P450s that have appeared since the 1993 P450 nomenclature update.
This is part A of the list covering CYP1 to CYP2
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list.
This list was last revised on Jan. 31, 2003.
Added all human genes and pseudogenes
Compiled by David R. Nelson
A new format is being designed to make the entries more useful, with links to
Genbank and Medline and access to the protein sequence. As time permits the
entries in the 1993 P450 Nomenclature Update will be added to make the
listing more comprehensive. For the time being, I will leave the old text
format in place below the newer table format, but eventually the text version
will be deleted. Any comments are welcome.
1A Subfamily
1B Subfamily
2A Subfamily
2B Subfamily
2C Subfamily
2D Subfamily
2E Subfamily
2F Subfamily
2G Subfamily
2H Subfamily
2J Subfamily
2K Subfamily
2L Subfamily
2M Subfamily
2N Subfamily
2P Subfamily
2Q Subfamily
2R Subfamily
2S Subfamily
2T Subfamily
2U Subfamily
2V Subfamily
2W Subfamily
2X Subfamily
2Y Subfamily
2Z Subfamily
2AA Subfamily
2AB Subfamily
2AC Subfamily
2AD Subfamily
2AE Subfamily
2AF Subfamily
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Cytochrome P450 Data CYP1 to CYP2 (Under Construction) |
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P450 gene |
Species |
Medline Entry |
Comment |
Protein Sequence |
Genbank Accession |
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CYP1A1 |
human |
none |
3' UTR |
D12525 D01198 |
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CYP1A1 |
human |
none |
3' UTR |
D12525 D01198 |
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CYP1A1 |
human |
none |
3' UTR |
D12525 D01198 |
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CYP1A1 |
human |
none |
5' UTR |
D10855 D01150 |
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CYP1A1 |
human |
none |
5' UTR |
D10855 D01150 |
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CYP1A1 |
Cavia cobaya |
none |
D11043 PIR S43414 |
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1A Subfamily
CYP1A1 human
GenEMBL D12525 D01198 (650bp)
Kawajiri,K., Watanabe,J., Gotoh,O., Tagashira,Y., and Sogawa,K.
Structure and drug inducibility of the human cytochrome P-450c
gene.
Eur. J. Biochem. 159, 219-225 (1986)
Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
Xenobiotic responsive element in the 5'-upstream region
of the human P-450c gene.
J. Biochem. 110, 232-236 (1991)
Hayashi,S.-i., Watanabe,J., Nakachi,K. and Kawajiri,K.
Genetic linkage of lung cancer-associated MspI polymorphisms
with amino acid replacement in the heme binding region of
the human cytochrome P450IA1 gene.
J. Biochem. 110, 407-411 (1991)
CYP1A1 human
GenEMBL D10855 D01150 (4144bp)
Kawajiri,K., Watanabe,J., Gotoh,O., Tagashira,Y., and Sogawa,K.
Structure and drug inducibility of the human cytochrome P-450c
gene.
Eur. J. Biochem. 159, 219-225 (1986)
Kubota,M., Sogawa,K., Kaizu,Y., Sawaya,T., Watanabe,J.,
Kawajiri,K., Gotoh,O. and Fujii-Kuriyama,Y.
Xenobiotic responsive element in the 5'-upstream region
of the human P-450c gene.
J. Biochem. 110, 232-236 (1991)
Note: these refs are the same as the two earlier accession numbers.
CYP1A1 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
94% to CYP1A1 human, 73% to CYP1A2 human, ortholog of CYP1A1
CYP1A1 Cavia Cobaya (guinea pig)
GenEMBL D11043 (2674bp)
PIR S43414 (516 amino acids)
Ohgiya,S. Ishizaki,K. and Shinriki,N.
Molecular cloning of guinea pig CYP1A1: complete primary structure
and fast mobility of expressed protein on electrophoresis.
Biochim. Biophys. Acta 1216, 237-244 (1993)
CYP1A1 rat
GenEMBL I00732 (1800bp)
Oeda,K., Sakaki,T., Ohkawa,H., Yabusaki,Y., Murakami,H.,
Nakamura,K. and Shimizu,M.
Cytochrome P-450MC gene, expression plasmid carrying the said gene,
yeasts transformed with the said plasmid and a process for producing
cytochrome P-450MC by culturing the said transformant yeasts.
Patent: US 4766068-A 1 23-AUG-1988
CYP1A1 rat
PIR A93513 (524 amino acids)
Yabusaki, Y., Shimizu, M., Murakami, H., Nakamura, K., Oeda,
K. and Ohkawa, H.
Nucleotide sequence of a full-length cDNA coding for
3-methylcholanthrene-induced rat liver cytochrome P-450MC.
Nucleic Acids Res. 12, 2929-2938 (1984)
CYP1A1 rat
PIR S45716 (524 amino acids)
Omata, Y., Robinson, R.C., Gelboin, H.V., Pincus, M.R.,
Friedman, F.K.
Specificity of the cytochrome P-450 interaction with
cytochrome b(5).
FEBS Lett. 346, 241-245 (1994)
CYP1A1 rat
PIR D60822 (19 amino acids)
Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
Oesch, F.
Effect of nutritional imbalances on cytochrome P-450 isozymes
in rat liver.
Biochem. Pharmacol. 37, 3245-3249 (1988)
CYP1A1 hamster
GenEMBL D10913 (8700bp) Swiss Q00557 (524 amino acids)
Sagami,I., Ohmachi,T., Fujii,H., Kikuchi,H. and Watanabe,M.
Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in
lung and liver: cDNA cloning and sequence analysis
J. Biochem. 110, 641-647 (1991)
CYP1A1 hamster
PIR JS0746 (524 amino acids)
Ohgiya, S., Goda, T., Ishizaki, K., Morimoto, M., Sakamoto,T.,
Kamataki, T. and Shinriki, N.
unpublished (1992)
CYP1A1 rabbit
PIR A25143 (464 amino acids)
Okino, S.T., Quattrochi, L.C., Barnes, H.J., Osanto, S.,
Griffin, K.J., Johnson, E.F. and Tukey, R.H.
Cloning and characterization of cDNAs encoding 2,3,7,
8-tetrachlorodibenzo-p-dioxin-inducible rabbit mRNAs for
cytochrome P-450 isozymes 4 and 6.
Proc. Natl. Acad. Sci. U.S.A. 82, 5310-5314 (1985)
CYP1A1 Macaca irus (crab eating macaque monkey)
GenEMBL D17575 (2602bp)
Ohmachi,T., Sagami,I., Kikuchi,H., Fujii,H., Suzaki,Y., Fujiwara,T.
and Watanabe,M.
Molecular cloning and sequence analysis of cDNA encoding a
crab-eating monkey (Macaca irus) cytocrome P-450
unpublished (1993)
CYP1A1 Macaca fasicularis (crab eating macaque monkey)
Swiss P33616 (512 amino acids)
Komori, M. Kikuchi,O. Kitada,M. Kamataki T.
Molecular cloning of monkey 1A1 cDNA and expression in yeast.
Biochim. Biophys. Acta 1131, 23-29 (1992)
CYP1A1 Sus scrofa (pig)
GenEMBL AB052254
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
82% to human CYP1A1, 74% to human 1A2
CYP1A1 Ovis aries (sheep)
GenEMBL S79795 (2585bp)
Hazinski,T.A., Noisin,E., Hamon,I. and DeMatteo,A.
Sheep lung cytochrome P4501A1 (CYP1A1): cDNA cloning and
transcriptional regulation by oxygen tension
J. Clin. Invest. 96 (4), 2083-2089 (1995)
CYP1A1 Bos taurus (cow)
See cattle page for details
MFSVFGLPIPISATELLLASAVFCL
VFWVVRTWRPRVPQGLKSPPEPWGWPLLGHMLMLGKNPHVVLSQLSQRYGDVLQIRIG
CTPVLVLSGLDTVRQALVRQGDDFKGRPDLYSFTLITNGQSMTFNPDSGPVWAARRRL
AQNALKSFSTASDPASSSSCYLEEHVNKEAKYLLGKFQELMSGPGRFDPYRYIVVSVA
NVICAICFGRRYDHNDQEFLSLVNLSNEFGEITASGNPSDFIPVLRYLPNTALDLFKD
LNQRFYVFVQKIVKEHYKTFEKGHIRDITDSLIEHCQDKRLDENANIQLSDEKIINVV
IDLFGAGFDTVTTALSWSLLYLVTSPRVQKKIQEELDTVIGRARRPRLSDRPQLPYLE
AFILETFRHSSFVPFTIPHSTTRDSNLNGFYIPKGRCVFVNQWQINHDQKLWEDPSEF
RPERFLTADGTINKVLSEKVIIFGLGKRKCIGETIARLEVFLFLAILLHQVEFCVTPG
VKVDMTPVYGLTMKYARCEHFQAHMRS
CYP1A1 Canis familiaris (dog)
AACN010067442.1 Canis familiaris ctg19866850684014,
79% to 1A1 human N-term
AACN010089968.1 Canis familiaris ctg19866851895459,
84% to 1A1 C-term
full length combined seq = 81% to 1A1
1868 MFRLSIPISASELLLASTVFCLVLWVVKAWQPRLPKGLKSPPGPWGWPLLGNVLTLGKSPHLALS 2062
2063 RLSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGDDFKGRPDLYSFSLVTDGQSLTFS 2242
2243 PDSGPVWAARRRLAQNALKSFSIASDPASSCSCYLEEHVSKEAEVLLSRLQEQMAEVGRF 2422
2423 DPYRYIVVSVANVICAMCFSKRYDHDDQELLSLVNLSNEFGEGVASANPLDFFPILRYLP 2602
2603 NPALDFFKDLNKRFYSFMQKMVKEHYKTFEK 2695
133 GQIRDVTDSLIEHCQDKRLDENANIQLSDEKIVNVVLDLFGA 258
347 GFDTVTTAISWSLLYLVTNPNVQKKIQKEL 436
529 DTVIGRARQPRLSDRPQLPYMEAFILETFRHASFVPFTIPH
STTRDTSLSGFYIPKGRCVFVNQWQINHDQ 885
1038 KLWGNPSEFQPERFLTLDGTINKALSEKVILFGLGKRKCIGETIARLEVFLFLAILLQQ 1217
1218 VEFSVPEGTKVDMTPIYGLTMKHARCEHFQVRVRTEGAERSAA* 1349
CYP1A1 horse
No accession number
Heather Knych
Submitted to nomenclature committee Oct. 14, 2007
80% to CYP1A1 human, 70% to CYP1A2 human
CYP1A1 Macropus eugenii (tamar wallaby)
no accession number
Ross McKinnon
submitted to nomenclature committee 9/7/98
98 amino acid C-terminal fragment is 82% identical to macaque 1A1
CYP1A1 Monodelphis domestica (opossum)
UCSC Browser Oct 2006 assembly chr1 23141664- 23146346 (-) strand
Syntenic with human CYP1A1 adjacent to EDC3 and CYP1A2
73% to 1A1 hum 65% to 1A2 hum Built_from_P56591_and_others
489177 - 493862 bp (489.2 Kb) on chromosome fragment scaffold_14927
This transcript is located in sequence: contig_43733
MTSILSLLGFSKSFTVTELLVVSAVFCLVFWIIDSYHQRVPKGFKSPPGPWAWPLIGNVL
TLGKNPHLVLTQMREKYGDVMQIQIGSTPVLVLSGLETIRHALVKQGDDFKGRPDLYSFS
LILDGESLSFGPDSGEVWAARRKLTQNALKAFSISSSPSSSFCYLEEHVIKEAEYLIQKF
QEQKGHFDPVRYIVVSVANVICAICFGQRYDHDDQELLNIVRLSNKFGEVAASGNPVDFI
PILRYLPNSKITAFRDLNEKIVAFTQKLVKEHYRKFEKGCIRDITDSLIEHCQEKKLDEN
ANIMLSEKKVVNVVIDLFGAGFDTVTTAISWGLMYLVAKPEVQKKIHEELDTVIGRERLP
QLSDKTQLPYMEAFILETFRHSSFLPFTIPHSTTRDITLNGFYIPKGRCVFVNQWQINHD
PKIWGDPSVFRPERFLSVDGTINKALSEKVIMFGLGKRKCIGETIARWEVFLFLSILLHR
MEFSVPSGVKVDLTPVYGLTMKHIPCEHFQTKLRS
CYP1A1 Balaenoptera acutorostrata (Minke whale)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP1A1 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
82% to CYP1A1 human, 74% to CYP1A2
CYP1A1 Pusa sibrica (Baikal seal)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
82% to CYP1A1 human, 75% to CYP1A2
CYP1A1 Phocoenoides dalli (Dall's porpoise)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP1A1 Eumetopias jubatus (Steller sea lion)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
clone #1
submitted to nomenclature committee 5/15/98
CYP1A1 Phoca largha (Spotted seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP1A1 Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 6/29/99 revised 2/27/01
CYP1A1 Halichoerus grypus (grey seal, gray seal)
No accession number
Rachel Tilley
Submitted to nomenclature committee 3/19/2001
Name grey seal 1
CYP1A1 Phoca groenlandica (harp seal)
No accession number
Rachel Tilley
Submitted to nomenclature committee 3/19/2001
Name harp seal 1
Cyp1a1 mouse
GenEMBL K02588 (2619bp)
Kimura,S., Gonzalez,F.J. and Nebert,D.W.
The murine Ah locus.
J. Biol. Chem. 259, 10705-10713 (1984)
Cyp1a1 mouse
GenEMBL M10021 (8809bp)
PIR A24953 (30 amino acids)
Gonzalez,F.J., Mackenzie,P.I., Kimura,S. and Nebert,D.W.
Isolation and characterization of full-length mouse cDNA and
genomic clones of 3-methylcholanthrene-inducible cytochrome
P-1-450 and P-3-450
Gene 29, 281-292 (1984)
Cyp1a1 mouse
GenEMBL X01681 (6214bp)
Kimura,S., Gonzalez,F.J. and Nebert,D.W.
The murine Ah locus: Comparison of the complete cytochrome P1-450
and P3-450 cDNA nucleotide and amino acid sequences
J. Biol. Chem. 259, 10705-10713 (1984)
Cyp1a1 mouse
GenEMBL M11515 (8850bp)
Kimura,S. and Nebert,D.W.
Comparison of the mouse P-1-450 gene and flanking sequences from a
MOPC 41 plasmacytoma and normal liver.
DNA 4, 365-375 (1985)
Cyp1a1 mouse
GenEMBL M25623 (410bp)
Peterson,T.C., Gonzalez,F.J. and Nebert,D.W.
Methylation differences in the murine P-1-450 and P-3-450 genes in
wild-type and mutant hepatoma cell culture
Biochem. Pharmacol. 35, 2107-2114 (1986)
Cyp1a1 mouse
GenEMBL M33935 (474bp)
Jones,J.E. and Nebert,D.W.
Transcriptional start site in the mouse Cyp1a1 (cytochrome P-1-450) gene.
DNA 8, 527-534 (1989)
Cyp1a1 mouse
PIR C24406 (24 amino acids)
Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
Gelboin, H.V. and Friedman, F.K.
Amino-terminal sequence and structure of monoclonal antibody
immunopurified cytochromes P-450.
Biochemistry 25, 2397-2402 (1986)
CYP1A1 Xenopus tropicalis (frog)
CYP1A2 human
GenEMBL M38504 (3149bp)
Jaiswal,A.K., Nebert,D.W., McBride,W.O. and Gonzalez,F.J.
Human P-3-450: cDNA and complete protein sequence, repetitive Alu
sequences in the 3' nontranslated region, and localization of gene
to chromosome 15
J. Exp. Pathol. 3, 1-17 (1987)
CYP1A2 human
GenEMBL U02993 (3293bp)
Quattrochi,L.C. and Tukey,R.H.
The human cytochrome Cyp1A2 gene contains regulatory elements
responsive to 3-methylcholanthrene
Mol. Pharmacol. 36, 66-71 (1989)
CYP1A2 human
PIR A25892 (515 amino acids)
Quattrochi, L.C., Pendurthi, U.R., Okino, S.T., Potenza, C. and
Tukey, R.H.
Human cytochrome P-450 4 mRNA and gene: part of a multigene
family that contains Alu sequences in its mRNA.
Proc. Natl. Acad. Sci. U.S.A. 83, 6731-6735 (1986)
CYP1A2 human
PIR A60881 (18 amino acids)
Wrighton, S.A., Campanile, C., Thomas, P.E., Maines, S.L.,
Watkins, P.B., Parker, G., Mendez-Picon, G., Haniu, M.,
Shively, J.E., Levin, W. and Guzelian, P.S.
Identification of a human liver cytochrome P-450 homologous
to the major isosafrole-inducible cytochrome P-450 in the rat.
Mol. Pharmacol. 29, 405-410 (1986)
CYP1A2 Macaca fascicularis (cynomolgus monkey)
GenEMBL D86474
Sakuma,T., Hieda,M., Igarashi,T., Ohgiya,S., Nagata,R., Nemoto,N.
and Kamataki,T.
Molecular cloning and functional analysis of cynomolgus monkey
CYP1A2
Biochem. Pharmacol. 56 (1), 131-139 (1998)
CYP1A2 Macaca fuscata (Japanese macaque)
GenEMBL AB185338 (hold till 7/22/2005)
Shizuo Narimatsu
Submitted to nomenclature committee 8/28/2004
99% identical to cynomolgus monkey CYP1A2
92.4% to human CYP1A2
CYP1A2 rabbit
PIR B27821 (516 amino acids)
Kagawa, N., Mihara, K., Sato, R.
Structural analysis of cloned cDNAs for polycyclic
hydrocarbon-inducible forms of rabbit liver microsomal
cytochrome P-450.
J. Biochem. 101, 1471-1479 (1987)
CYP1A2 dog
PIR A60463 (16 amino acids)
Ohta, K., Motoya, M., Komori, M., Miura, T., Kitada, M. and
Kamataki, T.
A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is
a low spin form of cytochrome P-450 but with catalytic and
structural properties similar to P-450d.
Biochem. Pharmacol. 38, 91-96 (1989)
CYP1A2 Canis familiaris (dog)
UCSC Browser chr30:40816888-40821608 (+) strand May 2005 assembly
AACN010103563.1 Canis familiaris ctg19866850724666,
90% to 1A2
AACN010517076.1 Canis familiaris ctg19866850724664,
82% to 1A2 human N-term
AACN010004324.1 Canis familiaris ctg19866850196532,
86% to 1A2 C-term
combined sequence for 1A2
362 MALSQMATELLLASTIFCLILWVVKVWQPRLPKGLKSPPGPWGWPLLGNVLTLGKSPHLALS 177
176 RLSQRYGDVLQIRIGSTPVLVLSSLDTIRQALVRQGDDFKGRPDLYSFSLVT
DGQSLTFSPDSGPVWAARRRLAQNALNTFSIASDPASSCSCYLEE 771
770 HVSKEAEALLSRLQEQMAEVGRFDPYNQVLMSVANVIGAMCFGHHFSQRSEEMLPLLMSS 591
590 SDFVETVSSGNPLDFFPILQYMPNSALQRFKNFNQTFVQSLQKIVQEHYQDFDE 429
RSVQDITGALLKHNEKSSRASDGHIPQEKIVNLINDIFGA
GFDTVTTAISWSLMYLVANPEIQRKIQKEL
DTVIGRARQPRLSDRPQLPLMEAFILEIFRHTSFVPFTIPHS (2)
631 TTKNTTLKGFYIPKECCVFINQWQVNHDQ 717
1789 QVWGDPFAFRPERFLTADGTAINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 1968
1969 RLEFSVPAGVRVDLTPIYGLTMKHTRCEHVQARPRFSIK* 2088
CYP1A2 Bos taurus (cow)
See cattle page for details
MALSQLSPFSAMELLLASAIFCLVFWVVRTWRPRVPQGLKSPPEPWGWPLLGHMLTLG
KNPHVVLSQLSQRYGDVLQIRIGCTPVLVLSGLDTVRQALVRQGDDFKGRPDLYSFTLVT
DGQSMTFNPDSGPVWAARRRLAQNALNTFSVASD
PSSSSSCYLEDHVSKEAEALLGKFQELMSGPGRFDPYGHVVASV
ANVIGAMCFGQHFPQSSKEMLSLVESSHDFVESASSGNPVDFFPILKYLPNPALQRFK
SFNQRFLQFVRKTVQEHYQDFDKNSIQDIIGALFKHSEDNSRASSRLISQEKTVNLVN
DLFAAGFDTITTAISWSLMYLVTNPKIQRKIQEELD
RVVGRARRPRLSDRPQLPYLES
FILETFRHSSFVPFTIPHSTTRDTTLNGFFIPKERCVFINQWQVNHDPKLWGDPSVFR
PERFLTSDGTTIDKTASEKVLLFGMGKRRCIGEVMARWEVFLFLAILLQRLEFSVPPG
VKVDLTPTYGLTMKHARCEHMQARLRFPIK
CYP1A2 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
86% to 1A2hum, 75% to 1A1hum
partial seq.
CYP1A2 Sus scrofa (miniature pig)
GenEMBL CB483208.1
KLWGDPSEFRPERFLTADGTAIHKTMSEEVILFGMGKRRCIGEVLAKWEVFLFLAILLQQ
LEFSVPP
CYP1A2 rat
PIR B24406 (25 amino acids)
Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
Gelboin, H.V. and Friedman, F.K.
Amino-terminal sequence and structure of monoclonal antibody
immunopurified cytochromes P-450.
Biochemistry 25, 2397-2402 (1986)
CYP1A2 rat
GenEMBL X01031 (1106bp) PIR A44612 (367 amino acids)
Yabusaki, Y., Murakami, H., Nakamura, K., Nomura, N.,
Shimizu, M., Oeda, K. and Ohkawa, H.
Characterization of complementary DNA clones coding for two
forms of 3-methylcholanthrene-inducible rat liver
cytochrome P-450.
J. Biochem. 96, 793-804 (1984)
CYP1A2 rat
PIR S26822 (19 amino acids)
Botelho, L.H., Ryan, D.E., Yuan, P.M., Kutny, R., Shively,
J.E. and Levin, W.
Amino-terminal and carboxy-terminal sequence of hepatic
microsomal cytochrome P-450d, a unique hemoprotein from
rats treated with isosafrole.
Biochemistry 21, 1152-1155 (1982)
CYP1A2 rat
PIR D60822 (22 amino acids)
Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
Oesch, F.
Effect of nutritional imbalances on cytochrome P-450 isozymes
in rat liver.
Biochem. Pharmacol. 37, 3245-3249 (1988)
CYP1A2 rat
PIR A61400 (513 amino acids)
Woelfel, C.; Platt, K.L.; Dogra, S.; Glatt, H.; Waechter, F.;
Doehmer, J.
Stable expression of rat cytochrome P450IA2 cDNA and
hydroxylation of 17beta-estrodiol and 2-aminofluorene in
V79 Chinese hamster cells.
Mol. Carcinog. 4, 489-498 (1991)
CYP1A2 hamster
GenEMBL D10914 (9719bp)
Sagami,I., Ohmachi,T., Fujii,H., Kikuchi,H. and Watanabe,M.
Hamster cytochrome P-450 IA gene family, P-450IA1 and P-450IA2 in
lung and liver: cDNA cloning and sequence analysis
J. Biochem. 110, 641-647 (1991)
CYP1A2 Mesocricetus auratus (hamster)
GenEMBL M63787 M34446 (1868bp)
Lai,T.S. and Chiang, J.Y.L.
Cloning and characterization of two major 3-methylcholanthrene inducible hamster
liver cytochrome P-450s.
Arch. Biochem Biophys. 283, 429-439 (1990)
clone MC4
note: M34446 is incorrectly included in the GenBank entry
for CYP2A8 and CYP2A9. M34446 should only be in the CYP1A2 hamster entry.
CYP1A2 Cavia cobaya (guinea pig)
GenEMBL D50457 (1760bp)
Mori,T., Itoh,S., Ohgiya,S., Ishizaki,K. and Kamataki,T.
Effect of ascorbic acid on expression of several forms of
cytochrome P-450 of guinea pig
Unpublished (1995)
CYP1A2 Cavia porcellus (guinea pig)
GenEMBL U23501 (1757bp)
Black,V.H.
unpublished 1995
CYP1A2 Monodelphis domestica (opossum)
UCSC Browser Oct 2006 assembly chr1 23173195 - 23183937 (+) strand
Syntenic with human CYP1A2 adjacent to CYP1A1 and CSK
70% to 1A2, 65% to 1A1 Built_from_Q64391_and_others
451687 - 462429 bp (451.7 Kb) on chromosome fragment scaffold_14927
This transcript is located in sequence: contig_91822
MVSSLLASISISELLLASVIFCLVFWVTRSSHQRVPKGLKSPPGPWAWPLFGNVWTLGKN
PHLTLAQLSEKYGDVMKIHIGSTPVIVLSGLETIRQALVKQGEDFKGRPDLYSSTFVADG
YSLAFNPDSGEVWAVRRKLAQNALNTFSVSSSPSSSSCYLEEHVNKEVKHLIQKFQELME
GVGCFDPYRHIVASVANVISAMCFSQRYEDHKNPEFTTLINASHEFVESATSGNPVDFFP
ILRYIPNPQLQRFKEFNQRFLKFLQNTIREHHKAFDENNIQDITGALYKHSQDKAFGNTS
SSVPEMLIINLINDIFGAGFDTVTTAISWSLMYLVTNPKVQKKIQQELDTVIGRDRWPLL
SDRPQLPFMEAFILEIFRHTSFVPFTIPHSTTRATTLNNFYIPKGTCVFVNQWQTNHDPK
LWEDPSVFRPERFLSADGTVNKALSEKVILFGLGKRRCIGETIARWEVFLFLAILLHQIE
FSVPSGVKVDMTPTYGLTMKHPRCEHFQARPRFSR
CYP1A2 chicken
GenEMBL M64537 (884bp)
Swiss Q01741 (258 amino acids)
Murti,J.R., Adiga,P.R. and Padmanaban,G.
