P450s that have appeared since the 1993 P450 nomenclature update.

      This is Part B of the P450 bibiographic files.  
      Sequences covered are CYP3 to CYP9.

      This list now includes all Drosophila P450s

      This includes references that were incomplete and duplications
      of sequences that were already in the update.  If a sequence 
      is assigned an accession number that was not in the old update
      it is included in this list.  
      Added 4A23-4A25, 6X1 9J1, 9J2, 
      4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
      Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
      Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2

      Added all human genes and pseudogenes
      Added CYP8B1 pig
      Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
      Added 25 Aedes and 104 Anopheles sequences
      Added CYP9G2
      This list was last revised on April 7, 2003. 
      Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
      July 2, 2003 added 4F42, 3A64, 4T6, 4T7
      Last revised Aug 19 2003, added 9A12
      Last revised Sept 26, 2003 added accessions for some old seqs.
      Last revised July 8, 2004 added Anopheles funestus CYP9s
      Last revised Jan. 31, 2005 added Anopheles funestus CYP6s and 4C25
      Last revised March 17, 2005 added Anopheles funestus CYP9L4 and 9K1
      Last revised June 24, 2005
      Last revised Jan. 4, 2006
      Last revised Dec. 31, 2007

3A Subfamily

4A Subfamily

4B Subfamily

4C Subfamily

4D Subfamily

4E Subfamily

4F Subfamily

4G Subfamily

4H Subfamily

4J Subfamily

4K Subfamily

4L Subfamily

4M Subfamily

4N Subfamily

4P Subfamily

4Q Subfamily

4R Subfamily

4S Subfamily

4T Subfamily

5A Subfamily

6A Subfamily

6B Subfamily

6C Subfamily

6D Subfamily

6E Subfamily

6F Subfamily

7A Subfamily

7B Subfamily

8A Subfamily

8B Subfamily

9A Subfamily

9B Subfamily

9C Subfamily


3A Subfamily

CYP3A1      rat
            GenEMBL D13912 (2023bp)
            Kirita,S. and Matsubara,T.
            cDNA cloning and characterization of a novel member of steroid-
            induced cytochrome P450 3A in rats
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: only 11 differences and two missing amino acids with 
            3A1.  All changes are limited to a 113 amino
            acid region, M10161 probably represents a hybrid seq. with Cyp3a2.
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            PIR S30378 (25 amino acids)
            Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
            M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
            Thomas, P.E.
            Regulation of two members of the steroid-inducible cytochrome
            P450 subfamily (3A) in rats.
            Arch. Biochem. Biophys. 301, 345-354 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL L24207 (2015bp)
            Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
            Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
            Unpublished (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
            Kirita,S. and Matsubara,T.
            cDNA cloning and characterization of a novel member of
            steroid-induced cytochrome P450 3A1 in rats.
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL M28452 (897bp)
            Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
            Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
            Demonstration in multiple species of inducible hepatic cytochromes
            P-450 and their mRNAs related to the glucocorticoid-inducible
            cytochrome P-450 of the rat
            Mol. Pharmacol. 28, 312-321 (1985)

            Komori,M. and Oda,Y.
            PIR JX0334 (502 amino acids)
            A major glucocorticoid-inducible P450 in rat liver is not 3A1.
            J. Biochem. 116, 114-120 (1994)
            Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
            Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.

CYP3A1      rat
            PIR S36137 (30 amino acids)
            Ribeiro, V. and Lechner, M.C.
            Cloning and characterization of a novel CYP3A1 allelic
            variant: Analysis of CYP3A1 and CYP3A2
            sex-hormone-dependent expression reveals that the CYP3A2
            gene is regulated by testosterone.
            Arch. Biochem. Biophys. 293, 147-152 (1992)
            This sequence agrees exactly with PIR JX0334, a 3A1 variant
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            PIR S27107 (24 amino acids)
            PIR S21697 (504 amino acids)
            Telhada,M.B., Pereira,T.M. and Lechner,M.C.
            Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
            Arch. Biochem. Biophys. 298, 715-725 (1992)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A2      rat
            GenEMBL M74443 (4230bp) U09725 to U09734 13 exons 
            Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
            A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
            Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
            U09725-U09734 report corrections to M74443

CYP3A2      rat
            Gen EMBL X79319 (8014bp)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of       
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
            unpublished (1994)

CYP3A2      rat
            GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
            unpublished (1994)

CYP3A2      rat
            GenEMBL U09742 (1936bp)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2: 
            Comparison of the cDNA with P450PCN2.
            unpublished (1994)

CYP3A2      rat
            Yamazoe,Y. et al. 
            Transcriptional elements directing a liver-specific expression of   
            P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
            Arch Biochem Biophys. 318, 71-79 (1995)

CYP3A2      rat
            PIR S30379 (25 amino acids)
            Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
            M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
            Thomas, P.E.
            Regulation of two members of the steroid-inducible cytochrome
            P450 subfamily (3A) in rats.
            Arch. Biochem. Biophys. 301, 345-354 (1993)

CYP3A2      rat
            GenEMBL S45634 (1572bp)
            PIR S27108 (36 amino acids)
            Telhada,M.B., Pereira,T.M. and Lechner,M.C.
            Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
            Arch. Biochem. Biophys. 298, 715-725 (1992)

CYP3A2      rat
            UCSC Browser chromosome 12
9570862 MDLLSALTLETWVLLAVILVL 9570800
9570429 LYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK 9570328
9566707 GLGRFDMECYKKYGKIWG 9566654
9564529 LFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR 9564431
9559660 DFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKE 9559547
9559467 MFPIIEQYGDILVKYLKQEAETGKPVTMKK 9559378
9559082 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSV 9558936
9556537 VLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHK 9556409
9555511 HRVDFLQLMLNAHNNSKDEVSHK 9555443
        ALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK in a seq gap
9551883 APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG 
        SVVTIPTYALHHDPQHWPKPEEFHPE 9551659
9550394 RFSKENKGSIHPYVYLPFGNGPRNCIDMRFALMNMKLALTKVLQNFSFQPCKETQ 9550230
9547469 IPLKLSRQAILEPEKPIVLKVLPRDAVINGA 9547377

CYP3A3X     human
            PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
            Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
            Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
            Complete cDNA sequence of a cytochrome P-450 inducible by
            glucocorticoids in human liver.
            Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
            This number is discontinued the seq = CYP3A4

CYP3A4      human
            GenEMBL D11131 (1345bp)
            Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
            Kamataki,T. and Itoh, S.
            Gene structure of CYP3A4 an adult-specific form of cytochrome
            P450 in human 
            livers and its transcriptional control.
            Eur. J. Biochem. 218, 585-595 (1993)

CYP3A4      human
            GenEMBL J04449 (2849bp)
            Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and 
            Guengerich,F.P.
            Characterization of mRNA species related to human liver cytochrome 
            P-450 nifedipine oxidase and the regulation of catalytic activity.
            J. Biol. Chem. 264, 910-919 (1989)
            nf-10 nifedipine oxidase (IIIA3)

CYP3A4      Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a4
            93% to 3A4 human

CYP3A4      Papio anubis (baboon)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            baboon3a4
            93% to 3A4 human

CYP3A4-ie1b human
            GenEMBL NT_007933.10|Hs7_8090
            alt exon 1 (partial)
            24614522   LIPNLAVETWLLL 24614484 

CYP3A4v1    Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            92% to human CYP3A4, 88% to human CYP3A7

CYP3A4v2    Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            92% to human CYP3A4, 88% to human CYP3A7
            1 aa diff to 3A4v1, 4 nuc. diffs

CYP3A5_v1   human
            PIR A60558 (29 amino acids)
            Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
            Identification of a polymorphically expressed member of the
            human cytochrome P-450III family.
            Mol. Pharmacol. 36, 97-105 (1989)

CYP3A5_v1   human
            GenEMBL S74699 (1526bp) S74700 (1667bp)
            Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
            Sequence of the 5'-flanking region of CYP3A5: comparative analysis
            with CYP3A4 and CYP3A7.
            Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)

CYP3A5_v1   human
            GenEMBL AC005020 genomic sequence 13 exons
            Same intron exon structure as CYP3A43 from human

CYP3A5-de1b2b human
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 
            alt exon 1 and 2 upstream of 3A5
            239409 MDLIPNLAVETWLLLAVSLVLLYL
            243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697

CYP3A5-de13c human
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 detritus exon 13 upstream of 3A5
            old name = 3A51P
            254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13

CYP3A5_v2   human
            GenEMBL L26985 (1599bp)
            Schuetz,J.D.
            unpublished (1994)
            formerly CYP3A5P1, new name = CYP3A5_v2 short for: 
            CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
            14n, 15n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5_v3   human
            GenEMBL X90579 (?bp)
            Maurel,P. and Jounaidi,Y.
            unpublished (1995)
            note: a second pseudogene similar to CYP3A5P1
            formerly CYP3A5P2, new name = CYP3A5_v3 short for: 
            CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
            14n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5P1X   human
            GenEMBL L26985 (1599bp)
            Schuetz,J.D.
            unpublished (1994)
            new name = CYP3A5_v2 short for: 
            CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
            14n, 15n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5P2X   human
            GenEMBL X90579 (?bp)
            Maurel,P. and Jounaidi,Y.
            unpublished (1995)
            note: a second pseudogene similar to CYP3A5P1
            new name = CYP3A5_v3 short for: 
            CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
            14n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5      Macaca mulatta (rhesus monkey)
            No accession number
            Brian A. Carr, Merck & Co. Inc.
            Submitted to nomenclature committee 4/22/2004
            91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
            name has been changed to indicate orthology formerly CYP3A66

CYP3A5      Macaca fasicularis (cynomolgus monkey)
            No accession number
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP3A5_2-F5
            3 aa diffs to 3A5 Macaca mulatta 

CYP3A5      Macaca fasicularis (cynomolgus monkey)
            No accession number
            Wu Zhicong
            Submitted to nomenclature committee 10/30/2006
            91% to 3A5 human, 84% to 3A4, 80% to 3A7, 75% to 3A43
            100% identical to Unos seq.

CYP3A5      Callithrix jacchus (marmoset)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Cja3a5b
            89% to 3A5 human, probable ortholog of CYP3A5
            note: there is a second gene CYP3A90 that is 95% identical to this
            it is a paralog of the CYP3A5 gene

CYP3A5      Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a5
            98% to 3A5 human

CYP3A6      rabbit 
            GenEMBL J05034, M19139

CYP3A7      human
            NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

CYP3A7-de1b2b human
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 alt exon 1 and 2 upstream of 3A7
            186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
            191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2

CYP3A7      Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            89% to human CYP3A7, 89% to human CYP3A4
            82% to human 3A5 and 73% to 3A43
            note: this seq is equally similar to 3A7 and 3A4
            but there is another seq with a better match to 
            3A4 in African green monkey, so this must be
            the 3A7 ortholog

CYP3A7      Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a7
            96% to 3A7 human

CYP3A7      Papio anubis (baboon)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            baboon3a7-like
            92% to 3A7 human

CYP3A7      Macaca mulatta (rhesus monkey)
            AANU01101873.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mmul3a7-like
            91% to 3A7 human
24981 MDLIPDLAVETWLPLAVSLILLYL
      YGTHSHGLFKKLGIPGPTPLPFFGNVLSFRK  29288
34310 GFWTFDMECYKKYRKVWG  34363
35908 FYDCRQPVLAITDPNMIKTVLVKECYSVFTNRR  36006
38516 PLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKE  38629
38894 MVPIIAQYGDVLVRNLRREAETGKPVTLKD  38983
40270 VFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDPFFLSIK 40416
41507 IFPFLTPIFEALNITVFPRKVTRFLRKSVKRMKEGRLKETQK  41632
42652 RRVDFLQLMIDSQNSKDTESHK  42717
45311 VLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDTVLPNK 45472
46900 APPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGVVVMIP 
47094
47095 SYVLHHDPKYWTEPEKFLPER
48220 RFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ  48384
51270 IPLKLSFGGLLKTEKPIVLTAESRDGTVSGA*  51371

CYP3A8      Macaca fasicularis (monkey)
            GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
            PIR S28168 (503 amino acids)
            Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
            and Kamataki,T.
            Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450.
            Biochim. Biophys. Acta 1171, 141-146 (1992)

CYP3A8      Macaca fasicularis (monkey)
            Swiss P25231 (22 amino acids)
            Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and   
            Kamataki,T.
            Biochim. Biophys. Acta 996, 142-145 (1989)

CYP3A8      Macaca fasicularis (monkey)
            PIR S36875 (13 amino acids)
            Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
            Purification and characterization of two forms of hepatic microsomal
            cytochrome P450 from untreated cynomolgus monkeys.
            Arch. Biochem. Biophys. 305, 405-413 (1993)

CYP3A9      rat
            GenEMBL U46118(2101bp)
            Wang,H., Kawashima,H. and Strobel,H.W.
            cDNA cloning of a novel CYP3A from rat brain
            Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)

CYP3A9      rat
            GenEMBL U60085(1882bp)
            Nef,P.
            Hepatic expression and inducibilty of CYP3A9 and other members of
            the rat CYP3A subfamily.
            unpublished (1996)

