P450s that have appeared since the 1993 P450 nomenclature update.
This is Part B of the P450 bibiographic files.
Sequences covered are CYP3 to CYP9.
This list now includes all Drosophila P450s
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list.
Added 4A23-4A25, 6X1 9J1, 9J2,
4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2
Added all human genes and pseudogenes
Added CYP8B1 pig
Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
Added 25 Aedes and 104 Anopheles sequences
Added CYP9G2
This list was last revised on April 7, 2003.
Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
July 2, 2003 added 4F42, 3A64, 4T6, 4T7
Last revised Aug 19 2003, added 9A12
Last revised Sept 26, 2003 added accessions for some old seqs.
Last revised July 8, 2004 added Anopheles funestus CYP9s
Last revised Jan. 31, 2005 added Anopheles funestus CYP6s and 4C25
Last revised March 17, 2005 added Anopheles funestus CYP9L4 and 9K1
Last revised June 24, 2005
Last revised Jan. 4, 2006
Last revised Dec. 31, 2007
3A Subfamily
3B Subfamily
3C Subfamily
3D Subfamily
4A Subfamily
4B Subfamily
4C Subfamily
4D Subfamily
4E Subfamily
4F Subfamily
4G Subfamily
4H Subfamily
4J Subfamily
4K Subfamily
4L Subfamily
4M Subfamily
4N Subfamily
4P Subfamily
4Q Subfamily
4R Subfamily
4S Subfamily
4T Subfamily
4U Subfamily
4V Subfamily
4W Subfamily
4X Subfamily
4Y Subfamily
4Z Subfamily
4AA Subfamily more CYP4 subfamilies follow
5A Subfamily
6A Subfamily
6B Subfamily
6C Subfamily
6D Subfamily
6E Subfamily
6F Subfamily more CYP6 subfamilies follow
7A Subfamily
7B Subfamily
8A Subfamily
8B Subfamily
9A Subfamily
9B Subfamily
9C Subfamily more CYP9 subfamilies follow
3A Subfamily
CYP3A1 rat
GenEMBL D13912 (2023bp)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of steroid-
induced cytochrome P450 3A in rats
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: only 11 differences and two missing amino acids with
3A1. All changes are limited to a 113 amino
acid region, M10161 probably represents a hybrid seq. with Cyp3a2.
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S30378 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL L24207 (2015bp)
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
Unpublished (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of
steroid-induced cytochrome P450 3A1 in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL M28452 (897bp)
Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
Demonstration in multiple species of inducible hepatic cytochromes
P-450 and their mRNAs related to the glucocorticoid-inducible
cytochrome P-450 of the rat
Mol. Pharmacol. 28, 312-321 (1985)
Komori,M. and Oda,Y.
PIR JX0334 (502 amino acids)
A major glucocorticoid-inducible P450 in rat liver is not 3A1.
J. Biochem. 116, 114-120 (1994)
Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S36137 (30 amino acids)
Ribeiro, V. and Lechner, M.C.
Cloning and characterization of a novel CYP3A1 allelic
variant: Analysis of CYP3A1 and CYP3A2
sex-hormone-dependent expression reveals that the CYP3A2
gene is regulated by testosterone.
Arch. Biochem. Biophys. 293, 147-152 (1992)
This sequence agrees exactly with PIR JX0334, a 3A1 variant
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S27107 (24 amino acids)
PIR S21697 (504 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A2 rat
GenEMBL M74443 (4230bp) U09725 to U09734 13 exons
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
U09725-U09734 report corrections to M74443
CYP3A2 rat
Gen EMBL X79319 (8014bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL U09742 (1936bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2:
Comparison of the cDNA with P450PCN2.
unpublished (1994)
CYP3A2 rat
Yamazoe,Y. et al.
Transcriptional elements directing a liver-specific expression of
P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
Arch Biochem Biophys. 318, 71-79 (1995)
CYP3A2 rat
PIR S30379 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
CYP3A2 rat
GenEMBL S45634 (1572bp)
PIR S27108 (36 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
CYP3A2 rat
UCSC Browser chromosome 12
9570862 MDLLSALTLETWVLLAVILVL 9570800
9570429 LYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK 9570328
9566707 GLGRFDMECYKKYGKIWG 9566654
9564529 LFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR 9564431
9559660 DFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKE 9559547
9559467 MFPIIEQYGDILVKYLKQEAETGKPVTMKK 9559378
9559082 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSV 9558936
9556537 VLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHK 9556409
9555511 HRVDFLQLMLNAHNNSKDEVSHK 9555443
ALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK in a seq gap
9551883 APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG
SVVTIPTYALHHDPQHWPKPEEFHPE 9551659
9550394 RFSKENKGSIHPYVYLPFGNGPRNCIDMRFALMNMKLALTKVLQNFSFQPCKETQ 9550230
9547469 IPLKLSRQAILEPEKPIVLKVLPRDAVINGA 9547377
CYP3A3X human
PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
Complete cDNA sequence of a cytochrome P-450 inducible by
glucocorticoids in human liver.
Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
This number is discontinued the seq = CYP3A4
CYP3A4 human
GenEMBL D11131 (1345bp)
Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
Kamataki,T. and Itoh, S.
Gene structure of CYP3A4 an adult-specific form of cytochrome
P450 in human
livers and its transcriptional control.
Eur. J. Biochem. 218, 585-595 (1993)
CYP3A4 human
GenEMBL J04449 (2849bp)
Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and
Guengerich,F.P.
Characterization of mRNA species related to human liver cytochrome
P-450 nifedipine oxidase and the regulation of catalytic activity.
J. Biol. Chem. 264, 910-919 (1989)
nf-10 nifedipine oxidase (IIIA3)
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A4 Macaca mulatta (rhesus monkey)
Formerly named CYP3A64
Analysis of the genomic DNA shows this gene is syntenic with
human CYP3A4 so it has been renamed CYP3A4
NM_001040414
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA
CYP3A4 Macaca mulatta (rhesus monkey)
NP_001035504
UCSC Browser chr3:47026931-47056683 (-) strand
syntenic with CYP3A4 human
CYP3A4 Pongo pygmaeus (orangutan)
EF589794.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a4
93% to 3A4 human
LAMETWILLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNV
FSYRKGFWRFDMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRPF
GPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIARYGDVLVRNLRREAET
GKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSII
VFPFLTPILEILNISVFPREVTSFLRKSVKRMKESRLKDTQKHRVDFLQLMIDSQNSK
ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQRKLQEEIDAVLP
NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPS
YALHHDPKYWTEPGKFLPERFSKKNKDNIEPYVYTPFGTGPRNCIGMRFALMNMKLAV
IRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKVESRDG
CYP3A4 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a4
93% to 3A4 human
CYP3A4-ie1b human
GenEMBL NT_007933.10|Hs7_8090
alt exon 1 (partial)
24614522 LIPNLAVETWLLL 24614484
CYP3A4-ie1b Macaca mulatta (rhesus monkey)
UCSC browser chr3: 47055991-47055947 (-) strand
Ortholog of human CYP3A4-ie1b internal duplicate exon 1
47055991 MDLIPNLAMET*LLL 47055947
CYP3A4v1 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
CYP3A4v2 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
1 aa diff to 3A4v1, 4 nuc. diffs
CYP3A5_v1 human
PIR A60558 (29 amino acids)
Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
Identification of a polymorphically expressed member of the
human cytochrome P-450III family.
Mol. Pharmacol. 36, 97-105 (1989)
CYP3A5_v1 human
GenEMBL S74699 (1526bp) S74700 (1667bp)
Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
Sequence of the 5'-flanking region of CYP3A5: comparative analysis
with CYP3A4 and CYP3A7.
Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)
CYP3A5_v1 human
GenEMBL AC005020 genomic sequence 13 exons
Same intron exon structure as CYP3A43 from human
CYP3A5-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7
alt exon 1 and 2 upstream of 3A5
239409 MDLIPNLAVETWLLLAVSLVLLYL
243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697
CYP3A5-de13c human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 detritus exon 13 upstream of 3A5
old name = 3A51P
254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
CYP3A5_v2 human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
formerly CYP3A5P1, new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5-de1b2b3b14n4b15n Macaca mulatta (rhesus monkey)
between CYP3A7 and CYP3A5 there is a pseudogene
containing 6 exons, including the cryptic exons 14n and 15n
found in the human alt. splice form CYP3A5_v2
This pseudogene is syntenic with human CYP3A5_v2
But in humans the cryptic exons exist inside the 3A5 gene
not outside it. This suggests a deletion event happened in humans.
Loss of the first 4 exons in the ancestral 3A5 gene would make
The current human gene possible.
82% to CYP3A5_v2 alt splice from the CYP3A5 gene
MDLIPNLAVETWLLLAVSLVLLYL (2) exon 1
YGAHSHGLFKKLGIPGPTPLPFLGTTLSYRQ (0) exon 2
GLWKFDTECYKKYGKMWR (2) exon 3
SSLFGPHYPSSYEDLNDSYVRLLLCVTP**TRT*DCYALHNWG () cryptic exon 14n
YKGQQPVLAITDPNMTKTVLVKEYYSVFTNQR (0) exon 4
ICATTSMIKMQTHSITMWLPPAILQSQ cryptic exon 15n
CYP3A5_v3 human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
formerly CYP3A5P2, new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P1X human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P2X human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology formerly CYP3A66
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A5_2-F5
3 aa diffs to 3A5 Macaca mulatta
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
91% to 3A5 human, 84% to 3A4, 80% to 3A7, 75% to 3A43
100% identical to Unos seq.
CYP3A5 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5b
89% to 3A5 human, probable ortholog of CYP3A5
note: there is a second gene CYP3A90 that is 95% identical to this
it is a paralog of the CYP3A5 gene
CYP3A5 Pongo pygmaeus (orangutan)
EF589795.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a5
98% to 3A5 human
WLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQ
GLWKFDTECYKKYGKMWGTYDGQLPVLAITDPDMIKTVLVKECYSVFTNRRSLGPVGF
MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFSFLDPLFLSIILFPFL
TPVFEALNVSLFPKDTINFLNKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH
KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP
TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGAMVVIPTYALHH
DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN
FSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGE
CYP3A6 rabbit
GenEMBL J05034, M19139
CYP3A7 human
NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
CYP3A7-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 alt exon 1 and 2 upstream of 3A7
186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2
CYP3A7 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
89% to human CYP3A7, 89% to human CYP3A4
82% to human 3A5 and 73% to 3A43
note: this seq is equally similar to 3A7 and 3A4
but there is another seq with a better match to
3A4 in African green monkey, so this must be
the 3A7 ortholog
CYP3A7 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a7
96% to 3A7 human
CYP3A7 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a7-like
92% to 3A7 human
CYP3A7 Macaca mulatta (rhesus monkey)
AANU01101873.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a7-like
UCSC browser chr3:46903541-46929928 (-) syntenic with CYP3A7
91% to CYP3A7 human, 88% to CYP3A4, 82% to CYP3A5
24981 MDLIPDLAVETWLPLAVSLILLYL
YGTHSHGLFKKLGIPGPTPLPFFGNVLSFRK 29288
34310 GFWTFDMECYKKYRKVWG 34363
35908 FYDCRQPVLAITDPNMIKTVLVKECYSVFTNRR 36006
38516 PLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKE 38629
38894 MVPIIAQYGDVLVRNLRREAETGKPVTLKD 38983
40270 VFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDPFFLSIK 40416
41507 IFPFLTPIFEALNITVFPRKVTRFLRKSVKRMKEGRLKETQK 41632
42652 RRVDFLQLMIDSQNSKDTESHK 42717
45311 VLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDTVLPNK 45472
46900 APPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGVVVMIP
47094
47095 SYVLHHDPKYWTEPEKFLPER
48220 RFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 48384
51270 IPLKLSFGGLLKTEKPIVLTAESRDGTVSGA* 51371
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A9 rat
GenEMBL U46118(2101bp)
Wang,H., Kawashima,H. and Strobel,H.W.
cDNA cloning of a novel CYP3A from rat brain
Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)
CYP3A9 rat
GenEMBL U60085(1882bp)
Nef,P.
Hepatic expression and inducibilty of CYP3A9 and other members of
the rat CYP3A subfamily.
unpublished (1996)
CYP3A9 rat
UCSC Browser chromosome 12
some frameshifts in genome seq of exon 8
17153442 MDLIPNFSMETWLLLVISLVLLYL 17153513
17155488 YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK 17155580
17156990 GFWEFDKYCHKKYGKLWG 17157043
17159222 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17159320
17163193 NFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKE 17163306
17163523 MFPIINQYTDMLVRNMRQGSEEGKPTSMKD 17163606
17165013 IFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSV 17165159
17168128 TLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKE 17168226 NRMKEKEK
17170690 QRMDFLQLMINSQNSKVKDSHK 17170755
17177660 ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK 17177821
17179040 AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
VVMIPTFALHKDPHYWPEPEEFRPE 17179264
17191573 RFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKET 17191734
17192800 QIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA 17192895
CYP3A9-se1[4]X rat
UCSC Browser chromosome 12
Note: the revised genome probably has this as part of Cyp3a62
Discontinued name
17387311 LYEGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17387213 exon 4
CYP3A9-se1[1:2:4] rat
193 kb downstream of Cyp3a9 on opposite strand
100% match to Cyp3a9
MDLIPNFSMETWLLLVISLVLLYL
YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK
LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR
CYP3A10 hamster
GenEMBL M73992 (2015bp)
Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequence of a new rat CYP3A form
unpublished (1993)
Cyp3a11 mouse
PIR A60564 (24 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
Cyp3a11 mouse
GenEMBL X60452, AC111090.20 genomic clone (seq shown)
104114 MDLVSALSLETWVLLAISLVLLYR 104185
106160 YGTRKHELFKKQGIPGPKPLPFLGTVLNYYK 106252
108416 GLWKFDMECYKKYGKTWG 108469
110360 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR 110458
114653 DFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKE 114766
114846 MFPVIEQYGDILVKYLRQKAKKGKPVTMKD 114935
115207 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSV 115353
117878 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQK 118006
118896 HRVDFLQLMMNSHNNSKDKVSHK 118964
121382 ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK 121543
123352 APPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALH
HDPQHWSEPEEFQPER 123579
125008 FSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 125169
128728 IPLKLSRQGLLQPEKPIVLKVVPRDAVITGA 128820
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a11-de12bX mouse
old name Cyp3a-se11[12] also = Cyp3a-se6[12]
this fragment has joined with Cyp3a44-de9b10b11b
to make Cyp3a44-de9b10b11b12b (see below)
137165 RFSMENKGSIDPY 137127
137122 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 136997
CYP3A12 dog
PIR S04341 (28 amino acids)
Ciaccio, P.J. and Halpert, J.R.
Characterization of a phenobarbital-inducible dog liver
cytochrome P450 structurally related to rat and human
enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Arch. Biochem. Biophys. 271, 284-299 (1989)
Cyp3a13 mouse
GenEMBL X63023(1881bp) also NT_039315.1
Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
Molecular cloning and functional expression of a mouse cytochrome
P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
aflatoxin B1 (AFB1).
Biochim. Biophys. Acta 1201 (3), 405-410 (1994)
CYP3A14 Cavia cobaya (guinea pig)
GenEMBL D16363 (1827bp)
Mori,T., Itoh,S. and Kamataki,T.
cDNA and deduced amino acid sequence of a novel cytochrome
P450 from male guinea pig liver mRNA with high homology to
CYP3a family
unpublished (1993)
CYP3A14 Cavia porcellus (guinea pig)
GenEMBL D49731 (2321bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
CYP3A15 Cavia cobaya (guinea pig)
GenEMBL D26487 (2163bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
Cyp3a16 mouse
GenEMBL D26137 (1701bp) also NT_039318
Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning
and expression in fetal liver.
Eur. J. Biochem. 226, 877-882 (1994)
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a16-de12b mouse
GenEMBL NT_039318 - strand
detritus exon 12
z in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1616751 GPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1616647
CYP3A17 guinea pig
GenEMBL D28515
Mori,T.
submitted to Nomenclature Committee
Not in Genbank as of 6/26/95
CYP3A18 rat
no accession number
Kiyoshi Nagata
6-beta-C
submitted to Nomenclature Committee
CYP3A18 rat
GenEMBL X79991 (2005bp)
Strotkamp,D., Roos,P.H. and Hanstein,W.G.
A novel CYP3 from female rats.
Biochim. Biophys. Acta 1260, 341-344 (1994)
CYP3A18 rat
GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
Yamazoe,Y. et al.
Isolation and characterization of of a new rat P450 (CYP3A18) cDNA
encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
Pharmacogenetics in press (1995)
CYP3A18 rat
UCSC Browser chromosome 12
9166475 MEIIPNLSIETWVLLATSLMLFYI 9166404
9156355 YGTYSHGLFKKLGIPGPKPVPLFGTIFNYGD 9156263
9143764 GMWKFDDDCYKKYGKIWG 9143711
9141173 FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR 9141075
9137566 CFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKE 9137453
9136038 MFPLMRQYGDTLLKNLRREEAKGEPINMKD 9135949
9135719 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSV 9135573
9133657 VLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQK 9133529
9132027 NRVDFLQLMMNTQNSKGQESQK 9131965
9129047 ALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK 9128886
9126077 APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
VVTIPIYPLHRNPEYWLEPEEFNPE 9125853
9120566 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 9120405
9117192 QIPLKISRQPIFQPEGPIILKLVSRD 9117115
CYP3A18-se1[5:6:7:8] rat
UCSC Browser chromosome 12
64% to 3A18
9216052 FGPVGFMKKAVTISEDDEGKRLRPLLSPVFTSGK 9216153
9216386 LWLLHFGLMCSPSSGSVMSVKHLRQEEKGEPIHMKE 9216493
9216722 FSGAYSMNGIAGASFGVNVDSLNN 9216781
XXXXXXXXXXXXXXXXXXXXXXXX
VVLFPFLTQI
CYP3A19 Capra hircus (goat)
GenEMBL X76503 (1084bp)
Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
cDNA and deduced amino acid sequence of a dwarf goat liver
cytochrome P450-fragment belonging to the CYP2C gene subfamily
Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
C-terminal fragment from I-helix to end
CYP3A20 Guinea pig
GenEMBL
T. Mori
unpublished
CYP3A21 Marmoset
GenEMBL
Igarishi, T.
unpublished
CYP3A22v1 Miniature pig
GenEMBL AB006010
Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
Drug Metab. Disp. 32, 376-378 (2004)
CYP3A22v2 Sus scrofa (pig)
AK233355
Uenishi,H., Eguchi,T., Suzuki,K., Sawazaki,T., Toki,D., Shinkai,H.,
Okumura,N., Hamasima,N. and Awata,T.
PEDE (Pig EST Data Explorer): construction of a database for ESTs
derived from porcine full-length cDNA libraries
Nucleic Acids Res. 32 (DATABASE ISSUE), D484-D488 (2004)
This seq has 8 aa diffs to CYP3A22 and is an exact match to the
hybrid seq CYP3A46v2 last 61 aa
MDLIPSFSVETWL
LLATSLVLLYLYGTYSHGLFKKLGIPGPKPLPYFGSVLEYRKGMWHFDNKCFKKYGKMWG
FYDGRQPVLAMRDPEMIKAVLVKECYSAFTNRRNFGPAGVMKNAISVAKDEQWKRVRTLL
SPTFTSGKLKEMFPIIAQYGDMLVRNLRKEAEKGNSINTKEIFGAYSMDVITSTAFGVNV
DSLNNPRGPFVQYARKLLRFDFLDPFILSIILFPFLSPFFEVLDITLFPRSSAKFFTQSV
KRMKESRLKDQQMRRVDLLQLMINSQNSKETDAHKALSDQELVAQSIIFIFAGYETTSSS
LSFLAYILATHPDVQQKLQEEIDATFPSKALPSYDSLAQMEYLDMVVNEILRLYPIAARL
ERVCKKDVEIHGVSVPKGTVMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDTINPYTYL
PFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKV
VPRDGTVSGA
CYP3A23 rat
GenEMBL D13912
Kirita,S. and Matsubara,T.
Cloning and characterization of a novel member of steroid induced
cytochrome P450 3A in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
GenEMBL D29967
Komori,M. and Oda,Y.
A major glucocorticoid inducible P450 in rat liver is not P4503A1
J. Biochem. 116, 114-120 (1994)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
UCSC Browser chromosome 12
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
9625823 MDLLSALTLETWVLLAVVLVLLY 9625755
9623782 GFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM 9623687
9621110 GLWKFDVECHKKYGKIWG 9621057
9617991 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR 9617893
9616272 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKE 9616159
9616079 MFPVIEQYGDILVKYLRQEKGKPVPVKE 9615996
9615715 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV 9615569
9614012 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDS 9613893
9613004 VQKHRVDFLQLMMNAHNDSKDKESHT 9612936
9607896 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNK 9607735
9605981 APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKG
SVVMIPSYALHRDPQHWPEPEEFRPE 9605757
9604349 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 9604188
9597247 QIPLKLSRQGLLQPTKPIILKVVPRDEIITGS 9597152
CYP3A24 sheep
GenEMBL U59378(1653bp)
Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
and Morgan,D.J.
Ovine foetal liver CYP3A24
unpublished (1996)
Cyp3a25 mouse
GenEMBL AF204959
Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
submitted to Nomenclature Committee 10/18/96
Cloning, sequencing, heterologous expression and characterization
of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
Unpublished
MELIPNLSIETWVLLVTSLVLFYI
YGTYSHGLFKKLGIPGPKPLPLLGTIFNYYD
GMWKFDEDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
FFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPISMKD
IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKVFDPFLLS
IILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ
IPLKISREPIFQPEKPIILKVVSRDKPRTGS
Cyp3a25 mouse
GenEMBL Y11995
Mahnke,A., Roos,P. and Hanstein,W.G.
one amino acid difference with Roses sequence at amino acid 215
unpublished
Cyp3a25 mouse
GenEMBL AC111090.20 genomic clone
Last two exons. This clone also contains CYP3a11, Cyp3a44 and the
region between them. This helps to close the gap in the 3a cluster
shown in Fig 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
2345 FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 2506
6188 IPLKISREPIFQPEKPIILKVVSRDKPRTGS 6280
Cyp3a25-de8b9b12b mouse
GenEMBL AC111090.20 genomic clone
r in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
27841 PVFFSFLIPI*EMLNISVFQKGSIAFFKKFVDRMNESRPDSKQK 27710
18903 DLVGFLQPMINAHNNPKDKESHNG 18832
15460 XXXXXXGSID-YVYLSFGNGPRIYIGVRFTLMNMKVLTLTKVLHNFSFHPCKET* 15317
Cyp3a25-de11c mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
q in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
168333 XPVTLGTLVEIEYPDMVVT*ILILYPIGNRPESVCKEGFEVFIPKGTRVTVPTFALH*DPQYWPELEKXXXXX 168133
CYP3A26 dog
no accession number
David Fraser
submitted to Nomenclature Committee
95.6% identical to 3A12 from dog
CYP3A27 Oncorhynchus mykiss (rainbow trout)
GenEMBL U96077
Don R. Buhler
Arch. Biochem. Biophys. 360, 000-000 (1998) in press
56% identical to 3A12
CYP3A28 Bos taurus (cow)
GenEMBL Y10214(1870bp)
Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
Witkamp,R.F. and Horbach,G.J.
Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
and its functional expression in V79 cells.
unpublished (1997)
CYP3A28 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLATSLVLLYI (2)
YGTYSYGLFKKLGIPGPRPVPYFGSTMAYHK (0)
GIPEFDNQCFKKYGKMWG (2)
FYEGRQPMLAITDPDIIKTVLVKECYSVFTNRR (0)
IFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKE (0)
MFPIIGQYGDMLVRNLRKEAEKGNPVNMKD (2)
MFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSI (1)
ILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQM (0)
NRVDLLQLMINSQNSKEIDNHK (1)
ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNK (0)
APPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPER (2)
FSKNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQ (0)
IPLKLYTQGLTQPEQPVILKVVPRGLGPQVEPDFL*
CYP3A29v1 pig
GenEMBL Z93099 (2015bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA
CYP3A29v2 Sus scrofa (pig)
GenEMBL AB052260
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
2 amino acid diffs with 3A29v1
clone name 3Ac9
CYP3A29v3 Sus scrofa (pig)
GenEMBL AB052261
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1
clone name 3Ac16
CYP3A29v4 Sus scrofa (pig)
GenEMBL AB052262
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
clone name 3Ac25
CYP3A29v5 Sus scrofa (mini pig)
GenEMBL AF424780
Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
cDNA of minipig cytochrome P450 3A
Unpublished
75% to 3A4 human 98% to 3A29v1 8 diffs.
3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
4 diffs with 329v2 (Partial seq from 99-328)
CYP3A30 Fundulus heteroclitus
Genbank AF105068
Malin Celander and John J. Stegeman
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the
marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A
genes.
Biochem. Biophys. Res. Commun. 236, 306-312 (1997)
CYP3A31 Syrian hamster
GenEMBL D86951
Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
Nagata,K. and Yamazoe,Y.
cDNA cloning and expression of a novel CYP3A from the Syrian
hamster, CYP3A31
Biochim. Biophys. Acta 1397, 9-13 (1998)
clone name P450SH3A-1
CYP3A32 Balaenoptera acutorostrata (Minke whale)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A33 Phocoenoides dalli (Dall's porpoise)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A34 Eumetopias jubatus (Steller sea lion)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A35 Phoca largha (Spotted seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A36 Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A37 Gallus gallus (chicken)
no accession number
Manuel Baader and Urs Meyer
submitted to nomencalture committee
60% identical to mammalian CYP3A sequences
CYP3A37 Gallus gallus (chicken)
GenEMBL NM_001001751.1
Note: chicken has two CYP3As about 25kb apart on chr 14
See CYP3A80
MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI
QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI
ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ
QKVVNEIDTILPNKAPLTYEAIMQLEYLDMAVNETLRLYPLGGRLERTCKRDVEINGV
TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG
MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPRTNTAKA
CYP3A37 Meleagris gallopavo (turkey)
No accession number
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F4
92% to chicken 3A37 probable ortholog
CYP3A37 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_1137:6582-24650,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca4.
69% to CYP3A37 chick (ortholog), 64% to CYP3A113,
63% to CYP3A98 dog, 63% to 3A80 chicken
MELLPSFSIETWSFLVVLLGLLLLYGIWPFGVFGKLGIPGPRPWPFLGTLLQYRKGFVKFDSWCFQKYGRIWGIYDGRQPVM
AILDPAIIKTVLVKECYTTFTNRRNFGATGVLKSAISLAEDEHWKRVRTVLSPTFTSGKLKEMFPIIKHYGEALMRNVQKKV
DMDEPLVVKDVFGAYAMDVVTSTSFGVNIDSMNNPKDPFVKEIQKLTKFRSFDPRIILLFTFPILRTVFEALNIQIFSAEAV
DFFTRSFAKMKAGRAGETKEGRVDFLQLMIDSQTSNGHHQSNGIDHTYKGLTDDEILAQAFIFVFAGYEPTSNSLGYMAYML
ATHPDVQQKLQDEIDSVLPNKAPLTYDAIMQLEYLDMVLNETQRLYPLGGRIERVCKKDVEINGVTIPKGVVVMIPPYNLHR
DQEYWPEPEEFRPERFSKENKESVDPYTYLPFGAGPRNCIGMRFALVTMKVAITILLQHFSFRVCKETPIPLELSSQAFLVP
EKPIVLKLVRRNNLQ
CYP3A38 Medaka (fish)
no accession number
Seth Kullman
submitted to nomenclature committee 11/6/98
72% identical to CYP3A27 trout
CYP3A39v1 Sus scrofa (pig)
GenEMBL AF109068, NM_214422
Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
Porcine Cytochrome-P450 with high protein homology to human CYP3A4
(Nifedipine oxidase J04449)
Unpublished
88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA
CYP3A39v2 Sus scrofa (pig)
GenEMBL AB052263
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
clone name 3Ac13
CYP3A39v2 Sus scrofa (pig)
Be aware that there is a sequence in Genbank called CYP3A39v2
With accession number EF625354
This sequence is really CYP3A46v3
with one amino acid difference to CYP3A46
CYP3A39v3 Sus scrofa (pig)
GenEMBL AB052264
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
clone name 3Ac19
CYP3A39v4 Sus scrofa (pig)
GenEMBL AB052265
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
clone name 3Ac32
CYP3A39v5 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence with frameshifts before I-helix
95% to CYP39A1v1 NM_214422
only 2 aa diffs in first 193 aa
CYP3A40 medaka
no accession number
Seth Kullman
submitted to nomenclature committee 1/12/99
90% identical to CYP3A38 trout
Cyp3a41 mouse
GenEMBL NM_017396 AB033414
Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene
subfamily in the mouse liver
Arch. Biochem. Biophys. 377 (1), 153-162 (2000)
91% identical to 3a11 87% identical to 3a16 69% to 3a25 and
68% to 3a13 90% to 3a44
submitted to nomenclature committee 6/1/99
MNLFSALSLDTWVLLAIILVLLYR
YGTRTHGLFKKQGIPGPTPLPFLGTVLNYYK
GLWKFDMECYEKYGKTWG
LFDGQMPLFVITDPEMIKNVLVKECFSVFTNRR
EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKE
MFPVIEQYGDILVKYLMQEAEKGKPVTMKD
VLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFS
VVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQK
HRVDFLQLMMNAHNNSKDKDSHK
ALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK
APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPER
FSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ
IPLKLSRQGLLQPEKPIVLKVVPRDVVITGA
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a41-de1b2b mouse
GenEMBL NT_039318
exon 1,2 - strand
y in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
possible alternative exons for 3a41
1729618 MNLFSALSLDTLVLLAIILVLLYR 1729547
1727537 YGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK 1727445
Note: These two exons are identical to 3A16 exons 1 and 2
This sequence is at the edge of the genome sequence gap between 3a41 and 3a44
The NT_039318 sequence has been removed in the new mouse genome assembly,
So these sequences could be due to errors in assembly.
Cyp3a41-de12c mouse
GenEMBL NT_039318 - strand
detritus exon 12
x in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1739825 SNGPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1739715
note this seq is nearly identical to Cyp3a16-de12b
it is in a region of some uncertainty, and may be due to errors in assembly.
CYP3A42 Python regius (ball python or royal python, African snake)
GenEMBL AF319041
Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
Submitted to nomenclature committee Oct 22, 1999
59% to mouse 3a
CYP3A43 human
GenEMBL AC011904 8902-46787 13 exons
Gene assembled from genomic sequence by Henry Strobel
and David Nelson on Dec 11, 1999
intron exon boundaries defined by comparison to rat 3A9
and human 3A sequences. GT AG pairs found for all introns
ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
Opposite ends of same clone
67% identical to rat 3A9
Assembled gene * = intron exon boundary ** = EST support for this boundary
MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI*
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*
coding region 504 amino acids
exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787
CYP3A43-de1b human
GenEMBL NT_007933.10|Hs7_8090 + strand alternate exon 1
24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214
CYP3A43-de4c6c
GenEMBL NT_007933.12|Hs7_8090
chromosome 7 genomic contig
Length = 64383103
Last exon of 3A43 in build 33 of human genome
24697113 IPLKLDNLPILQPEKPIVLKVHLRDGITSGP* 24697208
CYP3A43-de4c6c = s in Fig. 3A,
old names = 3A52P, 3A53P
Exon 4 pseudogene fragment
24701048 MIKTVLVKECYSVFPNWR 24701101
exon 6 pseudogene fragment
24703375 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 24703464
CYP3A43 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A43
96% to human CYP3A43 only 75% to 3A4, 3A5
CYP3A43 Macaca mulatta (rhesus monkey)
XM_001098213.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a43
96% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETSLHHSLSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQLPLKLNNLPILQPENPIVLKVHLRDGITSGP
CYP3A43 Macaca mulatta (rhesus monkey)
NP_001121102
UCSC Browser chr3:47099079-47140713 (+) strand
CYP3A43-de1b Macaca mulatta (rhesus monkey)
UCSC Browser chr3: 47090970-47091041 (+) strand
Ortholog to human CYP3A43-de1b, 4 aa diffs
pseudogene exon 1 between 3A4 and 3A43 (+)
8 kb upstream of CYP3A43
47090970 MDLIPNFAMDMWVLPATRLVLLYL (2) 47091041
CYP3A43-de4c6c Macaca mulatta (rhesus monkey)
UCSC Browser chr3: 47144523-47146892 (+) strand
ortholog to the human pseuddogene, 1 amino acid difference
47144523 MIKTVLVKECFSVFPNWR 47144576
47146803 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 47146892
CYP3A43 Pongo pygmaeus (orangutan)
EF589793.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a43
98% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RQEAENSKSINLKDFFGAYAMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLLISLFPFLTPVFEALNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVLIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
Cyp3a44 mouse
GenEMBL AB039380
Tsutomu Sakuma
Submitted to nomenclature committee 2/29/2000
This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)
Cyp3a44 mouse
GenEMBL AC111090.20 genomic clone
This clone contains part of 3a25, Cyp3a25-de8b9b12b, 3a11,
A pseudogene between 3a11 and 3a44, and most of 3a44
178101 MNLFSALSLDTLVLLAIILVLLYR 178172
180134 YGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT 180226
182562 GIWKFDMECYEKYGKTWG 182615
184471 LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRR 184569
188874 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 188987
189067 MFPVIEQYGDILVKYLRQEAEKGMPVAMKD 189156
189424 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSV 189570
192147 VLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQK 192275
193171 HRVDFLQLMMNSHNNSKDKDSHK 193239
195368 AFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNK 195529
204141 ATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPS 204308
204309 YALHHDPQHWPDPEEF 204356 (runs off end, last section from AB039380)
QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLA
VTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA
Cyp3a44-de9b10b11b12b mouse
GenEMBL AC111090.20 genomic clone
This seq is between 3a11 and 3a44. It is 13kb from 3a44, 20kb from 3a11
The exon 12 part used to be called Cyp3a11-de12b
The exon 9 part is identical to w in Figure 3B Nelson et al.
Pharmacogenetics 14, 1-18 2004.
165130 HQVDFLHLMINAHDKTKDKETHK 165062
160280 ALSNMEITTQSIMFIFASYKPTSSTLSFALCSLVTHHAS*KKLQENDKTLTNK 160122
156349 VELESLDMVLNETLRLYPTADRLVKVYKKDVELNDAFILKWSLEIVSCYSLCHDPQNWPEHKEFCPE 156149
148858 RFSMENKGSIDPYG 148817
148815 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 148690
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Note: the following sequences (4 exons) lie between 3a41b and 3a44
Cyp3a41b-de12b
(-)15459 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQ 15298
3 aa diffs to Cyp3a-se5[12]
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A45 Oncorhynchus mykiss (rainbow trout)
No accession number
Su-Jun Lee, Don R. Buhler
96% to 3A27 but different 3 prime and 5 prime ends
CYP3A46 Sus scrofa (miniature pig)
EF625347
Haitao Shang
Submitted to nomenclature committee May 23, 2007 (partial)
Complete sequence in Genbank 03-SEP-2008
92% to 3A39v1, 76% to human 3A4 and 3A5
formerly CYP3A88. Name changed to CYP3A46 after whole sequence known
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRSAVSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNVDSLNNPQDPFVENSRKLLKFSFFSP
FFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSIKRMKESRLKDTQKHRVDLLQLMI
NSQNSKEMDAHKGLSNEELVAQGVIFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPNKAPPTYDGLAQMEYLDMVVNESLRIFPVTPRLERSCKKDVEIHGVFVPKGT
VMMVPIFALHRAPELWPEPEEFRPERFSKKNKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCRETQIPLKISSQGLIQPEKPIVLMVVPRDGTTSGA
CYP3A46 Sus scrofa (miniature pig)
3 aa diffs to CB479861.1 EST, probably the same seq.
F22946.1 extends seq toward N-term.
AJ959509.1 overlaps F22946 with 1 aa diff in 42
Be aware this may be a hybrid of two or more gene sequences.
BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
DB799225.1
92% to 3A39v1
Formerly CYP3A88. Name changed to CYP3A46
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*
CYP3A46v1 Sus scrofa (pig)
GenEMBL AB052266
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
clone name 3Ac4
two amino acid differences with full length CYP3A46
CYP3A46v2x Sus scrofa (pig)
GenEMBL AB052267
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
clone name 3Ac28
the last 61 amino acids are identical to CYP3A22v2
this sequence appears to be a hybrid of CYP3A46 and CYP3A22v2
CYP3A46v3 Sus scrofa (pig)
EF625354
Partial sequence with 1 amino acid diff to CYP3A46
CYP3A47X Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Renamed CYP3D1
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPPLHDPSTSP (1)
Cannot identify exon 8 in this region
(0) EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3A48 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803
CYP3A48 Tetraodon nigroviridis (freshwater puffer)
CAF91666 GenPept
85% to 3A48 full (probable ortholog), 87% to 3A49 C-term fragment,
MDLLPDFSIETWTLIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGVHHFDQECYKKYGKVWSLFDGRQPLM
CIMDTLMIKTILIKECYSNFTNRRDLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKV
KADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILVVLFPFTQTIFDKMDVSLFPGHVL
DFFYNFLRQIKSDRSKEKKKSRVDFMQLMVNAHMTEDNEKDSSLKGLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNP
DIQKKLQEEIDKTFPGKVRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPAL
WPEPEAFKPERFSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPI
KLKLKPRTSS
CYP3A48 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrXII:12771920-12775348, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
gac2628
70% to 3A48 Fugu, 72% to tetraodon 3A48,
MGFLPELSIQTWTLIVFLVTLITVYGYAPYGFFKKLGIPGPRPLPFIGTFLEYRKGIHNFDTECYEKYGKVWGIYDGRVPIL
VTMDTAMIKSILVKECYSNFTNRRDFGLNGALRDAITVVEDEEWKRIRSILSPSFTSGRLKEMYSIMLQHSGNLIKSLHKKA
EAGEVVDVKDIFGPYSMDVVASTAFSVDIDSINNPSDPFVANIRKLVKFTFLTPLFLLLVLFPFLEPMLDKMNVTLFPAELL
DFFYSFLKTIKSDRSKNEHKNRVDIMQLMVDSQMSETTKEDPSAHKGLSDSEILSQAMIFIFAGYETSSGTLGFLAYNLATN
PDIQKTLQEEIDETFPNKARPTYDALMQMEYLDMVLNESMRLYPSGNRLDRVSKSSVEIEGVTIPKGTVVMIPVYTLHREPT
LWPEPDDFKPERFSKENKDSIDPYSYLPFGAGPRNCIGMRFALLMMKLSVVEILQNFSFVTCKETQIPLELSTDGFTTPKDS
INLKLEPRGAHC
CYP3A49 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124b length 48103 gene runs off end of scaffold
48101 XXXXYEILAQ 48804 frameshift
48084 AIFFIFAGYELPAALLDFANNLATNPKIQKKLQEEIDKTFPGK 47956 (0)
47876 VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQ 47697
47696 RDPVLWPEPEAFKPER 47648 (2)
47492 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCQETD (0) 47331
47246 IPMVLGNEGFVTPKNPIKLKLKLRDVFN* 47160
CYP3A50P Fugu rubripes (pufferfish)
No accession number
Scaffold 10760 probable pseudogene
1847 MNFLPDFFLNTWTFLILVIVLSTT 1918 (2) exon 1
2258 bad boundary MDVLHMSSIKRVGIRRPKTWPIIGTYNRTDG 2350 bad boundary exon 2
cannot identify exons 3-6
3091 XXXXXXXXXXXXXXFSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG 3195 (1) part of exon 7
3268 AIFPFLTPLMD 3300 start of exon 8
Seq gap in scaffold
3919 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNLAVHPQTQTRLQAEIDRTFPGK 3990 exon 10
4078 CLITYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSGVIIPEGVAVAVPIYTLH 4257
4258 RDPTVWPDPDSFKPERFSKDNRDNIDPYGLLTR 4424 frameshift and 7 nuc. deletion
4423 GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM 4527
IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN* 4787
CYP3A51PX human
NT_033964.1|Hs7_34119 chromosome 7
detritus exon 13 upstream of 3A5
new name = CYP3A5-de13b
254205 QIPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
CYP3A52PX human
AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4
New name = CYP3A43-de4c6c
MIKTVLVKECYSVFPNWR
CYP3A53PX human
NT_033964.1|Hs7_34119 Homo sapiens chromosome 7
detritus exon 6 downstream of 3A43
new name = CYP3A43-de4c6c
67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6
CYP3A54PX human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
new name = 3A-se1[2]
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A55PX human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
new name = 3A-se2[5]
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
CYP3A56 Fundulus heteroclitus (killifish)
No accession number
Tove Hegelund and Malin Celander
64% to 3A48 Fugu 99% to 3A30
submitted to nomenclature committee 6/20/02
Cyp3a57 mouse
GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
AC115895.4 13 exons, exon 9 is backwards
NT_039318
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP
Cyp3a58-ps mouse
GenEMBL NT_039318 + strand
Between 3a16 and 3a41
Note this seq is 86% identical to Cyp3a44-de9b10b11b12b
[3a16, 3a58-ps, 3a41] is probably a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11]
exon 8
1629527 PVFFSFLNPI*EMLKISVFPKDSIAFFKKKLWTEQRKTSWILSKR 1629661
exon 9 new fron UCSC Browser
26701 HQVDFLHLMINAHDNTKDNESHK 26769
exon 10
1651425 ALSNIEITTQSIMFIFASYEPTSSTLSFVLYLLVTHHDIWKKLQENDRALPNK 1651583
exon 11
1660734 VEMEYLDMVLNETLRLYPTADRFVKVYKKDVELNDAFILKWS 1660859
exon 12
1669382 FSMENKGSIDPYX 1669417
1669422 YMPFGNGPRNCISMRFAVMSMKFALTKVLQNCYLHPCKETQ 1669544
Cyp3a59 mouse
GenEMBL NW_000248.1|Mm5_WIFeb01_96 gene interrupted by gaps
AC113316.2
old temp name = cyp3agg
93% to Cyp3a25
LLLYRYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFD
GMWKFDEDCYKKYGKIWG
FYVGPKPILAIMDPEIIKIVLVKECYSVFTNR
RLLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPINMKE
IFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLS
VVLFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLH
RNPEYWPEPQEFCPG
RFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQ
IPLKISREPVFQPEKPIILKVVSRDKPRT
Cyp3a59-de11b mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
p in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
191646 VSFLLVTLVEIEYLDILVT*ILRLNPIGNRLESVSKK 191536
191539 EMFEVFIPKGTRVTVLTFALH*DEQYWPEXXXXXXXX 191453
Cyp3a60-ps mouse
GenEMBL NT_039324.1 + strand
Cyp3a ps about 60% to 3A25
exon 2
331420 PVRLPVIGLLLSLYN 331464
exon 5
338061 KKVITISEEDERKRL*TLLSPTFIS 338135
exon 6
338410 MFPIIGQYGETLVK 338451
338451 KKRKGEPINMKE 338486
exon 7
338734 SMDVVTGTLFGVNVDSLTNSSDPCAESQGDLNKFEFS*PTSLG 338862
exon 8
341951 VAMLPFLTTIYKILSISIFP 342010
342409 KYMKQSRLDTNQK 342447
Cyp3a61-ps mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3ayyp
Exons 10,11,12,13
1115767 ALSDLEIVAQSISFIFAGYETTSNTLSYIMYTLATHPDVQKKLQQEIDAILPNK 1115606
1113252 APATYNDLEKIEYLDMVINETLRLYPIGARISRLSKKDAEINGVFIPQNTEVAVPVF 1113082
1109396 FSQENKDRINPYVYMPFGNGPRNCLGMRFALINMKLAVVKILQNFSVQPCEDTE (0) 1109235
1108058 IPLKLSKKLILSPEKPIVLKVTARDGAINEG* 7963
Cyp3a61-de11b mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3azzp
detritus exon 11 next to Cyp3a61-ps
n in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1136553 APATYNGLVKIRYLDMVINETLRLYPVGVRISRLSKKDAEINGVLTPQNTK
VDVALFVLH*DPEYWPXXXXXXXXX 1136353
CYP3A62 rat
GenEMBL AB084894
Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
Isolation and characterization of a novel rat CYP3A, CYP3AL1,
predominantly expressed in intestinal tract Unpublished 2003
80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD
Cyp3a62-de11b rat
GenEMBL NW_001084671.1 11932479-11932637
11932637 KKNQDSISPYVYLPFGFRPRNCIGMRFALMNMKVALVRVLQNFSFQPCKEIQL 11932479
Cyp3a63-ps mouse
The following seqs are part of one pseudogene 3a63-ps
GenEMBL NT_045749.1|MmUn_45789_30
3a exon 2 same as 3a63-ps
396 YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK 304
NT_071156.1|MmUn_71196_30
exons 5,6,7 same as 3a63-ps
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
old name = Cyp3a44-se3[10] NW_037585.1|MmUn_WIFeb01_5425
3 diffs to 3a44
same as CYP3A63-ps
649 AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
old temp name = Cyp3attp
80% to 3a11 NW_008810.1|MmUn_WIFeb01_17679
one frameshift and small deletion same as CYP3a63-ps exon 11
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPS
YALHHHWPESEEFQPER
Old name = CYP3A44-se1[12] NW_005077.1|MmUn_WIFeb01_14285
2 diffs with CYP3a44
1231 RFSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ 1067
Cyp3a63-ps AC114427.2
This sequence is between 3a41a and 3a41b
Note: Cyp3a44-de12c has only one aa diff to this seq
63090 MNLFSALSLDTWILLAIILVLLYR 63019 probable beginning of pseudogene
YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK
GFWKFDMECYEKYGKTWG
LFDGQMPLFVITDP*MIKNVLVKECFSVFTNRR
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
HRVDFLQLMMNAHNNSKDKDSHK
AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPSYALHH(fs)HWPESEEFQPER
FSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ
IPLKLSRQGILQPEKPIVLKVVPRDAVITGA
The following sequences are bewtween 3a41a and 3a63-ps
(-)11231 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQV 11067
two sites have exact matches 145849323- 145849487 between 3a41a and 3a63-ps and
146039664- 146039828 between 3a41b and 3a44
3 aa diffs (94%) to Cyp3a-se5[12] probably a poor quality seq match
Cyp3a-se12[8:9:10]
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
IVERTKENCLDSKQK
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31398 SPVQMEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
The following sequences are bewtween 3a63-ps and 3a41b
Cyp3a-se13[9]
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b12b includes old frag w from map
128725 RFSMENKGSIDPY 128763
128769 GPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQV 128876 = Cyp3a-se10[12]
CYP3A64X Macaca mulatta (rhesus monkey)
Analysis of the genomic DNA shows this gene is syntenic with
human CYP3A4 so it has been renamed CYP3A4
No accession number
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
CYP3A65 Danio rerio (zebrafish)
No accession number
Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu,
Jun-Lan Wang-Buhler, and Donald R. Buhler
Submitted to nomenclature committee 10/10/2003
71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias,
69% to 3A30 Fundulus, 69% to 3A56 fundulus,
56% to 3A37 chicken, 58% to 3A48 fugu 59% to 3A49 fugu, 45% to 3B2
CYP3A66X Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology = CYP3A5
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A5_2-F5
3 aa diffs to 3A5 Macaca mulatta
CYP3A67 Pan troglodytes (chimpanzee)
No accession
Eric Williams, Henry Strobel
Recent gene duplication of CYP3A7
CYP3A67 Pongo pygmaeus (orangutan)
EF589796.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a67
96% to 3A67 chimp
MDLIPNLAVETWLLLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFVGNALSFHKGFWTFDMECYKKYRKVWGFYDGLQPVLAITDPDMIKTVLVKECYSVF
TNRRPLGPVGFMKSAISRAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYADVLVRNL
RREAETGKPVTLKDFFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNSLDP
LTLSIKIFPFLIPILEALNVTVFPREVTSFLTKSVKRIKEGRLKETQKHRVDFLQLMI
DSQNLKDTESHKALSDLELVAQSIVFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWIEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKFALVRVLQNFSFKPCKETQIPLKLRFGGLLRTEKPIVLMAESRDETVSGA
CYP3A68 Large mouth bass
DQ786406
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-a
74% to CYP3A27 trout
MGYFFFFSAETWTLLVALITLIFVYVCWPFGTFKKMGVPGPRPI
PFFGTMLAYKKGFMHFDSECFKKYGKTWGIFDGRQPVLCITDPAMIKTVLIKECYSLF
TNRRNFRLNGELYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLISSM
KKTADKDEPLELKEFFGPYGMDVVTSTAFSVDIDSLNNPTDPFVANIKKMLKFDLFNP
IFLFIAFFPFMAPILEKLEFSFFPKSVLDFFYAALKKIKANRETTKLKNRVDFLQLMI
NSQKNNDLSKVENDKGLNDHEILSQAMIFLFAGYETTSSSLTFLAYNLARNPHVMKRL
QEEVDATFPNKAPVEYQALMQMEYLDSVVNESLRLYPIAPRLERVAKATVEINGLVIP
KGMVVMVPTWPLHRDPDLWPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRF
ALVLMKLAVVEILQTYSFSVCKETEIPIELDIQGLISPKRPIKLKLVPRSEPSN
CYP3A69X Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3A70 Macropus giganteus (Eastern grey kangaroo)
No accession number
Ross McKinnon
Submitted to nomenclature committee Oct. 25, 2004
65% to CYP3A4
NOTE: THIS SEQ IS MOST LIKE RAT 3A9 compared to other rat 3As
Therefore the 3A9 seq may be the oldest of the cluster in rats
3A9 is orthologous to 3a13 in mouse. Both sequences are on the
outside edge of the cluster.