Estradiol-17-Beta induces polyaromatic hydrocarbon-inducible
cytochrome p-450 in chicken liver
Biochem. Biophys. Res. Commun. 175, 928-935 (1991)
Note: previously called 1A2
CYP1A2 Eumetopias jubatus (Steller sea lion)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
clone #2
submitted to nomenclature committee 5/15/98
CYP1A2 Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 6/28/99 revised 2/27/01
CYP1A1/CYP1A2 chimera Phoca fasciata (Ribbon seal)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 6/28/99
on 2/27/01 the authors sent the following message
"... we believe that the production of the chimera
sequence could be the result of a PCR defect."
CYP1A2 Halichoerus grypus (grey seal, gray seal)
No accession number
Rachel Tilley
Submitted to nomenclature committee 3/19/2001
Name grey seal 2
CYP1A2 Phoca groenlandica (harp seal)
No accession number
Rachel Tilley
Submitted to nomenclature committee 3/19/2001
Name harp seal 2
Cyp1a2 mouse
GenEMBL K02589 (1893bp)
Kimura,S., Gonzalez,F.J. and Nebert,D.W.
The murine Ah locus.
J. Biol. Chem. 259, 10705-10713 (1984)
Cyp1a2 mouse
PIR A93512 (513 amino acids)
Kimura, S., Gonzalez, F.J. and Nebert, D.W.
Mouse cytochrome P-3-450: complete cDNA and amino acid
sequence.
Nucleic Acids Res. 12, 2917-2928 (1984)
Cyp1a2 mouse
GenEMBL X01682 (6715bp)
Kimura,S., Gonzalez,F.J. and Nebert,D.W.
The murine Ah locus: Comparison of the complete cytochrome P1-450
and P3-450 cDNA nucleotide and amino acid sequences
J. Biol. Chem. 259, 10705-10713 (1984)
Cyp1a2 mouse
GenEMBL M25624 (510bp)
Peterson,T.C., Gonzalez,F.J. and Nebert,D.W.
Methylation differences in the murine P-1-450 and P-3-450 genes in
wild-type and mutant hepatoma cell culture
Biochem. Pharmacol. 35, 2107-2114 (1986)
Cyp1a2 mouse
PIR B92495 (513 amino acids)
Gonzalez, F.J., Kimura, S. and Nebert, D.W.
J. Biol. Chem. 260, 11884-11889 (1985)
Erratum
Cyp1a2 mouse
GenEMBL M10022 (8865bp)
PIR B24953 (30 amino acids)
Gonzalez,F.J., Mackenzie,P.I., Kimura,S. and Nebert,D.W.
Isolation and characterization of full-length mouse cDNA and
genomic clones of 3-methylcholanthrene-inducible cytochrome
P-1-450 and P-3-450
Gene 29, 281-292 (1984)
Cyp1a2 mouse
PIR A45955 (42 amino acids) PIR B45955 (39 amino acids)
Peterson, T.C., Gonzalez, F.J. and Nebert, D.W.
Methylation differences in the murine P-1-450 and P-3-450
genes in wild-type and mutant hepatoma cell culture.
Biochem. Pharmacol. 35, 2107-2114 (1986)
Cyp1a2 mouse
PIR D24406 (25 amino acids) PIR E24406 (25 amino acids)
Cheng, K.C., Park, S.S., Krutzsch, H.C., Grantham, P.H.,
Gelboin, H.V. and Friedman, F.K.
Amino-terminal sequence and structure of monoclonal antibody
immunopurified cytochromes P-450.
Biochemistry 25, 2397-2402 (1986)
CYP1A2 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
82% to CYP1A2 human, 69% to CYP1A1
CYP1A2 Pusa sibrica (Baikal seal)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
80% to CYP1A1 human, 69% to CYP1A2
Fish Cytochrome P450s are undergoing a revision to their nomenclature. Initially
there appeared to be just one fish 1A gene per species, but that is not true as shown
by Amy Berndtson in trout. Until an adequate nomenclature can be devised, these fish
sequences are listed as CYP1A, without a number following the subfamily. This does
not affect the mammalian gene designations, though it may affect the chicken
sequences.
CYP1A1 Oncorhynchus mykiss (trout)
GenEMBL S69278 (5023bp)
Berndtson,A.K. and Chen,T.T.
Two unique CYP1 genes are expressed in response to
3-methylcholanthrene treatment in rainbow trout.
Arch. Biochem. Biophys. 310, 187-195 (1994)
Note: published as CYP1A2, but it is more similar to Heilmann's sequence
than Berndtson's 1A1 (97.9% identical).
CYP1A1 Oncorhynchus mykiss (trout)
GenEMBL U62797(1697bp)
Bailey,G., You,L. and Harttig,U.
Cloning, sequencing and functional expression of two trout CYP1A
cDNAs in yeast
unpublished (1997)
incorrectly called 1A2
CYP1A3 Oncorhynchus mykiss (trout)
GenEMBL U62796(2401bp)
Bailey,G., You,L. and Harttig,U.
Cloning, sequencing and functional expression of two trout CYP1A
cDNAs in yeast
unpublished (1997)
incorrectly called 1A1
CYP1A Oncorhynchus mykiss (trout)
GenEMBL AF015660
Bailey,G., You,L. and Harttig,U.
Cloning,sequencing and aflatoxin B1 metabolism by multiple rainbow
trout CYP1A cDNAs expressed in yeast
Unpublished
8 amino acid differences with U62797
CYP1A3 Oncorhynchus mykiss (trout)
GenEMBL S69277 (5524bp)
Berndtson,A.K. and Chen,T.T.
Two unique CYP1 genes are expressed in response to
3-methylcholanthrene treatment in rainbow trout.
Arch. Biochem. Biophys. 310, 187-195 (1994)
Note: published as CYP1A1. This sequence is 96.7% identical to
Heilmann's 1A1 sequence.
CYP1A1/CYP1A3 chimera Oncorhynchus mykiss (trout)
PIR A28789 (522 amino acids)
Heilmann, L.J., Sheen, Y.Y., Bigelow, S.W. and Nebert, D.W.
Trout P450IA1: cDNA and deduced protein sequence, expression
in liver, and evolutionary significance.
DNA 7, 379-387 (1988)
Published as CYP1A1
note: subsequent analysis has shown that the 5' end of this sequence
comes from the 1A3 gene and the switch over occurs between base 271
and base 435 with base 1 as the A of the ATG start codon.
CYP1A Pleuronectes platessa (plaice, a fish)
GenEMBL X73631 (2411bp) PIR S34184 (521 amino acids)
Leaver,M.J., Pirrit,L. and George,S.G.
Cytochrome P450 1A1 cDNA from plaice (Pleuronectes platessa)
Mol. Marine Biol. Biotechnol. 2, 338-345 (1993)
CYP1A Opsanus tau ( oyster toadfish)
GenEMBL U14161 (2352bp)
Morrison, H.G., Oleksiak, M.F., Cornell, N.W., Sogin,M.L. and
Stegeman, J.J.
Identification of Cytochrome P450 1A genes from two teleost fish, toadfish
(Opsanus tau) and scup (Stenotomus chrysops), and pyhlogenetic analysis
of CYP1A genes.
Biochem. J. 308, 97-104 (1995)
CYP1A Stenotomus chrysops (scup, a fish)
GenEMBL U14162 (1566bp)
Morrison, H.G., Oleksiak, M.F., Cornell, N.W., Sogin,M.L. and
Stegeman, J.J.
Identification of Cytochrome P450 1A genes from two teleost fish, toadfish
(Opsanus tau) and scup (Stenotomus chrysops), and pyhlogenetic analysis
of CYP1A genes.
Biochem. J. 308, 97-104 (1995)
CYP1A Chaetodon capistratus (four-eye butterfly fish)
GenEMBL U19855 (2552bp)
Vrolijk,N.H., Lin,C. and Chen,T.T.
Characterization and expression of a CYP1A gene from the tropical
teleost, Chaetodon capistratus.
Unpublished 1995
CYP1A Dicentrarchus labrax (european sea bass)
GenEMBL U78316(1563bp)
Stien,X., Amichot,M., Berge,J.-B. and Lafaurie,M.
Molecular cloning of a CYP1A cDNA from the teleost fish
Dicentrarchus labrax.
Unpublished (1995)
CYP1A1v2 Dicentrarchus labrax (european sea bass)
No accession number
Alessandra Salvetti
Submitted to nomenclature committee 11/26/99
94% identical to U78316 probably an allele
CYP1A Microgadus tomcod (Atlantic tomcod)
GenEMBL L41886 (2497bp) L41917
Roy,N.K., Konkle,B.A., Kreamer,G.-L., Grunwald,C. and Wirgin,I.I.
Characterization and prevalence of a polymorphism in the 3'
untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod
Arch. Biochem. Biophys. (1995) In press
probable frameshift detected by O. Gotoh. in the beginning of the sequence.
CYP1A Microgadus tomcod (Atlantic tomcod)
GenEMBL L41917 (6837bp)
Roy,N.K., Konkle,B. and Wirgin,I.I.
Functional characterization of Cytochrome P4501A1 regulatory
sequences in cancer-prone Atlantic tomcod.
Unpublished (1995)
CYP1A Pagrus major (wild red sea bream)
no accession number
Mizukami,M., Okauchi,M., Ariyoshi,T. and Kito,H.
The isolation and sequence of cDNA encoding a 3-methylcholanthrene-
inducible cytochrome P450 from wild red sea bream, Pagrus major.
Marine Biol. 120, 343-349 (1994)
CYP1A Sparus aurata (gilthead sea bream)
GenEMBL AF011223, AF005719
CYP1A Liza aurata
GenEMBL AF022433
Cousinou,M., Lopez-Barea,J. and Dorado,G.
CYP1A Liza saliens (leaping mullet)
GenEMBL AF072899
Alaattin Sen and Don Buhler
submitted to nomenclature committee
96% identical to Liza aurata
CYP1A Limanda limanda
GenEMBL AJ001724
Robertson,F.E., McPhail,M.E., Rankin,R., Stagg,R.M. and Craft,J.A.
CYP1A Platichthys flesus (European flounder)
GenEMBL AJ132353
Williams,T.D., Lee,J.S. and Chipman,J.K.
The cytochrome P450 1A gene (CYP1A) from European flounder
(Platichthys flesus), analysis of regulatory regions and
development of a dual luciferase reporter gene assay.
Unpublished
CYP1A1 Salmo salar (salmon)
No accession number
Christopher Rees Weiming Li
submitted to nomenclature committee Nov. 9, 2001
a second gene is being isolated so this is called 1A1
rather than just CYP1A. This does not imply orthology to the
mammalian 1A1, 1A2. The CYP1A gene duplications in fish and mammals
occurred independently.
CYP1A Anguilla anguilla (European eel)
GenEMBL AF420257
Mahata,S.C., Mitsuo,R., Aoki,J.-y., Kato,H. and Itakura,T.
Two forms of cytochrome P450 cDNA from 3-methylcholanthrene-treated
European eel Anguilla anguilla
Fish. Sci. 69 (3), 615-624 (2003)
98% identical to CYP1A9 from Japanese eel (clear ortholog)
note: Eels have two CYP1A sequences. This one is 80% identical to
Salmo salar CYP1A. CYP1A9 is 77% to the same Salmo CYP1A
Therefore, CYP1A9 is a recent duplication in eels that is diverging
Away from the parent sequence called CYP1A (no number after A).
Called CYPEuMC1
CYP1A Anguilla japonica (Japanese eel)
GenEMBL AB015638
Mitsuo,R., Itakura,T. and Sato,M.
Cloning and Sequencing of Cytochrome P450 1A Complementary DNA in
Eel (Anguilla japonica)
Mar. Biotechnol. 1 (4), 353-358 (1999)
98% identical to CYP1A9 from European eel (clear ortholog)
note: Eels have two CYP1A sequences. This one is 81% identical to
Salmo salar CYP1A. CYP1A9 is 78% to the same Salmo CYP1A
Therefore, CYP1A9 is a recent duplication in eels that is diverging
Away from the parent sequence called CYP1A (no number after A).
Called CYPJaMC1
CYP1A Danio rerio (zebrafish)
GenEMBL AY398333.1, AB078927.1
Gene is on CAAK02015935.1 (exon 1), CAAK02015934 (exons 2-6)
MALTILPILGPISVSESLVAIITICLVYLLMRLNRTKIPDGLQK
LPGPKPLPIIGNVLEIGNNPHLSLTAMSKCYGPVFQIQIGMRPVVVLSGNDVIRQALL
KQGEEFSGRPELYSTKFISDGKSLAFSTDQVGVWRARRKLALNALRTFSTVQGKSPKY
SCALEEHISNEGLYLVQRLHSVMKADGSFDPFRHIVVSVANVICGICFGRRHSHDDDE
LVRLVNMSDEFGKIVGSGNPADFIPFLRILPSTTMKKFLDINERFSKFMKRLVMEHYDTFDK (0)
DNIRDITDSLINHCEDRKLDENSNLQVSDEKIVGIVNDLFGA (1)
GFDTISTALSWAVVYLVHYPEVQERLQREL (1)
DEKIGKDRTPLLSDRANLPLLESFILEIFRHSSFLPFTIPHC (2)
TSKDTSLNGYFIPKDTCVFVNQWQVNHDP (2)
ELWKDPSSFIPDRFLTADGTELNKLEGEKVLVFGLGKRRCIGESIGRAEVFLFLAILL
QRLKFTGMPGEMLDMTPEYGLTMKHKRCLLRVTPQPVF
CYP1A Gobiocypris rarus (a rare minnow)
GenEMBL EU106660
Jiayin Dai
Submitted to nomenclature committee 4/19/2008
87% to CYP1A Danio
CYP1A Callorhinchus milii (elephant shark, Chondrichthyes)
Trace file 1573735839 78% to 1A zebrafish
1576735840 these two trace files are mate pairs
IRDITDSLIEHCQDKKMDENANIQVSDEKIINIVNDLFGA (1)
GFDTITTGLSWAVMYLVLYPDLQKRLQDEI (1)
DEKIGKDRSPRLSDRSRLPYTDAFILETFRYSSFLPFTIPHC (2)
TTKDTALNGYFIPKNTCVFVNQWQVNHDE (2)
CYP1A Petromyzon marinus (sea lamprey)
Trace files
1255373015 (DAVV exon +)
1386924597 (DAVV exon +)
1210995499 (DAVV exon +)
1437249679 (TTRD exon +)
1468852008 (TTRD exon +)
1442353648 (TTRD exon +)
1439550570 (ALWDE exon -) mate = 1442736929 = (TTRD exon +)
56% to 1A1 and 1A2 human, 61% to Bos 1A2
N-term part seems to be in a seq gap
DAVVGRQRRPSLNDRRQLPFTEAFILEVLRHSSVVPFTIPHS (2)
TTRDTVLQGFFIPKDTCIFINQWQVNHDS (2)
ALWDEPFAFRPERFLSEDQSSVDRTRAANLLSFGTGKRRCMGEAVARSELFLFLSILLHHL
RIRTADGQAPDMSAVYGLSLKHRTCLLLAESRS*
CYP1A4 Gallus gallus (chicken)
GenEMBL X99453(2098bp)
Gilday,D.J., Gannon,M., Yutzey,K., Bader,D. and Rifkind,A.
Molecular cloning and expression of two novel avian cytochrome P450
1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J. Biol. Chem. 271, 33054-33059 (1996)
CYP1A4 Phalacrocorax carbo (Commmon Cormorant)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
78% to CYP1A4 chicken, 72% to CYP1A5 chicken, 59% to CYP1A zebrafish
CYP1A5 Gallus gallus (chicken)
GenEMBL X99454(1845bp)
Gilday,D.J., Gannon,M., Yutzey,K., Bader,D. and Rifkind,A.
Molecular cloning and expression of two novel avian cytochrome P450
1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J. Biol. Chem. 271, 33054-33059 (1996)
CYP1A5 Meleagris gallopavo (turkey)
No accession number
Roger Coulombe, Jr.
Submitted to nomenclature committee May 5, 2004
95% to chicken 1A5
CYP1A5 Phalacrocorax carbo (Commmon Cormorant)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
78% to CYP1A5 chicken, 69% to CYP1A4 chicken, 58% to CYP1A zebrafish
CYP1A5 Corvus macrorhynchos (Jungle crow)
No accession number
Hisato Iwata
submitted to nomenclature committee 4/15/05
75% to 1A5 chicken 67% to 1A4 chicken
CYP1A6 Xenopus laevis (African clawed frog)
GenEMBL AB022087
Fujita,Y. and Ohi,H.
Xenopus laevis mRNA for cytochrome P450, cDNA clone MC1
unpublished(1999) In press
clone MC1
CYP1A7 Xenopus laevis (African clawed frog)
GenEMBL AB022088
Fujita,Y. and Ohi,H.
Xenopus laevis mRNA for cytochrome P450, cDNA clone MC2
unpublished(1999) In press
clone MC2
CYP1A8PX human
NT_008580.9
Pseudogene 43% identcal to 1A2 human
Renamed CYP1D1P orthologous to fish 1D1
NT_008580.9|Hs9_8737 chromosome 9
4822084 MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPY 4822260
4822261 LTLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKS 4822440
4822441 LSFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSK 4822620
4822621 NGSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCL 4822800
4822801 HYLPLKIINAPLEFYQALNGFIALHVQDHLATYGK 4822905 (0)
4824790 DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVSDLFGA 4824912 (1)
4829424 GFETVSTCLCWSFLYLIHYPEIQARIQEEI 4829513 (1)
4829611 RPPRFEDRKILPYTEAFVSEVFRHASFLPFTIPHS 4829715 (2)
4832677 TTADTTLNGYFIPRKTCTFINMYQVNHDE 4832763 (2)
4835676 TIWDNHSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFK 4835858
4835859 LKK*PRAKLDLTPTYGLVMRPKLYQLQAELHPSGSSSA* 4835975
CYP1A8PX ortholog Bos taurus (cow)
Renamed CYP1D1P orthologous to fish 1D1
See cattle page for details
MIFGMAVTSGEVTTSRIILVMVFVFVRELGNKGRKEVFPPGPWSLPIVENLLQLG
DHLYFTFMEMRKKYGDVFLIKLGMVPVLVVNGMEMVKEVLLRNGEHFAA*PNV
LTFSFLAQ*KSLTFS
NYGENWTLHKKIASNALRTFPKAETKSSTRSCLLEKHVIEEVSELVKV
FTELTSRSGSFEPRGAITCAMANVV
CTLCFGKRYDHSDEEFLRIVKTDHDLLKASSAANPADFIPYF*YLPLRIINAPQEFYHARNQ
FIALHIRDHLTT
CPQDHIQDITDALINACHNKYAVAKITILNDDEIISTVSDLVGAG
FEIISTCIYWSFLYLIYYPEIQVKIQEEI
DGNTGMKSPRFENRKILP
YTEAFINEIFRHTSFLPFTIPHC (2)
TTADTTLNGYFIPRKTCTFINMYQVNHDE (2)
TIWDNPNLLRPERFLNENRELNKNLIEKIFIFGMGIQKCL
REEVAQNEVFVFITTVLQQLTLKKCPVVKLDLTPTYGLVMKPKPYQLPAEPRSMGSSCS*
CYP1A8PX ortholog Xenopus tropicalis (frog)
This is not a pseudogene in frogs
It needs a new subfamily name, since it is
Separate from the CYP1A subfamily
See Xenopus page for seq
Renamed CYP1D1
CYP1A9 Anguilla anguilla (European eel)
GenEMBL AF420258
Mahata,S.C., Mitsuo,R., Aoki,J.-y., Kato,H. and Itakura,T.
Two forms of cytochrome P450 cDNA from 3-methylcholanthrene-treated
European eel Anguilla anguilla
Fish. Sci. 69 (3), 615-624 (2003)
98% identical to CYP1A9 from Japanese eel (clear ortholog)
note: Eels have two CYP1A sequences. CYP1A is 80% identical to
Salmo salar CYP1A. This seq is 77% to the same Salmo CYP1A
Therefore, this is a recent duplication in eels that is diverging
Away from the parent sequence called CYP1A (no number after A).
Called CYPEuMC2
CYP1A9 Anguilla japonica (Japanese eel)
GenEMBL AB020414
Mitsuo,R., Itakura,T. and Sato,M.
Cloning and Sequencing of Cytochrome P450 1A Complementary DNA in
Eel (Anguilla japonica)
Mar. Biotechnol. 1 (4), 353-358 (1999)
98% identical to CYP1A9 from European eel (clear ortholog)
note: Eels have two CYP1A sequences. CYP1A is 81% identical to
Salmo salar CYP1A. This seq is 78% to the same Salmo CYP1A
Therefore, this is a recent duplication in eels that is diverging
Away from the parent sequence called CYP1A (no number after A).
Called CYPJaMC2
1B Subfamily
CYP1B1 human
GenEMBL U03688 (5102bp)
Sutter,T.R., Tang,Y.M., Hayes,C.L., Wo,Y.-Y.P., Jabs,E.W.,
Li,X., Yin,H., Cody,C.W. and Greenlee,W.F.
Complete cDNA sequence of a human dioxin-inducible mRNA
identifies a new gene subfamily of cytochrome P450 that maps to
chromosome 2.
J. Biol. Chem. 269, 13092-13099 (1994)
*** Note The CYP1B1 gene has been linked to primary congenital glaucoma****
See April 97 Human Molecular Genetics
CYP1B1 human
GenEMBL U56438 (12177bp)
Tang,Y.M., Wo,Y.-Y.P., Stewart,J., Hawkins,A.L., Griffin,C.A.,
Sutter,T.R. and Greenlee,W.F.
Isolation and characterization of the human cytochrome P450 CYP1B1
gene.
J. Biol. Chem. 271, 28324-28330 (1996)
CYP1B1 Bos taurus (cow)
See cattle page for details
MATGLSPDDHLSPTLLSVQQTMLLLLLSVLAAVHVGQWLLRQRRRQPGSAPPGPFAWPLI
GNAASMGSAPHLLFARLARRYGDVFQIHLGSCRVVVLNGERAIRQALVHQSAAFADRPPF
ASFRLVSGGRSLAFGQYSESWKAQRRAAHSTMRAFSTRQPRGRRVLEGHVVGEVRELVEL
LVRRSAGGAFLDPRPLTLVAVANVMSALCFGCRYSHDDAEFLELLSHNEEFGRTVGAGSL
VDVLPWLQRFPNPVRTAFREFEQLNRNFSNFVLDKFLRHRESLRPGAAPRDMMDAFIHSA
GADSGDGGPRLDVDYVPATVTDIFGASQDTLSTALQWLLVLFTR (2)
YSEVQARVQAELDQVVGRHRLPTLEDQPRLPYVMAFLYEAMRFSSFVPVTIPHATTANAS
VLGYHIPKDTVVFVNQWSVNHDPVKWSNPEDFDPTRFLDKDGLINKDLTGSVMVFSVGKR
RCIGEEISKMQLFLFISILAHQCNFKANPDEPSKMDFNYGLTIKPKSFKINVTLRESMEL
LDSAVQKLQVEKECQ*
CYP1B1 rat
GenEMBL X83867 (2321bp)
Battacharyya,K.K., Brake,P.B., Eltom,S.E., Otto,S.A. and Jefcoate,C.R.
Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon
metabolism as a rat CYP1B1. Demonstration of a unique tissue-specific pattern of
hormonal and aryl; hydrocarbon receptor-linked regulation.
J. Biol. Chem. 270 11595-11602 (1995)
CYP1B1 rat
GenEMBL U09540(4964bp)
Nigel Walker
Walker,N.J., Gastel,J.A., Costa,L.T., Clark,G.C., Lucier,G.W. and
Sutter,T.R.
Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent
expression in livers and kidneys of TCDD-treated animals.
Carcinogenesis 16 (6), 1319-1327 (1995)
Cyp1b1 mouse
GenEMBL U02479 (317bp)
Shen,Z., Wells,R., Liu,J. and Elkind,M.M.
Identification of a cytochrome P450 gene by reverse transcription-
PCR using degenerate primers containing inosine.
Proc. Natl. Acad. Sci. USA 90, 11483-11487 (1993)
Note: only 104 amino acids by PCR.
Cyp1b1 mouse
GenEMBL U03283 (5128bp)
Shen,Z., Liu,J., Wells,R.L. and Elkind,M.M.
cDNA cloning, sequence analysis, and induction by aryl hydrocarbons
of a murine cytochrome P450 gene, Cyp1b1.
DNA Cell Biol. 13, 763-769 (1994)
Cyp1b1 mouse
GenEMBL X78445 (2006bp)
Savas,U., Bhattacharyya,K.K., Christou,M., Alexander,D.L. and
Jefcoat,C.R.
Mouse cytochrome P450EF, representative of a new 1B subfamily of
cytochrome P450s. Cloning, sequence determination, and tissue
expression.