CYP3A9      rat
            UCSC Browser chromosome 12
some frameshifts in genome seq of exon 8
17153442 MDLIPNFSMETWLLLVISLVLLYL 17153513
17155488 YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK 17155580
17156990 GFWEFDKYCHKKYGKLWG 17157043
17159222 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17159320
17163193 NFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKE 17163306
17163523 MFPIINQYTDMLVRNMRQGSEEGKPTSMKD 17163606
17165013 IFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSV 17165159
17168128 TLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKE 17168226 NRMKEKEK
17170690 QRMDFLQLMINSQNSKVKDSHK 17170755
17177660 ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK 17177821
17179040 AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
         VVMIPTFALHKDPHYWPEPEEFRPE 17179264
17191573 RFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKET 17191734
17192800 QIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA 17192895

CYP3A9-se1[4]X rat
              UCSC Browser chromosome 12
              Note: the revised genome probably has this as part of Cyp3a62
              Discontinued name
17387311 LYEGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17387213 exon 4 

CYP3A9-se1[1:2:4] rat
          193 kb downstream of Cyp3a9 on opposite strand
          100% match to Cyp3a9
MDLIPNFSMETWLLLVISLVLLYL
YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK
LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR

CYP3A10     hamster
            GenEMBL M73992 (2015bp)
            Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
            Nucleotide and deduced amino acid sequence of a new rat CYP3A form
            unpublished (1993)

Cyp3a11     mouse
            PIR A60564 (24 amino acids)
            Bornheim, L.M. and Correia, M.A.
            Purification and characterization of a mouse liver cytochrome
            P-450 induced by cannabidiol.
            Mol. Pharmacol. 36, 377-383 (1989)

Cyp3a11     mouse
            GenEMBL X60452, AC111090.20 genomic clone (seq shown)
104114 MDLVSALSLETWVLLAISLVLLYR 104185
106160 YGTRKHELFKKQGIPGPKPLPFLGTVLNYYK 106252
108416 GLWKFDMECYKKYGKTWG 108469
110360 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR 110458
114653 DFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKE 114766
114846 MFPVIEQYGDILVKYLRQKAKKGKPVTMKD 114935
115207 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSV 115353
117878 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQK 118006
118896 HRVDFLQLMMNSHNNSKDKVSHK 118964
121382 ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK 121543
123352 APPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALH
       HDPQHWSEPEEFQPER 123579
125008 FSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 125169
128728 IPLKLSRQGLLQPEKPIVLKVVPRDAVITGA 128820

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a11-de12bX mouse
           old name Cyp3a-se11[12] also = Cyp3a-se6[12]
           this fragment has joined with Cyp3a44-de9b10b11b
           to make Cyp3a44-de9b10b11b12b (see below)
137165 RFSMENKGSIDPY 137127
137122 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 136997

CYP3A12     dog
            PIR S04341 (28 amino acids)
            Ciaccio, P.J. and Halpert, J.R.
            Characterization of a phenobarbital-inducible dog liver
            cytochrome P450 structurally related to rat and human
            enzymes of the P450IIIA (steroid-inducible) gene subfamily.
            Arch. Biochem. Biophys. 271, 284-299 (1989)

Cyp3a13     mouse
            GenEMBL X63023(1881bp) also NT_039315.1
            Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
            Molecular cloning and functional expression of a mouse cytochrome
            P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
            aflatoxin B1 (AFB1).
            Biochim. Biophys. Acta 1201 (3), 405-410 (1994)

CYP3A14     Cavia cobaya (guinea pig)
            GenEMBL D16363 (1827bp)
            Mori,T., Itoh,S. and Kamataki,T.
            cDNA and deduced amino acid sequence of a novel cytochrome
            P450 from male guinea pig liver mRNA with high homology to 
            CYP3a family
            unpublished (1993)

CYP3A14     Cavia porcellus (guinea pig)
            GenEMBL D49731 (2321bp)
            Mori,T., Itoh,S. and Kamataki,T.
            Differential effects of ascorbic acid deficiency on the expression
            of the forms of cytochrome P450.
            Unpublished (1995)

CYP3A15     Cavia cobaya (guinea pig)
            GenEMBL D26487 (2163bp)
            Mori,T., Itoh,S. and Kamataki,T.
            Differential effects of ascorbic acid deficiency on the expression
            of the forms of cytochrome P450.
            Unpublished (1995)

Cyp3a16     mouse
            GenEMBL D26137 (1701bp) also NT_039318 
            Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
            A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning 
            and expression in fetal liver.
            Eur. J. Biochem. 226, 877-882 (1994)

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a16-de12b mouse 
           GenEMBL NT_039318 - strand 
           detritus exon 12
           z in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1616751 GPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1616647

CYP3A17     guinea pig 
            GenEMBL D28515 
            Mori,T.
            submitted to Nomenclature Committee 
            Not in Genbank as of 6/26/95

CYP3A18     rat
            no accession number
            Kiyoshi Nagata
            6-beta-C
            submitted to Nomenclature Committee 

CYP3A18     rat
            GenEMBL X79991 (2005bp)
            Strotkamp,D., Roos,P.H. and Hanstein,W.G.
            A novel CYP3 from female rats.
            Biochim. Biophys. Acta 1260, 341-344 (1994)

CYP3A18     rat
            GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
            Yamazoe,Y. et al. 
            Isolation and characterization of of a new rat P450 (CYP3A18) cDNA 
            encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
            Pharmacogenetics in press (1995)

CYP3A18     rat
            UCSC Browser chromosome 12
9166475 MEIIPNLSIETWVLLATSLMLFYI 9166404
9156355 YGTYSHGLFKKLGIPGPKPVPLFGTIFNYGD 9156263
9143764 GMWKFDDDCYKKYGKIWG 9143711
9141173 FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR 9141075
9137566 CFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKE 9137453
9136038 MFPLMRQYGDTLLKNLRREEAKGEPINMKD 9135949
9135719 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSV 9135573
9133657 VLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQK 9133529
9132027 NRVDFLQLMMNTQNSKGQESQK 9131965
9129047 ALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK 9128886
9126077 APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
        VVTIPIYPLHRNPEYWLEPEEFNPE 9125853
9120566 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 9120405
9117192 QIPLKISRQPIFQPEGPIILKLVSRD 9117115

CYP3A18-se1[5:6:7:8]   rat
            UCSC Browser chromosome 12
64% to 3A18
9216052 FGPVGFMKKAVTISEDDEGKRLRPLLSPVFTSGK 9216153
9216386 LWLLHFGLMCSPSSGSVMSVKHLRQEEKGEPIHMKE 9216493
9216722 FSGAYSMNGIAGASFGVNVDSLNN 9216781
XXXXXXXXXXXXXXXXXXXXXXXX
VVLFPFLTQI

CYP3A19     Capra hircus (goat)
            GenEMBL X76503 (1084bp)
            Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
            Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
            cDNA and deduced amino acid sequence of a dwarf goat liver
            cytochrome P450-fragment belonging to the CYP2C gene subfamily
            Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
            C-terminal fragment from I-helix to end

CYP3A20     Guinea pig 
            GenEMBL 
            T. Mori
            unpublished

CYP3A21     Marmoset
            GenEMBL 
            Igarishi, T. 
            unpublished

CYP3A22     Miniature pig
            GenEMBL AB006010
            Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
            Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
            Drug Metab. Disp. 32, 376-378 (2004)

CYP3A23     rat 
            GenEMBL D13912
            Kirita,S. and Matsubara,T.
            Cloning and characterization of a novel member of steroid induced 
            cytochrome P450 3A in rats.
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A23     rat 
            GenEMBL D29967
            Komori,M. and Oda,Y.
            A major glucocorticoid inducible P450 in rat liver is not P4503A1
            J. Biochem. 116, 114-120 (1994)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A23     rat 
            UCSC Browser chromosome 12
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.
9625823 MDLLSALTLETWVLLAVVLVLLY 9625755
9623782 GFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM 9623687
9621110 GLWKFDVECHKKYGKIWG 9621057
9617991 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR 9617893
9616272 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKE 9616159
9616079 MFPVIEQYGDILVKYLRQEKGKPVPVKE 9615996
9615715 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV 9615569
9614012 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDS 9613893
9613004 VQKHRVDFLQLMMNAHNDSKDKESHT 9612936
9607896 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNK 9607735
9605981 APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKG
        SVVMIPSYALHRDPQHWPEPEEFRPE 9605757
9604349 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 9604188
9597247 QIPLKLSRQGLLQPTKPIILKVVPRDEIITGS 9597152

CYP3A24     sheep
            GenEMBL U59378(1653bp)
            Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
            and Morgan,D.J.
            Ovine foetal liver CYP3A24
            unpublished (1996)

Cyp3a25     mouse
            GenEMBL AF204959
            Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
            submitted to Nomenclature Committee 10/18/96
            Cloning, sequencing, heterologous expression and characterization
            of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
            Unpublished
MELIPNLSIETWVLLVTSLVLFYI
YGTYSHGLFKKLGIPGPKPLPLLGTIFNYYD
GMWKFDEDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
FFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPISMKD
IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKVFDPFLLS
IILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQK 
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ
IPLKISREPIFQPEKPIILKVVSRDKPRTGS

Cyp3a25     mouse
            GenEMBL Y11995
            Mahnke,A., Roos,P. and Hanstein,W.G.
            one amino acid difference with Roses sequence at amino acid 215
            unpublished

Cyp3a25     mouse
            GenEMBL AC111090.20 genomic clone
            Last two exons.  This clone also contains CYP3a11, Cyp3a44 and the 
            region between them.  This helps to close the gap in the 3a cluster
            shown in Fig 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
2345 FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 2506
6188 IPLKISREPIFQPEKPIILKVVSRDKPRTGS 6280

Cyp3a25-de8b9b12b mouse
            GenEMBL AC111090.20 genomic clone
            r in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
27841 PVFFSFLIPI*EMLNISVFQKGSIAFFKKFVDRMNESRPDSKQK 27710
18903 DLVGFLQPMINAHNNPKDKESHNG 18832
15460 XXXXXXGSID-YVYLSFGNGPRIYIGVRFTLMNMKVLTLTKVLHNFSFHPCKET* 15317

Cyp3a25-de11c mouse
           GenEMBL NT_039324.1 - strand 
           detritus exon 11
           q in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
168333 XPVTLGTLVEIEYPDMVVT*ILILYPIGNRPESVCKEGFEVFIPKGTRVTVPTFALH*DPQYWPELEKXXXXX 168133

CYP3A26     dog
            no accession number
            David Fraser
            submitted to Nomenclature Committee 
            95.6% identical to 3A12 from dog

CYP3A27     Oncorhynchus mykiss (rainbow trout)
            GenEMBL U96077
            Don R. Buhler
            Arch. Biochem. Biophys. 360, 000-000 (1998) in press
            56% identical to 3A12

CYP3A28     Bos taurus (cow)
            GenEMBL Y10214(1870bp)
            Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
            Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
            Witkamp,R.F. and Horbach,G.J.
            Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
            and its functional expression in V79 cells.
            unpublished (1997)

CYP3A28     Bos taurus (cow)
            See cattle page for details
MELIPSFSMETWVLLATSLVLLYI (2)
YGTYSYGLFKKLGIPGPRPVPYFGSTMAYHK (0)
GIPEFDNQCFKKYGKMWG (2)
FYEGRQPMLAITDPDIIKTVLVKECYSVFTNRR (0)
IFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKE (0)
MFPIIGQYGDMLVRNLRKEAEKGNPVNMKD (2)
MFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSI (1)
ILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQM (0)
NRVDLLQLMINSQNSKEIDNHK (1)
ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNK (0)
APPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPER (2)
FSKNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQ (0)
IPLKLYTQGLTQPEQPVILKVVPRGLGPQVEPDFL*

CYP3A29v1   pig
            GenEMBL Z93099 (2015bp)
            Nissen,P.H., Winteroe,A.K. and Fredholm,M.
            Characterization and mapping of three porcine genes belonging to
            the cytochrome P450 superfamily
            Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA

CYP3A29v2   Sus scrofa (pig)
            GenEMBL AB052260 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            2 amino acid diffs with 3A29v1
              clone name 3Ac9

CYP3A29v3   Sus scrofa (pig)
            GenEMBL AB052261
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A29v1
              clone name 3Ac16

CYP3A29v4   Sus scrofa (pig)
            GenEMBL AB052262
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
              clone name 3Ac25

CYP3A29v5  Sus scrofa (mini pig)
     GenEMBL AF424780
     Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
     cDNA of minipig cytochrome P450 3A
     Unpublished
     75% to 3A4 human 98% to 3A29v1 8 diffs.  
     3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
     4 diffs with 329v2 (Partial seq from 99-328)
     
CYP3A30     Fundulus heteroclitus
            Genbank AF105068
            Malin Celander and John J. Stegeman
            Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the 
            marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A 
            genes. 
            Biochem. Biophys. Res. Commun. 236, 306-312 (1997)

CYP3A31     Syrian hamster
            GenEMBL D86951
            Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
            Nagata,K. and Yamazoe,Y.
            cDNA cloning and expression of a novel CYP3A from the Syrian
            hamster, CYP3A31
            Biochim. Biophys. Acta 1397, 9-13 (1998)
            clone name P450SH3A-1