CYP3A71P rat
UCSC Browser chromosome 12
pseudogene 78% to 3A2
9497641 LFEWHTPVFAITDREMIKNVLVKECFSVFTNWR 9497543 exon 4
9468424 DLGPMGIMNKSIAF*KDEEWKRYRALLSPMFTSGKLKV 9468311
9468234 MFPIIKLYGDILVKYLRQEAEKGKPVSVKE 9468145
9467886 IFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKFLRLDYFDPLFISV 9467737
9464756 GLFPFLKPIYDMLNISVFPKDSIAFFKNFVYSMKESHLDSKQK 9464631
9453844 YQVDFFQLMMNAHNNSSESHK 9453782
9451670 FPALSDIEIIAQSIIFTFGGYDTTSSTLSFVLYSLATHSDVQKKLQEEIDHALPNK 9451503
9449744 ASPTYDIVMEMEYLDMVFNETLRLYPVTGRLHRMCKKDIELDGVFIPKG
SMVMIPLYPLQHDPQHWPEPEEFRPE 9449520
9447351 RFSKENKCRTGHYVYLPFGNGPRNCLGMRFALMSMKLAVTKVLQNFSFHPCKET 9447190
9444444 QIPLKLSKQVILKPEKPIVLKVVPRDGVING 9444352
CYP3A72 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
83% to CYP3A28 cow, 78% to 3A5 human, 75% to 3A5,
74% to 3A4, 71% to 3A43
CYP3A73 rat
chr12_random_1.5 (from UCSC browser)
80% to 3A44 81% to 3A41 80% to 3A16 83% to 3A11
86% to 3A2 rat
this gene lies between Cyp3a85-ps and Cyp3a18
MDLVSALSLETWLLLAIILVLFYR (2)
FGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR (0)
GLWKFDMECYKKCGKIWG (2)
LFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR (0)
NIGPVGIMSKSISVAKDEEWKRYRAFLSPTFTSGRLKE (0)
MFPIIEHYGDILVKYLKQKVEKGKPLAMKE (2)
VFGAYSMDVITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSV (1)
VLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHK (0)
HRVDFLQLMMNAHNNSKDKVSHK (1)
ALSDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNK (0)
APPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPER (2)
FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ (0)
IPLKLSRQRLFGPEKPIVLKVVPRDAVITGA*
CYP3A74 Bos taurus (cow)
See cattle page for details
MELILSFSTETWVLLATGLVLLYL (2)
YGTYSYGLFKKLGVPGPRPLPYFGNILSYRK (0)
GVCEFNEECFKKYGKIWG (2)
IFEGKQPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDIKD (2)
IFGAYSMDVITSTSFGVNIDSLGNPQDPFVENVKKLLRFSILDPFLLAV(1)
VLFPFLVPILDVLNITIFPKSAVNFFTKSVKRIKESRLKDNQK(0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPEPEEFRPER (2)
FSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0)
IPLKISSQGVLRPEKPVVLKVVLRDGTISGA*
CYP3A75 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLSISLVLLYL
YGTYSHGLFKKLGVPGPRPLPYFGNVLSYRK
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSV
VLFPFLVPIFEVLNITMFPKSAVNFLAKSVKRIKESRLKDNQK
PRVDFLQLMINSQNSKETDNHK
ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDVTFPNK
APPTYDVLAQMEYLDMVVNETLRMFPITVRLDRLCKKDVKIHGVSIPKGTTVTVPISVLHRDPQLWPEPEEFRPER
FSKKNKDTISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKSCKETQ
IPLKINSQGLIRPEKPIFLKVVLRDETISGA*
CYP3A76 Bos taurus (cow)
See cattle page for details
MELIPNFSVETWVLLAISLVLLYL(2)
YGTYSHGLFKKLGVPGPRPLPLFGNVLSYRK (0)
GVCEFDEECFKKYGKMWG (2)
IFEGKHPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPMGVMKNAVSVAEDEQWKRIRTLLSPTITSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDMKE (2)
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILDPFLLSV (1)
VLFPFLIPIFEVLNISIFPKSAVNFLTTSVKKIKESRLKDTQK (0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAVRLERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPELEEFRLER (2)
FSKKNKDSISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQ (0)
IPLKIKSQGLLRPEKPIFLKVVLRDETISGA*
CYP3A76-ie6b Bos taurus (cow)
See cattle page for details
extra exon 6 SCAFFOLD300381 other exon 6 at 7654
9898 MFPIIGKYGDVLVRNLRKEAEKGKSVNMKE
CYP3A77 Alligator mississippiensis (alligator)
GenEMBL AB186129
Satomi Kohno
Submitted to nomenclature committee Aug. 18, 2005
54% to 3A48 Fugu, 57% to 3A27 trout, 61% to 3A5 human
62% to ball python CYP3A42
clone name CYP3A_AA
CYP3A78 Phascolarctos cinereus (koala, marsupial)
No accession number
Ross McKinnon
Submitted to nomenclature committee July 29, 2005
56% TO 3A4 AND 3A5, 77% TO OPOSSUM 3A (UNNAMED)
CYP3A79 Mediterranean sea bass
GenEMBL DQ268535 not yet available on Jan 4, 2006
Pier Giovanni Gervasi
Submitted to nomenclature committee Dec. 14, 2005
CYP3A80 Gallus gallus (chicken)
GenEMBL XM_414782
Note: chicken has two CYP3As about 25kb apart on chr 14
See CYP3A37
MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPL
PFLGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTF
TNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNI
EKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNP
LLIFIVLFPFMIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMI
DSQSSQDSSKSAREKDSYKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKRLQDEIDANLPNKAAPTYNVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNG
VTIPKDMVVMIPAYVLHRDPAYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCI
GMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHSDP
QN
CYP3A80 Meleagris gallopavo (turkey)
No accession number
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F2
90% to chicken 3A80 probable ortholog
CYP3A80 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80049345-80104701
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mdo1
63% to CYP80A1 chicken (ortholog)
MTSYSGLSTETWTLLVAFVTLLILYGIWPYGIFKKLGIPGPRPLPFFGTFLEYRKGILEFDKQCFQKYGKMWGFYDGRLPIL
AILDPDIIKIVLVKEFYTLFTNRRNFGLNGILDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKV
AQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKMNLSLLSKENI
DFLVNASRRIIADRKKSNSRDRVDFLQLMIDSQVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLA
THPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQKTAEINGITIPKGTVMLIPVYVLHHD
PEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPK
KPIILKLVPRPRPDVED
CYP3A81 Xenopus tropicalis
See Xenopus pages for seq
UCSC Browser scaffold_76:65898-87839 Aug. 2005 (xenTro2) assembly
NM_001015786.1 59% to 3A5 from refseq database
94% to 3A125, 92% to 3A122, 91% to 3A82, 88% to 3A123
MNLIPHLSTGTWILLAALLVLILLYGIWPYGYFKKMGIPGPTPL
PFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNF
TNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNI
QGYVEKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSP
LLILVVIFPFLRPILEGLNLNFVPKDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMM
DSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYETTSTALSYLFYNLATHPDVQQRL
HEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSKQNVEINGVSIP
KGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPFGDGPRNCIGLRF
ALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSRAAAHE
CYP3A82 Xenopus tropicalis
UCSC Browser scaffold_1918:6381-20049 Aug. 2005 (xenTro2) assembly
BX779027 CX415432.1 93% to 3A81 N. Abdletawab
CX415433 = mate pair
Trace archive 243619963 419527443 418746304
476067541 (exon 1)
416306382 joint before I-helix
98% to 3A122 (different scaffold, possible allele), 91% to 3A81,
89% to 3A123, 89% to 3A125
MNLIPHLSTGTWILLAVLLVLILL (2)
YGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR
MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPLESAITVAEDEQWKRIR
SVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDVITSTSFS
VNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFM
NAVTSFREKRKKGDHS (0)
GRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTALSYLF
YNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK
QNVEINGVIIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLPFGDG
PRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSRAAAHE*
CYP3A83 Xenopus tropicalis
CX982440.1 DT453227
UCSC Browser scaffold_320:299565-317579 Aug. 2005 (xenTro2) assembly
60% to 3A80 chicken, 56% to 3A81 57% to 3A82
96% to 3A120, 91% to 3A121, 89% to 3A124
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYKLFKRYGIPGPTPIPFIGTFL
GNRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLS
GPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNKEPLD
MKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVP
LLDKMNFCFLSLKILNFFKDAVASIKKKRQKGTH
EDRVDFLQLMVDAQSNEGKSVPEEEKHGYKE
LSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDA
LMKMEYMDMVINESLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHLNPEIWP
EPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCK
DTPVPLKICTKGYLKPTKPIILNLIPKVGQTVEE*
CYP3A84P dog pseudogene between SDK1 and FOXK1
UCSC browser chr 6
The human pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
are in a syntenic location with this pseudogene
16005702-16005782 (+) strand aa 47-73 exon 1
ISNTCCFLQGFCDFDEKCFRKYARTWG
16125771-16125865 (-) strand aa 74-105 exon 2
IIYRGRQPVLVILGSLLFMRVLVKEFYILFTNR
16124466-16124555 (-) strand 112-141 exon 5
XXXXXXGSLESSLIFAKGDKWNWLRTVISWTFASGK
16119415-16119480 (-) strand 177-198 exon 7
GAFSRDVIISISFGVEADPISN
16044198-16044386 (+) strand 219-277
LFLSTIVFTFPALLLKLLNVIQLPKEGQEFFIGSISKMERKASERNLHSKQGLLVEKRQMFLN
16113643-16113882 (-) strand aa 332-419 exon 11
IQEPLHKCLSLQQAAPTCEVLLQVEYLVTV*MTPSGSTSRGMSGRVWKKT
PEGMLVMITIYRLLRHPMHWLEPEESCPER
Cyp3a85-ps rat
GenEMBL NW_001084671.1 4655562-4666355 (-) strand
86% to 3A2 new gene
(numbering is relative, taken from a larger sequence)
missing first four exons on two different contigs
67133 DLGPLGIMSKAITFSKVEEWKRYRAFLSPTFTSGKLKE 67020
66942 MFPIVEQHGDILVKYLRREDEKGKPAPVKQ 66853
VFGAYSMDEITSTSFGVSVD 66373
66372 FLTNPKDTFVEKTKKLLRFDFFDPLFLSVG
63877 LFPFLTPIYEMLNICMFPKDSIAFLQKFVYRMKETRLDSKHK
62887 HRVDFLQLMLNAHNNSKDEVSHK 62819
60567 ALSDVEIIAQSVTFIFAGYEITSSTLSFVLYSLATYPDIQKKLQEEIDGALPNK 60406
58571 APPTYDIVMEMEYLDMVLNETLRLYPVGNRLERVCKKDIELGGVFIPKGSVV 58416
58415 MIPTYPLQRDPQHWTEPEEFHPER 58344
56749 FSKENKGSIDPYVFLPFGHGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ 56588
53720 IPLKLSIQAILEPEKAIVLKVVPWDAVITGA 53628
CYP3A86 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A87
intestine
CYP3A87 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A86
liver
CYP3A88X Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
86% TO 3A22 AND 3A39v1, 76% to human 3A4 and 3A5
partial seq.
name changed to CYP3A46 after whole sequence known
CYP3A88X Sus scrofa (miniature pig)
3 aa diffs to CB479861.1 EST, probably the same seq.
F22946.1 extends seq toward N-term.
AJ959509.1 overlaps F22946 with 1 aa diff in 42
Be aware this may be a hybrid of two or more gene sequences.
BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
DB799225.1
92% to 3A39v1
name changed to CYP3A46
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*
CYP3A89 horse
No accession number
Heather Knych
Submitted to nomenclature committee June 22, 2007
79% to 3A74 cow, 80% to CYP3A4 and CYP3A5 human
80% to CYP3A39v1 pig
CYP3A89 horse
UCSC Browser chrUn:228948991-228982779, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca2
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYHKGIWDFDKKCFEKYGKMWGTYHGTKPVL
AITDPDMIKTVLVKECYSVFTNRRPFGPFGFMKSAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPILGQYGDVLVRNLKKEA
EKGKPITLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLFSFDFLDPLLLSITLFPFLNAVFEVLNVFVFPKSVT
DFFIKSVKRMKESRLKDKEKHRVDFLQLMINSQNSKELDTHKALSDLELVAQSIIFIFAGYETTSSSLSFLMYFLATHPDVQ
QKLQEEIDVTFPNKAPPTYDALVQMEYLDMVLNESLRLFPIAVRLERVCKKDVEINGVFIPKGTVVMVPTFALHKHPEFWPE
PEEFRPERFSKENKDSINPYIYLPFGAGPRNCIGMRFALMNMKLALVRMLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVSGA
CYP3A90 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5a
87% to 3A5 human, paralog of CYP3A5
CYP3A91 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga1
82% to 3A92, 79% to 3A98 dog, 79% to 3A4 human, 78% to 3A5 human
CYP3A92 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga2
82% to 3A5 human, 83% to 3A4 human,
82% to 3A91, 80% to 3A98 dog
CYP3A93 horse
UCSC Browser chrUn:228891415-228923288, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca1
MDLIPSFSTETWVLLATSLVLIYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYRKGIWNFDRKCFKKYGKMWGVYDGRRPVL
AVTDPDMIKTVLVKECYSVFTNRRPFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLMVLFPFLQPIFEVLNISLFPKSAI
DFFTKSVKRMKESRLKDKDKHRVDFLQLMINSQNSKELDTHKGLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQ
QKLQEEIDAIFPNKAPPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFSLHRASEFWPE
PEEFRPERFSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVNGA
CYP3A93 horse
AAWR02042202.1 (+) strand
WGS section of NCBI
79% to CYP3A5
23223 MDLIPSFSTETWVLLATSLVLIYL (2) 23294
27388 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK (0) 27480
29587 GIWNFDRKCFKKYGKMWG (2) 29640
30212 VYDGRRPVLAITDPDMIKTVLVKECYSVFTNRR (0) 30310
35597 PFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKE (0) 35710
35974 MFPIIGQYGDVLVRNLRKEAEKGKPVTLKD (1) 36063
37396 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLM 37542
40831 IVLFPFLQPIFEVLNISLFPKSAIDFFAKSVKRMKESRLKDKDK 40962
42047 HRVDFLQLMINSQNSKELDTHK 42112
45520 GLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQQKLQEEIDAIFPNK 45681
46292 APPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFS 46465
46466 LHRASEFWPEPEEFRPER 46519
52681 FSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQ 52842
54999 IPLKLGNQGLLQPQKPIVLKVESRDGTVNGA* 55094
CYP3A94 horse
UCSC Browser chrUn:229025212-229061564, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca3
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYLKGFWDFDKKCFKKYGSMWGIYDGPQPVL
AITDPDMIKTVLVKECYSVFTNRRSLGPVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKET
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSITLFPFLKAVFEVIHIYMFPKRVT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQDEIDVTFPNKALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFILHRASEFWPE
PEEFCPERFSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKIGNQGLIQPQKPIVLK
VESRDGTWNGA
CYP3A94 horse
AAWR02042203.1 78309-114672 (+) strand
WGS section of NCBI
78309 MDLIPSFSMETWVLLATSLVLLYL (2)
82015 YGTYTHGLFKKLGIPGPTPLPFLGTVLGYLK (0) 82107
84003 GFWDFDKKCFKKYGSMWG (2) 84056
84650 IYDGPQPVLAITDPDMIKTVLVKECYSVFTNRR (0) 84745
88583 PVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKE (0) 88687
88948 MFPIIGQYGDVLVRNLRKETEKGKPVTLKN (2) 89037
90379 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSI (1) 90525
95603 TLFPFLKAVFEVIHIYMFPKRVTDFFTKSVKRMKESRLKDKQK (0) 95731
96393 HRVDFLQLMINSQNSKEMDTHK (1) 96458
99613 ALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQQKLQDEIDVTFPNK (0) 99774
109466 ALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFI 109639
109640 LHRASEFWPEPEEFCPER 109683 (2)
112163 FSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0) 112324
114577 IPLKIGNQGLIQPQKPIVLKVESRDGTWNGA* 114672
CYP3A95 horse
UCSC Browser chrUn:229104699-229137172, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca4
MDLIPSLSMETWVLLATSLVLLYLYGTYSHGHFKKLGIPGPTPLPFFGTVLGYIKGVLAFDKKCFKKYGKMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKPITMKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSILFFPFLIPVYEALNIFVFPKCVT
DFFIKSVKKMKESRLKDKAKQRVDFLQLMINSQNSKEIDNLKVLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQ
QKLQEEIDATFPNKAPPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVLHQHPEFWSE
PEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQIPLKLVSQGLIRPEKPIVLK
VESRDGTMSGA
CYP3A95 horse
AAWR02042203.1 157804-190276 (+) strand
WGS section of NCBI
157804 MDLIPSLSMETWVLLATSLVLLYL 157875 (2)
161963 YGTYSHGHFKKLGIPGPTPLPFFGTVLGYIK 162055 (0)
163958 GVLAFDKKCFKKYGKMWG 164011 (2)
168704 FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR 168802 (0)
172355 SFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKE 172468 (0)
172730 MFPIIGQYGDMLVRNLRKEAEKGKPITMKE 172819 (2)
174148 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSI 174294 (1)
178624 LFFPFLIPVYEALNIFVFPKCVTDFFIKSVKKMKESRLKDKAK 178752 (0)
179820 QRVDFLQLMINSQNSKEIDNLK 179885 (1)
183504 VLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQQKLQEEIDATFPNK 183665 (0)
186095 APPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVL 186271
186272 HQHPEFWSEPEEFRPER 186322 (2)
187860 FSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQ 188021 (0)
190184 IPLKLVSQGLIRPEKPIVLKVESRDGTMSGA* 190279
CYP3A96 horse
UCSC Browser chrUn:229197172-229225636, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca5
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGFDTECLKKYRKMWGFYDGRQPVL
AITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEA
EKGKPIALKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFLFPKSVT
DFFTKSVKRIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQ
QKLQEEIDATFPNMAPPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFALHRDTELWPQ
PEEFHPERFSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQIPLKLVTYGFLQPEKPIVLK
VESRAGTVSGA
CYP3A96 horse
No accession number
Heather Knych
Submitted to nomenclature committee Jan. 30, 2009
Equine CYP450 Proposed Sequence 47
72% to CYP3A4, lower case region out of frame
77% to CYP3A4, 84% TO CYP3A89 if frame restored
note: this seq has 12 diffs to the genomic sequence
5 diffs are in the frameshifted region
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGF
DTECLKKYRKMWGFYDGRQPVLAITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISI
SEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEAEKGKPIALKDIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFL
FPKSVTDFFTKSVKGIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
IFIFAGYEpsavlfflfcifwpltlmssrscrrrlmqlppiwhlPTYDALVQMEYLDMVL
NESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFVLHRDTELWPQPEEFHPERFS
KENKDSINLYIYMPFGNGPRNCIGMRFVLMNMKVAVVRVLQNFSFNPCKETQIPLKLVTY
GFFHPEKPIVLKVESRAGTVSGA*
More P450-like translation of the lower case region
XSSSLLSFLYLLATHPDVQQKLQEEIDATSPNMAP
CYP3A96 horse
AAWR02042203.1 250268-278726 (+) strand
WGS section of NCBI
250268 MDLIPSFSVETWVLLATSLALLYL (2) 250339
253991 YGIYTHGLFKKLGIPGPKPLPFLGTLLGYRK (0) 254083
256253 GFGGFDTECLKKYRKMWG (2) 256306
256882 FYDGRQPVLAITDPDLIKTVLVKECYSVFTNRR (0) 256980
260533 SFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKE (0)
260908 MFPIIGQYGDVLVRNLKKEAEKGKPIALKD (2) 260997
262303 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSI (1) 262449
267216 TIFPFLNPVFELLNIFLFPKSVTDFFTKSVKRIKESRLKDKEK (0) 267344
268416 QRVDFLQLMINSQNSKEMDTHK (1) 268481
271703 ALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQQKLQEEIDATFPNM (0) 271864
274219 APPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFA 274392
274393 LHRDTELWPQPEEFHPER (2) 274446
275949 FSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQ (0) 276114
278634 IPLKLVTYGFLQPEKPIVLKVESRAGTVSGA* 278729
CYP3A97 horse
UCSC Browser chrUn:229268263-229304613, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca6
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDFDKKCFKKYGKTWGFYEGRLPVL
AITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAIIRSEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEA
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISVFPKSVT
DFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQKEIDVTFPNKVPPTYDALLQMDYLDMVLNESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPE
PEEFRPERFSKENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTEAIVKPQKPIVLK
VEPRDGTMTGA
CYP3A97 horse
No accession number
Heather Knych
Submitted to nomenclature committee Feb. 16, 2009
Equine CYP450 Proposed Sequence 43
85% TO CYP3A89, 76% to seq 47, 75% to CYP3A5
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDF
DKKCFKKYGKTWGFYEGRLPVLAITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAITR
SEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEAEKGKPVTLKNIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISV
FPKSVTDFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
VFIFAGYETTSTSLSFLMYLLATHPDVQQKLQKEIDVTFPNKVPPTYDALLQMDYLDMVL
NESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPEPEEFRPERFS
KENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTE
AIVKPQKPIVLKVEPRDGTVTGA*
CYP3A98 Canis familiaris (dog)
XP_536868.2 GenPept
95% to CYP3A12, 91% to 3A26
MDLIPSFSMETWLLLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGFSVFDENCFRKYGRMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENIKKLLKFDFLDPFFFSILLFPFLTPVFEVLNIWLFPKSVT
DFFTKSVKRMKENRLKDKQKHRVDFLQLMINSQNSKETDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQ
QKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE
PEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLK
VEPRDGSVNGA
CYP3A99 Canis familiaris (dog)
XP_546969.2 GenPept
95% to seq a + f from dog page, (exons 10, 11 do not match)
87% to 3A12, 85% to 3A26
MDLIPSFSTETWLLLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGFCDFDEKCFRKYGRMWGFYDGRQPVL
AIMDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSIILFPFLTPLYEMLNIWLFPKKIT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMNTHKALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQ
QKLQKEIDATFPNKAAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE
PEKFQPERFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILN
VEPRDGSVRGA
CYP3A100 Bos taurus (cattle)
XP_584699.3 GenPept
95% to 3A74, 91% to 3A76, 80% to 3A28
MELIPSFSMETWVLLSISLVLLYLYGTYSHGLFKKLGVPGPRPLPYFGNVLSYRKGVCEFDEECFKKYGKMWGIFEGKHPLL
VITDPDVIKTVLVKECYSVFTNRKVFGPRGIMKNAVSVAEDEQWKRIRTLLSPAFTSGKLKEMFPIIGKYGDVLVRNLRKEA
EKGKSVNMKEVFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSVVLFPFLVPILDVLNITIFPKSAV
NFFTKSVKRIKESRLKDNQKPRVDFLQLMINSQNSKETDNHKALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQ
QKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE
PEEFRPERFSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLK
VVLRDGTISGA
CYP3A101 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80414036-80431004
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo2
89% to CYP3A102, 89% to 3A104, 89% to 3A103, 88% to 3A105, 69% to 3A89
IFTLPYRYGTRTHKLFKNLGIPGPTPLPFIGTVLSYHKGIEGFDYGCFKKYGKTWGFFDGTKPVLAIMDPETIKTVMVKECY
SVFTNRRMLGLSGILEKAISIAEDEQWKRMRTVLSPAFTGGKLKEMFPIIKQYGDVLVKNMKKEAEKSKPVTLKDILGAYSM
DVITSTSFGIHVDSLNNPNDPFVRKIRKLIRFSFRDPLILSIVIFPFLIPLFKKLDITIFSKDVTDFLAKSILKIKEERKKT
EKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYESTSSVLCFLFYQLATNPGIQEKLQKEIDAFLPNKEA
VTYDALVQMEYLDMVINENLRLYPITGRIERIAKKPVELNGLMIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKES
INPYVYLPFGVGPRNCLGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSYRPLLAPSVPIVLQAVLRNKKGNQH
CYP3A102 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80549861-80580975
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo3
90% to 3A104, 89% to 3A103, 89% to 3A105, 89% to 3A101, 80% to 3A106
MNIIPNLSAGTWTLIILFLTILYLYGTRTHKLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVL
AIMDPETIKTVLVKECYSVFTNRRMLGLSGILEKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDAT
DFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLE
IQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYW
PEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIV
LQAVLRNKKGNQH
CYP3A103 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80611887-80640626
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo4
99% to 3A105, 99% to 3A104, 89% to 3A102, 84% tpo 3A106
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A104 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80672879-80701151
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo5
99% to 3A103, 98% to 3A105, 90% to 3A102, 89% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGILEKAISIAEDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERKKSTGKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A105 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80734341-80768989
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo6
99% to 3A103, 98% to 3A104, 89% to 3A102, 88% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A106 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80783381-80814644
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo7 note: this seq has an assembly defect in the middle
85% to 3A105, 84% to 3A103
MNIIPSLSAGTWTLIVVFLTLLYLYGTRTHKLFKNLGIPGPKPLPFFGTVFSYRKGLVNFDYDCFKKYGKTWGFYDGRQPVL
ATMDPETIKTVMVKECYSVFTNRRSFGPVGSLESAITVAKDDQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKNKPVTMKDILGAYSMDVITSTSFGIHVDSLNNPNDPFVREIKKLIRFNFLDPLILSVAIFPFLTPLFNKLDITVFPKDAI
NFLAKSLISMFSTIFSALVFILHYFFQHRVDLLQLMMDSQSSKNSEPHSHKDLSDQEILAQSIIFLFAGYETTSSVLSFLFY
HLATNPEIQEKLHKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLFPIAGRVERVAKKTVELNGLTIPKGTVVMTPPYVL
HREPEYWPEPEKFHPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMNMKVAVSRLLQEFSFRTCKETQVPLKLGNQPIL
TPTIPIVLQAELRNKKTN
CYP3A107 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25769723-25784944, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan1
78% to CYP3A108, 75% to CYP3A109, 71% to CYP3A110, 57% to CYP3A113
MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGKIWRLFEGRQAMV
AVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSGKLKEMLRIMIHYGEILVKTIWKKA
EKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKLSSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSV
EYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQNPKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDV
QQKLQEEIDKVLPNKSPLTYDAIVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWT
EPDEFRPERFSKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPIVL
QFIPRADTKSQD
CYP3A108 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25741772-25760791, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan2
79% to 3A109, 78% to 3A107, 75% to CYP3A110, 56% to 3A37 chicken
MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGKIWGLYEGRQAII
AVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSGKLKEMLPIMTHYGEVLVRNIWRKA
EKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKISSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSV
EYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQNPKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDV
QEKLQAEIDTVLPNKSPLTYDALVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWL
EPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPIVL
RYIPRADTKIKD
CYP3A109 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25693551-25724066, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan3
79% to 3A108, 75% to 3A107, 77% to 3A110, 55% to CYP3A37 chicken
MSSILSFSIETWILLGTFLALMILYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKI
AVLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYGEVLVKNLQNKV
EKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALISVLPFMIPLLKLLNINTFPNDSV
EYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDV
QKKLQEEIDEVLPNKAPLTYDALVQMEYLDMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWV
NPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVL
RFIPRAEIKSKD
CYP3A110 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25660643-25688288, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan4
77% to CYP3A109, 75% to 3A108, 71% to 3A107, 56% to 3A37 chicken
MRGILNFSIETWILLGSFLTLVILYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFDKKCFQKYGKIWGFYEGWKAKI
AVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRTLISSTFTSGKLKEMVPTIIHYGEILVKNIWYKA
EKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDRFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSV
EYFKRFMDNIKGTHHQGNQQQQVNFLQMMLDTQNPKEGSKAKGVLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDV
QQKLQEEIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHREPKYWL
EPDEFHPEIPLELTARGFLIPQKPIVLQFIPRAEIKKG
CYP3A111 Ornithorhynchus anatinus (platupus)
UCSC Browser, Contig7638:3143-20297, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan5
66% to CYP3A80 opossum (possible ortholog),
63% to 3A113, 60% to 3A80 chicken
GGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDI
DSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVDFLQLM
VDSQSSDSNSEPKMTDTEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDM
VVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPR
NCIGMRFALLNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED
CYP3A112 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:62196-70979,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca1
84% to CYP3A113, 69% to CYP3A114, 66% to 3A80 chicken
62% to CYP3A80 Monodelphis domestica, 60% to 3A37 chick
MDFFSFFSIQTWSLLGIFLLLLMLYGIWPYNFFKKLGIPGPRPLPFIGTFLEYNKGVLDFDERCRQKYGKIWGFFDGRQPVM
AIMDPVIIKTILVKECYTHFTNRRDFGLNGDFDASVLVAQDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGEMLVKNVQKKG
ENGEYIDTKDIFGAYSMDVITSTSFSIDIDSINNPKDPFVVSMKKIIKTNFVNPLLLLIVIFPFLRPVLEALNISLAPTSAT
GFLRGALRKIKSDRQKNVHQDRVDFLQLMVDSQISGDVFDGTNSYKALNDREILAQAFTFVFGGYETTSSTLGYMAYCLATH
PDVQKKLQDEIDEVLPDQATPVYDALLQMEYLDMVINETLRLYPPGGRIERVCKNTVEINGVTIPKGTVAMIPAFVLHRDPE
FWPEPEEFRPERFSKENKEFLNPYVFLPFGIGPRNCIGMRFALLSLKVATVVLMQRFSFRTCKETPIPLELESKGFMRPKNP
IRLKFVPRVMAESNE
CYP3A113 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:49268-57033,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca2 Browser is missing first exon in a seq gap
84% to CYP3A112, 68% to 3A80 chicken, 72% to 3A114
61% to 3A37 chick
GIWPYNFFKKLGIPGPRPLPFIGTFLEYRKGVLDFDEMCHKKYGKIWGFFDGREPVMAILDPVIIKTILVKECYTHFTNRRD
FGLNGDFDSSILTVQDEQWKRIRTVLSPNFTSGRLKEMFPIINHYGEMLVKNIQKKVENGEYIDTKDIFGAYSMDVITSTSF
SIDIDSINNPNDPFVTNIKKIVKFNFVNPLLVLIVIFPFLTPVLEALNFSLTPTSVTNFIKESIKKLKKDRQKNLHKDRVDF
LQLMVDSQISGEILDDSKSYKALNDKEILTQAIIFVFAGYETTSSTLSYMAYCLATHPDVQQKLQEEIDEALPNQATPVYEV
LLQMEYLDMVINETLRLYPPGGRIERVCKTTVEINGVTIPKGTVTMIPAFVLHRDPEFWPEPEEFRPERFSKENKETLDPYT
FLPFGAGPRNCIGMRFALLSLKVAMIVLLQRFSFRTCEETPIPLELQSQGFMTPKKPIRLKFVPRVMAESKE
CYP3A114 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:33297-45513,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca3
72% to CYP3A113, 69% to 3A112, 61% to 3A80 chicken
58% to 3A37 chick
YGIWPYNFFKKLGIPGPRPLPFIGTLHKHRIGVNNFDQKSHEKYGKIWGLFDGRQPVIAILDPAIIKIILVKHFYTHFTNRR
DFGLNGELDTSIAITRDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGKILVESAQKKVENGEAIDLKSFFGGYSMDVTTSTS
FSINVDSINNPNDPFVMHIKTFLKFDTFDPVILLVVIFPFLRPLFERLNFNMVAPSSFTTFFIDVLKKVKKDRQKNDHKNRV
DFLQLMVDSQISGNIPEEAKMYKALTDKEILTQAIVFIFAGFETTSTTLSFLSHCLATNPDVQQKLQEEIDATLPDQATPTY
NAIQQMEYLDMVVNETLRLYPVGGRIERDCKNTVEINGVTIPKGTVIVIPTFPLHRDPEYWPEPEEFRPERFSKENKETQNP
YVYLPFGAGPRNCIGMRFALLVVKVAIVVLLQKHTLRPCKETQIPLEVHGQVLLEPKKTIKLKLVRRAGLEE
CYP3A115 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:424-21366,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca5 partial seq
54% to 3A37 chicken
YGIWPYGVFKKLGVPGPTPLPFIGTALAYRNGILQFDKACFKKYGKVWGFYDGRTPVLAVTDPAVIKAVLVKECYTVFTNRR
KFGPTGKLEKAVSLAEDDTWKRIRTVLSPTFTSGKLKEMLPIIQHYAEILIKNFSEKADKGETVDIKDVLGPYSMDVVASSS
FGVNINSMNNPQDPFVKQAKKLVKFNFFSPLFVLMYMVPWLTPVLNKMNITLFSAEAVDFFAKAIGKIKEQRKQEMDKGRVD
FLALMIESQKAEAKTQINGMNQTYKFSKENKGRIDPYVYLPFGAGPRNCIGMRFAFLILKAGAVSLLQNFTFKPCKETQIPM
ELSTTGLMIPKKPIILKAIPRASSSH
CYP3A116 Dicentrarchus labrax (European sea bass)
ABB90404.1 GenPept
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Dla3aX
Possible Ortholog of CYP3A68
87% to 3A68 bass
MGYFFYFSAETWTLLVTLITLFFVYVYWPYGTFKKMGIPGPKPIPFFGTMLAYRKGFMNFDSECFQKYGKTWGIYDGRQPVL
CITDVSMIKTVLIKECYSLFTNRRNFRLNGPLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFGIMKQHSANLISSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDLDSLNNPSDPFVTNIKKMLKFDLFSPLFLIVAFFPFMGPVFEKMEFSFFPTYVT
DFFYAALQKIKSNRETSKQKSRVDFLQLMIDSQKNNDLSGVEQDKGLNDHEILSQAMIFIFAGYETSSSSLTFLAYNLATNP
AVMKRLQQEIDSTFPNKAPIEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVELNGIVIPKDMVVMIPTWPLHRDPDL
WPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRFALVMMKLAIVEVLQRYSFSVCKETEVPFEMDIQGLLMPKRPI
KLKLEPRSEPSS
CYP3A117 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4870920-4874088, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33062
Paralog of CYP3A68
93% to 3A119, 93% to 3A118, 81% to 3A68 bass,
81% to 3A68 Dicentrarchus
MGFSLFLSAETWTLLVALVTLLFMYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFEGRQPVL
CITDPAMIKTILIKECYSLFTNRRNTRLNGQLHDALTVAENHQWRRIRSVLSPSFTSGKLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKLLNIDFFSPVFLIVAFFPFLGPIMEKMEFSLFPKSVT
DFFYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIVPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSL
WPEPEAFKPERFSKENKDSIDHYTYMPFGAGPRNCIGMRFALMMMKLAMVEILQRFSLSVCKETEIPLEMDTQAVVMPKRPI
KLKLVSR
CYP3A118 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4859354-4863677, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33063
Paralog of CYP3A68
95% to 3A119, 93% to 3A117, 83% to 3A68 bass
MGFSLFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGIPGPQPIPFFGTMLAYRKGITTFDEDCSKKYGKVWGIFDGRQPVL
CITDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDILSPLFLIVAFFPFLGPIMEKMEFSFFPKSVT
DFFYSALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIILRLERVAKATVEINGIVIPKDMVVAVPTWPLHRDPSL
WPDPEAFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVENLQRFSFSVCKETEIPLEMDVQDLLMPKRPI
KLKLVSR
CYP3A119 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4853058-4857963, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33064
Paralog of CYP3A68
95% to 3A118, 93% to 3A117, 87% to 3A68 bass,
86% to 3A68 Dicentrarchus
MGFFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFDGRQPVLCI
TDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKADK
DEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDFFSPVFLIVAFFPFMAPILEKMEFSFFPKSVTDF
FYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSSLSFLAYNLARNPHI
MKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSLWP
EPEAFKPERFSKENKDSIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVEILQRFSFSVCKETEIPLEMDVQGLLMPKRPIKL
KLVPR
CYP3A120 Xenopus tropicalis
UCSC Browser scaffold_320:325056-341660, Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3202
96% identical to CYP3A83, adjacent on chr, 90% to 3A121
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRKGLMEFDMECFKKYGKVWGIYEGQKPLL
AIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEKHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNI
ATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKP
TKPIILNLIPKAGQTVEE
CYP3A121 Xenopus tropicalis
UCSC Browser scaffold_320:348830-370189 Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3203 adjacent to CYP3A120, 91% to 3A83, 90% to 3A120, 88% to 3A124
MTFLPDFSKETWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRHGLMEFDMKCFKKYGNVWGFYDGPQPVL
AILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKMNFCFLSSKFL
KFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEEKHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNI
ARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKP
TKPIILNLVPKGAQTTEEQI
CYP3A122 Xenopus tropicalis
UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
98% to 3A82 (different scaffold, but possible allele)
92% to 3A81, 90% to 3A123, 90% to 3A125
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE
CYP3A123 Xenopus laevis
AAH60496.1 GenPept
90% to 3A122, 90% to 3A125, 89% to 3A82, 88% to CYP3A81
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE
CYP3A124 Xenopus laevis
AAH84827.1 GenPept
89% to 3A83, 89% to 3A120, 88% to 3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE
CYP3A125 Xenopus laevis
AAI29607.1 GenPept
94% to CYP3A81 (possible ortholog),
90% to 3A123, 90% to 3A122, 89% to 3A82
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE
CYP3A126 Pimephales promelas (Fathead minnow)
No accession number
Roger Meier
Submitted to nomenclature committee Dec. 29, 2007
81% to CYP3A65 Danio
CYP3A127 Gobiocypris rarus (a rare minnow)
GenEMBL EU106660 (not available yet on May 19, 2008)
Jiayin Dai
Submitted to nomenclature committee 4/19/2008
70% to trout CYP3A27
CYP3A128P horse
AAWR02042203.1 386095-397052 (+)
Pseudogene beginning with exon 8, & = frameshift
386095 AVFPFLKPVFEA*NIFLFPKSVLDFFTKSIKx & xKESRHKDKQK (0) 386222
387533 Q*VDFLQMIT & SQNSKDMDTHK (1) 387597
390790 ALSDLELVAQSIIFIFGGYEPTSSNFSFLMYALATHPDVQQKMQEEIDVTFPNK (0) 390951
395473 APPTYEVLIQMKYLDMVINESLRLFPVTFRLERVGKKDV*ISGVFITKGTVVMVPT 395640
395641 FILHRDLELWQEPEEFHPER (2) 395700
396957 MPMKFGIQGLLQPQKPTVVKVESRDGTACGL* 397052
CYP3A129 horse
AAWR02042203.1 (-) strand
WGS section of NCBI
453729 MNLIPSFSTDTWVLLATILGLLYL (2)
YGTYTHGLFKKLGIPGPTPLPFLGNVLSYRK (0)
GFWDFDKTCFKKYGKIWG (2)
445287 FYDGRQPVLAITDPEMIKTVLVKECYSLFTNRR (0)
PVGPVGILKSSITLSEDEQWKRMRTLLSPTFTSGKLKE (0)
MFPTISQYGDVLVRNLRKEAEKGMPITLKE (2)
440191 FFGAYSMDVITGISFGVNIDSLNNPQHRFVENCKNILKFHFFDPLTILL (1) 440045
ALLPFLSPVLEVLNILVFPVSAIKFFTKSIKTIKESRLKDKQK (0)
QQVDFLQLMINSQNSKEMSRYK (1)
ALSDLELVVQSISFIFAGYETTSSSLSFLTYALATHPEVQEKLQEEIDLAFPNK (0)
APPTYDALLQMDYLDMVLNENLRLFPIAVRLERVCKKNVKINGVFIPKGTVV
MVPNFLLHRDPEFWPEPEEFHPER (2)
FSKKNKDRINPYVYLPFGTGPRNCIAMRFAIMNMKLAVVKLLQNFSFKPCEETQ (0)
IPLKLCNQGLMEPQKPIVLKVEFRDRTVSGP* 420572
CYP3A130P horse
AAWR02045041.1
4 aa diffs to CYP3A93, partial sequence
this seq is on a small contig and it may continue
in the downstream region
7949 MDLIPTFSMETWVLLATSLVLVYL 8020
12115 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK 12207
14312 GISNFDRKCFKKYGKMWG 14365
CYP3A-se1[2] human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
old name = CYP3A54P
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A-se2[5] human
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
old name = CYP3A55P
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
mouse Cyp3a fragments of uncertain location
Cyp3a-se3[1] mouse
NT_039319.1
new 3a frag from 1-24 exon 1 + strand
v in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
The true location of this fragment is uncertain
14293 MEPV (frameshift) FSSLTGYEWILLAIILVLLYR 14358
Cyp3a-se4[5:6]X mouse
NT_071157.1|MmUn_71197_30
3a exons 5,6, only 3 aa diffs with 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
95% to 3a63-ps
549 EFGSVAIMSKAISISKDEECKRYRALLSPTFTSGRLKE 436
356 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 267
Cyp3a-se5[12]X mouse
NT_071987.1|MmUn_72027_30 3a exon 12
2kb genomic sequence near exon 12 has best match to 3a41a-de12b
The fragment was removed from Genbank
This was probably a poor quality version of 3a41a-de12b
12194 FIKESKGNIHPYIYLPFGNGPRN*IGMRFALLNMKLTLTKVLQNFTFQPCKETQ 12033
Cyp3a-se6[12] mouse
NT_055698.1|MmUn_55738_30 3a exon 12
5 aa diffs with 3a58-ps
identical to 3a11-de9b10b11b12b
may be the same sequence between 3a44 and 3a11
1226 FSMENKGSIDPYX 1191
1186 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQ 1064
Cyp3a-se7[8:9:10]X mouse
NT_067897.1|MmUn_67937_30 3a exon 8
NT_059425.1|MmUn_59465_30 3a exon 10
5160 bp of the genomic sequence was 98.9% to 3a-se12[8:9:10] pseudogene region
The fragment was removed from Genbank. This was probably a poor quality version of
3a-se12[8:9:10]
5042 FATFFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 4935
4933 IVERTKENCLDSKQK 4889
HQVDFLHLMINAHDNTKDNESHK
979 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLTHHDS*KNLRENDRALPNK 821
Cyp3a-se8[3]X mouse
NT_070793.1|MmUn_70833_30
1 diff to 3a11 exon 3 or 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
671 GFWKFDMECYKKYGKTWG 618
Cyp3a-se9[8]X mouse
NT_050947.1|MmUn_50987_30
2 diffs to 3a41 exon 9
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
174 HRVDFLQLMMNAHNNSKDKNSHQ 106
Cyp3a-se10[12] mouse
NT_050917.1|MmUn_50957_30
3a exon 12, 3aa diffs to 3a58-ps
521 FSMENKGSIDPYXXXXXX 486
483 NGPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQ 377
Cyp3a-se11[2]X mouse
NT_074310.1|MmUn_74350_30 3a exon 12
2 diffs to 3a16, 3a41 3a44, 3a63
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
1107 YGTLTQGLFKKQGIPGPKPLPFLGTVLNYYK 1199
Cyp3a-se12[8:9:10] mouse
NT_056284.1|MmUn_56324_30
3a exon 10
revised to add two more exons 8 and 9
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31410 MEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
Cyp3a-se13[9] mouse
Between 3a63-ps and 3a41b in UCSC browser
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b and old frag w from map
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A sheep
PIR A60728 (20 amino acids)
Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
Purification of a sheep liver cytochrome P-450 from the
P450IIIA gene subfamily. Its contribution to the
N-dealkylation of veterinary drugs.
Biochem. Pharmacol. 39, 901-909 (1990)
only one amino acid difference with CYP3A24 (L9K)
CYP3A baboon (Papio sp.)
Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
Purification of two cytochrome P450 isozymes related to CYP2A
and CYP3A gene families from monkey (baboon, Papio papio)
liver microsomes. Cross reactivity with human forms.
Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
Eur. J. Biochem. 204, 641-648 (1992)
3B Subfamily
CYP3B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213a
6382 MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232 YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052 GIIPFESWCQAEYGDVWG 5999 (2)
Exon 3 not detected may be in small seq. gap
5469 XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259 AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069 FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846 AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011 GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780 APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651 LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416 FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171 IPLEFDWKSQPLKPIKLSFIPRQK* 3097
CYP3B2 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
8214 HKDPRFWSSPEEFRPER 8164 (2)
XXXXXXXXX in sequence gap
IELGTFMX frameshift
8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734
CYP3B3 Oryzias latipes (medaka)
UCSC Browser, chr15:14900678-14906425, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola1
70% to 3B4, 67% to 3B7, 66% to 3B6, 67% to 3B1
MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNLNIPGPKPLPFVGTIFGVRKGLFAFDSECQAKYGDVWGLYDGRSPVLM
VADPEMIKTIMVKECYSVFTNRRETLIPGPFEDGITVVKDDRWKRIRSTISPCFTSGRLKQVFPIVASYADRLLKKLEQTNL
DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSEDPVNVHIQKLFNINFWPFILLMICPFAGRLLNSLNIGMLPKAESDFFL
NIIKKFKDQHKAGESTRQDFLQVMVQSEIPENEIKNEQEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHA
MHTLQKEIDANLQKNASFSYEELNDLHYLDQVILESMRVLPTAPRLERGCKKTVEIQGFTIPEGTVVGIPVMNLHKDPRYWS
SPELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLETCKDTLIPLQFDWKFQPLKPIKLKF
VPRKQ
CYP3B4 Oryzias latipes (medaka)
UCSC Browser, chr15:14910843-14918605, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola2
69% to 3B6, 70% to 3B3, 68% to 3B5, 66% to 3B7, 64% to 3B1
MFWSWFPGATWTLLALLLTILIFYGLWPYRVFKNLGISGPMPLPFVGTVPQQMKGLFAFNRECQAKYGDVWGLYEGRSPLLM
IADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMN
LNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWPMIIRMIFPLGARLLKHFKFEIIPRSSVDFF
CDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESEVKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPD
AMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQINGLTIPEGTVVGIPVHLLHRDPRFW
DSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWKFQPLKPIKLK
FVPRKR
CYP3B5 Oryzias latipes (medaka)
UCSC Browser, chr15:14921023-14926010, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola3
71% to 3B6, 68% to 3B4, 66% to 3B3, 62% to 3B7, 59% to 3B1
MLFLFSATTWTLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQQGKGFFEFDHECQTKYGDVWGVFEGRQPILMV
ADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVASAKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYL
NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQKATRFNFLPTILQSIIPFGGRLLKLFKIETLPSANVEFFI
DIIRNLKDQHKTENRPDFLQVLIESEMPDAEIKNSQQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMH
TLQKEIDSNLQKNSSISYEDLNGLEYLDQVINESLRLYPVAPRLDRECKMTVETQGFTVPEGMIVGIPVYLLHKDPRFWSSP
ELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQFNWMFQPIKPVKLKFVP
K
CYP3B6 Oryzias latipes (medaka)
UCSC Browser, chr15:14927785-14936321, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola4
69% to 3B4, 71% to 3B5, 66 to 3B3, 65^ to 3B7, 61% to 3B1
MFSATTWTLLALFFTVLLLYGVWPYRVFRKLGISGPMPLPFVGNVLQMGRDILSFDRQCLDKYGDVWGVFEGRQPMLMVANP
ELVKAVMVKECYSAFTNRRNFFPEDGPLADGVAVVKDEKWKRIRSSLTPCFTSGRLKQVYPLVARYAENLVKKLGRMNSDEP
IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPVNVQAQKATNFNFWPVILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLI
KRLRDQHKAGKLTRPDFLQVLIDSEIPQEHVKNEQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQ
KEIDSNLQNDGSFSYEELSGLEYLDQVLCESMRFFSPTPRLDRECKKTIEIHGVTIPKGTLVAIPVSLLHMDPRFWSSPEIF
RPERFSKENASELNPYAYMPFGLGPRNCVGMRFAVLVMKMVIVRLLQSYSLETCKDTLIPMQYDWQFQPIKPIKLKFVPRKQ
CYP3B7 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrVI:13967807-13971259, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac49971
68% to 3B1, 66% to 3B4
MFLFDWFPATSWTLLALFFTLLILYGIWPYRFFKNLGIKGPRPLPFIGTFLHFRKGWLSFDRECQAKYGDVWGNFDARLPVL
MVADPEIIKTVMVKECYSVFTNRRENAVPGPMGDAITAVKDERWKRIRTSLSPCFTSGRMKQVFPIVARYADRLTEKLGGMH
SVPIDVKQFMAPYSLDVVTSASFSVEANSINNPDDPLNVHLKNILNFKLWPVFILMVFPFGARLLRLLKLEMLDRVSVDYFY
DVIKHFKHQHGEDESTRADFLQVMIQNEIPDTDIKSEEDQPSKGLTEHEILSQALIFIFGGYETTSTTLTFLLYNLATNPDA
MRTLQEEIDANIPRDAPIRYEDLLGLQYLDQVLLESQRLIPTAPRLERVCKKTTQVHGLTIPKDTLVGIPVQLLHMDPRFWS
SPELFRPERFSKESGEEVNPYAYMPFGLGPRNCVGMRYAVLTMKTVLVRLLQSYNVETCKDTMIPLEFDWKAQPVQPVKLQF
VPREQ
3C Subfamily
CYP3C1 Danio rerio (zebrafish)
GenEMBL BC052130.1 dated 10/7/2003
Also submitted by Don Buhler 10/2/2003
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T,
Chung WG, Buhler DR. CYP3C1, the first member of a new cytochrome
P450 subfamily found in zebrafish (Danio rerio).
