYEALNIFVFPKCVT
DFFIKSVKKMKESRLKDKAKQRVDFLQLMINSQNSKEIDNLKVLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQ
QKLQEEIDATFPNKAPPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVLHQHPEFWSE
PEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQIPLKLVSQGLIRPEKPIVLK
VESRDGTMSGA
CYP3A96 horse
UCSC Browser chrUn:229197172-229225636, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca5
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGFDTECLKKYRKMWGFYDGRQPVL
AITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEA
EKGKPIALKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFLFPKSVT
DFFTKSVKRIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQ
QKLQEEIDATFPNMAPPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFALHRDTELWPQ
PEEFHPERFSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQIPLKLVTYGFLQPEKPIVLK
VESRAGTVSGA
CYP3A97 horse
UCSC Browser chrUn:229268263-229304613, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca6
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDFDKKCFKKYGKTWGFYEGRLPVL
AITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAIIRSEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEA
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISVFPKSVT
DFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQKEIDVTFPNKVPPTYDALLQMDYLDMVLNESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPE
PEEFRPERFSKENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTEAIVKPQKPIVLK
VEPRDGTMTGA
CYP3A98 Canis familiaris (dog)
XP_536868.2 GenPept
95% to CYP3A12, 91% to 3A26
MDLIPSFSMETWLLLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGFSVFDENCFRKYGRMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENIKKLLKFDFLDPFFFSILLFPFLTPVFEVLNIWLFPKSVT
DFFTKSVKRMKENRLKDKQKHRVDFLQLMINSQNSKETDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQ
QKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE
PEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLK
VEPRDGSVNGA
CYP3A99 Canis familiaris (dog)
XP_546969.2 GenPept
95% to seq a + f from dog page, (exons 10, 11 do not match)
87% to 3A12, 85% to 3A26
MDLIPSFSTETWLLLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGFCDFDEKCFRKYGRMWGFYDGRQPVL
AIMDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSIILFPFLTPLYEMLNIWLFPKKIT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMNTHKALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQ
QKLQKEIDATFPNKAAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE
PEKFQPERFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILN
VEPRDGSVRGA
CYP3A100 Bos taurus (cattle)
XP_584699.3 GenPept
95% to 3A74, 91% to 3A76, 80% to 3A28
MELIPSFSMETWVLLSISLVLLYLYGTYSHGLFKKLGVPGPRPLPYFGNVLSYRKGVCEFDEECFKKYGKMWGIFEGKHPLL
VITDPDVIKTVLVKECYSVFTNRKVFGPRGIMKNAVSVAEDEQWKRIRTLLSPAFTSGKLKEMFPIIGKYGDVLVRNLRKEA
EKGKSVNMKEVFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSVVLFPFLVPILDVLNITIFPKSAV
NFFTKSVKRIKESRLKDNQKPRVDFLQLMINSQNSKETDNHKALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQ
QKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE
PEEFRPERFSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLK
VVLRDGTISGA
CYP3A101 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80414036-80431004
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo2
89% to CYP3A102, 89% to 3A104, 89% to 3A103, 88% to 3A105, 69% to 3A89
IFTLPYRYGTRTHKLFKNLGIPGPTPLPFIGTVLSYHKGIEGFDYGCFKKYGKTWGFFDGTKPVLAIMDPETIKTVMVKECY
SVFTNRRMLGLSGILEKAISIAEDEQWKRMRTVLSPAFTGGKLKEMFPIIKQYGDVLVKNMKKEAEKSKPVTLKDILGAYSM
DVITSTSFGIHVDSLNNPNDPFVRKIRKLIRFSFRDPLILSIVIFPFLIPLFKKLDITIFSKDVTDFLAKSILKIKEERKKT
EKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYESTSSVLCFLFYQLATNPGIQEKLQKEIDAFLPNKEA
VTYDALVQMEYLDMVINENLRLYPITGRIERIAKKPVELNGLMIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKES
INPYVYLPFGVGPRNCLGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSYRPLLAPSVPIVLQAVLRNKKGNQH
CYP3A102 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80549861-80580975
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo3
90% to 3A104, 89% to 3A103, 89% to 3A105, 89% to 3A101, 80% to 3A106