J. Biol. Chem. 269, 14905-14911 (1994)
CYP1B1 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP1B1X Fundulus heteroclitus (killifish)
GenEMBL AF235140
Celine Godard, Maya Said and John Stegeman
Submitted to nomenclature committee Feb. 16, 2000
This seq is a CYP1C2 sequence not CYP1B1
CYP1B1 Platichthys flesus (European flounder)
GenEMBL AY304550
68% to 1B1 fugu
IKTIFXNFKKLNLEFGEFIRDKVIEHRKTIQSSTTRDMTDALIM
ALDKLGDKTELTGGKDYVSPTMGDIFGASQDTLSTALQWIVLILVKYPEMQLRVQQEV
DKVVERTRLPSIEDQLQL
CYP1B1 Danio rerio (zebrafish)
no accession number
66% to 1B1 fugu ctg26141 Length = 651601
4 exons
EST BQ419016
494367 MMDVLLALRDLLQLSTRSVLLSLMVCLMLMFRRRQLVPGPFSWPVIGNAAQLGNTP 494534
494535 HFYLSRMAQKYGDVFQIKLGSRNVVVLNGDAIKEALVKKATDFAGRPDFASFRFVSNGKS 494714
494715 MAFGNYTPWWKLHRKVAQSTVRNFSTANIQTKQTFEKHIVSEIGELIRLFLNKSREQQFF 494894
494895 QPHRYLVVSVANTMSAVCFGNRYAYDDAEFQQVVGRNDQFTKTVGAGSMVDVMPWMQYFP 495074
495075 NPIRTLFDQFKELNKEFCAFIELKVSEHRKTISPSHVRDMTDAFIVALDKGLSGGSGVSL 495254
495255 DKEFVPPTISDIF 495293
495379 GASQDTLSTALQWIILLLVR 495438
497442 YPEIQKRLQEDVDRVVDRSRLPTIADQPHLPYLMAFIYEVMRFTSFTPLTIPHS 497603
497604 TTKDTSINGYPIPKDTVIFVNQWSLNHDPTKWDQPEVFNPQRFLDEDGSLNKDLTTNVLI 497783
497784 FSLGKRRCIGEDVSKIQLFLFTSVLVHQCSFKAESTPNMDYEYGLTLKPKPFKVSVTARD 497963
497964 SSDLLDSLVGTSQTPTEKR 498020
CYP1B1 Danio rerio (zebrafish)
GenEMBL AF235139
Celine Godard, Maya Said and John Stegeman
Submitted to nomenclature committee Feb. 16, 2000
SQDTLSTALQWIILLLVRYPEIQKRLQEDVDRVVDRSRLPTIAD
QPHLPYLMAFIYEAMRFTSFTPLTIPHSTTKDTSINGYPIPKDTVIFVNQWSLNHDPT
KWDQPEVF
CYP1B1P Danio rerio (zebrafish)
No accession number (from trace index)
gnl|ti|30343474 zfishB-a1803b07.p1c Length = 630
probable 1B1 pseudogene zebrafish
IADQPHLPYMMAFIYEVMRFTSFTP
TTNVLIFSLGKRRCIGEDVSKIQLFLFTSVMVHQ*RIKAESTPNMGYVXXXXX
LKPKPFKVSVTARDSSDQLISLAGTSQTPTEK
CYP1B1 Cyprinus carpio (common carp)
GenEMBL AB048942
73% to 1B1 fugu
LSTALQWIILLLVRYPEVQKRLQEDVDKVADRSRLPTIADQPHL
PYVMAFIYEVMRFTSFVPVTIPYSTTTDTSINGYPIPKDTVIFV
CYP1B1 Cyprinus carpio (common carp)
No accession number
Itakura, T. and El-kady M.A.H.
Submitted to nomenclature committee 10/17/2003
Full length sequence 1 aa diff to fragment on AB048942
91% to CYP1B2 carp 64% to 1B1 fugu 53% to 1C1 fugu
clone name carp1B1a
CYP1B1 Stenella coeruleoalba (striped dolphin)
no accession number
Celine Godard, Maya Said and John Stegeman
submitted to nomenclature committee Nov. 20, 1998
PCR fragment 90% identical to human 1B1 I-helix to PERF motif region
CYP1B1 Pusa sibirica (Baikal seal)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
84% to 1B1 human
CYP1B1 Pleuronectes platessa (plaice)
GenEMBL AJ249074
Michael Leaver
submitted to Nomenclature Committee 3/11/99
full length seq.
MFLQDPPAMDVTLEGIDPVTLRAVLLACVTLLFSLHLWRWLGGQ
PSVPGPPGPLAWPLIGNAAEMGKLPHLYLTRMAHKYGNVFQIKLGSRTVVVLNGDSIK
QALVKQGTDFAGRPDFASFKYIFDGDSLAFGPFTDWWKVHRRVAQSTVRTFSTGNADT
KKTFEHHVLCEFRELLQLFVGKTEQQRFFQPMTYLVVSTANIMSAVCFGKRYAYEDEE
FLQVVGRNDQFTQTVGAGSIVDVMPWLQYFPNPIRTIFDNFKKLNLEFGQFIRDKVIE
HRKTIQSSTTRDMTDALIVALDKLGDKSELTGGKDYVSPTMGDIFGASQDTLSTALQW
IVLILVKYPEMQLRIQQEVDKVVDRTRLPSIEDQLQLPYIMAFVYEVMRFTSFVPLTI
PHSTVTDTSIMGYTIPKNTVIFINQWSINHDPALWSHPETFDPQRFLDQNGALNKDLT
SSVLIFSLGKRRCIGEELSKMQLFLFTALIAHQCHISPDPARPPKLDYTYGLTLKPCA
FSIAVALRGHDMSLLDEATRSSAEEVKGEPSSDSQTKN
CYP1B1 Fugu rubripes (Takifugu rubripes) Japanese pufferfish
Scaffold_1553 complete gene Scaffold_11030 Scaffold_10662
54% TO 1B1 human 51% to 1B1 mouse
AL024920.1 AL015454.1 cosmid 077P23
80% to CYP1B from pleuronectes platessa
FC:C013F14aE4 LGU7740.y1 FC:C077P23aC12
AL015446.1 077P23 FC:C077P23aD8
2460 MKVIQEEVSPEAGALLLACATLLVSLQLWRWRRRRPGGCPPGPRAWPIIGNAAQLGHAPHL 2278
2277 YFTRMAQRFGNVFQIKLGSRTVVVLNGDAIKQALVRKGLEFAGRPDFTSFKYISNGHSL 2101
2100 AFGTVTDWWKSHRRVAQSTVRMFSTGNLQTKKTFERHLTCEVRELLHLFLGKTKELQYFQ 1921
1920 PMNYLVVSTANVISAVCFGKRYSYEDEEFQQVVGRNDQFTRTVGAGSIVDVMPWL 1756
1755 QYFPNPVKSIFDNFKRLNKEFSDFIRDKVTEHRKSIRPSSVRDMTDAFIVSLDKLSE 1585
1584 KTGVPLWKDYVIPTVGDVFGASQDTLSTALQWIFLVLVR 1468 (2)
294 YPDMQQRLQEEVDLVVGRQRLPCIEDQQQLPWVMAFIYEVMRFTSFVPLTIPHSTTTDTT 115
114 IMGYTIPKNTIIFINQWSINHDPTIWSHPET 13
FDPNRFLNPSGSLNKDLTSRMLIFSMGKRRCIGEELSKLHLFLFTALIGHQCHITDDPA
KPTTMDYNYGLTLKPRGFYVALTLRGDMRLLDEAASRPPAEEPGRGPLADP*
CYP1B1 Tetraodon nigroviridis (freshwater pufferfish)
No accession number
80% to CYP1B1 fugu missing first 50 aa and last 18 aa
FS_CONTIG_703_2 Length = 26665
69 NAAQLGKAPHLYFASRAERYGNVFQIRLGARSVVVLNGDAIRQALVKQGPEFAGRPDFAS 248
249 FGFISDGRSMAFGTATDWWKVHRRVAHSTVRMFSSGNAQTKKAFERHITSEVRELLRLFLRST 437
439 RAQRFFQPLAPLVVSTANVMSAVCFGKRYSYEDEEFQQVVGRNDQFTRTVGAGSVVDVMP 618
619 WLQYFPNPVKTIFDDFKRLNREFNSFIRDKVSEQ 720
722 RKTIQSSSVRDMTDALIASLDRLSAKTGVP 811
812 LWKEYVTPTVGDVFGASQDTLSTALQWIFLVLV 910
1486 RYPDVQQRLQKEVDQVVGRQRLPCLEDQQQLPWVMAFIYEVMRFTSFMPLTIPHSTTTDT 1665
1666 TIGGYSIPRNTVVFINQWSVNHDPAIWPQPETFDPDRFLNPNGSLNKDLTSSVLIFSLGK 1845
1846 RRCIGEELAKLHLFLFTALMGHQCRLASDPARPPSLDWNYGLTLKPHAFHIAVSLRGDMRLLDQ 2037
CYP1B1 Anguilla japonica (Japanese eel)
GenEMBL AB048940
73% to 1B1 fugu
LSTALQWIILVLVRFPDIQKQLREEVDKVVDSSRLPSIEDQPRL
PYVMAFLYEVMRFTSFIPVTIPHSTTTDTAIQGYRIPKDTVVFI
CYP1B1 Oreochromis niloticus (Nile tilapia)
GenEMBL AB048944
80% to 1B1 fugu
LSTALQWIILILVKYPEIQVRLQQEVDKVVDRSRVPAIEDQQQL
PYVMAFIYEVMRFTSFLPLTIPHSTTTDTSIMGYTVPKNTVIFI
CYP1B1 Callorhinchus milii (elephant shark, Chondrichthyes)
Trace files 1573810313 1573059473
57% to 1B1 zebrafish only 49% to 1C
MNAVRVLAGQFTQSMQPVLAVALVVLTLLQVCKWMQQPSEQCRRRPPGPFPWPII
GNATQIGKVPHISFSRMARRYGNVFQIKLGSRSVVVLNGEECIREALVRKAEQFSGRPDF
ASFNEVSGGRSLAFRSYCDRWKFHRRIAHSTVRAFSTNNPDTKKTFQRHVVGEVQQLSSR
RQ
CYP1B1 Petromyzon marinus (sea lamprey)
Trace files 1172235440, 1468167059, 1466822831, 1172788718,
1373603965, 1464676455
54% to 1B1 zebrafish, 48% to 1C2, 53% to CYP1B3 Petromyzon marinus
SSNVVEFALLVALEARRWLLLRRARSSRGPPGPFPWPILGNALQLGSAPHLAMCRMARRY
GDVFMMKLGGRPVLVLNGATAIRQALVKQGAD
FAGRPAFPSFSVVSDGNSMAFGGYSSLWKMHRCVAQST
LRHFSSSGNAEARADLERYV
VSEAGALVGIMLERSDGGRYFNPSRLFILAIANVMSALCFGRRYDYDNSEFREIV
SRNDKFGRTVGAGSLVDVMPWLLYFPNPVRTAYRDFVALNMEFNAFTRRKVEQHRADFKA
GGVPRDITDSLIAAVEVERPRSRSGEALSGRHVSGAVNDIFGASQDTLSTALMWLLMFLV
RFPRAQRRVQEEVD RVAGRHRLPCLEDRASLPYTEAFVFETLRYSSFVPV
TIPHSTTTDTVIAGYCVPKDTVVFVNQWSSNHDPERWRDPETFEPTRFL
DESGTRVDKDLASNVLIFSVGKRRCIGDDISKMQLLLFAAILAHQCSFEADPAQTMT
IDKSYGLTLKPMPFEVRARVRDHVLAECFADARRQL*
CYP1B3v1 Petromyzon marinus (sea lamprey)
Trace 1373790297 first exon 49% to 1B1 fugu, 50% to 1C1 zebrafish
1437356431 mate pair = 1438643165 = C=term of 1223244203 seq
1290968067 52% to Stenotomus chrysops P450 1C1
combined frags 49% to 1B1 zebrafish
45% to 1C2 zebrafish, 39% to 1A1 zebrafsih
1223244203, 1473037756, 1427240599, 1446950979 51% to 1B1
1438643165 = extreme C-term = mate pair of 1437356431
whole seq 51% to 1B1 human, 50% to 1B1 fugu, 49% to 1B1 zebrafish
MQSTLAILAVNPSRTPTSTASFTSTSTQLSIPSSHLPPPPPPPSIQPSSPAC
TLSQLPAHSPSAAASSPAVAAAPLHSLRTLPGPTPWPFVGNSLQLGPMPHLTFQRMASTY
GPLFRIRLGSRDVVVLNGDSLVREALVCRGSEFAGRPAFRSFSMVSGGHSV
AFGGYCELWRLHRRLAQSTLRAFSTGGTDARR ALDGHVMMEADELLRVMMA
SCRRSTAGSVDPAQALVVAVANVRSALCFRRRYWHED
AESSSSDRNERSGAAVGAGSVVDVMPW
LLRFPNPVRAAFDDIRRANEDLSEFVRDKVRQRRGAAAVVGPGTRSVRDMM
DALIAHVDGGAVAGGGAAEAAAGDGEGGEAAGGGRGGGGPRLGASHVEATLCDVFGASQD
TLSTGLLWLILLAVRHPEEQARVQGEVDRVVGRTRLPSAADRARMPRTEAFVCEVLRYSS
FVPVTIPHATTRDTRLAGYSIPRDTVVFVNQWSVNHDPGVFEEPHAFRPARF
LDAEGTALDRALARRVMIFSAGRRRCIGEELSRLELFLFTAVMLHQV
DFVAPPGHGPPGTEAVCGGLTLKPKPFSVALVPRGDPLGPGCAPQP*
CYP1B3v2 Petromyzon marinus (sea lamprey)
Trace files 1468808835, 1424613767 , 1489836465
allele of 1223244203? 4 aa diffs and one indel of 1aa
PVRAAFDDFRRANEDL
SEFVRDKVRQRRGAAAVVGPGTRSVRDMMDALISHVDGGAVAGGAAEAAAGDGEGGEAAGGERGGGGP
RLGASHVEATLCDVFGASQDTLSTGLLWLILLAVRHPEEQARVQGEVDRVVGRTRLPSAA
DRARMPRTEAFVCEVLRYSSFVPVTIPHATTRDTRLAGYSIPRDTVVFVNQWSVNHDPGV
FEEPHAFRPARFLDAEGTALDRALARRVMIFSAARFRCIGEELSRLELFL
CYP1B2X Stenotomus chrysops (scup, a fish)
no accession number
Celine Godard, Maya Said, and John Stegeman.
submitted to nomenclature committee full length 4/21/99
81% identical to scup 1B3
renamed CYP1C1
CYP1B3X Stenotomus chrysops (scup, a fish)
no accession number
Celine Godard, Maya Said, and John Stegeman.
submitted to nomenclature committee Aug. 26, 1998 full length 4/21/99
63% identical to human 1B1 over C-terminal PCR fragment
I-helix to heme
formerly 1B1, reaassigned to CYP1C2
Note: the CYP1B2 and 1B3 names from scup were never published.
It now appears that some fish like carp do have two CYP1B sequences, so the
CYP1B2 name is going to be used to indicate this fact. 10/20/2003
CYP1B2 Cyprinus carpio (common carp)
No accession number
Itakura, T. and El-kady M.A.H.
Submitted to nomenclature committee 10/17/2003
Full length sequence 3 aa diffs to fragment on AB048942
91% to CYP1B2 carp 64% to 1B1 fugu 53% to 1C1 fugu
clone name carp1B1b
CYP1C1 Gallus gallus (chicken)
XM_001233594.1
55% to CYP1C2 Fugu, 54% to 1C1 zebrafish
MSAMGTPNGAAMAPVLSPHSALLLIAVVLTAI
LLLARTRHKATRGQSPPGPFASPLVGNVLQMGRLPHLTFMRMACRYGAIFQLRLGRHRVV
VLNGEAAIRRALVGLGTRFAGRPDFPSFGLVSGGRSIAFGGCTPQWRARRRLAHAALRAH
STVAEVERHVVAEAGDLVRLFLRHSQGGAYFQPCPLLVVANANVLCALCFGRRYDHADGE
FTALLGRNDRFGQTVGAGSLVDVLPWLLRFPNPVRHVYRDFQALNRELHGFVQAKVAQHR
QTFDWRAVRDISDVMIASVERGGGSPDGLGPEDVEGAMTDIFGAGQDTTSTALSWIILLL
LKHPQVQQDLQAELDRVVGRSRLPTAEDRPHLPLLEAFIYETLRYSSFVPITIPHATTAD
VELEGFRIPKGTVVFVNQWSVNHDCSKWPEPQRFDPTRFLDKQQRLDRERAGSVMIFSAG
QRRCIGDQLSKLQIFLFTAILLHQCSFHANPAEHLTMDCIHGLALKPLPFTVNVRPRIPL
LIQP*
CYP1C1 Stenotomus chrysops (scup, a fish)
no accession number
Celine Godard, Maya Said, and John Stegeman.
submitted to nomenclature committee full length 4/21/99
81% identical to scup 1C2
formerly 1B2, reaassigned after consultation with the submitters
and comparison to the Fugu genomic orthologs (see below)
CYP1C1 Danio rerio (zebrafish)
GenEMBL CAAK02055884.1 6714 bp gene seq (revised seq shown below)
contig NA9599 Length = 11279
78% to 1C1 73% to 1C2 fugu 53% to 1B1
Note: CYP1C probably arose by a retrotransposition of a 1B1 cDNA
Since 1C has no introns and it is more similar to 1B1 than 1A
MEAEFGLKSSSIMREWSGQVQPALIASFI
3411 ILFFLEACLWVRNLTFKKRLPGPFAWPLVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGC 3232
3231 SDIVVLNGDAAIRKALVQHSTEFAGRPNFVSFQMISGGRSLTFTNYSKQWKTHRKVAQST 3052
3051 LRAFSMANSQTRKTFEQHVVGEAMDLVQKFLRLSADGRHFNPAHEATVAAANVICALCF 2872
2871 GKRYGHDDPEFRTLLGRVNKFGETVGAGSLVDVMPWLQS 2755
2753 FPNPVRSVYQNFKTINKGVFNYVKDKVLQHRDTYDRDVTRDMSDAIIGVIEHGKEST 2583
2582 LTKDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIE 2406
2405 DRCNLAYLDAFIYETMRFTSFVP 2337
2337 VTIPHSTTSDVTIEGLHIPKDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGALN 2167
2166 KDLTSSVMIFSTGKRRCIGEQIAKVEVFLFSAILLHQCKFERDPSQDLSMDCSYGLALKP 1987
1986 LHYTISAKLRGKLFGLVSPA* 1924
CYP1C1 Fugu rubripes
No accession number
Scaffold_3008b comp(8676-10253) no introns complete gene
86% to scup 1C1 75% to scup 1C2
10253 MALDTEFGVKSSSITREWSGQVQPALVASFLFLFCLEACLWVRNLRHKRRL
10100 PGPFAWPVVGNAMQLGQMPHITFAKLAKKYGNVYQIRLGCSNI 9972
9971 VVLNGDQAIHQALIEHSTEFAGRPNFVSFQMISGGRSLTFTNYSKQWKVHRKLAQSSLRA 9792
9791 FSSANKQTKIAFEQHVTAEANELVQAFLRYSTDGRYFDPAHEFTVAAANVMCALCFGKRY 9612
9611 GHDDHEFRCLLKKLNKFGETVGAGSLVDVMPWLQSFPNPVRSLYENFKSLNEEFFNFV 9438
9437 KNKVQEHRESFDPNVTRDMSDAMINVIEERKDGTLSKEFAEATITDLIGAGQDTVS 9270
9269 TVLQWIVLLLVKHPDKQAKLHELMDKVVGQDRLPTTEDRSSLAYLDAFIYETMRFTSFVP 9090
9089 VTIPHSTTSDVTIEGLRIPKDTVVFINQWSVNHDPLKWKDPHVFDPSRFLNENGDLNKDL 8910
8909 TSGVMIFSSGKRRCIGSQIAKVEVFLFAAILLHQCSFESDPSDPLTLDCSYGLTLKP 8739
LRCFVSAKPRGKLLGLVSPA* 8676
CYP1C1 Tetraodon nigroviridis (freshwater pufferfish)
No accession number
FS_CONTIG_2073_3 Length = 9880
87% to 1C1 70% to 1C2
5630 MALDTEFSVKSSGITREWSGQIQPALVASFLFLFCLEACLWVRNLRQKRRLPGPFAWPV 5806
5807 VGNAMQLGQMPHITFAKLAKKYGNVYQIRLGCSNIVVLNGDQAIXX 5938
5943 QALIQHSTEFAGRPNFVSFQMISGGRSLTFTSYSKQWKAHRKVAQSSLRAFSSANNQTKK 6122
6123 AFEQHVTAEANKLVQTFLHYSTDGKYFDPAHDFTIAAANVMCALCFGKRYGHDDQGVQVP 6302
6303 VNEVGQVWPRTVGAGSLVDVMPWLQSFPNPVRSVYENFKSLNEEFFSFVKNKVSEHRESF 6482
6483 DPNVTRDMSDAMINVIEGRKDSTLTKEFVEATVTDLIGAGQDTISTVMQWIILLLV 6650
6651 KYPDMQAKLHELVDKVVGQDRLPTVEDRSSLAYLDAFIYETMRFTSFVPVTIPHSTTSDV 6830
6831 TIEGLHIPKKDTVVFINQWSVNHDPLKWEG
6919 PHVLGPSRFLDDNGDLKKDLNKGVMIFSSGKRRCIGNQIAK 7041
7053 FLFTAILLHQCSFESNPSDPVTLDCSYGLTLKPLRCFVNAKPRGKLLGVVSPA 7211
CYP1C1 Anguilla japonica (Japanese eel)
No accession number
Itakura, T. and El-kady M.A.H.
Submitted to nomenclature committee 10/17/2003
Full length sequence 100% match to frag on AB048941
80% to 1C1 fugu 76% to 1C2 fugu 52% to 1B1 fugu
clone name Japanese eel 1C
CYP1C1 Anguilla japonica (Japanese eel)
GenEMBL AB048941
81% to 1C1 78% to 1C2 fugu
VSTLLQWILLLLVKYPHIQAKLQEQIDKVVGRDRLPCMEDKSSL
AYLDAFVYETMRFTSFVPVTIPHSTTSDVTIEGVHIPRDTVVFI
CYP1C1 Cyprinus carpio (common carp)
No accession number
Itakura, T. and El-kady M.A.H.
Submitted to nomenclature committee 10/17/2003
Full length sequence 2 aa diffs to frag on AB048943
77% to 1C1 fugu 73% to 1C2 fugu 50% to 1B1 fugu
clone name carp1C1a
CYP1C1 Cyprinus carpio (common carp)
GenEMBL AB048943
80% to 1C1 and 1C2 fugu
VSTVMQWILLLLVKYPSIQTKLQEQIDKVVGRGRLPSIEDKSNL
AYLDAFIYETMRYTSFVPVTIPHSTTSDVTIEGLHIPKDTVVFI
CYP1C1 Callorhinchus milii (elephant shark, Chondrichthyes)
Trace file 1576746999
57% to 1C2 tetraodon, 53% to 1B1 Pleuronectes, 49% to 1B1 fugu
This genomic fragment spans the location of 1B1s only
intron w/o an intron therefore this is probably 1C, an intronless gene
LVTVRTLYRDFKRLNQEFFGFVSGKVGQRRRTFVPGRTRDMSDAFIAVVDGAAAAGHGLS
GEHVEGTVNDVMGAGQDTTSTALGWVLFHLIRHPDVQARLQEEMDRAVGRGRLPGTGDRG
RLPYLQAFIHEVCRFTSFVPLTIPHATTSRVTLHGYDLPEDTVVFVNQWSVNHDGAKWKE
PETFEPGRFLDPDGSVNRALADSVMIFSAGKRRCLGDQLAKTQMFLFTAILIHQCAFEAN
PGDVLSLDCLYGLSLKPLPFKLRVRLRDTYRGVGRQREPPPPPTHTHTQKHSTGQGHTHR
DPSPTHTQRERDSQQDRDPTHHTPHRPLSTPVINVRN
CYP1C1 Petromyzon marinus (sea lamprey)
Trace files 1434207733, 1193330571,
1179606703, 1483258470, 1194048496, 1482130588, 1161783303, 1206198102
1193734487, 1468865778, 1293288933, 1162763713
53% to 1C2 Fugu 48% to 1B1 fugu (no intron so probably 1C)
MTAAESMEALPVVAAGGGAQLWDISHPPV
LFFLLSALLILLVTLEARKHGRSHQQQQKHSAPDPPGPLGFPIVGNSLQLGPM
PHLTLNAMAQRYGAVFRIHLGHEPVVVLTGEEI
IHEALVKRGAEFAGRPDFPSFALVSGGNSMSFKTYSELWRVHRRLAHSTLRAF
FTGTAATRRVFEGHVRLEAAELCAMLAEATSRAGGCGVDPSEPTVVAVANVISAVCFGKR
YEHDDAEFRGLLRNNERFSKTVGAGSVVDVMPWLMRFPNPVRSIFRDFEQMNNEFFAFVQ
RKVREHRDSYDPAATPRDMIDALIGHIDGGGGDSDDEGDAADGPSWRWRCARGAPEVGAA
YVDSTLTDVFGAG
QDTMSTSLMWFVLLCAKHPELQADMQRDIDRVVGRERLPRLDDRPQLACVDAFVCEMMRH
VSYVPFTIPHATTTDTELNGYRVAKGTVVFVNQWSVNHDPAIWRDPERFDPSRFL
DETGAALDRDLARRVMIFSAGKRRCIGYEMAKMQLFLFCSALLH
QLSISVPPGHVVSLEGVYGLSLKPKYLSVAFTPREQLLGGRPGEAEE*
CYP1C fragment Petromyzon marinus (sea lamprey)
Trace file 1483490875
frame3_ORF1 86% to CYP1C1 Petromyzon
TRRLAH
CTLRALFTGMATTRRVFEGHVRLEAAELCAMLHEQQNRAGGRGIESIERTVVAVANVISA
VCFGKRYEHEDAEFRGLLRNNERFSKTLGAGSVLEVIPWIMRFPNPARSIIREFEQMNNE
FFALMQRKVREHRDSYDPAATPRDMIDALIGHIDGGGGDSDDEGDAADG
QSWRWRCARGAPEVG
CYP1C2 Stenotomus chrysops (scup, a fish)
no accession number
Celine Godard, Maya Said, and John Stegeman.
submitted to nomenclature committee Aug. 26, 1998 full length 4/21/99
63% identical to human 1B1 over C-terminal PCR fragment
I-helix to heme
formerly 1B3, reaassigned after consultation with the submitters
and comparison to the Fugu genomic orthologs (see below)
CYP1C2 Danio rerio (zebrafish)
no accession number
contig NA2067 Length = 8014 EST CD758525
see zfish41356-444a08.p1c Zfish44625-3160d07.q1k
73% to 1C1 fugu and 74% to 1C2 fugu
MAQSDSEFSILKEWSGQIQPALIASFI
1098 ILCCLEACFWVRNITLKKKRLPGPFAWPLVGNAMQLGQMPHITFSKLAKKYGNVYQIRLG 1277
1278 SSDIVVLNGESAIRSALLQHSTEFAGRPNFVSFQYVSGGTSMTFASYSKQWKMHRKIAQS 1457
1458 TIRAFSSANSQTKKSFEKHIVAEAVDLVETFL 1553
KIQHFNPSHELTVAAANIICALCFRKRYGHDDLX (from EST CD758525)
(C-terminal inverted)
2818 IKNVLGNVNKFSETVGAGSLVDVMPWLQTFPNPIRSIFQSFKDLNSDFFSFVKGKVVEHRL 2636
2635 SYDPEVIRDMSDAFIGVMDHADEETGLTEAHTEGTVSDLIGAGLDTVSTALNWMLLL 2465
2464 LVKYPSIQSKLQEQIDKVVGRDRLPSIEDRCNLAYLDAFIYETMRFTSFVPVTIPHSTTS 2285
2284 DVTIEGLHIPKDTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGALDKDLTNSVMIFSI 2105
2104 GRRRCIGDQIAKVEVFLISAILIHQLTFESDPSQDLTLNCSYGLTLKPFDYKISAKPR 1931
1930 GSIVN* 1913
CYP1C2 Fugu rubripes
No accession number
Scaffold_3008a comp(5208-6770) no introns complete gene
83% to scup 1C2 78% to scup 1C1
6770 MEEDFGVKGSSSITREWSGHVQPALVAFFVFLFCVEACLWAKNLKRRL
6626 PGPFAWPVVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGCSDI 6498
6497 VVLNGARVIRQALIEHSTEFAGRPNFVSFQNVSGGKSMAFTSYSKQWRMHRKIAQSTIRA 6318
6317 FSSANSQTKKVFEQQIVAEATELVEVFLKLGARGQHFNPAHELTVAAANVICALCFGRRY 6138
6137 GHDDQEFRDVLRRIDKFGQTVGAGSLVDVMPWLQSFPNPVRSMFRSFEALNREFFGF 5967
5966 VQLKVEQHRETFDPEVTRDMSDAIISVLEKSDGETALTKDYTEVTMADLIGAGLDTV 5796
5795 STALHWMLLLLVKHPELQSKLHQLIDRVVGRNRLPSIEDRSSLAYLDAFIYETMRFTSFV 5616
5615 PVTIPHSTTSDVTIEGLRIPKDTVVFINQWSVNQDPLMWKDPHVFDPSRFMDEEGSLDRD 5436
5435 LACNVMIFSAGKRRCIGDQIAKVEVFLFFAVLLHQCSFESSADEDLTLNCSYGLTLKPL 5259
5258 DFSITAKLRGKLLKSP* 5208
CYP1C2 Tetraodon nigroviridis (freshwater pufferfish)
No accession number
84% to CYP1C2 fugu 73% to CYP1C1 fugu
CNS_TRUECNSCONTIG_6508_2 Length = 4645
1369 MEEEFCVEGGSSSIREWSGHIQAALVAFFVFLFCLEARLWAKNL
1501 KRRLPGPFAWPVVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGCSDIVVLNGDRVIRQAL 1680
1681 IQHSTEFAGRPNFVSFQTVSGGKGMTFSSYSKRWKMHRKIAQSTIRAFSSANSQTKENFE 1860
1861 QQIAAEATELVEVFLKLSARGQHFNPEHELTVAAANVICALCFGKRYGHDDAEFRELLHR 2040
2041 VNMFGQTVGAGSLVDVMPWLQSFPNPVRSMFKSFKTLNRQFFGFVQLKLKEHRETFDPKV 2220
2221 TRDMSDAIISVLDRSASEYGLTKDNAEGTVSDLIGAGLDTVSTALHWMLLLLVKHPQ 2391
2392 LQHKLQQLIDQVVGRNRLPSIGDRSSLAYLDAFIYETMRFTSFVPVTIPHSTTSDVTIEG 2571
2572 LRIPKDTVVFINQWSVNHDSLMWTDPHVFDPSRFLDEQGSLNRDLASNVMIFSAGKRRCI 2751
2752 GTQIAKAEIFLFLAILLHQCSFERSAGEEPSLDCSYGLTLKPLDYRITAKLRGKLLKSP 2928
CYP1C2 Fundulus heteroclitus (killifish)
GenEMBL AF235140
Celine Godard, Maya Said and John Stegeman
Submitted to nomenclature committee Feb. 16, 2000
Formerly named CYP1B1, but reassigned 10/21/2003
CYP1C2 Cyprinus carpio (common carp)
No accession number
Itakura, T. and El-kady M.A.H.