Biochem Biophys Res Commun. 2006 Feb 24;340(4):1039-46.
52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49
53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout,
54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken,
48% to 3A29 pig (47% to 50% to many mammal 3As)
3D Subfamily
CYP3D1 Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Formerly CYP3A47
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQGASP (1)
RCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3D1 Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
Formerly CYP3A69
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3D1 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4874663-4879489, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33061
76% to 3D1 bass (ortholog), 61% to 3D1 Fugu,
58% to CYP3A119, 57% to 3A68 bass
MGCLPFFSVETWILLITFICIFVIYGNWTHGIFENLGIPGPKPYTYWGTIGRHNKVYYKDDQQCAEKYGKVWGMYEFRSPML
AVMDPDMLKTILVKQCFTYFTNRRNIRLNGDLYDSVSTVEDDHWRRIRNVLTPSFTSGHIKEMFKIMKHLSSKLTASLQSKA
QNNEVVTIKDYFGAYSVDVMASCAFSVDMDSINNHSSPIIFHASRFFKFPQFVLILQGIFPVLIPLFELLGISFFSPTSTAF
FKTILAKIKAEREGSTHKNSGDFLQSMINSRTANDPSKGEKNKGSLTDHEILTQATMFMVAGYETSATTLAFLAYNLARNPE
VMKRLQEEIDSTFPNKGAVRYEELLQMEYLDSVVNESMRLYPPAGRLDRVAKKTVEIRGITIPKDMIVMIPVYALHRDPDLW
PEPEEFKPDRFSKQNKRSINPYTYLPFGTGPRNCLGMRFALVLVKLALVEVLQNYSFSVCGETEIPLTMDPGGLVGPLNPIK
LKVTTR
CYP3E1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CK326870.1, CF075781
David Drane
3clan 38% CYP3A22 pig
N-term only
MWLAWLIGIVTALS
AYYIIAARRKFEYWQKKGVPGPRPWPLVGVFVQTVRMGQGFYDVWATKQFGRMFGYFDGS
QPVIAVSDPEMLRSIMVKDFPQFINRRDVDINGPLLEQAVSVLHGQKWKDVRSTLVPTFT
SGRLKQMNGLINECCDNLVSNLEKKADADEEFECQSLFRSVTMDVIASTFFG
4A Subfamily
CYP4A1 rat
PIR S21711 (22 amino acids)
Okita, R.T. and Okita, J.R.
Characterization of a cytochrome P450 from Di(2-ethylhexyl)
phthalate-treated rats which hydroxylates fatty acids.
Arch. Biochem. Biophys. 294, 475-481 (1992)
CYP4A1 rat
Aldridge et al.
Biochem. J. 306, 473-479 (1995)
note: identification of far upstream PPAR response element.
CYP4A1 rat
GenEMBL M14972
Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
Isolation, complementary DNA sequence, and regulation of rat
hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
Identification of a new cytochrome P-450 gene family
J. Biol. Chem. 262, 801-810 (1987)
CYP4A1 rat
GenEMBL X07259
Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
Differential splicing in the 3' non-coding region of rat cytochrome
P-452 (P450 IVA1) mRNA
FEBS Lett. 236 (2), 357-361 (1988)
CYP4A1 rat
GenEMBL M33937 M57718
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A2 rat
GenEMBL M33938 M57719
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A3 rat
GenEMBL M33936
Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
coordinate and tissue-specific regulation of the CYP4A genes
DNA 8, 517-525 (1989)
CYP4A4 rabbit
GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
PIR S32423 (64 amino acids)
Palmer,C.N., Griffin,K.J. and Johnson,E.F.
Rabbit prostaglandin omega-hydroxylase (CYP4A4):
Gene structure and expression.
Arch. Biochem. Biophys. 300, 670-676 (1993)
Note: The translation is different from the 4A4 sequence
in the alignment after AALLG. A frameshift occurs between
nucleotides 1201 and 1203, with an extra "G" added. After 1320
P450 similarity stops. 1320-1378 is an intron sequence.
CYP4A4 rabbit
PIR JN0089 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A4 rabbit
GenEMBL J02818
Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
and Kusunose,M.
cDNA cloning and inducible expression during pregnancy of the mRNA
for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
P-450p-2)
J. Biol. Chem. 262, 13366-13371 (1987)
CYP4A5 rabbit
GenEMBL M28655
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A5 rabbit
GenEMBL X57209
Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning and expression of the mRNA for cytochrome P-450kd
which shows a fatty acid omega-hydroxylating activity
Eur. J. Biochem. 196 (3), 531-536 (1991)
CYP4A6 rabbit
PIR S23949 (510 amino acids)
Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
Characterization of a rabbit gene encoding a
clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A6 rabbit
PIR PQ0047 (20 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
CYP4A6 rabbit
GenEMBL M29531 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A6 rabbit
GenEMBL M28656
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A6 rabbit
GenEMBL L04755
Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
Characterization of a rabbit gene encoding a clofibrate-inducible
fatty acid omega-hydroxylase: CYP4A6
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A7 rabbit
PIR JN0090 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A7 rabbit
GenEMBL M29530 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A7 rabbit
GenEMBL M28657
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A8 rat
PIR S08300 (15 amino acids)
Imaoka, S., Nagashima, K. and Funae, Y.
Characterization of three cytochrome P450s purified from
renal microsomes of untreated male rats and comparison with
human renal cytochrome P450.
Arch. Biochem. Biophys. 276, 473-480 (1990)
CYP4A8v1 rat
GenEMBL M37828
Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
Cloning and characterization of a novel member of the cytochrome
P450 subfamily IVA in rat prostate
DNA Cell Biol. 9 (8), 569-577 (1990)
CYP4A8v2 rat
UCSC browser
This is the best match to M37828, but there are some differences
especially in exon 6 (9aa diffs)
97% TO 4A8v1 M37828 chr5:135553023-135583411 (- strand) BC081771
CK483390.1 AGENCOURT EST matches
135583411 MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHK 135583223 (0)
135581811 IPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS 135581671 (1)
135581054 DPKSHHSYRFLAPWI 135581010 (1)
135580577 GYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIML 135580449 (0)
135558913 DKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDR 135558788 (2)
135558475 KYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 135558323 (1)
135557899 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135557792 (0)
135557703 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135557512 (2)
135557411 DDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK 135557280 (1)
135556361 GITVMLSFYGLHHNPTVWPNPE 135556296 (0)
135556143 VFDPYRFAPESSRHSHSFLPFSGGAR 135556066 (2)
135553187 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ 135553023
CYP4A8v2-de1b rat
UCSC browser
CYP4A exon 1 pseudogene chr5:135545150-135545338 (- strand)
Frag a in fig. below
135545338 MSIFELSHITTGFGISGLLQMVSWLGLLLLLLFKAAQYYLHRQWIIKSVQHFPSPPSHWFFGN 135545150
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de5c6c12c rat
UCSC browser (upper line is the new sequence)
135596695-135596537 (- strand) C exon 5
Frag b in fig. below
Query: 37481 SVLLPQNKWE*TISDS---LEIFQCASLITLATILMCVFSY*DNVHLNRSVTSQSF 37639
SV + +KWE + D LEIF SL+TL T++ C FS+ +V L+ V S+S+
Sbjct: 159 SVSIMLDKWE-KLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 211
135596212-135596066 (- strand) D exon 6
Query: 37964 HSQTYTQVVGILNNL-----RNAFPQSDIFYRMTADGHRTKNAFLIAHKHSDFV 38110
+S++YT+ V LNNL R+AF + I Y M++DG ++ A IAH+H+D V
Sbjct: 207 NSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 260
135594009-135593884 (- strand) E exon 12
Query: 40167 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 40292
KQF MNE+KV + LTLL FE L DPTR+ V + +L + G
Sbjct: 454 KQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNG 495
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de4d12d rat
UCSC browser (upper line is the new sequence)
135628319-135628215 (- strand) A exon 4
51% to 4A8
Frag c in fig. below
Query: 5857 LSNDQTWFQHY*HI*TPLLHCDILKSNVRIVADCI 5961
L N + WFQH + TP H DILK V+I+AD +
Sbjct: 127 LLNGKKWFQHR-RMLTPAFHYDILKPYVKIMADSV 160
135617441-135617274 (- strand) B exon 12
75% to 4A2 76% to 4A8
Query: 16735 RICIGKQLAMNAQKLAVALTLLQFELLPDPTRVPIPTEKLVLKSKNGIHLHLRKLQ 16902
R CIGKQ AMN K+AVALTLL+FELLPDPTR+P+P +LVLKSKNGIHL L+KL+
Sbjct: 449 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR 504
human, mouse and rat 4ABXZ clusters
Cyp4a10 mouse
GenEMBL X69296 (1887bp)
Colin J. Henderson, Theo Bammler & C. Roland Wolf
Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a
protein: developmental and hormonal regulation in liver and kidney
Biochim. Biophys. Acta (1994) 1200, 182-190
Cyp4a10 mouse
GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
GenEMBL Y10221 (exons 10-12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a10 mouse
GenEMBL AB018421
Yasumura,N. and Ikeda,T.
Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
Unpublished (1998)
Cyp4a10 mouse
GenEMBL NT_039264.1 + strand
15663999 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHE 15664187
15665307 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15665450
15665928 DPKANGAYRLLAPWI 15665972
15666744 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15666872
15669925 DKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVD 15670047
15670403 NYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHT 15670555
15670978 DGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFAR 15671085
15671175 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITW 15671366
15671463 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15671594
15674911 GVQVTLSIYGLHHNPKVWPNPE 15674976
15675119 VFDPSRFAPDSPRHSHSFLPFSGGA 15675193
15678206 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH* 15678376
CYP4A11 human
GenEMBL L04751 (2576bp)
PIR S29845 (519 amino acids)
Palmer,C.N., Richardson,T.H., Griffin,K.J., Hsu,M.-H.,
Muerhoff,A.S., Clark,J.E. and Johnson,E.F.
Characterization of a cDNA encoding a human kidney,
cytochome P450 4A fatty acid omega-hydroxylase and the
cognate enzyme expressed in Escherichia coli.
Biochim. Biophys. Acta 1172, 161-166 (1993)
CYP4A11 human
GenEMBL X71480 (423bp) PIR S35609 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
CYP4A11 human
GenEMBL S67580 (2470bp) and S67581 (2469bp)
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of
CYP4A11, a fatty acid omega-hydroxylase expressed in human
kidney.
DNA Cell Biol. 12, 893-899 (1993)
GenEMBL NM_000778
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a
fatty acid omega-hydroxylase expressed in human kidney
DNA Cell Biol. 12, 893-899 (1993)
CYP4A11 human
GenEMBL D26481 (2382bp) PIR JX0331, PC2194 (519 amino acids)
Kawashima,H., Kusunose,E., Kikuta,Y., Kinoshita,H., Tanaka,S.,
Yamamoto,S., Kishimoto,T. and Kusunose,M.
Purification and cDNA cloning of human liver CYP4A fatty acid
omega hydroxylase.
J. Biochem. 116, 74-80 (1994)
CYP4A11 human kidney
GenEMBL D13705 (1809bp)
Kikuta,Y.
unpublished (1994)
P-450 HVK, fatty acid omega hydroxylase
CYP4A11 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4A11_24C2
95% to CYP4A11 human 92% to 4A22
CYP4A11 Macaca mulatta (rhesus monkey)
94% to human 4A11
MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLFGHKQE (0)
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS (1)
DPKSQDPYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML (0)
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK (1)
GITVMLSIYGLHHNPKVWPNPE (0)
VFDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
Cyp4a12a mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee 12/4/96 fax
complete sequence 4aVJ2
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNDLVFSRVRNIFHLNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKELQ
Cyp4a12a mouse
GenEMBL Y10222 (exon 12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a12a mouse
GenEMBL X71479, Y10222 EST AA882070 vx36a01.r1 no UNIGENE entry
NT_039264.1
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHK
ILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRS
DPKANGSYRFLAPWIG
RGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVML
DKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRK
YKSYIQAVEDLNDLVFSRVRNIFH(Q)NDIIYRVSSNGCKANSACKLAHDHT
DQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFAR
MENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITW
NDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKG
IHVMLSFYGLHHNPTVWPNPE
VFDPSRFAPGSSRHSHSFLPFSGGA
RNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ*
Cyp4a12a-de5b mouse
GenEMBL NT_039264.1 + strand, exon 5
x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15432755 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15432907
cyp4a12b mouse
GenEMBL X71479 (423bp) PIR S35610 (141 amino acids) NM_172306
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
PCR fragment
NM_172306 97% identical to Cyp4a12a 11 diffs
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ
Cyp4a12b-de2b5b mouse
GenEMBL NT_039264.1 + strand
exons 2,5
w in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15541025 LLVYDPD*VTLILGRA 15541072
15544976 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15545128
CYP4A13 Cavia cobaya (guinea pig)
GenEMBL X71481 (423bp)
PIR S32714 (141 amino acids) PIR S35611 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
Cyp4a14 mouse
GenEMBL Y11639 to Y11642 exons 1-12
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Cyp4a14 mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee
complete sequence
Cyp4a14 mouse
GenEMBL NT_039264.1 - strand also Y11638 NM_007822
15641790 MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGH 15641605
15640707 LFPKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRS 15640564
15639891 DPKASGIYQFFAPWI 15639847
15639380 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIML 15639252
15638411 DKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLD 15638289
15637911 NSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHT 15637759
15637345 DGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFAR 15637238
15637154 MEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVT 15636966
15636875 DHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPK 15636744
15635704 GITATISIYGLHHNPRFWPNK 15635639
15635542 VFDPSRFAPDSSHHSHAYLPFSGGS 15635468
15632990 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR* 15632820
CYP4A15 Phascolarctos cinereus (koala)
No accession number
Ieva Stupans
Submitted to nomenclature committee Oct. 20, 1999
69% identical to human 4A11
CYP4A16 Felis cattus (domestic cat)
GenEMBL U91787
Gebremedhin,D.G., Lange,A.R., Narayanan,J., Aebly,M., Jacobs,E. and
Harder,D.R.
Cerebral vascular smooth muscle cells express cytochrome P450 4A2
enzyme and produces 20-HETE which enhances L-type calcium current
Unpublished
CYP4A17 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4ai 90% to mouse Cyp4a10 95% to 4A19
CYP4A18 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aii 88% to rat CYP4A1 88% to 4A19
CYP4A19 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aiii 92% to rat CYP4A1 95% to 4A17
CYP4A20X human
GenEMBL AJ131016 AC026935 161971-176942
Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
Full length seq now available on genomic DNA
52% to 4A11 52% to 4X1
because the sequence is the same percent identity to
4A11 and 4X1 and this is less than 55%
and the sequence does not cluster with CYP4As on a tree
the earlier name of CYP4Z1 is being resurrected.
This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDRS
SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
HLEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV
CYP4A21 pig
GenEMBL AJ278474
Lundell K, Hansson R, Wikvall K.
Cloning and expression of a pig liver taurochenodeoxycholic acid
6 alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily.
J Biol Chem. 276, 9606-12 (2001)
77% to rabbit 4A6
submitted to nomenclature committee July 3, 2000
This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid
CYP4A21 pig
NM_214425, AJ586859
MTVPALASVSGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQMWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSQSYIQAIWDL
KNLIFSRLRSAFLQNDIIYRLSPEGRQCQRACQKVHQHTDRVIQLRKTHLQKEGEMEN
VKKKRHLDFLDILLFARMENGNSLSDTDVRAEVDTFMAAGHDSTASGISWVLYALASN
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPSVGRELSKPIT
FPDGRSLPAGIILSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVVVALTLLRFELAPDPSRIPVPIQGIVLKSKNGIHLNLRKIP
CYP4A22 human
GenEMBL AL390073.5, AF208532 AL135960 all genomic sequences
new 4A11 like genomic sequence 95% identical to 4A11
three different gene sequences agree
so this gene is different from 4A11
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*
Also AF208532
Homo sapiens fatty acid omega-hydroxylase CYP4A11 like gene, complete cds
CDS join(2564..2758,5858..5999,6649..6693,7186..7313,
8347..8471,8840..8994,9435..9541,9628..9818,9915..10048,
10944..11008,11155..11231,13680..13875)
also AL135960 matches new 4A gene not 4A11 gene
Human DNA sequence from clone RP1-18D14 on chromosome 1 Contains genes for SIL (TAL1
(SCL) interrupting locus ), TAL1 (T-cell acute lymphocytic leukemia 1), 17 KD membrane associated protein (DD96 protein), CYP4A11 -like gene
gi|6635875|emb|AL135960.1|AL135960[6635875]
CDS complement(join(129154..129349,131798..131874,
132021..132085,132981..133147,133211..133401,
133488..133594,134035..134189,134558..134682,
135716..135843,136336..136380,137030..137171,
140271..140465))
CYP4A23 pig
GenEMBL AF384031
Van Es,A., Calleja,C. and Galtier,P.
Cloning of a new member of the cyp4a subfamily in the pig renal
cell line LLC-PK1
Unpublished
Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene
CYP4A23 pig
NM_214424.1
MTVPALASVSGPLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSDPKTSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSVQTDGDSHSYIQAIWDL
KNLFSTRTKSAFLQNDIIYRLSPEGHKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLAQMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLFIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPIATPEVVLNSKNGIHLKLRKLP
CYP4A24 pig
GenEMBL AJ318096
Kerstin Lundell
97% to pig 4A25, 97% to pig 4A23 AF384031, 90% to pig 4A21 AJ278474
77% to rabbit 4A6, 75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being
alleles of the same gene
CYP4A24 pig
AJ586619, NM_214424
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQFPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACALWRWGTRAMVLVYDPDYMKVVLARSDPKNSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPITFPDGRSLPAGITLSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRNCIGKQFAMNEMKVAVALTLLRFELAPD
CYP4A25 pig
GenEMBL AJ318097
Kerstin Lundell
97% to pig 4A24, 96% to pig 4A23, 91% to pig 4A21, 78 % to rabbit 4a6,
75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being
alleles of the same gene
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDL
KNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLSVYSLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPTVIPEVVLHSKNGIHLKLRKLP
CYP4A26PX human
AL731892.5
76% to 4A11 C-term upstream of 4A11
new name = CYP4A-se1[12]
TCIGKKFAMNEL 135092
135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105
CYP4A27PX human
AL731892.5
67% to 4A11 C-term
new name = CYP4A-se3[12]
168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322
Cyp4a28p mouse
AJ297131 also on NT_039264.1, NT_039685.1
lower case = 4a10, same contig as 4x1
4.112000001-113000000 from Ensembl mouse version 3 chr 4 add 112 million to numbers
943832 MSISALSPTRFLECVSGFLQVVSLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 943647
939707 QFKEDEELRWVLRYVEKFPSAFLHWIWGN 939621 frameshift
939621 *VFIKIYDPDYMKVILGRA 939565
939009 SDPKAGLYRFLTPWL 938965
938111 GHGLFILNGHKWFQHRRMLTSAFHYDILKPYVGTMADSVQVIL 937983
930960 DKWEQIACQDITLEIFHPISLMMLETIMKCAFSYQGSVQLDRS 930832
930514 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 930359
929925 DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 929809
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 929542
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 929424
(missing exon 10)
927997 VFDPSRFAMNSVQHSHAFLPFSGGS 927923
926387 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHL 926238
exact duplicate of exons 6-12
925899 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT
DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 925195
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 924927
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 924809
923831 IESTVSCFIFSSAWKAFDKPE
923372 VFDPSRFAMNSVQHSHAFLPFSGGS 923298
922002 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHLHLRKL 921838
Cyp4a29 mouse
4.113000001-114000000 chr 4 from mouse Ensembl version 3 add 113 million to numbers
91% to 4A28p
47095 MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 47280
53123 QFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRA 53266
53824 SDPKASLYRFLTPWL 53868
54675 GHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVML 54803
55849 EKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRS 55977
56295 RSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 56450
56880 DRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRVSS 56996
57075 DDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITW 57263
57362 DHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKG 57378
58567 IESTVSCFIFFSAWKAFDKPE
59045 VFDPSRFAMNSVQHSHAFLPFSGGS 59119
60585 RNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKL 60749
Cyp4a29-de5b6b7b9b mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4azzp
y in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15364293 QWEKII**DTTLEIFHHVSLMMLNTIIKCAFCYQGSVPLDRS 15364418
15364782 RNFQSYLQAVSYLNSIKSFCMLNLFQQNSYKLSSDGHRANCACQTVRKY 15364928
15365362 TD*VIKMRKAQQSKGSMEKLRGKR 15365433
15365704 FVGSSLLRNCIEKQLAMNVLKMDAALTLLGFD 15365799
Cyp4a29-de12b mouse
GenEMBL NT_039264.1 Cyp4axxp + strand
78% to 4a29
old temp name = Cyp4axxp
z in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15321475 KNCIVKQIAMNTLKVAVALTLLQFERLPDPTRVPIPTLQLVLI 15321603
15322479 SKNAIHLHLRKLQ* 15322520
Cyp4a30a-ps mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4aaab
missing exons 1-4
15489465 DKWEQLVGQDCPLEIYQDISLMTMETIMKCAFSYQGSVQLE 15489587
15489953 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHT 15490105
15497986 ERVICMRKAQLQNEAELEKVRKKKHLDFLDILLFAQ 15498093
15498179 TEDGKSLSDEDVRAEVDTFRFEGHDTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTW 15498370
15498472 NYLDQMPYTTMCIKEALRLYPPIPGVSREFSSPVTFPDRRSLPK 15498603
15500524 GFLVTLSFYGLHHNPRLWPNAE 15500589
15500709 VFDPSRFAPGAPWHTHAFLPFSAGTR 15500786
15508625 RNCIGKQFTMNELKVAVALTLLRFELLPDPTSVPILVLRIVLKSKNGIYLHIKKL 15508789
Cyp4a30b mouse
NT_039264.1 + strand 94% to Cyp4a30a-ps
old temp name = Cyp4aaa, also old 4ayy frags belong to this gene
LOC230640 from mouse genome
68% to 4a10
1 MSIFELSHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGN 189
1729 XFPKDQDLQQILLCVEKFPSTYVRWLWGNHARVVIYDPDYMKVILGRS 1869
2385 DPKVVRSYSFFAPWI 2429
4002 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVML 4130
5130 DKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQLE 5252
5617 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSS 5721
5723 NGRSFYHACQIAHKHT 5770
6175 ERVIRMRKAQLQNEAELEKFRKKKRLDFLDILLFAQ 6288
6374 TEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVT 6562
6666 NHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSLPK 6797
8724 GFLVTLSFYGLHHNPRLRPNAE 8789
8903 VFDPSRFAPGAPRQTHAFLPFSAGTR 8986
18305 NCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGIYLHTKKL 18472
Cyp4a31 mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4abb
15709394 MSVSALSLTRFAGSLSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHE 15709582
15710687 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15710830
15711347 DPKANGAYRLLAPWI 15711391
15712156 GYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLML 15712284
15715386 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDx 15715508 (g)
15715864 NYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQLAHDHT 15716016
15716439 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15716546
15716635 MENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITX 15716823
15716923 DHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPK 15717054
15720376 GVQVTLSIYGLHHNPKVWPNPE 15720441
15720567 VFDPSRFAPDSPRHSHSFLPFSGGA 15720641
15723611 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFVLKSKNGIYLHLKKVH* 15723781
Cyp4a32 mouse
GenEMBL NT_039264.1 + strand
15746652 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHWFFGHE 15746840
15747937 QFKGEQELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRS 15748080
15748604 DPKANGIYRLLAPWI 15748648
15752321 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15752449
15755304 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDX 15755426
15756131 NYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHT 15756283
15756698 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15756805
15756894 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITW 15757085
15757182 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15757313
15760289 GVQVTLSIYGLHHNPKVWPNPE 15760354
15760497 VFDPSRFAPDSPRHSHSFLPFSGGA 15760571
15767109 RNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHLKKLH* 15767279
CYP4A33P rat
UCSC browser exons 5-12
135689623 DKWEQIVGQDSTLEIVQHNTLMTLDTIMKCAFSQEGSVQLDR 135689766
135690074 KYKSYIKAVGDLNNLSFFRIWNIFHQNDIIYSLSSNGCQANSAC*LAHEHT 135690238
135690647 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135690760
135690855 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135691046
135691147 DDLDKMPYTTMCIKEALSIYPPVPSVSRMLSTPVTFPDGCSLPK 135691278
135692145 PKGITAVLSFYGHHHNPTL*PNPE 135692213
VFDPYRVFPXSSQHSHLFLPFSGGAR 135692425
135700661 NCIGKQFAMNELKVAIALTLLCLRLLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135700825
CYP4A33P-de4b5b12b rat
UCSC browser (upper line is the new sequence)
frag d in fig. below
135662099-135662209 (+ strand) F exon 4
Query: 9457 LSNDQTWFQH*HILTPLFHYGILKTNVRIIVDSVHEM 9347
L N + WFQH +LTP FHYGILK V+I+ DSV+ M
Sbjct: 130 LLNGKKWFQHRRMLTPAFHYGILKPYVKIMADSVNIM 166
135671387-135671512 (+ strand) G exon 5
Query: 169 DISDSLEIFQCASLIALATIMMCAFSYQDNVHLNRSVTSQSF 44
D LEIF SL+ L T+M CAFS+Q +V L+ V S+S+
Sbjct: 175 DQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 214
135676914-135677039 (+ strand) S exon 12
Query: 93402 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 93277
KQF MNE+KV + LTLL FE L DPTR+ + I +L + G
Sbjct: 458 KQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNG 499
human, mouse and rat 4ABXZ clusters
CYP4A33P-de10c11c rat
UCSC browser (upper line is the new sequence)
frag e in fig. below
135712750-135712827 (+ strand) exon 10
Query: 57566 GVLISFSICGLHHNPRLWPNAEV*NP 57489
G+ + S GLHHNP +WPN EV +P
Sbjct: 406 GITVMLSFYGLHHNPTVWPNPEVFDP 431
135713048-135713125 (+ strand) R exon 11
Query: 57271 QVFDPFRFAPDVLRHTHAFLPFSAGAR 57191
+VFDP+RFAP+ RH+H+FLPFS GAR
Sbjct: 427 EVFDPYRFAPESSRHSHSFLPFSGGAR 453
human, mouse and rat 4ABXZ clusters
CYP4A34P rat
UCSC browser
new pseudogene seq between 4A3 and 4A2 T
65% to 4A2 135837702-135845966 (+ strand)
MGIFELSHITTVFGISRLLQMVFWLGLLLLLFKAAQYYLRRQWIIKSFQQFPFPPSHWLFGNFLK
135838759 KDQDLQQIRLWVEKFPTACVRWFWGNHACVLIYDPD*MKVILG*S 135838887 aa 65-107
(exon 3 in a seq gap)
GYSLLLLNGKKWFQHRQMLTPAFHSDILKPYVGIMA
FSIFLLQDKWEELVGQDCPLEIYQDISLMTMETLINCAFSYQGSVQLE
NSRS*IKAVEDLTHLIHFRVRNGFH*SNIIYNLSSNGGSFHCACQIAHKHKG
DRVIRRRKVQLQSGVELEKIWKKWHLDLLDILLFAQ
EDGKSLSDEDLHAEVDTFMFEGHDTAARGISWIFYALPTHPEHQERCKEEVQSILGDGTSVTW
DHLDQMPYTTMCIKKALRLYPPGPAVSRELSTPVTFPDGCSSPKNSRISVV
IFGLHHNPRL*PNPE
VLDPFRFAPDVPQHTHAFLPFSAGAR
NCIRKLFAMNELKVAVTLTLL*LELLPDPTRVPFLVARTVLKSKIRIYLHLKKLK
CYP4A34P-de12b rat
UCSC browser
C-term aa 453-508 with one frameshift
frag f in fig. below
This may be the C-term of a full gene with the rest in a seq gap
135831318 RNCIGEHFAMNELKVAMALTLL 135831383
135831383 QFELLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135831484
human, mouse and rat 4ABXZ clusters
CYP4A35 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
81% to CYP4A11 human
CYP4A36 Canis familiaris (dog)
UCSC Genome browser June 13, 2005
This gene has a sequence gap that includes exons 5-9
70-75% to 4A11
16550556-16550750 exon 1
16553600-16553740 exon 2
16554459-16554503 exon 3
16554973-16555101 exon 4
16574267-16574332 exon 10
16574473-16574550 exon 11
16577168-16577332 exon 12
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKTAQLYQRRQWMLKAIQQFPSPPSHWFFGHKQE
FQTGLELQELKKRTEKYRCASPLWLWGSRVSLIVYDPDYMKMIPGRS
DPKSEGAYRFMAPWI
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMVDSVQVML
Sequence gap
GFLVLLSFYALHHNSNVWPNPE
VFDPSRFAPDASRHSHAFLPFSGGSR
NCIGQHFALKEMKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL*
CYP4A36-de10b11b12b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16531225-16531290 exon 10
16531430-16531507 exon 11
16533933-16534070 exon 12
GFLVLLSFYALHHNPNVWPNPE
VFDPSHFAPDASRHSHAVLPFSGGAR
XXXXXXXXXNELKVAVALTLLRFELAPDPFRIPVSTPKIVLMSKNGIHLHLRKLL*
CYP4A37 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
chr15 16582305-16601179
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQHRQWLLKAVQQFPSPPSHWFFGHKQE (0)
FQTGQELQVFQKWTEKYPCACPRWLWGSRVSLVVYDPDYMKMILGRS (1)
DPKAGGSYTFITPWI (1)
GYGLLLLHGEAWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDMNNLVFARVRNVFYQKDIFYGLTSEGRRNHKARQIAHQHT (1)
DRVIKLRKAQLQDEGELEKVRNKRHLDFLDILLFAK (0)
MENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK (1)
GFLVSLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGKHFAMNELKVAVALTLLRFELAPDPFKIPVPTPRIVLMSKNGIHLHLRKLL
CYP4A37 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 99% identical to boxer 4aa diffs
clone name: group 1
CYP4A38 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16616983-16617177 exon 1
16620038-16620178 exon 2
16627267-16627311 exon 3
16627767-16627895 exon 4
16629076-16629201 exon 5
16629573-16629725 exon 6
16630161-16630268 exon 7
16630360-16630551 exon 8
16630646-16630777 exon 9
16632476-16632541 exon 10
16632700-16632759 exon 11 frameshift extra "A" base
16634726-16634891 exon 12
MSVSLLSLTRPLDTVSGFLQVASLLGLALLLLKAAQFYWHRQWLLKAIQQFPSPPSHWFFGHRQE (0)
FQKGRELQELKKRTEKYPCASPRWLWGSRVSLVVYDPDYMRMILGRS (1)
DPKSDGSYRLMAPWI (1)
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARVRNVFYQKDIFYGLTSEGRRNHKACQLAHEHT (1)
DRVIKLRKAQLQDEGELEKIRNKRHLDFLDILLFAK (0)
MENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPR (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGQHFAMNELKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL*
CYP4A38 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 100% identical to boxer except for frameshift
clone name: group 2
CYP4A38 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 99% identical to boxer, 4 aa diffs
clone name: group 3
CYP4A39 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chr 15 16641912-16651675
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQRRQWLLKAVQQFPSPPSHWLFGHKRE (0)
LQKGDELQLLLKWIEDFPCAFSRWIWGTEAEIMIYDPDYMKLILGRS (1)
DPKPDGSYKLMAPWI (1)
GYGLLLLNGETWSQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLSQNSHLEIFDHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARMRNVFYQKDIFYGLTSEGRRNHKACQLAHQHT (1)
DRVIKLRKAQLQDKGELEKVRNKRHLDFLDILLFAK (0)
VENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPNVGRELSKPITFSDGRSLPK (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPGVSRHSHAFLPFSGGSR (2)
NCIGQHFAMNEMKVAVALTLLRFELAPDPFRIPVPTPKIVLMSKNGIHLHLRKLL*
CYP4A39-de12b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16655566-16655718 exon 12 (-) strand)
NCIGQQFAMNEMKVVTALCLLRFEFALDPLQLPVKMPQLILRSKNGIHLHL
CYP4A39-de9b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16657179-16657292 exon 9
XXXXXMTYLTMCIKESFRLYPPVPQVYRQLSKPVNFVDGRSLPX
CYP4A40 Bos taurus (cow)
See cattle page for details
MSVSALSPSRALGGVSGLLQVVSLLGLVLLLIKAAQLYLRRQWLLKALHHFPSPPSHWFCGHKWE
FQEEGELPHLLKRVEKYPRACVRWMWGTRALLLVYDPDYMKMVLGRS
DPKAQIIHRFVKPWI
GTGLLLLEGQTWFQHRRMLTPAFHYDILKPYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSQQGSVQTDR 369
SSQSYIQAIKDVSHLIISRLRNAFHQNDLIYRLTPEGHWNHRACQLAHQHT 895
DAVIKERKVRLQKEGELEKVRSRRHLDFLDILLFAR 1445
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQS 1690
LLADGASITW
DHLDQMPYTTMCIKEAMRLYPPVPVISRELSKPITFPDGHSLPA 1952
GILVSLSIYGLHHNPKVWPNPE
VFDPTRFAPGSTRHSHAFLPFSGGSR 3927
NCIGKQFAMNELKVAVALTLLRFELSPDSSRVPVPMPVIVLRSKNGIHLQLRKLSDPGGDK
CYP4A41 Bos taurus (cow)
See cattle page for details
MSVSVLSPTRALGGVSGLLQVVSLLGLVLLLLKAAQLYLRRQWLLKALHQFPSPPSHWFYGHKKE
FQKESELPPLLERVEKYPKACVRWLWGTKALVLVYDPDYMKVFLGRS
DPKPHRTYKYLAPWI
GTGLLLLEGQKWFQHRRMLTPAFRYDILKAYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSHQGSVQMDR
SSQSYIQAIRDLSHLIVSRLRNAFHQNDLIYRLTPEGRWNHRACQLTHQHT
DAVIKERKAHLQKEGELEKVRSRRHLDFLDILLLAR
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW
DHLDQMRYTTMCIKEAMRL
YPPVPFIGRELRKPITFPDGRSLPA
GILVSLSFYGLHHNPNVWPNPE
VFDPTRFSPGSTQHSYAFLPFSGGSR
NCIGKQFAMNELKVAVALTLLRFELSPDPSRVPVPTPIMVLRSKNGIHLQLRKLSDPGGDKDKL
CYP4A42P Bos taurus (cow)
See cattle page for details
KEKELEELLKRVEEFPYAYPCWMWG
DNVHLVVYDPDYMKVVLRRS
NPKSEDIYRFLAPWI
GLLLLEEQTWFQHRQMLTPAFHYDILKPYLGLMADSVQGML
DKWEELVSQDSHLEILGDISLMTLDTIMKCVFSH*GSIRNDR
XXXXXXXXXXXXXXXXXXXLRNVFYQNDLIYRLTPEGQWSY
XXXXXXXXX
TDAVIEERKTCLRKEGELEKVRSRRHLDFLDILLFSRV
NGSSLSDEDLRAEVDTFIFGGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW
CYP4A-se1[12] human
AL731892.5
76% to 4A11 C-term upstream of 4A11
old name = CYP4A26P
TCIGKKFAMNEL 135092
135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105
CYP4A-se2[1] human
GenEMBL NT_04852.13 - strand exon 1
7994933 MSVSVLNPNRLPDGVSGLLQGASLLSLLLLLLKAAQP*LHR 7994811
CYP4A-se3[12] human
AL731892.5
67% to 4A11 C-term
old name = CYP4A27P
168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322
CYP4A-se4[2] human
GenEMBL NT_04852.13 exon 2 - strand
8003576 XXXDQELKQFQKWVDF*IYPKRDFCDPVLTCCGGRKVHFLLYDPDKMEVILGRS 8003424
CYP4A rabbit
PIR PQ0048 (25 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
This fragment has 2 differences with 4A7
4B Subfamily
CYP4B1 human
GenEMBL NM_000779 J02871
Nhamburo,P.T., Gonzalez,F.J., McBride,O.W., Gelboin,H.V. and
Kimura,S.
Identification of a new P450 expressed in human lung: Complete cDNA
sequence, cDNA-directed expression and chromosome mapping
Biochemistry 28, 8060-8066 (1989)
CYP4B1 human
GenEMBL X16699
Yokotani,N., Sogawa,K., Matsubara,S., Gotoh,O., Kusunose,E.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA
library of human placenta. Gene structure and expression
Eur. J. Biochem. 187 (1), 23-29 (1990)
CYP4B1 Macaca mulatta (rhesus monkey)
NM_000779
95% to human 4B1
MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE (0)
IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG (1)
DPKAPDVYDFFLQWI (1)
GRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML (0)
DKWEEKAQEGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHR (2)
DSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLTPHGRRFLRACQVAHDHT (1)
DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR (0)
DEDDSKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQW (2)
DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA (1)
GSLISMHIYALHRNSAVWPDPE (0)
VFDPLRFSTENASKRHPFAFMPFSAGPR (2)
NCIGQQFAMSEMKVVTAMCLLHFEFSLDPSRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK
CYP4B1 rat
GenEMBL M29853
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL M29852
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL AF176914
Mastyugin,V., Aversa,E., Bonazzi,A., Vafaes,C., Mieyal,P. and
Schwartzman,M.L.
Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal
epithelium: involvement of a cytochrome P-4504B1 isoform
J. Pharmacol. Exp. Ther. 289 (3), 1611-1619 (1999)
Cyp4b1 mouse
GenEMBL D50834 (1871bp)
Imaoka,S., Hiroi,T., Tamura,Y., Yamazaki,H., Shimada,T., Komori,M.,
Degawa,M. and Funae,Y.
Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal
cytochrome P450, CYP4B1: Cloning and characterization of mouse
Cyp4b1.
Arch. Biochem. Biophys. 321, 255-262 (1995)
Cyp4b1 mouse
GenEMBL NT_039264.1 - strand
15793364 MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALE 15793185
15787670 IQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRG 15787524
15787339 DPKAAYVYDFFLQWIGK 15787289
15786110 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15785982
15782099 DKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSH 15781943
15781704 SDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHT 15781552
15781416 DHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGAR 15781309
15774536 DESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQW 15774345
15772616 DDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPA 15772485
15771566 GSLISLHIYALHRNSAVWPDPE 15771501
15771405 VFDPLRFSPENMTGRHPFAFMPFSAGP 15771325
15770907 RNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPGSGK 15770725
Cyp4b1-de2b4b mouse
GenEMBL NT_039264.1 - strand
v in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15690726 DLDKVGTWTEQFPYAHPLWLGQFVVFLNIYEPDYSKAVYSQA 15690601
15689190 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15689062
Cyp4b1-de10c11c12c mouse
GenEMBL NT_039264.1 - strand
u in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15728822 GSLISLHIYALHRNSAVWPDPE 15728757
15728661 VFDPLRFSPENMTGRHPFAFMPFSAGP 15728581
15728149 RNCIGQQFAMNKMKVV 15728102
15728100 TALCLLCFEISQDPLKIPIKVPQLILGSKNGIHLYLKPLGPGSGK 15727966
CYP4B1 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B2
73% to mouse Cyp4b1
CYP4B1 Sus scrofa (pig)
AK231936.1
CJ022616.1 BP435822.1 CF179484.1 AW480803.1 CJ026219.1
BP440482.1
80% to human 4B1, 81% to cow 4B2
MVPALLSLSLSHLSLWALGLILALGVLKLTSLLLRRQMLARAMDK
FPGPPTHWIFGHALEIQQTGSLDKMVSWAHQFPHAHPLWLGPFLGFLNIYEPEYAKAVYS
RGDPKASDLYDFFLQWIGKGLLVLHGPKWFQHRKLLTPGFHHDVLKPYVAVMANSARVML
DKWEEKAREDKSFDIYHDVGHMALELLMKC
TFGKGTSGLNYSDNAYHLAVRDLTLLMQQRLSSFQYHNDFIYWLTPHGRRFLRACRVAHD
HTDQVIRERKAALQDKEEQERIQSRRHLDFLDILLGAQDEDRVKLPDADLRAEVDTFMFG
GHDTTTRGISWFLYCMSLNPEHQHRCRDEIREILGDRDSIQGEDLGKMTYLTMCIRESFRLYPP
GPQVYRQLSEPVSFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRH
PFAFLPFSAGPRNCIGQQFAMNEMKVVAALSLLRFEFAPDPSRPPIPMPQLTLCSKTGIH
LRLTSLGQGSGK*
CYP4B1 Bos taurus cattle
GenEMBL AW347853
Differs from 4B2 shown below
This seq is 100% match to pig 4B1 (possible contamination?)
Efforts to extend this sequence in genomic DNA have failed
3 DGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRHPFAFLPFSAGPRNC 179
CYP4B2 Bos taurus (cow)
See cattle page for details
94% to goat 4B2 only 82% to human 4B1
note: there was some evidence for two CYP4B genes in cow,
but only one can be found in the genomic data so far.
This may be the CYP4B1 ortholog and 4B1 may be a pig sequence.
MVPVLLSLSLSHLSLWAFALVSVLVFLKLTRLLLRRQMLARAMDRFSGPPTHWLFGHALE
IQQTGSLDKVVSWTHEFPYAHQLWVGQFLGFLNIYDPDYAKAVYSR
GDPKAPDFYDFFLQWI
GKGLLVLQGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML
DKWEKKAREQKSFDIYSDVGHMALDSLMKCTFGKGTSGLNDR
DNNYYLSVKELTLLMQQRIDSFQYHNDFIYFLTPHGRRFLRACQVAHDHT
DQVIRERKAALQDEKERERIQSKRHLDFLDILLGAW
DEEGIKLSDEDLRAEVDTFMFEGHDTTTSAISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKW
DDLAEMTYLTMCIKESFRL
YPPVPQVYRQLSQPVNFVDGRSLPE
GSLISLHIYALHRNSTVWPDPE
VFDPLRFSPENVAGRHSFAFIPFSAGPR
NCIGQQFAMAEVKVVTALCLLRFEFSPDPSRLPIKMPQLVLRSKNGIHLHLKPLGPGSEK*
CYP4B2 Capra hircus (goat)
No accession number
Garold Yost
Submitted to nomenclature committee August 2002
82% to human 4B1, 94% to bovine 4B2 (partial)
CYP4B2 Bos taurus cattle
GenEMBL BF602740
94% to goat 4B2 only 82% to human 4B1
3 AISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKWDDLAEMTYLTMCIKESFRLYPPVPQ 182
183 VYRQLSQPVNFVDGRSLPEGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENVARRHSFA 362
363 FIPFSAGPRNCIGQQFAMAEVKVVTALCLLRFEFAPDP 476
CYP4B3 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B1
69% to mouse Cyp4b1
4C Subfamily
CYP4C1 Blaberus discoidalis (cockroach)
GenEMBL M63798 Swiss P29981 (511 amino acids)
Bradfield,J.Y., Lee,Y.-H. and Keeley,L.L.
Cytochrome P450 family 4 in a cockroach: Molecular cloning and
regulation by hypertrehalosemic hormone
Proc. Natl. Acad. Sci. U.S.A. 88, 4558-4562 (1991)
CYP4C2 Anopheles albimanus (mosquito)
GenEMBL L38678 (379bp) PIR PC2257 (126 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4c3 Drosophila melanogaster
GenEMBL U34323(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4c3 Drosophila melanogaster
AC014779 73845-80196 also AC008219
Cyp4c3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4C4 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071073
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C4
Unpublished
CYP4C5 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071074
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C5
Unpublished
CYP4C6 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071075
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C6
Unpublished
CYP4C7 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071072
Andersen,J.F. and Feyereisen,R.
CYP4C7, a P450 from cockroach corpora allata
Unpublished
CYP4C8 Mastotermes darwiniensis (Australian termite)
GenEMBL U77126(432bp)
Falckh,P.H.J., Balcombe,W.M., Haritos,V.S. and Ahokas,J.T.