MNIIPNLSAGTWTLIILFLTILYLYGTRTHKLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVL
AIMDPETIKTVLVKECYSVFTNRRMLGLSGILEKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDAT
DFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLE
IQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYW
PEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIV
LQAVLRNKKGNQH
CYP3A103 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80611887-80640626
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo4
99% to 3A105, 99% to 3A104, 89% to 3A102, 84% tpo 3A106
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A104 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80672879-80701151
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo5
99% to 3A103, 98% to 3A105, 90% to 3A102, 89% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGILEKAISIAEDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERKKSTGKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A105 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80734341-80768989
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo6
99% to 3A103, 98% to 3A104, 89% to 3A102, 88% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A106 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80783381-80814644
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo7 note: this seq has an assembly defect in the middle
85% to 3A105, 84% to 3A103
MNIIPSLSAGTWTLIVVFLTLLYLYGTRTHKLFKNLGIPGPKPLPFFGTVFSYRKGLVNFDYDCFKKYGKTWGFYDGRQPVL
ATMDPETIKTVMVKECYSVFTNRRSFGPVGSLESAITVAKDDQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKNKPVTMKDILGAYSMDVITSTSFGIHVDSLNNPNDPFVREIKKLIRFNFLDPLILSVAIFPFLTPLFNKLDITVFPKDAI
NFLAKSLISMFSTIFSALVFILHYFFQHRVDLLQLMMDSQSSKNSEPHSHKDLSDQEILAQSIIFLFAGYETTSSVLSFLFY
HLATNPEIQEKLHKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLFPIAGRVERVAKKTVELNGLTIPKGTVVMTPPYVL
HREPEYWPEPEKFHPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMNMKVAVSRLLQEFSFRTCKETQVPLKLGNQPIL
TPTIPIVLQAELRNKKTN
CYP3A107 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25769723-25784944, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan1
78% to CYP3A108, 75% to CYP3A109, 71% to CYP3A110, 57% to CYP3A113
MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGKIWRLFEGRQAMV
AVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSGKLKEMLRIMIHYGEILVKTIWKKA
EKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKLSSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSV
EYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQNPKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDV
QQKLQEEIDKVLPNKSPLTYDAIVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWT
EPDEFRPERFSKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPIVL
QFIPRADTKSQD
CYP3A108 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25741772-25760791, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan2
79% to 3A109, 78% to 3A107, 75% to CYP3A110, 56% to 3A37 chicken
MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGKIWGLYEGRQAII
AVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSGKLKEMLPIMTHYGEVLVRNIWRKA
EKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKISSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSV
EYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQNPKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDV
QEKLQAEIDTVLPNKSPLTYDALVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWL
EPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPIVL
RYIPRADTKIKD
CYP3A109 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25693551-25724066, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan3
79% to 3A108, 75% to 3A107, 77% to 3A110, 55% to CYP3A37 chicken
MSSILSFSIETWILLGTFLALMILYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKI
AVLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYGEVLVKNLQNKV
EKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALISVLPFMIPLLKLLNINTFPNDSV
EYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDV
QKKLQEEIDEVLPNKAPLTYDALVQMEYLDMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWV
NPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVL
RFIPRAEIKSKD
CYP3A110 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25660643-25688288, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan4
77% to CYP3A109, 75% to 3A108, 71% to 3A107, 56% to 3A37 chicken
MRGILNFSIETWILLGSFLTLVILYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFDKKCFQKYGKIWGFYEGWKAKI
AVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRTLISSTFTSGKLKEMVPTIIHYGEILVKNIWYKA
EKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDRFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSV
EYFKRFMDNIKGTHHQGNQQQQVNFLQMMLDTQNPKEGSKAKGVLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDV
QQKLQEEIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHREPKYWL
EPDEFHPEIPLELTARGFLIPQKPIVLQFIPRAEIKKG
CYP3A111 Ornithorhynchus anatinus (platupus)
UCSC Browser, Contig7638:3143-20297, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan5
66% to CYP3A80 opossum (possible ortholog),
63% to 3A113, 60% to 3A80 chicken
GGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDI
DSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVDFLQLM
VDSQSSDSNSEPKMTDTEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDM
VVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPR
NCIGMRFALLNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED
CYP3A112 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:62196-70979,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca1
84% to CYP3A113, 69% to CYP3A114, 66% to 3A80 chicken
62% to CYP3A80 Monodelphis domestica, 60% to 3A37 chick
MDFFSFFSIQTWSLLGIFLLLLMLYGIWPYNFFKKLGIPGPRPLPFIGTFLEYNKGVLDFDERCRQKYGKIWGFFDGRQPVM
AIMDPVIIKTILVKECYTHFTNRRDFGLNGDFDASVLVAQDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGEMLVKNVQKKG
ENGEYIDTKDIFGAYSMDVITSTSFSIDIDSINNPKDPFVVSMKKIIKTNFVNPLLLLIVIFPFLRPVLEALNISLAPTSAT
GFLRGALRKIKSDRQKNVHQDRVDFLQLMVDSQISGDVFDGTNSYKALNDREILAQAFTFVFGGYETTSSTLGYMAYCLATH
PDVQKKLQDEIDEVLPDQATPVYDALLQMEYLDMVINETLRLYPPGGRIERVCKNTVEINGVTIPKGTVAMIPAFVLHRDPE
FWPEPEEFRPERFSKENKEFLNPYVFLPFGIGPRNCIGMRFALLSLKVATVVLMQRFSFRTCKETPIPLELESKGFMRPKNP
IRLKFVPRVMAESNE
CYP3A113 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:49268-57033,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca2 Browser is missing first exon in a seq gap
84% to CYP3A112, 68% to 3A80 chicken, 72% to 3A114
61% to 3A37 chick
GIWPYNFFKKLGIPGPRPLPFIGTFLEYRKGVLDFDEMCHKKYGKIWGFFDGREPVMAILDPVIIKTILVKECYTHFTNRRD
FGLNGDFDSSILTVQDEQWKRIRTVLSPNFTSGRLKEMFPIINHYGEMLVKNIQKKVENGEYIDTKDIFGAYSMDVITSTSF
SIDIDSINNPNDPFVTNIKKIVKFNFVNPLLVLIVIFPFLTPVLEALNFSLTPTSVTNFIKESIKKLKKDRQKNLHKDRVDF
LQLMVDSQISGEILDDSKSYKALNDKEILTQAIIFVFAGYETTSSTLSYMAYCLATHPDVQQKLQEEIDEALPNQATPVYEV
LLQMEYLDMVINETLRLYPPGGRIERVCKTTVEINGVTIPKGTVTMIPAFVLHRDPEFWPEPEEFRPERFSKENKETLDPYT
FLPFGAGPRNCIGMRFALLSLKVAMIVLLQRFSFRTCEETPIPLELQSQGFMTPKKPIRLKFVPRVMAESKE
CYP3A114 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:33297-45513,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca3
72% to CYP3A113, 69% to 3A112, 61% to 3A80 chicken
58% to 3A37 chick
YGIWPYNFFKKLGIPGPRPLPFIGTLHKHRIGVNNFDQKSHEKYGKIWGLFDGRQPVIAILDPAIIKIILVKHFYTHFTNRR
DFGLNGELDTSIAITRDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGKILVESAQKKVENGEAIDLKSFFGGYSMDVTTSTS
FSINVDSINNPNDPFVMHIKTFLKFDTFDPVILLVVIFPFLRPLFERLNFNMVAPSSFTTFFIDVLKKVKKDRQKNDHKNRV
DFLQLMVDSQISGNIPEEAKMYKALTDKEILTQAIVFIFAGFETTSTTLSFLSHCLATNPDVQQKLQEEIDATLPDQATPTY
NAIQQMEYLDMVVNETLRLYPVGGRIERDCKNTVEINGVTIPKGTVIVIPTFPLHRDPEYWPEPEEFRPERFSKENKETQNP
YVYLPFGAGPRNCIGMRFALLVVKVAIVVLLQKHTLRPCKETQIPLEVHGQVLLEPKKTIKLKLVRRAGLEE
CYP3A115 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:424-21366,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca5 partial seq
54% to 3A37 chicken
YGIWPYGVFKKLGVPGPTPLPFIGTALAYRNGILQFDKACFKKYGKVWGFYDGRTPVLAVTDPAVIKAVLVKECYTVFTNRR
KFGPTGKLEKAVSLAEDDTWKRIRTVLSPTFTSGKLKEMLPIIQHYAEILIKNFSEKADKGETVDIKDVLGPYSMDVVASSS
FGVNINSMNNPQDPFVKQAKKLVKFNFFSPLFVLMYMVPWLTPVLNKMNITLFSAEAVDFFAKAIGKIKEQRKQEMDKGRVD
FLALMIESQKAEAKTQINGMNQTYKFSKENKGRIDPYVYLPFGAGPRNCIGMRFAFLILKAGAVSLLQNFTFKPCKETQIPM