Submitted to nomenclature committee 10/17/2003
Full length sequence 5 aa diffs to frag on AB048943
73% to 1C2 fugu 72% to 1C1 fugu 51% to 1B1 fugu
clone name carp1C1b
CYP1D1P/CYP1A8PX human
NT_008580.9
Pseudogene 43% identcal to 1A2 human
Renamed CYP1D1P orthologous to fish 1D1
NT_008580.9|Hs9_8737 chromosome 9
4822084 MILDLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQVSPPGP*SFPIIENLLQLGDHPY 4822260
4822261 LTLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLHKDGEHFAGRPNMHTFSFLAEGKS 4822440
4822441 LSFSVNYGESWKLHKKIASKAL*TFSNAEAKSSTCSCSLEEHVTEEISELVTVFVELTSK 4822620
4822621 NGSFDPRNAITCVVANIVCALCFGKR*DHSDEEFLRIVKTNDDLLKASSAANPADFIPCL 4822800
4822801 HYLPLKIINAPLEFYQALNGFIALHVQDHLATYGK 4822905 (0)
4824790 DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVSDLFGA 4824912 (1)
4829424 GFETVSTCLCWSFLYLIHYPEIQARIQEEI 4829513 (1)
4829611 RPPRFEDRKILPYTEAFVSEVFRHASFLPFTIPHS 4829715 (2)
4832677 TTADTTLNGYFIPRKTCTFINMYQVNHDE 4832763 (2)
4835676 TIWDNHSLFRPDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITTVLQQFK 4835858
4835859 LKK*PRAKLDLTPTYGLVMRPKLYQLQAELHPSGSSSA* 4835975
CYP1D1 Macaca mulatta (rhesus monkey)
chr15 from UCSC browser 81802360-81816347
92% to human 1D1P
MILNLAVTPGEVTTSLIILVMVFVFVRALRSKGRKQLSPPGPWSFPIIGNLLQLGEHPYL
TLMEMRKKYGDVFLLKLGMVPVLVVNGMEMVKQVLLKDGEHFAGRPNMHTFSFLAEGKSL
SFSVNYGESWKLHKKIASKALRTLSNAEAKSSTCSCLLEEHVTEEVSELVTVFVELSSKN
GGFDPRNAITCAVANVVCALCFGKRYDHSDEEFLKIVKTNDDLLKASSAANPADFIPCLR
YLPLQIINAPREFYRALNGFIALHVQDHLATYDK (0)
DHIRDITDALINVCHNKYAATKTDTLNDSEIISTVNDLFGA
GFETVSTCLYWSFLYLIHYPEIQAKIQEEI (1)
DGNIGLKPPRFEDRKILPYT
EAFISEVFRHASFLPFTIPHCNTADTTLNGYFIPRKTCTFINMYQVNHDETIWDNPSLFR
PDRFLNENRELNKSLVEKVLIFGMGIRKCLGEDVARNEIFIFITAVLQQLKLKKCPRAKL
DLTPTYGLVMRPKPYQLEAERRSSGSSSASILRLRGGFLTQFRKIDELNLLN*
CYP1D1P/CYP1A8PX ortholog Bos taurus (cow)
Renamed CYP1D1P orthologous to fish 1D1
See cattle page for details
MIFGMAVTSGEVTTSRIILVMVFVFVRELGNKGRKEVFPPGPWSLPIVENLLQLG
DHLYFTFMEMRKKYGDVFLIKLGMVPVLVVNGMEMVKEVLLRNGEHFAA*PNV
LTFSFLAQ*KSLTFS
NYGENWTLHKKIASNALRTFPKAETKSSTRSCLLEKHVIEEVSELVKV
FTELTSRSGSFEPRGAITCAMANVV
CTLCFGKRYDHSDEEFLRIVKTDHDLLKASSAANPADFIPYF*YLPLRIINAPQEFYHARNQ
FIALHIRDHLTT
CPQDHIQDITDALINACHNKYAVAKITILNDDEIISTVSDLVGAG
FEIISTCIYWSFLYLIYYPEIQVKIQEEI
DGNTGMKSPRFENRKILP
YTEAFINEIFRHTSFLPFTIPHC (2)
TTADTTLNGYFIPRKTCTFINMYQVNHDE (2)
TIWDNPNLLRPERFLNENRELNKNLIEKIFIFGMGIQKCL
REEVAQNEVFVFITTVLQQLTLKKCPVVKLDLTPTYGLVMKPKPYQLPAEPRSMGSSCS*
CYP1D1P dog
UCSC browser chr 1 87915406-87928215 (-) strand
57% to human 1D1P
VIAELISKNGNFGLRSVITCVVVVVNVICILCFSMRYD
HI*EEFLRIHKMNAHLLETSSEANPADFMPCFLYRPL*IINAYQEFYQAPN*FIALHDHLTTYDN
DHI*AIADALINACHNKYGTMEAATINDDEIISTMNGLFGA
GLETIAIFLFWGFLF
IIHFFQVKTWGWESVRFEHRKIIPYTEASIN*IFRYAPFLPLAIPHC (2)
STTEDTVQNGYFIPRKSCTFISMC*INHNQ
NIWDNPKLFRSQRFINENRE*KS*EQNVDIWNGTLEVSHRR**RNEICIFITSV
CYP1D1P Oryctolagus cuniculus (rabbit)
GenEMBL AAGW01268851.1
57% to human 1D1P, only 30% to 1A1
2347 VSVFVRALGSRNRKQVSTAGP*AFSNLFQLGAYPFLI**RGERNRDVFLFTFVVLP 2514
2515 VVVVNGMEMVKKTLLSDGKHFSGRPDMHTIAFLEEGKGLSSFVTHGES*KLYFQCVSNAL 2694
2695 CTFSKVEAK
FSTYSCLLEEHITEE
ASELMKVFVELTTKSGNFG 2825
2826 LRNAIPWHDQN
2857 IVGALCFGKRYDHNDGKSLSVVK
SNGLFKFPSKAKPQ
FIPQFHYLPLQIINIP*WL 3030
3031 YQALNQFTDLQVQGHLRMYDK 3093
CYP1D1P Sus scrofa
GenEMBL CT232614.1, CT282345.1
77% to human 1D1P only 32% to 1A1 human
376 VFVFVRALRNNGRKQVFPPGSCSFPIIGNLQLGGHPYLTFMEMRKKYGVVFFIKLGVMPV 555
556 LVVNGMEMVKQVLLKGGEHVAGRLHMHTFSFLAKGKSLTFLANYRESCKLCKKIASNAL* 735
736 TFSQEETKSPTCSCFLEEHVVEEVSELVKVFAELTSNSCSFDCRSAI 876
TVVANIVFALCFGKRYDHSDEEFLRIVKT
CYP1D1 Otolemur garnettii (small-eared galago)
GenEMBL WGS seq. AAQR01460136.1 N-terminal
6245 MISHLAITPREVTISLVILVIVFVFLRVLRSKGRKQVSPPGPLSFPIIGNLLQLGEHPYL 6066
6065 TFMEMRRQYGDIFLLRLGTVPVVVVNGVEMVKQVLLKDGEYFAGRPNMHTFSFLAEGKSL 5886
5885 TFSVNYGESWKLHKKIASNALRTFSKAEAKSSTCSCLLEEHVTEEASELVKVFVELTSKN 5706
5705 GSFNPRSAITCAVANVVCALCFGKRYDHGDEEFLRIVKTNDDLLKASSAANPADFIPCFR 5526
5525 YLPLRIINAPREFYQALNRFIALQVQDHLTTYDK 5424
CYP1D1 Myotis lucifugus (little brown bat)
GenEMBL WGS seq AAPE01629621
MULTIPLE FRAMESHIFTS, BUT NO STOPS, MAY BE SEQ ERRORS
13312 MILDKAITPEEVTTSLIILVIVFVFVRALMSKGRRQVSLPGPWSFPLIGNLLQLGDHPFL 13133
13132 TFTEMRKKYGDVFLIKLGMVPVVVVNGMEMVKHVLLKDGEHFAGRPNMHTFSFLAEGKSF 12953
12952 SFSVNYGESWKLHKKIASSALRTFSKAEAKSSTCSCLLEEQVIEEVSELVKVFAELTSKK 12773
12772 GSFEPRNAITCAVANVVCALCFGKRYDHSDEEFIRIVKTNDDLLKASSAANPADFIPCFR 12593
12592 YLPLRIINAPREFYRALNEFITLHVQDHLTTYDK (0) 12491
11217 DHMRDITDALINTCHKKICTTKXXXLNDDE II STVNDIXGA (1) 11131
10594 GFETVSTCLYWSFLYLIYYPEIQARIQEEI (1)
10415 DGNIGLKPPRFEDRKMLPYTEAFINEVFRHASFIPFTIPHC (2) 10293
8366 TTADTTLNGYFIPKNTCTFINMYQVNHDE 8280
5747 TIWDIQS VFSPERFLNENRELNKSLXX 5610
5601 KVLIFGMGIRKCLGEDVARNEVFLFITMVLQQLKLHKCPRAELDLTPTYGLAMKPKPYQL 5422
5421 QAEPRSADSAS* 5386
CYP1D1 Tupaia belangeri (northern tree shrew)
GenEMBL WGS seq. AAPY01014831.1 N-terminal
1294 MIFHLAVTPGEVTITLIILVVIFVFVKTLGNKGRKRLSPPGPWSFPIIGNLFQLGDHPYL 1115
1114 TFMEMRKKYGDVFMLRLGMVPVLVVNGMEMVKQVLLKDTEHFAGRPDMHSFSFLAEGKSL 935
934 SFSVNYGESWKLHKKIASNALRTFSKAEAKSSTCSCLLEEHVTEEVSELVKVFTESTSKN 755
754 GSFDPRNAITCAVANVVCALCFGKRYDHSDKEFLRIIKTNDDLLKASSAANPVDFIPCFR 575
574 YLPLRIINAPREFYRALNKFIALHVQDHITTYDK 473
CYP1D1 Sorex araneu (European shrew)
GenEMBL WGS seq. AALT01503634.1
12376 MIFNVAVNSGDLSTSLIVFVVVFVIVRALGSKGRKQGFPPGPRALPILGNLLQLGDYPYL 12197
12196 TFMEMRKKYGDVFLIRLGMVPVVVVNGMETVKQVLLKDGEKFAGRPKMHTFSFLAEGKSL 12017
12016 SFSVNYGESWKLQKKIASNSLRTFSKAEAKSSSCSCLLEEHVLEEVSELISIFEKLTSEN 11837
11836 GSFDPRNAITCAVANIVCALCFGKRYDHSDEEFLRIVKTNDDILKASSAANPADFIPCFR 11657
11656 YLPLPIVNGPRKFYRALNQFISLHVRDHYTTYDK 11555
9964 QDHIRDITDALISTCQNKYSSKKATLNDDEVISVVNDIFGA 9842
6041 GFETVSTCLYWSFLYLIQYPEIQVKVQEEI 5952
5868 IGLKSPTFEDRKILPYTEAFITEVFRHASFIPLTIPH 5758
2010 TVDTTLNGYFIPKKTCTFINMYQVNHDE 1927
CYP1D1 Echinops telfairi (small Madagascar hedgehog)
GenEMBL WGS seq. AAIY01323088.1
1272 MMFDSAAVPGEVTASLLVLVIVFVFIRARESQEGKKIPPPGPWSFPIIGNLLQLGAHPYL 1093
1092 TFMEMRKKYGDVFLIKLGVVPVLVVNGMEMVRRVLARDGEHFAGRPAMHTFSFLAEGKSF 913
912 SFSVNYGESWKLHKKIASNALRTFSKAEAKSSTCSCLLEEHVAEEVAVLVRAFAELTSTN 733
732 GSFEPRSVITCAVANVVCALCFGKRYEHSDEEFLKVVQTNDELLKASSAANPADFIPCFR 553
552 YLPLRIINAPREFYQALNQFITRHVQDHLTTYDK
CYP1D1 Loxodonta africana (African Elephant)
GenEMBL WGS seq. AAGU01360158.1
9163 MIFSLAVTPGEATTCLIVLVIVFVFVRALRNRDGKQVSLPGPWSFPIIGNLPQIGDHPYL 8984
8983 TFMEMRKKYGDVFLIRLGMVPVVVVNGMEMVKQVLLKDGEKFAGRPNMHTFSVLAEKKSL 8804
8803 SFSVNYGESWKLHKKIASNALRTFSKAEAKSSTCSCLLEEHVTEEVSELVKVFAELTSKN 8624
8623 GSFEPRSVITCSVANVVCALCFGKRYEHNDEEFLQIVKTNDELLKASSAANPADFIPCFR 8444
8443 YLPLGVINAPRKFYQALYQFIALHVQDHLTTYDKVRI 8333
6611 QDHIRDITDALINTCHNKHAATKTATLNDDEIINTVGDLFGA 6486
24XX GFETVSTCLYWSFLYLIRYPEIQAKIQEEI
DGNIGLKSPRFDDRKILPYTEAFVNEIFRHASFFPFTIPH 2139
CYP1D1 Monodelphis domestica (gray short-tailed opossum)
GenEMBL XM_001373076.1
72% to 1D1P human
not a pseudogene Built_from_Q9PTY7_and_others
405900 - 420186 bp (405.9 Kb) on chromosome fragment scaffold_15058
This transcript is located in sequence: contig_41044
MFVIETISKEVTISFLVLMIVFIFIRALGNRNKKHMSPPGPRPFPIIGNLLQLGDHPYLTFMEMKKKYG
DVFLIKLGMVPVVVVNGTEMVKKGLLKDGENFAGRPHMYTFSFFAEGKSLSFSVNYGESW
KLHKKIAMNALRNFSKAEAKSSTCSCVLEEHVTEEASELVKIFSKLSLKQGSFDPKSSIT
CAVANVVCALCFGKRYGHFDKEFLRIIKTNEEFLKASSAANPADFIPCFRYLPLRIIHAP
REFYCQLNHFIEQHVQDHITTFDKNHLRDITDALVSICRDKSATIKTATLSDNEIISTVS
DIFGAGFETVSGFLHWSFLYLIYYPEIQAKIHEEIDGIIGFKPPRFKDRKNLPYTEAFIN
EIFRHTTFVPFTIPHCTTKDTTLNGYFIPQKTCVFFNMYQVNHDETLWENPDSFQPERFL
NEKGEMNKNLVEKVLIFGMGIRKCLGEDVARNEVFIFIVSILQQLKLKKCPEVQLDLTPV
YGLVMKPKPYQLIVEPRFHVNSST*
CYP1D1 Ornithorhynchus anatinus (duckbill platypus)
GenEMBL AAPN01253410.1 16801-19436, AAPN01253411.1 386-472
AAPN01253413.1 1531-1812
74% to 1D1 opossum
MIPGELTTSLLMLVIVLISINVLRNRGQKPPSPPGPWALPVIGNLLQLGEHPYLSFIEMR
KKYGDVFLIKLGMVPVVVVNGMEPVKRVLFQDGENYAGRPNMHTFSFFANGKSLSFSTNY
GDSWKHHKKMAINALKSFSKAEAKSSTCSCLLEEHVCGEVSELVKIFTELTATQGNFDPR
GSLTCAVANVVCALCFGKRYEHTDEKFLKVIKINDDLLKASSAVNPADFIPCFRYLPLRV
VNAPREYYHMLNQFIMQHVQEHYVTYDE (0)
GYLRDITDALISICYDKNSTGKTPILPDDTIISTVNDIFGA (1)
GFDTVSTCLNWSFLYLINYPEIQTKIQAEI (1)
DGNIGLKPPRFEDRKNLPYTEAFINEIFRHTTFLPFTIPHC (2)
TTADTILNGYFIPQKTCVFVNIYQVNHDE (2)
TLWEKPDLFRPERFLNENGELNKGLVEKVLIFGLGIRKCLGEDVARNEIFIFITNVLQHL
KLEKCSGAQLDLTPVYGLSMKPKPYHIKAEPRF*
CYP1D2P Ornithorhynchus anatinus (duckbill platypus)
GenEMBL AAPN01177473.1
87% to CYP1D1 Ornithorhynchus
processed pseudogene no introns
DDTIISTANDIFGAGFDTVSTCLSRRFL*LINYREIQTKIQAEIDGNIGQEPPRFEDRKNLP
FTEGFINEIFRHTTFLPFTIPHCTTADISGYFIPQKTCIFVNKYQVNHDETLWENPDLFRPERFLNEN
CYP1D1 Anolis carolinensis lizard
FG695750.1 FG777243.1 FG739979.1 FG695729 ESTs
Genomic AAWZ01004734.1
63% to 1D1P human
MFFSTEVSFSEVTITLFVVAAIFISIHMLMKTKRPHPPGPWSLPILGNLLQVEEHPYI 231
SFQRMRKKYGDVFQIKLGMVPVVVVNGLDAVKQVLLRDGESFAGRPDMHTFSFFADGDSM 411
SFSVNYGESWKLQKKIAGRALKLLSKSEAKSSTCSCLLEEHVCDEASELVKILLELSKN 588
GGFDPAAVTTCTAANVVCALCFGKRYNHNDEEFLGVIKLNDDFVKASSAFNPADFIPCLR 768
YLPLPAAKVARTFYRKLNDF 828
VSACVEYHCTTYDK (0)
NYVRDITDALINVGNEKKEDGKTAALSDKKIISTVNDIFGA (1)
GFSTVSACLLWIYLYLISKPEIQTKIQEEI (1)
GLRPPRFDDRKYLHYTEAFINEIFRHCSFLPFTIPHC (2)
STTRDAVLNGYYIPQSTCIFINMYQVNHDE (2)
RDVWEDPYSFKPERFLNESGELNKSLVEKVLIFGMGIRKCLGEELARNEVFVIITTIL
QQLRLEKPPEDKLDLTPMYGLTMSPKPYRLQAALRT*
CYP1D1/CYP1A8PX ortholog Xenopus tropicalis (frog)
This is not a pseudogene in frogs
It needs a new subfamily name, since it is
Separate from the CYP1A subfamily
Renamed CYP1D1
DN053435 DN024870
DN024871 mate pair to DN024870
DN025714.1
51% to CYP1A8P ortholog
MESAVKKTLMDMMPMLLKASISFLTVLLVMSILWKKRNSLPGPWAVPI
VGNFFQLGDQIHITLTDMRNRYGDVFQIKLGLMPIVVVSGLETVKRVLLKEGENFADRPN
FYSFSLFSNGSSMTFSEKYGESWKIHKKIMKNALRNLSNESTNSSNCSCRLEEYVCAEAS
DLVQELTDLSAEKVAFDPSQSIVITVANVVCALSFGKRYDHHDKEFLTLIDFNNDLRKA
AGGGLLADFIPILRFIPSSSVKALKKFVQSFHSFIAKCVKDHFATFEENNIRDITDA
LIQLCKERKSEDKNQLLSDDQIISTVNDIFGAGFDTITSALLWAIFYLLRYPEFQDKIHK
EIEEKIGCNRAPRFNDRKDLHYTEAFINEVLRHSSFVPFGLPHCTTMDTKLNGYFLPKGT
CVFTNLYQVNHDNTVWKDADMFMPERFLDQNGQIIKSLTEKVLVFGMGVRKCLGEDVARN
EMFVIMTIMMQRLKLVKSTKHELDPIPVYGLTLKPKPYYLVAKVRT*
CYP1D1 Danio rerio (zebrafish)
GenEMBL NM_001007310 5 introns
Note: CYP1C has no introns, 1B1 has 1 intron (not shared with 1D1)
CYP1A zebrafish has the same five introns
50% to CYP1A7 Xenopus, 49% to mouse Cyp1a1, 46% to 1A zebrafish
41% to 1C2 zebrafish, 36% to 1B1 zebrafish
89108 MNLENISHTATSEVTLILCAFALLLLALHGRRRAPGVPVPPGPRPWPIVG
NFLQMEEQVHLSLTNLRVQYGDVFQVKMGSLVVVVLSGYTTIKEALVRQGDA
FAGRPDLYTFSAVANGTSMTFSEKYGEAWVLHKKICKNALRTFSQTEPKDSNASCLLE
ERICVEAIDMVETLKAQGEEFGDSGIDPVQLLVTSVANVVCTLCFGKRYSHNDKEFLT
IVHINNEVLRLFAAGNLADFFPIFRYLPSPSLRKMVEFINRMNNFMERNIMEHLVNFDT (0) 89938
94917 NCIRDITDALIAMCEDRQEDKESAVLSNSQIVHSVIDIFGA (1) 95039
95618 GFDTIITGLQWSLLYLIKFPNIQDKIVQEI (1) 95707
98382 DNQVGMDRLPQFKDRPNMPYTEAFINEVFRHASYMPFTIPHC (2) 98507
98613 TTENITLNGYFIPKDTCVFINQYQVNHDI (2) 98700
101355 EIWDDPESFRPERFLTLSGHLNKSLTEKVMIFGMGIRRCLGDNIARLEM
FVFLTTLLHRLHIENVPGQELDLSSTFGLTMKPRPYRIKIIPRN* 101636
CYP1D1 Pimephales promelas (Cyprinid fish)
GenEMBL DT309726.1 EST testis
About 80% to zebrafish 1D1
69 MYLEEISRTTNVTSGLTLFLCAFALLLLALHGRRRGPGCSFPPGPKPWPLVGNLFQMGEQ 248
249 IHLSLTNLRVQYGDVFQVQMGSLVVVVLSGYSTIKEALVRKGEAFAGRPDLFTFSAVANG 428
429 TSMTFSEKYGEAWVLHKKICRNALRTFSQAEPRDSSASCLLEEHICTEAMEMVKALKEQG 608
609 DK 614
missing some sequence here
614 GNLADFFPIFRYLPSPSLRKMVQHIGRMNSFMECNIREHLITFDRNCIRDITDALIAMSE 793
794 DRQEDEETAMLSNSQIVHSVIDI 862
CYP1D1 Callorhinchus milii (elephant shark, Chondrichthyes)
GenEMBL CW874708.1 CW863449.1 GSS sequences
AAVX01473941.1 WGS
Trace archive files 1573350467 (exon 5) 1574214913 (exon 6)
1573943089 (exon 2)
About 67% to Gasterosteus aculeatus (stickleback) 1D1
PVEPITSTVANVICALCFGKRYEHNDKEFLNIVHTNHEVMRTFASGNVADVFPFFRYLPS
PSLKSMIKFVNRLNNFMIKSIQEHYTTFDK
GFDTIITGLQWCLLYLIQYPEFQTRIQQEI (1)
144 DEKVGQSRLPRFEDRTLLPFTEAFINEVFRHTTYMPFTIPHC (2) 19
TTASTTLNGYFIPKDTCVFINQYQVNHDE (2)
CYP1D1 Oryzias latipes
GenEMBL BAAF03028505.1 WGS seq
69% to zebrafish 1D1, only 48% to CYP1A
25653 MLSGTLPIA
25626 ESLSASLSSVTVVLFLIALGLMAIRVQKSRSSPFNVKDDSHLDLTAFPSPPGPTPWPIVG 25447
25446 NLFQMGNQMHLSLTLLRAKHGDVFK (0)
24429 LRLGSLPVVVLSGYNTIRQALVRQGEDFAGRPELFTFSAVADGTSMTFSEKFGPAWLLH 24253
24252 KKLCKNALRSFSQAAPRGSGATCLLEEHVCAEAAEMLEMIREQSAKVELDSEMTDGASKG 24073
24072 VDPVKPLVTSVANVVCALCFGKRYDHNDKEFLTIVNINNEVLKLFAAGNLADFFPVFRYF 23893
23892 PSLSLKELVQYIRRMNGFMERRIEEHMHTFDK (0) 23800
23189 NYIRDITDALIALCEDREKSKEMSLLSDTQIIHSVIDIFGA (1) 23067
22979 GFDTIIAGLQWSLLYLIKFPDVQRRIHQEI (1) 22890
20183 DEHIGSARMPNFSDKSKMPFTEAFIYEVFRHAAYVPFTIPHC (2) 20058
19961 TTRHTTLNGYFIPKDTCVFINQYQVNHDK (2) 19875
19791 DLWGDPEQFCPDRFLGHSGQLNKELTEKVLIFGMGKRRCLGDGFARLEMFVFLATLLHGL 19612
19611 RIENVPGQKLDLGTDFGLTMKPHPYKITVSSRFTEM* 19501
CYP1D1 Gasterosteus aculeatus (stickleback)
GenEMBL AANH01001861.1
77% to Oryzias 1D1
54662 MRVTFGIFPIKENTCASLSSVTVVLCLINLLLMALVCRKNHCHNSRLDHTKYPTPPGPT 54486
54485 PWPLVGNLLQMGDQIHLSLTRLRLQYGDVFK (0) 54393
54293 MRLGSLTVVVLSGHNTIRQALVRQGEAFAGRPDLFTFSAVANGTSMTFSEKYGPAWMLHK 54114
54113 KLCKNALRSFSRAEPRESGATCLLEEHVCAEAAEMVEVMYEQAAAEREMGHKVMGI 53946
53945 DPVVPVVTSVANVVCALCFGKRYDYNDKEFLTIVHINNEVLRIFAAGNMADFFPVFRYFP 53766
53765 SPSLRKMVQHIQRMNGFMERSIEEHINTFDK (0) 53673
53010 NYIRDITDALIALCEDREENQDTSLLSKSQIIHTVVDIFGA (1) 52888
52795 GFDTIIAGLQWSLLYLIKYPDIQDRIHQEI (1) 52706
51800 DDHIGIARLPMFSDKPKMPFTEAFMYEVFRHASYVPFTIPHC (2) 51675
51589 TTRNITLNGYFIPKDTCVFINQYQVNHD (2) 51506
51396 DLWGDPDRFRPARFLGSLGLLNKELTEKVLIFGVGKRRCLGDGLARLEMFVFLTTLLHRT 51217
51216 RIENVPGQQLDLSTDFGLTMKPRPYRITISSRF* 51115
CYP1E1 Ciona intestinalis (sea squirt)
JGI Ciona genome ver.2 gene model 131189
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1As, but only about 33% identical to CYP1As
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
MMITAAILLDAGRSFAVPVAFTAVSVLTLYVCLRKRQGIPPGPTAWPLVGNL
FSMGRQSHLILESMRKTYGDVFSVYFGSTLVVVVNGKAVEECLSTHSAR (2)
YSMRPELHTAQYILEGKSFAFSHIAVSKHKRYRTLAVAVVKQLVNGGGEKTDVAV
KHGLQNGTRHSSIEERIFMEAACMCDKLLETSDSPDLKDEILKVITKEL (2)
LSEYELDEISRVVENLRNSNEAIMLVNFIPAVRMLWRNGLQKYIQLTQSLNR (2)
FFERCIRNRKAQLATVSNGHTEDNGVRLTNGVDCTVKFWQKLKNDPQYEESRVMKV (0)
VADLFGARVDTMTVALAWMIVYWSTYQAAQERAQKEIDHFVKNEKRLPR (2)
YSERNQLPYTMALIMEVERHCSFVPFTLPHAPAQDTMLNGYLIPKGTMMLISMRSINHDTAVWDSPAQFR (2)
PERFLLDQSGGFNSALAEQVMLFGAGRRRCAGEALGRMQIFLYSVLFLRKCTFRR