Isolation, identification and sequence of a cytochrome P450 in an
Australian termite, Mastotermes darwiniensis.
unpublished (1996)
note: 92 amino acid C-terminal fragment
CYP4C9 Coptotermes acinaciformis (termite)
GenEMBL AF046008
Patrick Falckh
C4-8_9-A
CYP4C10 Coptotermes acinaciformis (termite)
GenEMBL AF046009
Patrick Falckh
C4-8_9-I
CYP4C11 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067631
Quoc Wu
M4-150.4
CYP4C12 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067632
Quoc Wu
M4-100-8
CYP4C13 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067633
Quoc Wu
M4-240-2
CYP4C14 Coptotermes acinaciformis (termite)
GenEMBL AF067634
Quoc Wu
4F-22_24
CYP4C15X Orconectes limosus (crayfish)
GenEMBL AF091117
Chantal Dauphin-Villemant
submitted to nomenclature committee
this is a tentative assignment, this sequence may require its own
subfamily
50% identical to 4C1 over full length, 58% identical over C-terminal
renamed CYP4V11
CYP4C16X Penaeus setiferus (shrimp)
GenEMBL AF072854
Mark Snyder
submitted to nomenclature committee
renamed CYP4V12
CYP4C17X Haliotis rufescens (red abalone)
GenEMBL AF072853
Mark Snyder
submitted to nomenclature committee
renamed CYP4V13
CYP4C18X Homarus americanus (lobster)
GenEMBL AF072852
Mark Snyder
submitted to nomenclature committee
renamed CYP4V14
CYP4C19 Lytechinus anamesis (sea urchin)
GenEMBL AF072850
Mark Snyder
submitted to nomenclature committee
first sequence from sea urchin
CYP4C20 Lytechinus anamesis (sea urchin)
GenEMBL AF072851
Mark Snyder
submitted to nomenclature committee
second sequence from sea urchin
CYP4C21 Blattella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee Dec. 30, 1998
CYP4C22v1 Culex pipiens pallens (mosquito)
GenEMBL AF157093
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 150 amino acids
clone name NYDR2 81% identical to 4C2
this sequence has one frameshift
EVDTFMFEGHDTTSAAISWILLLLGAEPAIQDRIVEEIDEIMGG
DRDRFPTMKELNDMKYLECCIKEGLRLYPSVPLIARKLVEDCVVQDYTIPAGTTAMIV
VYQLHRDPAVFPNPDKFNPDHFAPENCRGRHPYAYIPFMAGPRNCIGH
CYP4C22v2 Culex pipiens
AF208659
Changliang Zhu
Clone NYDS6 PCR fragment 97% identical to 4C22v1
Submitted to nomenclature committee 9/30/99
TSAAISWILLLLGAEPAIQDRIVEEIDQIMGGDRDRFPTMKELN
DMKYLECCIKEGLRLYPSVPLIARQLVEDCVVQDYSIPAGTTAMIVVYQPHRDPAVFP
NPDKFNPDHFAPENCRGRHPYAYI
CYP4C23 Culex pipiens pallens (mosquito)
GenEMBL AF157090
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 167 amino acids
clone name NYDS1 84% identical to AF117650 at C-terminal 44 amino acids
this sequence has numerous frameshifts and insertions/deletions it may
be a pseudogene
MFEGHDTTAAGIILTIMLPANEQDAQRRVYEDLSKARRLKPEHE
AFTIADYTNLKYLDRFVKEALRLYPPVSFISRSLTGRLDVGRYSKLPVNQILVHIELL
NRSHHHLAARNYRQHSHLRSAPYPEQFPDPERFDPDRFLPEVSAKRNPYAYVPFCAGP
RNCIGH
CYP4C24 Orconectes limosus (crayfish)
no accession number
C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bšcking
submited to nomenclature committee 6/15/99
CYP4C25 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Q
CYPb1x3 on chromosome 1
91% identical to 4C2
CYP4C25 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x3
CYP4C25 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 5
98% identical to CYP4C25 Anopheles gambiae probable ortholog
only 2 amino acid differences
CYP4C26 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450S
CYPb1x1 on chromosome 1
73% identical to 4C2
CYP4C26 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x1
CYP4C27 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450I
CYPo3r3 on chromosome 3
58% identical to 4C6
CYP4C27 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r3
CYP4C28 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450R
CYPs3l1 on chromosome 3
61% identical to 4C2
CYP4C28 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3l1
CYP4C29X Cherax quadricarinatus (crayfish)
No accession number
Moshe Tom
Submitted to nomenclature committee May 4, 2000
Clusters with the other crayfish sequence 4C24 on trees
Reanmed CYP4V15
CYP4C30 Coscinasterias muricata Australian sea star (11 armed starfish)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
63% to 4C19 partial seq. from I-helix to heme
CYP4C31 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.5 203 aa
65% to 4C24 crayfish 65% to 4C16 shrimp 69% to 4C18 lobster
68% to 4C17 abalone 82% to 4C33
CYP4C32 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.6 149 aa
95% to 4C34
CYP4C33 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.14 200 aa
62% to 4C24 crayfish 61% to 4C16 shrimp 66% to 4C18 lobster
66% to 4C17 abalone 82% to 4C31
CYP4C34 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.16 206 aa
61% to 4C24 crayfish 63% to 4C16 shrimp 64% to 4C18 lobster
65% to 4C17 abalone 95% to 4C32
CYP4C35 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r1
CYP4C36 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r2
CYP4C37 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x2
CYP4C38 Aedes aegypti (yellow fever mosquito)
CYP4C38 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.4
CYP4C38 Culex pipiens
CYP4C39X Carcinus maenas (shore crab)
GenEMBL AY328467
Kim Rewitz
submitted to nomenclature committee 6/18/2003
59.5% to 4C15
renamed CYP4V16
CYP4C40 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 3 same as contig2
88% to 4C36
probable ortholog of 4C35
note 4C35 is only 84% to 4C36 and less to all other gambiae CYP4Cs
CYP4C41 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 9
93% to 4C27
probable ortholog of 4C27
CYP4C42 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4C
83% to 4C3 (106 aa)
CYP4C43v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #2v1
72% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v2
CYP4C43v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #2v2
71% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v1
CYP4C44v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #3v1
88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v2
CYP4C44v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #3v2
88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v1
CYP4C45v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #4v1
66% to 4C13 I-helix to heme, 99.7% identical to CYP4C45v2
CYP4C45v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #4v2
66% to 4C12 I-helix to heme, 99.7% identical to CYP4C45v1
CYP4C46 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #5
86% to 4C14 I-helix to heme
CYP4C47 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #6
61% to 4C13 I-helix to heme
note name may change when full seq is known
CYP4C48 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #7
90% to 4C9 I-helix to heme
CYP4C49 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 58_23_ext
63% identical to CYP4C17 Haliotis rufescens (red abalone) partial seq.
CYP4C50 Aedes aegypti (yellow fever mosquito)
CYP4C50v1 Culex pipiens
CYP4C50v2 Culex pipiens
CYP4C51 Aedes aegypti (yellow fever mosquito)
CYP4C51v1 Culex pipiens
CYP4C51v2 Culex pipiens
CYP4C52 Aedes aegypti (yellow fever mosquito)
CYP4C52v1 Culex pipiens
CYP4C52v2 Culex pipiens
CYP4C53 Daphnia magna (water flea)
GenEMBL AB257772
Yoshinori Ikenaka
Submitted to nomenclature committee 8/28/06
CYP family-2, full length sequence
70% to CYP4C31, amino acids 88 to end 55% to 4V2 human
The CYP4C subfamily in invertebrates may be the orthologous
group to the chordate CYP4V sequences
CYP4C53 Daphnia pulex (water flea)
confidential
CYP4C54X Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia,
49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
Clone name Lv03
Renamed CYP4V17
CYP4C55 Daphnia pulex (water flea)
confidential
CYP4C56 Daphnia pulex (water flea)
confidential
CYP4C57 Daphnia pulex (water flea)
confidential
CYP4C58 Daphnia pulex (water flea)
confidential
CYP4C59 Daphnia pulex (water flea)
confidential
CYP4C60 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4C61 Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
No accession number
Zhifan Yang
Submitted to nomenclature committee 5/23/08
Clone CYP4-2
55% to CYP4C62, 47% to CYP4C27
CYP4C62 Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
No accession number
Zhifan Yang
Submitted to nomenclature committee 5/23/08
Clone CYP4-6
55% to CYP4C1
4D Subfamily
Cyp4d1 Drosophila melanogaster
GenEMBL X67645 (1675bp) Swiss P33269 (511 amino acids)
PIR S25707 (511 amino acids)
Gandhi,R., Varak,E. and Goldberg,M.L.
Molecular analysis of a cytochrome P450 gene of family 4 on the
Drosophia X chromosome.
DNA Cell Biol. 11, 397-404 (1992)
note: X67645 has a probable frameshifts at the C-terminal
see Z98269 and AF016992 to AF017004 for correct end
Cyp4d1 Drosophila melanogaster
GenEMBL AC017770 49988-51720
Alternative splice AC017770 48817-51720
Cyp4d1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4d1_v1b Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
(alt splice, exon 1)
Cyp4d2 Drosophila melanogaster
GenEMBL Z23005 (1481bp) X75955 (1883bp) PIR S41192 (496 amino acids)
Frolov,M.V. and Alatortsev,V.E.
Cluster of cytochrome P450 genes on the X-chromosome of
Drosophila melanogaster
DNA Cell Biol. 13, 663-668 (1994)
probable frameshift at C-terminal
see Al009194 and AF017006 to AF017019 for correct end
Cyp4d2 Drosophila melanogaster
GenEMBL AC017770 comp(32267-34028)
Cyp4d2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D3v1 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4d3v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
68% to 4d1 D. pseudoobscura
3 aa diffs to 4D3v1
CYP4D4v1 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4d4v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
57% to 4d14 D melano.,
100% to 4D4v2 (PCR fragment), 4 aa diffs to 4D4v1
CYP4D5 Anopheles albimanus (mosquito)
GenEMBL L38679 (382bp) PIR PC2270 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D6 Anopheles albimanus (mosquito)
GenEMBL L38680 (446bp) PIR PC2271 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D7 Anopheles albimanus (mosquito)
GenEMBL L38681 (447bp) PIR PC2272 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4d8 Drosophila melanogaster
GenEMBL U34329(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Dro-G453 (formerly called 4N3)
Cyp4d8 Drosophila melanogaster
GenEMBL AC017388 comp(37292-39859)
also AC010557 AC010112 AC010113
Cyp4d8 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D9 Musca domestica
Rene Feyereisen
no accession number
6-full
submitted to nomenclature committee
CYP4D10 Drosophila mettleri
GenEMBL U91634
Jim Fogleman
full length sequence 288mt
submitted to nomenclature committee (one of 109 sequences)
CYP4D11 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD60 PCR of C-terminal
CYP4D12 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD5 PCR of C-terminal
CYP4D13 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD84 PCR of C-terminal
Cyp4d14 Drosophila melanogaster
GenEMBL AL009194 comp(10685-12421)
also submitted by Michael Goldberg
55% identical to Cyp4d2
Cyp4d14 Drosophila melanogaster
GenEMBL AC017770 35699-37438
Cyp4d14 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450E
77% identical to 4D6
CYP4D15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r3
CYP4D16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450F
84% identical to 4D6
CYP4D16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r5
CYP4D17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450H
79% identical to 4D5
CYP4D17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r4
CYP4D18v1 Culex pipiens
GenEMBL AF190775
Changliang Zhu
Clone NYDS2 PCR fragment 95% identical to 4D18v2, 66% to 4D6
Submitted to nomenclature committee 9/30/99
TTSAMSFILGILAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPMFGRKMLENHDIGKFWQRNAVLLVKLNAPKPLPYGTIF
PAGSNVIVMPYIMGRDPEYFDDPLEFRPERFAVETSAEKSNPYRYV
CYP4D18v2 Culex pipiens
AF191728
Changliang Zhu
Clone NYDR16 PCR fragment 95% identical to 4D18v1
Submitted to nomenclature committee 9/30/99
TTSAMSFLLGVLAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPIFGRKMLENHDIGKFWHRNAVLLVKLNAPKPLPDGTIF
PAGSNVIIMPYIMGRDPDYFDDPLEFRPERFAVETSAEKSNPYRYV
CYP4D19 Culex pipiens
CPIJ009477
CYP4D19v1 Culex pipiens
AF190786
Changliang Zhu
Clone NYDR11 PCR fragment 3 diffs with 4D19v2
Submitted to nomenclature committee 9/30/99
TSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLNE
LTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYDN
PLEFIPERFEGEKSVEKFNPYKYV
CYP4D19v2 Culex pipiens
AF190789
Changliang Zhu
Clone NYDR14 PCR fragment 3 diffs with 4D19v1
Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPAIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIITGIYYMGRDANYYD
NPLEFIPERFEGEKSVGKFNPYKYV
CYP4D19v3 Culex pipiens
GenEMBL AF190777
Changliang Zhu
Clone NYDS4 PCR fragment 95% identical to 4D19v2, 54% to 4D5
Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSLPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYD
NPPELIPERFEGEKSVEKFNPYKYV
Cyp4d20 Drosophila melanogaster
GenEMBL AC019509 comp(19731-21636)
Cyp4d20 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4d21 Drosophila melanogaster
GenEMBL AC020004 55466-57280
CYP4D22 Anopheles gambiae (malaria mosquito)
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450O
50% identical to 4H5, 4H7
note the 4H subfamily might really be considered two differernt
subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.
4H20 falls between these. Revised seq now groups with CYP4Ds
formerly CYP4H20
CYP4D22 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r6
CYP4D23 Aedes aegypti (yellow fever mosquito)
CYP4D23v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.8
CYP4D23v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.3
CYP4D23v3 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.1
CYP4D24 Aedes aegypti (yellow fever mosquito)
CYP4D24 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.6
CYP4D25 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 5
94% to 4D22
probable ortholog of 4D22
CYP4D26 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 8
85% to 4D15, 78% to 4D27
CYP4D27 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 10
86% to 4D17 78% to contig 10 possible ortholog of 4D17
79% to 4D16 and 80% to 4D15
CYP4D28 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D1
55% to 4D2 (276 aa)
CYP4D29v1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D2
56% to 4D2 (278 aa)
CYP4D29v2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0103K16
57% identical to Drosoph. CYP4d2 only 5 aa diffs to 4D29v1 98%
CYP4D30 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D3
82% to 4D3 (150 aa)
CYP4D31 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D4
72% to 4D4 (149 aa)
CYP4D32 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D5
72% to 4D2 (149 aa)
CYP4D33 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D6
63% to 4D2 81% to 4D29 (149 aa)
CYP4D34 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D7
61% to 4D20 81% to 4D33 (150 aa)
CYP4D35 Musca domestica (house fly)
No accession number
Nannan Liu
50% identical to 4d8, 79% to 4D36
clone #12
submitted to nomenclature committee 4/10/06
CYP4D36 Musca domestica (house fly)
No accession number
Nannan Liu
61% identical to 4d4 fragment, 79% to 4D35
clone #12prime
Missing C-term after EXXR motif
submitted to nomenclature committee 4/10/06
CYP4D37 Aedes aegypti (yellow fever mosquito)
CYP4D38 Aedes aegypti (yellow fever mosquito)
CYP4D39 Aedes aegypti (yellow fever mosquito)
CYP4D40 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 2
84% to 03, 67% to 4D24 Aedes
96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
CYP40 and CYP41 may be paralogs of CYP4D18
CYP4D40 Culex pipiens
CYP4D41 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 3
60% to CYP4D16 Anoph. 66% to 4D24 Aedes
96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
CYP40 and CYP41 may be paralogs of CYP4D18
CYP4D41 Culex pipiens
CYP4D42 Culex pipiens pallens
CB074945.1
NJS1618(2) 488bp, NJ008 in Genbank entry
58% to CYP4H12v5, 77% to 4D22, 84% to 4D23
GRGNSIEVDTFMFEGHDTTTIAITFTLMLLAKHPDIQEKVYQEVTEIIGKDLNAPTTYRN
LQDMKYLELVIKESLRLYPPVPIIGRKFTEKTEIDGKVVPEDSNFNVGIILMHRDPTQFE
DPERFDPERFSPERTTELSSPYAYIPFSAGPRNCIGQNH
CYP4D42v1 Culex pipiens
CYP4D42v2 Culex pipiens
CYP4D43 Culex pipiens pallens
CB074951.1
NJS1618(4) 488bp, NJ008 in Genbank entry
57% to CYP4D42 70% to 4D16
GRGNSIEVDTFMFEGHDTTTSAISFLMYRLARHPEVQRKVYEEIVAVIGADRDRPVTLAM
LNELHYLELVVKETLRLYPSVPFYGRKILENCEIEGRTFPAGANVIIMPFFMGRDSEYFE
DPQKFRPERFAVGTSAEKTNPYRYIPFSAGPRNCIGQNH
CYP4D43 Culex pipiens
CYP4D44 Culex pipiens
CYP4D45P Culex pipiens
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4I1.3
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.6
4E Subfamily
Cyp4e1 Drosophila melanogaster
GenEMBL AC020402 44580-46698
CYP4E1 HAS INSERT AT C-TERM VSKDGYISTTLGLQPAEKKSRDAHNHK
Cyp4e2 Drosophila melanogaster
no accession number
Amichot, M., Brun, A., Cuany, A., Helvig, C., Salaun, J. P., Durst, F.
and Berge, J. B.
Expression study of CYP genes in drosophila strains
resistant or sensitive to insecticides. In: Cytochrome P450
Lechner M.C. ed. John Libbey Eurotext, Paris.pp. 689-692 (1994)
(PCR fragment) 144 amino acid region
Cyp4e1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e2 Drosophila melanogaster
GenEMBL X86076(1408bp)
Amichot,M., Brun,A., Cuany,A., LeMouel,T. and Berge,J.
Cloning and expression study of CYP4E2 a novel P450 gene in
drosophila.
unpublished (1995)
Cyp4e2 Drosophila melanogaster
GenEMBL U56957(1458bp) U34332(373bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4e2 Drosophila melanogaster
GenEMBL AC020402 41848-44099
Cyp4e2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e3 Drosophila melanogaster
GenEMBL U34330(370bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
DroG4-2
Cyp4e3 Drosophila melanogaster
GenEMBL AC020324 73117-75125
Cyp4e3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e4x Drosophila melanogaster
GenEMBL U34331(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
formerly called 4N4
note: this sequence is pretty far out in the 4E subfamily
it has been reassigned as Cyp4ae1
CYP4E5 Drosophila mettleri
GenEMBL U78486
Phil Danielson
Mt1
CYP4E6 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD21 PCR of C-terminal
CYP4E7 Musca domestica (house fly)
no accession number (530 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee
CYP4E8 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4E
70% to 4E2 (150 aa)
4F Subfamily
CYP4F1 rat
GenEMBL S53039 M94548 (1977bp) Swiss P33274 (524 amino acids)
PIR S29723 (524 amino acids)
Chen,L. and Hardwick,J.P.
Identification of a new P450 subfamily, CYP4F1, expressed
in rat hepatic tumors.
Arch. Biochem. Biophys. 300, 18-23 (1993)
Note: rat 4F1 has an alternatively spliced 3 prime untranslated exon
CYP4F2 human
GenEMBL U02388 (2368bp)
Chen,L. and Hardwick,J.P.
The human liver CYP4F2 cDNA sequence and expression in
baculovirus-infected cells.
unpublished (1993)
CYP4F2 human
GenEMBL D26480 (2227bp)
Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
Kusunose,M.
Cloning and expression of a novel form of leukotriene B4
omega-hydroxylase from human liver
FEBS Lett. 348, 70-74 (1994)
CYP4F2-de12b human
NT_011281.4|Hs19_11438
chromosome 19 detritus exon 12 75% TO 4F11
Old name = CYP4F36P
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448
CYP4F3 human
GenEMBL D12620 (2073bp) D12621 (1185bp) S63604 (2073bp)
Swiss Q08477 (520 amino acids)
Kikuta,Y., Kusunose,E., Endo,K., Yamamoto,S., Sogawa,K,
Fujii-Kuriyama,Y. and Kusunose,M.
A novel form of cytochrome P-450 family 4 in human
polymorphonuclear leukocytes. cDNA cloning and expression of
leukotriene B4 omega-hydroxylase.
J. Biol. Chem. 268, 9376-9380 (1993)
Note: three overlapping clones F-22, A-4 and M-6 are identical.
Clone S-8 is different at 4 nucleotides and one amino acid.
CYP4F3 human
GenEMBL AD000685 12 exons from 26660-44629
CYP4F3v2 human
GenEMBL AF054821
Kanga Morgan
alternative splice variant of 4F3 with a cryptic exon at amino acids
67-114 this exon resembles the region in 4F2.
CYP4F3v2 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F2#2
88% to 4F3v1, 94% to AF054821
one exon may be alternate splice this is the case in humans
CYP4F4 rat
GenEMBL U39206
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F5 rat
GenEMBL U39207
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F6 rat
GenEMBL U39208
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F7 Dicentrarchus labrax (European sea bass)
GenEMBL AF045925
Sabourault C, Amichot M, Pauron D, Berge JB, Lafaurie M, Girard JP
Cloning of CYP4F7, a kidney-specific P450 in the sea bass Dicentrarchus
labrax.
Biochem Biophys Res Commun 258, 155-61 1999
62% identical to human 4F3
authors name CYP4Dl2
Query: 1 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKES 60
GHDTTAS + W LY+LA+H +YQE+CRQEV EL++ R+ EIEW+DL+ LPF TMCI+ES
Sbjct: 1 GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES 180
Query: 61 LRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPK 120
LRLH PV AV+R TQD+ LP +PKG ICL+S++GTHHNP VW +P + P RFDP
Sbjct: 181 LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT 360
Query: 121 NIKERSPLAFIPFSAGPRNCIGQAFAMAE 149
N + + AFIPFS+GPRNCIGQ FA+AE
Sbjct: 361 NKEGLAAHAFIPFSSGPRNCIGQKFALAE 447
Sequence of reported protein may have 2 frameshifts at the end
See alignment below to human 4F3 as query
Possible corrected sequence
GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES
LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT
NKEGLAAHAFIPFSSGPRNCIGQKFALAELRVVVALTLLRFRLTLGVNPEVGPSSGEVRR
LPQLVLRAEGGMWLQVEPL
Score = 85 (29.9 bits), Expect = 6.3e-62, Sum P(2) = 6.3e-62
Identities = 23/59 (38%), Positives = 31/59 (52%), Frame = +2
Query: 132 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVL--------PDHTEPRRKPELVLRAEG 182
PF P + ++ ++VV+ LTLL FR+ P E RR P+LVLRAEG
Sbjct: 395 PFPQAPGTALVRSSPWQRLRVVVALTLLRFRLTLGVNPEVGPSSGEVRRLPQLVLRAEG 571
Score = 54 (19.0 bits), Expect = 1.2e-58, Sum P(2) = 1.2e-58
Identities = 10/18 (55%), Positives = 12/18 (66%), Frame = +3
Query: 174 PELVLRAEGGLWLRVEPL 191
P L GG+WL+VEPL
Sbjct: 546 PSLSCVQRGGMWLQVEPL 599
CYP4F8 human
GenEMBL AD000685 13 exons from 862-14599
GenEMBL AF133298
Bylund, J., Finnstršm, N. and Oliw, E. H. (1999) Gene Expression of a
Novel Cytochrome P450 of the CYP4F subfamily in Human Seminal Vesicles.
Biochem. Biophys. Res. Commun. 261, 169-174.
submitted to nomenclature committee 10/30/98
81.2% identity with CYP4F2 and 76.7% with CYP4F3.
EST AI401776, AI349730
CYP4F9P HUMAN
GenEMBL AC004609 complement(13903-33104 region)
pseudogene N-terminal not on this cosmid, may be on adjacent cosmid
missing 71 amino acids at N-terminal
69% identical to 4F3 67% identical to 4F8
EGMRVLTQLVATYPQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKD
EAFYKFLKPWLGDGLLVNASDKWSCHRQMLMPAFHFNMLKPYMKFFTDSV
NIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQKCVFSFDSHCQEKPSQYIATI
LELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVHDFTEAIIQEQRH
TLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXXXXXX
GHNTTASGLSWVLYYLARHPEYQEHCWQEVQKLLKDHEPKEIEX
DDLAQLPFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLF
SNFETHHNPTVWLDPEVYDPFRFDPENSKERSPLAFIPFSAGSX
NCIGQAFAMAEMKVVLALTLLCFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS
CYP4F10P human
GenEMBL AD000685 exons 3-6 (cosmid ends in middle of exon 6)
49350 to end of cosmid. Cannot recognize exons 1 and 2 after 4F3 gene
ends at 44623 and before exon 3 starts at 49350. May be a pseudogene
(No ESTs)
SATIAPKDKVFYSFLKPWLG
DGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNIMH
AKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQE
KPSEYIASVLELSSLVAKRNQQ
CYP4F11 human
GenEMBL AC005336 cosmid F20129 end of cosmid
ESTs T56269 and T56204 opposite ends of clone yb89b03
ESTs T69576 and T69645 opposite ends of clone yc44c03
EST AA991369 and EST W23003
N-terminal up though C helix and C-terminal from I helix to end is
Present middle region is not present. The rest of this gene should be
on cosmid R28342 this is not in the database yet. About 22 amino acids
missing at N-terminal
N-terminal is on AC011517 rest is on AC020950
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQC
FPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLI
LCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRML
TPAFHFNLKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDS
LQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQR
FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD
EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEV
QELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG
RVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGP
RNCIGQAFAMAEMKVVLALTLLHFRILPTHIEPRRKPELILRAEGGLWLRVEPLGANSQ
CYP4F11 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F11_2-E5
91% to 4F11 human 80% to 4F12 human
CYP4F12 human
GenEMBL AC004523 missing N-terminal
UNIGENE entry Hs.110130 (12 ESTs)
UNIGENE Hs.168862 R08175 and R08229 (opposite end)
Complete cDNA sequence submitted by Johan Bylund June 16, 2000
mRNA for cytochrome P450, complete cds. AB035130
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNN
CRRLQCFPQPPKRNWFWGHLGL
ITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLC
HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
EGGLWLRVEPLNVGLQ
CYP4F12 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F12_2-G6
91% to 4F12 human 82% to 4F11 human
Cyp4f13 mouse
GenEMBL ESTs AI304244 ui64h08.y1, AA277579 va77c04.r1
AA238458 my34d11.r1, AA277631 va81d08.r1
AI265156 uj03h07.y1, AI120320 ub69c04.r1
AI327511 mb31b06.y1, AA245188 mx09e08.r1
AA799238 vx69h12.r1, AA797204 vw22d08.r1
AI196488 ui64h08.x1, AI196852 ui67e09.x1
AA511038 vh55g04.r1,AI323999 mb31b06.x1
W64560 md70f05.r1, AI121221 ud70e01.x1
Unigene Mm.22045
89% identical to rat CYP4F6 probable ortholog
CONSENSUS
MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWF
WGHLALMKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKP
WLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLD
MFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQP
FLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLD
FIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILYNXXXXXXXXXXXXX
EVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAI
PKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFA
MSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ*
Cyp4f13 mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand.
seq gap at exon 7,8
Mm.22045 15 ESTs follow AI323999 BF533850 BC003954 AF233643
9512124 MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLAL 9511927
9506326 MKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQA 9506186
9497701 SAAVAPKEMTLYGFLKPWL 9497645
9497556 GDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMH 9497428
9495574 AKWQCLASKGTSRLDMFEHISLMTLDSLQKCIFSVDSNCQE 9495452
9495033 SDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFT
DAVIKERRSTLNTQGVEFLKAKAKTKTLDFI 9494788
DVLLMAE
DEHGKGLSNEDIRAEADTFMFGG
HDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEW
9490318 DDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPK 9490187
9490098 GNICVISIFGVHHNPSVWPDPE 9490033
9489902 VYNPFRFDPENPQKRSPLAFIPFSAGT 9489822
9489452 RNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ* 9489273
Cyp4f14 mouse
GenEMBL ESTs
AI098768 ue38c01.y1
AI047403 ud65h03.y1
AI099192 ue40b11.y1
AA237519 mx10h12.r1
AA793220 vl85g08.r1
AA869706 vq44d03.r1
AI118365 ue40b11.x1 chimeric clone contains a-L-Fucosidase
AA880205 vx39b01.r1
consensus N-terminal to 370
MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWL
MGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALK
DVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQR
VISDGSAPLDMFEHVSLMTLDSLQKCVVFSFDSNCQEKSSEYIAAILELSALVAK
KDQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD
FIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQE
VQELLRGREPEE
gap of 69 amino acids
Cyp4f14 Cterminal 439-524
AI046446 ud65h03.x1 C-term
AA274495 vb07d01.r1 C-term
AI121221 ud70e01.x1 C-term
consensus
VYDXFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVE
PLSAGAH*
UNIGENE entry Mm.10976 (C-terminal part only)
92% identical to rat CYP4F1 probable ortholog
Cyp4f14 mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand
80% to 4f15
Mm.10976 C-term only. AF233644 AK018676 AC073720 91k-108k
9480783 MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGM 9480586
9478580 VTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNA 9478440
9475637 SAAVALKDVIFYSILKPWL 9475581
9475492 GDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9475364
9475203 AKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQE 9475081
9473316 KSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSK 9473047
9471961 DEDGKELSDEDIRAEADTFMFEG 9471893
9471699 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEW 9471571
9470493 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPK 9470362
9470279 GIICLISIFGIHHNPSVWPDPE 9470214
9470056 VYDPFRFDPENIKDSSPLAFIPFSAGP 9469976
9469605 RNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLSAGAH* 9469426
Cyp4f15 mouse
GenEMBL ESTs
AI315840 uj47c01.y1
AI046615 ud70e01.y1
AI048594 ud61g02.y1 this clone skips over exons
MPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWF
LGHLGMITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALK
EVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQH
LALGGSARLDVFENISLMTLD
AI048594 ud61g02.y1 407-480
AI121221 ud70e01.x1 C-term this fragment also is an exact match to 4f13 and 4f14
There may have been gene conversion at the C-terminal of these three genes.
LLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPR
NCIGQTFAMNEMXVXXXXXXXXXXXXPDDKEPRRKPELILRAEGGLWLRVEPLSTQ
No UNIGENE entry for these ESTs
92% identical to rat CYP4F4 probable ortholog
Cyp4f15 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
Mm.26539 AF233645 1EST AI121221 AK018904
MGFF
9250760 RMPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGM 9250960
9255347 ITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNA 9255487
9257115 SASVALKEVVFYSFLKPWL 9257171
9257260 GDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9257388
9259977 AKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQE 9260099
9262477 NPSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSK 9262746
9264634 DEDGKELSDEDIRAEADTFMFEG 9264702
9264910 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIEW 9265038
9266608 DDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPK 9266739
9266828 GVICIINIFATHHNPTVWPDPE 9266893
9267035 VYDPFRFDPENIKDRSPLAFIPFSAGP 9267115
9267490 RNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ* 9267663
Cyp4f16 mouse
GenEMBL ESTs AA059667 mj77a08.r1
AA863889 vx15d11.r1, AA673923 vo83a09.r1
AA798644 vw34b12.r1, AA896484 vx63d12.r1
MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWF
SGHLGMIQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWL
GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMF
EHISLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSXXXXXXXXXXXXXXX
Cyp4f fragment a 93% identical to 4F5 88% to 4F6, 86% to 4F1 83% to 4F4
This fragment belongs to Cyp4f16
AA671839 vl02c09.r1
AA755081 vu02b08.r1
LYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVL
LLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQRVQE
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDXXXXXXX
Cyp4f fragment c 91% identical to 4F6, 86% to 4F1 and 4F5, 85% to 4F4
This fragment is part of Cyp4f16
AA688499 vq53e04.r1
AA791143 vv91d10.r1
AI036012 vz68a09.r1
AA794692 vu63c06.r1
DIVLXXXXXXPKGNICVISIFGIHHNPSVWPDPEXXX
PFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEM
KVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ*
92% identical to rat CYP4F5 probable ortholog
Cyp4f16 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
AF233646 AK009445 no UNIGENE entry ESTs AA059667 mj77a08.r1
9097626 MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGM 9097823
9100841 IQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQA 9100981
9103307 ALVAPKDMTFLRFLKPWL 9103360
9103446 GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH 9103574
9104679 AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE 9104801
9105455 SPSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR 9105622
9105623 ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK 9105724
9106943 DEHGKELSDEDIRAEADTFMFGG 9107011
9107206 HDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEW 9107334
9110828 DDLAQLPFLTMCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPK 9110959
9111076 GNICVISIFGIHHNPSVWPDPE 9111141
9111306 VYDPFRFDPENPQKRSPLAFIPFSAGP 9111386
9111628 RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ* 9111807
Cyp4f17 mouse
GenEMBL ESTs AA387122 vc22e06.r1, AA386914 vc23b12.r1
AA387149 vc22f06.r1
MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWF
WGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQASAAVAPK
EMIFYGFLKPWLGDGLLVSAGEKWSRH
66% to CYP4F6 but 81% identical to a rat EST AI030199
The rat homolog to this gene has not been cloned yet.
Cyp4f17 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
AC073754 (5 exon 9s) no UNIGENE entry
9067942 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWFWGHMSM 9068139
9078921 VKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQAS 9079064
9081387 AAVAPKEMIFYGFLKPWLG 9081443
9081530 DGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMH 9081655
9083143 AKWQRLTTKGTACLDMLEHISLMTLDSLQNCVFSFDSNCQE 9083265
9085028 SPSEYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVH 9085171
9085172 NFTDAVIRERRRTLSSQNLDEFLKSKTKSKTLDFIDVLLLAK 9085297
9085604 DEHGKELSDEDIRAEADTFMFG 9085669
9085859 GHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW 9085990
9088714 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPK 9088845
9088918 GTDCVISIFGVHHNPEVWPDPE 9088983
9089148 VYDPFRFDPENPQKRSPLAFIPFSAGPR 9089231
9089587 RNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKPELILRAEGGLWLRVEPLSKGTQ* 9089766
Cyp4f18 frag.b mouse
GenEMBL ESTs AA716998 vu61b04.r1 AI006742 ua82h10.r1
frag. d AI006742 ua82h10.r1
PKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKXVVLA
frag. b AA716998 vu61b04.r1
LLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRD
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVIS
RISIFGTHHNPAVWPDPEV
Cyp4f18 fragments b and d 90% identical to 4F6, 89% to 4F4, 88% to 4F5, 87% to 4F1
complete sequence known but confidential (Henry Strobel)
Cyp4f18 mouse
GenEMBL NT_039466.1|Mm8_39506_30 - strand Chr 8
Note: not in the 4f gene cluster on chr 19
AF233647 AK007863 frag.b no UNIGENE entry EST AA716998 vu61b04.r1
138896 MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGL 138699
131761 IQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLA 131621
130374 PALVAPKDTVFYRFLKPWL 130318
130232 GDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMH 130104
127524 AKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQE 127402
125384 KPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDA
VIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSK 125115
122460 DEHGKALSDEDIRAEADTFMFG 122395
122191 GHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEW 122060
119223 DDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPK 119092
119002 GVISRISIFGTHHNPAVWPDPE 118937
118372 VYDPFRFDADNVKGRSPLAFIPFSAGP 118292
117969 RNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ 117793
CYP4F19 rat
GenEMBL AI030199
probable rat ortholog to 4f17 81% identical
opposite end of this clone = BF554573 N-terminal
4f17 1 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPS 56
MLQL LS LG GP PWQLL +VG SL LARIL WI AFYDNYCRLRCFP+PPS
4f19 1 MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS 56
4f17 53 EPPSRHWFWGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQA 113
+P SRHWFWGH+++VKNNEEGLQLL E SHQF D+HLCWIG FYPILRLIHPKFIG ILQA
4F19 53 QPLSRHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA 113
* one amino acid difference in overlap
sequence = MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS
RHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA
Cacgaggcattaacagagaagagcggaagtctctgggactcctgagaaaagg (start met)
atgctacagctgagcctg tcctgcctgg gccgggggcc agtgactgtc tccccatggc agcttctgct
ggtggttggg acctccttgc ttctggctcg aattctgggc tggatcagtg ctttctatga
caactactgc cgtctccgct gcttccctca gcccccttca
CGG CAC TGG TTT TGG GGT CAC TTG AAC TTG GTC AAG AAC AAT GAA GAA GGC CTG CAG TTG TTG GCT GAA ATG AGC CAC CAG TTC CAG GAT ATC CAC CTC TGT TGG ATT GGG ATC TTC TAC CCC ATC CTG AGG CTT ATC CAC CCC AAG TTT ATT GGC CCC ATA CTC CAG GCC
CYP4F20X starfish
Quoc Wu
Given its own subfamily renamed CYP4FA1
CYP4F21 sheep
no accession number
Johan Bylund
submitted to nomenclature committee 8/3/99
CYP4F22 human
GenEMBL AC011492
assembled gene 13 exons 114537-140651 66% to 4F3, 65% to 4F11, 63% to 4F2,
59% to 4F8, 64% to 4F12, 57% to AC011537 exact intron boundaries need checking no ESTs
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMVS
PNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGAS
AAIAPKDDLFYGFLKPWLG
DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMH
AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQE
KMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRR
ALRQQGAEAWLKAKQGKTLDFIDVLLLAR
DEDGKELSDEDIRAEADTFMFEG
HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW
DDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK
GIICLVSIYGTHHNPTVWPDSK
VYNPYRFDPDNPQQRSPLAYVPFSAGPR
NCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRPELILRTENGLWLKVEPLPPRA*
CYP4F22 Bos taurus (cow)
See cattle page for details
MLPITEQLLHLLGLEKTAFRLYAVSGLLLTLLFFLFRLLLQFLRLCWGFYITCRRLRCFPQPPRRNWLLGHLGM (0)
YLPNERGLQDEKKVLDDMHHVILVWLGPVLPLVVLVHPDYIKPLVGAS (1)
AAVAPKDDLFYGFLKPWL (1)
GDGLLLSRGDKWSRHRRLLTPAFHFDILKPYMKIFNQCADTMH (0)
AKWRGLAEGSEVSLDMFEHVSLMTLDCLQKCVFSYNSNCQE (2)
KMSDYISAIIELSALVVRRQYRLHHYLDFIYYRTADGRRFRQACDTVHGFTTEVIQERRR ALRQQGAEAWFKAKQGKTLDFIDVLLLAK (0)
DEDGKELSDEDIRAEADTFMFE (1)
GHDTTSSGLSWVLFNLAKYPEYQEKCREEIQEVMKGRELEELEWSGQ (2)
DDLTQLPFTTMCIKESLRQFPPVTLVSRRCTEDIKLPDGRIIPK (1)
GIICLVSIYGTHYNPAVWPDSK (0)
VYNPYRFDPDNPQQRSPLAYVPFSAGPR (2)
NCIGQSFAMAEMRVAVALTLLRFRLFLDRTRKVRRKPELILRTENGIWLKVEPLPPRA*
CYP4F23P human
GenEMBL AC011492
assembled gene 76% to 4F3, 76% to 4F8, 76% to 4F11, 73% to 4F2, 75% to 4F12,
77% to 4F11, 60% to other 4F on this accession no ESTs also on AD000091
MSLLSLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYAFYDNCHRLQCFQQPPKRNCF*GHLSLVS
GNEEDMRLMEDLGHYFRDVQLWWLGSFYPVLHLVHPTFTAPVLQAS AAVALKDMSFYGFLKPWLG
DGLLISAGDKWRWHRHLLTPAFHFKILKPYVKIFNESTNIMH
AKWQRLALEGSVRLEMFEHISLMTLDSLQKCIFSFDSNCQE
KPSEYIDAILELSALSLKRHQHIFLLTDFLYFLTPNGRRFCRACDIVHNFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLAK DENGKKLSDENIRAEADTFMSG
GHDTTASGLSWVLYNLARYPEYQEHCRQEVQELLKNGDPKEIEW
DDLAQLPFLTMCLKESLRLHSPVSRIHRCCPQDGVLPDGRVIPK GNTCTISIFGIHHNPSVWPDPEV
YDPFRFDPENLQKTSPLAFIPFSAVPR
NCIGQTFAMAEMKVVLALTLLRFRVLPDHAEPRRKLELIVRAEDGLWLRVEPLSADLQ*
CYP4F24P human
GenEMBL AC011537.4
77% to 4F11 missing last exon two in frame stops and a gap.
24346 MPQLSLSWLGLGQVAAFPWLLLLLAGASRLLAGFLAWTYAFYDNCRRLQYFPQPPKQKWF 24167
24166 WGQPGX 24152
6633 IIATEEGLKNLTQMSATYPQGFRIWLGPIFPFIVLCHPDIVRSITNAS 6788
8837 AAIAPKDDLSIRFLKPWLGEGILLSGGDK 9016
9017 WSRHRRMLTPAFHFNILKPYIKIFNRSVNIMH 9112
11018 DKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 11140
11921 RPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGWRFRRACRLVHDFTDAVIQERRH 12100
12101 TLPTQGI 12121
12115 CDFLKNKAKS*TLDFIDVLLLSKXXXXXXXXXXXXXXXXXXXXXX 12189
13460 GHDTTASGLSWVLYNLARHPEYQEHCRQEVQELLKDRDPKEIEWX 13591
21804 DLAQLPFLTMCVKESLRLHPPVPYTSRHRIWDIVLPDGRVIPK 21932
22019 GIICIINIIGIHHNPTV*PDPEV 22165
22263 YNPFRFNSENSKERSPLAFIPFSAGPR 22361
CYP4F25PX human
GenEMBL AC018949
62% to 4F3 pseudogene
new name = CYP4F-se1[6:8]
95242 LWRCFLSPTSPCRNPSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDL 95066
95065 VHNF 95054
95052 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 94936
GenEMBL NT_078056.1|Hs9_78125 chromosome
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940
CYP4F26PX Human
GenEMBL AL139008
Homo sapiens chromosome 9 clone RP11-255A11 81% TO CYP4F-se1[6:8]
New name = CYP4F-se2[6]
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
S+Y+AT+ EL ALIV*WHQQICLCMDFLYY PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549
CYP4F27PX human
GenEMBL AC018804.2
Homo sapiens clone RP11-397H17 62% TO CYPF25P
New name = CYP4F-se3[6:7:8]
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
CYP4F28 Fugu rubripes (pufferfish)
No accession number
Scaffold_2425
76% to 4F7
8381 MSVLQLALSWTSVCPLLAVLAAAPVALLTFWTAKLLVRHAWYTHRMACFSKPHARSWLLGHLGQ 8190 (0)
7561 MQSTEEGLLQVDELVQMFTYCCSWFIGPFYHLVRVFHPDYVKPLLMAP 7418 (1)
7238 ASITVKDELIYDHLRPWL 7185 (1)
7049 GNSLLLSNGEAWSRRRRLLTPAFHFDILKNYVTKFNTSTNTLH 6921 (0)
6727 DKWHRLLVEGTTNIEVFEHFTLMTLDSLLKCAFSYDSDCQQ 6605 (2)
6527 SSSEYASAIIELSDLIIERRQRILHHWDWIYWRTQQGKRFKKALSIVHK 6381 (2)
6307 FTRDVVQKRLALISQKGVAELAAHRKRDFVDIILLTK 6197 (0)
6115 DEDGKGLTDEELQAEANTFMFA 6050 (1)
5813 GHDTTASAICWSLYNLAHHNHYQEQCRQEVMDLMEGRDVDEIKW 5682 (2)
5607 EDLSSLPFTTMCIRESLRLHSPVQAVTRRYIQDVKLPGERTVPK 5476 (1)
5248 GAICLVSIYGTHHNPAVWTNPH 5183 (0)
5101 DFDPLRFDPKNQEGLSSHAFIPFSSGPR 5018 (2)
4948 NCIGQKFALAELRVVVALTLLRFRLLPGNDPKRETPFEKVRRLPQLVLRAEGGLWLQIKPVTQTQ* 4751
CYP4F29PX human
AL109748 chr 21
designated CYP4F3LP pseudogene Nature 405, 311-319 2000
new name = CYP4F-se4[6:7:8]
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW
CYP4F30P human
NT_022140.9|Hs2_22296 Homo sapiens chromosome 2
270169 RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLTSQGVDDFLKAKATFKA 269990
269989 SDFIDALVLSK 269957
CYP4F31P human
NT_019306.9|Hs2_19462 Homo sapiens chromosome 2
2940797 PEG*CFYKACDLVHNF 2940844
CYP4F32PX human
NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
New name = CYP4F-se5[6:8]
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
NT_022300.8|Hs2_22456 chromosome 2 88% to 4F25P
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
CYP4F33PX human
NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
New name = CYP4F-se6[6]
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
S+Y+AT+ EL ALIV*WHQQICLC DFLYY PEG CFC DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388
Query: 62 SQGVHDFLKTKATFKTWDFSDALVLGK 88
SQGV D LK KATFKT DF DALV K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310
CYP4F34PX human
NT_009799.9|Hs13_9956 Homo sapiens chromosome 13
New name = CYP4F-se7[6:7:8]
343178 DTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
Old name = 4F34P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
Length = 12392145
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725
Query: 32 PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
P P+G DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869
CYP4F35PX human
NT_010859.8|Hs18_11016 chromosome 18 4F pseudogene 84% to 4F12
chr18p11.21 14328070-14328279 + strand build 33
New name = CYP4F-se8[6:7:8]
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF G DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195
Query: 61 TSQGVHDFLKTKATFKTWDFSDALVLGK 88
TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899
CYP4F36PX human
NT_011281.4|Hs19_11438 chromosome lone last exon 75% TO 4F11
New name = CYP4F2-de12b
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448
Cyp4f37 mouse
AC073754 comp(28012-47256) also NT_039649.1
93% identical to 4f16, duplicate exon 6, fs in exon 7
MLRLSVSGLDLGSVVTLSWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGM
IEHNEEGMQLMTEAGQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLA TALVAPKDTTFHTFVKPWL
GDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH
AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE
SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR
ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK
DEHGKELSDEDIRAEADTFMFGG
HDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW
DDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VYDPFRFDPENAHKRPPLAFIPFSAGP
RNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLS
Cyp4f37-ie6b mouse
GenEMBL NT_039649.1 duplicate exon 6, incomplete
x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
9192951 SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHPADGR 9193064
9193067 FRKACD 9193084
>Cyp4f37-de1b mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
exon 1 22-60
z in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9142319 LLPFMAS*PLGRILAWTHFFYEVCACLICFPQAPKQNWF 9142435
>Cyp4f37-de7b8b mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
exons 7, 8
y in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9166323 DERGKELSDEDIWAEAYTFVFGR 9166391
9168358 XXXXXXALSWILYNLVRHPEYPECCLWEVQELLRDLNHEEIEX 9168465
Cyp4f38-ps mouse
AC073754 comp(9555-20475) also NT_039649.1
partial pseudogene 52% to 4f14
AHILIQVYAAYGNYPHIPKWNWLMGHVSM
PQRRARRMLLNW*GNYP*GFIL*MIPLVSILKPCHPGIAKSV
VSAGDKWSHHCHMLTPAFHFNILKLYVKIFNDSTNIVH
LNISDHVILMTLGNFQKCIFSFDSNCQD
AIMELSMLISRRNKEPLLHMDLLGHLTPDGMCCCKACSMMHGLDDAVI
QERGHILSRQGLDGFFKDKVKFKPLNFIAVLLLTK
DDMSQLPFLTMCISLWLHPPDLLISYYCI*DVVLPDGWIIPKG
Cyp4f39 mouse
AC073754 range 185296-209241, also NT_039649.1
minus strand 62% to 4F14
MLPLTDYLLQLLGLEKTAFRVYV
VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMVS
PNEKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGAS
AAIAPKDEFFYSFLKPWLG
DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMH
AKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVFSYNSDCQE
SMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDTVHNFTTEVI
QERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAK
DEEGKELSDEDIRAEADTFMFEG
HDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDW
DDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPK
GIICLVSIYGTHHNPIVWPDSK
VYNPYRFDPDTPQQRSPLAFVPFSAGP
RNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWLNVEPLPSRA*
Cyp4f40 mouse
AC073754 range <1-3688, also NT_039649.1
minus strand two N-terminal exons no ESTs
continues on AC073720 comp(118300-137027) 79% to 4F14
MRYLDLSWLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMVS
PTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSAS
SAAVAPKDDIFYSFLKPWL
GDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMH
AKWLRLASGGSTRLNMFENISLMTLDTLQKCVFSFNSNCQE
KPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDF
TDAVIQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTK
DEDGKELSDEDIRAEADTFMFRG
HDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEW
DDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPK
GVICIINIFGTHHNPTVWRDPE
VYDPFRFDPENIQARSPLSFIPFSAGP
RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSTQA
Cyp4f41-ps mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand
Pseudogene exons 5,6,9,10,12 189-216
9523155 NKWQCLTFESSASL 9523114
9523111 ALFEHMNLTTVDSLQKCVFSFHSNCQE 9523031
9521583 SNSKYIAAILELISFNSTSPSWMWTSCTNYLSVDG*CFHKACNLVDSFTDVVIT 9521422
9521421 TEGPCNLNTQGVDEFLKAKAKAKTLDFIDVLLKTR 9521317
9518053 NDLTQLPFLTMSMKESLRLHPPGSMISLCCIQDILLLDDLVISS 9517922
9517838 GHVC 9517827
9517828 VTSIFRSHHNPSVWPDPE 9517775
9517097 RNCIGLTFGHECNEDDDGADADAARFCVLPGDKGPRRLSALMLRTEGGLWLQVELLT 9516927
CYP4F42 Xenopus laevis
No accession number
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
64% to 4F22 in humans (full length)
CYP4F43P rat
pseudogene chr7 (+) strand exons 4, 5, 9, 10, 11, 12
between 4F37 and 4F40
13179984 RDGVFLISFDKWNHHHCLLTPAFHFDNLVL 13180073
*VKIFNQSVNIIH
13181413 VSFLKAKWKCLFSEGSACLEIFENLTTLDSLQKCLFSLDSNCQE 13181544
13207589 NDLAQLPFLTMCIKASLQLYPQDTNLICSCT 13207681
*DILLPDG*VIPK
XXXXXXXXXGVHHSPSVWTDPX
13208327 VYYPFPFDSKNPQKISPLAFMPFSVGP 13208407
13208782 RNCKRQTYPMSERKVALVLKLLHFHTIPGEIDPPRQPELILSLEGRLWLLKESLSVG 13208952
CYP4F44P rat
pseudogene MISSING EXON 1 AND HALF OF EXON 2 90% to 4f16
between 4F37 and 4F40
13215861 LGPVIPVLRLVDPAFVAPLLQAP 13215929
13219942 ALVAPKDMNFYGFLKPWL 13219995
13220082 GDGLLLSSGDKWNRHRXLTPAFHFDILKPYVKIFNQSVNIMH 13220206
13227610 VKWKHLCVEGSAHLEMFENISLMTLDSLQKCLFGFDSNCQE 13227732
13228571 SPSEYISAILELSSLTIKRSYQLFLYLDFLYYRTADGRRFRKAC
DLVHSFTDAVIRERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAK 13228846
13230087 DEHGKELSDEDIRAEADTFMFG 13230152
13230344 GHDTTASTLSWILYNLARHPEYQESCLQEVWELLRDREPEEIEW 13230475
13239583 DDLAQLPFLTMCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIPK 13239714
13239826 GNICVISIFGIHHNPSVWPDPE 13239891
13240051 VYDPFRFDPESRQKRSPLSFIPFSAGP 13240131
13240378 RNCIGQTFAMNEMKVAVALTLLRFRLLPDDKEPRRKPEIILRAEGGLRLLVEPLSGGA* 13240554
CYP4F45 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F2#1
87% to 4F11 human, 88% to 4F2 and 87% to 4F3
needs a separate name. Cannot identify the ortholog without map data
CYP4F46 Bos taurus (cow)
See cattle page for details
MLELSMSRLGLGLVAASPWLLLLVVGASWLLAHILAWTYTFFNNCRLLQCFPQPPKLNWFFAHLYL (0)
VPMTEQGLRKLTQLAANYSHGYMIWFGPITLMIVFCHPDMLRSITNAS
AAVAPKDMDFYNFLKPWLG
DGLLLSAGDKWSRHRCMLTPTFHFNILKPYMKIFTKSTDIMH
TNWECLVTQGHTRLDMFEHVSLLTLDSLQKCVFSFDSNCQE
KPSEYITTIFELCELAAKRNKQICLHTDFLYFLTLDGWHFRRACRLVHNFTDSIIQEQRCTLPSENI
DDFFKAKVKTKTLDFIDVLLLSK
DEDGKGLSDEE
IRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCGQEVKELLRDCESKEIEW
DDLAHLPFLTMCIKESPRLHPPVTFIFRYCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWPDPE
VYDPFRFDPENIKGRSPLAFIPFSAGSR
NCIGQTFAMTEMNVVLALTLLRFRFRPDKEEPRRKPELILRAEGGLWLQVELLSAGPQ*
CYP4F47 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLRPVAASPWLLLVLVGASWILAHVLAWTYTFYNNSRHLQCFPQPPKRNWFLGHMGQYPP
TEKGLRDFTQLVANYPQGFRICLGPAIPIIIFCHPDMIRIVANAS
AAAAPKDVIFYDFLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSADIMH
AKWQRLITEGHTHLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPNEYIASILELSALVAKRNQQIFLHMDFLYFLTPDWRRFRRACRLVHDFTDAVIQERRHTLPSEGT
DDFLKAKVKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWVLYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRYAQDTLLPDGRVIPK
GVICLINIIGTHHNPSVWPDPE
VYDPFRFEPENIKGRSPLAFIPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPGEEPRRKPELILRAEGGLWLRVEPLSADQ
CYP4F48 Bos taurus (cow)
See cattle page for details
MLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNL
VPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNAS
AAIAPKDMQFYGTLKPWLG
DGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMH
AKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQE
KPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWQDPE
VYDPFRFDPENIKGRSPLAFIPFSAGPR
NCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ*
CYP4F49 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLGPVAASPWLLLLFTGASWLLARILAWTYTFYNNSRRLQCFPQPPKRNWFLGHLGL
VPPTEQGMSKLTELVAKYSQGFRIWMGPITPIIVFCHPDLIRIVANAS
AAVAPKDVIFYEVLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSTDIMH
AKWQHLIKEGHTHLDMFEHISLMTLDSLQKCIFSYDSNCQE
KPSEYIAAILELSALVAKRHQEIFLHMDFLYYLTPDGRRFRRACRLVHDFTDAVIQERHRTLPSESI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHKEYQERCRQEVQELLKDREPKNIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRCTQDTVLPDGRVIPK
GVICLISIFGTHHNPSVWPDPE
VFDPFRFDPENIKGRSPVAFVPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPDKEEPRRKPELILRAEGGLWLRVEPLSTGQQ*
CYP4F50 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLGPVAASPWLLLLLVGASWILARILAWIYAFYDNCCRLRCFPQPPKRSWFWGHLGL
AQSNEESMRLVEELGHYFRDVHLWWMGPFFPILRLVHPNFVAPLLQAS
ATIIPKDMFFYSFLKPWLG
DGLLLSAGDKWSSHRRLLTPAFHFEILKPYMKIFNKSADIMH
AKWQRLALEGSTRLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPSEYIAAILELSALVMKRIKHIFLHVDFLYYLTRDGQRFYRACRLVHDFTDAIIQKRRRTLISQGS
QEFLKTKTKAKTLDFIDVLLLAK
DEDGKGLPDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDREPKEIEW
EDLAQLPFLTMCIKESLRLHPPVAVISRLCTHDVVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VFNPFRFDPEAPKRSPLAFIPFSAGPR
NCIGQTFAMNEMKVALALTLLRFRILPDEEEPRRKPELILRAEGGLWLQVEPLNTGQ*
CYP4F51 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4F52 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
77% to human 4F11, 81% to 4F49 cow
only 1 aa diff to AK233364 complete seq.
partial seq.