CYP3A32     Balaenoptera acutorostrata  (Minke whale)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A33     Phocoenoides dalli (Dall's porpoise)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A34     Eumetopias jubatus (Steller sea lion)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A35     Phoca largha (Spotted seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A36     Phoca fasciata (Ribbon seal)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A37     Gallus gallus (chicken)
            no accession number
            Manuel Baader and Urs Meyer
            submitted to nomencalture committee
            60% identical to mammalian CYP3A sequences

CYP3A37     Gallus gallus (chicken)
            GenEMBL NM_001001751.1
            Note: chicken has two CYP3As about 25kb apart on chr 14
            See CYP3A80
MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI
QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI
ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ
QKVVNEIDTILPNKAPLTYEAIMQLEYLDMAVNETLRLYPLGGRLERTCKRDVEINGV
TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG
MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPRTNTAKA

CYP3A37     Meleagris gallopavo (turkey) 
            No accession number
            Shirley Yip, Roger Coulombe, Jr.
            Submitted to nomenclature committee Jan. 20, 2006
            Clone name CYP3A-F4
            92% to chicken 3A37 probable ortholog

CYP3A37     Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_1137:6582-24650, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca4.
            69% to CYP3A37 chick (ortholog), 64% to CYP3A113, 
            63% to CYP3A98 dog, 63% to 3A80 chicken
MELLPSFSIETWSFLVVLLGLLLLYGIWPFGVFGKLGIPGPRPWPFLGTLLQYRKGFVKFDSWCFQKYGRIWGIYDGRQPVM
AILDPAIIKTVLVKECYTTFTNRRNFGATGVLKSAISLAEDEHWKRVRTVLSPTFTSGKLKEMFPIIKHYGEALMRNVQKKV
DMDEPLVVKDVFGAYAMDVVTSTSFGVNIDSMNNPKDPFVKEIQKLTKFRSFDPRIILLFTFPILRTVFEALNIQIFSAEAV
DFFTRSFAKMKAGRAGETKEGRVDFLQLMIDSQTSNGHHQSNGIDHTYKGLTDDEILAQAFIFVFAGYEPTSNSLGYMAYML
ATHPDVQQKLQDEIDSVLPNKAPLTYDAIMQLEYLDMVLNETQRLYPLGGRIERVCKKDVEINGVTIPKGVVVMIPPYNLHR
DQEYWPEPEEFRPERFSKENKESVDPYTYLPFGAGPRNCIGMRFALVTMKVAITILLQHFSFRVCKETPIPLELSSQAFLVP
EKPIVLKLVRRNNLQ

CYP3A38     Medaka (fish)
            no accession number
            Seth Kullman
            submitted to nomenclature committee 11/6/98
            72% identical to CYP3A27 trout

CYP3A39v1   Sus scrofa (pig)
            GenEMBL AF109068, NM_214422
            Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
            Porcine Cytochrome-P450 with high protein homology to human CYP3A4
            (Nifedipine oxidase J04449)
            Unpublished
            88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA

CYP3A39v2   Sus scrofa (pig)
            GenEMBL AB052263 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
            clone name 3Ac13

CYP3A39v3   Sus scrofa (pig)
            GenEMBL AB052264 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
            clone name 3Ac19

CYP3A39v4   Sus scrofa (pig)
            GenEMBL AB052265 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
            clone name 3Ac32

CYP3A39v5  Sus scrofa (miniature pig) 
           no accession number
           Haitao Shang
           Submitted to nomenclature committee May 23, 2007
           partial sequence with frameshifts before I-helix
           95% to CYP39A1v1 NM_214422 
           only 2 aa diffs in first 193 aa

CYP3A40     medaka
            no accession number
            Seth Kullman
            submitted to nomenclature committee 1/12/99
            90% identical to CYP3A38 trout

Cyp3a41     mouse 
            GenEMBL NM_017396 AB033414
            Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
            Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene 
            subfamily in the mouse liver
            Arch. Biochem. Biophys. 377 (1), 153-162 (2000)            
            91% identical to 3a11 87% identical to 3a16 69% to 3a25 and 
            68% to 3a13 90% to 3a44
            submitted to nomenclature committee 6/1/99
MNLFSALSLDTWVLLAIILVLLYR
YGTRTHGLFKKQGIPGPTPLPFLGTVLNYYK
GLWKFDMECYEKYGKTWG
LFDGQMPLFVITDPEMIKNVLVKECFSVFTNRR
EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKE
MFPVIEQYGDILVKYLMQEAEKGKPVTMKD
VLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFS
VVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQK
HRVDFLQLMMNAHNNSKDKDSHK
ALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK
APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPER
FSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ
IPLKLSRQGLLQPEKPIVLKVVPRDVVITGA

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a41-de1b2b mouse
           GenEMBL NT_039318 
           exon 1,2 - strand 
           y in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
           possible alternative exons for 3a41
1729618 MNLFSALSLDTLVLLAIILVLLYR 1729547
1727537 YGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK 1727445

Note: These two exons are identical to 3A16 exons 1 and 2
This sequence is at the edge of the genome sequence gap between 3a41 and 3a44
The NT_039318 sequence has been removed in the new mouse genome assembly,
So these sequences could be due to errors in assembly.

Cyp3a41-de12c mouse
           GenEMBL NT_039318 - strand
           detritus exon 12 
           x in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1739825 SNGPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1739715

note this seq is nearly identical to Cyp3a16-de12b
it is in a region of some uncertainty, and may be due to errors in assembly.

CYP3A42     Python regius (ball python or royal python, African snake) 
            GenEMBL AF319041
            Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
            Submitted to nomenclature committee Oct 22, 1999
            59% to mouse 3a

CYP3A43     human
            GenEMBL AC011904 8902-46787 13 exons
            Gene assembled from genomic sequence by Henry Strobel 
            and David Nelson on Dec 11, 1999
            intron exon boundaries defined by comparison to rat 3A9
            and human 3A sequences.  GT AG pairs found for all introns
            ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
            Opposite ends of same clone
            67% identical to rat 3A9

Assembled gene * = intron exon boundary ** = EST support for this boundary

MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI* 
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*

coding region 504 amino acids

exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787

CYP3A43-de1b human
            GenEMBL NT_007933.10|Hs7_8090  + strand alternate exon 1
            24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214

CYP3A43-de4c6c 
            GenEMBL NT_007933.12|Hs7_8090 
            chromosome 7 genomic contig
            Length = 64383103
            Last exon of 3A43 in build 33 of human genome
            24697113 IPLKLDNLPILQPEKPIVLKVHLRDGITSGP* 24697208
            CYP3A43-de4c6c = s in Fig. 3A, 
            old names = 3A52P, 3A53P 
            Exon 4 pseudogene fragment
            24701048 MIKTVLVKECYSVFPNWR 24701101
            exon 6 pseudogene fragment
            24703375 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 24703464

CYP3A43     Macaca fasicularis (cynomolgus monkey)
            No accession number
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP3A43
            96% to human CYP3A43 only 75% to 3A4, 3A5

CYP3A43     Macaca mulatta (rhesus monkey)
            XM_001098213.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mmul3a43
            96% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETSLHHSLSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQLPLKLNNLPILQPENPIVLKVHLRDGITSGP

CYP3A43     Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a43
            98% to 3A43 human

Cyp3a44     mouse
            GenEMBL AB039380
            Tsutomu Sakuma
            Submitted to nomenclature committee 2/29/2000
            This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)

Cyp3a44     mouse
            GenEMBL AC111090.20 genomic clone
            This clone contains part of 3a25, Cyp3a25-de8b9b12b, 3a11, 
            A pseudogene between 3a11 and 3a44, and most of 3a44
178101 MNLFSALSLDTLVLLAIILVLLYR 178172
180134 YGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT 180226
182562 GIWKFDMECYEKYGKTWG 182615
184471 LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRR 184569
188874 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 188987
189067 MFPVIEQYGDILVKYLRQEAEKGMPVAMKD 189156
189424 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSV 189570
192147 VLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQK 192275
193171 HRVDFLQLMMNSHNNSKDKDSHK 193239
195368 AFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNK 195529
204141 ATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPS 204308
204309 YALHHDPQHWPDPEEF 204356 (runs off end, last section from AB039380)
       QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLA
       VTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA

Cyp3a44-de9b10b11b12b     mouse
           GenEMBL AC111090.20 genomic clone
           This seq is between 3a11 and 3a44. It is 13kb from 3a44, 20kb from 3a11
           The exon 12 part used to be called Cyp3a11-de12b
           The exon 9 part is identical to w in Figure 3B Nelson et al.     
           Pharmacogenetics 14, 1-18 2004.
165130 HQVDFLHLMINAHDKTKDKETHK 165062
160280 ALSNMEITTQSIMFIFASYKPTSSTLSFALCSLVTHHAS*KKLQENDKTLTNK 160122
156349 VELESLDMVLNETLRLYPTADRLVKVYKKDVELNDAFILKWSLEIVSCYSLCHDPQNWPEHKEFCPE 156149
148858 RFSMENKGSIDPYG 148817
148815 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 148690

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Note: the following sequences (4 exons) lie between 3a41b and 3a44
Cyp3a41b-de12b
(-)15459 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQ 15298
3 aa diffs to Cyp3a-se5[12]

Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]

CYP3A45     Oncorhynchus mykiss (rainbow trout)
            No accession number
            Su-Jun Lee, Don R. Buhler 
            96% to 3A27 but different 3 prime and 5 prime ends

CYP3A46v1   Sus scrofa (pig)
            GenEMBL AB052266 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
            clone name 3Ac4

CYP3A46v2   Sus scrofa (pig)
            GenEMBL AB052267 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
            clone name 3Ac28

CYP3A47X    Fugu rubripes (pufferfish)
            No accession number
            Scaffold 600
            Renamed CYP3D1
      MNYLPLFALETWILLITFTCLFVM (2)
      YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
      NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
      IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
      FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPPLHDPSTSP (1)
      Cannot identify exon 8 in this region
  (0) EFDFLQHMISTQKNDGIYAVTS
  (1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
      LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
      FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
      IPFKMDPNTFVGPINPIKLRVVRR*

CYP3A48     Fugu rubripes (pufferfish)
            No accession number
            Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803

CYP3A48     Tetraodon nigroviridis (freshwater puffer)
            CAF91666 GenPept
            85% to 3A48 full (probable ortholog), 87% to 3A49 C-term fragment,
MDLLPDFSIETWTLIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGVHHFDQECYKKYGKVWSLFDGRQPLM
CIMDTLMIKTILIKECYSNFTNRRDLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKV
KADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILVVLFPFTQTIFDKMDVSLFPGHVL
DFFYNFLRQIKSDRSKEKKKSRVDFMQLMVNAHMTEDNEKDSSLKGLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNP
DIQKKLQEEIDKTFPGKVRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPAL
WPEPEAFKPERFSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPI
KLKLKPRTSS

CYP3A48     Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrXII:12771920-12775348, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            gac2628
            70% to 3A48 Fugu, 72% to tetraodon 3A48,
MGFLPELSIQTWTLIVFLVTLITVYGYAPYGFFKKLGIPGPRPLPFIGTFLEYRKGIHNFDTECYEKYGKVWGIYDGRVPIL
VTMDTAMIKSILVKECYSNFTNRRDFGLNGALRDAITVVEDEEWKRIRSILSPSFTSGRLKEMYSIMLQHSGNLIKSLHKKA
EAGEVVDVKDIFGPYSMDVVASTAFSVDIDSINNPSDPFVANIRKLVKFTFLTPLFLLLVLFPFLEPMLDKMNVTLFPAELL
DFFYSFLKTIKSDRSKNEHKNRVDIMQLMVDSQMSETTKEDPSAHKGLSDSEILSQAMIFIFAGYETSSGTLGFLAYNLATN
PDIQKTLQEEIDETFPNKARPTYDALMQMEYLDMVLNESMRLYPSGNRLDRVSKSSVEIEGVTIPKGTVVMIPVYTLHREPT
LWPEPDDFKPERFSKENKDSIDPYSYLPFGAGPRNCIGMRFALLMMKLSVVEILQNFSFVTCKETQIPLELSTDGFTTPKDS
INLKLEPRGAHC

CYP3A49     Fugu rubripes (pufferfish)
            No accession number
            Scaffold 1124b length 48103 gene runs off end of scaffold
48101 XXXXYEILAQ 48804 frameshift
48084 AIFFIFAGYELPAALLDFANNLATNPKIQKKLQEEIDKTFPGK 47956 (0)
47876 VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQ 47697
47696 RDPVLWPEPEAFKPER 47648 (2)
47492 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCQETD (0) 47331
47246 IPMVLGNEGFVTPKNPIKLKLKLRDVFN* 47160

CYP3A50P    Fugu rubripes (pufferfish)
            No accession number
            Scaffold 10760 probable pseudogene
1847 MNFLPDFFLNTWTFLILVIVLSTT 1918 (2) exon 1
2258 bad boundary MDVLHMSSIKRVGIRRPKTWPIIGTYNRTDG 2350 bad boundary exon 2
     cannot identify exons 3-6
3091 XXXXXXXXXXXXXXFSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG 3195 (1) part of exon 7
3268 AIFPFLTPLMD 3300 start of exon 8 
     Seq gap in scaffold
3919 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYNLAVHPQTQTRLQAEIDRTFPGK 3990 exon 10
4078 CLITYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSGVIIPEGVAVAVPIYTLH 4257
4258 RDPTVWPDPDSFKPERFSKDNRDNIDPYGLLTR 4424 frameshift and 7 nuc. deletion 
4423 GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM 4527
     IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN* 4787