SDKDGHVLPESLAGISLIPQTMCVSISRREADGSKNTEP*
CYP1E1 Ciona savignyi (sea squirt)
Ortholog of C. intestinalis CYP1E1
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1As, but only about 33% identical to CYP1As
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
75% identical to C. intestinalis CYP1E1
paired_scaffold_63
595236 SICLPITAFALSLIYLHRRKRDNLPPGPFAWPVLGNLLSLRSNSTAALEEIRRTYGDV 595063
595062 YSLYFGSRLVVVVNGKAVEECLSTRSAK 5949795
594724 RFSMRPELFTAQYVLGGKSFAFSHMDVETHRRYRKLAVGVVKELLVSTHERSQPTTMEEV 594545
594544 NRIPPQSIEDQIYAQAKRLCVGLFDIYASNSKSGQLDIRKEIMRRISFEM 594395
594161 LWEHELADLSELVEDLRNSNDATLILNFIPISRYLWKKGLRKYIKINQDLNK
592629 FFSRCFDRRNPHVANGSDCCKSEETCDVLSGIDCVLKLWQQLKDDPQFEENRVMKLVRKLFKCN 592438
591699 VGDLFGANVDTMTVALAWMIVYWSTYHQAQTRAQEEIDRFVETNFHLPRY 591550
591042 RYSDRSQLPFVMALIWEVARHCSFVPFALPHAPVEDTTLNGYLIPSGTVMMISMRSVNHDQTLWDS 590845
590844 PGEFR 590830
590562 PERFISSETGVFNKGLADRVMLFGGGRRRCAGEALARMQLFLFSVSILRSCTIRRVDHS 590386
590385 DVLPD 590371
CYP1F1 Ciona intestinalis (sea squirt)
JGI Ciona genome ver.2 gene model 136792
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to CYP1Bs
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
MLVQILTATFWTLIP
NSFGDLLIYAILVLTIVIYVKSLKRDKEWLALPGPIPW PLVGNA PFLGAEPHKKLLELSL
KYGPVYRLKMGGIKTVVLCNAEVVRSALIKQREAFSGRPKFSSYKAVS AGESVVFNDEET
LPP WRSH KSKIVRHMHKYTTSIRTRDKVTDLINTECMMMVTELDRISRSKCVNPENVIRM
ALANVMCAVCFGNRFEYDNE (0)
EFQKLLSMNTEFGAVIELGPIIDAMPWIK (0)
VIPKFKKAIADYLKINLQLDTWSRHR (2)
VDGVLKTFDNDDVTNVVASMTSEVLEKKSAGESREITESETKTIAALSADILGA
GQHTTSTTFFWVINLLLCFPKVLNKLTEEVRSKLGNRLPTLEDRTSLPYMDAVLTE
VLRFSSPLSSTIPHSTLKDVKLAGHTIKRGTMVIISQYAVNHDPQNWKNPENFDPERFLTK
NEGGEIIFNESLSEKVLAFSIGERKCPGSQLSRMLLFLATTLLVQVSDLSADLERPPT
AAAEYGLILRPKHLSIKLTLREHWQRRDSIRA*
CYP1F1 Ciona savignyi (sea squirt)
Ortholog of C. intestinalis CYP1F1
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to CYP1Bs
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
paired_scaffold_56 66% to C. intestinalis CYP1F1
957040 VLIYISMVSIVVIYVKSVKRNKEFMALPGPTPWPIVGNAPFLGKQPHKTLLQLSQK 956873
956872 YGPIYRLKMGSVEAVILCDLDVIRCALIKQREVFSGRPKFESYKAVSAGESVVFNDSESL 956693
956692 APWKSHKSKILRHLHKFATSVRTKEKVNNIITTECMLMLQCLHRRSQDGFVDPEDVIRMT 956513
956512 IANVMCAVCYGNRFEYENE 956456
950636 GQHTTSGTFFWVINILLFYPKVLQRITNEVRSKIGERIPTLEDQADLPYVEAFLTEV 950466
949639 VLRFASPLSSTIPHSTTKDTTLKGYKIKRNTMVIISQYSVNHDPKIWRNPEVFDPERFLTRDENTNLVFND 949427
949426 ALAEKVLSFSVGERKCPGSRMSQMVLFLATCLLVHTGTLYPNPDRPPS 949283
949282 PVDDAQYGLILRPEYISMKFLLDKKW 949205
CYP1F2 Ciona intestinalis (sea squirt)
JGI Ciona genome ver.2 gene model 143263
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to CYP1Bs
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
MDSLVFVLVDTVLVMKYQILLLLVIVYAIKLLAASQSRRLNIPGPYPWPVIGNVIEMGGQPQFSLTNMAK (?)
RYGPVYLMKLGTADVLVLNNYEVIKEALLRQRRIFGGRPIFDSFKKISQGLGVVFNSTMT
QGDEWMKLKMTIVKHVHRFVSSEETKGYVAHHVQMEAVELVRILTEKCRS
SPNEVIFPIEQINLAIANVVCAIMFGHRYQHGNK (0)
EFQDLISLNEQFGDVIGSGSQVDVIPWMK (0)
IFPKFRNALKVFDFLTNRLNNWMRLR (2)
TKEHRLTYKHGVIRDIVDSFIAESIDHPEQSALNDDVIMALTTDVFGA
GQDTMSTTMQWVFVYMMHFKECQRK
IHAELDSVIGPGELPHISDRRRLPYLEAVMHEIFRHSTFTSTTIPHVTTQDTVLDGHFIP
KGILVFINQFGANHDPNHWVDPDKFIPERFLDGKGNLISRPHDRYLLFSTGARKCPG
DELSRMLILHFMATMFALCEVSSDPQKPATL
DAVYNLSMRPKELRTIVRS
RNLPFLKNSVAQMSEADSHVLTVPGETTSFLTSRVESTVPDNQESQFSDNDFEKVDTKIP
KRKVFSRPTLTHDDINGNNVRKRGNLHQSAMYRIQLAT*
CYP1F2 Ciona savignyi (sea squirt)
Ortholog of C. intestinalis CYP1F2
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to CYP1Bs
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
paired_scaffold_142 77% to C. intestinalis CYP1F2
222183 FRRYGPIYLIKLGTADVLILNNYDVIKEALIRQRGVFSGRPVFESFKKISQ 222031
222030 GRGIVFNSSLTQGAAWQRMKMTIVKHLHRFIASPQTKGFVAGHVQKETVQLVHILSEKCR 221851
221850 SSTNQAIEPVENINLAVANVVCSIMFGHRYQHGNK 221746
219363 LHRTREHRQSYKHGVIRDLVDSFIAESIDKPGQLLNDDVIMALTTDVFGAGQDT 219202
219201 MSTTLQWIFVYMMRFKECQKK 219139
218667 IHAELDSVLKPGSLPQIKDRARLPYLEAVMHEIFRHSTFTTTTIPHVTTEDTVLRGYHLPKET 218479
218478 LIFINQYAANHDPEHWVEPDKFIPERFLDEKGNLISRPHDRYLLFSTGSRKCPGDELSRM 218299
218298 LILYLMANIFTLCEISPDPNQPTTLDAVYTLSMRPKNVKTVVRVR 218164
CYP1F3 Ciona intestinalis (sea squirt)
JGI Ciona genome ver.2 gene model 138492
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to vert CYP1s
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
LPYPRGLPIIGNIHQMGNFPHVKLTEWSKQFGDFYRIKMGRYDALVVNGHENIR (2)
NCLAKKSAAFAGRPPFETSKLIEEGLSISFSNYS (2)
PEWERQKQCTIKALKLYTSGSDKRSTMEETVSSHAKQLAEDLINSADQQ (0)
GLVGDLHDTVIYSTTSVSSTICFGRSFTRQDPELKEFLRNFQSFDKAMGASQIINFWPFLKYFPVLGKSFR (0)
NLKTYMDQYWNFTLSMLEQHWDTYVPNNMRDLADCLWAQSNQ (0)
NRQLTDQQRRIAYGASDAFGAGFDTISAMITWSIFYMAVFPEHQRK (0)
IREEIDRLETSMFSLRHHGDVCPYTQAWLYEVLRH
ISVSPLLVPHYTVKQVEVNGTMIPAGVVVLFNVAN (0)
ADRDTRVWENPEQFEPERFLARDPTTGGARVVASETSKI
LNWGAGKRRCPGAELSRHELFIYIANLVKLCYIE
QAVEGIEPAIPWPCTPGISTKPKAFRVKVTQR*
CYP1F3 Ciona savignyi (sea squirt)
Ortholog of C. intestinalis CYP1F3
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 33% identical to CYP1Bs
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
paired_scaffold_3 56% to C. intestinalis CYP1F3
LPSPRGLPIIGNVHQLTTSPHVKLSEWAKEFGDLFRIKMGCFDTLVVTGYDNIR
(2) TALVKHSVAFAGRPPYETSKLFSNGLSLAFNNY
(2) SPAWEKQKRCTVKALKLYTAGPDLQKRNAMEDTASYQANLLVDQLLASVNK (0)
DAITNPDEIVHHSATNVISNICFGRSFSKNDPELQKFVSINRAFDRAMGSAQIVNFWPFLKSVPVLGRSYQ
NLKAHMDVFWDFVFPNLKEHWKTYNPSNIRDIADCLWYQSH
TSSKRDLQRRIASAASDIFGAGYDTTHKVVLWSLFYMAAFPQYQQKV
RDIFRVSEVKMY
TLRHHGDECPYVQAWIYEVLRHTSLAPILLPHYTTKEVTLNGVRIPAGVV
KKYHTIQAHKDPKIWKNPDEFDPGHFLEEDGSKLRSEAVHKLLSWGAGKRRCPGAELSRHE
IFVFVTTLVRRAYIGQAVDGVEPAFPWNTTGGISISPDPFRVKITER
CYP1F4 Ciona intestinalis (sea squirt)
JGI Ciona genome ver.2 gene model 132188
Clusters inside the vertebrate CYP1s on NJ trees
Closest to CYP1Bs and CYP1Cs, but only about 29% identical to vert CYP1s
Note: the Ciona genome is greatly diverged from the
Vertebrate line and seems to be undergoing rapid evolution
No ortholog is found in C. savignyi
MESVWVVIKWVKETMMSNSSFETIVAVATLLLLLMFVSENWNWLKIPGPI
PWPIIGNLGSLKGTKFLSIHEMYKIYGRIFRLKFGRVEAVVLCDVELIKE
ALLDRGRSLSGRPQFASYRLVSGCKSVVTNDPRCLREWVNY
KSTMVQTLCSISKNNEMKELMNERIGSVLVYMIQELEKGGDGQNFAEDIVTKTVANFLCT
VCYGGTYDFNSK (0)
EFNNLIEMSRHYTDNLSKSILRDMIPLAE (0)
ILPSVNKGRADFAKTSYHLHLWFLKR (2)
VEEVIQHFQPNKLNDLASVMVSDLTNDPTENISNITEKDRNSIAAIINDLVQ (1)
GYHSLYSMALWVVTYMIKYPEEVKKIENELNEVLDDYLPTLHDQESLPHTMAFINE (0)
VLRCRPSLPLAVPHSATEDTKLGGYDISKDTMVVASLYSANRDPKVWANPDQFDPSR
FLAKDDLGVTVLDETKVEQVFTFSLGDRKCPGEDIGRSFLFLTTAYLAHTCKLKPDPAK
PPTFQTKPGSITRPKDFGVQLNVKKCWLGVFKPDDNEE*
2A Subfamily
CYP2A1 rat
PIR C41425 (12 amino acids)
Imaoka, S., Kamataki, T. and Funae, Y.
Purification and characterization of six cytochromes P-450
from hepatic microsomes of immature female rats.
J. Biochem. 102, 843-851 (1987)
CYP2A1 rat
GenEMBl J02669
1 aa diff to genome seq (lower case)
82084958 MLDTGLLLVVILASLSVMLLVSLWQQKIRGRLPPGPTPLPFIGN
YLQLNTKDVYSSITQLSERYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGE
QATYNTLFKGYGVAFSSGERAKQLRRLSIATLRDFGVGKRGVEERILEEAGYLIKMLQ
GTCGAPIDPTIYLSKTVSNVISSIVFGERFDYEDTEFLSLLQMMGQMNRFAASPTGQL
YDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQE
EKNGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHPDVEAKVHEEIEQVIG
RNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPKaTDVFPI
LGSLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFSTGKRFCLGDGLAKMELFLL
LTTILQNFRFKFPMKLEDINESPKPLGFTRIIPKYTMSFMPI
CYP2A1 rat
NP_036824 88% T0 2A2 chr1 (+) Cyp2a22 ortholog
82084958 MLDTGLLLVVILASLSVMLLVSLWQQKIRGRLPPGPTPLPFIGNYLQLNTKDVYSSITQ 82085134
82085434 LSERYGPVFTIHLGPRRVVVLYGYDAVKEALVDQAEEFSGRGEQATYNTLFKGY 82085595
82088031 GVAFSSGERAKQLRRLSIATLRDFGVGKRGVEERILEEAGYLIKMLQGTC 82088180
82088398 GAPIDPTIYLSKTVSNVISSIVFGERFDYEDTEFLSLLQMMGQMNRFAASPTG 82088556
82089778 QLYDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQE 82089957
82093158 EKNGNSEFHMKNLVMTTLSLFFAGSETVSSTLRYGFLLLMKHPDVE 82093295
82093737 AKVHEEIEQVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPK 82093925
82094440 GTDVFPILGSLMTDPKFFPSPKDFDPQNFLDDKGQLKKNAAFLPFST 82094580
82098022 GKRFCLGDGLAKMELFLLLTTILQNFRFKFPMKLEDINESPKPLGFTRIIPKYTMSFMPI 82098201
CYP2A1-de2b rat
exon 2 pseudogene Chr1 (-) only 240 bp from CYP2A1 start Met
frag e in fig below
82084718 YNAVKEALVDQAEGFSGQGEQA 82084653
rat, mouse and human 2ABFGST clusters
CYP2A2 rat
PIR S26821 (27 amino acids)
Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
Purification and characterization of three male-specific and
one female-specific forms of cytochrome P-450 from rat
liver microsomes.
J. Biochem. 100, 1359-1371 (1986)
CYP2A2 rat
J04187 Cyp2a12 ortholog
82117349 MLDTGLLLVVILASLSVMFLVSLWQQKIRERLPPGPTPLPFIGNYLQLNMKDVYSSITQ 82117525
82117991 LSERYGPVFTIHLGPRRIVVLYGYDAVKEALVDQAEEFSGRGELPTFNILFKGY 82118152
82123228 GFSLSNVEQAKRIRRFTIATLRDFGVGKRDVQECILEEAGYLIKTLQGTC 82123377
82123595 GAPIDPSIYLSKTVSNVINSIVFGNRFDYEDKEFLSLLEMIDEMNIFAASATG 82123753
82124978 QLYDMFHSVMKYLPGPQQQIIKVTQKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQE 82125157
82139054 EKYVNSEFHMNNLVMSSLGLLFAGTGSVSSTLYHGFLLLMKHPDVE 82139191
82139607 AKVHEEIERVIGRNRQPQYEDHMKMPYTQAVINEIQRFSNLAPLGIPRRIIKNTTFRGFFLPK 82139795
82140311 GTDVFPIIGSLMTEPKFFPNHKDFNPQHFLDDKGQLKKNAAFLPFSI 82140451
82141451 GKRFCLGDSLAKMELFLLLTTILQNFRFKFPMNLEDINEYPSPIGFTRIIPNYTMSFMPI 82141630
CYP2A2-de2b rat
exon 2 pseudogene Chr1 (-) frag f in fig below
82115528 LKPHWVVVLYEWDAVKEALGDQAEELSG*GEQANL 82115445
rat, mouse and human 2ABFGST clusters
CYP2A3 rat
J02852 NM_012542 exon 4 in a seq gap in genome seq chr1 (+)
mouse Cyp2a5 ortholog
82023007 MLASGLLLVASVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFIGNYLQLNTEKMYSSLMK 82023186
82023453 ISQRYGPVFTIHLGPRRVVVLCGQEAVKEALVDQAEEFSGRGEQATFDWLFKGY 82023614
82024296 GVAFSSGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIESFRKTN 82024445
GALIDPTFYLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTG
82026488 QLYEMFSSVMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMLE 82026667
82028068 EKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDIE 82028208
82028659 AKVHEEIDRVIGRNRQAKYEDRMKMPYTEAVIHEIQRFADMIPMGLARRVTKDTKFREFLLPK 82028847
82029417 GTEVFPMLGSVLKDPKFFSNPNDFNPKHFLDDKGQFKKSDAFVPFSI 82029557
82030741 GKRYCFGEGLARMELFLFLTNIMQNFCFKSPQAPQDIDVSPRLVGFATIPPNYTMSFLSR 82030920
CYP2A3-de1b rat
exon 1 pseudogene Chr1 (+)frag d in fig below
82052140 MLGSRLLLVAVLSCLCVMVFMPVWQQQYRDTIPPG 82052244
rat, mouse and human 2ABFGST clusters
Cyp2a4 mouse
GenEMBL J04631 (multiple genomic fragments)
PIR A30499 (494 amino acids) PIR A33531 (494 amino acids)
Lindberg,R., Burkhart,B., Ichikawa,T. and Negishi,M.
The structure and characterization of type I P-450-15-alpha gene as
major steroid 15-alpha-hydroxylase and its comparison with type II
P-450-15-alpha gene
J. Biol. Chem. 264, 6465-6471 (1989)
Cyp2a4 mouse
PIR S16067 (494 amino acids)
Squires, E.J. and Negishi, M.
Reciprocal regulation of sex-dependent expression of
testosterone 15-alpha-hydroxylase (P-450-15-alpha) in liver
and kidney of male mice by androgen. Evidence for a single gene.
J. Biol. Chem. 263, 4166-4171 (1987)
Note: 2a-4 and 2a-5 differ at 11 positions. This sequence is 2a-4 like at
9/11 positions.
Cyp2a4-de7b mouse
GenEMBL AC087157.1 + strand
w in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exon 7 between Cyp2a4 and Cyp2b9
37037 AKIHEEINQVIGTHRTPRVDDRAKMP 37114
37114 YTDAVIHEIQRLTDIVPLGIPHNVT 37188
37190 RDTHFRGY 37213
Cyp2a5 mouse
GenEMBL J04631 (multiple genomic fragments)
PIR B30499 (494 amino acids) PIR B33531 (494 amino acids)
Lindberg,R., Burkhart,B., Ichikawa,T. and Negishi,M.
The structure and characterization of type I P-450-15-alpha gene as
major steroid 15-alpha-hydroxylase and its comparison with type II
P-450-15-alpha gene
J. Biol. Chem. 264, 6465-6471 (1989)
Cyp2a5 mouse
PIR S16068 (494 amino acids)
Squires, E.J. and Negishi, M.
Reciprocal regulation of sex-dependent expression of
testosterone 15-alpha-hydroxylase (P-450-15-alpha) in liver
and kidney of male mice by androgen. Evidence for a single gene.
J. Biol. Chem. 263, 4166-4171 (1987)
Note: 2a-4 and 2a-5 differ at 11 positions. This sequence is 2a-4 like at
5/11 positions, and 2a-5 like at 6/11 positions
Cyp2a4 or 5 mouse
PIR S03979 (21 amino acids)
Lang, M.A., Juvonen, R., Jaervinen, P., Honkakoski, P. and
Raunio, H.
Mouse liver P450Coh: genetic regulation of the
pyrazole-inducible enzyme and comparison with other P450
isoenzymes.
Arch. Biochem. Biophys. 271, 139-148 (1989)
CYP2A6 human
PIR S17220 (20 amino acids)
Maurice, M., Emiliani, S., Dalet-Beluche, I., Derancourt, J.
and Lange, R.
Isolation and characterization of a cytochrome P450 of the
IIA subfamily from human liver microsomes.
Eur. J. Biochem. 200, 511-517 (1991)
CYP2A6 human
PIR A61272 (13 amino acids)
Yun, C.H., Shimada, T. and Guengerich, F.P.
Purification and characterization of human liver microsomal
cytochrome P-450 2A6.
Mol. Pharmacol. 40, 679-685 (1991)
CYP2A6v2 human
GenEMBL U22027(7215bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
CYP2A7 human
GenEMBL U22029(2282bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
CYP2A7 baboon (Papio sp.)
Swiss P80055 (20 amino acids) PIR S21737 (20 amino acids)
Purification of two cytochrome P450 isozymes related to CYP2A
and CYP3A gene families from monkey (baboon, Papio papio)
liver microsomes. Cross reactivity with human forms.
Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
Eur. J. Biochem. 204, 641-648 (1992)
MLASGLLLVALLACLTVMVL
100% to CYP2A7 human
CYP2A7PTX human (retired name see CYP2A18PN)
GenEMBL U22030(1192bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
There are two human pseudogenes of 2A7 on chromosome 19. They are
Located adjacent to each other. This one is telomeric.
CYP2A7PCX human (retired name see CYP2A18PN)
GenEMBL U22044(1192bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
There are two human pseudogenes of 2A7 on chromosome 19. They are
Located adjacent to each other. This one is centromeric.
CYP2A8 Mesocricetus auratus (hamster)
GenEMBL M63788 M34446 M34447 (1771bp)
Lai,T.S. and Chiang, J.Y.L.
Cloning and characterization of two major 3-methylcholanthrene inducible hamster
liver cytochrome P-450s.