ELSTTGLMIPKKPIILKAIPRASSSH
CYP3A116 Dicentrarchus labrax (European sea bass)
ABB90404.1 GenPept
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Dla3aX
Possible Ortholog of CYP3A68
87% to 3A68 bass
MGYFFYFSAETWTLLVTLITLFFVYVYWPYGTFKKMGIPGPKPIPFFGTMLAYRKGFMNFDSECFQKYGKTWGIYDGRQPVL
CITDVSMIKTVLIKECYSLFTNRRNFRLNGPLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFGIMKQHSANLISSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDLDSLNNPSDPFVTNIKKMLKFDLFSPLFLIVAFFPFMGPVFEKMEFSFFPTYVT
DFFYAALQKIKSNRETSKQKSRVDFLQLMIDSQKNNDLSGVEQDKGLNDHEILSQAMIFIFAGYETSSSSLTFLAYNLATNP
AVMKRLQQEIDSTFPNKAPIEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVELNGIVIPKDMVVMIPTWPLHRDPDL
WPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRFALVMMKLAIVEVLQRYSFSVCKETEVPFEMDIQGLLMPKRPI
KLKLEPRSEPSS
CYP3A117 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4870920-4874088, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33062
Paralog of CYP3A68
93% to 3A119, 93% to 3A118, 81% to 3A68 bass,
81% to 3A68 Dicentrarchus
MGFSLFLSAETWTLLVALVTLLFMYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFEGRQPVL
CITDPAMIKTILIKECYSLFTNRRNTRLNGQLHDALTVAENHQWRRIRSVLSPSFTSGKLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKLLNIDFFSPVFLIVAFFPFLGPIMEKMEFSLFPKSVT
DFFYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIVPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSL
WPEPEAFKPERFSKENKDSIDHYTYMPFGAGPRNCIGMRFALMMMKLAMVEILQRFSLSVCKETEIPLEMDTQAVVMPKRPI
KLKLVSR
CYP3A118 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4859354-4863677, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33063
Paralog of CYP3A68
95% to 3A119, 93% to 3A117, 83% to 3A68 bass
MGFSLFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGIPGPQPIPFFGTMLAYRKGITTFDEDCSKKYGKVWGIFDGRQPVL
CITDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDILSPLFLIVAFFPFLGPIMEKMEFSFFPKSVT
DFFYSALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIILRLERVAKATVEINGIVIPKDMVVAVPTWPLHRDPSL
WPDPEAFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVENLQRFSFSVCKETEIPLEMDVQDLLMPKRPI
KLKLVSR
CYP3A119 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4853058-4857963, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33064
Paralog of CYP3A68
95% to 3A118, 93% to 3A117, 87% to 3A68 bass,
86% to 3A68 Dicentrarchus
MGFFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFDGRQPVLCI
TDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKADK
DEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDFFSPVFLIVAFFPFMAPILEKMEFSFFPKSVTDF
FYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSSLSFLAYNLARNPHI
MKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSLWP
EPEAFKPERFSKENKDSIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVEILQRFSFSVCKETEIPLEMDVQGLLMPKRPIKL
KLVPR
CYP3A120 Xenopus tropicalis
UCSC Browser scaffold_320:325056-341660, Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3202
96% identical to CYP3A83, adjacent on chr, 90% to 3A121
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRKGLMEFDMECFKKYGKVWGIYEGQKPLL
AIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEKHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNI
ATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKP
TKPIILNLIPKAGQTVEE
CYP3A121 Xenopus tropicalis
UCSC Browser scaffold_320:348830-370189 Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3203 adjacent to CYP3A120, 91% to 3A83, 90% to 3A120, 88% to 3A124
MTFLPDFSKETWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRHGLMEFDMKCFKKYGNVWGFYDGPQPVL
AILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKMNFCFLSSKFL
KFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEEKHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNI
ARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKP
TKPIILNLVPKGAQTTEEQI
CYP3A122 Xenopus tropicalis
UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
98% to 3A82 (different scaffold, but possible allele)
92% to 3A81, 90% to 3A123, 90% to 3A125
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE
CYP3A123 Xenopus laevis
AAH60496.1 GenPept