CYP3A51PX  human
           NT_033964.1|Hs7_34119 chromosome 7 
           detritus exon 13 upstream of 3A5
           new name = CYP3A5-de13b
           254205 QIPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13 

CYP3A52PX  human
           AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4 
           New name = CYP3A43-de4c6c
           MIKTVLVKECYSVFPNWR

CYP3A53PX  human
           NT_033964.1|Hs7_34119 Homo sapiens chromosome 7 
           detritus exon 6 downstream of 3A43
           new name = CYP3A43-de4c6c
           67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6

CYP3A54PX  human
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 2
           new name = 3A-se1[2]
           2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548

CYP3A55PX  human
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 5
           new name = 3A-se2[5]
           2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579

CYP3A56    Fundulus heteroclitus (killifish)
           No accession number
           Tove Hegelund and Malin Celander
           64% to 3A48 Fugu 99% to 3A30
           submitted to nomenclature committee 6/20/02

Cyp3a57    mouse 
           GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
           AC115895.4 13 exons, exon 9 is backwards
           NT_039318
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS 
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP

Cyp3a58-ps mouse
           GenEMBL NT_039318 + strand 
           Between 3a16 and 3a41
           Note this seq is 86% identical to Cyp3a44-de9b10b11b12b
           [3a16, 3a58-ps, 3a41] is probably a tandem duplication of 
           [3a44, 3a44-de9b10b11b12b, 3a11]
           exon 8
1629527 PVFFSFLNPI*EMLKISVFPKDSIAFFKKKLWTEQRKTSWILSKR 1629661
exon 9 new fron UCSC Browser
26701 HQVDFLHLMINAHDNTKDNESHK 26769
           exon 10
1651425 ALSNIEITTQSIMFIFASYEPTSSTLSFVLYLLVTHHDIWKKLQENDRALPNK 1651583
           exon 11
1660734 VEMEYLDMVLNETLRLYPTADRFVKVYKKDVELNDAFILKWS 1660859
           exon 12
1669382 FSMENKGSIDPYX 1669417
1669422 YMPFGNGPRNCISMRFAVMSMKFALTKVLQNCYLHPCKETQ 1669544


Cyp3a59    mouse
           GenEMBL NW_000248.1|Mm5_WIFeb01_96 gene interrupted by gaps 
           AC113316.2
           old temp name = cyp3agg 
           93% to Cyp3a25
LLLYRYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFD
GMWKFDEDCYKKYGKIWG 
FYVGPKPILAIMDPEIIKIVLVKECYSVFTNR 
RLLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPINMKE
IFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLS
VVLFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLH
RNPEYWPEPQEFCPG
RFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQ
IPLKISREPVFQPEKPIILKVVSRDKPRT

Cyp3a59-de11b mouse
           GenEMBL NT_039324.1 - strand 
           detritus exon 11
           p in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
191646 VSFLLVTLVEIEYLDILVT*ILRLNPIGNRLESVSKK 191536
191539 EMFEVFIPKGTRVTVLTFALH*DEQYWPEXXXXXXXX 191453

Cyp3a60-ps  mouse
           GenEMBL NT_039324.1 + strand 
           Cyp3a ps about 60% to 3A25
exon 2
331420 PVRLPVIGLLLSLYN 331464
exon 5
338061 KKVITISEEDERKRL*TLLSPTFIS 338135
exon 6
338410 MFPIIGQYGETLVK  338451
338451 KKRKGEPINMKE 338486
exon 7
338734 SMDVVTGTLFGVNVDSLTNSSDPCAESQGDLNKFEFS*PTSLG 338862
exon 8
341951 VAMLPFLTTIYKILSISIFP 342010
342409 KYMKQSRLDTNQK 342447

Cyp3a61-ps  mouse
           GenEMBL NT_039315.1, also on NW_000239.1
           Old temp name = Cyp3ayyp 
           Exons 10,11,12,13 
1115767 ALSDLEIVAQSISFIFAGYETTSNTLSYIMYTLATHPDVQKKLQQEIDAILPNK 1115606
1113252 APATYNDLEKIEYLDMVINETLRLYPIGARISRLSKKDAEINGVFIPQNTEVAVPVF 1113082
1109396 FSQENKDRINPYVYMPFGNGPRNCLGMRFALINMKLAVVKILQNFSVQPCEDTE (0) 1109235
1108058 IPLKLSKKLILSPEKPIVLKVTARDGAINEG* 7963

Cyp3a61-de11b mouse
           GenEMBL NT_039315.1, also on NW_000239.1
           Old temp name = Cyp3azzp 
           detritus exon 11 next to Cyp3a61-ps
           n in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1136553 APATYNGLVKIRYLDMVINETLRLYPVGVRISRLSKKDAEINGVLTPQNTK
        VDVALFVLH*DPEYWPXXXXXXXXX 1136353

CYP3A62     rat
            GenEMBL AB084894 
            Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
            Isolation and characterization of a novel rat CYP3A, CYP3AL1, 
            predominantly expressed in intestinal tract  Unpublished 2003
            80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD

Cyp3a62-de11b     rat
        GenEMBL NW_001084671.1 11932479-11932637
11932637  KKNQDSISPYVYLPFGFRPRNCIGMRFALMNMKVALVRVLQNFSFQPCKEIQL  11932479

Cyp3a63-ps  mouse
The following seqs are part of one pseudogene 3a63-ps
           GenEMBL NT_045749.1|MmUn_45789_30 
           3a exon 2 same as 3a63-ps
396 YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK 304
           NT_071156.1|MmUn_71196_30 
           exons 5,6,7 same as 3a63-ps
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
           old name = Cyp3a44-se3[10] NW_037585.1|MmUn_WIFeb01_5425 
           3 diffs to 3a44
           same as CYP3A63-ps
649 AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK 
           old temp name = Cyp3attp 
           80% to 3a11 NW_008810.1|MmUn_WIFeb01_17679 
           one frameshift and small deletion same as CYP3a63-ps exon 11
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPS
YALHHHWPESEEFQPER
           Old name = CYP3A44-se1[12] NW_005077.1|MmUn_WIFeb01_14285 
           2 diffs with CYP3a44
1231 RFSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ 1067

Cyp3a63-ps AC114427.2 
This sequence is between 3a41a and 3a41b
Note: Cyp3a44-de12c has only one aa diff to this seq
63090 MNLFSALSLDTWILLAIILVLLYR 63019  probable beginning of pseudogene
YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK
GFWKFDMECYEKYGKTWG
LFDGQMPLFVITDP*MIKNVLVKECFSVFTNRR 
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
HRVDFLQLMMNAHNNSKDKDSHK 
AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPSYALHH(fs)HWPESEEFQPER
FSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ
IPLKLSRQGILQPEKPIVLKVVPRDAVITGA

The following sequences are bewtween 3a41a and 3a63-ps
(-)11231 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQV 11067
two sites have exact matches 145849323- 145849487 between 3a41a and 3a63-ps and 
146039664- 146039828 between 3a41b and 3a44
3 aa diffs (94%) to Cyp3a-se5[12] probably a poor quality seq match

Cyp3a-se12[8:9:10]
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
IVERTKENCLDSKQK
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10] 
(+)31398 SPVQMEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10

The following sequences are bewtween 3a63-ps and 3a41b
Cyp3a-se13[9]
76087 HQVDFLHLMINAHDKTKDKETHK 
identical to exon 9 of Cyp3a44-de9b10b11b12b includes old frag w from map

128725 RFSMENKGSIDPY 128763
128769 GPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQV 128876 = Cyp3a-se10[12]

CYP3A64     Macaca mulatta (rhesus monkey)
            No accession number
            Tom Rushmore, Merck & Co. Inc.
            Submitted to nomenclature committee 6/30/2003
            92% to CYP3A4

CYP3A65     Danio rerio (zebrafish)
            No accession number
            Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu, 
            Jun-Lan Wang-Buhler, and Donald R. Buhler
            Submitted to nomenclature committee 10/10/2003
            71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias, 
            69% to 3A30 Fundulus, 69% to 3A56 fundulus,
            56% to 3A37 chicken, 58% to 3A48 fugu  59% to 3A49 fugu, 45% to 3B2

CYP3A66X    Macaca mulatta (rhesus monkey)
            No accession number
            Brian A. Carr, Merck & Co. Inc.
            Submitted to nomenclature committee 4/22/2004
            91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
            name has been changed to indicate orthology = CYP3A5

CYP3A5      Macaca fasicularis (cynomolgus monkey)
            No accession number
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP3A5_2-F5
            3 aa diffs to 3A5 Macaca mulatta 

CYP3A67     Pan troglodytes (chimpanzee)
            No accession
            Eric Williams, Henry Strobel
            Recent gene duplication of CYP3A7

CYP3A67     Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a67
            96% to 3A67 chimp

CYP3A68  Large mouth bass
         DQ786406
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-a
         74% to CYP3A27 trout
MGYFFFFSAETWTLLVALITLIFVYVCWPFGTFKKMGVPGPRPI
PFFGTMLAYKKGFMHFDSECFKKYGKTWGIFDGRQPVLCITDPAMIKTVLIKECYSLF
TNRRNFRLNGELYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLISSM
KKTADKDEPLELKEFFGPYGMDVVTSTAFSVDIDSLNNPTDPFVANIKKMLKFDLFNP
IFLFIAFFPFMAPILEKLEFSFFPKSVLDFFYAALKKIKANRETTKLKNRVDFLQLMI
NSQKNNDLSKVENDKGLNDHEILSQAMIFLFAGYETTSSSLTFLAYNLARNPHVMKRL
QEEVDATFPNKAPVEYQALMQMEYLDSVVNESLRLYPIAPRLERVAKATVEINGLVIP
KGMVVMVPTWPLHRDPDLWPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRF
ALVLMKLAVVEILQTYSFSVCKETEIPIELDIQGLISPKRPIKLKLVPRSEPSN

CYP3A69X  Large mouth bass
         DQ786407
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-b
         64% to CYP3A47 Fugu
         note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR

CYP3A70  Macropus giganteus (Eastern grey kangaroo)
         No accession number
         Ross McKinnon
         Submitted to nomenclature committee Oct. 25, 2004
         65% to CYP3A4
         NOTE: THIS SEQ IS MOST LIKE RAT 3A9 compared to other rat 3As
         Therefore the 3A9 seq may be the oldest of the cluster in rats
         3A9 is orthologous to 3a13 in mouse.  Both sequences are on the 
         outside edge of the cluster.  

CYP3A71P  rat
          UCSC Browser chromosome 12
pseudogene 78% to 3A2 
9497641 LFEWHTPVFAITDREMIKNVLVKECFSVFTNWR 9497543 exon 4
9468424 DLGPMGIMNKSIAF*KDEEWKRYRALLSPMFTSGKLKV 9468311
9468234 MFPIIKLYGDILVKYLRQEAEKGKPVSVKE 9468145
9467886 IFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKFLRLDYFDPLFISV 9467737
9464756 GLFPFLKPIYDMLNISVFPKDSIAFFKNFVYSMKESHLDSKQK 9464631
9453844 YQVDFFQLMMNAHNNSSESHK 9453782
9451670 FPALSDIEIIAQSIIFTFGGYDTTSSTLSFVLYSLATHSDVQKKLQEEIDHALPNK 9451503
9449744 ASPTYDIVMEMEYLDMVFNETLRLYPVTGRLHRMCKKDIELDGVFIPKG
        SMVMIPLYPLQHDPQHWPEPEEFRPE 9449520
9447351 RFSKENKCRTGHYVYLPFGNGPRNCLGMRFALMSMKLAVTKVLQNFSFHPCKET 9447190
9444444 QIPLKLSKQVILKPEKPIVLKVVPRDGVING 9444352

CYP3A72    Balaenoptera acutorostrata (Minke whale)
           No accession number
           Iwata Hisato
           submitted to nomenclature committee 1/6/05 
           83% to CYP3A28 cow, 78% to 3A5 human, 75% to 3A5, 
           74% to 3A4, 71% to 3A43

CYP3A73    rat 
           chr12_random_1.5 (from UCSC browser)
           80% to 3A44 81% to 3A41 80% to 3A16 83% to 3A11 
           86% to 3A2 rat 
           this gene lies between Cyp3a85-ps and Cyp3a18
MDLVSALSLETWLLLAIILVLFYR (2)
FGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR (0)
GLWKFDMECYKKCGKIWG (2)
LFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR (0)
NIGPVGIMSKSISVAKDEEWKRYRAFLSPTFTSGRLKE (0)
MFPIIEHYGDILVKYLKQKVEKGKPLAMKE (2) 
VFGAYSMDVITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSV (1)
VLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHK (0)
HRVDFLQLMMNAHNNSKDKVSHK (1)
ALSDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNK (0)
APPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPER (2)
FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ (0)
IPLKLSRQRLFGPEKPIVLKVVPRDAVITGA*