CYP4F52 Sus scrofa (pig)
AK233364
2 aa diffs to AK233483
MLQLSLSWLGLGPVEASPWLLLLLVGASWLLARVLVWTCTSLDNV
RRLRGFPQPPKPNWLLGHMGQVPPTEEGMTKLTQMMNTYPNGFMIWMGPITPIIVLCHPD
LIRTMANASAAVAPKDVVFYDFLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYMK
IFNDSVNVMHAKWQRLVTEGHNRLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYIAAI
LELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNTLPTEGIDD
FLKAKAKAKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWVLYNLA
KHPEYQERCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQD
IVLPDGRIIPKGVICLISIFGTHHNPLVWQDPEVYDPFRFDPENIKERSPLAFIPFSAGP
RNCIGQTFAMTEMKVVLALTLLRFRVLPVEEEPRRKPELILRAEGGLWLRVEPLSASPQ*
CYP4F53 pig
AK230568
85% to AK233364
MLQLSLSKMGLWLMAASPWLLLLLVGASWLLVQVLVW
TYTSYDNARRLRGFPQPPKRNWFLGHLGLIQSSEEGLLYTQDLASTYGDVCCWWVGPWHA
VIRIFHPTYIKPVLFAPAAIAPKASVFYDFLKPWLGDGLLLSAGDKWSSHHRMLTPAFHF
NILKLYMKNFNDSVNVMHAKWQHLVTEGHNRLDMFEHISLMTLDSLLKCVFSFHSNCQEK
PSQYIAAIVELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNT
LPTEGIDDFLKAKDKAKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTIMFGDHDTTASGL
SWVLYNLAKHPEYQECCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTV
ISRRCAQDIVLPDGRIIPKGVICLISIFGTHHNPSVWPDPEVYDPFRFDPENIKGRSPLA
FIPFSAGPRNCIGQTFAMTEMKVVLALTLLHFRVLPDKEEPRRKPELILRAEGGLWLQLE
PLSAGQQ*
CYP4F54 pig
AK238099
95% to AK233210 22 diffs
MLQLSLSWLGPGPVSASPWLLLQLVGATWLLSRILS
WIYDFYDNCCRLRCFPQPPKRNWFWGHWDLAKSNEEGLQLIEDMGRLFCDVYLWWLGPFY
PILRLVHPNFVAPLLQAPATIIPKDMLFYSFLKPWLGVGLLLSAGEKWSHQRRLLTPAFH
FDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSNCQE
KPSEYITAILALSALVIKRCEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQERRC
TLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTTASG
LSWVLYNLAKHPEYQERCRKEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHPPVP
GISRCCAQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKRSPL
AFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLWLRV
EPLRGGQQ*
CYP4F55 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
Three partial sequences called CYP4F6v1a,
CYP4F6v1b and CYP4F6v2 each have only 1 or 2
Amino acid diffs to the complete seq AK233210
These all appear to be from a single gene
CYP4F55v1 Sus scrofa (pig)
AK233210
5 aa diffs to AK239242 allele?
MLQLSLSWLGLGPVSASPWLLLQLVGATWLLSQ
ILSWIYDFYDNCCRLRCFPQPPKRNWFWGHRDLAKSNEECLQLMEDVGHYFHDVYLWWLG
PFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLSAGEKWSHQRRLLTP
AFHFDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSN
CQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQE
RRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTT
ASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHP
PVTGISRCCTQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKR
SPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLW
LRVEPLRGGQQ*
CYP4F55v2 Sus scrofa (pig)
AK239242, AK232426
5 aa diffs to AK233210
MLQLSLSWLGLGPVSASPW
LLLQLVGATWLLSRILSWIYDFYDNCCRLRCFPQPPKRNWFWGHQDLAKSNEECLQLMED
VGHYFHDVYLWWLGPFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLS
AGEKWSHQRRLLTPAFHFDILKSYVKIFNRSADIMHAKWQHLASEGHTRLDMFEHISLMT
LDSLQKCVFSFDSNCQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKA
CRLVHDFTDAVIQERRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIQ
AEADTFMFAGHDTTASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLP
FLTMCIKESLRLHPPVTGISRCCTQDVVLPDGRIIPKGNICVISIFGIHHNPSVWPDPEV
YNPFRFDPESPQKRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPR
RKPEIVLRAEGGLWLRVEPLRGGQQ*
CYP4F56 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
84% to 4F3 human, 88% to 4F49 cow, 94% to CYP4F52
15 aa diff to AK233364 CYP4F52 complete seq.
partial seq.
CYP4F-se1[6:8] human
GenEMBL NT_078056.1|Hs9_78125 chromosome 9
Length = 79560
Old name = CYP4F25P
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940
CYP4F-se2[6] human
GenEMBL NT_008413.15|Hs9_8570 Homo sapiens chromosome 9
Length = 39435727
Old name = CYP4F26P
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
S+Y+AT+ EL ALIV*WHQQICLCMDFLYY PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549
CYP4F-se3[6:7:8] human
AC018804.2 Homo sapiens clone RP11-397H17 62% TO CYP4F-se1[6:8]
chr2q21.1 130711641-130711907 - strand build 33
old name = CYP4F27P
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
Length = 4419942
3868414 SEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 3868235
3868234 SQGVDDFLKAKATFKASDFIDALVLSK 3868154
3867831 QDENGKELSDEDI*MEAGIFMSAG 3867760
3867566 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 3867447
chr2q21.1 130711641-130711937
4 DIFFS TO CYP4F-se3[6:7:8]
Query: 1 CFLSLASPCRNASELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTS 180
CFLSLASPCRNASE ADILELSTLIV*RRQ ICLC DFLYYPFLRGDASAGPVTWCTTS
Sbjct: 4 CFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTS 63
Query: 181 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 297
DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK
Sbjct: 64 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 102
CYP4F-se4[6:7:8] human
AL109748 designated CYP4F3LP pseudogene
Nature 405, 311-319 2000 chr21q11.2 14140950-14141905 + strand build 33
Old name = CYP4F29P
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW
CYP4F-se5[6:8] human
NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
chr2q11.1 94893656-94893866 + strand build 33
old name = CYP4F32P
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
NT_022300.8|Hs2_22456 chromosome 2 88% to CYP4F-se1[6:8]
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
NT_026970.9|Hs2_27130 Homo sapiens chromosome 2 genomic contig
Length = 2594449
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSAL+V*WHQQICLC DFLYY PEG CFCRA DLVHNF
Sbjct: 99822 PSEYIATILELSALLV*WHQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 99676
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ TLT +GV DFLK KATFK DFSDA +L K
Sbjct: 99674 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 99558
Query: 110 TGYDSTATGLY*ILCNLRRH 129
+GYDSTA+GLY IL NLRRH
Sbjct: 98986 SGYDSTASGLYWILYNLRRH 98927
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 98916 GVLPPRGARVLRDRNSEDIEW 98854
CYP4F-se6[6] human
NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
chr9p13.1 38532310-38532516 + strand build 33
old name = CYP4F33P
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
S+Y+AT+ EL ALIV*WHQQICLC DFLYY PEG CFC DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388
Query: 62 SQGVHDFLKTKATFKTWDFSDALVLGK 88
SQGV D LK KATFKT DF DALV K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310
CYP4F-se7[6:7:8] human
NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
Old name = CYP4F34P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
Length = 12392145
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725
Query: 32 PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
P P+G DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869
CYP4F-se8[6:7:8] human
NT_010859.8|Hs18_11016 chromosome 18
84% to 4F12 chr18p11.21 14328070-14328279 + strand build 33
old name = CYP4F35P
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF G DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195
Query: 61 TSQGVHDFLKTKATFKTWDFSDALVLGK 88
TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899
CYP4F-se9[6:7:8] human
NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
Length = 4419942 =
Old name = CYP4F30P
chr2q21.1 131102500-131102796
2 diffs with 4F31P
4259273 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 4259094
4259093 SQGVDDFLKAKATFKASDFIDALVLSK 4259013
4258690 QDENGKELSDEDI*MEAGIFMSAG 4258619
4258425 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 4258306
Query: 1 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60
SE IADILELSTLIV*RRQ ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT
Sbjct: 1 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60
Query: 61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120
SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL
Sbjct: 61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120
Query: 121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151
Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW
Sbjct: 121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151
CYP4F-se10[6:7:8] human
NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
Length = 18291257
Old name = 4F31P
chr2q21.1 132067957-132068253
2 diffs with CYP4F30P
654564 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 654743
654744 SQGVDDFLKAKATFKASDFIDALVLSK 654824
655147 QDENGKELSDEDI*MEAGIFMSAG 655218
655412 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 655531
CYP4F-se11[6:7:8] human
NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
Length = 18291257
Old name = CYP4F43P
chr2q21.1 131461272 131461568 5 DIFFS TO 27P 1 DIFF TO 4F32P
CFLSLASPCRNA
47879 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLT 48058
48059 SQGVDDFLKAKATFKASDFIDALVLSK 48139
48462 QDENGKELSDEDI*MEAGIFMSAG 48533
48727 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 48846
CYP4F-se12[6:8] human
NT_008251.13|Hs8_8408 Homo sapiens chromosome 8 genomic contig
Length = 5847381
Old name = CYP4F44P
chr8P11.1 43132635-43132941 + STRAND BUILD 33
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PS+YIAT+ ELSALI+* QQI L DFLYY EG CFCRAC +VHNF
Sbjct: 5439042 PSDYIATILELSALIM*RQQQIFLHRDFLYYVTAEGWCFCRACVVVHNF 5439188
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQGV++FLK ATFKT DF D LVL K
Sbjct: 5439190 DTIILEQHCTLTSQGVNNFLKVTATFKTLDFIDVLVLDK 5439306
Query: 111 GYDSTATGLY*IL 123
GYDSTA+GL+ +L
Sbjct: 5439892 GYDSTASGLFWVL 5439930
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P+ GA VLRDH+PEDIEW
Sbjct: 5439959 GVLPALGAGVLRDHSPEDIEW 5440021
CYP4F-se13[6:8] human
AC018949 62% to 4F3 pseudogene
found in two places 100% match
CYP4F-se1[6:8] chr9p11.2 43742181-43742487 (4F25P) + strand build 33
CYP4F-se13[6:8] chr9q13 63753376-63753682 (4F45P) + strand build 33
NT_078070.1|Hs9_78139 Homo sapiens chromosome 9 genomic contig
Length = 423701
0ld name = 4F45P
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 34719 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 34865
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 34867 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 34983
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 35569 GYDSTASGLYWILVPLRRHP 35628
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 35636 GVLPPRGARVLRDGNSEDIEW 35698
CYP4FA1 see bottom of Cyp4 family entries
4G Subfamily
Cyp4g1 Drosophila melanogaster
no accession number
Waters,L.C. personal communication (1993)
Note: called P450-A1 starts at amino acid 192 and goes to
the end.
Cyp4g1 Drosophila melanogaster
GenEMBL U34328(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4g1 Drosophila melanogaster
GenEMBL AL009188 comp (26402-24747) region genomic
Cyp4g1 Drosophila melanogaster
GenEMBL AC020093 comp(33262-34932) no introns
Cyp4g1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4G2v1 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen.
1996. Cytochrome P450 gene clusters in Drosophila
melanogaster. Mol. Gen. Genetics 251: 290-297.
Dta1
corrected from error, previously listed as 4G6
CYP4G2v1 Musca domestica (house fly)
no accession number (559 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee 1/5/98
CYP4G2v1 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #20-3
71% to Cyp4g1 65% to 4g13v2
1 aa diff to 4G2v1 Blomquist and Tittiger 1/5/98
CYP4G2v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #20-1
65% to 4g1 60% to 4g13
99% (4 aa diffs) to 4G2v1 plus 4 frameshifts
CYP4G3 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen. 1996.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251: 290-297.
Dt6-139
corrected from error, previously listed as 4G5
CYP4G4 Manduca sexta (tobacco hornworm)
GenEMBL AY635178.1
Snyder,M.J., Guzov,V.M., Stevens,J.L. and Feyereisen,R.
A CYP4G-like transcript expressed in the prothoracic glands of
Manduca sexta
Unpublished
CYP4G4 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4G5 Heliothis virescens(tobacco budworm)
no accession number (382bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G2
Hv-13a
CYP4G6 Heliothis virescens(tobacco budworm)
no accession number (386bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G3
Hv-1
CYP4G7 Tribolium castaneum (red flour beetle)
GenEMBL AF265300
Jeff Stuart
R39
submitted to nomenclature committee
TAAASSFFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQ
MKYLERVLLETLRMYPPVPIITRVINEEVKLASGDYTLPVGTTVGIGQFLVHRNPKYF
PNPDKFDPDNFLPERCQQRHYYSY
CYP4G7 Tribolium castaneum (red flour beetle)
GenEMBL XP_975951
MVVVEESLNHSLNLGNSVLISLGVVAVILAVYHFWLQSLRYTKLGNKIPGYDPLPIIGNAHMVMNKNPTQ
VMELALRVASEKGSVVRFWFGSKLGVALLDPRDIELILGSNVHLEKSSEYRFFEPWLGDGLLISKGDKWR
SHRKMIAPTFHQSILKTFVPVFNKNAMDLVEQLRNEALDQICDVHDYLSGATVDVLLETVMGVKKTKEAR
TSYKYAKAVMDMCTILHFRHVKLWLRSDWIFSFTKLFKEQTSLLRIIHNLTDRVIKQKKKETEEENLKIK
NEQTFNFGSGLRDDLDENDENLGEKKRLAFLDFMVEASQTEGNKLNDEEIREEVNTIMFEGHDTTAAASS
FFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQMKYLERVLLETLRMYPPVPIITRVINEEVKLA
SGDYTLPVGTTVGIGQFLVHRNPKYFPNPDKFDPDNFLPERCQQRHYYSFIPFSAGPRSCVGRKYAMLKL
KILLASIVRNFKIKSVVKEKDFQLQADIILKRADGFRVILTSRT
CYP4G8v1 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86002
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp24
submitted to nomenclature committee
CYP4G8v1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
86% to 4G15 C-term frag. 98 aa seq #3 HaCypZ006a-v2Pep
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 1 aa diff outside the primer region
CYP4G8v1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_179 has 3 aa diffs to HAH002281
74% to CYP4G36 Aedes
100% to partial CYP4G8 HaCypZ006a-v2Pep
HAH002281 has 3 aa diffs to Contig_179
CYP4G8v2 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp433
submitted to nomenclature committee
CYP4G8v3 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp477g
submitted to nomenclature committee
CYP4G8v4 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp73g
submitted to nomenclature committee
CYP4G9 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86003
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp60
submitted to nomenclature committee
CYP4G9 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
78% to 4G17 C-term frag. 261 aa seq #5 HaCypZ008a-v1Pep
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 1 aa diff outside the primer region.
CYP4G9 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
correct version 60% to CYP4G17, 3 aa diffs to CYP4G9
Contig_165 is missassembled, 1 aa diff to CYP4G9 of Grubor
Contig_166 1 aa diff to Contig_165 1 aa diff to CYP4G9 of Grubor
CYP4G10 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86004
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp5g
submitted to nomenclature committee
CYP4G10X Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
78% to 4G17 C-term frag. 100 aa seq #13
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 3 aa diffs outside the primer region to 4G10
revised longer sequence is diffferent from 4G10 renamed CYP4G26
CYP4G11 Apis mellifera (honey bee)
GenEMBL AF207948
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 18Am
CYP4G11v2 Apis mellifera mellifera (honeybee)
No accession number
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 9Am only 2 amino acid differences, one in EXXR motif, possible PCR
errors
CYP4G12 Trichogramma cacÏciae (a parasitoid wasp)
GenEMBL AF207949
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 3Tc 76% identical to CYP4G8
clone 6Tc is identical to 3Tc in the coding region but not in a short
intron this probably represents a recent gene duplication rather than an
allele
CYP4G13 Musca domestica (house fly)
no accession number
Xiaohua Shen, Gary Blomquist
68% identical to 4G1 full length, but different from 4G2 fragment (75%)
and 4G3 fragment (71%)
submitted to nomenclature committee 10/9/98
CYP4G13v2 Musca domestica (house fly)
GenEMBL AF355145.1
Nannan Liu
98% identical to 4G13, may be same gene with some errors between the
two
submitted to nomenclature committee 7/29/99
CYP4G14 Tribolium castaneum (red flour beetle)
GenEMBL AF263514
Jeff Stuart
S19
submitted to nomenclature committee
TAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFADTLE
MKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYY
PNPDKFDPDNFLPERTANRHYYSFI
CYP4G14 Tribolium castaneum (red flour beetle)
GenEMBL XP_973423, AF263514, AAJJ01000136
82% to 4G29 (shortened N-term in gene model)
MSTTVPTPDISTPSGILSASNVFYFLLIPALLLWYAYWRISKRHMLELAAKIPGPPGLPILGNALDLVGKPH 99617
99569 VFSHVYQKSFEYKKVVKMWAGPKLLVFLTDPSDIELILSSYVHIDKSSEYRFFKPWLGDG 99390
99389 LLISTGQKWKAHRKLIAPTFHLNVLKSFIDLFNANSRDVIRKLQKEIGKEFDCHDYMSEATVEMLL 99192
ETAMGVSKKTQDQSGYDYAMAVMKMCDILHLRHTKFWLRPDIIFNQTKYAEYQKSLINTIHSLTRKV
IKRKRADFDKGIRGSTAEVPPELQTKNYDKTESKTVVEGLSYGQSAGLKDDLDVDDNDIGEKKRMAFLDL
MIEASQNGVVINDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFA
DTLEMKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYYPNPDKFDP
DNFLPERTANRHYYSFIPFSAGPRSCVGRKYAMLKLKILLSTILRNYRIYSDLKEKDFQLQGDIILKRAE
GFKVRLEPRKMAKA
Cyp4g15 Drosophila melanogaster
GenEMBL AF159624
M. Ma•bche, D. Bšcking, S. Aragon and C. Dauphin-Villemant.
submitted to nomenclature committee 6/15/99
ESTs AI134510, AI388987, AI403684
Cyp4g15 Drosophila melanogaster
GenEMBL AC013897 comp(8972-10574 and 5306-6643) two pieces
Cyp4g15 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4G16 Anopheles gambiae
GenEMBL AY062189
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450A
79% identical to 4G8
CYP4G16 Anopheles gambiae (malaria mosquito)
GenEMBL AY062189
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x5
CYP4G17 Anopheles gambiae
GenEMBL AY062200
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450L
69% identical to 4G9
CYP4G17 Anopheles gambiae (malaria mosquito)
GenEMBL AY062200
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x3
CYP4G18 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF243507
Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
Insecticide Resistance Associated Cytochrome P450 Gene Fragments
from D. v. virgifera
Unpublished
DvP450-2
CYP4G19 Blattella germanica (German cockroach)
GenEMBL AY176056.1
Nannan Liu
Submitted to nomenclature committee 9/24/02
About 65% identical to Cyp4g15
CYP4G20 Mamestra brassicae (moth)
GenEMBL AY390259
Martine Maibeche
73% to 4G16
submitted to nomenclature committee Sept. 12, 2003
CYP4G21 Anopheles funestus
GenEMBL AY648704
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 4
94% to 4G17 probable ortholog of 4G17
CYP4G22, 23, 24 Bombyx mori (silkworm moth)
No accession number
These genes are on one contig but the gene order is not known yet
The names are assigned without knowing the order
CYP4G22 Bombyx mori (silkworm)
AV404689 prothoracic gland EST spans two contigs
AV405174 prothoracic gland EST
AV404871 prothoracic gland EST
BP183989 P5PG cDNA clone
BP182770 cDNA clone NRPG1026
BP182055 NRPG cDNA clone
BP183011 cDNA clone NRPG1327
BP183771 P5PG cDNA clone
AU004478 EST
BP183321 NRPG cDNA clone
BAAB01118673.1 BAAB01085960.1 84% to 4G20
64% to 4G19
Temp name 4Gxx
MSYTNAENVVPTSTFSAINLFYVLLVPAVILWYAYWRMSRRRLYELADKLNGPPGLPLLGNALEFVGGSA ()
DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLIST (1?)
GQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFDCHDYMSECTVEILL (1)
234 ETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 431 (0)
988 VIKRKKEEFASGKKPSNLNETATTSEPSTGKLTSVEGLSFGQSSGLKDDLDVDDDVGQK 1164
1165 KRLAFLDLLLESSQSGVAISDEEIKEQVDTIMFE 1266 ()
1340 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMET 1516
1517 LRLYPPVPIIARQVNQEITL 1576 ()
1680 SNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCV 1862 (1)
1960 GRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPRKRMAKA* 2136
CYP4G23 Bombyx mori (silkworm)
CK508129 rswdd0_001928.y1 swd cDNA
CK505752 rswcc0_009305.y1 swc cDNA
AV401408 BP122820 BP123076 BP183420 CK509955 CK505752 CK505553
BAAB01050777.1 BAAB01096227.1 BAAB01156775.1 BAAB01003438.1
BAAB01073763.1 BAAB01110168.1 BAAB01050777.1
58% to 4G19 59% to CYP4G22
Temp name 4Gyy
MTSLVDETEGYHVNSRVIFYPLLGLTTAIWILYRWQQNSHMHKLAELLPGPASIPIFGNALTLMRKNPHE ()
LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISS (1?)
GPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGTTVDILL ()
ETAMGISRKTQDESGFDYAMAVMK ()
MCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK ()
VIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDV ()
GEKKRLAFWDLMIESSQNGTNKISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYL
ERVILESLRLYPPVPVIARKLNRDVTI ()
STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKILLSTILRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPRKRVPTNVAR*
CYP4G24 Bombyx mori (silkworm)
BAAB01149226.1 BAAB01135847.1 BAAB01073803.1 BAAB01199362.1
FIRST TWO EXONS ARE JOINED WITHOUT OVERLAPPING EVIDENCE
BUT THEY ARE THE ONLY OTHER 4G N-TERM SEQUENCES WITHOUT A PARTNER
71% TO CYP4G23
Temp name CYP4Gzz
MSSLLNYNFEFDVPPIFHTLLLAIMIMWM
LHRWQQSSRLFRLGNKLPGPMALPLVGNSLLILGKKAEGW = BAAB01031491.1
VKYALDYSEKYG
TVVRAWAGPKLVVFLTDANDVEVILNSQIHIDKSPEYRFFKPWLGEGLLISSG = BAAB01016193.1
XKWRSHRKMIAPTFHINILKSFMGVFNENSKSVVKKLRSEVGKTFDVHDYMSCVTVDILL
ETAMGITKTTQDAASFDYAMAVMK
MCNIIHQRHYKVWLHFDAIFKLTSLFKKQRELLKTIHGLTNK (0)
VIKKKKFMYLQNKEKGIIPPTIEELTKIKDTNDSIMEDSAKTLSDTVFKGYRDDLDFNDEQDV ()
GEKKRLAFLDLMIESAQNHTCNISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQEIQSKV
YDELFEIFGDSDRLVTFADTLQMKYLERVILESLRLYPPVPAIARKLTRDVQI ()
VTNNYIIPAGSTVVIGTFKIHRDPKYHKNPNVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKVLLSTILRNYKTTSEISEDQFVLQADIILKRYDGFKIRIEPRNKNHSNTV*
CYP4G25 Antheraea yamamai (Japanese oak silkmoth)
GenEMBL AB196795
Yang,P., Onodera,C., Abe,S., Saito,N., Tanaka,H. and Suzuki,K.
Molecular cloning and nucleotide sequence of a cytochrome P450 cDNA
from the wild silkmoth, Antheraea yamamai.
Unpublished
87% to the silkworm seq temporarily named CYP4Gxx (see silkworm seqs)
CYP4G26 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ013a-v2Pep
Previously assigned to CYP4G10, but the longer sequence is not 4G10
478aa almost complete, 79% to 4Gyy silkworm 80% to 4G10
CYP4G26 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_174 has 1 aa diff to HAH004055 61% to CYP4G17,
6 aa diffs to CYP4G26 HaCypZ013a-v2Pep partial seq
HAH004055 has 1 aa diff to Contig_174
Contig_215 100% to HAH004055 C-term, 2 aa diffs to CYP4G26 of Heckel
CYP4G27 Ips paraconfusus (California fivespined ips, bark beetle)
GenEMBL DQ471883
Dezene Huber
Submitted to nomenclature committee May 19, 2005
65% to 4G22, full length
CYP4G28 Papilio polyxenes (black swallowtail butterfly)
No accession number
Zhimou Wen, Mary Schuler, May Berebaum
Submitted to nomenclature committee June 17, 2005
85% to 4G22 of silkworm
CYP4G29 Leptinotarsa decemlineata (Colorado potato beetle)
GenEMBL DQ117464
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
65% to 4G15, 74% to 4G28
CYP4G29 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G294419
65 amino acids from heme to end
CYP4G30 Spodoptera litura (common cutworm)
GenEMBL DQ350811
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RAG3 81% to 4G23
CYP4G31 Spodoptera litura (common cutworm)
GenEMBL DQ350813
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SC2: 80% to 4G23
CYP4G32 Spodoptera litura (common cutworm)
GenEMBL DQ350812
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SD2: 78% to 4G23
CYP4G33 Chironomus tentans (aquatic midge)
GenEMBL AY880065
Londono,D.K., Siegfried,B.D. and Sarath,G.
Induction of cytochrome P450 family 4 by atrazine in Chironomus
tentans
Unpublished
62% to 4G17
CYP4G34 Leptinotarsa decemlineata (Colorado potato beetle)
GenEMBL DQ631644
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G2535138
61 amino acids from heme to end
67% to 4G17, 62% to 4G7, 60% to 4G29
CYP4G35 Aedes aegypti (yellow fever mosquito)
CYP4G35 Culex pipiens
CYP4G36 Aedes aegypti (yellow fever mosquito)
CYP4G36 Culex pipiens
CYP4G37 Spodoptera exigua Hubner (beet armyworm)
GenEMBL EF113593
Mo Jianchu
Submitted to nomenclature committee Oct. 30, 2006
98% to 4G31
151 aa fragment
CYP4G38 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-9, 70% to 4G29 Leptinotarsa decemlineata (Colorado potato beetle),
68% to 4G28 Papilio polyxenes
Pediculus genome site
CYP4G39 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-1, 54% to 4g15 Drosophila, 56% to 4G16 Anopheles,
56% to 4G11 Apis, 57% to 4G29 Leptinotarsa decemlineata
Pediculus genome site
CYP4G40 Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
88% to 4G11 Apis
CYP4G41 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
84% to 4G11 Apis
CYP4G42 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
85% to 4G11 Apis
CYP4G43 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4G44 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4G45 Bombyx mori (silkworm)
No accession number
See silkworm page for details
CYP4G46 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0090J16 (531 aa, missing N-term)
82% identical to Drosoph. Cyp4g15
CYP4G47 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_c636
86% to 4G28 Papilio polyxenes
CYP4G48 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_2363
74% to 4G23 Bombyx mori
CYP4G49 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4G50 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
4H Subfamily
CYP4H1 Anopheles albimanus (mosquito)
GenEMBL L38682 (382bp) PIR PC2261 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H2 Anopheles albimanus (mosquito)
GenEMBL L38683 (382bp) PIR PC2262 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H3 Anopheles albimanus (mosquito)
GenEMBL L38684 (382bp) PIR PC2263 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H4 Anopheles albimanus (mosquito)
GenEMBL L38685 (382bp) PIR PC2264 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H5 Anopheles albimanus (mosquito)
GenEMBL L38686 (382bp) PIR PC2265 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H6 Anopheles albimanus (mosquito)
GenEMBL L38687 (452bp) PIR PC2266 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H7 Anopheles albimanus (mosquito)
GenEMBL L38688 (382bp) PIR PC2267 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H8 Anopheles albimanus (mosquito)
GenEMBL L38689 (461bp) PIR PC2268 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H9 Anopheles albimanus (mosquito)
GenEMBL L38690 (406bp) PIR PC2269 (135 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H10 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R26
submitted to nomenclature committee
CYP4H11 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R18
submitted to nomenclature committee
CYP4H12v1 Culex pipiens pallens (mosquito)
GenEMBL AF157091
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 125 amino acids
clone name NYDR1 73% identical to 4H7
this sequence has three frameshifts and some poor quality sequence at
the 5 prime end
MFEGHDTTTSGIAFTILQLAKHQHLRQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYF
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYIPFWAGPRNCIGH
CYP4H12v2 Culex pipiens
AF191731
Changliang Zhu
Clone NYDR19 PCR fragment 100% aa identical to NYDR18
98% identical to 4H12v1
1 aa diff to 4H12v4
Submitted to nomenclature committee 9/30/99
This seq was accidentally named CYP4H23v1
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYI
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYI
CYP4H12v4 Culex pipiens pallens
CB074950.1
NJS1618(7) 497bp, NJ007 in Genbank entry
96% to CYP4H12v5, 6 diffs, 73% to 4H24
99% to 4H12v3 97% to 4H12v1
NSLVIEVDTFMFEGHDTTTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYN
NLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDVY
PDPERFDPERFAEGSEQQQRREPYDYIPFSAGPRNCIGQNRIPAA
CYP4H12v5 Culex pipiens pallens
CB074949.1
NJS1618(9) 496bp, NJ006 in Genbank entry
96% to NJS1618(7) 6 diffs 71% to 4H24 96% to 4H12v3 95% to 4H12v1
GRGNSIEVDTFMFEGHDTTTSGIALTILQLAKHQDLQQKVYDEIVAILGQEGSKTTPLTY
NNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGRDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYIPFTAGPRNCIGQNH
CYP4H13 Culex pipiens pallens (mosquito)
GenEMBL AF160259
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 151 amino acids
clone name NYDR3 74% identical to 4H5
This sequence has a retained intron
EVDTFMFEGHDTTTSRISFTIWHLAKYQDVQQRLYEEIDRILGE
DKKHAELTNLKVQESEYLDMVVKESLRLIPPVPIIGRCLLEDMEM
DGVTIPAGTNISIKICNIHTNPKIRPNPEKFDPERFSKTNEDKRGPYDYIPFW
AGPRNCIG
CYP4H14 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450P
94% identical to 4H8
CYP4H14 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r1
CYP4H14 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
92% to 4H14 A. gambiae probable ortholog, 58% to 4H24
also 92% to 4H8 A. albimanus, probable ortholog
CYP4H15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450B
77% identical to 4H3
CYP4H15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r2
CYP4H15v2 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Y
one amino acid difference with 4H15, DNA is 95% identical
CYP4H16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450C
78% identical to 4H6
CYP4H16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r1
CYP4H17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450D
83% identical to 4H16
CYP4H17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r3
CYP4H18 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450G
77% identical to 4H16
CYP4H18 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r2
CYP4H19 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450K
78% identical to 4H7
CYP4H19 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPa1x1
CYP4H20X Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450O
50% identical to 4H5, 4H7
note the 4H subfamily might really be considered two differernt
subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.
4H20 falls between these.
Renamed CYP4D22
CYP4H21v1 Culex pipiens
AF208660
Changliang Zhu
Clone NYDR15 PCR fragment 79% identical to 4H13
Submitted to nomenclature committee 9/30/99
TTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNVKI
QEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMDGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDFI
CYP4H21v2 Culex pipiens pallens
CB074948.1
NJS1618(10) 487bp, NJ005 in Genbank entry
98% to CYP4H21v3, 3 diffs, 72% to 4H18, 97% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDRRGPYDYIPFTAGPRNCIGQNH
CYP4H21v3 Culex pipiens pallens
CB270837.1
NJS1618(11) 487bp, NJ009 in Genbank entry
98% to CYP4H21v2, 3 diffs, 71% to 4H18, 96% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINTKIYDIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDYIPFTAGPRNCIGQNH
CYP4H22v1 Culex pipiens
GenEMBL AF190782
Changliang Zhu
Clone NYDR7 PCR fragment 96% identical to 4H22v2, 57% to 4H3
Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNTAVQHKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGHKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEENSSKRHPYAYV
CYP4H22v2 Culex pipiens
AF190784
Changliang Zhu
Clone NYDR9 PCR fragment 96% identical to 4H22v1
Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNPAVQQKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEESSSKRHPYAYV
CYP4H22v3 Culex pipiens pallens
CB074946.1
NJS1618(3) 483bp, NJ003 in Genbank entry
56% to CYP4H12v4, 64% to 4H15, 96% to 4H22v2
NSLVIEVDTFMFEGHDTTTSCISFAAYHIARNPAVQQKLYDKMVQVLGPDFENAQLTYSN
LQELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVFP
EPTRFDPERFNEENSSKRHPYASVPFTAGPRNCIGQNRIPAA
CYP4H23v1X Culex pipiens
AF191731
Changliang Zhu
Clone NYDR18 PCR fragment 100% amino acid identical to 4H23v2
Submitted to nomenclature committee 9/30/99
Note: these sequences are 50% to 4D14 and 47% to 4H7,
But they sort to the 4H cluster on a tree.
1 aa div to 4h12v4, 2 aa diffs to 4H12v1
This seq is 100% identical to CYP4H12v2 not a 4H23 seq
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYNN
LNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYI
CYP4H23v2 Culex pipiens
AF190787
Changliang Zhu
Clone NYDR12 PCR fragment 100% amino acid identical to 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVSLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H23v3 Culex pipiens
AF191729
Changliang Zhu
Clone NYDR17 PCR fragment 1 diff to 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVTLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H23v4 Culex pipiens
GenEMBL AF190783
Changliang Zhu
Clone NYDR8 PCR fragment 2 diffs with 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNISKQVSLAGLTVPPNTSISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H24 Anopheles Gambiae (mosquito)
No accession number
Hilary Ranson
Submitted to nomenclature committee 10/15/2001
82% to CYP4H7
clone name Cyp43_3
CYP4H24 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPa1x2
CYP4H25 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r3
CYP4H26 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r4
CYP4H27 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3r1
CYP4H28 Aedes aegypti (yellow fever mosquito)
CYP4H28 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.2
CYP4H29 Aedes aegypti (yellow fever mosquito)
CYP4H29 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4I1.8
CYP4H30 Aedes aegypti (yellow fever mosquito)
CYP4H30 Culex pipiens
CYP4H31 Aedes aegypti (yellow fever mosquito)
CYP4H31 Culex pipiens
CYP4H32 Aedes aegypti (yellow fever mosquito)
CYP4H33 Aedes aegypti (yellow fever mosquito)
CYP4H34 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 4
58% to CYP4H31 Aedes, 66% to 4H12v5 and 4H12v4
CYP4H34 Culex pipiens
CYP4H35 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 8
74% to 4H29 Aedes, 59% to 4H15 Anoph., 59% to 4H25 Anoph.,
40% to 4D1, 44% to 4H34, 45% to 4D40
The 4H subfamily seems to need to be split
CYP4H35 Culex pipiens
CYP4H36 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 9
72% to 4H29 Aedes, 60% to 4H15 Anoph., 44% to 4H34
CYP4H36 Culex pipiens
CYP4H37 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 10
62% to 4H19 Anoph., 62% to 4H31 Aedes, 59% to 4H34
CYP4H37v1 Culex pipiens
CYP4H37v2 Culex pipiens
CYP4H38 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 16
70% to 4H18 Anoph., 79% to 4H33 Aedes, 53% to 4H34
CYP4H38 Culex pipiens
CYP4H39 Culex pipiens
CYP4H40 Culex pipiens
CYP4H41 Culex pipiens
CYP4I I and O are not used in this nomenclature
4J Subfamily
CYP4J1 Anopheles albimanus (mosquito)
GenEMBL L38691 (433bp) PIR PC2258 (124 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J2 Anopheles albimanus (mosquito)
GenEMBL L38692 (397bp) PIR PC2259 (132 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J3 Anopheles albimanus (mosquito)
GenEMBL L38693 (385bp) PIR PC2260 (128 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J4 Culex pipiens
CPIJ016284
CYP4J4v1 Culex pipiens pallens (mosquito)
AF157092
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 149 amino acids
clone name NYDR4 63% identical to 4J2
EVDTFMFEGHDTTASALVFIFFQLAREQTVQEHIFNEIHALYDR
KPQADKSFRPQDYAELKFMDRALKECLRLWPPVTFISRAITDDIILADGALLPAGCVG
NVQIFDLHRDPEQFPDPERFDPDRFLPESVDKRNPYAYVPFTAGPRNCIG
CYP4J4v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDS5 PCR fragment 96% identical to 4J4v1
Submitted to nomenclature committee 9/30/99
TASALVFIFFQLAREQTVQERIFNEIHALYDRKPQADKSFRPQD
YAELKFMDRALKECLRLWPPVTFISRAITDDIVLADGALLPAGCVANVQIFDLHRDPE
QFPDPERFDPDGFLPESVDKRNPYAYV
CYP4J5 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450J
66% identical to 4J2
CYP4J5 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l2
CYP4J6 Culex pipiens
CPIJ001754
CYP4J6v1 Culex pipiens
GenEMBL AF190776
Changliang Zhu
Clone NYDS3 PCR fragment 95% identical to 4J6v2, 59% to 4J3
Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLCDEIEASSPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADHFVPKGSMANVHIWDLYRDPEQFPDPE
RFDPDRFLPENVEKRNPYAYV
CYP4J6v2 Culex pipiens
AF190781
Changliang Zhu
Clone NYDR6 PCR fragment 95% identical to 4J6v1
Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLYDEIEASRPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADRFVPKGSMANVHIWDLHRDPDQFPDPE
RFDPDRFLPESVEKRNPYAYV
CYP4J7v1 Culex pipiens
GenEMBL AF190780
Changliang Zhu
Clone NYDR5 PCR fragment 96% identical to 4J7v2, 60% to 4J3
Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNELRYMDRVIKECLRLYPPVPFIGRMINEDSWFGDRFIPKDSMANVLIWDLHRDPKQ
FLDPERFDPDRFLPENVGQRNPYAYV
CYP4J7v2 Culex pipiens
AF190785
Changliang Zhu
Clone NYDR10 PCR fragment 96% identical to 4J7v1
Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNEFRYMDRVIKECLRLYPPVPFIGRMINEDSWFGYRFIPKDSMANVLIWDLHRDPRQ
FLDPERFDPDRFLPENVEQRNPYAYV
CYP4J8v1 Culex pipiens
GenEMBL AF190788
Changliang Zhu
Clone NYDR13 PCR fragment 61% identical to 4J6v2
Submitted to nomenclature committee 9/30/99
TGSAFVFIFLSIANHQDVQERVYQEVHATLHDRSGPAEPLTIQD
YNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQ
FPDPERFDPDRFLPEHVEKRNPYAYV
CYP4J8v2 Culex pipiens pallens
CB074944.1
NJS16171(1) 490bp, NJ001 in Genbank entry
98% to 4J8v3, 3 diffs, 61% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDVQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRYVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFSAGPRNCIGQNRIPAA
CYP4J8v3 Culex pipiens pallens
CB074947.1
NJS1618(8) 490bp, NJ004 in Genbank entry
98% to CYP4J8v2, 3 diffs, 59% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDDQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFTAGPRNCIGQNRIPAA
CYP4J9 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l1
CYP4J9 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
88% to 4J9 A. gambiae probable ortholog, 56% to 4J5
CYP4J10 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l3
CYP4J11 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 1
79% TO 4J5 57% TO CONTIG 7 probable ortholog of 4J5
60% to 4J9 and 58% to 4J10
CYP4J12 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 6 and contig 7 (1 aa diff)
83% TO 4J10 54% to 4J9 and 53% to 4J5
probable ortholog of 4J10
CYP4J13 Aedes aegypti (yellow fever mosquito)
CYP4J13 Culex pipiens
CYP4J14 Aedes aegypti (yellow fever mosquito)
CYP4J15v1 Aedes aegypti (yellow fever mosquito)
CYP4J15v2 Aedes aegypti (yellow fever mosquito)
CYP4J16 Aedes aegypti (yellow fever mosquito)
CYP4J17 Aedes aegypti (yellow fever mosquito)
CYP4J18 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 14
68% to 4J16 Aedes, 54% to 4J9 Anoph.