90% to 3A122, 90% to 3A125, 89% to 3A82, 88% to CYP3A81
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE
CYP3A124 Xenopus laevis
AAH84827.1 GenPept
89% to 3A83, 89% to 3A120, 88% to 3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE
CYP3A125 Xenopus laevis
AAI29607.1 GenPept
94% to CYP3A81 (possible ortholog),
90% to 3A123, 90% to 3A122, 89% to 3A82
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE
CYP3A126 Pimephales promelas (Fathead minnow)
No accession number
Roger Meier
Submitted to nomenclature committee Dec. 29, 2007
81% to CYP3A65 Danio
CYP3A-se1[2] human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
old name = CYP3A54P
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A-se2[5] human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
old name = CYP3A55P
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
mouse Cyp3a fragments of uncertain location
Cyp3a-se3[1] mouse
NT_039319.1
new 3a frag from 1-24 exon 1 + strand
v in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
The true location of this fragment is uncertain
14293 MEPV (frameshift) FSSLTGYEWILLAIILVLLYR 14358
Cyp3a-se4[5:6]X mouse
NT_071157.1|MmUn_71197_30
3a exons 5,6, only 3 aa diffs with 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
95% to 3a63-ps
549 EFGSVAIMSKAISISKDEECKRYRALLSPTFTSGRLKE 436
356 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 267
Cyp3a-se5[12]X mouse
NT_071987.1|MmUn_72027_30 3a exon 12
2kb genomic sequence near exon 12 has best match to 3a41a-de12b
The fragment was removed from Genbank
This was probably a poor quality version of 3a41a-de12b
12194 FIKESKGNIHPYIYLPFGNGPRN*IGMRFALLNMKLTLTKVLQNFTFQPCKETQ 12033
Cyp3a-se6[12] mouse
NT_055698.1|MmUn_55738_30 3a exon 12
5 aa diffs with 3a58-ps
identical to 3a11-de9b10b11b12b
may be the same sequence between 3a44 and 3a11
1226 FSMENKGSIDPYX 1191
1186 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQ 1064
Cyp3a-se7[8:9:10]X mouse
NT_067897.1|MmUn_67937_30 3a exon 8
NT_059425.1|MmUn_59465_30 3a exon 10
5160 bp of the genomic sequence was 98.9% to 3a-se12[8:9:10] pseudogene region
The fragment was removed from Genbank. This was probably a poor quality version of
3a-se12[8:9:10]
5042 FATFFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 4935
4933 IVERTKENCLDSKQK 4889
HQVDFLHLMINAHDNTKDNESHK
979 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLTHHDS*KNLRENDRALPNK 821
Cyp3a-se8[3]X mouse
NT_070793.1|MmUn_70833_30
1 diff to 3a11 exon 3 or 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
671 GFWKFDMECYKKYGKTWG 618
Cyp3a-se9[8]X mouse
NT_050947.1|MmUn_50987_30
2 diffs to 3a41 exon 9
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
174 HRVDFLQLMMNAHNNSKDKNSHQ 106
Cyp3a-se10[12] mouse
NT_050917.1|MmUn_50957_30
3a exon 12, 3aa diffs to 3a58-ps
521 FSMENKGSIDPYXXXXXX 486
483 NGPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQ 377
Cyp3a-se11[2]X mouse
NT_074310.1|MmUn_74350_30 3a exon 12
2 diffs to 3a16, 3a41 3a44, 3a63
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
1107 YGTLTQGLFKKQGIPGPKPLPFLGTVLNYYK 1199
Cyp3a-se12[8:9:10] mouse
NT_056284.1|MmUn_56324_30
3a exon 10
revised to add two more exons 8 and 9
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31410 MEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
Cyp3a-se13[9] mouse
Between 3a63-ps and 3a41b in UCSC browser
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b and old frag w from map
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A sheep
PIR A60728 (20 amino acids)
Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
Purification of a sheep liver cytochrome P-450 from the
P450IIIA gene subfamily. Its contribution to the
N-dealkylation of veterinary drugs.
Biochem. Pharmacol. 39, 901-909 (1990)
only one amino acid difference with CYP3A24 (L9K)
CYP3A baboon (Papio sp.)
Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
Purification of two cytochrome P450 isozymes related to CYP2A
and CYP3A gene families from monkey (baboon, Papio papio)
liver microsomes. Cross reactivity with human forms.
Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
Eur. J. Biochem. 204, 641-648 (1992)
CYP3B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213a
6382 MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232 YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052 GIIPFESWCQAEYGDVWG 5999 (2)
Exon 3 not detected may be in small seq. gap
5469 XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259 AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069 FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846 AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011 GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780 APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651 LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416 FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171 IPLEFDWKSQPLKPIKLSFIPRQK* 3097
CYP3B2 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
8214 HKDPRFWSSPEEFRPER 8164 (2)
XXXXXXXXX in sequence gap
IELGTFMX frameshift
8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734
CYP3B3 Oryzias latipes (medaka)
UCSC Browser, chr15:14900678-14906425, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola1
70% to 3B4, 67% to 3B7, 66% to 3B6, 67% to 3B1
MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNLNIPGPKPLPFVGTIFGVRKGLFAFDSECQAKYGDVWGLYDGRSPVLM
VADPEMIKTIMVKECYSVFTNRRETLIPGPFEDGITVVKDDRWKRIRSTISPCFTSGRLKQVFPIVASYADRLLKKLEQTNL
DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSEDPVNVHIQKLFNINFWPFILLMICPFAGRLLNSLNIGMLPKAESDFFL
NIIKKFKDQHKAGESTRQDFLQVMVQSEIPENEIKNEQEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHA
MHTLQKEIDANLQKNASFSYEELNDLHYLDQVILESMRVLPTAPRLERGCKKTVEIQGFTIPEGTVVGIPVMNLHKDPRYWS
SPELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLETCKDTLIPLQFDWKFQPLKPIKLKF
VPRKQ
CYP3B4 Oryzias latipes (medaka)
UCSC Browser, chr15:14910843-14918605, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola2
69% to 3B6, 70% to 3B3, 68% to 3B5, 66% to 3B7, 64% to 3B1
MFWSWFPGATWTLLALLLTILIFYGLWPYRVFKNLGISGPMPLPFVGTVPQQMKGLFAFNRECQAKYGDVWGLYEGRSPLLM
IADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMN
LNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWPMIIRMIFPLGARLLKHFKFEIIPRSSVDFF
CDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESEVKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPD
AMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQINGLTIPEGTVVGIPVHLLHRDPRFW
DSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWKFQPLKPIKLK
FVPRKR
CYP3B5 Oryzias latipes (medaka)
UCSC Browser, chr15:14921023-14926010, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola3
71% to 3B6, 68% to 3B4, 66% to 3B3, 62% to 3B7, 59% to 3B1
MLFLFSATTWTLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQQGKGFFEFDHECQTKYGDVWGVFEGRQPILMV
ADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVASAKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYL
NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQKATRFNFLPTILQSIIPFGGRLLKLFKIETLPSANVEFFI
DIIRNLKDQHKTENRPDFLQVLIESEMPDAEIKNSQQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMH
TLQKEIDSNLQKNSSISYEDLNGLEYLDQVINESLRLYPVAPRLDRECKMTVETQGFTVPEGMIVGIPVYLLHKDPRFWSSP
ELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQFNWMFQPIKPVKLKFVP
K
CYP3B6 Oryzias latipes (medaka)
UCSC Browser, chr15:14927785-14936321, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola4
69% to 3B4, 71% to 3B5, 66 to 3B3, 65^ to 3B7, 61% to 3B1
MFSATTWTLLALFFTVLLLYGVWPYRVFRKLGISGPMPLPFVGNVLQMGRDILSFDRQCLDKYGDVWGVFEGRQPMLMVANP
ELVKAVMVKECYSAFTNRRNFFPEDGPLADGVAVVKDEKWKRIRSSLTPCFTSGRLKQVYPLVARYAENLVKKLGRMNSDEP
IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPVNVQAQKATNFNFWPVILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLI
KRLRDQHKAGKLTRPDFLQVLIDSEIPQEHVKNEQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQ
KEIDSNLQNDGSFSYEELSGLEYLDQVLCESMRFFSPTPRLDRECKKTIEIHGVTIPKGTLVAIPVSLLHMDPRFWSSPEIF
RPERFSKENASELNPYAYMPFGLGPRNCVGMRFAVLVMKMVIVRLLQSYSLETCKDTLIPMQYDWQFQPIKPIKLKFVPRKQ
CYP3B7 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrVI:13967807-13971259, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac49971
68% to 3B1, 66% to 3B4
MFLFDWFPATSWTLLALFFTLLILYGIWPYRFFKNLGIKGPRPLPFIGTFLHFRKGWLSFDRECQAKYGDVWGNFDARLPVL
MVADPEIIKTVMVKECYSVFTNRRENAVPGPMGDAITAVKDERWKRIRTSLSPCFTSGRMKQVFPIVARYADRLTEKLGGMH
SVPIDVKQFMAPYSLDVVTSASFSVEANSINNPDDPLNVHLKNILNFKLWPVFILMVFPFGARLLRLLKLEMLDRVSVDYFY
DVIKHFKHQHGEDESTRADFLQVMIQNEIPDTDIKSEEDQPSKGLTEHEILSQALIFIFGGYETTSTTLTFLLYNLATNPDA
MRTLQEEIDANIPRDAPIRYEDLLGLQYLDQVLLESQRLIPTAPRLERVCKKTTQVHGLTIPKDTLVGIPVQLLHMDPRFWS
SPELFRPERFSKESGEEVNPYAYMPFGLGPRNCVGMRYAVLTMKTVLVRLLQSYNVETCKDTMIPLEFDWKAQPVQPVKLQF
VPREQ
CYP3C1 Danio rerio (zebrafish)
GenEMBL BC052130.1 dated 10/7/2003
Also submitted by Don Buhler 10/2/2003
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T,
Chung WG, Buhler DR. CYP3C1, the first member of a new cytochrome
P450 subfamily found in zebrafish (Danio rerio).