CYP3A74     Bos taurus (cow)
            See cattle page for details
MELILSFSTETWVLLATGLVLLYL (2)
YGTYSYGLFKKLGVPGPRPLPYFGNILSYRK (0)
GVCEFNEECFKKYGKIWG (2)
IFEGKQPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDIKD (2)
IFGAYSMDVITSTSFGVNIDSLGNPQDPFVENVKKLLRFSILDPFLLAV(1)
VLFPFLVPILDVLNITIFPKSAVNFFTKSVKRIKESRLKDNQK(0)
PRVDFLQLMINSQNSKETDNHK  (1)
ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPEPEEFRPER (2)
FSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0)
IPLKISSQGVLRPEKPVVLKVVLRDGTISGA*

CYP3A75     Bos taurus (cow)
            See cattle page for details
MELIPSFSMETWVLLSISLVLLYL
YGTYSHGLFKKLGVPGPRPLPYFGNVLSYRK

VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSV
VLFPFLVPIFEVLNITMFPKSAVNFLAKSVKRIKESRLKDNQK
PRVDFLQLMINSQNSKETDNHK
ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDVTFPNK
APPTYDVLAQMEYLDMVVNETLRMFPITVRLDRLCKKDVKIHGVSIPKGTTVTVPISVLHRDPQLWPEPEEFRPER
FSKKNKDTISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKSCKETQ
IPLKINSQGLIRPEKPIFLKVVLRDETISGA*

CYP3A76     Bos taurus (cow)
            See cattle page for details
MELIPNFSVETWVLLAISLVLLYL(2)
YGTYSHGLFKKLGVPGPRPLPLFGNVLSYRK (0)
GVCEFDEECFKKYGKMWG (2)
IFEGKHPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPMGVMKNAVSVAEDEQWKRIRTLLSPTITSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDMKE (2)
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILDPFLLSV (1)
VLFPFLIPIFEVLNISIFPKSAVNFLTTSVKKIKESRLKDTQK (0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAVRLERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPELEEFRLER (2)
FSKKNKDSISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQ (0)
IPLKIKSQGLLRPEKPIFLKVVLRDETISGA*

CYP3A76-ie6b     Bos taurus (cow)
            See cattle page for details
            extra exon 6 SCAFFOLD300381 other exon 6 at 7654
9898 MFPIIGKYGDVLVRNLRKEAEKGKSVNMKE

CYP3A77    Alligator mississippiensis (alligator)
           GenEMBL AB186129
           Satomi Kohno
           Submitted to nomenclature committee Aug. 18, 2005
           54% to 3A48 Fugu, 57% to 3A27 trout, 61% to 3A5 human
           62% to ball python CYP3A42
           clone name CYP3A_AA

CYP3A78    Phascolarctos cinereus (koala, marsupial)
           No accession number
           Ross McKinnon
           Submitted to nomenclature committee July 29, 2005
           56% TO 3A4 AND 3A5, 77% TO OPOSSUM 3A (UNNAMED)

CYP3A79    Mediterranean sea bass 
           GenEMBL DQ268535 not yet available on Jan 4, 2006
           Pier Giovanni Gervasi
           Submitted to nomenclature committee Dec. 14, 2005

CYP3A80     Gallus gallus (chicken)
            GenEMBL XM_414782
            Note: chicken has two CYP3As about 25kb apart on chr 14
            See CYP3A37
MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPL
PFLGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTF
TNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNI
EKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNP
LLIFIVLFPFMIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMI
DSQSSQDSSKSAREKDSYKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKRLQDEIDANLPNKAAPTYNVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNG
VTIPKDMVVMIPAYVLHRDPAYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCI
GMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHSDP
QN

CYP3A80     Meleagris gallopavo (turkey) 
            No accession number
            Shirley Yip, Roger Coulombe, Jr.
            Submitted to nomenclature committee Jan. 20, 2006
            Clone name CYP3A-F2
            90% to chicken 3A80 probable ortholog

CYP3A80     Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80049345-80104701
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mdo1
            63% to CYP80A1 chicken (ortholog)
MTSYSGLSTETWTLLVAFVTLLILYGIWPYGIFKKLGIPGPRPLPFFGTFLEYRKGILEFDKQCFQKYGKMWGFYDGRLPIL
AILDPDIIKIVLVKEFYTLFTNRRNFGLNGILDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKV
AQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKMNLSLLSKENI
DFLVNASRRIIADRKKSNSRDRVDFLQLMIDSQVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLA
THPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQKTAEINGITIPKGTVMLIPVYVLHHD
PEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPK
KPIILKLVPRPRPDVED

CYP3A81     Xenopus tropicalis 
            See Xenopus pages for seq
            UCSC Browser scaffold_76:65898-87839 Aug. 2005 (xenTro2) assembly
            NM_001015786.1 59% to 3A5 from refseq database
            94% to 3A125, 92% to 3A122, 91% to 3A82, 88% to 3A123
MNLIPHLSTGTWILLAALLVLILLYGIWPYGYFKKMGIPGPTPL
PFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNF
TNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNI
QGYVEKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSP
LLILVVIFPFLRPILEGLNLNFVPKDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMM
DSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYETTSTALSYLFYNLATHPDVQQRL
HEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSKQNVEINGVSIP
KGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPFGDGPRNCIGLRF
ALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSRAAAHE

CYP3A82     Xenopus tropicalis 
            UCSC Browser scaffold_1918:6381-20049 Aug. 2005 (xenTro2) assembly
            BX779027 CX415432.1 93% to 3A81 N. Abdletawab
            CX415433 = mate pair
            Trace archive 243619963 419527443 418746304
            476067541 (exon 1)
            416306382 joint before I-helix
            98% to 3A122 (different scaffold, possible allele), 91% to 3A81, 
            89% to 3A123, 89% to 3A125
MNLIPHLSTGTWILLAVLLVLILL (2)
YGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR
MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPLESAITVAEDEQWKRIR
SVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDVITSTSFS
VNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFM
NAVTSFREKRKKGDHS (0)
GRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTALSYLF
YNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK
QNVEINGVIIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLPFGDG
PRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSRAAAHE*

CYP3A83     Xenopus tropicalis 
            CX982440.1 DT453227 
            UCSC Browser scaffold_320:299565-317579 Aug. 2005 (xenTro2) assembly
            60% to 3A80 chicken, 56% to 3A81 57% to 3A82
            96% to 3A120, 91% to 3A121, 89% to 3A124
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYKLFKRYGIPGPTPIPFIGTFL
GNRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLS
GPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNKEPLD
MKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVP
LLDKMNFCFLSLKILNFFKDAVASIKKKRQKGTH
EDRVDFLQLMVDAQSNEGKSVPEEEKHGYKE
LSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDA
LMKMEYMDMVINESLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHLNPEIWP
EPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCK
DTPVPLKICTKGYLKPTKPIILNLIPKVGQTVEE*

CYP3A84P   dog pseudogene between SDK1 and FOXK1 
           UCSC browser chr 6 
           The human pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
           are in a syntenic location with this pseudogene
16005702-16005782 (+) strand aa 47-73 exon 1
ISNTCCFLQGFCDFDEKCFRKYARTWG
16125771-16125865 (-) strand aa 74-105 exon 2
IIYRGRQPVLVILGSLLFMRVLVKEFYILFTNR
16124466-16124555 (-) strand 112-141 exon 5
XXXXXXGSLESSLIFAKGDKWNWLRTVISWTFASGK 
16119415-16119480 (-) strand 177-198 exon 7
GAFSRDVIISISFGVEADPISN
16044198-16044386 (+) strand 219-277
LFLSTIVFTFPALLLKLLNVIQLPKEGQEFFIGSISKMERKASERNLHSKQGLLVEKRQMFLN 
16113643-16113882 (-) strand aa 332-419 exon 11
IQEPLHKCLSLQQAAPTCEVLLQVEYLVTV*MTPSGSTSRGMSGRVWKKT
PEGMLVMITIYRLLRHPMHWLEPEESCPER

Cyp3a85-ps    rat
           GenEMBL NW_001084671.1 4655562-4666355 (-) strand
           86% to 3A2 new gene 
           (numbering is relative, taken from a larger sequence)
           missing first four exons on two different contigs
67133  DLGPLGIMSKAITFSKVEEWKRYRAFLSPTFTSGKLKE  67020
66942  MFPIVEQHGDILVKYLRREDEKGKPAPVKQ  66853
       VFGAYSMDEITSTSFGVSVD  66373
66372  FLTNPKDTFVEKTKKLLRFDFFDPLFLSVG
63877  LFPFLTPIYEMLNICMFPKDSIAFLQKFVYRMKETRLDSKHK
62887  HRVDFLQLMLNAHNNSKDEVSHK  62819
60567  ALSDVEIIAQSVTFIFAGYEITSSTLSFVLYSLATYPDIQKKLQEEIDGALPNK  60406
58571  APPTYDIVMEMEYLDMVLNETLRLYPVGNRLERVCKKDIELGGVFIPKGSVV  58416
58415  MIPTYPLQRDPQHWTEPEEFHPER  58344
56749  FSKENKGSIDPYVFLPFGHGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ  56588
53720  IPLKLSIQAILEPEKAIVLKVVPWDAVITGA  53628

CYP3A86    catfish
           No accession number
           David S. Barber, Margaret O. James
           76% to CYP3A65, 93% to CYP3A87
           intestine

CYP3A87    catfish
           No accession number
           David S. Barber, Margaret O. James
           76% to CYP3A65, 93% to CYP3A86
           liver

CYP3A88   Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          86% TO 3A22 AND 3A39v1, 76% to human 3A4 and 3A5
          partial seq.

CYP3A88   Sus scrofa (miniature pig) 
          3 aa diffs to CB479861.1 EST, probably the same seq.
          F22946.1 extends seq toward N-term.
          AJ959509.1 overlaps F22946 with 1 aa diff in 42
          Be aware this may be a hybrid of two or more gene sequences.
          BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
          DB799225.1
          92% to 3A39v1
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*

CYP3A89   horse
          No accession number
          Heather Knych
          Submitted to nomenclature committee June 22, 2007
          79% to 3A74 cow, 80% to CYP3A4 and CYP3A5 human
          80% to CYP3A39v1 pig

CYP3A89   horse
          UCSC Browser chrUn:228948991-228982779, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca2 
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYHKGIWDFDKKCFEKYGKMWGTYHGTKPVL
AITDPDMIKTVLVKECYSVFTNRRPFGPFGFMKSAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPILGQYGDVLVRNLKKEA
EKGKPITLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLFSFDFLDPLLLSITLFPFLNAVFEVLNVFVFPKSVT
DFFIKSVKRMKESRLKDKEKHRVDFLQLMINSQNSKELDTHKALSDLELVAQSIIFIFAGYETTSSSLSFLMYFLATHPDVQ
QKLQEEIDVTFPNKAPPTYDALVQMEYLDMVLNESLRLFPIAVRLERVCKKDVEINGVFIPKGTVVMVPTFALHKHPEFWPE
PEEFRPERFSKENKDSINPYIYLPFGAGPRNCIGMRFALMNMKLALVRMLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVSGA

CYP3A90     Callithrix jacchus (marmoset)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Cja3a5a
            87% to 3A5 human, paralog of CYP3A5

CYP3A91     Otolemur garnettii (galago)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oga1
            82% to 3A92, 79% to 3A98 dog, 79% to 3A4 human, 78% to 3A5 human

CYP3A92     Otolemur garnettii (galago)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oga2
            82% to 3A5 human, 83% to 3A4 human, 
            82% to 3A91, 80% to 3A98 dog

CYP3A93   horse
          UCSC Browser chrUn:228891415-228923288, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca1 
MDLIPSFSTETWVLLATSLVLIYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYRKGIWNFDRKCFKKYGKMWGVYDGRRPVL
AVTDPDMIKTVLVKECYSVFTNRRPFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLMVLFPFLQPIFEVLNISLFPKSAI
DFFTKSVKRMKESRLKDKDKHRVDFLQLMINSQNSKELDTHKGLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQ
QKLQEEIDAIFPNKAPPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFSLHRASEFWPE
PEEFRPERFSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVNGA

CYP3A94   horse
          UCSC Browser chrUn:229025212-229061564, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca3 
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYLKGFWDFDKKCFKKYGSMWGIYDGPQPVL
AITDPDMIKTVLVKECYSVFTNRRSLGPVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKET
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSITLFPFLKAVFEVIHIYMFPKRVT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQDEIDVTFPNKALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFILHRASEFWPE
PEEFCPERFSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKIGNQGLIQPQKPIVLK
VESRDGTWNGA

CYP3A95   horse
          UCSC Browser chrUn:229104699-229137172, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca4
MDLIPSLSMETWVLLATSLVLLYLYGTYSHGHFKKLGIPGPTPLPFFGTVLGYIKGVLAFDKKCFKKYGKMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKPITMKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSILFFPFLIPVYEALNIFVFPKCVT
DFFIKSVKKMKESRLKDKAKQRVDFLQLMINSQNSKEIDNLKVLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQ
QKLQEEIDATFPNKAPPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVLHQHPEFWSE
PEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQIPLKLVSQGLIRPEKPIVLK
VESRDGTMSGA