CYP4J18 Culex pipiens
CYP4J19 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 12
59% to 4J9 Anoph., 71% to 4J19 Aedes
CYP4J19 Culex pipiens
CYP4J20 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 13
54% to 4J5 Anoph., 50% to 4J13 Aedes
CYP4J20 Culex pipiens
4K Subfamily
CYP4K1 Anopheles albimanus (mosquito)
GenEMBL L38694 (379bp) PIR PC2273 (126 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4K2 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
73% to 4K1 fragment
SLRAICLH sequence not seen in 4K1 probably bad
joint
CYP4K2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r1
Note very similar to CYP4AR1 (almost in the same subfamily)
CYP4K3 Aedes aegypti (yellow fever mosquito)
CYP4K3 Culex pipiens
4L Subfamily
CYP4L1 Manduca sexta (tobacco hornworm)
GenEMBL L38668 (391bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4L2 Manduca sexta (tobacco hornworm)
GenEMBL L38669 (394bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4L2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4L3 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Kate Aronstein and Richard ffrench-Constant
submitted to nomenclature committee
called evacyp4
CYP4L4 Mamestra brassicae (moth)
GenEMBL AY063501
Martine Maibeche
59% to 4L1 (partial seq)
clone name MbraC5 full length
submitted to nomenclature committee Oct. 5 2001
CYP4L5 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
100% identical to Grubors seq
CYP4L5 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #9 HaCypZ012a-v1Pep
85% to 4L4
CYP4L5 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_173 100% to CYP4L5
HAH001637 100% to Contig_173, 1 aa diff to Contig_172
Contig_172 1 aa diff to Contig_173
HAH001562_2 1 aa diff to Contig_173
Contig_186 1 aa diff to Contig_173
CYP4L6 Bombyx mori (silkworm)
CK535040 BP182824 ESTs
BAAB01121615.1 BAAB01097697.1 BAAB01093085.1 BAAB01107041.1
See silkworm page for sequence
CYP4L7 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee July 26, 2004
75% to 4L4
CYP4L8 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A4
78% to CYP4L4, 91% to CYP4L7
CYP4L9v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SA3 97% to 4L9v2, 3 aa diffs,
87% to 4L4, 91% to 4L7, 88% to 4L8
CYP4L9v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RAG1 97% to 4L9v1, 3 aa diffs,
87% to 4L4 89% to 4L7 86% to 4L8
CYP4L9 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to CYP4L13, 80% to CYP4L12, 77% to 4L5
86% to 4L7, 78% to 4L4, 97% to 4L9v1 (4 aa diffs,
probable ortholog), 95% to 4L9v2 (6 aa diffs)
89% to 4L8, 88% to 4L10
CYP4L10 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RT5 98% to 4L8 2 aa diffs,
78% to 4L4 possible ortholog of 4L8
CYP4L10 Spodoptera litura (common cutworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
100% to CYP4L10 of Huang
CYP4L11 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
86% to CYP4L5 Helicoverpa armigera 80% TO 4L3 Helicoverpa armigera
83% to 4L9v1, 80% to 4L10, 80% to 4L8
CYP4L11 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_158 3 aa diffs to CYP4L11 of Rene Feyereisen
HAH001562 100% to Contig_158
CYP4L12 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4L5, 80% to CYP4L9, 77% to 4L11, 76% to CYP4L13
89% to 4L4, 87% to 4L9, 78% to 4L8, 77% to 4L10
CYP4L13 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to CYP4L9, 76% to CYP4L12, 72% to 4L5, 69% to 4L11
86% to 4L7, 74% to 4L4, 89% to 4L9v1, 89% to 4L8,
88% to 4L10, 87% to 4L9v2
CYP4L14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_218 94% to Contig_173 CYP4L5
CYP4L15 Spodoptera exigua (beet armyworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
94% to CYP4L4, 97% to CYP4L16
CYP4L16 Spodoptera exigua (beet armyworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
93% to CYP4L4, 97% to CYP4L15
CYP4L17 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-12
49% to CYP4L4, 48% to CYP4L7,
probable ortholog of other CYP4Ls in moths
CYP4L18 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: CM4-2
58% to CYP4L4 Mamestra brassicae
55% to CYP4L7 Spodoptera exigua
CYP4L19 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
94% to CYP4L4 Mamestra brassicae, 97% to CYP4L15 Spodoptera litura
97% to CYP4L21, 97% to CYP4L20
CYP4L20 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
92% to CYP4L4, 95% to CYP4L15 Spodoptera litura, 97% TO CYP4L19,
97% to CYP4L21
CYP4L21 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
92% to CYP4L4, 96% to CYP4L15 Spodoptera litura,
97% TO CYP4L19, 97% TO CYP4L20
4M Subfamily
CYP4M1 Manduca sexta (tobacco hornworm)
GenEMBL L38670 (397bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4M1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4M2 Manduca sexta (tobacco hornworm)
GenEMBL L38671 (1512bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4M2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4M3 Manduca sexta (tobacco hornworm)
GenEMBL L38672 (397bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4M4v1 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86005
Pittendrigh,B., Aronstein,K., Zinkovsky,E., Andreev,O.,
Campbell,B., Daly,J., Trowell,S. and ffrench-Constant,R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
pyrethroid-susceptible and -resistant strain
Insect Biochem. Mol. Biol. 27 (6), 507-512 (1997)
hacyp63
CYP4M4v2 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL AF182171
99% to 4M6 in H. zea = ortholog
98% to 4M4v1 (2 aa diffs)
CYP4M4? Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
100% overlap with CYP4M4v2 (14aa) C-term frag. 70 aa
seq #16 HaCypZ019a-v1Pep
this seq may be the C-terminal of CYP4M4
CYP4M5 Bombyx mori (silkworm)
No accession number
Kyoko Kikuchi
54% to 4M2 71% to partial 4M1 sequence 74% to 4M4 partial seq.
submitted to nomenclature committee Jan. 16, 2001
CYP4M6 Helicoverpa zea (corn earworm)
GenEMBL AY113687
Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
submitted to nomenclature committee June 15, 2001
Clone name x32
501 aa 54% to 4M2
CYP4M6v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
98% (9 aa diffs) to CYP4M6 AY113687 Helicoverpa zea
(corn earworm) ortholog
CYP4M6v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH005656 97% to CYP4M6v1
CYP4M7 Helicoverpa zea (corn earworm)
GenEMBL AY113688
Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
submitted to nomenclature committee June 15, 2001
Clone name x39
502 aa 53% to 4M2 77% to 4M4 I-helix to heme
CYP4M7v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
99% 6 aa diffs to CYP4M7 AY113688 Helicoverpa zea
(corn earworm) ortholog
CYP4M7v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_194 97% to CYP4M7
HAH003557 100% to Contig_194
CYP4M8 Trichoplusia ni Family: Noctuidae (caterpillar)
No accession number
Ping Wang
54% to 4M2 70% to 4M1 I-helix to heme (sequence 2)
submitted to nomenclature committee 5/20/02
CYP4M9 Bombyx mori (silkworm)
BAAB01103156.1 BAAB01142776.1 BAAB01178932.1
57% to 4M5
See silkworm page for sequence
CYP4M10v1 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ020a-v1Pep
67% to 4M7
CYP4M10v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
1 aa diff to Heckels seq
CYP4M10v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH001186 has 4 aa diffs to CYP4M10v1
Contig_155 has 1 aa diff to HAH001186
Contig_225 2 aa diffs to Contig_155
CYP4M11 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee June 12, 2005
Clone name sequence 2
70% to CYP4M6 but only I-helix to heme fragment
CYP4M12v1 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A1
76% to CYP4S2
CYP4M12v2 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A11
2 aa diffs to CYP4M12v1
CYP4M13v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RT4 83% to 4M6,
98% or 2 aa diffs to CYP4M12v1 possible ortholog
CYP4M13v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SC4 97% to 4M13v1,
possible allele, 96% to 4M12v1, 81% to 4M6
CYP4M14v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name R35 79% to 4M6
CYP4M14v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SB2 99% (1 aa diff) to CYP4M14v1,
78% to 4M6, 89% to CYP4M15
CYP4M14 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4M15, 77% to 4M10, 69% to 4M6, 67% to 4M7,
65% to 4M17, 64% to 4M18, 69% to 4M6, 91% to 4M14v1
and v2, 89% to 4M15, 79% to 4M4v2, 75% to 4M13v1,
75% to 4M12v1, 61% to 4M16, 63% TO 4M11, 65% TO 4M8
possible ortholog of CYP4M14 Spodoptera litura (common cutworm)
CYP4M15 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name R31 89% to 4M14v2, 81% to 4M6
CYP4M15 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4M14, 79% to 4M10, 71% to 4M7, 70% to 4M6, 67% to 4M17,
66% to 4M18, 71% TO 4M7, 65% to 4M8, 62% to 4M16,
96% to 4M15 (5 aa diffs),
90% to 4M14v1, 76% to 4M13v1, 77% to 4M12v1, 68% to 4M11
possible ortholog of CYP4M15 Spodoptera litura (common cutworm)
CYP4M16 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SD1 65% to CYP4M14v1, 63% to 4M7
CYP4M17 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
74% to 4M7, 78% to 4M14v1, 73% to 4M13v1, 75% to 4M15,
73% to 4M12v1, 69% to 4M11, 65% to 4M16
CYP4M18 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 4M13v1 (6 aa diffs in 149aa), 96% to 4M12v1 (5 aa diffs in
149aa), 77% to 4M15, 73% to 4M14v1, 65% to 4M16, possible ortholog of
CYP4M12 or 4M13.
CYP4M19 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189047.1, GenPept ABW34434
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
5 aa diffs to 4M11 this might be a CYP4M11 allele
MFEGHDTTATGLVYLLMSLACDKMIQDKVVEELKEIFGDSTRPA
TMQDLGKMKYLDCCIKESLRLYPPVPFIARILNEEVVLSGYKVPAGTQCNIHIYDLHR
RADLFENPSKFDPDRFLPKNSAGRHPYAYIPFSAGPRNCIGQK
CYP4M20 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189048.1, GenPept ABW34435
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
75% to 4M15 Spodoptera litura
MFEGHDTTASGLVYFLMLLANHRDIQKKVTAELDSIFGSSDRPA
SMADLARMRYLDCCVKESLRLYPPVPFISRELQEPVVLSNYTIPSGMFVHIHIFDLHR
REDLFPDADRFDPDRFLPENSAGRHPYAYIPFSAGPRNCIGQK
CYP4M21 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189049.1, GenPept ABW34436
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
61% to 4M19 Plutella xylostella
MFEGHDTTARALCFLLMSIANEPIVQDTISSELQDIFQGSDRPP
TVEDLHEMKYLECCIREGLRLYPSVPYIARLLKEDTVLSGYVVPAGTIVNIHVFDVHR
RAELFPEPEAFRPERWLAPPPHKYAYVPFSAGPRNCIGQK
CYP4M22 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189050.1, GenPept ABW34437
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
65% to 4M19, 65% to 4M5
MFEGHDTTAMGLTFILMELANNPSVQDKVVQELREIFGQSARPG
SMQDMSQMKYLECCIKETLRLYPPVPFISRYITDTVTLSGHVIPRGKTLCHIHIFDLH
RRADLYPSPLVFNPEQFTAGNCASRHPYAYIPFSGGPRNCIGQK
CYP4M23 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189051.1, GenPept ABW34438
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
62% to 4M6 Helicoverpa zea
MFEGHDTTSTALQMIFMLLANNVDSQDKIVEECDRIFGSSDRSA
TMDDLTQMKYLECCIKEGLRLFPPVFFIQRMLTEPMKFREHEVPAGTDCTVFILDLHR
RADQFDEPHSFRPERFLAESPSWHPYSYIPFSAGPRNCIGQKI
CYP4M24 Ostrinia furnacalis (Asian corn borer)
No accession number
Zhang Yuliang
submitted to nomenclature committee Feb. 17, 2009
77% to CYP4M6, partial sequence
CYP4M25 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: CM4-1
59% to CYP4M7 Helicoverpa zea
CYP4M26 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
4N Subfamily
CYP4N1 Musca domestica
Rene Feyereisen
submitted to nomenclature committee
CYP4N2 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4N3X see CYP4D8
CYP4N4X see CYP4E4
CYP4O1 I and O not used in this nomenclature
4P Subfamily
Cyp4p1 Drosophila melanogaster
GenEMBL U34327(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4p1 Drosophila melanogaster
GenEMBL AC018129 comp(67703-69662)
ESTs AI405947 AI109737 AI293255
GSS AL063060 722-913
Cyp4p1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4p2 Drosophila melanogaster
GenEMBL AC018129 comp(70087-72192)
EST AI389883
GSS AL055774 comp(4-805) AL063060 28-294
Cyp4p2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4p3 Drosophila melanogaster
GenEMBL AC018129 comp(65426-67385)
No ESTs no GSSs
Cyp4p3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4P4 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4P
63% to 4P1 (140 aa)
4Q Subfamily
CYP4Q1 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S2
submitted to nomenclature committee
CYP4Q1 Tribolium castaneum (red flour beetle)
GenEMBL XP_971238
69% to CYP4Q2, 63% to 4Q7
MLLSTTLVCAIGLLGVFHLLAWIKFHASNYMKMCVIPGPPQKGILIGNMTYLQTTPEKIFLRLREATKNF
YPIYKLNALHKCAANILNPEDCELIMSNSAHNQKGQIYDLLRNWLKDGLLTSFGAKWQTRRKILTPAFHF
SILQQFVQIFNEEAEILVEDLKKDCSKSYISISSHITKFTLKTIAETAMGSKLKFETQKEIDYYQAVYDV
GKILLYRLTHPWFIFHYVNFFSPWYLQEVKVTKTLHNFTREVIKHREENFKDIELPTEEHEVYKGKKRLA
MLDLLLSAKHKEGIVENDGIQEEVDTFMFKGHDTTSAALCFALMLIASHSEVQESIVAEMREVLGDLSKK
PSYNDLQNLKYLERCIKETLRLYPSVHFISRTLGQDLITTGGYTLPKESNAIIHIYDVHHNADIYPDPEK
FDPDRFLPENVQKRHPYAYLPFSAGPRNCIGQRFAMLELKTAICAILANFTLQPIDTPETIILVVDIILR
TKEPIKIKFVPRS
CYP4Q2 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S35
submitted to nomenclature committee
CYP4Q2 Tribolium castaneum (red flour beetle)
GenEMBL XP_971175
69% to CYP4Q1
MFASTLILTTIFAIVSVLAFKRIKYHVKNYILLNKLPGPPPDGLFVGNMPYLQTTPEDIFNRLREANKKF
YPIYKLFAVHRMGANILSPEDSEIVLSNPIHNEKGYIYKLLHHWLKEGLLTSKGEKWQLRRKILTPAFHF
NILQQFIMILNEEAEKLVEGLRKECHKPYINITPHISQFTLKSITETAMGTKLDFTTKKEIRYKEAVYKI
GKILTYRITHPWFIEPLLNIFSPCFIQERRVTSTLHKFTKEVIEDREKNFKDFELPTEEHDVYKGKKRLA
MLDLLLSAKKKDGIIDNKGIQEEVDTFMFEGHDTTAVALNFALMLIACHKDVQETILQEMRDVLGDIHAK
PTYSDLQNLKYLERCIKESLRLYPSVHLISRALGEDVRTQKGYLIPKDTITIIHIYDLHHNPDIYPDPEK
FDPDRFLPENCQNRHPFAYLPFSAGPRNCIGQRFAMLELKAAICAILANFVLEPIDTPETIVVVVDIVLR
TKEGIKIRFVPREQ
CYP4Q3 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R15
submitted to nomenclature committee
CYP4Q3 Tribolium castaneum (red flour beetle)
GenEMBL XP_971112
66% to 4Q7
MLLSSSVLFVISFFLVLYFFKKLKCVSAKLYNLGKLDGPSNHNIIIGNVLRLH
AAPEVIFKKLRQWARDYYPVYQLRAIHIPAACILAPEDFEAILSNPRHIEKSMVYLLLHDWLGTGLLTSG
GQKWATRRKILTPAFHFSILQQFITIFNEETDKLVDTFKQQCDQPIEITSHITQFTLKTIGETAMGTKFE
FTTRKQIEYKQAILEIGEILLYRLLNSWLISDYLNFFSPHRLREKRLVKTLHTFTRDVITEREKTFEKFQ
LPTEEHDVYIGKKRLAMLDLLLTAKNEERTIDEDGIREEVDTFMFEGHDTTSAALSFALMLLANHKNVQD
QIVDEMVTVLGDLHQKPTYNNLQEMKYLERAIKESLRLYPSVHFISRKLGEDFVTCNGLKLPKSTITHLH
IYDLHHNPDIYPDPEKFDPERFRPENSQKRHPFAYLPFSAGPRNCIGQKFAMLELKAAICGILANFILEP
VDTPESIVLVVDLVLRTKNGIKIGFIPRVK
CYP4Q4 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S1
submitted to nomenclature committee
CYP4Q4 Tribolium castaneum (red flour beetle)
GenEMBL AAP94193, 98% to AF251548_1 (7 aa diffs)
57% to 4Q5
MFLAPIILCLVLLALLVSSLRKKGRFWECLAPIPQPPAYPIIGNLFDIMRTPEQMFLADRERGLKYYPIY
KLDVCGTGGVNLLNPEDVELVLTDTKQNTKSFIYHFLHSWLGTGLLTSRGPKWQNRRKILTPAFHFNILQ
EFIQIFNEETKRLVEDLEAESHKPYIDVVVPITQFTLLSIGETAMGIKLNASDNDKDGYKRAVYKIGQLL
TYRAPRPWIHNETIYSLTPQGRKEQKVLKSLHSFSNNVIAERKKHFSSSSYSSRKRLAMLDLLLKYKSEG
ANIDDEGIREEVDTFMFEGHDTTSVSICYTLMLLANHREVQEEILKEMEAVLDEEPPTYAKLQELKFMDR
VIKESLRLYPSVPFISRVSGSEIQTKTGYTIPKDCMVNLQIYDMHHNPNVFPDPEKFDPDRFLPENIQKR
HPFAYIPFSAGSRNCIGQKFAMLEIKTVLCGILKKFILEAVDTRKDMAFVSDLVLRPKGSIKVKFVPRRAN
CYP4Q5 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S58
submitted to nomenclature committee
CYP4Q5 Tribolium castaneum (red flour beetle)
GenEMBL XP_971423
57% to 4Q4
MIQSTLLLIFIVILSVIIYIWWYQNFSRFFSLLNKVPGPPGYPIIGNIIQFLATPEELFKIDRELGRRFY
PIYKEWTLTYGAVNLLHPDDIELVLSNSKYNDKSAIYDFLHCWLGTGLLTSSGTKWQTRRKVLTPAFHFN
ILQQFLPIFNEETVKLIKNIKNDQPIDVIPPVTQFTLLSIAETSMGVKLDASPKSCDDYKNAIHVFGYAL
TYRLGRPWLHNPFVFFNLTRLGHLTKKSIKILHDFSRNVIEQKKRTFEGEKRGKRLAMLDLLLLAKHQGA
DIDDEGIAEEVDTFMFEGHDTTSIAICYTLLLLANHPDIQDELYSELKSVLSDPTQTPSYSDLKQLNLME
RCIKESLRIFPSVPFISRLLTEDLTTASGYVIPRGSMAHIHIYDLHNNPEIYPDPKKFDPDRFLPENCQK
RHPFAYLPFSAGPRNCIGQKFAMLELKVVLSGILGNFVLEAVDKPKDVTMITDLVLRCKGPIRVKFVPRYKIN
CYP4Q6 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R4
submitted to nomenclature committee
CYP4Q6 Tribolium castaneum (red flour beetle)
GenEMBL XP_970404, AAJJ01002630.1
54% to 4Q4
MLSFYLLLTGVGLILLLQTWRFFRKYFKNKTILKKIRGPPETPIFGHMYIFTQDP (1)
DLLFSRIRKYSREYYPIFRFSALYVDIVNFLEPNDIELILSTTKHLSKSKIYTFLNNWLGTG
LLTSTGAKWHQRRKILTPAFHFNILQQFLNIFNDETEKLVLRLGEDCGRTIDVVPPVTNFTLQSIAETAM
GLSNINELTQKEYKKAIYKIGHIFLKRLSKPWYRLDAIYNYSKLAEEENATVKILHDFSNGIISEREKER
TTNLSQNLASYSKKKRMAMLDLLLAAKNEGADIDYEGIREEVDTFMFEGHDTTSMAISFILLTLANLQDV
QTKVREEILSVVGKEKIPTYNDLQELKYTERCIKETLRLFPSVPFISRYASEDFVTKTGYTIPEGTVLHI
HIFDLHRNAEIYPDPLKFDPDRFLPEKVNERHPFAYIPFSAGPRNCIGQKFAFLELKTVLCGILRKFKLE
KVDDMYEIEFRPDLVLRPKNDVKVRIEKL
CYP4Q7 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
formerly CYP4R1 (sequence revised 1/29/99)
submitted to nomenclature committee
CYP4Q7 Tribolium castaneum (red flour beetle)
GenEMBL AF254755_1
66% to 4Q3
MLVLTTVLTAAAVFLLFYLFYCYKTIKQHIYSLISLSYLPGPPVNDIISGNILPLYTSAENIFKQLREWG
RLYYPIYKLNAAHLAAANILSPEDCELVLSNPTHMEKSAIYNLLHDWLGTGLLTSTGLKWQTRRKILTPA
FHFSILQQFVAIFNEETDKLVEVLKEECYKPFINVNAHVAQFTLKTIAETAMGTKLRFTTRKETIYKQSI
VDMGEFLLYRLLRCWLISKCIYVFNPRYYLEKKVTRRLHRFTKSVIAERQENFKEIVVPETDEVYTGKRR
LAMLDLLLTAKNKEGLIDDEGIREEVDTFMFEGHDTTAAALGFALMVLAGHKEVQDKIVEEMNEVLGDIK
KKPTYQDLQEMKYLERCVKEVLRLYPSVHFISRKLGEDLVTHSGHKLAKGSIVNLHIYDLHHNPAIYPDP
EKFDPDRFLPENCQKRHPFAYLPFSAGPRNCIGKKFAMLELKAAICGILANFTLEPIDIPETIVLVVDIV
LRTKEGIKVRFIPRV
CYP4Q8 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R22
submitted to nomenclature committee 1/29/99
CYP4Q8 Tribolium castaneum (red flour beetle)
GenEMBL XP_970987
68% to 4Q7
this seq is short
AAJJ01001877.1 N-term only runs off this contig
AAJJ01002307.1 C-term part, missing ETAM exon
MVLENIIIGLAAATAICYLFKQLIEMALVIFFVQKMPGPRKFNLFYGNMRPLHSSPAEIFNVLRKWGLEY
YPIYKLWLFFVSVANIMSPEDLALILPDMKHSKKSIAYDLIHRWLGSGLLTSYGTHWQVRRKILTPAFHF
SILQDFILTFNESTEELVELLKKEVEKPFVEITPLITXXXXXXXX
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
PKFYEERKLIKLLHNFTNDIIAKRRKDFHQGIVASQ
KKKRLAMLDLLLTVQKEEGIIDDEGIREEVDTFMFEGHDTVSSAINFALMVLANHPTVQEEIVQEMKDVL
GDTKKKPVYNDLQELKYMERVIKEVLRLYPSVHYISRELGEDMVTTTGYKLRKGTILQLHIYDLHYNPVI
YPEPEKFDPDRFLPENCDKRHPYAYIPFSAGPRNCIGQRFAMLELKAVLCGILSNFTLQPVDTPESIVMV
EDIVLRTKENIKVKFVPREM
CYP4Q9 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S25
submitted to nomenclature committee 1/29/99
CYP4Q9P Tribolium castaneum (red flour beetle)
GenEMBL AF265297_2, AAJJ01002307.1, 6 P450s on this contig
66% to 4Q7
Some frameshifts and a bad boundary, probable pseudogene
MIILLIIVALVLALFLKPLGHYISIIKYVQQLPGPPCENFLHGNITHLYGPP (1)
EKMFKTVRKWGLEYYPIYQNWIAHVAVANVMNPYDFEV (1?)
ILSNMKH TSKSMIYDMLHCWLGTGLLTSDGIKWQTRRKILTPAFHFNILQEFIKIFNEETETLVQQL
KKHSNSSVDVTEYISAFTLNTIG (1)
ETAMGTSFGTETSTGREYKKSIQEIGEILKYKLLRPWLLSKFVYVCDPNYWKEIKLVKIL
HNFTNNVIANRQSNFKPVEQKSDEFSYSRRKRMAMLDLLLTAKNEDNLIDDEGIREEVD
TFMFEGHDT
2269 TAVAICFALMCIACHPDIQ (0)
ERIFEEIEETFSDDTKPDYKSLQELKYMERCIKEVLRLYPSVPFIARSLGE
DIVTYSGHKLKAGSMVHLHIYDMHHNPQVYPDPEKFDPDRFLPENCLKRHNFAYVFP 2694
SAGPRNCIGQKFAILEMKAVLVGILKEFTLEPVD
VDTPETLVMKTDLVLRAMNGVRVKFVPRICAK*
CYP4Q10 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4Q53c63
64 amino acids from heme to end
49% to 4C3, 51% to 4C25, 66% to CYP4Q3 = XP_971112,
67% to 4Q11
CYP4Q11 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G758106
64 amino acids from heme to end
53% to 4J9, 52% to 4C3, 68% to CYP4Q8 = XP_970987
4R Subfamily
CYP4R1X Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S11
submitted to nomenclature committee
sequence revised now it is CYP4Q7
4S Subfamily
CYP4S1 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp59a
submitted to nomenclature committee
CYP4S1v2 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ021a-v2Pep
73% to 4S4 95% to 4S1 only 4 aa diffs not on the extreme ends
of the original 4S1 PCR fragment. Probably the same gene.
CYP4S2 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp58
submitted to nomenclature committee
Cyp4s3 Drosophila melanogaster
GenEMBL AC018488 comp(98620-101060) also AC015418 AC018487
Cyp4s3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4S4 Mamestra brassicae (moth)
GenEMBL AY063500
Martine Maibeche
86% to 4S1 (partial seq)
clone name MbraB1 full length
submitted to nomenclature committee Oct. 5 2001
CYP4S5 Bombyx mori (silkworm)
BAAB01177041.1 BAAB01181662.1 BAAB01048279.1 BAAB01025317.1
64% to CYP4S4
See silkworm page for sequence
CYP4S6 Bombyx mori (silkworm)
BAAB01121123.1 BAAB01054179.1 BAAB01073078.1 BAAB01008096.1
BAAB01081659.1
94% to 4S5
See silkworm page for sequence
CYP4S7 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4S
71% to 4S3 (266 aa)
CYP4S8v1 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A2
76% to 4S2
CYP4S8v2 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A6
1 aa diff to CYP4S8v1
CYP4S8v3 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A9
1 aa diff to CYP4S8v1
CYP4S8v4 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SB1 84% to 4S2, identical to 4S8v1
except for a short frameshifted region.
The CYP4S8v1 sequence is probably wrong in this region.
CYP4S9v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RTH17 78% to 4S4, 97% to 4S9v2
CYP4S9v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SA4 78% to 4S4, 97% to 4S9v1
CYP4S10v1 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee Dec. 10, 2005
Clone name Sequence 4 NB5 fragment (C-terminal)
76% to 4S9v2 73% to 4S4
CYP4S10v2 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189052.1, GenPept ABW34439
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
1 aa diff to 4S10v1, 75% to 4S9v1
CYP4S11 Spodoptera exigua Hubner (beet armyworm)
No accession number
Mo Jianchu
Submitted to nomenclature committee Oct. 30, 2006
95% to 4S8v4
146 aa fragment
CYP4S12 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_149 59% to CYP4S5, 44% to CYP4M7
HAH002398 has 1 aa diff to Contig_149
CYP4S13 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH006401 67% TO CYP4S5, 45% to CYP4M15, 45% to CYP4J9
CYP4S14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_232 64% to CYP4S13
HAH001808 100% to Contig_232 95% TO CYP4S12 N-term,
56% TO CYP4S5, 54% TO CYP4AX1, 42% to CYP4M10
CYP4S15 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
4T Subfamily
CYP4T1 Oncorhynchus mykiss (rainbow trout)
GenEMBL U82983
Patrick Falckh
closest resemblance to CYP4B
CYP4T2 Dicentrarchus labrax (European sea bass)
GenBank AF045468
Sabourault,C., Berge,J., Lafaurie,M., Girard,J.P. and Amichot,M.
Molecular cloning of a phthalate-inducible CYP4 gene (CYP4T2) in
kidney from the sea bass, Dicentrarchus labrax.
Biochem. Biophys. Res. Commun. 251, 213-219 (1998)
69% identical to 4T1 fragment
authors name CYP4DL1
CYP4T3 Xenopus laevis
GenEMBL AB022671
Satoru Yamamoto
Clone XL-304
58% identical to CYP4T2 62% to 4T1
submitted to nomenclature committee Oct 19, 1999
MWNALVWQQVAALLCLLAVLLKATQIYLSKKRQERILEQFPGPP
RHWLLGNVDQIRRDGKDLDLLVNWTQSHGGAYPVWFGNFSSFLFLTHPDYAKVIFGRE
EPKRQLSYNFLVPWIGNGLLVLTGPKWFQHRRLLTPGFHYDVLKPYVKLISKCTTDML
DNWEKLITKQKTVELFQHVSLMTLDSIMKCAFSYESNCQKDSDNAYIKAVFDLSYLAN
LRLRCFPYHNDTIFYLSPPWVSISPSLQNNSEHTDKVIQQRKESMKHEKELEKIQQKR
HLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQTMEWKDLGKIPYTNMCIKESLRIYPPVPGVARMLRNPVTFFDGR
SIPAGTLVGLSIYAIHKNPAVWEDPEVFNPLRFTPENSANRHSHAFVPFAAGPRNCIG
QNFAMNEMKIAVALTLNRFHLAADLENPPILIPQLVLKSKNGIHVHLNKVQ
CYP4T3v2 Xenopus laevis
No accession number
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
99% to 4T3 1 aa diff (PCR from I-helix to heme)
CYP4T4 Xenopus laevis
GenEMBL AB022672
Satoru Yamamoto
Clone XL-301
70% identical to CYP4T3
submitted to nomenclature committee Oct 19, 1999
KQCAGLFCVFASHSNLCIAYEMQKPLIVTQILAGKGLLVLSGDK
WFQHRKLLTPGFHYDVLKPYVRLISDSTNVMLDKWVSFSNKGETVELFHHVSLMTLDS
IMKCAFSFHSNCQTDKDNSYTKAVYDLSFLAHHRARTFPYHNNLIYYLSPHGFLFRKA
CRIAHQHTGKVIKQRKTLLQNKGEFEKVKQKRHPDFLDILLCARDENGKGLSDEDLRA
EVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIREVLGEKDSYEWEHLSKIPY
TTMCIKESLRLYPPVPGVSRELNKPITFYDGRSLPAGSVIFINIFCIHRNPSVWKVPE
VFDPLRFSSENSSKRHSHAFVPFAAGPRNCIGQNFAMNELKVAVALTLNRYELSPDLS
KPPLKSPQLVLRSKNGIHVYLKKAS
CYP4T5 Fugu rubripes (pufferfish)
No accession number
Scaffold_8637
78% to 4T2
508 MEITRALVVLGWSHFYQLLALFCLAIVLYKLTVLLMLKRALIRNFESFPGPPGHWLFGNILE 693 (0)
902 FKQDGNDLDKLVKFGQKYPYCFPLWFGPFVCFLNIHHPEYVKTILAST 1045 (1)
1142 EPKDDLAYSFIQNWI 1186 (1)
1291 GNGLLVSQGQKWFRHRRLLTPGFHYDVLKPYVKLMAHSTKTML 1419 (0)
1673 DKWESYAKTNKPLEVFEYVSLMTLDTILNCAFSYDSNCQTER 1798 (2)
2267 KNTYIKAVYELSNLINLRFRIFPYHNDLIFYLSPHGFRYRKACMVAHSHT 2416 (1)
2521 EEVIKKRREALKKEKELERIQAKRNLDFLDILLFAK 2638 (0)
3171 DENQQGLLDEDIRAEVDTFMFEGHDTTASGISFLLYNLACHPKHQKLCRKEIMQVLHGKDTMDW 3362 (2)
3457 EDLNKIPYTTMCIKESLRMHPPVPGISRKTTKPITFFDGRTLPA 3588 (1)
392 ESRIGTSVFGIHRNASLWENPNV 457 (1) this exon from Fugu LPC.11421.x1
fdhwrflpenvskrsphafvpfsagpr this exon from 4T2 Dicentrarchus labrax
NCIGQNFAMNEMKVVIAMTLLKYELLEEPTLKPKIIPRLVLRSLNGIHIKIKNANQN*
CYP4T6 Xenopus laevis
AB114056
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
Second of three sequences submitted
76% to 4T3, 77% to 4T4, 72% TO 4T7 (PCR from I-helix to heme)
94% to CYP4T10 Xenopus tropicalis, possible ortholog
TSSGISWILYCMATHPEHQQKCQEEINEVLGERQTMEWDDLGRI
PYTTMCIKESLRLYPPVPSVSRELAKPITFHDGKSLPAGILVSLQIYAIHRNPNVWKD
PEIFDPLRFSPENSSKRHSHAFVPFA
CYP4T7 Xenopus laevis
AB114057
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
Third of three sequences submitted
74% to 4T3, 71% to 4T4, 72% to 4T6 (PCR from I-helix to heme)
TASGISWILYCMAKYPEHQKKCREEIRELLGDRETMEWGDLGQM
PYTTLCIKESIRLYPPVPTIGRRLSKPITFCDGRSLPEGTEVLTSIYAINRSPSVWND
PEVFDPLRFSPENSDNRHSHAFVPFS
CYP4T8 Danio rerio (zebrafish)
BC056734, NM_199216, CF943677
AI959112 fd24f08.y1 AI558878 fb67e05.y1
64% to 4T5 fugu
MLLYGISPFVLSVNHVFALIFLACLLTVVKLLIVRRKGVKTMER
FPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQFAFPLWFGPSLAVLNIHHPSYAKT
ILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDS
TKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFD
LCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQG
IVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLAC
NPEHQEKCRQEIQQALDGKDTLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPL
TFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENAANRSPHAFVPFSAG
PRFVTRSV
CYP4T9 Xenopus tropicalis
DR860523.1 CX967683.1 DT412234.1 DR834559.1
Called CYP4T8 on Xenopus pages
89% to CYP4T4 of Xenopus laevis
best match in human = 4B1 55%, possibly a 4B1 ortholog
MWNTLVWQQVA
ALLCLLAVLLKATQLYLSQKRQENIFKQFPGPPRHWLLGNVDQIRRDGKDLDLLVNWTHK
NGGAFPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSISYDFLVPWIGKGLLVLTGPKWFQ
HRRLLTPGFHYDVLKPYVNLISKCTTDMLDNWEKLITKQKTVELFQHLSLMTLDSIMKCA
FSYDSNCQKDSNNAYIKAVFDLS
YVANLRLRCFPYHNDTVFYLSPHGYRFRKACRITHEHTDKVIQQRKESMKLEKELEKIQQ
KRHLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQIMEWEDLGKIPYTNMCIKESLRMYPPVPGVARQLRNPVTFFDGRSV
PAGTVIGLSIYAIHKNPAVWEDPEVFNPLRFSPENSANRHSHAFLPFAAGPRNCIGQNFA
MNEMKVAVALTLNRFHLAPDLENPPIRIPQLVLKSKNGIHVHLTKVQ*
CYP4T10 Xenopus tropicalis
NM_001017348.2 from refseq database
Called CYP4T9 on Xenopus pages
55% to 4B1 human, 73% to DR860523.1
79% to CYP4T3 of Xenopus laevis
MASTLWKALSSPWLSVNIYQIGQFVALLCVVLLLLKAYALYSRG
RRFAAALVPFPGPPAHWLYGHVNQFRRDGKDLDRLMVWVNKYPNAFPLWIGKFFGTLI
ITDPDYAKVVFGRSDPKTSTGYNFLVPWIGKGLLILSGNTWFQHRRLITPGFHYDVLK
PYVSLISDSTKIMLDELDVYSNKDESVELFQHVSLMTLDSIMKCAFSYHSNCQTDKDN
DYIQAVYDLSWLTQQRIRTFPYHSNLIYFLSPHGFRFRKACRIVHLHTDKVIGQRKKL
LESKEELEKVQKKRHLDFLDILLCSKDENGQGLSHEDLRAEVDTFMFEGHDTTSSGIS
WILYCMATHPEHQQKCREEISEALGERQTMEWDDLNRMPYTTMCIKESLRLYPPVPSV
SRELAKPITFHDGRSLPAGMLVSLQIYAIHRNPNVWKDPEIFDPLRFSPENSSKRHSH
AFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELSPDLSKPPLKQPQLVLRSKNGIH
VYLKKAS
CYP4T11 Gobiocypris rarus (a rare minnow)
GenEMBL EU593896 (not available yet on May 16, 2008)
Jiayin Dai
Submitted to nomenclature committee 4/2/2008
87% to zebrafish CYP4T8
MQLYEIFPLNLEALSINHAFPLALLVCLVIVDRLMTMKRRGMRTMEPFPGPPAHWLFGHVKEFHQDGHDLEKIIMWCEQYPFAFPLWFGPSLSILNIHHPSYVKTILTTTEPKDDYAYKFFIPWLGDGLLVSAGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWELYAKSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYKFRKAAGMAHNHTAEVIRKRKEVLKMEKEQGIVKNKRYLDFLDILLSARDENQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCREEILRALDGKDTLEWEDLNKIPYTTMCIKESLRLCPPVPGISRKLTKPLTFFDGRTVPEGCTIGVSIYGIHLNATVWENPYVFDPLRFLPENTAKRSPHAFVPFSAGPRKGKFFKELFPVQS
CYP4T12 medaka
UCSC Browser chr16:19969746-19976887 (+) strand, Oct. 2005 assembly
68% to 4T1 zebrafish, 52% to CYP4B1 human,
51% to CYP4A11
MFAAGLTEALFG
FQLTWLHIHVAFGALCIIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
LAQDGTDLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDLAYRFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
DKWESYANTSETFELFEHVSLMTLDSILKCAFSHNSNCQREG (2)
ETNKYIKAVYELSDLISFRMRTFPYHSDLIFYLSPHGFRHRRACKVAHSHT (1)
QVIRKRKEALKEETESSRKRNLDFLDILLFAK (0)
DENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYCLASHPEHQKICRNEVMEA
LDGKDTIEW (2)
EDLNKIPYTTMCIKESLRLYPPVPGISRKLTKPITFFDGRTLPA (1)
GFKVGTSVFGIHRNATVWENPE (0)
VFDPLRFLPENVSKRSPHAFVPFSAGAR (2)
NCIGQNFAMNEMKVVIAMTLKKYQLIEEPSLKPRIIPRLVLRSLNGIHIKIKPVEAQK*
CYP4T13P medaka
UCSC Browser chr16:19947384-19950469 (+) strand, Oct. 2005 assembly
missing some parts, 95% to CYP4T12 medaka, upstream by 19 kb
MFAAGLTEALFG
FQLTWLHIHVAFGALCLIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
PTQDTTNLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDFGYMFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
(missing 5 exons)
GFKVRTSVFGIHRNATVWENPE (0)
FDPLRFLPENVSKRSPHAFVPFSAGAR (2)
(seq gap)
CYP4T14 Lancelet (Branchiostoma floridae)
UCSC Browser chrUn: 340141881-340149534 March 2006 assembly
55% to 4T1 zebrafish, 54% to 4T12 medaka
gene order: KIF2A CYP4T14 PTCH1 MKNK1
MTPFMNFCLLILSTTTMGSIPAQWLPHWEA
GYLRTACLTVLVAVAVQLVFRFLRALLWKRYIQKVLAPFPGQPAHWLFGHMRE (0)
VRPDETGFTIVPQWAAKFKFAFPLWIGPFRVVLSLVHPDYIKEINSP (1)
VNDLHTILSIFFTEPKDRVSYAWLKPWI (1)
GDGLLVSEGQKWFRNRRLLTPGFHFDVLKPYVKVFSECTNIML (0)
DRWADLAPGTPVEMFHYASAMTLDSLMRCALSVRSDCQRDSDGSPYIRA
VYDLTKC
VVERGRFPPFHIPLIFHLSPTGFR ()
FRKACKTAHDFSDEVIRKRRTELQQQGCHQNDTANSSE
DGGKKRYLDFLDILLQAR (2)
DEDGKGLSEREIRDEVDTFMFEGHDTTASGVSWILY
NLAKHPACQDRCRAEVDAVLQGRAEVKW (2)
EDLSKLPYTTMCIKESLRMHSPVPGVTRLTTQPHTFPDGRSIPA (1)
GVSVSIGVHSLHHNIHVWGDN (0)
EFDPERFSPENSKGRSSHAFIPFSAGSR (2)
NCIGQHFAMNELKVTVALTLQRYRLELDETRPPYR
VARLITRTRDGLWLKVYPRGADN*
4U Subfamily
CYP4U1 Coptotermes acinaciformis (termite)
GenEMBL AF046010
Patrick Falckh
C4-8_9-D
CYP4U2 Coptotermes acinaciformis (termite)
GenEMBL AF046011
Patrick Falckh
C4-8_9-F
CYP4U3 Reticulitermes flavipes (termite)
No accession number
Michael Scharf
Submitted to nomenclature committee Feb. 19, 2009
Clone name RfP4501V1 (full length)
99% to CYP4U3v1 (only 1 aa diff)
98% to 4U3v2 (only 2 aa diffs)
52% to CYP4U1 Coptotermes acinaciformis (termite),
69% to CYP4U2 partial seq
47% to CYP4BN6 Tribolium
CYP4U3v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #1v1
67% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v2
CYP4U3v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #1v2
68% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v1
CYP4U4P Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #8 (pseudogene)
78% to 4U1 I-helix to heme, one stop, 2 frameshifts
4V Subfamily
CYP4V1 Oncorhynchus mykiss (rainbow trout)
GenEMBL AF046012
Patrick Falckh
OM4-8_9
CYP4V2 human
GenEMBL AC012525
formerly CYP4AH1 AC012525 Homo sapiens chromosome 4
MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGR
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEG
ILTSSKQIDKSSMYKFLEPWLGLGLLT
STGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIIC
ETAMGKNIGAQSNDDSEYVRAVYR
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSV
IAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE
GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV
KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSED
YFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQG
RHPYAYVPFSAGPRNCIG
QKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER*
CYP4V2 Macaca mulatta (rhesus monkey)
95% to human 4V2
MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV
GHALLMKRDGR (1)
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE (0)
VILTSSKQIDKSSMYKFLEPWLGLGLLTS (2)
TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHVNQEAFNCFVYITLCALDIIC (1)
ETAMGKNIGAQSNDDSEYVRAVYR (2)
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHAFTNN (0)
VIAERANEMNVDEDCRGDGRDSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE (0)
GHDTTAAAMNWSLYLLGSNPEVQKKVDHELDDVF (1)
GRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV (1)
AGYRVLKGTEAV
IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCI (1)
GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 1551
CYP4V2 Bos taurus (cow)
See cattle page for details
MLAPWLLSVGPKLLLWSGLC
AVSLAGATLTLNLLKMVASYARKWRQMRPVPTIGDPYPLVGHALMMKSDARDFFQQIIDFTEECR
HLPLLKLWLGPVPLVALYNAETVEVILSSSKHIEKSYMYKFLEPWLGLGLLTSTGNKW
RSRRKMLTPTFHFTILEDFLDV
MNEQANILVTKLEKHVNQEAFNCFFYVTLCTLDIICETAMGKNIGAQRNDDSEYVRAVYR
MSDSIHQRMKMPWLWLDLIFYMFKNGREHRRSLKIVHDFTNNVITERANEMKRHEEGTSN
DKEKDFPPRKTKCRAFLDLLLNVT
DDQGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGWYPEVQQKVDTELEEVFGKS
DRPVTLEDLKKLKYLDCVIKESLRLFPSVPFFARNLTEDCEVAGHKMVQGCQVIIVPYAL
GSSRDPKYFPDPE
EFKPERVFPENLKGRHTYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKRE
ELGLAGELILRPSNGIWIKLKRRNTDES*
CYP4V2 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
Two partial sequences called CYP4V2_1 and CYP4V2_2
Are different parts of the same gene
Ortholog of human CYP4V2
CYP4V2 Sus scrofa (pig)
CB473254.1, DB791600.1
lower case = cow seq
mlapwllsvgpklllwsglc
avslagatltlnllkmvasyarkwrqmrpvptigdpyplvghalmmksdardffqqiidfteecr
hlpllklwlgpvplvalynaetvevilssskhieksymyk FLEPWLGLGLLTST
1 GNKWRSRRKMLTPTFHFTILEDFLDVMNEQATILVTKLEKHVNQEAFNCFF 153
153 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRVSDSIHRRMKAPWLWFDFLYFMFK 329
330 DGQEYRKSLKILHNFTSNVITERASEMKRDEERSHDDKDIPPHKNKCKAFLDLLLNVTDD 509
510 KGNKLSHEDIREEVDTFMFE 557
ghdttaaainwslyllg
FYPEVQKKVDNELDEVFGKSDRPATLEDLKKLKYLECVIKESLRLFPS
3 VPFFARSINEDCEIAGHKIVKDSQVIIVPYALHRDPRYFPNPEEFRPERFFPENSKGRH 179
180 SYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKREELGLAGEPILRPTNG 356
IWIKLKRRNTDES*
CYP4V3 mouse
No accession number
Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
Submitted to nomenclature committee July 5, 2000
Clone name KK-1
80% identical to 4V2 human
Cyp4v3 mouse
GenEMBL AB056457 28 feb 2001 81% to 4v2
MLWLWLGLSGQKLLLWGAASAVSLAGATILISIFPMLVSYARKW
QQMRSIPSVARAYPLVGHALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVAL
YKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILE
NFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNNDSE
YVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERVKER
KAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTT
AAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF
PSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQ
GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILR
PNNGIWIKLKRRHEDDP
CYP4V4 Xenopus laevis (African clawed frog)
No accession number
Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
Submitted to nomenclature committee July 5, 2000
Clone name XL-4
58% identical to 4V2 human
CYP4V5 Fugu rubripes (pufferfish)
No accession number
Scaffold_485
60% to 4V3 over 513 aa
exon 5 starts with ETAM seen in many Drosophila 4 fam. and C. elegans sequences
36037 MADLLGGFTLPLLGASVFVAALTCFTYRMLSDYLHKWFQMKPIPELEGTYPLIGNALQFKPNAG 36222 (1)
36309 DFFNQIVEYTRENYHRPLFKIWVGPVPFVVLFHPETVE (0)
36504 PVLTNAVHMEKSYSYSFLHPWLGTGLLT 36587 (2)
37012 STGPKWRRRRKMLTPTFHFSILADFLEVMNEQAEILVEKLDQQAGKGPFNCFSYVTLCALDIIC 37203 (1)
ETAMGKKIYAQSNSESEYVKCVSK 37380 (2)
37458 MSDIISRRQRTPWFWPNFAYYSIGDGREHDSTLKVLHSFTYK (0)
37661 VITERAENVSSVESDSDSDHGRKKRQAFLDMLLKTTDEDGNKMSHRDIQEEVDTFMFR (0)
37906 GHDTTAASMNWVLHLMGSHPEAQSKVHQELQEVF (1)
38199 GESNRPITTEDLKKLKYLESVIKEALRLFPSVPFFARSLGEDCHI 38321 (1)
38530 NGFKVPKGANAVIITYALHRDPRYFPEPEEFRPERFLPENSVGRPPYAYLPFSAGLRNCI 38724 (1)
38802 GQRFALIEEKVVLASILRKFNVEACQKREELRPVGELILRPEKGIWIKLEKRKPLIPPS* 38981
CYP4V6 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
82% to CYP4V ortholog of cow and 76% to 4V2 human
CYP4V7 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V7-ie6b Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V8 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V9 Xenopus tropicalis
See Xenopus pages for seq
CYP4V10v1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-1v1
CYP4V10v2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-1v2
CYP4V11 Orconectes limosus (crayfish)
GenEMBL AF091117
Chantal Dauphin-Villemant
submitted to nomenclature committee
this is a tentative assignment, this sequence may require its own
subfamily
50% identical to 4C1 over full length, 58% identical over C-terminal
formerly CYP4C15
CYP4V12 Penaeus setiferus (shrimp)
GenEMBL AF072854
Mark Snyder
submitted to nomenclature committee
formerly CYP4C16
CYP4V13 Haliotis rufescens (red abalone)
GenEMBL AF072853
Mark Snyder
submitted to nomenclature committee
formerly CYP4C17
CYP4V14 Homarus americanus (lobster)
GenEMBL AF072852
Mark Snyder
submitted to nomenclature committee
formerly CYP4C18
CYP4V15 Cherax quadricarinatus (crayfish)
No accession number
Moshe Tom
Submitted to nomenclature committee May 4, 2000
Clusters with the other crayfish sequence 4C24 on trees
formerly CYP4C29
CYP4V16 Carcinus maenas (shore crab)
GenEMBL AY328467
Kim Rewitz
submitted to nomenclature committee 6/18/2003
59.5% to 4C15
formerly CYP4C39
CYP4V17 Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia,
49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
Clone name Lv03
formerly CYP4C54
4W Subfamily
CYP4W1 Boophilus microplus (cattle tick)
no accession number
Crampton AL, Baxter GD, Barker SC
Identification and characterisation of a cytochrome P450 gene and
processed pseudogene from an arachnid: the cattle tick, Boophilus
microplus.