Arch. Biochem Biophys. 283, 429-439 (1990)
clone MC1 note: M34446 is incorrectly included in this GenBank entry
and in the 2A9 entry. M34446 should only be in the CYP1A2 hamster entry.
CYP2A9 Mesocricetus auratus (hamster)
GenEMBL M63789 M34446 M34448 (918bp)
Lai,T.S. and Chiang, J.Y.L.
Cloning and characterization of two major 3-methylcholanthrene inducible hamster
liver cytochrome P-450s.
Arch. Biochem Biophys. 283, 429-439 (1990)
clone MC1-81 3 prime end
note: M34446 is incorrectly included in this GenBank entry
and in the 2A8 entry. M34446 should only be in the CYP1A2 hamster entry.
CYP2A9 Syrian hamster
GenEMBL D86953
Kurose,K., Tohkin,M., Ushio,F. and Fukuhara,M.
Cloning and characterization of syrian hamster testosterone
7alpha-hydroxylase, CYP2A9
Arch. Biochem. Biophys. 351, 60-65 (1998)
clone name P450SH2A-1
1 amino acid difference with MC1-81 of Lai and Chiang (incomplete seq.)
CYP2A10 rabbit
GenEMBL L10236 (1641bp) Swiss Q05555 (494 amino acids)
Peng.H.-M., Coon,M.J. and Ding,X.
Isolation and heterologous expression of cloned cDNAs
for two rabbit nasal microsomal proteins CYP2A10 and CYP2A11
that are related to nasal microsomal cytochrome P-450 form a.
J. Biol. Chem. 268,17253-17260 (1993)
CYP2A10/11 rabbit
PIR A31944 (23 amino acids)
Ding, X. and Coon, M.J.
Purification and characterization of two unique forms of
cytochrome P-450 from rabbit nasal microsomes.
Biochemistry 27, 8330-8337 (1988)
CYP2A11 rabbit
GenEMBL L10237 (2484bp) Swiss Q05556 (494 amino acids)
Peng.H.-M., Coon,M.J. and Ding,X.
Isolation and heterologous expression of cloned cDNAs
for two rabbit nasal microsomal proteins CYP2A10 and CYP2A11
that are related to nasal microsomal cytochrome P-450 form a.
J. Biol. Chem. 268, 17253-17260 (1993)
Cyp2a12 mouse
GenEMBL L06463 (1665bp) PIR S32491 (492 amino acids)
Iwasaki,M., Juvonen,R., Lindberg,R. and Negishi,M.M.
Site-directed mutagenesis of mouse steroid 7 alpha-
hydroxylase cytochrome P-450 (7 alpha): Role of residue
209 in determining steroid-cytochrome P-450 interaction.
Biochemical J. 291, 569-573 (1993)
Note: called 7 alpha hydroxylase, but this sequence is very
different from CYP7 sequences. It is actually a 2A sequence.
Cyp2a12-de1b2b mouse
GenEMBL NW_000310 (52646-53186) also NT_039413.1 - strand
note: nuc. numbering same in both
detritus exons 1 and 2 = s in Figure 2B
Nelson et al. Pharmacogenetics 14, 1-18 (2004)
Between 2a12 and 2f2
Old name Cyp2a20p
53186 MTLS 53175
53173 MLLVAVLTCFIAMITMSVLR*KKLLGKMPPGPTPLPFLGNFLELDTKKFYDSFLRVVGREM 52988
52810 IREWYGPVFTVHLGTYSAVVPWGYDVVKETLVDQAEQFSGRGEQAFLDWFFKGYG 52646
CYP2A13 human
GenEMBL U22028(8778bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
CYP2A13 Canis familiaris (dog)
XM_541608.2
91% to CYP2A13 human
There is a second CYP2A in dog CYP2A25 that is 87% to CYP2A13
This seq is the probable ortholog of CYP2A13
Dog cluster order 2S(-), 2B(+), 2G(+), 2A25(+), 2A13(-), 2F(+), 2T(+)
Note: this seq is the same as Seq 2 sent by Tom Rushmore
On 6/28/05 except for 3 aa diffs
CYP2A13 Canis familiaris (dog)
NW_876270.1 43229491-43235490
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
92% to human 2A13 probable ortholog
MLASGLLLVALLACLTIIVLMSVWKQRKLGGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGP
RPVVVLCGHEAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSITTLRDFGVGKRGIEERIQ
EEAGFLIEALRGTRGAFIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQLYEMFYS
VMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMQEEQNNPNTEFYLKNLVLTTLNLFF
AGTETVSTTLRYGFLLLMKHPDVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMIPMGVARRVI
KDTKFREFLLPKGTEVFPMLGSVLRDAKFFSNPQDFHPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
LFLTTILQNFHFKSPQLPQDIDVSPKHVGFATIPRNYTMSFQPR*
CYP2A13 Bos taurus (cow)
See cattle page for details
90% to 2A13 86% to 2A7
MLASGLLLVALLACLTIMVLMSVWRQRNLKGKLPPGPTPLPFIGNYLQLNTEQMCNSLMK
ISEHYGPVFTV
HLGTRQIVVLCGYDAVKEALVDQAEEFSGRGKQATFDWLFKGYGVAFSNGERAKQLRRFS
ITTLRDFGVGKRGIEERIQEEAGFLIEAFRGTRS
AFIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQ
1 LYEMFYSVMKYLPGPQQQAFKELQGLEDFIAKKVEQNQRTLDPNSPRDFIDSFLIRMQEEKENPNTEFYRK 177
178 NLVMTTLNLFFAGTETVSTTMRDGFLLLMKHPDVEAKIHEEIDRVIGKNRQPKFEDRAKM 357
358 PYTEAVIHEIQRFGDMIPMGLARRVTKDTKFRDFLLPKGTEVFPMLGSVLRDPKFFSNPR 537
538 DFNPQHFLDEKGQFKKSDAFVPFSIGKRYCFGESLARMELFLFFTTIMQNFRFKSPQS 711
712 PQDINVSPKLVGFATIPPNYTMSFLPR*
CYP2A13 frag. Bos taurus (cow)
PIR A35704 (18 amino acids)
Lazard, D., Tal, N., Rubinstein, M., Khen, M., Lancet, D. and
Zupko, K.
Identification and biochemical analysis of novel olfactory-specific
cytochrome P-450IIA and UDP-glucuronosyl transferase
Biochemistry 29, 7433-7440 (1990)
MXYLPGPQQQAFKELQGL
1 aa diff to human CYP2A13 and one uncalled amino acid
CYP2A13 horse
GenEMBL XM_001499763
Heather Knych
Submitted to nomenclature committee Oct. 21, 2007
88% to CYP2A13 human, 89% to dog CYP2A13
CYP2A14 Cricetulus griseus (Chinese hamster)
GenEMBL D86954
Fukuhara,M., Kurose, K., Aiba, N., Matsunaga, N., Omata, W., Kato, K.,
and Kimura, M.
A Major Phenobarbital-Inducible P450 Isozyme, CYP2A14, in the
Chinese Hamster Liver: Purification, Characterization, and cDNA
Cloning"
Arch. Biochem. Biophys. 359, 241-248 (1998)
clone P450CH2A-2 85% identical to 2A3 and 2a5
CYP2A15 Cricetulus griseus (Chinese hamster)
GenEMBL AB022916
Kouichi Kurose, Emi Isozaki, Masahiro Tohkin, and Morio Fukuhara
Cloning and expression analysis of a new member of the cytochrome
P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-
Hydroxylase.
Archives of Biochemistry and Biophysics (1999) Vol. 371 pp270-276
91% identical to CYP2A9
CYP2A16 Mesocricetus auratus (Syrian hamster)
GenEMBL D86952
Masahiro Tohkin, Kouichi Kurose, Emi Isozaki, and Morio Fukuhara
Molecular cloning, heterologous expression, and characterization of
a novel member of CYP2A in Syrian hamster"
Biochimica et Biophysica Acta (1999) Vol.1446 pp438-442
94% identical to CYP2A3
CYP2A17 Cricetulus griseus (Chinese hamster)
No accession number
Kouichi KUROSE
86% identical to CYP2A14
submitted to nomenclature committee 11/29/99
CYP2A18PC human pseudogene
AC008537
Hoffman S.M.G., Nelson, D.R. and Keeney, D.S.
Organization, strtucture and evolution of the CYP2 gene cluster
On human chromosome 19.
Pharmacogenetics 11, 687-698 2001
C-terminal part of P450 only. This is the opposite end of the
pseudogene CYP2A18PN. This gene appears to be split by a 2B6, 2B7P1
insertion.
CYP2A18PN human pseudogene
AC008537
Hoffman S.M.G., Nelson, D.R. and Keeney, D.S.
Organization, strtucture and evolution of the CYP2 gene cluster
On human chromosome 19.
Pharmacogenetics 11, 687-698 2001
N-terminal part of P450 only. This is the opposite end of the
pseudogene CYP2A18PC. This gene appears to be split by a 2B6, 2B7P1
insertion. This name replaces the old designations CYP2A7PT
and CYP2A7PC. There now seems to be only one copy of this pair
in the sequenced human genome.
CYP2A18PN human pseudogene (formerly CYP2A7PT)
GenEMBL U22030(1192bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
There are two human pseudogenes of 2A7 on chromosome 19. They are
Located adjacent to each other. This one is telomeric.
Note added 4/10/2001 This gene appears to be split by a 2B6, 2B7P1
insertion. This name replaces the old designations CYP2A7PT
and CYP2A7PC. There now seems to be only one copy of this pair
in the sequenced human genome.
CYP2A18PN human pseudogene (formerly CYP2A7PC)
GenEMBL U22044(1192bp)
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
There are two human pseudogenes of 2A7 on chromosome 19. They are
Located adjacent to each other. This one is centromeric.
Note added 4/10/2001 This gene appears to be split by a 2B6, 2B7P1
insertion. This name replaces the old designations CYP2A7PT
and CYP2A7PC. There now seems to be only one copy of this pair
in the sequenced human genome.
CYP2A19 Sus scrofa (pig)
GenEMBL AB052255
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
89% to human CYP2A13
clone name c7
Cyp2a20pX mouse
GenEMBL NW_000310 (52646-53186)
53186 MTLS (frameshift) MLLVAVLTCFIAMITMSVLR*KKLLGK
MPPGPTPLPFLGNFLELDTKKFYDSFLRVVLGREM (0) 52988
52810 IREWYGPVFTVHLGTYSAVVPWGYDVVKETLVDQAEQFSGRGEQAFLDWFFKGYG 52646
renamed Cyp2a12-de1b2b
Cyp2a21-ps mouse
GenEMBL NW_000308.1, NW_033707.1, NT_039411.1
93% to Cyp2a5
runs off end NW_000308.1|Mm7_WIFeb01_154 also on
NW_033707.1|MmUn_WIFeb01_40262
t in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
between 2a22 and 2a12
NT_039411.1 + strand seq = 20,879bp runs off end
15607 FFLGKRGIEEHIQEEVGLLIDSFRKTNG 15690
15948 GAFIDTTFYLSRTVSNVISSIIFRDRFDYEDKEFLSLL*MMLGSFQFTATSMGQ 16109
17609 LYEMFSSVMKHLSGPQQQAFKELQGLEDFITKKVEHNQRTLDPNSPRDFIDSFLIRMLE 17785
19308 EKKNPNTEFYMKNLVLTTQNLFFAGTETVSTTLRYGFLLLMKHPDIE 19448
19888 AKVHKEIDWVTGRNWQPKYEDRMKMPYAEAVIHEIQRFADMIPMGLARRVTKDTKFRDFLLPK 20076
20678 GTEVFPMLGSVLKDPKFFFNPKDFNPKHFLDDKGQFKKSDAFVPFSIG 20821
Cyp2a22 mouse
GenEMBL NW_000308.1|Mm7_WIFeb01_154
Also on NT_039411.1 - strand
93% to Cyp2a12
between 2a5 and 2a12
NW_000308.1
MLGSGLLLVAILVFLSVMVLVSVWQQKIRGKLPPGPIPLPFIGNYLQLNRKDVYSSITQ 392
LQEHYGPVFTIHLGPRRVVVLYGYDAVKEALEDNAEEFSGRGEQATFNTLFKGYG 834
VTFSNGERAKQLRRFSIATLKDFGLGKRGMEERIQEEAGCLIKMLQGTC 1495
GAPIDPTMYLSKTVSNVISSIVFGDRFNYEDKEFLSLLQMMSQMNQFAASPTGQ 1874
LYDMFHSVMKYLPGPQQQIIKDSHKLEDFMIQKVKHNHSTLDPNSPRGFIDSFLIHMQK 3263
EKNFNSEFHMKNLVMTSLNLFFAGSETVSSLLRYGFLLLMKHPDVE 4834
AKVHEEIDRVIGRNRQPQYEDHMKMPYTQAVIHEIQR 5365
FSNFAPLGIPRRITKDTSFRGFFLPK 5443
GTDVFPIMGSLMIDPKFFSSPKDFNPQHFLDDKGQLKKIPAFLPFSI 6101
GKRSCLGYSLGKMQLFLFFTTILQNFRFKFPRKLEDINESPKPEGFTRIIP 7191
KYTMSFVPI* 7221
Cyp2a22-de1b2b mouse
GenEMBL NW_011833.1|MmUn_WIFeb01_20427
between 2a22 and 2a5
93% to Cyp2a12-de1b2b
old name = Cyp2a23p
u in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
MLLVAILTCFIAMITMSVLR*RKVLGKIPPGPTPLPFLGNFLELDTKKFYDSFLRV
VLGREM
IRELYGPVFTVHLGTHSAVVPWGYDVVKEALVDQAEQFSGRGEQAFLDWFFKDYG
CYP2A23 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
93% to CYP2A13, 92% to CYP2A6 human, possible ortholog of CYP2A13
CYP2A23 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2A#1_27B2
98% to 2A23 Macaca mulatta 8 aa diffs
note 2A23 and 2A24 are very similar to 2A6 and 2A13, but I
cannot assign orthologs without mapping data.
CYP2A24 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
94% to CYP2A6, 93% to CYP2A13 human, possible ortholog of CYP2A6
CYP2A24 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2A#2_2-G10
98% to 2A24 Macaca mulatta 8 aa diffs
note 2A23 and 2A24 are very similar to 2A6 and 2A13, but I
cannot assign orthologs without mapping data.
CYP2A23/24 Macaca fascicularis (cynomolgus monkey)
PIR S36874 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
Identical to first 13 aa of CYP2A23 or CYP2A24
MLASGLLLVALLA
CYP2A25 Canis familiaris (dog)
XM_541607.2, NM_001048027
87% to CYP2A13 human
There is a second CYP2A in dog that is 91% to CYP2A13
That seq is the probable ortholog of CYP2A13
Dog cluster order 2S(-), 2B(+), 2G(+), 2A25(+), 2A13(-), 2F(+), 2T(+)
Note: this seq is the same as Seq 1 sent by Tom Rushmore
On 6/28/05 except for a short frameshifted region
CYP2A25 Canis familiaris (dog)
NW_876270.1:43197750-43203984
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
88% to human 2A13
MVASGILLVALLTCLTVMVLMSVWRQWKLLEKLPPGPTPLPFIGNYLQLNIQQMSDSFMKISKRYGPVFTIHLGP
RRVVVLCGYEAVKEALVDQAEEFSGRGAQATFDTLFKGYGVTFSNGERAKQLRRFSITTLRDFGVGKRGIEERIQ
EEAGFLIEALRGTRGAFIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQLCEMFHS
VIKYLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMQEEQNNPNTEFHLKNLVLTTLNLFF
AGTETVSTTLRYGFLLLMKHPDVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDIIPLSLARRVI
KDTKFREFLLPKGTEVFPMLGSVLRDAKFFSNPQDFHPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
LFLTTILQNFHFKSPQLPQDIDVSPKLVGLATIPRNYTMSFQPR*
2B Subfamily
CYP2B1 or 2 rat
PIR A92255 (22 amino acids) B92255 (22 amino acids)
Botelho, L.H., Ryan, D.E. and Levin, W.
Amino acid compositions and partial amino acid sequences of
three highly purified forms of liver microsomal cytochrome
P-450 from rats treated with polychlorinated biphenyls,
phenobarbital, or 3-methylcholanthrene.
J. Biol. Chem. 254, 5635-5640 (1979)
CYP2B1 or 2 rat
PIR A60822 (20 amino acids)
Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
Oesch, F.
Effect of nutritional imbalances on cytochrome P-450 isozymes
in rat liver.
Biochem. Pharmacol. 37, 3245-3249 (1988)
CYP2B2 rat
GenEMBL S51970 (2946bp)
Hoffmann,M., Mager,W.H., Scholte,B.J., Civil,A. and Planta,R.J.
Analysis of the promoter of the cytochrome P-450 2B2 gene in the
rat.
Gene Expr. 2, 353-363 (1992)
promoter region, no coding sequence
CYP2B2 rat
GenEMBL L28169 (1401bp)
Shephard,E.E.A.
unpublished (1993)
promoter region
CYP2B2 rat
GenEMBL I00525 (427bp)
White,P.C., Dupont,B. and New,M.I.
Genetic probe used in the detection of adrenal hyperplasia
Patent: US 4720454-A 3 19-JAN-1988
Includes I-helix region
CYP2B3 rat
GenEMBL U16209 to U16214
Jean,A., Reiss,A., Desrochers,M., Dubois,S., Trottier,E., Trottier,Y.,
Wirtanen,L., Adesnik,M., Waxman,D.J. and Anderson,A.
Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and
immunological identification of a constitutive P450 2B3-like protein in
rat liver.
DNA Cell Biol. 13, 781-792 (1994)
CYP2B3-se1[9] rat
exon 9 100% match to 2B3 chr1 (+)frag a in fig below
81263180 GKRMCLGEGIARSELFLFFTTILQNYSVSSPVDPNTIDMTPKESGLAKVAPVYKICFVAR* 81263362
rat, mouse and human 2ABFGST clusters
CYP2B3-se2[1] rat
duplicate exon 1 100% match Chr1 (-)frag b in fig below
81308557 MDTSVLLLLAVLLSFLLFLVRGHAKVHGHLPPGPRPLPLLGNLLQMDRGGFRKSFIQ 81308387
rat, mouse and human 2ABFGST clusters
CYP2B4 rabbit
GenEMBL L10912 (2026bp)
Ryan,R., Grimm,S.W., Kedzie,K.M., Halpert,J.R. and
Philpot,R.M.
Expression and induction of cytochromes P450 2B and P450 4B,
identification of P450 2B-Bx, and functional comparison of four
highly related forms of P450 2B.
unpublished (1993)
CYP2B4 rabbit
GenEMBL S64259 (2028bp) PIR S35666 (491 amino acids)
Ryan,R., Grimm,S.W., Kedzie,K.M., Halpert,J.R. and Philpot,R.M.
Cloning, sequencing, and functional studies of
phenobarbital-inducible forms of cytochrome P450 2B and 4B
expressed in rabbit kidney
Arch. Biochem. Biophys. 304, 454-463 (1993)
CYP2B4 rabbit
Swiss P00177 PIR S31277 (491 amino acids) S31278 (491 amino acids)
PIR S31279 (491 amino acids)
Gasser R., Negishi M., Philpot R.M.
Primary structures of multiple forms of cytochrome P-450 isozyme 2
derived from rabbit pulmonary and hepatic cDNAs.
Mol. Pharmacol. 32, 22-30 (1988)
CYP2B5 rabbit
CYP2B6 human
PIR S04579 (139 amino acids) PIR S04580 (170 amino acids)
Miles, J.S.,Spurr, N.K., Gough, A.C., Jowett,T., McLaren, A.W.,
Brook,J.D. and Wolf, C.R.
A novel human cytochrome P450 gene (P450IIB): chromosomal
localization and evidence for alternative splicing.
Nuc. Acids Res. 16, 5783-5795 (1988)
CYP2B6 human
GenEMBL M29874
Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
cDNA cloning and sequence and cDNA-directed expression of human
P450 IIB1: identification of a normal and two variant cDNAs derived
from the CYP2B locus on chromosome 19 and differential expression
of the IIB mRNAs in human liver.
Biochemistry 28, 7340-7348 (1989)
clone name hIIB1
CYP2B6 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP2B6, probable ortholog of CYP2B6
name changed to reflect orthology formerly CYP2B30
CYP2B6 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2B6
3 aa diffs to CYP2B6 Macaca mulatta
CYP2B6 Macaca fasicularis (cynomolgus monkey)
No accession
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
91% to human 2B6, 90% to human 2B7P1
4 amino acids diffs to Yasuhiro Unos seq
CYP2B6 Bos taurus (cow)
See cattle page for details
MELSMLLLFALLTGLLVLLARGRPKAHGRLPPGPRPLPFLGNLLQMDRKGLLKSFLR
FQQKYGDVFTVYLGPRPVVIICGTEAIREALVDQAEVFSGRAKIAVVDPIFQGY
GVIFANGERWKALRRFSLATMRDFGMGKRSVEERIQDEAQCLVEELRKSQ
GALQDPVFYFHSITANIICSIVFGKRFDYRDPEFLRLLELLFQSFVLISSLSSQ
LFELYSSFLKYFPGSHRQIYKNLQEINVFIGRSVEQHRETLDPNAPRDFIDCYLLRMEKDKSNPQSQFDHQN
LIMSVLSLFFAGTETTSTTLRYGFLLMLKYPHITERIQKEIDQVIGSYR
PALDDRAQMPYTDAVIHEIQRFADLIPIGVPHMVTKDTHFRGYILPK
GTEVYPVLSSALHESCYFEKPDDFNPDHFLDANGVVKKNDAFMPFSI
GKRICLGEGIARIELFLFFTTILQNFSVASPVAPEDIDLTPQESGVGNVPPNYRIQFLPRQRG*
CYP2B7P1 human
GenEMBL M29873
Yamano,S., Nhamburo,P.T., Aoyama,T., Meyer,U.A., Inaba,T.,
Kalow,W., Gelboin,H.V., McBride,O.W. and Gonzalez,F.J.
cDNA cloning and sequence and cDNA-directed expression of human
P450 IIB1: identification of a normal and two variant cDNAs derived
from the CYP2B locus on chromosome 19 and differential expression
of the IIB mRNAs in human liver.
Biochemistry 28, 7340-7348 (1989)
clone name hIIB3
This entry was originally made then discontinued as 2B7PX because an article by
Miles et al. Nuc. Acids res. 18, 189 (1990) showed evidence of alternative splicing
of CYP2B6. I thought that this explained the difference. However, on going back
and looking at the sequences and the EST data and mRNAs, there are clearly two
different genes in the 2B human subfamily. M29873 has an in frame stop codon,
making it a pseudogene.
CYP2B7P Bos taurus (cow)
See cattle page for details
stop codon same as in human 2B7
PALDDRAQMPYTDTVIHEIQRFADLISIGVSHMDAKDAHF*GYILPK
Cyp2b8 rat
Cyp2b9 mouse
GenEMBL M60267 to M60273, also AH000038
Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
Structures and characterization of sex-specific mouse cytochrome
P-450 genes as members within a large family. Duplication boundary
and evolution
Eur. J. Biochem. 195, 477-486 (1991)
Cyp2b9-de9b mouse
GenEMBL XM_145463, XP_145463, NT_039410.1
x in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exon 9 between Cyp2a4 and Cyp2b9
old name = Cyp2b25p
NT_039410.1 - strand
196560 SGTRICLGEGIARSELFLFFTTILQ 196486
196484 NFSVSSPVAPKDIDITLKESGLAKIPPVYKISFLAH* 196374
Cyp2b10 mouse
GenEMBL M21856, PIR A60559 (15 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
Note: the genome of mouse has only one sequence for Cyp2b10 and Cyp2b20. They are derived from the same gene. The Cyp2b10 mRNA M21856 appears to contain errors in the sequence. No exact match for it can be found in the mouse genome.
This mRNA has an extra exon called exon 8b (27 nucleotides in the heme binding peptide region). This appears to be an alternative splice variant of this gene.
The Cyp2b20 sequence matches the genomic sequence and represents the correct 2b10 sequence. The Cyp2b20 name has been discontinued and Cyp2b10 has been retained
since it is the older of the two names.
GenEMBL M21856 (sequence Cyp2b10 was based on)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLLQMDRGGLLKSLIQ
LREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVAVVEPTFKEY
GVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANVICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQ
MFELFSGFLKYFPGAHRQISKNLQELLDYIGHSVERHKATLDPSVPRDFIDIYLLRMEK
EKSNQNAEFHHQNLMMSVLSLFFVGTETSSTTLHYGFLLMLKYPHVTEKVQKEIDQVIGS
HRLPTLDDRTKMPYSDAVIHEIQRFSDLIPIGVPHRVTKDTLFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDQFLDANGALKKSEAFLPFST
Exon 8b GQIFDQKSV
GKRICLGESIARSELFLFFTSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR
GenEMBL AK028103 from RIKEN (corrected Cyp2b10/Cyp2b20 sequence)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR
CYP2B11 Canis familiaris (dog)
NW_876270.1: 43114807-
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
78% to human 2B6
MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFLQMDRKGLLKSFLRLQEKYGDVFTVYLGPRRT
VMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEA
QCLVEELRKTEGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFELFHSFLK
YFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEKAEPSSEFHHRNLIDSALSLFFAGT
ETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDI
CFRGYIIPKGTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFF
TTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSR*
CYP2B12 rat
GenEMBL S48369 X63545 (2528bp) Swiss P33272 (492 amino acids)
PIR S27160 (492 amino acids)
Friedberg,T., Grassow,M.A., Bartlomowicz-Oesch,B., Siegert,P,
Arand,M., Adesnik,M. and Oesch,F.
Sequence of a novel cytochrome CYP2B cDNA coding for a
protein which is expressed in a sebaceous gland, but not in the liver.
Biochem. J. 287, 775-783 (1992)
CYP2B12-de9b rat
exon 9 Chr1 (-) frag c in fig. below
81829155 GKFICLGEGIG*NESFIFFTGILQNLSLASPVAPENIDLTPIKSGAGKIPSTYQIHILSR 81829012
rat, mouse and human 2ABFGST clusters
Cyp2b13 mouse
GenEMBL M60352 to M60358, also AH000037, NT_039410.1
Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
Structures and characterization of sex-specific mouse cytochrome
P-450 genes as members within a large family. Duplication boundary
and evolution.