CYP3A96   horse
          UCSC Browser chrUn:229197172-229225636, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca5
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGFDTECLKKYRKMWGFYDGRQPVL
AITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEA
EKGKPIALKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFLFPKSVT
DFFTKSVKRIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQ
QKLQEEIDATFPNMAPPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFALHRDTELWPQ
PEEFHPERFSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQIPLKLVTYGFLQPEKPIVLK
VESRAGTVSGA

CYP3A97   horse
          UCSC Browser chrUn:229268263-229304613, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca6
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDFDKKCFKKYGKTWGFYEGRLPVL
AITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAIIRSEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEA
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISVFPKSVT
DFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQKEIDVTFPNKVPPTYDALLQMDYLDMVLNESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPE
PEEFRPERFSKENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTEAIVKPQKPIVLK
VEPRDGTMTGA

CYP3A98   Canis familiaris (dog)
          XP_536868.2 GenPept
          95% to CYP3A12, 91% to 3A26 
MDLIPSFSMETWLLLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGFSVFDENCFRKYGRMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENIKKLLKFDFLDPFFFSILLFPFLTPVFEVLNIWLFPKSVT
DFFTKSVKRMKENRLKDKQKHRVDFLQLMINSQNSKETDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQ
QKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE
PEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLK
VEPRDGSVNGA

CYP3A99   Canis familiaris (dog)
          XP_546969.2 GenPept
          95% to seq a + f from dog page, (exons 10, 11 do not match) 
          87% to 3A12, 85% to 3A26
MDLIPSFSTETWLLLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGFCDFDEKCFRKYGRMWGFYDGRQPVL
AIMDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSIILFPFLTPLYEMLNIWLFPKKIT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMNTHKALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQ
QKLQKEIDATFPNKAAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE
PEKFQPERFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILN
VEPRDGSVRGA

CYP3A100   Bos taurus (cattle)
           XP_584699.3 GenPept 
           95% to 3A74, 91% to 3A76, 80% to 3A28 
MELIPSFSMETWVLLSISLVLLYLYGTYSHGLFKKLGVPGPRPLPYFGNVLSYRKGVCEFDEECFKKYGKMWGIFEGKHPLL
VITDPDVIKTVLVKECYSVFTNRKVFGPRGIMKNAVSVAEDEQWKRIRTLLSPAFTSGKLKEMFPIIGKYGDVLVRNLRKEA
EKGKSVNMKEVFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSVVLFPFLVPILDVLNITIFPKSAV
NFFTKSVKRIKESRLKDNQKPRVDFLQLMINSQNSKETDNHKALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQ
QKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE
PEEFRPERFSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLK
VVLRDGTISGA

CYP3A101    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80414036-80431004
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo2
            89% to CYP3A102, 89% to 3A104, 89% to 3A103, 88% to 3A105, 69% to 3A89
IFTLPYRYGTRTHKLFKNLGIPGPTPLPFIGTVLSYHKGIEGFDYGCFKKYGKTWGFFDGTKPVLAIMDPETIKTVMVKECY
SVFTNRRMLGLSGILEKAISIAEDEQWKRMRTVLSPAFTGGKLKEMFPIIKQYGDVLVKNMKKEAEKSKPVTLKDILGAYSM
DVITSTSFGIHVDSLNNPNDPFVRKIRKLIRFSFRDPLILSIVIFPFLIPLFKKLDITIFSKDVTDFLAKSILKIKEERKKT
EKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYESTSSVLCFLFYQLATNPGIQEKLQKEIDAFLPNKEA
VTYDALVQMEYLDMVINENLRLYPITGRIERIAKKPVELNGLMIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKES
INPYVYLPFGVGPRNCLGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSYRPLLAPSVPIVLQAVLRNKKGNQH

CYP3A102    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80549861-80580975
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo3
            90% to 3A104, 89% to 3A103, 89% to 3A105, 89% to 3A101, 80% to 3A106
MNIIPNLSAGTWTLIILFLTILYLYGTRTHKLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVL
AIMDPETIKTVLVKECYSVFTNRRMLGLSGILEKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDAT
DFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLE
IQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYW
PEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIV
LQAVLRNKKGNQH

CYP3A103    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80611887-80640626
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo4
            99% to 3A105, 99% to 3A104, 89% to 3A102, 84% tpo 3A106
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A104    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80672879-80701151
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo5
            99% to 3A103, 98% to 3A105, 90% to 3A102, 89% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGILEKAISIAEDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERKKSTGKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A105    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80734341-80768989
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo6
            99% to 3A103, 98% to 3A104, 89% to 3A102, 88% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A106    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80783381-80814644
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo7 note: this seq has an assembly defect in the middle
            85% to 3A105, 84% to 3A103
MNIIPSLSAGTWTLIVVFLTLLYLYGTRTHKLFKNLGIPGPKPLPFFGTVFSYRKGLVNFDYDCFKKYGKTWGFYDGRQPVL
ATMDPETIKTVMVKECYSVFTNRRSFGPVGSLESAITVAKDDQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKNKPVTMKDILGAYSMDVITSTSFGIHVDSLNNPNDPFVREIKKLIRFNFLDPLILSVAIFPFLTPLFNKLDITVFPKDAI
NFLAKSLISMFSTIFSALVFILHYFFQHRVDLLQLMMDSQSSKNSEPHSHKDLSDQEILAQSIIFLFAGYETTSSVLSFLFY
HLATNPEIQEKLHKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLFPIAGRVERVAKKTVELNGLTIPKGTVVMTPPYVL
HREPEYWPEPEKFHPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMNMKVAVSRLLQEFSFRTCKETQVPLKLGNQPIL
TPTIPIVLQAELRNKKTN

CYP3A107    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25769723-25784944, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan1
            78% to CYP3A108, 75% to CYP3A109, 71% to CYP3A110, 57% to CYP3A113
MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGKIWRLFEGRQAMV
AVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSGKLKEMLRIMIHYGEILVKTIWKKA
EKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKLSSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSV
EYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQNPKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDV
QQKLQEEIDKVLPNKSPLTYDAIVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWT
EPDEFRPERFSKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPIVL
QFIPRADTKSQD

CYP3A108    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25741772-25760791, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan2
            79% to 3A109, 78% to 3A107, 75% to CYP3A110, 56% to 3A37 chicken
MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGKIWGLYEGRQAII
AVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSGKLKEMLPIMTHYGEVLVRNIWRKA
EKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKISSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSV
EYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQNPKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDV
QEKLQAEIDTVLPNKSPLTYDALVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWL
EPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPIVL
RYIPRADTKIKD

CYP3A109    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25693551-25724066, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan3
            79% to 3A108, 75% to 3A107, 77% to 3A110, 55% to CYP3A37 chicken
MSSILSFSIETWILLGTFLALMILYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKI
AVLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYGEVLVKNLQNKV
EKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALISVLPFMIPLLKLLNINTFPNDSV
EYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDV
QKKLQEEIDEVLPNKAPLTYDALVQMEYLDMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWV
NPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVL
RFIPRAEIKSKD

CYP3A110    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25660643-25688288, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan4
            77% to CYP3A109, 75% to 3A108, 71% to 3A107, 56% to 3A37 chicken
MRGILNFSIETWILLGSFLTLVILYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFDKKCFQKYGKIWGFYEGWKAKI
AVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRTLISSTFTSGKLKEMVPTIIHYGEILVKNIWYKA
EKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDRFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSV
EYFKRFMDNIKGTHHQGNQQQQVNFLQMMLDTQNPKEGSKAKGVLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDV
QQKLQEEIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHREPKYWL
EPDEFHPEIPLELTARGFLIPQKPIVLQFIPRAEIKKG

CYP3A111    Ornithorhynchus anatinus (platupus)
            UCSC Browser, Contig7638:3143-20297, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan5
            66% to CYP3A80 opossum (possible ortholog), 
            63% to 3A113, 60% to 3A80 chicken
GGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDI
DSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVDFLQLM
VDSQSSDSNSEPKMTDTEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDM
VVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPR
NCIGMRFALLNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED

CYP3A112    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:62196-70979, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca1
            84% to CYP3A113, 69% to CYP3A114, 66% to 3A80 chicken
            62% to CYP3A80 Monodelphis domestica, 60% to 3A37 chick
MDFFSFFSIQTWSLLGIFLLLLMLYGIWPYNFFKKLGIPGPRPLPFIGTFLEYNKGVLDFDERCRQKYGKIWGFFDGRQPVM
AIMDPVIIKTILVKECYTHFTNRRDFGLNGDFDASVLVAQDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGEMLVKNVQKKG
ENGEYIDTKDIFGAYSMDVITSTSFSIDIDSINNPKDPFVVSMKKIIKTNFVNPLLLLIVIFPFLRPVLEALNISLAPTSAT
GFLRGALRKIKSDRQKNVHQDRVDFLQLMVDSQISGDVFDGTNSYKALNDREILAQAFTFVFGGYETTSSTLGYMAYCLATH
PDVQKKLQDEIDEVLPDQATPVYDALLQMEYLDMVINETLRLYPPGGRIERVCKNTVEINGVTIPKGTVAMIPAFVLHRDPE
FWPEPEEFRPERFSKENKEFLNPYVFLPFGIGPRNCIGMRFALLSLKVATVVLMQRFSFRTCKETPIPLELESKGFMRPKNP
IRLKFVPRVMAESNE

CYP3A113    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:49268-57033, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca2 Browser is missing first exon in a seq gap
            84% to CYP3A112, 68% to 3A80 chicken, 72% to 3A114
            61% to 3A37 chick
GIWPYNFFKKLGIPGPRPLPFIGTFLEYRKGVLDFDEMCHKKYGKIWGFFDGREPVMAILDPVIIKTILVKECYTHFTNRRD
FGLNGDFDSSILTVQDEQWKRIRTVLSPNFTSGRLKEMFPIINHYGEMLVKNIQKKVENGEYIDTKDIFGAYSMDVITSTSF
SIDIDSINNPNDPFVTNIKKIVKFNFVNPLLVLIVIFPFLTPVLEALNFSLTPTSVTNFIKESIKKLKKDRQKNLHKDRVDF
LQLMVDSQISGEILDDSKSYKALNDKEILTQAIIFVFAGYETTSSTLSYMAYCLATHPDVQQKLQEEIDEALPNQATPVYEV
LLQMEYLDMVINETLRLYPPGGRIERVCKTTVEINGVTIPKGTVTMIPAFVLHRDPEFWPEPEEFRPERFSKENKETLDPYT
FLPFGAGPRNCIGMRFALLSLKVAMIVLLQRFSFRTCEETPIPLELQSQGFMTPKKPIRLKFVPRVMAESKE

CYP3A114    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:33297-45513, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca3
            72% to CYP3A113, 69% to 3A112, 61% to 3A80 chicken
            58% to 3A37 chick
YGIWPYNFFKKLGIPGPRPLPFIGTLHKHRIGVNNFDQKSHEKYGKIWGLFDGRQPVIAILDPAIIKIILVKHFYTHFTNRR
DFGLNGELDTSIAITRDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGKILVESAQKKVENGEAIDLKSFFGGYSMDVTTSTS
FSINVDSINNPNDPFVMHIKTFLKFDTFDPVILLVVIFPFLRPLFERLNFNMVAPSSFTTFFIDVLKKVKKDRQKNDHKNRV
DFLQLMVDSQISGNIPEEAKMYKALTDKEILTQAIVFIFAGFETTSTTLSFLSHCLATNPDVQQKLQEEIDATLPDQATPTY
NAIQQMEYLDMVVNETLRLYPVGGRIERDCKNTVEINGVTIPKGTVIVIPTFPLHRDPEYWPEPEEFRPERFSKENKETQNP
YVYLPFGAGPRNCIGMRFALLVVKVAIVVLLQKHTLRPCKETQIPLEVHGQVLLEPKKTIKLKLVRRAGLEE

CYP3A115    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:424-21366, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca5 partial seq
            54% to 3A37 chicken 
YGIWPYGVFKKLGVPGPTPLPFIGTALAYRNGILQFDKACFKKYGKVWGFYDGRTPVLAVTDPAVIKAVLVKECYTVFTNRR
KFGPTGKLEKAVSLAEDDTWKRIRTVLSPTFTSGKLKEMLPIIQHYAEILIKNFSEKADKGETVDIKDVLGPYSMDVVASSS
FGVNINSMNNPQDPFVKQAKKLVKFNFFSPLFVLMYMVPWLTPVLNKMNITLFSAEAVDFFAKAIGKIKEQRKQEMDKGRVD
FLALMIESQKAEAKTQINGMNQTYKFSKENKGRIDPYVYLPFGAGPRNCIGMRFAFLILKAGAVSLLQNFTFKPCKETQIPM
ELSTTGLMIPKKPIILKAIPRASSSH