Insect Biochem Mol Biol 29, 377-84 1999
4X Subfamily
CYP4X1 human
GenEMBL BC028102
David Bell
submitted to nomenclature committee 12/30/97 revised 4/12/00
about 50% identical to CYP4A members
R56515, R53456, AA652746, AC026935
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQK
FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP
LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE
VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK
LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDES
GSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT
WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP
AVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV
TPDPTRPLTFPNHFILKPKNGMYLHLKKL
CYP4X1 Bos taurus (cow)
See cattle page for details
24776 MESSWLETHWARPFYLTLVFCLALGLLQAIKLYLQRQRLLRDLRLFPSPPTHWLYGHSK 24600
4386 LFKDGKMEILEKIVEKYPCAFPRWIGPFQAFLYIYDPDYAKTFLSRT (1)
DPKSNFLYKFMTASV
1563 GKGLVNLSGPKWSQHRRLLTPGFHFNTLKSFVEVMAQSVNIML 1435
NKWEKICGSQNTLLDIYEHINLMTLDVLMKCIFSWETNCQTDSSHDNYVKATSEGSNILMQR
LFNYFYHYDLIFKLSPLGHRLREVNKILHHHTDKIVKNRRNSLKDENKQTNTQKRKYRDF
LDIVLSAQAENDSFTDADLWSEVNTFMVAGHD
SVSAGISWLLYHLALYPEHQEKCREEIRAILGDGSSITWDQLSEM
SYTTMCIKESLRLAPPAVSISRQLSKPITFPDGRSLPAGMTVVLSIWGLHHNPAVWENPE
VFDPLRFSQECNKRHSHAYLPFSSGPRNCIGQNFAIAEIKVIVALI
LLRFQMRVEPTKPV
VFVPYIFIKPKKGIYLHLKKLP*
CYP4X1 Sus scrofa (pig)
DB802053.1 DB802658.1
MESSWLETHWARPLHLALVFCLALGLLQAVKLYLQRQRLLRDLRPFPSPPSHWFYGHQKI
IQNGGMETLGEITDKYPRAFPFWLGPFQAFFFIYDPDYAKTLLSRPDPKSNFLYKFMDPV
VGKGLLNLNGPKWFQHRRLLTPGLHLNALKSHVEIMAHSVNTMLGKWERICGTEDTLLEI
SAHVTLLTLDIIMKCVFGLETNCQINSTYDHYVKAVNEGSNLIFYRVYNFLYHHDIIFKF
SPKGHRFLELRKILHPYTAKIIQAGKNSLMNENQQGNTQKRKY
RNIFDIALSAQAENGDSFSDTDLRSEVNTFLLAGHETMTGGLT
WLLYHLALYPEHQERCREEIRSILGDGSSITWGQLGEMSYTTMCIKESLRLAPPVLSFSR
ELSKPITFSDGRSLPAGITVVCSIWGLHHNPAIWENPQVFDPLRFSQENNDKRHCYAYLP
FSAGPRNCVGQQFAMAELKAAVALILLRFSLTAEATRPLVSRPNIFLKPKNGLYLHLKKLP*
Cyp4x1 mouse
No accession number
Berthold Gottgens
Approx. 410 amino acids covered with some missing parts
66% identical to 4X1 human
Cyp4x1 mouse
GenEMBL AJ297131 runs from 112000 to 138000 on the minus strand
NT_039264.1, NT_039685.1
MEASWLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQK
FLQEDNMETLDEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSRT
GRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVML
DKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQIN
STYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYT
EKIIQDRKKILKNQVKQDDTQTSQIFLDIVLSAQ
GKEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITW
EQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHSLPAG
MTVVLSIWGLHHNPAVWNDPK
VFDPLRFTKENSDQRHPCAFLPFSSGP
RNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKL
CYP4X1 rat
no accession number
Johan Bylund and David R. Harder
submitted to nomenclature committee 9/26/01
91% identical to CYP4X1 mouse, 69% to 4X1 human
4Y Subfamily
CYP4Y1 Mytilus galloprovincialis (blue mussel)
no accession number
Mark Snyder
submitted to nomenclature committee
4Z Subfamily
CYP4Z1 human
GenEMBL AY262056 AJ131016 AC026935 161971-176942
ESTs H21976, H21977, H25577, H25624
Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
Full length seq now available on genomic DNA
52% to 4A11 52% to 4X1
because the sequence is the same percent identity to
4A11 and 4X1 and this is less than 55%
and the sequence does not cluster with CYP4As on a tree
the earlier name of CYP4Z1 is being resurrected.
This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD
STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
EKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV
CYP4Z2P human
NT_004386.11|Hs1_4543 92% to 4Z1 add full length version
652145 TKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDG 651978
CYP4Z2P human
AL731892.5 94% to 4Z1 1 stop codon in exon 8
67693 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPAHWFYGHKES 67514
66240 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQ 66103
54555 DPKSAVSHKILESWV 54511
52843 GRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMML 52715
50555 NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD 50433
50353 STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 50198
40609 EKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKV 40502
35393 ENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITW 35205
27034 EHLSQMPYATMCIKECLRLYAPVVNISQLLDKPITFPDGRSLPA 26903
12988 GITVFINIWALHHNPYFWENPQ 12923
11873 VFNPLRFSRESSEKMHPYAFIPFSAG 11796
10762 PRNCIGQHFAIIGCKVAVALTLLCFELAPDYSRPPQPVRQMLLKSKNGIHVFAKKV 10595
CYP4Z2P human
AK097373 mRNA 15-JUL-2002
breast, tumor tissue cDNA to mRNA
42 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYRRRRWTIRAMHLFPAPPAHWFYGHKES 221
222 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESW 401
402 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQNSRLELF 581
582 QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS 761
762 SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKSENTKD 935
936 FSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITWEH 1115
1116LSQMPYATMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGL 1247
4AA Subfamily
Cyp4aa1 Drosophila melanogaster
AC004516, AC004304, AC005556, AC004426
This sequence was called CYP47 initially, but trees with the C-terminal
Sequence clearly place it in the 4 family. Since all the letters of the
alphabet have been used, I have had to start using double letters to
indicate the subfamily. This will permit naming 576 subfamilies with
double letters and 24 with single letters for a total of 600 subfamiles.
I don't think we will ever need that many.
35% to 4D2 35% to 4C1
Cyp4aa1 Drosophila melanogaster
GenEMBL AC020355 comp(15477-16779) and AC007579 comp(38212-38842)
MHLRLLSPPQLERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPF
LGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVF
FYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV
GTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLL
DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRD
FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMT
DLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY
PDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPV
TGKTTIAATFRITLRASGGLWVRLKERDHPLIAH
Cyp4aa1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4AA1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPi2r2
CYP4AA1 Lutzomyia longipalpis Jacobina (phlebotomine sandfly)
GenEMBL AM096652 AM096653 AM096654 AM096655
63% to anoph. 4AA1, 62% to Drosophila 4AA1
4 FLKLLHNFLGNGLITSSGDKWNVHRKLIQPSFHLNILEKFIGTFNDSSQCLLDKFKSVEG 183
184 EVNITDFVNNCVLDILNEAVLGVPVFREDKEKEKSPFRQGKVVMPYRVTRPWLLLNWVY 360
361 KLTDTAASELNQKKQLDNFTRKMIHIRREAKRTGNLGERKCLLDYLIDISDQVPDFTEDD 540
541 IINEACTFMLAGQDSVGAAVAFSFFMLAQNPDCQKKCIEEIDNIFDGDTRAPTMRDLRE 717
718 MRYLEQCIKETLRLYPSVPLLARRLGEDIRVGEHTLIAGSHIFIVPYAIHRLPYIYPDPE 897
KFDPDRFLPEEVEKRNPYAFLPFSAGPRNCIGHKFAILEMKTVISKILR 379
378 HFTLHPVEGKEDLHPSFRVTLRATVGLWIKLQRRDKV 268
CYP4AA1 Apis mellifera (honeybee)
48% to Drosophila Cyp4aa1 (ortholog)
MGKVSSSLTSIYILYILRTYIRSIIYISQLNGPKTIPIIGNANSILKEN (1)
FLYRLAYESQMYGRIVRIWLTIFPYVMFLEPEDIQLILNNAKHTQKVFFYKLLDNFLGKGL
ITRDIKSWRIHRRLLQPAFHLHVLEKFTNTFAKHADHLMNKILEKNNQEINITTFINDSVYNILS (1)
ETVLGINRINRINEMDDLPFRK (2)
GQIMLLYRMIRPWLLIEWIYRLTKYGREEEKQRKNLFDTCFKMVKEKRDLLQSKDRISNNDIKKNK
NISLLEYMVEINEKNPCFSDEDIVEECCTFMLAGQDSVGTATAMTIFLLANHPEWQNKCIEEIDEI
FNGDTRFPTISDLKEMKCLEMCIKESLRLYPSVPIIGRTLGEDIKI (1)
GKHIIPAGCSVLISPYSTHHLPHHFPDPDTFKPERFNSENSEKRHPYAYIPFSAGPRNCI (1)
GYKFAMLEMKSIISAILRKCRLQSIPGKKEIRPKFRMTIRAQGGLWVKIIERDQILKSIAA*
CYP4AA1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973810 AAJJ01000447.1
44% to CYP4aa1 Drosophila, 37% to CYP4BN8
41% to 4aa1 bee, 43% to 4aa1 Anopheles
MWTDICTYLVILAVMLMSIYFKNYIRSVYLAFQLSGPPAVPLIGNVL
LMKNDRSKYQFFRGHILS (1?)
EMYSPFMRCWLSIFPVFFIYEPKALQLIMGTNRYTSKNIFYNCLHNVVGDGLITSS (1)
GEIWKQHRKLIQPYFHISVLKVYFDIFYKWS
41760 MAMVQDLENETEVNITKYANKFVFD (0)
SQYWAFLGKDQSRLLIGGNLVQHIHQ (1)
CQFLMLHRITRPWLLFNTIFKRTDFSKVEENQKNILQQYTKS (0)
41348 ILDGKKQNSHGTAMNNLMEMMMEISNMNPEFTDDDIVNETCTFMLA (0)
41162 GQDSVGAALSFALYSLAAHQDIQEKVVQELNGIFKDGNQAATFEDVAEMKYLEQCIKETLRLYPSVPM
ITRKITEDVPL 40926 (1)
GKYTLPTGTNIVISPFVTHRLPHVFPDPLKFDPDRFS
PENKAKIHPYGFIPFSAGPRNCI (1)
GYKFAIIELKTVLSQILRKYHVSLVPGREKLILSYRMTLKAKKGIWLRLKKRSV*
CYP4AA1 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
50% to 4AA1 Apis, 45% to 4aa1 Drosophila probable ortholog
CYP4AA1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB1 Solenopsis invicta (fire ant)
GenEMBL AY345970
Nannan Liu
submitted to nomenclature committee 8/16/99
51% to 4Q2 and 4M4
MPRQHLINLLFSLCDKYYPIFRTWAFFEGFVSIRHPDDLEVILN
SSTNIEKSRIYSVLHPWFGLGLLTSGGSKWHSRRKILTPTFHFNILQQFVEILIEEGE
SMTNSLKNAGSTITKDLVPLISEHTLNAICETAMGTSLQGMNSVQQEYRKAVHRMGEL
FIYRLVRHWLISDWIFALTSQGREQVKILKILHGFTNKIIAERKDYHKRTNGQYLKNF
NQSIITDNEEIVGSKKKRLAMLDFLIYASQEGHLTDVDIREEVDTFMFEGHDTTSTSL
CYTLALLAENKDIQDRVRQEVDLVMQENEGKLTIKSLQNLQYLERCIKESLRLYPSVY
FISRITTEEAQLKSHLIPVGTIMHLHIYGVHRDPNFWPNPDVFDPDRFLPENSRNRHP
YSYIPFSAGPRNCIGQRFAMLEMKAMIAPLIHNFCLEPVDLLKNLRVGPDLVLRPLGG
HRIKFIPIATKCI
CYP4AB2 Solenopsis invicta (red imported fireant)
GenEMBL AY345971
Nannan Liu
submitted to nomenclature committee 9/24/02
43% to 4C1 and 43% to 4M7 71% to CYP4AB1
Note: formerly named CYP4AS1 by mistake
MFIALLLIIIVVYLMCHCYAQYGPNGRLINKIPGPPGYPIIGNL
FNLLESREQFWETLSILNEQYYPIYKLRAFFNSLVFIRHPDDLEIILNNTKHISKSNL
YDALRPWLGMGLLTSGGSKWHLRRKILTPTFHFNILQQFVEILIEEGESMTRSLKNAG
GTITKDLVPFISEYTLNAICETAMGTSLQEMGSFQQQYRKAVHRMGELLVYRAMRPWL
KYDWIFSLTSKGREQKKLLKILHGFTEKVIAKRKDYHKRTKGQYLKNLNKDVVPNETE
TIGIKKKRFAMLDLLIQASQEGLLTDFDIREEVDTFMFEGFDTTGMAMCFILSLLAEH
KDIQDCVRKEIDAVMQENQGKLNMKSLQDLQYLERCIKEALRLYPSVYFISRITSEET
ELKTYLIPAGTLVILNFYITHRDSNFWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGP
RNCIGQRFALLELKAMLVPLIYNFYLEPVDYLENQRFGIDMILRSLDPCRLKFVPIAT
EGI
CYP4AB3 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5748 (1270-4633)
50% to CYP4AB2 fire ant
formerly CYP4AZ1
renamed to recognize a large hymenopteran clade
N-term extended to match other CYP4AB seqs.
MISAILFFIFLLATLHYFLLHHRKFGKMINLIPGPEPLPILGNIPTFHNISP (1)
SELWKFLTQLSKQYYPIYRMWTFLEAYVHICHPDDIE (0)
TILGNIKFTKKGFGYKYLKPWFNTGLLTSS (1)
GHKWHVRRKILTSAFHFNVLRQFVDIFIEDAERLIKTLESEEGIFVENLLQLTSEHTLNVIC (1)
ETAMGTSLKNKEKFQYEYRKAVYNMGCIFANR(2)
IVKPWFYYDFFFNLSPEGWQQSKLLKILHNFTRK(0)
IIQERKEYHDKTNGRYLNDFHENINENDNNNDYND(1)
FRRKRLAMLDLLIEAHRNNKIDDEGIREEVDTFMFR(0)
GHDTTAISFCFSIMLLAEHKEIQ(0)
DRARAEIKAAIEENGGKLNITVLQNLPYLERCIKESLRLFPSVPRISRKLETSVKL (1)
SNYEIPSNTIINVNIFDTHRDPKFWPNPNKFDPDRFLPENSKKRHPYAYVPFSAGPRNCI (1)
GQRFAMLELKTYLGLLLYNYYFEPIDYLKDVTFVSGIVLRLENPVRMKFIPVKKIC*
CYP4AB4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB6 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB8 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB9 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB10 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB11 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB11-de7b8b10b11b Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB12 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB13 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB14 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB15 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB16 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB16-de1b2b Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB16-de1c2c11c12c Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB17P Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB18 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB19 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB20 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB21 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB22 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB23 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB24 Solenopsis invicta (Lausanne fire ant)
EE131689 EST
N-term region of CYP4AB
65% to CYP4AB2
YPIIGNTIKLINLGVLRIWKYIICTSSDKYYPIWKLRSFFESLVIIRHPDDMETILN
NTKHINKSKLYDILHPWLGTGLLTSTDSKWHTRRKILTPTFHFNI
CYP4AB25 Solenopsis invicta (Lausanne fire ant)
EE142405 EST
46% to CYP4AB2
MFVTLLILCVSIILLYFITYYGRFRRLIGKVPSKPDLPFIGNALEFFMYS
QEKIWEAERLANKTHTIYTFWCGPIAFIATRDPDDIEKILSNTTQHLSKGYIYNLLHPWL
GTGLLTSEGAKWRKRRKILTPTFHFTILKEFVDIFTEESNRMIKYLKNIEGSNIDNLMNF
ISHHTLNAICG
CYP4AB26 Solenopsis invicta (Lausanne fire ant)
EE148664.1 EE147029.1
MAY JOIN WITH 4AB24 82% TO 4AB2, 72% TO 4AB1
TLNAICETAMGI
SLQGLGSFQQQYRKAVHQMGEFIVYRLLRQWLKNDWIFSLTPRGREQAKL
LKILHGFTEKIIKERKDYHKLTNGQYLKNLNKDAVADEEIIGIRRKRLAMLDLLIQASQE
GLLTDKDIREEVDTFTFEGHDTTSSGICFTLALLAEHKDIQERVRKEIDVIMKENQEKLT
MKSLQDLQYLERCIKEALRLYPGVFFISRNTSEKVQLKSYLIPAGTLLHLNIFGVHRDPK
FWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGPRNCIGQRFALLELKAMLVPLIYNFYL
EPVDYLENQRFGIDMILRSLDPCRLKFAPIATEGI*
CYP4AB27 Solenopsis invicta (Lausanne fire ant)
EE134101 EST
70% to CYP4AB2
DGDHSTGSKWQSRRRLLTPIFHFNALQQFTEILIEEGESMANSLKNAADTITKDLV
PFISEHTLNAICEAVVGISPQKMGSFQHQYWTAVYRINEFIIYR
Cyp4ac1 Drosophila melanogaster
GenEMBL AC017771 comp(24745-26507)
Cyp4ac1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4ac2 Drosophila melanogaster
GenEMBL AC017771 comp(22220-24109)
Cyp4ac2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4ac3 Drosophila melanogaster
GenEMBL AC017771 comp(20241-21996)
Cyp4ad1 Drosophila melanogaster
AC020402 comp(36565-39829)
Cyp4ad1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4ae1 Drosophila melanogaster
GenEMBL AL009194 16210-17867
Old Cyp4e4 renamed
Cyp4ae1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4AE2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4AE
59% to 4AE1 (148 aa)
Cyp4af1x discontinued name see Cyp4ad1
CYP4AG1X discontinued number assigned to sea bass 4F7 seq due to
An error at the C-terminal of this sequence (see 4F7 above)
CYP4AH1X discontinued name see CYP4V2 human
CYP4AJ1 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF243506
Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
Insecticide Resistance Associated Cytochrome P450 Gene Fragments
from D. v. virgifera
Unpublished
DvP450-1
CYP4AK1 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF257100
Isolation of family 4 cytochrome P450 gene fragments from
insecticide-resistant and -susceptible western corn rootworms
Unpublished
DvP450-3
CYP4AL1 Mytilus edulis planulatus (Australasian version of common mussel)
No accession number
Karl Herron
46% to 4T4 from Xenopus, 38% to 4Y1 from blue mussel,
39% to abalone 4C17
submitted to nomenclature committee Jan. 30, 2001
I-helix to heme region
CYP4AM1 Plebidonax deltoides (Pipi or Goolwa cockle, a type of clam)
No accession number
Karl Herron
48% to 4T4 Xenopus 48% to 4A20
partial seq. from I-helix to heme
submitted to nomenclature committee Oct. 9, 2001
CYP4AN1 Daphnia pulex (Daphnia, water flea)
BQ703378 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.3 205 aa
53% to 4B1 52% to 4V2 54% to 4v3 53% to 4W1 93% to 4AN2
CYP4AN2 Daphnia pulex (Daphnia, water flea)
BQ703379 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.3 prime 209 aa
57% to 4C17 55% to 4C18 93% to 4AN1
CYP4AN3X Daphnia pulex (Daphnia, water flea)
BQ703375 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.1 149 aa
58% to 4v3 mouse 59% to 4c24 66% to 4AN2
renamed CYP4BY5v2 based on genomic full seq
CYP4AN4 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN5 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN6 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN7 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN8 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN9 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN10 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AN11 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP1 Daphnia pulex (Daphnia, water flea)
BQ703376 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.2 197 aa
49% to 4V2 50% to 37A1 51% to 4C21 74% to 4AP2
CYP4AP2 Daphnia pulex (Daphnia, water flea)
BQ703377 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.2 prime 187 aa
49% to 4V2 47% to 4C1 51% to 4C21 74% to 4AP1
CYP4AP3 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP4 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP5 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP6 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP7 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AP8 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4AQ1X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
57% to 4H9 fragment (from Anopheles albimanus)
but 44% to 4H24 so new 4 subfamily related to 4H
same seq as CYP4H26 above
CYP4AR1 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
41% to 4D2 lower to other 4Ds
CYP4AR1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r2
Note very similar to CYP4K2 (almost in the same subfamily)
CYP4AR2 Aedes aegypti (yellow fever mosquito)
CYP4AR3 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 11
70% to CYP4AR2 Aedes, 45% to 4AR1 Anoph.
CYP4AR3 Culex pipiens
CYP4AR4 Culex pipiens
CYP4AS1X Solenopsis invicta (red imported fireant) renamed CYP4AB2
No accession number
Nannan Liu
submitted to nomenclature committee 9/24/02
43% to 4C1 and 43% to 4M7 71% to CYP4AB1
CYP4AT1 Capitella capitata (polychaete worm)
No accession number
Bo Li
submitted to nomenclature committee 2/3/2004
Most similar to CYP4T and CYP4F
CYP4AU1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #14 HaCypZ014a-v3Pep revised from earlier seq.
51% to 4M4 235aa fragment from C-term
CYP4AU1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000052 4 aa diffs to CYP4AU1 of Grubor in the C-term part
53% TO CYP4AU2, 38% to CYP341A3, 36% to CYP4G25
CYP4AU2 Bombyx mori (silkworm)
No accession number
See silkworm page for details
CYP4AU3 Heliconius erato (red postman or red passion flower butterfly)
GenEMBL EST EL596754.1
N-term 51% to CYP4AU2
MFVAVLICLFCCLYYLHFRRKRKQLYEFSKSI
PSVGNLPVVGHSHWFIGGPEKILKNIQTLAQMIEDSGGISSIWLGPTLYVVTMNPEDVQK
ILENSLQKDFSYKFLQEWLGNGLFVAPVDLWKVHRRLLLPVFHNRIIEDYIDVFGEQGSV
LVKRMGEKVGKSEFDVFPYITSCMLDIVFETAMGEKMDVQHNPDTPYLRARNTVISI
CYP4AV1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2000
41% to CYP4C3 Drosophila.
CYP4AV2 Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
65% to CYP4AV1 Apis, 82% to CYP4AV3, 81% to CYP4AV4
CYP4AV3 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
Philotrypesis sp4
68% to CYP4AV1 Apis, 97% to CYP4AV4, 82% to CYP4AV2
CYP4AV4 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
Philotrypesis sp5
66% to CYP4AV1 Apis, 97% to CYP4AV3, 81% to CYP4AV2
CYP4AV5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AW1 Phyllopertha diversa (scarab beetle)
GenEMBL AY605086.1
Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
Leal,W.S.
Pheromone anosmia in a scarab beetle induced by in vivo inhibition
of a pheromone-degrading enzyme
Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
Submitted to nomenclature committee Nov. 4, 2003
Clone name Cyp4Pd1
41% to CYP4C1 40% to CYP4D2
61% to CYP4W2
CYP4AW2 Phyllopertha diversa (scarab beetle)
GenEMBL AY605087.1
Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
Leal,W.S.
Pheromone anosmia in a scarab beetle induced by in vivo inhibition
of a pheromone-degrading enzyme
Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
Submitted to nomenclature committee Nov. 4, 2003
Clone name Cyp4Pd2
42% to CYP4C1 42% to CYP4D2
61% to CYP4W2
CYP4AX1 Bombyx mori (silkworm)
BAAB01092965.1 BAAB01135526.1 BAAB01183645.1
50% to CYP4S4
See silkworm page for sequence
CYP4AX2 Bombyx mori (silkworm)
BAAB01152933.1 BAAB01194854.1 BAAB01058563.1
BAAB01102208.1 BAAB01008375.1
94% to CYP4AX1
See silkworm page for sequence
CYP4AY1 Ips paraconfusus (a bark beetle, California fivespined ips)
No accession number
Dezene Huber
Submitted to nomenclature committee Nov. 10, 2004
38% to CYP4AW1 from scarab beetle p= e-88
40% to CYP4S3 p= e-77, better percent match but poorer p value.
CYP4AY2 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
56% to 4AY1, full length
CYP4AZ1X Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5748 (1270-4633)
50% to CYP4AB2 fire ant
renamed CYP4AB3 to recognize a large hymenopteran clade
CYP4BA1X Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_49183273 (824-692) partial seq.
52% to CYP4AA1
name changed to CYP4AA1 (ortholog)
CYP4BB1 Nereis virens (annelid polychaete worm, clamworm, sandworm)
GenEMBL AY453407.1 (partial seq)
Rewitz KF, Kjellerup C, Jorgensen A, Petersen C, Andersen O.
Identification of two Nereis virens (Annelida: Polychaeta)
cytochromes P450 and induction by xenobiotics.
Comp Biochem Physiol C Toxicol Pharmacol. 138, 89-96 2004.
Clone name CYP4(1), CYP41 in abstract
Submitted to nomenclature committee April 29, 2005 (full seq)
41% to 4f15 mouse, most similar to vertebrate 4F seqs.
CYP4BC1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CD449348, CF075894.1, CO741868.1
David Drane
4clan 52% to 4C3(bottom half only)
N-term and C-term
These ESTs are missing the middle region between
The C-HELIX and the I-helix.
The ESTs are continuous across the gap region
Like several exons have been skipped.
MFFLNVVIYFLIGFLVTRLVKIFLKYRRIASHIDK
IAGPPRLWLPVGNALQLSGNHFKFFQQIRQLAKDYREQSPTGALRLWIGPYPYVIMVKGK
AAEAVLSSYKFLEKGPDYDLVHPWLGTGLLTSTGDKWRSRRKFLTPAFLDLL
LSAKTEDGKVLDNASIREEVDTFMFEGHDTTSVAAAFAVFLLGNHQDVQQKAYEELRQIF
GDSDRAPTTEDLKNMRYLDCVLKESLRLYPSVPMITRKCNEDYKLPDSDIIIPEGSIVSI
FIFALGRDPDMFPEPDRFDPERFSDTKSARHRPFDYVPFSAGPRNCIGQKFAVMEEKTIL
STILRSYTIQSVEDPETLRIAGELITRPIDGISVKLFR
CYP4BD1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4AW1, full length
CYP4BD2 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
79% to 4BD1 Ips paraconfusus, 54% to CYP4BN4
clone name EST 25A04
CYP4BE1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
45% to 4V2, 44% to 4C1 55% to 4C18 lobster
missing about 88 aa at N-term
CYP4BE2 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
65% to 4BE1
CYP4BF1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
50% to 4BE1, full length sequence
53% to 4AN3 Daphnia from I-helix to heme
CYP4BF2 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee Aug. 15, 2007
59% to 4BF1 Ips paraconfusus
I-helix to heme region
CYP4BF2 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
Only two amino acid differences to Philotrypesis pilosa CYP4BF2
In the overlapping region
This is a clear ortholog so it has the same name
I-helix to heme region, with some missing sequence
CYP4BG1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4J9 full length sequence
52% to 4C21 from I-helix to heme
CYP4BH1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4AW1 full length sequence
CYP4BJ1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
41% to 4BF1, missing sequence after heme signature
CYP4BJ2 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
57% to CYP4BJ1
This seq will be less than 55% identical to 4BJ1 in full length,
so the name may not be correct. However, the next closest match
is 46% so this looks like it may be an ortholog.
CYP4BJ2 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee Aug. 15, 2007
57% to 4BJ1 Ips paraconfusus
Only 3 amino acid differences to Ceratosolen solmsi martchali CYP4BJ2
This is a clear ortholog so it has the same name
I-helix to heme region
CYP4BK1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 60_1_ext
41% to 4F11, 43% to 4F6
57% to part of CYP342A1 Nereis AY453408, but not to whole seq
same region is 57% to CYP4F11
CYP4BK1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-2a
CYP4BK2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-2b
CYP4BL1v1X Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 54_4_F_ext
52% to part of seq CYP4FA1 AF163824.1 Coscinasterias muricata
47% to CYP4Y1 Mytilus galloprovincialis (blue mussel) AF072855 partial
seq
Note: these old sequences have been replaced by newer versions below
CYP4BL1v2X Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 54_9_F_ext
97% to CYP4BL1v1X probable allele
Note: these old sequences have been replaced by newer versions below
CYP4BL1v1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a1v1
CYP4BL1v2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a1v2 (old CYP4BL1v1X above)
CYP4BL1v3 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a2
CYP4BL2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3c possible hybrid of CYP4BL1 (N-term)
and 4BL3 (C-term) genes.
CYP4BL3 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b3
CYP4BL4 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b1
CYP4BL5 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #1
CYP4BL6 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #2
CYP4BL7 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #3
CYP4BL8 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #4
CYP4BL9 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #5
possible hybrid of CYP4BL3 or CYP4BL8 (N-term) with CYP4BL1 (C-term)
CYP4BM1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966563
poor match 42% to 4C3
MDFTYLLLFTFFTIGFVNFCKWLKDRKRIWDAIEPIGGEKWYPLIGTCLELIKTKRKDFYDVYCARNMKY
GPFFRTWMGFIPAVHVMKPDHVERILSSTVNLTKGDNYRFVVPWLGEGLITGSNHKKWRVHRKLITPTFH
FSILDNMMEVMAEKGQFLAEQLVPKANGQFFNIYPFLTLCELDIICETAMGVEVNAMKHSQSEYVRSVYG
ISDIMLYRMFHPYLHPDFVFNLSSKGRQHKKYLSILHGFTRKVIQERKEKLTSGRDVVQELSEEDKLLGK
KKRLAFLDLLLEANKNSEGGLTDEDIREEVDTFMFAGHDTSTVTVGWTLFTLSNYPEYQEKVHQELDEIF
QGEERPITPQDVLKMQYLDKVIKETQRLIPVVPVIARTLDQDLEIVASSRTIPAGVMVVIHLARLHKDPD
QFPEPDRFDPERFLPENVSKRHPYSFVPFSAGPRNCLGQKFALRNTKVLLASILRKYKVRAEKKIDEMKY
NIEIVLRPQGGLSVALEPRRR
CYP4BN1 Tribolium castaneum (red flour beetle)
GenEMBL XP_971854
66% to 4BN4, 48% to 4AW1, 48% to 4BH1
MGALALVVFAVTTLLFLIWFIRLVRKNNDYYKDIPGPRPLFFFGNVFEVSTTRDILNVMHKYALQFNGLY
KIHLGPVRKLIIASDYKFLECVLSSMKILNKSEDYLYLRPWLGTGLLTSDGPKWKKHRKIITPAFHFQIL
EQFVEVFESGGNRFVQQLQKEVGKKSVDIYPYVTLCTLDIICESAMGISINAQFDDNSDYVRSVKAMCRI
TMERLFHLLEMNDVTYPLTKNYYTQKKSLNVLHNQTNSVINRRRKELENKTEAINVTNEDKADNNDTLFG
RNKKAFLDLLLQATVDGRPLTQEEIREEVDTFMFEGHDTTASAISFAIYCLANNADVQAKAYEEQIALFG
GNKSPAVTYSDLQSMKYLELVIKETLRLYPSVPMFARKTSEPVQYENIFIPEGVTVNIFAYGIHRDPKYF
KDPEKFDPSRFETVDGKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKVLRNFELQPATPTHTVQLAAES
VLKSANGVKIALKNRN
CYP4BN2 Tribolium castaneum (red flour beetle)
GenEMBL XP_971905
72% to 4BN5
MILPILLCLIFSFLIWSLYQTCKKNSFYKNIPGPSGVPIFGIAFEFKSTQ (1)
DVLINLTSYIKTYGDIVTAKIGPFR
86921 RYLLVSDYNFLECVLSSTKLIKKSHHYTFFQGWLGTGLLTAD (1)
GAKWKTHRRILTPAFHFQILEQ 86682
FIEVFEKCGDVLVKKFENEVGRKSFDIYPYVTLHTLDVICESIMGISVNAQNNSTSEYVNSVKNICKIFV
ERSVSPLQMCRFMYPFTKNYWAEQKALKILHQHTNSVIDARRKELHKAENGHNTNPKKSKKPFLDLLLET
KIDGIPLTQEEIREEVDTFMFEGHDTTASAISFTLYSLANNLHVQEKAVDEQKKIFGERKDVTAAYADLQ
NMKYLENIIKESLRLYPSVPFYNREITDDIMFDNKLLPKGDTIMVFAFAIHRNAKYFDNPEQFNPDRFND
LENKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKILRKYKLLPADPQHELNLVSELILKSSNGIKISIE
PRC
CYP4BN3 Tribolium castaneum (red flour beetle)
GenEMBL XP_966858, XP_975914
56% to 4BN1
MALLTDVFLPLVIILLIFWYWYRSQKNKKYYQNVATPPTVPILGNALDFTTTTELLGTFMRYRKDYGGLV
KVHIGPLRHFLLVSDYKMLEYLLSSPKIVDKSEDYKFLSSWLGTGLLLADGGPKWKKHRKILTPAFHFQI
LEQFVDVFDSCSNVLIQKLDKEVGNTSVDVYPFVTLFTLDVICESTMGTKINAQDDVTSDYVQSVKHMCR
IIIERSISPVQMYDFLFVFTRNYFIQRRALRILHDKADGVISQRLRELQAQTKTDSEGDSEGIKKKKAFL
DLILEAKVDGKPLSQDDIRQEVETFMFAGHDTTASAISFTLYCLANYPEVQKMAYEEQLSIFEDNNEPDV
TYANLQSMKYLELVIKETLRLYPSVPIIGRQSGEDFQF
DNSWIPKGDTMLLFLYGIHRDPKYFKDPEVFD
PNRFENPDNKMPYSYIPFSAGPRNCIGQKFAMLEMKCVLSKILRKFELQPAVPQHNLLLTAETVLKSANG
IKIGIKLRK
CYP4BN4 Tribolium castaneum (red flour beetle)
GenEMBL XP_971963
66% to 4BN1, 52% to 4AW1, 51% to 4BD1
MCCCFPLALAALHWPRDARVDDCRLCYPMPMRDAGQQLLQHQKLSGTLRMDTQAAAKTPTLALRHDAMQS
FNRPTFYLVLDIMMKYMKIYGGVVKFHGGPIDKTLLVSDYNFLENVLSSTKILNKTDDYKFLHSWLGTGL
LTSAGPKWKKHRRILTPAFHFKILEQFIDVFESAGNKLVKKLEKVVGKDSVDIYPFVTLCTLDIICETAM
GIKINAQDNGESEYVRSVKQMCKIIIERSFSLLQMINLTYPLTKNFYIEKNALKILHQQTNSVINQRRQE
LKNQSKNIEQENDLGTKTRKAFLDLILEATVDGRPLTDTEIREEVDTFMFEGHDTTASAISFALFCLATH
PEVQARALEEQKALFGDTKNPTPTYTDLQNMKYLEQVIKEALRLYPSVPFHGRKTNEAVEFNNGTVVPKD
VTITVFTYGIHRNPEYFKDPEKFDPSRFDTIDGKLPYSFIPFSAGPRNCIGQKFAMLELKSTLSKVVRKF
ELRPATPEHKLQLTAETVLKSVNGIKISLKLRQ
CYP4BN5 Tribolium castaneum (red flour beetle)
GenEMBL XP_967939
72% to 4BN2
MITIVIILIFILVSINFITKYLKKLKQNKDFYQNIRGPRGLPILGSALDFKTTK (1)
DVLQNLINYTRDYGEVVTAQIGPFHRYILVSNYDFLECVLSSTKLSSKSHNYNFLRPWLGTGLLTSD (1)
GAKWKTHRRILTPAFHFQILEQFIEVFEKCGNTLLEKLRNEVDKETCDIYPYVTMCTLDIICESIM
GISINAQEDSTSDYVQSVKNVCRIMVERSISPLQMCPFMYPLTKNYWTEKKSLKILHKQTNDVINARRKE
LESSKEVSSYEENFTKKKKPFLDLLLETKIDNRLLTQEEIREEVDTFMFEGHDTTASAVSFTLFCLANNL
ESQQKAFEEQQAIFGNIQNVTASYTDLQNMKYLEQVIKEALRLYPSVPFYGREITENVEYDGKLLPKGDI
LLIFAFGIHRNEKYFPNPEKFDPDRFHNMDNKTPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKVLRQYKL
LPTTPQHELELVGETILKSTNGIKIRVTLRN
CYP4BN6 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000217.1, DT795816 = EST
76% to 4BN1, 46% to 4d2, 50% to 4D24,
51% to 4AW1, 43% to 4H8
MNIILEFFSALAVIIVLSWWYLFLKNYKVGKFFKNFSGPPGVPLLGNALDFKNKTK (1)
41530 GVLPAFLNYNKNFGGLVKVQIGPFRKLLLVSDYKFLEFVLSSTKIINKSQNYRTMLPWLGTGLLTS 41727
41728 EGIKWKKHRRIITPTFHFKILEQFINSFDAAGDVMINKLRKKVGIESVDIYPFVTLCALD 41907
41908 IIC (1) 41916
41969 ETAMGTTINAQNNEESEYVTSVKEMGRIIIERAIAPQKNNEFLFRFTKDY 42118
42119 QLQKSALKVLHNYTNNVISKRREELLKDQASKVSENVIDMGIKKKMAFLDLLLQATVDGR 42298
42299 PLTNEEIREEVDTFMFE (0)
GHDTTASGISFALYCLANNPEAQEKAYEEQVALFGKEKKPIVSYSDLQEMKYLELVIKEALRLYP
SVPFYARETNQEVEFGDI 42696
42697 KIPKGVNITIFAYGIHRDPKYFPEPDKFDPGRFETIDGKLPYAYIPFSAGPRNCI (1) 42861
42915 GQKFAMLEMKSTISKVLRNFKLCPATPHHTLDLVAETVLKSDNGVRLSLMERQ* 43076
CYP4BN7 Tribolium castaneum (red flour beetle)
GenEMBL XP_972577
66% to CYP4BN8
MYLIAIVIVLISLYLIVKPVKKTGNIDDFPEPPSKVFFGHALDAKSTTEILNVTTNYVKKYGKIVKLRLG
PFFKALVVTDYKLVEFFLSSNSLLTKSQNYAFARSWLGNGLILANGTHWKQHRKILTPAFHLEILREYLE
TFDSVGRIFIEKLKSLDNVQSVDLDALVPLCTLDVICETAMGTKINAQKGENSEYVSSVKEMCRIIVARF
LSPLKILKCTYWMTHDFYTERKVVNILHSFTSKVIDGRKTNRNETEKSGKKKAFLDLLLKFSDIEKLSDR
DIREEVDTFMFAGHDTTATGVCFALYLLANNPEVQEKVLSEQKELFGDEKNPCVTYQELQNMKYLEYVIK
ETLRLYPSVPVIGRYLKEDTTFGDRVISAKTNVAIFIYGIHRNPDYFPEPEKFIPERFENMTNLPPYAYI
PFSAGPRNCIGQKFAMLEMKSLISKVIRHFELTPANPHHELVLAAETVLKSANGIKIGLRARSENKM
CYP4BN8 Tribolium castaneum (red flour beetle)
GenEMBL XP_972624, AAJJ01005264.1
66% to CYP4BN7, 55% to 4BN4
MFIFAALFFLIIFYLYHQNVKLNRILCTFPEPPKKFLLGHVLDITSTT (1)
DVLNVFSK YINNYGPTIKLRAATLFAGLGTTDYKLCELLLSNNRILSKSLNYQYAR
NWLGNGLLISDGDYWRRHRKILTPAFHFEILKQFVETFESVGKVFVEKLDISQGPSVDLPPLVTLCTLDV
ICETAMGTQINAQKGQNAKYVQSVREMCRILIDRGLSPLKILNNTYWMTKDYYIEKKSLKVLHSFTSSVI
EKRKAERNERNCTKLAFLDLLLKFSNEGELLTDQELREEVDTFMFEGHDTTASSISFVLFCLANHPEVQE
KVLREQNELFGDDKDPSVTYHELQKMKYLEQVIKETLRLYPAVPIIGRCTSEDITFGEHFIPKDTNIAIY
IYGIHRNPEHFPEPETFNPDRFKNSNSLPPYAYIPFSAGPRNCIGQKFAMLEIKSIVSRVVRCFELRPAE
PYHSLVLSAETVLKSANGIKIGIRKRI
CYP4BN9 Tribolium castaneum (red flour beetle)
GenEMBL XP_971513, AAJJ01000614.1 also has 4BN10
66% to CYP4BN10
MIVFTGYLIAIVLILFPLYYYYAKCYALEKFYHQFPSPPKTPFFGNALDLKTTK (1)
DLFQSFHRYVKAYGT
17128 MVHLKIGPFDHMLLCSNPKFLEFLLTSNTLLKKSPNLRYLVPWIGTGVATAY (1) 16970
16925 GPKWKLHRKLVTPAFHYS
VLSQFVNTFESSGNILVEKISKLCDGQKVDNFDLYPHITRCTFDIICETAMGTKSNVQTNETSVYFESIK
EMCRIFMSRTMAVFQRYDFIFRFSKDFHLQKKALDIIHNYSNEVIATKRKELDENVKQKESVDDLGRKEK
MVFLDMILNKAIDGHIFSQEAIRGEVDTFMFAGHDTTATAISFILLCIANHNEVQDKIIEEQERLFGCEK
NPKVTFAHLQEMQFLENVIKEGLRLYTPVPLYGRQIDKNVEFEGMLIPKGVNVVIFNHGVHMNPEFYPNP
EKFDPNRFESMEDKHPFAFIPFSAGPRVCIGKKFAILEIKSILSKIVRNFELFPASPSYELDLAAETVLK
SLNGIRIGIKRRETF
CYP4BN10 Tribolium castaneum (red flour beetle)
GenEMBL XP_971570
66% to CYP4BN9
MSVLTEFFIALVALILLPFYFYYTKIRRIENFFKHFPSPAGVPILGVAPEFKTTSSVLDNFHKYAKAHGT
MVHLKFGPFKHALLCTDTKFLEFLLSSNKLLKKSVNLRFLEPWIGTGLVTADGGPKWKTHRKLITPAFHF
KILEQFVDIFESGGDILVKKLSEVSGSKSCDIYPYITKCTLDIICETAMGTKVDVQNTENSAYFESIKEM
CRIFTVRTVGAFLSNDFIFRFSKDYKIQTKAVKVLHNHSNEVIVNKRKELKEKNNENTSDIDELGRKKKK
VFLDLILSATTDGQSLSPEEIREEVDTFMFGGHDTTGTATSFILYCIANNKEAQEKILEEQKQLFGDERS
PKVTYSTLQEMKYLENAIKEGLRLYSPVPIYGRLIDQDTEYNGTMIPKGVGVIIFAHGIHMNPKYYPNPE
KFDPSRFENTTGKDPFTFIPFSAGPRNCIGQKYAMLEIKSLVSKVVRNFELFPASPTHEMHLAPETVLKS
LNGVKIGLKMR
CYP4BN11 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000275
53% to CYP4BN4, 49% to CYP4BN6
73454 MEILFTLFILLLCLLLYFYNKYVYIFDKNLKDYPAPPQVPILGHTLDF (0) 73597
73690 LIFLGFLDVLLSYTHKYGDIVRIRPGPIRQLLLTSNYKLFEAVLSNAKITKKSADYKFFHRWLGTG 73887
73888 LLTSDGAKWKKHRQIITPTFHFQILENFVDVFEKNGKILTKQLEKHLNEDSVNVYGFVNL 74067
74068 CALDIIC (1) 74088
74133 EAAMGTSVKAQENMNSEYVRSVKDLLDTLMGRIFSPYKMIDFIYFFTEDYKKEMKALQ 74306
74307 VIHSYTRNVIKSRQAAINSGEFEQKTKKNFLDLLLAANEQQMTLEEIREE 74456
74457 VDTFMFA (0) 74477
74527 GHDTTASTISFALFCLANHPDEQ (0) 74595
74648 ARVYREQKDIFGDDFKRAVTFQDLKKMKYLEYVIKETLRLYPVGPFFSRELDKDVPFAG 74824
74825 KVLPKGLTITLFIYAMHRNPEYFPDPEKFNPSRFETFDGKMPFAFVPFGAGPRNCL (1) 74996
75039 GQKFAMLEMLSVVSRVVRTYKILPSIPRHEINVAAQVVLISTNGMRMRFEKR 75194
CYP4BN12v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4D262110
65 amino acids from heme to end
71% to 4E2 (very short match), 64% to 4D2,
96% to CYP4BN12v2, 2 aa diffs
72% to CYP4BN1, 45% to 4D22, 51% to XM_967484
70% to XM_967484.1 PREDICTED: Tribolium castaneum 42% to 4D14
CYP4BN12v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD1553
62 amino acids from heme to end
68% to 4E2 short match, 61% to 4D2,
69% to 4BN1, 67% to CYP4BN13v1
CYP4BN13v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD25180
64 amino acids from heme to end
57% to 4D2, 71% to 4BN3
71% to XM_961765.1 PREDICTED: Tribolium castaneum,
44% to 4D22, 47% to 4D23
56% to XM_966761.1, 52% to XM_967484
CYP4BN13v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD24810
61 amino acids from heme to end
54% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 68% to 4BN3
CYP4BN13v3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD29346
60 amino acids from heme to end
56% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 71% to 4BN3
CYP4BN13v4 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD61109
53 amino acids from heme to end
52% to 4D2, 96% to CYP4BN13v1, 69% to 4BN3
same aa seq as CYP4BN13v3, different nucleotide seq
CYP4BN14v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4D215Ic4
61 amino acids from heme to end
63% to 4D2, 64% to 4BN1 98% to CYP4BN14v2, 1 aa diff
CYP4BN14v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD273ic4
61 amino acids from heme to end
61% to 4D2, 62% to 4BN1
CYP4BP1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
46% to CYP4BM1 Tribolium castaneum
clone name EST MPB4B04
CYP4BQ1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
50% to 4AY1 full seq Ips paraconfusus
clone name EST DPG20G05
CYP4BR1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966411, XP_975718 (missing an exon)
AAJJ01002884.1
53% to 4BR3, 45% to 4H11, 43% to 4D23,
6659 MILAIVIALISAPFIWWMLILSKYRSLSNVPGPKPSPVIGNSLHIGYRPQDLFNNIVKWAKEYGTVYKIF
VANDVRVLITNPELTELVLSSNVHITKSNAYDLLKPWLGIGLLIST GKKWKSRRKLITPTFHFKILDQFL
DVFNSCGNVLVQRLSSQVGKDSFDVYPFINLCSLDIIC ETSMGVKIKAQQGNNTEYVEAVRRFLDIFIIR
TFSVWKGIDALFKFSSAYSVYKRLLKILHQFTINIIVQRRGEKAQQKTQNVTSDDGIKRKVALLEMLLES
EDNNMLSNEDIREEIDTFMFEGHDT TTSGIAFAILCLAENPKVQEKLYEEVVAVIDNIENITMQQLQEMK
YLEMVLKEAQRLYPSV PVIERRLEVDCNIGGYDFPKDTFLSLFIYGMHHNEKYFPEPEKFDPNRYLPENQ
AKRHNYAYVPFSAGPRNCIGQKFAMLEMKTTIAKIVKHFKILPVPDYKPDLGIAAILKSYNGVCVRLQHR
HGN 8527
CYP4BR2P Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01002884 pseudogene between 4BR1 and 4BR3
9437 SGKKWKTRRKMITPTFHFKILDQFIEVFNSCGNVLVEKLSSHVGKESVDVYPFINLCS 9610
9699 TKRNGIKRKVAXXX
9737 MLLESEHNNVLSNEDIREEIDNFMIRG
9823 HDTTAFGIAFAILALADN
9876 PKVQDKVYGEILSVIGDYEDVTMQ*LQDSRYLEMVIKEA 9992
GGYDFPKDTAFSTFXXXXXXXXXX 10083
10082 FPNPEKFDPNIFLPENQS 10135
CYP4BR3 Tribolium castaneum (red flour beetle)
GenEMBL XP_967724
53% to CYP4BR1
MFVVAFFVTLTVILCTPLIWWYLTLAKYSSLKKVPGPPPLPVIGNSNVIGKTTVDLLHSFMNLQDKYGTV
VKVWLGPRLHLLITKPEMVEFFLNSTVHLNKSDGYDLFKPWLGDGLLVSTGSKWKTRRKLITPTFHFKIL
ENFLETSFNKQINILLDVLLKEASQTDKSIEIHSLINLCSLDIICETAFGTELNAQAKCNPKYVEAVTGF
LEIFTLRFFSAWLRHPLIFRLSDKYAKYMEYLKILHDFTNTIIKRRKEEFKLLQDNAKISEEGIKRRAAL
LDMLLEVSDNGKNLTDEDIREEVDTFMFEGHDTTTTSICFVLYAIAQNPDVQKKIYDELVSVLGPDCKKE
ITFSDIQELKYLDVVIKEAHRLYPPVPLIERSLEEDCTIDGLTIPKNTNISIFLYGMNYNKDVYPEPHVF
DPDRFLPEKQGERHTFAYVPFSAGPRNCIGQKFALLELKTTIAKLLRCFEISPDPKNPPQVGMCSVLKSR
NGIHMFLKKKN
CYP4BS1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-2, 49% to 4C1 cockroach, 79% to CYP4BS2
Pediculus genome site
CYP4BS2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-3, 48% to 4C1 cockroach, 79% to CYP4BS1
Pediculus genome site
CYP4BS3 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-4i, 71% to CYP4BS1
Pediculus genome site
CYP4BT1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-5, 42% to CYP4C3
Pediculus genome site
CYP4BU1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-6, 42% to 4C1 cockroach, 52% to CYP4BU2
Pediculus genome site
CYP4BU2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-7, 52% to CYP4BU1, 38% to CYP4C1, 39% to 4AZ1 Apis
Pediculus genome site
CYP4BV1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-8, 41% to CYP4C3
Pediculus genome site
CYP4BW1 Ceratosolen solmsi martchali (fig wasp)
No accesion number
Dong-Guang Wan
Submitted to nomenclature committee July 9, 2007
54% to CYP4C25, 56% to CYP4C24 Orconectes limosus (crayfish)
partial seq from I-helix to heme
CYP4BW2 Ceratosolen solmsi martchali (fig wasp)
No accesion number
Dong-Guang Wan
Submitted to nomenclature committee July 9, 2007
95% to CYP4BW1, 55% to CYP4C24 Orconectes limosus (crayfish)
CYP4BW3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BW4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BW5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BX1 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BX2 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BX3 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BX4 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY1 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY2 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY3 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY4 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY5v1 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BY5v2 Daphnia pulex (Daphnia, water flea)
BQ703375 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.1 149 aa
58% to 4v3 mouse 59% to 4c24 66% to 4AN2
formerly CYP4AN3
renamed based on genomic full seq
CYP4BY6 Daphnia pulex (Daphnia, water flea)
Confidential
CYP4BZ1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BZ2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4CA1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4CB1 Liposcelis bostrychophila (psocid)
EU979550
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
36% to CYP4C3 Droso., 37% to CYP4C37, 38% TO 4C61, 37% TO 4C62
40% TO EU979551, 41% TO EU979549, 37% TO 4BM1 Tribolium
MLGLLILLVIIFALVIGLDYYNHYKDPRRIIDRIFPGPFRIPIVGNALIAACSREAFYRVYLNLSKSYDYKPFRLWFLKQPYVFISDYENTKKILSSNDLLDKAEDYRYFEPWLGQGLLTSKGDKWRRDRKIITPAFHFQILHRFFQIFYDNGEIFCEKLTAHDGGDVFDVFEYIEMLTLDNLCNAALKLDIQAQLNPFSALVCAIQNMGVVIYNRIFTLWLRYDAMFRLSSTARLQKKCLEIIHGNDVKIIRERKEEMKTKQPKLKTMEFDEKEKVAFLDLLLEMQDDVGYTDEDIREQLDTFMFAGHDTVTATLGFLIYSLAEHPDVQEKVYRELLDIYGESERCPNFSDLQDMKYTEQVIKETLRLYTVVTAVARRVEEDFELSEHQVVPKGVEIVLLLSALHRNPEIFPNPDIFDPDRFSPEVNQERDSFAFVPFSAGSRNCIGQKFAMHEMKITVYKIVKKFKLSISDKPEDKVRTRTGVVLSSTNGIRIKVQSRKKKTPSKLADQ
CYP4CC1 Liposcelis bostrychophila (psocid)
EU979549
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
39% to CYP4D22, 43% to CYP4D2, 40% TO 4C62, 39% TO CYP4C61
44% TO CYP4CD1, 41% TO CYP4CB1, 41% TO CYP4BN1 TRIBOLIUM
MIFYVIVTTILLLLYIKYRLTIRHLVVVDTMFPGPTCLPIIGNALMLRGTSEDFYKRFTETCFYYRRSFRVWIAHRLFIACLYPEDAEVILGNNFEITKADVYEFLLPWIGDGLITSTGKKWRTHRKMLTPAFHFRILEEFTKVFNKNGKIFCEVLSKIPENKIFDVYEYVKMYAMDNICETAMSVSINAQKNPNSAYIRAVKDMCTVAFKRMRTLWLRSDFLFRMSPWAKVHDDALSLIHSQTRDVIKKRKQELERNPDLRLTMENDNFSIKGKLAFLDILLHAAQEYRLTDEDIREEVDTFMFEGHDTITSAISFAMYYISRDQEVQKKILQETESIFRGEDREPTVKDFGAMKYLETVIKETLRLHPSVPFIARKISQDFQIDMKAYAPRGAEVLVVIAALHRNPYQWEKWDQFYPEHFLPEATQKRHPYSFVPFSAGPRNCIGQKFAMIEMKSVLSKVVKEFELIPSPHPEHAIREVPDLILTSGTGMHVGLRKRISGAA
CYP4CD1 Liposcelis bostrychophila (psocid)
EU979551
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
47% TO CYP4BN6 TRIBOLIUM,
42% to 4D17, 43% to 4D2, 41% to CYP4C62, 39% to 4C61
44% TO CYP4CC1, 40% TO CYP4CB1
MVLHGLFVTFVCATLIYVLERIIHRRVYKAEKQFDGPPGYWFFGNSFDFINKSSKEIFDQVVENLKTYGNGRFYKIRIMHRLGIACSDHRDMEVILGSNTLIDKGVHYHFILPWIGFGPLTSNGSRWRKHRKIITPTFHFKILEQFIDVFNKNGAIMCEKMEKEVNGEPFNVYNYVNLAALDNIFESAMGINMNVQKNSETTYVRAIKEMCNVVNKRVFWWILRIYPIFRLSKYYKMQTDALNVLHSTTVNIIEQRKKELAVRKKLEKDDEKDEEIEFYQKKRMAFLDLLLESAEASNISDEDIRQEVDTFMFEGHDTISSGLSFALWALANNPDVQQKVYEEQMEIFGDSNRPPTFNDLQNMKYLERTLKESQRLFPSVPMITRKLNEDVDLPGGYHLPKGTNVGMIIYSLHRDPKVWPNPEKFDPDNFTPDAIQGRNPYSYVPFSAGPRNCIGQKFAMLEMKSTVSKVVRQYKLLPSPYEKHKLQLTSELVLMSLSGVHVKIQRRSNSFS
CYP4CE1 Nilaparvata lugens (Homoptera: Delphacidae)
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: BPH4-8
38% to CYP4AZ1 honeybee, 42% to Cyp4c3 Drosophila
43% to Nilaparvata lugens CYP4C61, 41% to Nilaparvata lugens CYP4C62
CYP4CF1 Panonychus citri (citrus red mite)
FJ480404
47% to CYP4V2 human
CYP4CG1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4CG2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4CG3 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4FA1 Coscinasterias muricata Australian sea star (11 armed starfish)
GenEMBL AF163824
Georgiades,E., Holdway,D., Wu,Q.K., Brennan,S., Butty,J. and
Temara,A.