Biochem Biophys Res Commun. 2006 Feb 24;340(4):1039-46.
52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49
53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout,
54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken,
48% to 3A29 pig (47% to 50% to many mammal 3As)
CYP3D1 Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Formerly CYP3A47
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQGASP (1)
RCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3D1 Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
Formerly CYP3A69
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3D1 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4874663-4879489, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33061
76% to 3D1 bass (ortholog), 61% to 3D1 Fugu,
58% to CYP3A119, 57% to 3A68 bass
MGCLPFFSVETWILLITFICIFVIYGNWTHGIFENLGIPGPKPYTYWGTIGRHNKVYYKDDQQCAEKYGKVWGMYEFRSPML
AVMDPDMLKTILVKQCFTYFTNRRNIRLNGDLYDSVSTVEDDHWRRIRNVLTPSFTSGHIKEMFKIMKHLSSKLTASLQSKA
QNNEVVTIKDYFGAYSVDVMASCAFSVDMDSINNHSSPIIFHASRFFKFPQFVLILQGIFPVLIPLFELLGISFFSPTSTAF
FKTILAKIKAEREGSTHKNSGDFLQSMINSRTANDPSKGEKNKGSLTDHEILTQATMFMVAGYETSATTLAFLAYNLARNPE
VMKRLQEEIDSTFPNKGAVRYEELLQMEYLDSVVNESMRLYPPAGRLDRVAKKTVEIRGITIPKDMIVMIPVYALHRDPDLW
PEPEEFKPDRFSKQNKRSINPYTYLPFGTGPRNCLGMRFALVLVKLALVEVLQNYSFSVCGETEIPLTMDPGGLVGPLNPIK
LKVTTR
CYP3E1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CK326870.1, CF075781
David Drane
3clan 38% CYP3A22 pig
N-term only
MWLAWLIGIVTALS
AYYIIAARRKFEYWQKKGVPGPRPWPLVGVFVQTVRMGQGFYDVWATKQFGRMFGYFDGS
QPVIAVSDPEMLRSIMVKDFPQFINRRDVDINGPLLEQAVSVLHGQKWKDVRSTLVPTFT
SGRLKQMNGLINECCDNLVSNLEKKADADEEFECQSLFRSVTMDVIASTFFG
4A Subfamily
CYP4A1 rat
PIR S21711 (22 amino acids)
Okita, R.T. and Okita, J.R.
Characterization of a cytochrome P450 from Di(2-ethylhexyl)
phthalate-treated rats which hydroxylates fatty acids.
Arch. Biochem. Biophys. 294, 475-481 (1992)
CYP4A1 rat
Aldridge et al.
Biochem. J. 306, 473-479 (1995)
note: identification of far upstream PPAR response element.
CYP4A1 rat
GenEMBL M14972
Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
Isolation, complementary DNA sequence, and regulation of rat
hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
Identification of a new cytochrome P-450 gene family
J. Biol. Chem. 262, 801-810 (1987)
CYP4A1 rat
GenEMBL X07259
Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
Differential splicing in the 3' non-coding region of rat cytochrome
P-452 (P450 IVA1) mRNA
FEBS Lett. 236 (2), 357-361 (1988)
CYP4A1 rat
GenEMBL M33937 M57718
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A2 rat
GenEMBL M33938 M57719
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A3 rat
GenEMBL M33936
Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
coordinate and tissue-specific regulation of the CYP4A genes
DNA 8, 517-525 (1989)
CYP4A4 rabbit
GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
PIR S32423 (64 amino acids)
Palmer,C.N., Griffin,K.J. and Johnson,E.F.
Rabbit prostaglandin omega-hydroxylase (CYP4A4):
Gene structure and expression.
Arch. Biochem. Biophys. 300, 670-676 (1993)
Note: The translation is different from the 4A4 sequence
in the alignment after AALLG. A frameshift occurs between
nucleotides 1201 and 1203, with an extra "G" added. After 1320
P450 similarity stops. 1320-1378 is an intron sequence.
CYP4A4 rabbit
PIR JN0089 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A4 rabbit
GenEMBL J02818
Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
and Kusunose,M.
cDNA cloning and inducible expression during pregnancy of the mRNA
for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
P-450p-2)
J. Biol. Chem. 262, 13366-13371 (1987)
CYP4A5 rabbit
GenEMBL M28655
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A5 rabbit
GenEMBL X57209
Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning and expression of the mRNA for cytochrome P-450kd
which shows a fatty acid omega-hydroxylating activity
Eur. J. Biochem. 196 (3), 531-536 (1991)
CYP4A6 rabbit
PIR S23949 (510 amino acids)
Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
Characterization of a rabbit gene encoding a
clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A6 rabbit
PIR PQ0047 (20 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
CYP4A6 rabbit
GenEMBL M29531 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A6 rabbit
GenEMBL M28656
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A6 rabbit
GenEMBL L04755
Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
Characterization of a rabbit gene encoding a clofibrate-inducible
fatty acid omega-hydroxylase: CYP4A6
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A7 rabbit
PIR JN0090 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A7 rabbit
GenEMBL M29530 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A7 rabbit
GenEMBL M28657
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A8 rat
PIR S08300 (15 amino acids)
Imaoka, S., Nagashima, K. and Funae, Y.