CYP3A116    Dicentrarchus labrax (European sea bass)
            ABB90404.1 GenPept
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Dla3aX
            Possible Ortholog of CYP3A68
            87% to 3A68 bass
MGYFFYFSAETWTLLVTLITLFFVYVYWPYGTFKKMGIPGPKPIPFFGTMLAYRKGFMNFDSECFQKYGKTWGIYDGRQPVL
CITDVSMIKTVLIKECYSLFTNRRNFRLNGPLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFGIMKQHSANLISSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDLDSLNNPSDPFVTNIKKMLKFDLFSPLFLIVAFFPFMGPVFEKMEFSFFPTYVT
DFFYAALQKIKSNRETSKQKSRVDFLQLMIDSQKNNDLSGVEQDKGLNDHEILSQAMIFIFAGYETSSSSLTFLAYNLATNP
AVMKRLQQEIDSTFPNKAPIEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVELNGIVIPKDMVVMIPTWPLHRDPDL
WPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRFALVMMKLAIVEVLQRYSFSVCKETEVPFEMDIQGLLMPKRPI
KLKLEPRSEPSS

CYP3A117    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4870920-4874088, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33062
            Paralog of CYP3A68
            93% to 3A119, 93% to 3A118, 81% to 3A68 bass, 
            81% to 3A68 Dicentrarchus
MGFSLFLSAETWTLLVALVTLLFMYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFEGRQPVL
CITDPAMIKTILIKECYSLFTNRRNTRLNGQLHDALTVAENHQWRRIRSVLSPSFTSGKLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKLLNIDFFSPVFLIVAFFPFLGPIMEKMEFSLFPKSVT
DFFYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIVPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSL
WPEPEAFKPERFSKENKDSIDHYTYMPFGAGPRNCIGMRFALMMMKLAMVEILQRFSLSVCKETEIPLEMDTQAVVMPKRPI
KLKLVSR

CYP3A118    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4859354-4863677, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33063
            Paralog of CYP3A68
            95% to 3A119, 93% to 3A117, 83% to 3A68 bass
MGFSLFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGIPGPQPIPFFGTMLAYRKGITTFDEDCSKKYGKVWGIFDGRQPVL
CITDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDILSPLFLIVAFFPFLGPIMEKMEFSFFPKSVT
DFFYSALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIILRLERVAKATVEINGIVIPKDMVVAVPTWPLHRDPSL
WPDPEAFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVENLQRFSFSVCKETEIPLEMDVQDLLMPKRPI
KLKLVSR

CYP3A119    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4853058-4857963, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33064
            Paralog of CYP3A68
            95% to 3A118, 93% to 3A117, 87% to 3A68 bass, 
            86% to 3A68 Dicentrarchus
MGFFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFDGRQPVLCI
TDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKADK
DEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDFFSPVFLIVAFFPFMAPILEKMEFSFFPKSVTDF
FYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSSLSFLAYNLARNPHI
MKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSLWP
EPEAFKPERFSKENKDSIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVEILQRFSFSVCKETEIPLEMDVQGLLMPKRPIKL
KLVPR

CYP3A120    Xenopus tropicalis
            UCSC Browser scaffold_320:325056-341660, Aug. 2005 (xenTro2) assembly
            Huan Qiu
            Submitted to nomenclature committee May 30, 2007
            Xt3202
            96% identical to CYP3A83, adjacent on chr, 90% to 3A121
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRKGLMEFDMECFKKYGKVWGIYEGQKPLL
AIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEKHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNI
ATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKP
TKPIILNLIPKAGQTVEE

CYP3A121    Xenopus tropicalis 
            UCSC Browser scaffold_320:348830-370189 Aug. 2005 (xenTro2) assembly
            Huan Qiu
            Submitted to nomenclature committee May 30, 2007
            Xt3203 adjacent to CYP3A120, 91% to 3A83, 90% to 3A120, 88% to 3A124
MTFLPDFSKETWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRHGLMEFDMKCFKKYGNVWGFYDGPQPVL
AILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKMNFCFLSSKFL
KFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEEKHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNI
ARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKP
TKPIILNLVPKGAQTTEEQI

CYP3A122    Xenopus tropicalis
            UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
            98% to 3A82 (different scaffold, but possible allele)
            92% to 3A81, 90% to 3A123, 90% to 3A125
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE

CYP3A123    Xenopus laevis
            AAH60496.1 GenPept  
            90% to 3A122, 90% to 3A125, 89% to 3A82, 88% to CYP3A81
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE

CYP3A124    Xenopus laevis
            AAH84827.1 GenPept
            89% to 3A83, 89% to 3A120, 88% to 3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE

CYP3A125    Xenopus laevis
            AAI29607.1 GenPept
            94% to CYP3A81 (possible ortholog), 
            90% to 3A123, 90% to 3A122, 89% to 3A82
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE

CYP3A126    Pimephales promelas (Fathead minnow)
            No accession number
            Roger Meier
            Submitted to nomenclature committee Dec. 29, 2007
            81% to CYP3A65 Danio

CYP3A-se1[2]  human
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 2
           old name = CYP3A54P
           2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548

CYP3A-se2[5]  human
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 5
           old name = CYP3A55P
           2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579

mouse Cyp3a fragments of uncertain location

Cyp3a-se3[1] mouse
           NT_039319.1 
           new 3a frag from 1-24 exon 1 + strand
           v in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
           The true location of this fragment is uncertain
14293 MEPV (frameshift) FSSLTGYEWILLAIILVLLYR 14358

Cyp3a-se4[5:6]X mouse
           NT_071157.1|MmUn_71197_30 
           3a exons 5,6, only 3 aa diffs with 3a63-ps
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
           95% to 3a63-ps
549 EFGSVAIMSKAISISKDEECKRYRALLSPTFTSGRLKE 436
356 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 267

Cyp3a-se5[12]X mouse
           NT_071987.1|MmUn_72027_30 3a exon 12
           2kb genomic sequence near exon 12 has best match to 3a41a-de12b
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a41a-de12b
12194 FIKESKGNIHPYIYLPFGNGPRN*IGMRFALLNMKLTLTKVLQNFTFQPCKETQ 12033

Cyp3a-se6[12] mouse
           NT_055698.1|MmUn_55738_30 3a exon 12
           5 aa diffs with 3a58-ps
           identical to 3a11-de9b10b11b12b
           may be the same sequence between 3a44 and 3a11
1226 FSMENKGSIDPYX 1191
1186 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQ 1064

Cyp3a-se7[8:9:10]X mouse
           NT_067897.1|MmUn_67937_30 3a exon 8
           NT_059425.1|MmUn_59465_30 3a exon 10
5160 bp of the genomic sequence was 98.9% to 3a-se12[8:9:10] pseudogene region
The fragment was removed from Genbank. This was probably a poor quality version of 
3a-se12[8:9:10]
5042 FATFFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 4935
4933 IVERTKENCLDSKQK 4889
HQVDFLHLMINAHDNTKDNESHK
979 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLTHHDS*KNLRENDRALPNK 821

Cyp3a-se8[3]X mouse
           NT_070793.1|MmUn_70833_30 
           1 diff to 3a11 exon 3 or 3a63-ps
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
671 GFWKFDMECYKKYGKTWG 618

Cyp3a-se9[8]X mouse
           NT_050947.1|MmUn_50987_30 
           2 diffs to 3a41 exon 9
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
174 HRVDFLQLMMNAHNNSKDKNSHQ 106

Cyp3a-se10[12] mouse
           NT_050917.1|MmUn_50957_30 
           3a exon 12, 3aa diffs to 3a58-ps
521 FSMENKGSIDPYXXXXXX 486
483 NGPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQ 377

Cyp3a-se11[2]X mouse
           NT_074310.1|MmUn_74350_30 3a exon 12 
           2 diffs to 3a16, 3a41 3a44, 3a63
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
1107 YGTLTQGLFKKQGIPGPKPLPFLGTVLNYYK 1199

Cyp3a-se12[8:9:10] mouse
           NT_056284.1|MmUn_56324_30 
           3a exon 10
           revised to add two more exons 8 and 9
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10] 
(+)31410 MEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10

Cyp3a-se13[9] mouse 
           Between 3a63-ps and 3a41b in UCSC browser
76087 HQVDFLHLMINAHDKTKDKETHK 
identical to exon 9 of Cyp3a44-de9b10b11b and old frag w from map

Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]

CYP3A       sheep
            PIR A60728 (20 amino acids)
            Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
            Purification of a sheep liver cytochrome P-450 from the
            P450IIIA gene subfamily. Its contribution to the
            N-dealkylation of veterinary drugs.
            Biochem. Pharmacol. 39, 901-909 (1990)
            only one amino acid difference with CYP3A24   (L9K)

CYP3A       baboon (Papio sp.)
            Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
            Purification of two cytochrome P450 isozymes related to CYP2A
            and CYP3A gene families from monkey (baboon, Papio papio)
            liver microsomes. Cross reactivity with human forms.
            Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
            Eur. J. Biochem. 204, 641-648 (1992)

CYP3B1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2213a
6382   MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232   YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052   GIIPFESWCQAEYGDVWG 5999 (2)
       Exon 3 not detected may be in small seq. gap
5469   XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259   AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069  FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846   AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011  GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780   APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651  LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416  FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171   IPLEFDWKSQPLKPIKLSFIPRQK* 3097

CYP3B2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
 9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
 8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
 8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
 8214 HKDPRFWSSPEEFRPER 8164 (2)
      XXXXXXXXX in sequence gap 
      IELGTFMX frameshift
 8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
 7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734

CYP3B3      Oryzias latipes (medaka)
            UCSC Browser, chr15:14900678-14906425, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola1
            70% to 3B4, 67% to 3B7, 66% to 3B6, 67% to 3B1
MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNLNIPGPKPLPFVGTIFGVRKGLFAFDSECQAKYGDVWGLYDGRSPVLM
VADPEMIKTIMVKECYSVFTNRRETLIPGPFEDGITVVKDDRWKRIRSTISPCFTSGRLKQVFPIVASYADRLLKKLEQTNL
DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSEDPVNVHIQKLFNINFWPFILLMICPFAGRLLNSLNIGMLPKAESDFFL
NIIKKFKDQHKAGESTRQDFLQVMVQSEIPENEIKNEQEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHA
MHTLQKEIDANLQKNASFSYEELNDLHYLDQVILESMRVLPTAPRLERGCKKTVEIQGFTIPEGTVVGIPVMNLHKDPRYWS
SPELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLETCKDTLIPLQFDWKFQPLKPIKLKF
VPRKQ

CYP3B4      Oryzias latipes (medaka)
            UCSC Browser, chr15:14910843-14918605, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola2
            69% to 3B6, 70% to 3B3, 68% to 3B5, 66% to 3B7, 64% to 3B1
MFWSWFPGATWTLLALLLTILIFYGLWPYRVFKNLGISGPMPLPFVGTVPQQMKGLFAFNRECQAKYGDVWGLYEGRSPLLM
IADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMN
LNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWPMIIRMIFPLGARLLKHFKFEIIPRSSVDFF
CDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESEVKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPD
AMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQINGLTIPEGTVVGIPVHLLHRDPRFW
DSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWKFQPLKPIKLK
FVPRKR

CYP3B5      Oryzias latipes (medaka)
            UCSC Browser, chr15:14921023-14926010, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola3
            71% to 3B6, 68% to 3B4, 66% to 3B3, 62% to 3B7, 59% to 3B1
MLFLFSATTWTLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQQGKGFFEFDHECQTKYGDVWGVFEGRQPILMV
ADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVASAKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYL
NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQKATRFNFLPTILQSIIPFGGRLLKLFKIETLPSANVEFFI
DIIRNLKDQHKTENRPDFLQVLIESEMPDAEIKNSQQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMH
TLQKEIDSNLQKNSSISYEDLNGLEYLDQVINESLRLYPVAPRLDRECKMTVETQGFTVPEGMIVGIPVYLLHKDPRFWSSP
ELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQFNWMFQPIKPVKLKFVP
K

CYP3B6      Oryzias latipes (medaka)
            UCSC Browser, chr15:14927785-14936321, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola4
            69% to 3B4, 71% to 3B5, 66 to 3B3, 65^ to 3B7, 61% to 3B1
MFSATTWTLLALFFTVLLLYGVWPYRVFRKLGISGPMPLPFVGNVLQMGRDILSFDRQCLDKYGDVWGVFEGRQPMLMVANP
ELVKAVMVKECYSAFTNRRNFFPEDGPLADGVAVVKDEKWKRIRSSLTPCFTSGRLKQVYPLVARYAENLVKKLGRMNSDEP
IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPVNVQAQKATNFNFWPVILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLI
KRLRDQHKAGKLTRPDFLQVLIDSEIPQEHVKNEQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQ
KEIDSNLQNDGSFSYEELSGLEYLDQVLCESMRFFSPTPRLDRECKKTIEIHGVTIPKGTLVAIPVSLLHMDPRFWSSPEIF
RPERFSKENASELNPYAYMPFGLGPRNCVGMRFAVLVMKMVIVRLLQSYSLETCKDTLIPMQYDWQFQPIKPIKLKFVPRKQ