Eur. J. Biochem. 195, 477-486 (1991)
Cyp2b13-de1b2b7b mouse
GenEMBL NT_039410.1 + strand
y in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exons 1,2,7 between Cyp2b13 and Cyp2b26-ps
43894 XXXXXXDIFYMGAQPLLVLCGYEV*WEAPVDHSEVFLVYEDKAIIDPSSKKW 44031 ex 1
44377 XXFFVNGKPWNIVN*FLLTTTKDFEWKKRSIDNQIKVETLDLLLEC*KPHGDP 44529 ex 2
48130 LPVFVHWAQKPYTQASIHEIWRYGDFTHIG 48219 ex 7
CYP2B14X rat
discontinued number see CYP2B16P
CYP2B14P rat
GenEMBL U33540
Eric Trottier, Stéphane Dubois, Andréa Jean and Alan
Anderson
Identification of CYP2B14P and CYP2B16P, two apparent pseudogenes in
the rat cytochrome P450 2B (CYP2B) subfamily.
Biochemical Pharmacology, 52, 963-965 (1996)
exon 1, add Chr1 (+) exons 7,8,9 72% to 2B21 to this pesudogene
81706300 MKPNVLLLLAILLSFLLFLVRGHAKVHGHLPPGPRPLPILGNLLQMDRGGLLQSF 81706464
81728276 EKVQKEIGEVTGSHWFPILYSSKIPNTEAVIPEIQR 81728383
81728385 FSDLSSVVLPQRVTKDTFFQGFLLHK 81728462
81728634 NTEVYPILSSVLHDPQ 81728681
81728681 VLEYPVTFNPEHFLDANGALKKNEAFTPFSR 81728773
CYP2B15 rat
GenEMBL D17343 to D17349
Nakayama,K., Suwa,Y., Mizukami,Y., Sogawa,K. and Fujii-
Kuriyama, Y.
Cloning and sequencing of a novel rat cytochrome P450 2B-encoding
gene.
Gene 136, 333-336 (1993)
most similar to 2B12, 89% identical
MELGVLLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQLQ
EKYGDVFTVHLGPRPVVILCGTDTIREALVDQAEAFSGRGTVAVLHPVVQGYGVIFANGE
RWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYKALLNPTSIFQSIAANIIC
SIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQVFELFSGFLKYFPGVHKQISKNLQE
ILNYIDHSVEKHRATLDPNTPRDFINTYLLRMEKEKSNHHTEFHHQNLVISVLSLFFTGT
ETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFA
DLIPIGLPHRVTNDTMFLGYLLPKNTEVYPILSSALHDPRYFDHPDTFNPEHFLDVNGTL
KKSEAFLPFSTGKRICLGEGIAQNELFIFFTAILQNFSLASPVAPEDIDLSPINSGISKI
PSPYQIHFLSRCVG
CYP2B16P rat
GenEMBL U33541 to U33546
Eric Trottier, Stéphane Dubois, Andréa Jean and Alan Anderson
Identification of CYP2B14P and CYP2B16P, two apparent pseudogenes in the rat
cytochrome P450 2B (CYP2B) subfamily.
Biochemical Pharmacology, 52, 963-965 (1996)
note: previously called CYP2B14 in 1993 update. This gene has a complete
coding sequence but there is a defect in the splice junction in intron 1.
Exon 1 MEPSVLLLLAVLLSFLLLLVRGHAKIHGRLPPGPCPVPLLGNLLQMDRRGLLKSFIQLR
Exon 2 EKYGDVFTVHLGLRPVVVLCGTQTIREALVDHAEAFSGRGTIAGLEPVFQDYG
Exon 3 IFFSSGEQWKTLRRFSMATMRDFGMRKKSVEERIKEESQCLVEELKKYQG
Exon 4 APLDPTFLFQCITSNIICSIVFGECFDYTDHQFLHLLDLMYQTFSLLSSIFSQ
Exon 5 VFELFPGVLKYFPGAHRQISRNLHEILDFIGQSVEKHRATLDPNAPRDFIYTYLLHMEK
Exon 6 QKSNHYTEFHHWNLLSSVLSLFFAGTETSSTTLRYGFLIMLKYPHI
Exon 7 EKVQKEIDCVIGSHRLPTLDDRSKMPYTEAVIHEIQRFSDLAPIGTPHRVIKDTIFRGYLLPK
Exon 8 QNTEVFPILSSVLHDPQYFEQPDIFNLQHFLDANGALKIIEAFLPFSTGK
Exon 9 TGKRICLGESIARNELFLFFTTILQNFSVSSPVAPKDIDLTPKESGIGRIPQVYQICFLA
CYP2B17/2B6 Cercopithecus aethiops (African green monkey)
PIR JT0676 (491 amino acids)
Ohmori, S.; Sakamoto, Y.; Nakasa, H.; Horie, T.; Saito, K.; Kitada, M.
Nucleotide and amino acid sequences of monkey P450 2B gene
subfamily.
Unpublished
91% to human 2B6 probable ortholog
CYP2B18 guinea pig
no accession number (437 amino acids)
Oguri, K.
submitted to nomenclature committee
Cyp2b19 mouse
GenEMBL AF047529, also NT_039410.1 + strand
Diane Keeney, D.S. (1998) The Novel Skin-Specific Cytochrome P450
Cyp2b19 Maps to Proximal Chromosome 7 in the Mouse, near a Cluster of
Cyp2 Family Genes.
Genomics 53, 417-419.
Between 2b23 and 2g1
Cyp2b19-de7b8b9b mouse
GenEMBL NT_039410.1
old name = Cyp2b24p
v in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exons 7,8,9 between 2b19 and 2b23
NT_039410.1 + strand
695673 EKVQKETDQVIGSHQLPTLDDRTKMPYTDTVIHEIQRFSDLAAIDLPHRVTIHTLSQVYLLPK 695861
696036 NTEVYPILSSVLLDP 696080
696083 QYFEQLDCFNPEHFLDANGTLKKSEAFLPFST 696178
702801 GKHVCLGKGIAHNELFLFFPTILQNFPVSVPLAPKDIDITPKESGTGKIPQCTRSAS 702971
Cyp2b20X mouse
GenEMBL X99715(1416bp)
Damon,M., Fautrel,A., Marc,N., Guillouzo,A. and Corcos,L.
Isolation of a new mouse cDNA clone: hybrid form of cytochrome P450
2b10 and NADPH-cytochrome P450 oxidoreductase
Biochem. Biophys. Res. Commun. 226 (3), 900-905 (1996)
This clone has a part of the NADPH cytochrome P450 reductase on the
opposite strand at the end of the P450 sequence.
note: this sequence was accidentally given the name Cyp2b19. That
name is assigned to a mouse keratinocyte P450 cloned by Diane Keeney.
The reductase sequence at the end of this gene seems to be a cloning
error, because it cannot be found in the genomic DNA sequence.
Cyp2b20 has been merged with Cyp2b10. Though the Cyp2b20 sequence
is more like the genomic sequence, the Cyp2b10 name has precedence.
GenEMBL AF128849
Marc,N., Damon,M., Fautrel,A., Guillouzo,A. and Corcos,L.
Isolation of a cyp2b10-like cDNA and of a clone derived from a
cyp2b10-like pseudogene
Biochem. Biophys. Res. Commun. 258 (1), 11-16 (1999)
This sequence is 100% identical to Cyp2b20 and 97% identical to
Cyp2b10
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR
Cyp2b20X mouse
GenEMBL AK028103 100% identical to AF128849
Now renamed Cyp2b10 (the corrected sequence)
MEPSVLLLLALLVGFLLLLARGHPKSRGNFPPGPRPLPLLGNLL
QMDRGGLLKSFIQLREKYGDVFTVHLGPRPVVMLCGTDTIREALVGQAEAFSGRGTVA
VVEPTFKEYGVIFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKS
QGAPLDPTFLFQCITANIICSIVFGERFEYTDRQFLRLLELFYQTFSLISSFSSQMFE
LFSGFLKYFPGAHRQISKNLQELLDYIGHSVEKHRATLDPSVPRDFIDIYLLRMEKEK
SNQHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGS
HRLPTLDDRTKMPYTDAVIHEIQRFSDLIPIGVPHRVTKDTMFRGYLLPKNTEVYPIL
SSALHDPQYFEQPDSFNPDHFLDANGALKKSEAFLPFSTGKRICLGESIARNELFLFF
TSILQNFSVASHVAPKDIDLTPKESGIGKIPPTYQICFLAR
Cyp2b20p1X mouse
GenEMBL AF129405
Marc,N., Damon,M., Fautrel,A., Guillouzo,A. and Corcos,L.
Isolation of a cyp2b10-like cDNA and of a clone derived from a
cyp2b10-like pseudogene
Biochem. Biophys. Res. Commun. 258 (1), 11-16 (1999)
This sequence is 100% identical to Cyp2b20 from amino acid 64 on
This seq is partial, starting at amino acid 60 with a stop codon
at amino acid 63. Full length cDNAs AK028103 and AF128849 do not
have this stop codon and it is not found in genomic DNA.
This probably represents a sequence derived from the Cyp2b10 gene.
CYP2B21 rat
GenEMBL AF159245
Nicola Brookman Amissah and Peter Swann
CYP2B22 Sus scrofa (pig)
GenEMBL AB052256
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
78% to rabbit CYP2B4
clone name c780
Cyp2b23 mouse
NW_000307 618973-640139, also XM_145466
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Next to Cyp2b19-de7b8b9b and 2b19 on chr 7
Cyp2b24pX mouse
NW_000307 692575-699876
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Next to 2b19 on chr 7
Renamed Cyp2b19-de7b8b9b
Cyp2b25pX mouse
NW_000307 195792-195980
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Next to 2b9 on chr 7
Renamed Cyp2b9-de9b
Cyp2b26-ps mouse
GenEMBL AC087157 22100-26200
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Between 2b9 and 2b13 on chr 7
Cyp2b27-ps mouse
NW_000303 2122792-2130037
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Between 2b13 and 2b28-ps on chr 7
Cyp2b28-ps mouse
NW_000303 2064442-2094900
Haoyi Wang, Kyle Donley, Diane Keeney, Susan Hoffman
Between 2b27-ps and 2b10 on chr 7
CYP2B29 hamster
No accession number
Pedro Dominguez
Submitted to nomenclature committee Dec. 17, 2002
77% to cyp2b10
CYP2B30X Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP2B6, probable ortholog of CYP2B6
name changed to reflect orthology = CYP2B6
CYP2B31 rat
86% to 2b19 possible ortholog
81918041 MELGVFLLLTFTVGFLLLLASQNRPKTHGHLPPGPRPLPFLGNLLQMNRRGLLRSFMQ 81918214
81919826 LQEKYGDVFTVHLGPRPVVILCGTDTMREALVDQAEAFSGRGTVAVLHPVVQGY 81919987
81920130 GVIFANGERWKILRRFSLVTMRNFGMGKRSVEERIKEEAQCLVEELKKYK 81920279
81922129 GALLNPTSIFQSIAANIICSIVFGERFDYKDHQFLRLLDLIYQTFSLMGSLSSQ 81922290
81923031 VFELFSGFLKYFPGVHKQISKNLQEILNYIDHSVEKHRATLDPNTPRDFIDTYLLHMEK 81923207
81923977 EKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVA 81924117
81926113 EKVQKEIDQVISSHRLPTLDDRIKMPYTDAVIHEIQRFADLAPIGLPHRVTKDTMFRGYLLPK 81926301
81926476 NTEVYPILSSALHDPRYFDHPDTFNPEHFLDANGTLKKSEAFLPFST 81926616
81930286 GKRTCLGEGIARNELFIFFTALLQNFSLASPVAPEDIDLTPINSGAGKIPSPYQINFLSR 81930465
CYP2B32P rat
pseudogene partial Chr1 (+)
81806528 VLLLLTLIVGFLLFLVSQSQPKTHGHLPPGLCPLPFLGNLLQIKRRGLLNSFMQ 81806689
81808348 AQEKYGDVLTVHPGPRPVVRLCGTDTIREFLFDQAGTFSGQGTVAVLNPVVHGY 81808509
exon 3 missing
81809871 GVPLIPTSFFQRIAANIICSIVFGECFDYKDHQFLHLLDLIYQTFALMAPCPARS 81810035
81810759 VFQLFSGFLKYFPGVHKQISKNLQEILNYIGHSVEKHMATLDPSAPRDFINTYLLHMEN 81810935
81811666 EKSNHHTEFHHQTSVLSHFFDGTETTSTTLCCSFLIMLKYHHVK 81811797
CYP2B guinea pig
Swiss P34033 (20 amino acids)
Narimatsu S., Akutsu Y., Matsunaga T., Watanabe K., Yamamoto I.,
Yoshimura H.
Purification of a cytochrome P450 isozyme belonging to a subfamily of
P450IIB from liver microsomes of guinea pigs.
Biochem. Biophys. Res. Commun. 172, 607-613 (1990)
PIR S28205 (31 amino acids)
Yamada, H., Kaneko, H., Takeuchi, K., Oguri, K. and Yoshimura,H.
Tissue-specific expression, induction, and inhibition through
metabolic intermediate-complex formation of guinea pig
cytochrome P450 belonging to the CYP2B subfamily.
Arch. Biochem. Biophys. 299, 248-254 (1992)
Note: These two fragments are identical over the first 20 amino acids.
Cyp2b mouse
PIR A21630 (25 amino acids)
Stupans, I., Ikeda, T., Kessler, D.J. and Nebert, D.W.
Characterization of a cDNA clone for mouse
phenobarbital-inducible cytochrome p-450b.
DNA 3, 129-137 (1984)
This fragment has one amino acid difference with 2b-9, 2b-10 and 2b-13
Cyp2b mouse
GenEMBL M60359 (997bp)
Lakso,M., Masaki,R., Noshiro,M. and Negishi,M.
Structures and characterization of sex-specific mouse cytochrome
P-450 genes as members within a large family. Duplication boundary
and evolution.
Eur. J. Biochem. 195, 477-486 (1991)
N-terminal 57 amino acid fragment very similar to Cyp2b-13.
CYP2b scup (fish Stenotomus chrysops)
N-terminal fragment (20 amino acids)
Klotz et al. Arch. Biochem. Biophys. 249, 326-338 (1986)
2C Subfamily
CYP2C1 rabbit
GenEMBL D26152 (1695bp)
Noshiro,M., Ishida, H. and Okuda, K.
unpublished (1993)
CYP2C2 rabbit
CYP2C3 rabbit
CYP2C4 rabbit
CYP2C5 rabbit
GenEMBL M55664 (2340bp)
Pendurthi,U.R., Lamb,J.G., Nguyen,N., Johnson,E.F. and Tukey,R.H.
Characterization of the CYP2C5 gene in 21L III/J rabbits: Allelic
variations affects the expression of P450IIC5
J. Biol. Chem. 265, 14662-14668 (1990)
CYP2C5 rabbit
PIR S16715 (143 amino acids) PIR S20227 (145 amino acids)
Zhao, J., Leighton, J.K. and Kemper, B.
Characterization of rabbit cytochrome P450IIC4 cDNA and
induction by phenobarbital of related hepatic mRNA levels.
Biochem. Biophys. Res. Commun. 146, 224-231 (1987)
CYP2C6 rat
PIR A41425 (17 amino acids)
Imaoka, S., Kamataki, T. and Funae, Y.
Purification and characterization of six cytochromes P-450
from hepatic microsomes of immature female rats.
J. Biochem. 102, 843-851 (1987)
rat 2C cluster in chromosome order
CYP2C6v1_v1-de1b2b3b4b5b rat
upstream pseudogene frag o, 96% identical to seq c
93% identical to seq upstream of CYP2C6v2 allele (temp name = CYP2Cnewb)
243935799 MDLVMLLVLTLSCLIFLSIWRQSSGRGKLP 243935888
243935888 SGPTPLPIIGNFFHLDLKNITQSLTN 243935965
243937699 FSKVNGSVFTLYFGMKPIVILHGYEAIKEGLIDHGEEFTERGSFPVAEKINKGL 243937860
243938035 GIAFSHGNRWKEIRRFTLMTLQNLGMGKKSIEDRVQEESRCLV 243938163
243939079 GSPCDPTFILGCAPCNVICSIIFQNCFDYKDQDFLSLVEKLNENIKIVSSPWI* 243939231
243940291 FCSSFPVFIDYCPGSHMTLAKNVYHTRNYILKKIKEHQESLDVTNPHDFIDYYLINWKQ 243940467
CYP2C6v1_v1 rat
GenEMBL M13711
two aa changes to match many ESTs (lower case mi)
due to frameshift 97% to 2C77 and 2C6v2
243955584 MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTS 243955751
243964779 FSKVYGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKD 243964937
243965112 LGIVFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTN 243965264
243966104 GSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQ 243966265
243967336 FCSFFPVLIDYCPGSHTTLAKNVYHIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQ 243967512
243984646 ENHNPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKCPEVT 243984786
243989157 AKVQEEIDRVVGKHRSPCMQDRSRMPYTDAmiHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPK 243989345
243990948 GTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSA 243991088
243992245 GKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL 243992424
CYP2C6v2-de1b2b3b4b4c5b rat
upstream pseudogene
EST CK224599.1 = 100% match with 4 frameshifts) so this is a real gene
clone_lib="RALIUNN03 Sprague-Dawley rat female liver
The CYP2C6_v1 sequence is also seen in this same mRNA library
This GNOMON prediction adds two upstream exons that do not belong to this gene
58596732 MDLVMLLVLTLSCLILLSIWRQSSGRGKHP 58596643 exon 1 frameshift
58596643 SGPTPLPIIGNFFHLDLNNITQSLTS (0) 58596566 exon 1
58594823 FSKVNGSVFTLYFGMKLIVILHGYAATKEGLIDHGEEFTKRGSFPVAEKINKGL (1) exon 2 58594662
58594487 GIAFSHGNRWKEIRRFTLMTLQNLGMGKESIEDRVQEETQCLV*ELRKTN (1) exon 3 58594338
58593451 GSPCDPTFILGCAPCNVICSIIFQNCFDYKDQDFLSLMEKLNENIKIVSSPW 58593296
58592013 GSPCDPTFILGCAPCNVICSIIFQNCFDYKDQDFLSLMEKLNENIKIVSSPW 58591858
58590797 FCSSFPVFIDYCLGSHMTLA 58590738
58590736 NVYHTRNYILKKIKEHQESLDVTNPHDFIDYDLIKWKQ 58590620
CYP2C6v2 rat
allele not in figure, 13 aa diffs to CYP2C6_v1 XM_215255 NW_047916
we are assigning this allele status but it may be a separate gene
(temp name = CYP2Cnewb)
58578624 MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTS (0) 58578457
58576741 FSKVYGPVFTLYFGLKPTVILHGYEAVKEALIDHGEEFAERGSFPVVEKINKDL (1) 58576583
58576405 GIAFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDHVQEEARCLVEELRKTN 58576256
58575415 GSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKVLSSPWTQ 58575254
58574189 FCSFFPVLIDYCPGSHTTLAKNIYYIRNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQ 58574013
58554666 ESHNPHLEFTLENLSVTVTDLFGAGTETTSTTLRYALLLLLKYPEVT 58554526
58534931 AKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPK 58534743
58533131 GTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSA 58532991
58531833 GKRMCAGEGLARMELFLFLTTILQNFKLKSVLQPKDIDTTPVFHGFASLPPFYELCFIPL 58531654
CYP2C6P rat
GenEMBL M18336 J03509 M18774
an alternate splice version of 2C6
exon 8 is skipped and replaced by a cryptic exon just past the true exon 8
The GT boundary of the true exon 8 are the first two nucleotides of CYP2C6_v3
Cryptic exon 8
MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTSFSKV 200
201 YGPVFTLYFGTKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDLGIVFSHGNRW 380
381 KEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVICS 560
561 IIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQFCSFFPVLIDYCPGSHTTLAKNVYHI 740
741 RNYLLKKIKEHQESLDVTNPRDFIDYYLIKWKQENHNPHSEFTLENLSITVTDLFGAGTE 920
921 TTSTTLRYALLLLLKCPEVTAKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFID 1100
1101 LIPTNLPHAVTCDIKFRNYLIPK 1169
CYP2C6_v2 CK224594.1 CK224593.1 note: the _v2 means alternative splice version 2
CYP2C6_v3 CK224595.1 CK224596.1 (3 nuc shorter at the joint uses the second AG)
Beginning of exon 7 AGCTAAAG TCCAGGAAGA GATTGATCGT 243989183
GTGGTTGGCA AACATCGCAG CCCTTGCATG CAGGACAGGA GCCGCATGCC CTACACAGAT 243989243
GCCATGATTC ATGAGGTCCA GAGGTTCATT GACCTCATTC CTACCAACCT GCCACATGCG 243989303
GTGACCTGTG ACATTAAGTT CAGGAACTAC CTAATACCCA AG GT end of exon 7
Beginning of cryptic exon out of frame agcaggtaa tagaaactca 243991103
tttccatggt tccagtgaca tgcagaaccg tggggactta gagtgtgact ctacatgtgc 243991163
tgatagcttg catctgcatg ataaggagca taattttcat tgtgtatgca ctgtcctgga 243991223
tatgaccacc ttctttatca gggt end of cryptic exon
normal exon 9
1328 GKRMCAGEGLARMELFLFLTTILQNFKLKSVLHPKDIDTTPVFNGFASLPPFYELCFIPL
rat 2C cluster in chromosome order
see this link for color coded figure of intron boundaries
>interval between 2C6 and 2C77
CYP2C6-se1[1:2:3:2:3] rat
frag n exons 1,2,3 2C6 like pseudogene plus strand exon 2,3 100% to seq m
244044941 MDHTTGTYTLSLILLSL*RQSSGRGKIPPGPTPLPIIDNLLQLDIKNVTQYLAN (0) 244045102
244050420 LSKVHGPVLTLYFWMKSNVVLHVDEAVNEDLIDHGE*FAVRRSIPLAEKLIKAL 244050581
244050793 XXXXXXXXXXXXXKTFTLMTLQNLRMGKGNIEDHVQE*AQ 244050873
frag m Exons 2,3 2C6 like pseudogene 100% to seq n
244052306 LSKVHGPVLTLYFWMKSNVVLHVDEAVNEDLIDHGE*FAVRRSIPLAEKLIKAL 244052467
244052679 XXXXXXXXXXXXXKTFTLMTLQNLRMGKGNIEDHVQE*AQ 244052759
CYP2C7 rat
GenEMBL X12595 (1179bp)
Stroem,A., Nilsson,A.G. and Zaphiropoulos,P.
5' flanking sequence of the gene for rat cytochrome p-450f
Nucleic Acids Res. 0, 0-0 (1988)
rat 2C cluster in chromosome order
CYP2C7 rat
PIR S24582 (66 amino acids)
Stroem, A.
unpublished
rat 2C cluster in chromosome order
CYP2C7 rat
PIR A60563 (56 amino acids)
Westin, S., Stroem, A., Gustafsson, J.A., and Zaphiropoulos, P.G.
Growth hormone regulation of the cytochrome P-450IIC
subfamily in the rat: inductive, repressive, and
transcriptional effects on P-450f (IIC7) and P-450-PB1
(IIC6) gene expression.
Mol. Pharmacol. 38, 192-197 (1990)
rat 2C cluster in chromosome order
CYP2C7 rat
PIR A27425 (23 amino acids)
Favreau, L.V., Malchoff, D.M., Mole, J.E. and Schenkman, J.B.
Responses to insulin by two forms of rat hepatic microsomal
cytochrome P-450 that undergo major (RLM6) and minor
(RLM5b) elevations in diabetes.
J. Biol. Chem. 262, 14319-14326 (1987)
rat 2C cluster in chromosome order
CYP2C7 rat
GenEMBL M18335
exons 1,2,3 and 6 are in sequence gaps 93% to 2C7 variant and 2C81
MDLVTFLVLTLSSLILLSLWRQSSRRRKLPPGPTPLPIIGNFLQIDVKNISQSLTK
FSKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMNENVTKGF
GIVFSNGNRWKEMRRFTIMNFRNLGIGKRNIEDRVQEEAQCLVEELRKTK
243849546 GSPCDPSLILNCAPCNVICSITFQNYFDYKDKEMLTFMEKVNENLKIMSSPWMQ 243849385
243847566 VCNSFPSLIDYFPGTHHKIAKNINYMKSYLLKKIEEHQESLDVTNPRDFVDYYLIKQKQ 243847390
243829444 GSPCDPSLILNCAPCNVICSITFQNHFDYKDKEMLTFMEKVNENLKIMSSPWMQ 243829283
this duplicate exon 4 is not in the right sequence order
ANNIEQSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKYPHVT
243803857 AKVQEEIDRVIGRHRSPCMQDRKHMPYTDAMIHEVQRFINFVPTNLPHAVTCDIKFRNYLIPK 243803669
243800623 GTKVLTSLTSVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFLPFSA 243800483
243799465 GKRACVGEGLARMQLFLFLTTILQNFNLKSLVHPKDIDTMPVLNGFASLPPTYQLCFIPS 243799286
CYP2C7-de7b rat
frag r Exon 7 (+) 100% to seq a CYP2C81-de7b
243792966 RVQEEIDQVIGRNPSPCMQDRSHMPYTNAMVHEVQR*SNIVPNNIVYEVTCDTKFRNYFIPK 243793151
CYP2C7 rat
variant unmapped 93% to 2C7 88% to 2C81
3463873 MDLVTFLVLTLSSLILLSLWRQSSRRRKLPPGPTPLPIIGNFLQIDVKNISQSLTK 3464040
3479907 FSKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMIENVTKGF 3480068
3480234 GIVFSNGNRWKEMRRFTIMTFRNLGIGKRNIEDRVQEEAQCLVEELRKTK 3480383
3489182 GSPCDPSLILNCAPCNVICSITFQSHFDYKDKEMLTFMEKVNENLKIMSSPWMQ 3489343
3491162 VCNSFPSLVDYFPGTHHKIAKNINYMKSYLLKKIEEHQESLDVTNPRDFVDYYLIKQKQ 3491338
3505354 ANNIEQSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKYPHVT 3505494
3406504 AKVQEEIDRVVGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPK 3406692
3408304 GTTIITSLSSVLHDSKEFPDPEIFDPGHFLDGNGKFKKSDYFMPFSA 3408444
3409602 GKRMCAGEGLARMELFLFLTTILQNFKLKSVLQPKDIDTTPVFPGFASLPPFYELCFIPS 3409778
CYP2C7-se1[6:7:9] rat
frag j exons 6,7,9 (6,7 and 9 have 1 aa diff to 2C7)
244103321 ANNIEQSEYSHENLTCSIMDLIGAGTETMSTTLRYALLLLMKYPHVT 244103461
244120225 AKVQEEIDRVIGRHRSPCMQDRKHMPYTDAMIHEVQRFIDFVPTNLPHAVTCDIKFRNYLIPK 244120413
244124319 FLXXXLQNFNLKSLXHPKDIDTMPVLNXXASLPPTYQLCFIPS 244124447
CYP2C7-se2[2:3] rat
frag k exons 2,3 = 100% to 2C7 variant, 2 aa diffs to 2C7 exons 2,3
244064158 FSKTYGPVFTLYLGSQPTVILHGYEAIKEALIDNGEKFSGRGSYPMIENVTKGF 244064319
244064485 GIVFSNGNRWKEMRRFTIMTFRNLGIGKRNIEDRVQEEAQCLVEELRKTK 244064634
CYP2C7-se3[8] rat
frag t Exon 8 minus strand 82% to 2C7
243749788 TIVIT*LTSVLHDSKKFPNPEMLDSGHFLDENGNFKKSEYFMPFSA 243749651
CYP2C7-se4[8:9] rat
frag u Exon 8 minus strand exon 8 = 87% to frag 2, 8+9 = 63% to 2C7
243726168 GVMVITSLSSALHDNKEFPNPKRFDPG*FLDRNGNFKKTDYFILFSA 243726028
Exon 9 minus strand 60% to 2C7
243723025 CVGEGLTPIELFLFLTRILQNFNLKHLTHTEAVDTTPVLSRLTSVSPALKLFFIP 243722861
CYP2C8 human
PIR S15075 (56 amino acids)
Ged, C. and Beaune, P.