The impact of oil-derived products on the biology of the
eleven-armed asteroid Coscinasterias muricata
Aquatic Toxicol. (1999) In press
partial seq. from I-helix to heme
Given its own subfamily renamed CYP4FA1
Old name CYP4F20
CYP4FA1 Coscinasterias muricata Australian sea star (11 armed starfish)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
3 aa differences with AF163824 from I-helix to heme region
partial seq. from I-helix to heme
CYP4 Caenorhabditis elegans (nematode worm)
CEMSH91R
C-terminal fragment with coding region identical to wEST00713
CYP4 fragment. Region before translated "AGPRNCIG" may be an
intron sequence.
The complete gene of this fragment is CYP29A2, probably a 4 family
equivalent in C. elegans.
5A Subfamily
CYP5A1 rat
GenEMBL D28773
Tone,Y. et al.
unpublished
submitted to Nomenclature Committee
CYP5A1 rat
GenEMBL S69335 (1849bp)
Tone,Y., Miyata,A., Hara,S., Yukawa,S. and Tanabe,T.
Abundant expression of thromboxane synthase in rat macrophages
FEBS Lett. 340, 241-244 (1994)
Cyp5a1 mouse
GenEMBL L18868 (1856bp) Swiss P36423 (533 amino acids) AC073390.1
PIR JN0683 (533 amino acids)
Zhang,L., Chase,M.B. and Shen,R.-F.
Molecular cloning and expression of murine thromboxane synthase.
Biochem. Biophys. Res. Commun. 194, 741-748 (1993)
Note: ExxR sequence in K-helix is ETLS. The S deviates from an
extremely highly conserved R at this position.
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGI
RHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVE
NFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACE
LLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRAST
FCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRR
DFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQ
AFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPY
LDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPET
FDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPET
QVPLQLESKSALGPKNGVYIKIVSR
Cyp5a1 mouse
GenEMBL U41326 to U41337 and U41397 (genomic sequences)
Zhang,L. and Shen,R.-F.
unpublished (1996)
CYP5A1 Sus scrofa (pig)
GenEMBL L13128 (1789bp)
Shen,R.-F., Zhang,L., Baek,S.-J., Tai,H.-H. and Lee,K.-d.
Porcine thromboxane synthase complementary DNA: cloning,
expression, and sequence comparison.
Gene 140, 261-265 (1994)
CYP5A1 human
GenEMBL M74055 (687bp) PIR JN0074 (245 amino acids)
Wang,L.-H., Oshashi,K. and Wu,K.K.
Isolation of partial complementary DNA encoding human thromboxane
synthase
Biochem. Biophys. Res. Commun. 177, 286-291 (1991)
CYP5A1 human
GenEMBL M80646 (1719bp) M80647 (1882bp)
PIR A41766 (534 amino acids)
Ohashi,K., Ruan,K.-H., Kulmacz,R.J., Wu,K.K. and Wang,L.-H.
Primary structure of human thromboxane synthase determined from
the cDNA sequence.
J. Biol. Chem. 267, 789-793 (1992)
M08646 is truncated M08647 is functional.
CYP5A1 human
GenEMBL S70152 (1753bp)
Lee,K.-d., Baek,S.-J. and Shen,R.-F.
Cloning and characterization of the human thromboxane synthase
gene promoter.
Biochem. Biophys. Res. Commun. 201, 379-387.
exon 1 and promoter
CYP5A1 human
GenEMBL S51388 (1910bp)
Yokoyama,C., Miyata,A., Ihara,H., Ullrich,V. and Tanabe,T.
Molecular cloning of human platelet thromboxane A synthase.
Biochem. Biophys. Res. Commun. 178, 1479-1484 (1991)
CYP5A1 human
GenEMBL D34614 to D34625
Miyata,A., Yokoyama,C., Ihara,H., Bandoh,S., Takeda,O.,
Takahashi,E.-I. and Tanabe,T.
Characterization of the human gene (TBXAS1) encoding thromboxane
synthase
Eur. J. Biochem. 224, 273-279 (1994)
CYP5A1 Bos taurus (cow)
See cattle page for details
94 MEVLGLFRLEVSGPMVTVALSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQ 276
277 GFWESHMELRKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEKFSNFTNRMAT 432
433 GLEPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERH 600
601 AQSGEAFDIQKTYCCYTTDVVASVAFGTEVNSQEAPEHPF 720
VEHCRRFFASSIPKPLLVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQ
AAEERRRDFLQMVQDVRHSAATVGVENFDIVRQVFSATKCPANPPRRHSPRPLSKP
1069 LSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCS 1248
1249 LQEGLPYLDMVIKETLRMYPPAFRFTRVAAQDCEVLGQRIPAGAVLETAVGALHYDPE 1422
1423 HWPNPENFNPERFTAEAQQRRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFR 1596
1597 FEACPETQVPLQLESKSALGPKNGVYIRIVSR*
CYP5A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
82% to human 5A1, one aa diff to NM_214046.1
Ortholog of human CYP5A1
CYP5A1 Sus scrofa (pig)
NM_214046.1
82% to human 5A1
MEVLGFLSPELNGPMVTMALAVVLLALLKWYSTSAFSRLEKLGI
RHPKPSPFIGNLTFFRQGFWESHMELRKQYGPLSGYYLGRRMIVVISDPDMIKQVLAE
KFSNFTNRMATGLESKPVADSILFLRDKRWEEVRSVLTSAFSPKKLNKLTPLISQACD
LLLAHLERYAESGDAFDIQRCYCCYTTDVVASVAFGTQVNSSEEPEHPFVKHCRRFFA
FSVPRLILVLILSFPSIMVPLARILPNKKRDEVNGFFNKLIRNVIALRDQQAAEERRQ
DFLQMVLDLRHSAPSVGVENFDIVRQAFSSAKGCPADPSQPHLPRPLSKPLTVDEVVG
QAFLFLIAGYEIITNTLSFVTYLLATNPDCQEKLLREVDDFSKKHPSPEHCSLQQGLP
YLDMVLSETLRMYPPAFRFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHWPHPE
TFDPERFTAEAQRLQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPE
TQVPLQLESKSALSPKNGVYIRIVPR
CYP5A1 Xenopus laevis
See Xenopus pages for seq
CYP5A1 Xenopus tropicalis
See Xenopus pages for seq
CYP5A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP5A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_1244
49% to 5A1 human
7486 MSQLIFNIKFLEVTIRLSVNTVLSFRYSVRPFSVLSRNGIKHPKPLPFFGNLFMFRQ 7316 (0)
7158 GFFNPLNDLIKTHGRVCG 7105 (2)
7021 YYLGRKPVVVVADPEMLRQVMVKDFSSFPNRM 6926 (0)
6848 SLRFITKPMSDCLLMLRNERWKRVRSILTPAFSASKMKE 6732 (0)
6519 MVPLINTATDALIKNLDAFAESAEAFNIHK 6430 (2)
6355 CFGCFTMDVVASVAFGTQVDSQNNCDDPFVRHAQLFFSFNFFRPIMLFF 6209 (1)
6046 AAFPSLAAPLVGIIPNKKRDDMNHFFIRTIQKIIKQREEQPPEQ 5915 (0)
5794 RRRDFLQLMLDARTSDESVSIEHFDTAHPVGEAHNRSEQNQDNQVGPQERPQMKM 5630
5629 ITEDEIVGQAFVFLVAGYETSSNTLAFACYLLAINPECQRELQKEVDHFFTRH 5471 (0)
5395 ESPDYTNVQELKYLDMVISETLRLYPPGFR 5306 (2)
5229 FAREIERDCVVNGQSFPKGATFEIPAGFLHRDPEHWPDPDKFIPER (2)
4998 FTPEAKASRHPFVYIPFGAGPRNCVGMRLAQLEMKMALVRLFRRFNLLACTETK 4837 (0)
4699 VPLELKSSSTLGPKNGVFVKIERRHWDESQVNSPSED* 4586
6A Subfamily
CYP6A1 Musca domestica (house fly)
GenEMBL L27241 (1982bp) L27242 (3888bp)
Cohen,M.B., Koener,J.F. and Feyereisen,R.
Structure and chromosomal localization of CYP6A1, a cytochrome
P450-encoding gene from the house fly.
Gene 146, 267-272 (1994)
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL S51248 (1689bp) M88009 (2848bp)
GenEMBL S36482 S36608 (cross-reference numbers from SwissProt
but they do not match any sequences in Genbank)
Swiss P33270 (507 amino acids) PIR A45378 A47198 (507 amino acids)
Waters,L.C., Zelhof,A.C., Shaw,B.J. and Ch'ang,L.-Y.
Possible involvement of the LTR of transposable element
17.6 in regulating expression of an insecticide resistance
associated P450 gene in Drosophila.
Proc. Natl. Acad. Sci. USA 89, 4855-4859 (1992)
correction: PNAS 89, 12209, (1992)
Note: This is P450-B1, the sister sequence P450-A1 is CYP4G1.
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL U78088(5737bp)
Dunkov, B.C., Guzov, V.M., Mocelin, F., Shotkoski, F., Brun, A.,
Amichot, R., ffrench-Constant, R.H. and Feyereisen,R.
The Drosophila melanogaster gene Cyp6a2: Structure, localization,
heterologous expression and induction by phenobarbital.
submitted (1996)
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL AC007549 comp(100072-101661)
Cyp6a2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6A3 Musca domestica (housefly)
GenEMBL U09231 (2142bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A4 Musca domestica (housefly)
GenEMBL U09232 (2089bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A5v1 Musca domestica (housefly)
GenEMBL U09343 (2110bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A5v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #10-3
7 aa diffs to 6A5v1
CYP6A6 Musca domestica (housefly)
GenEMBL U09344 (718bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A7 Musca domestica (housefly)
Rene Feyereisen
Submitted to nomenclature committee
Cyp6a8 Drosophila melanogaster
GenEMBL L46859(1595bp) AC020447 comp(122688-124264)
Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
Organization and expression of new cytochrome P450 (Cyp) genes of
Drosophila melanogaster.
Unpublished (1995)
Cyp6a8 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a9 Drosophila melanogaster
GenEMBL L46860(1591bp) AC020447 comp(115043-116610)
Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
Organization and expression of new cytochrome P450 (Cyp) genes of
Drosophila melanogaster.
Unpublished (1995)
CYP6A10 Ceratitis capitata (Mediterranean fruit fly)
GenEMBL U78795(1720bp)
Danielson,P.B., Foster,J.L.M., Cole,S.K. and Fogleman,J.C.
unpublished (1996)
CYP6A11 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD154 PCR of C-terminal
CYP6A12 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD47 PCR of C-terminal
Cyp6a13 Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region 44D1-
44D2, DS08616, complete sequence [Drosophila melanogaster]
4-474 comp(7564-8986) 52% identical to CYP6A5
Cyp6a13 Drosophila melanogaster
GenEMBL AC020451 3757-5238 also AC007085 126189-124714 no introns
MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIY
RKFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFL
DGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVI
GSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVS
EFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTS
STTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPI
LPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKAR
HPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQ
EGVHLRMEGLERP
Cyp6a13 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a14 Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R,
region 44D1-44D2, 2-474 13565-15095 57% identical to CYP6A5
Cyp6a14 Drosophila melanogaster
GenEMBL AC007085 33266-34850
MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIY
KKFKGQGPIAGMYTFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFAL
EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCA
RFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIK
VLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTL
EQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVL
AQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIY
PEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS
NRTDVPLIFSKKSFLLTTNDGIYLKVERV
Cyp6a14 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a15p Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region
44D1-44D2, mid to heme comp(10139-9361) POSSIBLE PSEUDOGENE
(MISSING N-TERMINAL)
Cyp6a15p Drosophila melanogaster
GenEMBL AC020451 2595-3373 with in frame stops and frame shifts
AFTVTNSKLAKKLKMKILRDDLTDFFLSVVKPALSGMTLWTSPPSGGRSSRQGGSKFDLS
HNWTLEQMAAQAIVFFLAGFETSSSTMSSCKYELALQPEI*NQIRDEIERVLEGNAITYD
ALAKINYPEQVLSETLRKHPIQLIKFLLETQESFRVRNTELIVEKGTSLLIPVHSVHYDP
HLYPHPKLFDSSRLKAYKSNSRHPFAYLPFGTFGPRSCIGLRFGKMQAKIGIVSLCQRFK
FGDSDLTDIPL
Cyp6a16p Drosophila melanogaster
GenEMBL AC004721 comp(2956-5070)
47% to 6a8
1 exta A nucleotide after MDLLLDLRR causes a frameshift
Cyp6a16 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a17 Drosophila melanogaster
GenEMBL AC020447 109264-110826 complete
AL052842 assembled from fragments only
AL074108 AA699131 AI135898 AI260230 AI258456
AI534145 AI114010 AI533952 AI402220
49% with 6a2
Cyp6a17 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a18 Drosophila melanogaster
GenEMBL AC008285 85740-87319 AI403838
Cyp6a19 Drosophila melanogaster
GenEMBL AC020447 113084-114646
Cyp6a20 Drosophila melanogaster
GenEMBL AC020447 117416-119045
Cyp6a20 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a21 Drosophila melanogaster
GenEMBL AC020447 comp(120585-122149)
Cyp6a21 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a22 Drosophila melanogaster
GenEMBL L46858 AC020447 106987-108653
Ranjan Ganguly
Cyp6a22 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a23 Drosophila melanogaster
GenEMBL AC020447 111145-112718
Cyp6a23 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6A24 Musca domestica (housefly)
No accession number
Eriko Kamiya
Submitted to nomenclature committee 1/8/2000
62% to CYP6A1
CYP6A25 Musca domestica (housefly)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Feb. 20, 2000
Clone name TA14-1
Cyp6a26 Drosophila simulans
No accession number
Sophie Tares-Amichot
Submitted to nomenclature committee Sept. 29, 2000
96% to Cyp6a2, probable ortholog to 6a2
CYP6A27 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised June 27, 2005 to full length
Clone name Lc_CYP6A8
61% to 6A9 64% to 6A32
CYP6A28 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised June 27, 2005 to full length
Clone name Lc_CYP6A2
52% to 6A9 63% to 6A1 and 6A24
CYP6A29 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A7
50% to 6A9 63% to 6A28 (307 aa)
CYP6A30 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A1
59% to 6A16 (308 aa)
CYP6A31 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A3
60% to 6A14 (355 aa)
CYP6A32 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A4
58% to 6A9 64% to 6A27 (347 aa)
CYP6A33 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A5
51% to 6A16 78% to 6A34 60% to 6A30 (309 aa)
CYP6A34 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A6
49% to 6A16 78% to 6A33 (309 aa)
CYP6A35 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A9
60% to 6A9 (262 aa)
CYP6A36 Musca domestica (house fly)
No accession number
Nannan Liu
59% identical to 6a21, 61% to 6A27, 58% to 6A37
clone #15
submitted to nomenclature committee 4/10/06
CYP6A37 Musca domestica (house fly)
No accession number
Nannan Liu
66% to 6A9, 67% to 6A7 first 334 aa
clone #15prime
submitted to nomenclature committee 4/10/06
CYP6A38v1 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #17
ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS TO 6A38v2
98% to AB050019.1 Musca domestica CYP6A24 (7 aa diffs)
12 aa diffs to 6A39
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A38v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #16-2
ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS TO 6A38v1
96% (16 aa diffs to 6A39)
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A39 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #16-8
49% to 6A2, 12 aa diffs to 6A38v1
16 diffs plus two frameshifts to 6A38v2
97% to AB050019.1 13 aa diffs TO 6A24
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A40 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
top 19 BLAST hits are all CYP6A sequences
52% to Cyp6a9 D. melanogaster
47% to CYP6A1 Musca domestica
47% to Cyp6a2 D. melanogaster
43% to CYP6A3 Musca domestica
44% to CYP6A4 Musca domestica
44% to CYP6A5 Musca domestica
46% to CYP6A6 Musca domestica (partial seq)
49% to CYP6A7 Musca domestica (partial seq)
45% to CYP6A24 Musca domestica
50% to CYP6A25 Musca domestica (partial seq)
49% to CYP6A36 Musca domestica
51% to CYP6A37 Musca domestica
45% to CYP6A38v1 Musca domestica
45% to CYP6A39 Musca domestica
sequence # 1
6B Subfamily
CYP6B1 Papilio polyxenes (black swallowtail butterfly)
GenEMBL S48952 M80828 (1623bp) M83117 (1608bp)
Swiss Q04552 Q04553 (498 amino acids) PIR A46367 (498 amino acids)
Cohen,M.B., Schuler,M.A. and Berenbaum,M.R.
A host-inducible cytochrome P450 from a host specific
caterpillar: molecular cloning and evolution.
Proc. Natl. Acad. Sci. USA 89, 10920-10924 (1992)
Note: have not been able to download S48952 from GCG or NCBI.
CYP6B1 Papilio polyxenes (black swallowtail butterfly)
GenEMBL Z29624 (3191bp)
Prapaipong,H.H., Berenbaum,M.M. and Schuler,M.M.
Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
Nuc. Acids Res. 22, 3210-3217 (1994)
CYP6B1v3 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U05037 (3191BP)
Prapaipong,H. Berenbaum,M.R., Schuler,M.A.
Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
unpublished (1994)
CYP6B1v1/v2Papilio polyxenes (black swallowtail butterfly)
no accession number
Ma, R., Cohen,M.B., Berenbaum,M.R. and Schuler,M.A.
Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that
selectively metabolize linear furanocoumarins.
Arch. Biochem. Biophys. 310, 332-340 (1994)
CYP6B2/CYP6B6 chimera Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U18085 (1995bp)
Wang,X. and Hobbs,A.A.
Isolation and Sequence Analysis of a cDNA clone for a Pyrethroid
Inducible Cytochrome P450 from Helicoverpa armigera.
Unpublished (1995)
Note: this sequence is reported to be a chimera of 6B2 and 6B6
The first 90 aa do not seem to belong to 6B2
Pers. Comm. David G. Heckel
The N-term seq of U18085 is very similar to 6B6, 6B9 and 6B27
With 3-4 amino acid differences.
CYP6B2v1 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ017a-v1Pep
59% to 6B29 96% to 6B2 18 aa diffs in first 90aa
only 2 aa diffs after that. (alternative splicing?)
CYP6B2v2 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ017b-v2Pep
58% to 6B29 2aa diffs to CYP6B2v2
CYP6B2v3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000107 4 aa diffs to Ha-12E11-C (R. Feyereisen)
in a CYP6B gene cluster
11 aa diffs to CYP6B2v1
The related sequence HAH013651 has 4 aa diffs to HAH000107
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B6v1 Helicoverpa armigera (Australian cotton bollworm)
U64800
Note: this gene cluster has at least 5 genes
CYP6B7, 6B6, 6B2 and two more
There is high polymorphism and the
haplotypes are being examined in more detail
CYP6B6v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_187 99% to 6B6v1 U64800, 4 aa diffs
in a CYP6B gene cluster
The related sequence Contig_271 has 3 aa diffs to Contig_187
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B3 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U25819 (1599bp)
Hung,C.-F., Harrison,T.L., Berenbaum,M.R. and Schuler,M.A.
CYP6B3-A Second Furanocoumarin-inducible Cytochrome P450 Expressed
in Papilio polyxenes
Insect Biochem. and Mol. Biol. (1995) In press
CYP6B3v2 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U65488(2978bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification
unpublished (1996)
CYP6B4 Papilio glaucus (butterfly)
GenEMBL U47059(1619bp)
Hung,C.F., Berenbaum,M.R. and Schuler,M.A.
Isolation and characterization of a furanocoumarin-inducible
cytochrome P450 cDNA from a polyphagous lepidopteran.
unpublished (1996)
cDNA slight difference with both genomic sequences
CYP6B4v1 Papilio glaucus (butterfly)
GenEMBL U65490(2957bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification.
unpublished (1996)
CYP6B4v2 Papilio glaucus (butterfly)
GenEMBL U65489(4279bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification.
unpublished (1996)
CYP6B5 Papilio glaucus (butterfly)
Hung,C.-F. and Schuler,M.
no accession number
genomic DNA missing last 24 amino acids
1 aa difference from B4v2, both B4v2 and B5 on one piece of DNA
submitted to Nomenclature Committee
CYP6B6 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U64800(1936bp)
Ranasinghe,C. and Hobbs,A.A.
A member of the cytochrome P450 family CYP6B from Helicoverpa
armigera.
unpublished (1996)
CYP6B6 Helicoverpa armigera (Australian cotton bollworm)
Note: this gene cluster has at least 5 genes
CYP6B7, 6B6, 6B2 and two more
There is high polymorphism and the
haplotypes are being examined in more detail
CYP6B7 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL AF031468 (2411bp)
Ranasinghe,C. and Hobbs,A.A.
Complete cDNA sequence for Cytochrome P450 CYP6B7 from Helicoverpa
armigera (Cotton Bollworm)
Unpublished
CYP6B7 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
1 aa diff.
CYP6B8v1 Helicoverpa zea
GemEMBL AF102263
Li,X.C., Berenbaum,M.R. and Schuler,M.A.
Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible
cytochrome P450 cDNA from Helicoverpa zea
Insect Biochem. Mol. Biol. 30, 75-84 2000
submitted to nomenclature committee 10/27/98
99% identical to 6B7 (this is the orthologous gene to 6B7)
CYP6B8v2 Helicoverpa Zea
GenEMBL AF285828
Xianchun Li
Clone name: P6
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v3 Helicoverpa Zea
GenEMBL AF285829
Xianchun Li
Clone name: P12
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v4 Helicoverpa Zea
GenEMBL AF285830
Xianchun Li
Clone name: P15
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v5 Helicoverpa Zea
GenEMBL AF285186
Xianchun Li
Clone name: P23
Intron sequence differs from 6B8 by 229 bp insertion otherwise very
similar to 6B8
Submitted to nomenclature committee June 14, 2000
formerly CYP6B28 but now an allele of CYP6B8
CYP6B8v6 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_208 99% to 6B8v1 (2 aa diffs)
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B9 Helicoverpa zea
no accession number
Satish Pimprale
submitted to nomenclature committee 10/6/98
most like CYP6B6 (95% identity) 90% with 6B2, 86% with 6B7
and 87% with 6B8
CYP6B10 Heliothis virescens
no accession number
Satish Pimprale
submitted to nomenclature committee 10/6/98
most like CYP6B6 (92% identity) 86% with 6B2, 6B7 and 6B8
CYP6B11 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F2
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B12 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F47
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B13 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-C1
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B14 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-P46
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B15 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-P47
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B16 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F28
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B17 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
IN-G1
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B18 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F54
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B19 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F17
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B20 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F61
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B21 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F46
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B22 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F8
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B23 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-X9
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B24 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-X43
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B25 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-X21
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B26 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-X22
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B27 Helicoverpa Zea
GenEMBL AF285831
Xianchun Li
Clone name: 6B6G13R4
Intron sequence differs from 6B9
Submitted to nomenclature committee June 14, 2000
CYP6B28X Helicoverpa Zea
GenEMBL AF285186
Xianchun Li
Clone name: P23
Intron sequence differs from 6B8 by 229 bp insertion otherwise very
similar to 6B8
Submitted to nomenclature committee June 14, 2000
Renamed CYP6B8v5 an allele of CYP6B8
CYP6B29 Bombyx mori (silkworm)
BAAB01105883.1 BAAB01064450.1
51% TO 6B1
See silkworm page for sequence
CYP6B29 Bombyx mori (silkworm)
GenEMBL DQ252324
Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H.,
Li,B., Gong,C.L. and Shen,W.D.
Only 8 differences to 6B29 Bombyx mori genomic seqs
Since one of the genomic diffs is a stop codon
This mRNA seq is probably the more accurate seq
CYP6B29 Bombyx mandarina (wild silkworm)
GenEMBL DQ252325
Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H.,
Li,B., Gong,C.L. and Shen,W.D.
Only 4 differences to 6B29 Bombyx mori genomic seqs
CYP6B30 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
Submitted to nomenclature committee Jan. 13, 2004
94% to CYP6B25
CYP6B31 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee Jan. 27, 2005
74% to 6B2
CYP6B32 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
2 aa diffs to PMC5-8, 3 aa diffs to PMC7-13,
3 aa diffs to PMC5-15, 6 aa diffs to PMC6-15, 7 aa diffs to PMC6-13
91% to 6B30
clone name PMC5-4
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B33 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
1 aa diff to PMC5-15 , 2 aa diffs to PMC5-4, 91% to 6B30
clone name PMC5-8
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B34 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
1 aa diff to PMC5-8, 91% to 6B30
clone name PMC5-15
note: 6B32-6B37 came from a single larvae, so there cannot be six alleles of a
single gene in one larvae. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B35 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
6 aa diffs to PMC7-13, 90% to CYP6B30
clone name PMC6-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B36 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
6 aa diffs to PMC5-4, 91% to CYP6B30
clone name PMC6-15
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B37 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
3 aa diffs to PMC5-4, 91% to CYP6B30
clone name PMC7-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B38 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 6B39, 79% to 6B40, 75% to 6B42,
74% to CYP6B6 Helicoverpa armigera, 73% to CYP6B2v1, 73% to 6B27
CYP6B39 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 6B38, 79% to 6B40, 76% to 6B42,
74% to CYP6B6 Helicoverpa armigera
CYP6B40 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
79% to 6B38, 79% to 6B39,
74% to CYP6B6 Helicoverpa armigera, 73% to 6B2 Helicoverpa armigera
CYP6B41 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
73% to 6B39, 71% to 6B6
CYP6B42 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
76% to 6B6, 77% to 6B7
CYP6B43.a Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_157 54% to CYP6B2 N-term aa 1-164, might join with Contig_259
HAH005783 is 100% to Contig_157
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B43.b Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_259 37% to 6B27 aa 174-340 mid region,
HAH005621 is 100% to Contig_259
might join with Contig_157
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B44 Amyelois transitella (Navel orangeworm)
No accession number
Guodong Niu
submitted to nomenclature committee May 27, 2008
clone AL55-2
55% to CYP6B29
CYP6B45 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6B46 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6B47 Spodoptera litura (common cutworm)
No accession number
Jialiang Zhou
submitted to nomenclature committee July 28, 2009
84% to CYP6B39
CYP6B48 Spodoptera litura (common cutworm)
No accession number
Jialiang Zhou
submitted to nomenclature committee July 28, 2009
85% to CYP6B39, 94% to CYP6B47
6C Subfamily
CYP6C1 Musca domestica (housefly)
GenEMBL U09233 (2310bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6C2 Musca domestica (housefly)
GenEMBL U09345 (1801bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
6D Subfamily
CYP6D1 Musca domestica (housefly)
GenEMBL U15168 (1551bp)
Tomita,T. and Scott,J.G.
cDNA and deduced protein sequence of CYP6D1: the putative gene for
a cytochrome P450 responsible for pyrethroid resistance in the
house fly.
Insect Biochem. Molec. Biol. 25, 275-283 (1995)
Liu,N., Tomita,T. and Scott,J.G.
Allele-specific PCR reveals the CYP6D1 is on chromosome 1 in the
house fly, Musca domestica.
Unpublished (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22362(1551bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22366(1548bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22367(1551bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica strain LPR (house fly)
GenEMBL AF064794
Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
House fly cytochrome P450 CYP6D1: 5' flanking sequences and
comparison of two alleles
Unpublished
CYP6D1v1 allele, complete cds.
CYP6D1v2 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
CYP6D1v3 Musca domestica strain LPR (house fly)
GenEMBL AF064795
Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
House fly cytochrome P450 CYP6D1: 5' flanking sequences and
comparison of two alleles
Unpublished
CYP6D1v3 allele, complete cds.
CYP6D1v4 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
CYP6D1v5 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
Cyp6d2 Drosophila melanogaster
Berkeley Drosophila Genome Project P1 clone DS00837 subclone 2a10 (-)
strand
complete genomic sequence, 4 exons
Cyp6d2variant Drosophila melanogaster
Andrew Hobbs
exon 4 48/53 amino acids identical
submitted to Nomenclature Committee
Cyp6d2 Drosophila melanogaster
GenEMBL AC020206 comp(66328-68065) also AC008350
Cyp6d2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6D3v1 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee 10/28/99
79% identical to 6D1
CYP6D3v2 Musca domestica (housefly)
Eriko Kamiya
Submitted to nomenclature committee Sept. 17, 2000
98% identical to CYP6D3v1
Cyp6d4 Drosophila melanogaster
GenEMBL AC017250 37993-39657 also AC008197 AC009846
Cyp6d4 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6d5 Drosophila melanogaster
GenEMBL AC018176 comp(132649-134791)
Cyp6d5 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6D6 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6D1
62% to 6D2 70% to 6D3 (366 aa)
CYP6D7 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Sequence revised on Dec. 18, 2007
Original Clone name Lc_CYP6D2
New clone name Luce0098H18 (full length)
61% identical to Drosoph. CYP6d5
CYP6D8 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
56% to Cyp6d5 D. melanogaster
sequence # 3
6E Subfamily
CYP6E1 Culex quinquefasciatus Say (mosquito)
GenEMBL AB001323
Shinji Kasai
Culex-1
CYP6E1 Culex pipiens
6F Subfamily
CYP6F1 Culex quinquefasciatus Say (mosquito)
Shinji Kasai
Culex-2
submitted to Nomenclature Committee
CYP6F1 Culex pipiens
CYP6F2 Aedes aegypti (yellow fever mosquito)
CYP6F3 Aedes aegypti (yellow fever mosquito)
CYP6F4 Culex pipiens
CYP6F5P Culex pipiens
CYP6F6 Culex pipiens
Cyp6g1 Drosophila melanogaster
no accession number
Phil Danielson
Submitted to nomenclature committee 6/13/98
CS39
Cyp6g1 Drosophila melanogaster
GenEMBL AC015208 comp(21239-22935) also AC007440
Cyp6g1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6g2 Drosophila melanogaster
GenEMBL AC015208 19014-20624
Cyp6g2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6G3 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised to full length June 27, 2005
Clone name Lc_CYP6G
60% to 6G1
CYP6G4 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
60% to Cyp6g1 D. melanogaster
sequence # 2
CYP6H1 Locusta migratoria migratorioides
GenEMBL AF115777
Jochen Winter, Graeme Bilbe, Hanny Richener, Bernd Sehringer, Hartmut
Kayser
Cloning of a cDNA Encoding a Novel Cytochrome P450 from the Insect
Locusta migratoria: CYP6H1, a Putative Ecdysone 20-Hydroxylase
BBRC 259, 305-310 (1999)
Submitted to nomenclature committee 12/2/98
CYP6J1 Blattella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee 1/20/99
41% identical to 6H1
CYP6K1 Blatella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee 3/9/99
CYP6L1 Blatella germanica (German cockroach)
GenEMBL AF227531
Wen, Z. and Scott, J.G.
Cytochrome P450 CYP6L1 is specifically expressed in the
reproductive tissues of adult male German cockroaches, Blattella
germanica (L.)
Insect Biochem. Molec. Biol. 31: 179-187 (2001)
submitted to nomenclature committee 2/11/99
41% to CYP6H1, 35% to 6J1
CYP6M1 Anopheles gambiae
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene D
CYPm3r7 on chromosome 3
47% identical to CYP6A5
CYP6M1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r7
CYP6M1 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
81% to 6M1v2 probable ortholog, 66% to 6M2
CYP6M2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r9
CYP6M3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r10
CYP6M4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r11
CYP6M5 Aedes aegypti (yellow fever mosquito)
CYP6M5v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.4
CYP6M5v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.1
CYP6M6 Aedes aegypti (yellow fever mosquito)
CYP6M6 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1-1
CYP6M7 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 3, aa 316-440
89% to 6M3, 76% to 6M2
probable ortholog of 6M3
CYP6M8 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 4, aa 317-441
91% to 6M2, 80% to 6M3
probable ortholog of 6M2
CYP6M9 Aedes aegypti (yellow fever mosquito)
CYP6M10 Aedes aegypti (yellow fever mosquito)
CYP6M11 Aedes aegypti (yellow fever mosquito)
CYP6M12 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 6
83% to CYP6M6 Aedes
CYP6M12 Culex pipiens
CYP6M13 Culex pipiens
CYP6M14 Culex pipiens
CYP6M15 Culex pipiens
CYP6M16 Culex pipiens
CYP6N1 Anopheles gambiae
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 12D2
46% identical to CYP6E1
CYP6N1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r8
CYP6N2 Anopheles gambiae (formerly CYP6Q1)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene A
46% identical to CYP6A1 and 6E1 52% to 6N1
renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences
CYP6N2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r4
CYP6N2 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 4
89% identical to CYP6N2 Anopheles gambiae probable ortholog
CYP6N3v1 Aedes albopictus
GenEMBL AF283836 (still confidential on July 31 2000)
Zhou Guo-li
62% identical to CYP6N1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v2 Aedes albopictus
GenEMBL AF283837 (still confidential on July 31 2000)
Zhou Guo-li
3 diffs with CYP6N3v1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v3 Aedes albopictus
GenEMBL AF283838 (still confidential on July 31 2000)
Zhou Guo-li
4 diffs with CYP6N3v1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v4 Aedes albopictus
GenEMBL AF284783 (still confidential on July 31 2000)
Zhou Guo-li
2 diffs with CYP6N3v1 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v1 Aedes albopictus
GenEMBL AF284782 (still confidential on July 31 2000)
Zhou Guo-li
83% to CYP6N3v1 over partial sequence (missing heme-end)
60% to 6N1 and 60% to 6N2
submitted to nomenclature committee July 31, 2000
CYP6N4v2 Aedes albopictus
GenEMBL AF284784 (still confidential on July 31 2000)
Zhou Guo-li
3 diffs with CYP6N4v1 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v3 Aedes albopictus
GenEMBL AF284785 (still confidential on July 31 2000)
Zhou Guo-li
1 diff with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v4 Aedes albopictus
GenEMBL AF284786 (still confidential on July 31 2000)
Zhou Guo-li
5 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v5 Aedes albopictus
GenEMBL AF284787 (still confidential on July 31 2000)
Zhou Guo-li
4 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v6 Aedes albopictus
GenEMBL AF284788 (still confidential on July 31 2000)
Zhou Guo-li
6 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N5X Aedes aegypti (yellow fever mosquito)
Note: 6N5 is the same seq as CYP6N1
CYP6N6 Aedes aegypti (yellow fever mosquito)
CYP6N6v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1.4
CYP6N6v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I2.2
CYP6N7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427077.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 14
66% to CYP6N4v6, 65% to CYP6N3v1
partial seq, 84 aa EXXR to heme
CYP6N8 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427073.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone1-5
61% to CYP6N7
partial seq, 84 aa EXXR to heme
CYP6N9 Aedes aegypti (yellow fever mosquito)
CYP6N10P Aedes aegypti (yellow fever mosquito)
CYP6N11 Aedes aegypti (yellow fever mosquito)
CYP6N12 Aedes aegypti (yellow fever mosquito)
CYP6N13 Aedes aegypti (yellow fever mosquito)
CYP6N14 Aedes aegypti (yellow fever mosquito)
CYP6N15 Aedes aegypti (yellow fever mosquito)
CYP6N16 Aedes aegypti (yellow fever mosquito)
CYP6N17 Aedes aegypti (yellow fever mosquito)
CYP6N18 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 33
75% to 6N16 Aedes, 74% to 6N2 Anoph.
CYP6N18 Culex pipiens
CYP6N19 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 31
68% to 6N11 Aedes, 57% to 6N1v2 Anoph.
CYP6N19 Culex pipiens
CYP6N20 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 28
55% to 6N1v2 Anoph., 67% to 6N9 Aedes
CYP6N20v1 Culex pipiens
CYP6N20v2 Culex pipiens
CYP6N21P Culex pipiens
CYP6N22 Culex pipiens
CYP6N23 Culex pipiens
CYP6N24 Culex pipiens
CYP6N25 Culex pipiens
CYP6N26P Culex pipiens
CYP6N27P Culex pipiens
CYP6P1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 7G05
44% identical to CYP6A5
CYP6P1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r7
CYP6P1 Anopheles funestus
No accession number
Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson,
Lizette Koekemoer, on Sept. 9, 2004
82% identical to A. gambiae CYP6P1 I-helix to heme
this is the presumed ortholog to CYP6P1
other 6P sequences are much less similar
CYP6P2 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/31/02
clone name P2
61% identical to CYP6P1
CYP6P2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r8
CYP6P2 Anopheles funestus
No accession number
Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson,
Lizette Koekemoer, on Sept. 9, 2004
84% identical to A. gambiae CYP6P2 I-helix to heme
this is the presumed ortholog to CYP6P2
other 6P sequences are much less similar
CYP6P3 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/31/02
clone name 17d17
55% identical to CYP6P1
CYP6P3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r4
CYP6P4 Anopheles gambiae (mosquito)
no accession number
Dimitra Nikou
submitted to nomenclature committee 2/25/02
clone name 18M16
64% to 6P3 missing C-term
CYP6P4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r6
CYP6P4 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 3
89% identical to CYP6P4 Anopheles gambiae probable ortholog
CYP6P5 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
77% to 6P3
CYP6P5 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r5
CYP6P5 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 2
88% identical to CYP6P5 Anopheles gambiae probable ortholog
CYP6P6 Anopheles minimus
GenEMBL AY128947
This sequence was named incorrectly by the author as CYP6P5
but that was not an official name, so it has been changed.
84% to CYP6P3
CYP6P7 Anopheles minimus
No accession number
Rongnoparut, P.
Submitted to nomenclature committee October 17, 2003
Clone name minimus 1
81% to CYP6P2
CYP6P8 Anopheles minimus
No accession number
Rongnoparut, P.
Submitted to nomenclature committee October 17, 2003
Clone name minimus 2
79% to CYP6P1
CYP6P9 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 1, aa 327-451
86% to 6P3, 83% to 6P5
CYP6P9 Anopheles funestus
No accession number
Tonderayi Matambo, Lizette Koekemoer
submitted to nomenclature committee 12/13/07
complete seq
84% to 6P3
CYP6P10v1 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948075
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 1
65% to CYP6P4
CYP6P10v2 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948076
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 2
98.6% to CYP6P10v1
CYP6P10v3 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948077
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 3
98.4% to CYP6P10v2
CYP6P10v4 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948078
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 5
99% to CYP6P10v3
CYP6P10v5 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948079
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 6
99% to CYP6P10v4
CYP6P10v6 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427074.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 9
77% to CYP6P4, 1aa diff to CYP6P10v5
partial seq, 84 aa EXXR to heme
CYP6P10v7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427078.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 17
1aa diff to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v8 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427079.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 18
3aa diffs to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v9 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427080.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 19
3aa diffs to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v10 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427081.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 21
1aa diff to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P11 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427084.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 26
66% to CYP6P3, 63% to 6P6
partial seq, 84 aa EXXR to heme
CYP6P12v1 Aedes aegypti (yellow fever mosquito)
CYP6P12v2 Aedes aegypti (yellow fever mosquito)
CYP6P13 Anopheles funestus
No accession number
Tonderayi Matambo, Lizette Koekemoer
submitted to nomenclature committee 12/13/07
complete seq
93% to 6P9 full seq., 90% to 6P6
CYP6P14 Culex pipiens
CYP6Q1X Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene A
46% identical to CYP6A1 and 6E1 52% to 6N1
renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences
CYP6R1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene B
43% identical to CYP6Q1
CYP6R1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r3
CYP6S1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene C
45% identical to CYP6A1
CYP6S1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r2
CYP6S2 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 10/15/2001
clone name 24H06
72% identical to CYP6S1
CYP6S2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r1
CYP6S3 Aedes aegypti (yellow fever mosquito)
CYP6S4 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 27
77% to 6S3 Aedes, 66% to 6S1 Anopheles
CYP6S4 Culex pipiens
Cyp6t1 Drosophila melanogaster
GenEMBL AC012831 comp(42975-44564) no introns
Cyp6t1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6t2p Drosophila melanogaster
GenEMBL AC014742 1042-2504
Cyp6t3 Drosophila melanogaster
GenEMBL AC015208 comp(17123-18689)
Cyp6t3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6u1 Drosophila melanogaster
GenEMBL AC017706 15959-17471 also AC008288
Cyp6u1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6v1 Drosophila melanogaster
GenEMBL AC011761 comp(54926-57766) also AC015002
Cyp6v1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6w1 Drosophila melanogaster
GenEMBL AC014226 comp(15025-16689) also AC008257
Cyp6w1 Drosophila pseudoobscura