CYP3B7      Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrVI:13967807-13971259, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac49971
            68% to 3B1, 66% to 3B4
MFLFDWFPATSWTLLALFFTLLILYGIWPYRFFKNLGIKGPRPLPFIGTFLHFRKGWLSFDRECQAKYGDVWGNFDARLPVL
MVADPEIIKTVMVKECYSVFTNRRENAVPGPMGDAITAVKDERWKRIRTSLSPCFTSGRMKQVFPIVARYADRLTEKLGGMH
SVPIDVKQFMAPYSLDVVTSASFSVEANSINNPDDPLNVHLKNILNFKLWPVFILMVFPFGARLLRLLKLEMLDRVSVDYFY
DVIKHFKHQHGEDESTRADFLQVMIQNEIPDTDIKSEEDQPSKGLTEHEILSQALIFIFGGYETTSTTLTFLLYNLATNPDA
MRTLQEEIDANIPRDAPIRYEDLLGLQYLDQVLLESQRLIPTAPRLERVCKKTTQVHGLTIPKDTLVGIPVQLLHMDPRFWS
SPELFRPERFSKESGEEVNPYAYMPFGLGPRNCVGMRYAVLTMKTVLVRLLQSYNVETCKDTMIPLEFDWKAQPVQPVKLQF
VPREQ

CYP3C1      Danio rerio (zebrafish)
            GenEMBL BC052130.1 dated 10/7/2003
            Also submitted by Don Buhler 10/2/2003
            Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, 
            Chung WG, Buhler DR. CYP3C1, the first member of a new cytochrome 
            P450 subfamily found in zebrafish (Danio rerio).
            Biochem Biophys Res Commun. 2006 Feb 24;340(4):1039-46.
            52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49 
            53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout, 
            54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken, 
            48% to 3A29 pig (47% to 50% to many mammal 3As)

CYP3D1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold 600
            Formerly CYP3A47
      MNYLPLFALETWILLITFTCLFVM (2)
      YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
      NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
      IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
      FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQGASP (1)
      RCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
      EFDFLQHMISTQKNDGIYAVTS
  (1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
      LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
      FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
      IPFKMDPNTFVGPINPIKLRVVRR*

CYP3D1   Large mouth bass
         DQ786407
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-b
         Formerly CYP3A69 
         64% to CYP3A47 Fugu
         note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR

CYP3D1      Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4874663-4879489, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33061
            76% to 3D1 bass (ortholog), 61% to 3D1 Fugu, 
            58% to CYP3A119, 57% to 3A68 bass
MGCLPFFSVETWILLITFICIFVIYGNWTHGIFENLGIPGPKPYTYWGTIGRHNKVYYKDDQQCAEKYGKVWGMYEFRSPML
AVMDPDMLKTILVKQCFTYFTNRRNIRLNGDLYDSVSTVEDDHWRRIRNVLTPSFTSGHIKEMFKIMKHLSSKLTASLQSKA
QNNEVVTIKDYFGAYSVDVMASCAFSVDMDSINNHSSPIIFHASRFFKFPQFVLILQGIFPVLIPLFELLGISFFSPTSTAF
FKTILAKIKAEREGSTHKNSGDFLQSMINSRTANDPSKGEKNKGSLTDHEILTQATMFMVAGYETSATTLAFLAYNLARNPE
VMKRLQEEIDSTFPNKGAVRYEELLQMEYLDSVVNESMRLYPPAGRLDRVAKKTVEIRGITIPKDMIVMIPVYALHRDPDLW
PEPEEFKPDRFSKQNKRSINPYTYLPFGTGPRNCLGMRFALVLVKLALVEVLQNYSFSVCGETEIPLTMDPGGLVGPLNPIK
LKVTTR

CYP3E1      Hypsibius dujardini (water bear, Tardigrade)
            GenEMBL CK326870.1, CF075781
            David Drane
            3clan 38% CYP3A22 pig
            N-term only 
MWLAWLIGIVTALS
AYYIIAARRKFEYWQKKGVPGPRPWPLVGVFVQTVRMGQGFYDVWATKQFGRMFGYFDGS
QPVIAVSDPEMLRSIMVKDFPQFINRRDVDINGPLLEQAVSVLHGQKWKDVRSTLVPTFT
SGRLKQMNGLINECCDNLVSNLEKKADADEEFECQSLFRSVTMDVIASTFFG

4A Subfamily

CYP4A1      rat
            PIR S21711 (22 amino acids)
            Okita, R.T. and Okita, J.R.
            Characterization of a cytochrome P450 from Di(2-ethylhexyl)
            phthalate-treated rats which hydroxylates fatty acids.
            Arch. Biochem. Biophys. 294, 475-481 (1992)

CYP4A1      rat 
            Aldridge et al. 
            Biochem. J. 306, 473-479 (1995)
            note: identification of far upstream PPAR response element.

CYP4A1      rat
            GenEMBL M14972
            Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
            Isolation, complementary DNA sequence, and regulation of rat
            hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
            Identification of a new cytochrome P-450 gene family
            J. Biol. Chem. 262, 801-810 (1987)

CYP4A1      rat
            GenEMBL X07259
            Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
            Differential splicing in the 3' non-coding region of rat cytochrome
            P-452 (P450 IVA1) mRNA
            FEBS Lett. 236 (2), 357-361 (1988)

CYP4A1      rat
            GenEMBL M33937 M57718
            Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A gene subfamily I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
            DNA 8, 503-516 (1989)

CYP4A2      rat
            GenEMBL M33938 M57719
            Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A gene subfamily I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
            DNA 8, 503-516 (1989)

CYP4A3      rat
            GenEMBL M33936
            Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
            IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
            coordinate and tissue-specific regulation of the CYP4A genes
            DNA 8, 517-525 (1989)

CYP4A4      rabbit
            GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
            PIR S32423 (64 amino acids)
            Palmer,C.N., Griffin,K.J. and Johnson,E.F.
            Rabbit prostaglandin omega-hydroxylase (CYP4A4):
            Gene structure and expression.
            Arch. Biochem. Biophys. 300, 670-676 (1993)
            Note: The translation is different from the 4A4 sequence
            in the alignment after AALLG. A frameshift occurs between
            nucleotides 1201 and 1203, with an extra "G" added.  After 1320
            P450 similarity stops.  1320-1378 is an intron sequence.

CYP4A4      rabbit
            PIR JN0089 (20 amino acids)
            Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
            Kubota, I. and Kusunose, M.
            Purification and characterization of two forms of fatty acid
            omega-hydroxylase cytochrome P-450 from rabbit kidney
            cortex microsomes.
            J. Biochem. 108, 544-548 (1990)

CYP4A4      rabbit 
            GenEMBL J02818
            Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
            Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
            and Kusunose,M.
            cDNA cloning and inducible expression during pregnancy of the mRNA
            for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
            P-450p-2)
            J. Biol. Chem. 262, 13366-13371 (1987)

CYP4A5      rabbit
            GenEMBL M28655
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A5      rabbit
            GenEMBL X57209
            Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            cDNA cloning and expression of the mRNA for cytochrome P-450kd
            which shows a fatty acid omega-hydroxylating activity
            Eur. J. Biochem. 196 (3), 531-536 (1991)

CYP4A6      rabbit
            PIR S23949 (510 amino acids)
            Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
            Characterization of a rabbit gene encoding a
            clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
            Arch. Biochem. Biophys. 296, 66-72 (1992)

CYP4A6      rabbit
            PIR PQ0047 (20 amino acids)
            Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
            Purification and characterization of two forms of cytochrome
            P-450 with omega-hydroxylase activities toward
            prostaglandin A and fatty acids from rabbit liver
            microsomes.
            J. Biochem. 107, 280-286 (1990)

CYP4A6      rabbit 
            GenEMBL M29531 J05150
            Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            Two forms of omega-hydroxylase toward prostaglandin A and laurate:
            cDNA cloning and their expression
            J. Biol. Chem. 264, 21665-21669 (1989)

CYP4A6      rabbit
            GenEMBL M28656
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A6      rabbit
            GenEMBL L04755
            Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
            Characterization of a rabbit gene encoding a clofibrate-inducible
            fatty acid omega-hydroxylase: CYP4A6
            Arch. Biochem. Biophys. 296, 66-72 (1992)

CYP4A7      rabbit
            PIR JN0090 (20 amino acids)
            Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
            Kubota, I. and Kusunose, M.
            Purification and characterization of two forms of fatty acid
            omega-hydroxylase cytochrome P-450 from rabbit kidney
            cortex microsomes.
            J. Biochem. 108, 544-548 (1990)

CYP4A7      rabbit
            GenEMBL M29530 J05150
            Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            Two forms of omega-hydroxylase toward prostaglandin A and laurate:
            cDNA cloning and their expression
            J. Biol. Chem. 264, 21665-21669 (1989)

CYP4A7      rabbit
            GenEMBL M28657
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A8      rat
            PIR S08300 (15 amino acids)
            Imaoka, S., Nagashima, K. and Funae, Y.
            Characterization of three cytochrome P450s purified from
            renal microsomes of untreated male rats and comparison with
            human renal cytochrome P450.
            Arch. Biochem. Biophys. 276, 473-480 (1990)

CYP4A8v1    rat
            GenEMBL M37828
            Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
            Cloning and characterization of a novel member of the cytochrome
            P450 subfamily IVA in rat prostate
            DNA Cell Biol. 9 (8), 569-577 (1990)

CYP4A8v2    rat
            UCSC browser 
            This is the best match to M37828, but there are some differences
            especially in exon 6 (9aa diffs)
97% TO 4A8v1 M37828 chr5:135553023-135583411 (- strand) BC081771
CK483390.1 AGENCOURT EST matches
135583411 MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHK 135583223 (0)
135581811 IPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS 135581671 (1)
135581054 DPKSHHSYRFLAPWI 135581010 (1)
135580577 GYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIML 135580449 (0)
135558913 DKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDR 135558788 (2)
135558475 KYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 135558323 (1)
135557899 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135557792 (0)
135557703 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135557512 (2)
135557411 DDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK 135557280 (1)
135556361 GITVMLSFYGLHHNPTVWPNPE 135556296 (0)
135556143 VFDPYRFAPESSRHSHSFLPFSGGAR 135556066 (2)
135553187 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ 135553023

CYP4A8v2-de1b  rat
            UCSC browser
CYP4A exon 1 pseudogene chr5:135545150-135545338 (- strand)
Frag a in fig. below
135545338 MSIFELSHITTGFGISGLLQMVSWLGLLLLLLFKAAQYYLHRQWIIKSVQHFPSPPSHWFFGN 135545150
human, mouse and rat 4ABXZ clusters

CYP4A8v2-de5c6c12c  rat
            UCSC browser (upper line is the new sequence)
135596695-135596537 (- strand) C exon 5
Frag b in fig. below
Query: 37481 SVLLPQNKWE*TISDS---LEIFQCASLITLATILMCVFSY*DNVHLNRSVTSQSF 37639
             SV +  +KWE  + D    LEIF   SL+TL T++ C FS+  +V L+  V S+S+
Sbjct:   159 SVSIMLDKWE-KLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 211

135596212-135596066 (- strand) D exon 6
Query: 37964 HSQTYTQVVGILNNL-----RNAFPQSDIFYRMTADGHRTKNAFLIAHKHSDFV 38110
             +S++YT+ V  LNNL     R+AF  + I Y M++DG  ++ A  IAH+H+D V
Sbjct:   207 NSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 260

135594009-135593884 (- strand) E exon 12
Query: 40167 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 40292
             KQF MNE+KV + LTLL FE L DPTR+ V +   +L  + G
Sbjct:   454 KQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNG 495
human, mouse and rat 4ABXZ clusters

CYP4A8v2-de4d12d  rat
            UCSC browser (upper line is the new sequence)
135628319-135628215 (- strand) A exon 4
51% to 4A8 
Frag c in fig. below
Query:  5857 LSNDQTWFQHY*HI*TPLLHCDILKSNVRIVADCI 5961
             L N + WFQH   + TP  H DILK  V+I+AD +
Sbjct:   127 LLNGKKWFQHR-RMLTPAFHYDILKPYVKIMADSV 160

135617441-135617274 (- strand) B exon 12
75% to 4A2 76% to 4A8 
Query: 16735 RICIGKQLAMNAQKLAVALTLLQFELLPDPTRVPIPTEKLVLKSKNGIHLHLRKLQ 16902
             R CIGKQ AMN  K+AVALTLL+FELLPDPTR+P+P  +LVLKSKNGIHL L+KL+
Sbjct:   449 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR 504
human, mouse and rat 4ABXZ clusters

Cyp4a10     mouse
            GenEMBL X69296 (1887bp)
            Colin J. Henderson, Theo Bammler & C. Roland Wolf
            Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a 
            protein: developmental and hormonal regulation in liver and kidney
            Biochim. Biophys. Acta (1994) 1200, 182-190

Cyp4a10     mouse
            GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
            Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
            Species-specific induction of cytochrome P-450 4A RNAs: PCR 
            cloning of partial guinea-pig, human and mouse cDNAs.
            Biochem. J. 294, 173-180 (1993)

            GenEMBL Y10221 (exons 10-12)
            Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
            Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
            A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans.
            Biochem. J. 325, 741-749 (1997)
            Chromosomal assignment of this gene is given.

Cyp4a10     mouse
            GenEMBL AB018421
            Yasumura,N. and Ikeda,T.
            Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
            Unpublished (1998)

Cyp4a10     mouse