Characterization of three cytochrome P450s purified from
renal microsomes of untreated male rats and comparison with
human renal cytochrome P450.
Arch. Biochem. Biophys. 276, 473-480 (1990)
CYP4A8v1 rat
GenEMBL M37828
Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
Cloning and characterization of a novel member of the cytochrome
P450 subfamily IVA in rat prostate
DNA Cell Biol. 9 (8), 569-577 (1990)
CYP4A8v2 rat
UCSC browser
This is the best match to M37828, but there are some differences
especially in exon 6 (9aa diffs)
97% TO 4A8v1 M37828 chr5:135553023-135583411 (- strand) BC081771
CK483390.1 AGENCOURT EST matches
135583411 MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHK 135583223 (0)
135581811 IPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS 135581671 (1)
135581054 DPKSHHSYRFLAPWI 135581010 (1)
135580577 GYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIML 135580449 (0)
135558913 DKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDR 135558788 (2)
135558475 KYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 135558323 (1)
135557899 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135557792 (0)
135557703 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135557512 (2)
135557411 DDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK 135557280 (1)
135556361 GITVMLSFYGLHHNPTVWPNPE 135556296 (0)
135556143 VFDPYRFAPESSRHSHSFLPFSGGAR 135556066 (2)
135553187 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ 135553023
CYP4A8v2-de1b rat
UCSC browser
CYP4A exon 1 pseudogene chr5:135545150-135545338 (- strand)
Frag a in fig. below
135545338 MSIFELSHITTGFGISGLLQMVSWLGLLLLLLFKAAQYYLHRQWIIKSVQHFPSPPSHWFFGN 135545150
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de5c6c12c rat
UCSC browser (upper line is the new sequence)
135596695-135596537 (- strand) C exon 5
Frag b in fig. below
Query: 37481 SVLLPQNKWE*TISDS---LEIFQCASLITLATILMCVFSY*DNVHLNRSVTSQSF 37639
SV + +KWE + D LEIF SL+TL T++ C FS+ +V L+ V S+S+
Sbjct: 159 SVSIMLDKWE-KLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 211
135596212-135596066 (- strand) D exon 6
Query: 37964 HSQTYTQVVGILNNL-----RNAFPQSDIFYRMTADGHRTKNAFLIAHKHSDFV 38110
+S++YT+ V LNNL R+AF + I Y M++DG ++ A IAH+H+D V
Sbjct: 207 NSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 260
135594009-135593884 (- strand) E exon 12
Query: 40167 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 40292
KQF MNE+KV + LTLL FE L DPTR+ V + +L + G
Sbjct: 454 KQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNG 495
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de4d12d rat
UCSC browser (upper line is the new sequence)
135628319-135628215 (- strand) A exon 4
51% to 4A8
Frag c in fig. below
Query: 5857 LSNDQTWFQHY*HI*TPLLHCDILKSNVRIVADCI 5961
L N + WFQH + TP H DILK V+I+AD +
Sbjct: 127 LLNGKKWFQHR-RMLTPAFHYDILKPYVKIMADSV 160
135617441-135617274 (- strand) B exon 12
75% to 4A2 76% to 4A8
Query: 16735 RICIGKQLAMNAQKLAVALTLLQFELLPDPTRVPIPTEKLVLKSKNGIHLHLRKLQ 16902
R CIGKQ AMN K+AVALTLL+FELLPDPTR+P+P +LVLKSKNGIHL L+KL+
Sbjct: 449 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR 504
human, mouse and rat 4ABXZ clusters
Cyp4a10 mouse
GenEMBL X69296 (1887bp)
Colin J. Henderson, Theo Bammler & C. Roland Wolf
Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a
protein: developmental and hormonal regulation in liver and kidney
Biochim. Biophys. Acta (1994) 1200, 182-190
Cyp4a10 mouse
GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
GenEMBL Y10221 (exons 10-12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a10 mouse
GenEMBL AB018421
Yasumura,N. and Ikeda,T.
Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
Unpublished (1998)
Cyp4a10 mouse