Isolation of the human cytochrome P-450 IIC8 gene: multiple
glucocorticoid responsive elements in the 5' region.
Biochim. Biophys. Acta 1088, 433-435 (1991)
CYP2C8 human
GenEMBL Y00498 (1866bp)
Kimura,S., Pastewka,J., Gelboin,H.V. and Gonzalez,J.
cDNA and amino acid sequences of two members of the human P450IIC
gene subfamily
Nucleic Acids Res. 15, 10053-10054 (1987)
CYP2C8 human
PIR S16902 (349 amino acids)
Shephard, E.A., Phillips, I.R., Santisteban, I., Palmer,
C.N.A. and Povey, S.
Cloning, expression and chromosomal localization of a member
of the human cytochrome P450IIC gene sub-family.
Ann. Hum. Genet. 53, 23-31 (1989)
CYP2C8 human
no accession number
D.C. Zeldin, R.N. Dubois, J.R. Falck, and J.H. Capdevila.
Molecular Cloning, Expression, and Characterization of an Endogenous Human
Cytochrome P450 Arachidonic Acid Epoxygenase Isoform.
Arch. Biochem. Biophys. 322: 76-86 (1995)
CYP2C8-de6b human
GenEMBL NT_008769.11|Hs10_8926
detritus exon 6 between 2C9 and 2C8
old name CYP2C60P
8439669 EKDNQPLKFTIENLVGNVPDLFVAGTEMTSTTLRYGLLLLLKHPELT 8439809
CYP2C8 Cercopithecus aethiops (African green monkey)
DQ022200.1
Booth-Genthe,C.L., Peteraf,S. and Tang,C.
Merck Research laboratories
92% to human CYP2C8, 78% to human CYP2C19
CYP2C8/2C20 Macaca fasicularis (cynomolgus monkey)
GenEMBL S53046 (1901bp) Swiss P33262 (490 amino acids)
PIR S28166 (490 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
Note: As comparisons between primates begin to involve large
scale sequencing, the CYP2C20 genes assigned earlier
to two Macaca species appear to be orthologous to human CYP2C8.
I have acknowledged this by using the 2C8 name.
Since both names will be in the literature, both will be
kept, but 2C8 is now the preferred name.
CYP2C8/2C20 Macaca fasicularis (cynomolgus monkey)
PIR A60466 (22 amino acids)
Ohi, H., Toratani, S., Komori, M., Miura, T., Kitada, M. and
Kamataki, T.
Comparative study of cytochrome P-450 in liver microsomes. A
form of monkey cytochrome P-450, P-450-MK1,
immunochemically cross-reactive with antibodies to rat
P-450-male.
Biochem. Pharmacol. 38, 361-365 (1989)
Note: As comparisons between primates begin to involve large
scale sequencing, the CYP2C20 genes assigned earlier
to two Macaca species appear to be orthologous to human CYP2C8.
I have acknowledged this by using the 2C8 name.
Since both names will be in the literature, both will be
kept, but 2C8 is now the preferred name.
CYP2C8/2C20 Macaca mulatta (rhesus monkey) name change from CYP2C74
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP2C8, 78% to CYP2C19, probable ortholog of CYP2C8
formerly CYP2C74. There are only 3 amino acid differences to
Macaca fasicularis (cynomolgus monkey) GenEMBL S53046
Since this is the clear ortholog of that earlier sequence
the name has been changed to reflect the orthology.
Note: As comparisons between primates begin to involve large
scale sequencing, the CYP2C20 genes assigned earlier
to two Macaca species appear to be orthologous to human CYP2C8.
I have acknowledged this by using the 2C8 name.
Since both names will be in the literature, both will be
kept, but 2C8 is now the preferred name.
CYP2C8 Callithrix jacchus (white-tufted-ear marmoset)
GenEMBL AB242600, release date 2006-11-19
Narimatsu, S., Torigoe, F.,Hanioka, N. and Miyata, A.
88% to 2C8 of Cercopithecus aethiops, 87% to 2C8 human
78% to 2C9 human, 77% to 2C18, 77% to 2C19
CYP2C9 human
GenEMBL S46963 (1814bp) PIR A48390 (477 amino acids)
B48390 (475 amino acids)
Ohgiya,S., Komori,M., Ohi,H., Shiramatsu,K., Shinriki,N. and
Kamataki,T.
Six-base deletion occurring in messages of human cytochrome P-450
in the CYP2C subfamily results in reduction of tolbutamide
hydroxylase activity.
Biochem. Int. 27, 1073-1081 (1992)
CYP2C9 human
GenEMBL L16877 to L16883
Goldstein,J.A., Raucy,J.L., Blaisdell,J.A., Faletto,M.B.
and Romkes,M.
Cloning and expression of complementary DNAs for multiple
members of the human cytochrome P450IIC subfamily.
Biochemistry 30, 3247-3255 (1991)
de Morais,S.M., Schweikl,H., Blaisdell,J.A. and Goldstein,J.A.
Gene structure and upstream regulatory regions of human
CYP2C9 and CYP2C18.
Biochem. Biophys. Res. Commun. 194, 194-201 (1993)
CYP2C9 human
PIR B61265 (225 amino acids)
Srivastava, P.K., Yun, C.H., Beaune, P.H., Ged, C. and
Guengerich, F.P.
Separation of human liver microsomal tolbutamide hydroxylase
and (S)-mephenytoin 4'-hydroxylase cytochrome P-450
enzymes.
Mol. Pharmacol. 40, 69-79 (1991)
2C10 has D at position 417 while 2C9 has G. This sequence does not
include position 417. The only other amino acid difference between 2C9
and 2C10 is at position 358 where 2C9 has Y and 2C10 has C. This
sequence has Y at 358.
CYP2C9 human
PIR S26634 (29 amino acids) PIR S23777 (25 amino acids)
Shimada, T., Misono, K.S. and Guengerich, F.P.
Human liver microsomal cytochrome P-450 mephenytoin
4-hydroxylase, a prototype of genetic polymorphism in
oxidative drug metabolism.
J. Biol. Chem. 261, 909-921 (1986)
CYP2C9 human
PIR S39377 (20 amino acids)
Sandhu, P., Baba, T. and Guengerich, F.P.
Expression of modified cytochrome P450 2C10 (2C9) in
Escherichia coli, purification, and reconstitution of
catalytic activity.
Arch. Biochem. Biophys. 306, 443-450 (1993)
CYP2C9-de1b human
GenEMBL NT_008769.11|Hs10_8926
same as AL133513.12, might work for alt splice
detritus exon 1 32kb upstream of 2C9
8335895 MDPAVALVLCLSCLFLLSLWRQSSGRGRLLFGPTPLLIIGNILQLDVKDMSKSLTNVSMLYAPL 8336086
CYP2C9-de2c3c human
GenEMBL NT_008769.11|Hs10_8926
detritus exons 2,3 between 2C9 and 2C8
old name CYP2C59P
8437561 LSQFSKVYVPVFTVYFDIKLVLELHGYEVVKEALIDHGEEFSGKGIFPVSKKS**G 8437394
8437211 FRIIFSNGKRCKDIWLFLLMTLWNCRMVKRS 8437119
8437115 MEKHVQGEAQCLRQELRRTK 8437058
CYP2C9 Macaca fasicularis (cynomolgus monkey)
No accession
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
93% to human 2C9, 91% to 2C19, 81% to 2C18, 76% to 2C8
CYP2C10X human
PIR A61265 (79 amino acids)
Srivastava, P.K., Yun, C.H., Beaune, P.H., Ged, C. and
Guengerich, F.P.
Separation of human liver microsomal tolbutamide hydroxylase
and (S)-mephenytoin 4'-hydroxylase cytochrome P-450
enzymes.
Mol. Pharmacol. 40, 69-79 (1991)
2C10 has D at position 417 while 2C9 has G. This sequence shows the D at
position 417. The only other amino acid difference between 2C9 and 2C10
is at position 358 where 2C9 has Y and 2C10 has C. This sequence does
not include the 358 region.
The 2C10 gene is in some doubt. Others have searched 100 samples looking for it
and have not found it. This gene may not exist.
CYP2C11 rat
GenEMBL S68251 (139bp)
Habib,S.L., Srikanth,N.S., Scappaticci,F.A., Faletto,M.B.,
Maccubbin,A., Farber,E., Ghoshal,A.K. and Gurtoo,H.L.
Altered expression of cytochrome P450 mRNA during chemical-induced
hepatocarcinogenesis and following partial hepatectomy
Toxicol. Appl. Pharmacol. 124, 139-148 (1994)
rat 2C cluster in chromosome order
CYP2C11 rat
PIR A60782 (500 amino acids)
Stroem, A., Mode, A., Zaphiropoulos, P., Nilsson, A.G.,
Morgan, E., Gustafsson, J.A.
Cloning and pretranslational hormonal regulation of
testosterone 16alpha-hydroxylase (P-450-16alpha) in male
rat liver.
Acta Endocrinol. 118, 314-320 (1988)
rat 2C cluster in chromosome order
CYP2C11 rat
PIR A60783 (500 amino acids)
Zaphiropoulos, P.G., Mode, A., Stroem, A., Husman, B.,
Andersson, G., Gustafsson, J.A.
Sequence and regulation of two growth-hormone-controlled,
sex-specific isozymes of cytochrome P-450 in rat liver,
P-450-15beta and P-450-16alpha.
Acta Med. Scand. Suppl. 723, 161-167 (1988)
rat 2C cluster in chromosome order
CYP2C11 rat
GenEMBL X79081 (2140bp) PIR S44310 (56 amino acids)
Strom,A., Equchi,H., Mode,A., Tollet,P., Stromstedt,P.E. and
Gustafson,J.
Characterization of the proximal promoter and two silencer elements
in the CYP2C gene expressed in rat liver.
DNA Cell Biol. 13, 805-819 (1994)
rat 2C cluster in chromosome order
CYP2C11 rat
PIR S26818 (500 amino acids)
Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
J. Biochem. (1986) 100, 1359-1371
Purification and characterization of three male-specific and
one female-specific forms of cytochrome P-450 from rat
liver microsomes.
rat 2C cluster in chromosome order
CYP2C11 rat
GenEMBL U33173(1856bp)
Yoshioka,H., Morohashi,K., Sogawa,K., Miyata,T., Kawajiri,K.,
Hirose,T., Inayama,S., Fujii-Kuriyama,Y. and Omura,T.
Structural analysis and specific expression of microsomal
cytochrome P-450(M-1) mRNA in male rat livers.
J. Biol. Chem. 262 (4), 1706-1711 (1987)
Erratum:[J Biol Chem 1986 Jun 15;262(17):8438]]
Biagini,C. and Celier,C.
cDNA-directed expression of two allelic variants of cytochrome P450
2C11 using COS1 and SF21 insect cells.
Arch. Biochem. Biophys. 326 (2), 298-305 (1996)
rat 2C cluster in chromosome order
CYP2C11 rat
GenEMBL J02657
72% to CYP2C6_v1
243377899 MDPVLVLVLTLSSLLLLSLWRQSFGRGKLPPGPTPLPIIGNTLQIYMKDIGQSIKK 243378066
243379842 FSKVYGPIFTLYLGMKPFVVLHGYEAVKEALVDLGEEFSGRGSFPVSERVNKGL 243380003
243380160 GVIFSNGMQWKEIRRFSIMTLRTFGMGKRTIEDRIQEEAQCLVEELRKSK 243380309
GAPFDPTFILGCAPCNVICSIIFQNRFDYKDPTFLNLMHRFNENFRLFSSPWLQVCNT
FPAIIDYFPGSHNQVLKNFFYIKNYVLEKVKEHQESLDKDNPRDFIDCFLNKMEQEKH
NPQSEFTLESLVATVTDMFGAGTETTSTTLRYGLLLLLKHVDVTAKVQEEIERVIGRN
RSPCMKDRSQMPYTDAVVHEIQRYIDLVPTNLPHLVTRDIKFRNYFIPKGTNVIVSLS
SILHDDKEFPNPEKFDPGHFLDERGNFKKSDYFMPFSA
243416959 GKRICAGEALARTELFLFFTTILQNFNLKSLVDVKDIDTTPAISGFGHLPPFYEACFIPVQRADSLSSHL*
243417171
CYP2C12 rat
Swiss B60783 (490 amino acids)
Zaphiropoulos, P.G., Mode, A., Stroem, A., Husman, B.,
Andersson, G., Gustafsson, J.A.
Sequence and regulation of two growth-hormone-controlled,
sex-specific isozymes of cytochrome P-450 in rat liver,
P-450-15beta and P-450-16alpha.
Acta Med. Scand. Suppl. 723, 161-167 (1988)
rat 2C cluster in chromosome order
CYP2C12 rat
PIR S26819 (490 amino acids)
Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
J. Biochem. (1986) 100, 1359-1371
Purification and characterization of three male-specific and
one female-specific forms of cytochrome P-450 from rat
liver microsomes.
rat 2C cluster in chromosome order
CYP2C12 rat
PIR B41425 (19 amino acids)
Imaoka, S., Kamataki, T. and Funae, Y.
Purification and characterization of six cytochromes P-450
from hepatic microsomes of immature female rats.
J. Biochem. 102, 843-851 (1987)
rat 2C cluster in chromosome order
CYP2C12 rat
GenEMBL J03786
80% to 2C13
MDPFVVLVLSLSFLLLLYLWRPSPGRGKLPPGPTPLPIFGNFLQ
IDMKDIRQSISNFSKTYGPVFTLYFGSQPTVVLHGYEAVKEALIDYGEEFSGRGRMPV
FEKATKGLGISFSRGNVWRATRHFTVNTLRSLGMGKRTIEIKVQEEAEWLVMELKKTK
GSPCDPKFIIGCAPCNVICSIIFQNRFDYKDKDFLSLIENVNEYIKIVSTPAFQVFNA
FPILLDYCPGNHKTHSKHFAAIKSYLLKKIKEHEESLDVSNPRDFIDYFLIQRCQENG
NQQMNYTQEHLAILVTNLFIGGTETSSLTLRFALLLLMKYPHITDKVQEEIGQVIGRH
RSPCMLDRIHMPYTNAMIHEVQRYIDLAPNGLLHEVTCDTKFRDYFIPKGTAVLTSLT
SVLHARKEFPNPEMFDPGHFLDENGNFKKSDYFMPFSAGKRKCVGEGLASMELFLFLT
TILQNFKLKSLSDPKDIDINSIRSEFSSIPPTFQLCFIPV
CYP2C13 rat
GenEMBL X79810 (1944bp)
Legraverend,C., Eguchi,H., Strom,A., Lahuna,O., Mode,A.,
Tollet,P., Westin,S. and Gustafsson,J.A.
Transactivation of the rat CYP2C13 gene promoter involves HNF-1,
HNF-3 and members of the orphan receptor subfamily.
Biochemistry 33, 9889-9897 (1994)
rat 2C cluster in chromosome order
CYP2C13 rat
PIR S26820 (30 amino acids)
Matsumoto, T., Emi, Y., Kawabata, S. and Omura, T.
Purification and characterization of three male-specific and
one female-specific forms of cytochrome P-450 from rat
liver microsomes.
J. Biochem. 100, 1359-1371 (1986)
rat 2C cluster in chromosome order
CYP2C13v1 rat
100% first 5 exons
Note this seq also on 100.0% Un ++ 17276272 17282257
Exons 6-9 are on 99.1% Un ++ 17323193 17358099 2 aa diffs to 2C13 J02861
CYP2C12 is also on this same contig 99.6% Un ++ 17388090 17446950 2 aa diffs
Minus Strand HSPs:
245246208 MDPVVVLLLSLFFLLFLSLWRLSSGRGKLPPGPTPLPIIGNFFQVDMKDIRQSLTN (0) 245246041
245244920 FSKTYGPVYTLYVGSQPTVVLHGYEALKEALVDHGEEFSGRGRLPICEKVAKGQ (1) 245244759
245244599 GIAFSHGNVWKATRHFTVKTLRNLGMGKGTIEDKVQEEAKWLVKELKKTN 245244450
245240888 GSPCDPQFIMGCAPGNVICCIILQNRFDYEDKDFLNLIEKVNEAVKIISSPGIQ (0) 245240727
245239607 VFNIFPILLDYCPGNHNIYLKNYTWVKSYLLEKIKEHEESLDVSNPRDFIDYFLIERNQ 245239431
CYP2C13v1 rat
GenEMBL J02861
80% to 2C12
MDPVVVLLLSLFFLLFLSLWRPSSGRGKLPPGPTPLPIIGNFFQ
VDMKDIRQSLTNFSKTYGPVYTLYVGSQPTVVLHGYEALKEALVDHGEEFSGRGRLPI
CEKVAKGQGIAFSHGNVWKATRHFTVKTLRNLGMGKGTIEDKVQEEAKWLVKELKKTN
GSPCDPQFIMGCAPGNVICSIILQNRFDYEDKDFLNLIEKVNEAVKIISSPGIQVFNI
FPILLDYCPGNHNIYFKNHTWLKSYLLEKIKEHEESLDVSNPRDFIDYFLIERNQ
ENANQWMNYTLEHLAIMVTDLFFAGIETVSSTMRFALLLLMKYPHVT
AKVQEEIDHVIGRH
RSPCMQDRSHMPYTNAMVHEVQRYIDIGPNGLLHEVTCDTKFRNYFIPKGTAVLTSLT
SVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFIPFSAGKRMCLGESLARMELFLFLT
TILQNFKLKSLVDPKDINTTPICSSLSSVPPTFQMRFIPL
CYP2C13v2 rat
Not in figure probable 2C13 allele NM_138514 7AA DIFFS TO 2C13v1 (98%)
80% to 2C12 (temp name = CYP2CNEWA)
MDPVVVLLLSLFFLLFLSLWRLSSGRGKLPPGPTPLPIIGNFFQ
VDMKDIRQSLTNFSKTYGPVYTLYVGSQPTVVLHGYEALKEALVDHGEEFSGRGRLPI
CEKVAKGQGIAFSHGNVWKATRHFTVKTLRNLGMGKGTIEDKVQEEAKWLVKELKKTN
GSPCDPQFIMGCAPGNVICCIILQNRFDYEDKDFLNLIEKVNEAVKIISSPGIQVFNI
FPILLDYCPGNHNIYLKNYTWVKSYLLEKIKEHEESLDVSNPRDFIDYFLIERNQENA
NQWMNYTLEHLAIMVTDLFFAGIETVSSTMRFALLLLMKYPHVTAKVQEEIDHVIGRH
RSPSMQDRSHMPYTNAMVHEVQRYIDIGPNGLLHDVTCDTKFRNYFIPKGTAVLTSLT
SVLHDSKEFPNPEMFDPGHFLDENGNFKKSDYFIPFSAGKRMCLGESLARMELFLFLT
TILQNFKLKSLVDPKDINTTPICSSLSSVPPTFQMRFIPL
CYP2C13-de1b2b rat
frag 7 Exon 1 76% to 2C13 Minus Strand
245307855 MDPIVVLVLSLSCLLFLSLWRNNSRRGKLPPGPTPLPIIRNYLQLDMKDIC*SLTK (0) 245307688
frag 6 Exon 2 83% to 2C13 Minus Strand
245292652 FSKTYGPVYTLYFGSQPTVLLYGYEALKEALIDYGEAFSGRGRIPIHEKVSKGQ 245292491
CYP2C13-se1[6] rat
frag h 72% to 2C13 exon 6 plus strand
100% to seq s 70% to 2C12 exon 6
244165142 ENGNQQMNYTQEHLATMVTDLL 244165207
244165209 FGGRETLNSTMRFAFLFLMKYPYTT 244165284
rat 2C cluster in chromosome order
CYP2C13-se2[6:7] rat
frag s Exons 6-7 minus strand 72% to 2C12 exon 6 100% to seq h
243766431 ENGNQQMNYTQEHLATMVTDLL 243766366
243766364 FGGRETLNSTMRFAFLFLMKYPYTT 243766290
243760156 XQINEEIGQVIWRHHSPSMLDWSHMIYTNAMVHEVQRYIDLAPNGVVCEVNCDTKYPRDYFIPK 243759968
rat 2C cluster in chromosome order
CYP2C13-se3[1:2:3:2:3:] rat
frag f Exons 1,2,3,2,3 exon 1 = 66% to 2C13 Minus Strand
exons 2,3 = 57% to 2C13
two identical copies of exons 2,3 100% to seq v exons 2,3
244215468 SQSFLLLLSLSSQISSKGKLPLDPTSLPILGYFF*VLMKDICQSLIN 244215328
244214467 FLKTSGPLYTQHFSLQPAVVFCGYAAVKGAFVDHSR*FS*RGWFSIFGKFSKVQ 244214306
244214137 GIGFSHKNVWKVKRFFTLITLKNLHMGNDNIKNKVQEEAQCLVKELKKIN 244213988
244213484 R*FS*RGWFSIFGKFSKVQ 244213428
244213259 GIGFSHKNVWKVKRFFTLITLKNLHMGNDNIKNKVQEEAQCLVKELKKIN 244213110
CYP2C13-se4[1:2:3] rat
frag v Exon 1 (+) 59% to 2C13
243678671 FLLLLSLSSQISSKGKLPLDPTSLPILGYFF*VLMKDICQSLIN 243678802
Exon 2 (+) 48% to 2C79
243679647 FLKTSGPLYTQHFSLQPAVVFCGYAAVKGAFVDHSR*FS*RGWFSIFGKFSKVQ 243679808
Exon 3 (+) 100% to seq f
243679977 GIGFSHKNVWKVKRFFTLITLKNLHMGNDNIKNKVQEEAQCLVKELKKIN 243680126
rat 2C cluster in chromosome order
CYP2C14 rabbit
CYP2C15 rabbit
CYP2C16 rabbit
CYP2C17X human
discontinued number See CYP2C18/19
CYP2C18 human
GenEMBL L16869 to L16876 Swiss P33260 (490 amino acids)
Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
Cloning and expression of complementary DNAs for multiple
members of the human cytochrome P450IIC subfamily.
Biochemistry 30, 3247-3255 (1991)
de Morais,S.M., Schweikl,H., Blaisdell,J.A. and Goldstein,J.A.
Gene structure and upstream regulatory regions of human
CYP2C9 and CYP2C18.
Biochem. Biophys. Res. Commun. 194, 194-201 (1993)
Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
Correction: Cloning and expression of complementary DNAs
for multiple members of the human cytochrome P450IIC subfamily.
Biochemistry 32, 1390-1390 (1993)
CYP2C18 human
GenEMBL S63419 S63421 S63424 S63426
X56452 (multiple genomic fragments) PIR S45369 (56 amino acids)
Ged,C. and Beaune,P.
Partial sequence and polymerase chain reaction-mediated analysis of
expression of the human CYP2C18 gene
Pharmacogenetics 2, 109-115 (1992)
CYP2C18 human
PIR A61269 (490 amino acids)
Furuya, H., Meyer, U.A., Gelboin, H.V. and Gonzalez, F.J.
Polymerase chain reaction-directed identification, cloning,
and quantification of human CYP2C18 mRNA.
Mol. Pharmacol. 40, 375-382 (1991)
CYP2C18/19 human
GenEMBL M61858 J05326 (1276bp) Swiss P33259 (270 amino acids)
Goldstein,J.A., Raucy,J.L., Blaisdell,J.A., Faletto,M.B. and
Romkes,M.
Cloning and expression of complementary DNAs for multiple members
of the human cytochrome P450IIC subfamily
Biochemistry 30, 3247-3255 (1991)
This sequence named 2C17 was later found to be a splice of 2C18 amd
2C19. Therefore, there is no 2C17 sequence.
CYP2C18/19 human
GenEMBL L07093 (2395bp)
Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
Correction: Cloning and expression of complementary cDNAs for
multiple members of the human cytochrome P450IIC subfamily
Biochemistry 32, 1390-1390 (1993)
CYP2C18 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
3 aa diffs to rhesus 2C18, 95% to human 2C18 only 80% to 2C19
complete sequence
CYP2C18 Macaca fasicularis (cynomolgus monkey)
No accession
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
96% to 2C18 human, 81% to 2C9, 81% to 2C19, 76% to 2C8
3 amino acid diffs to Unos seq.
CYP2C18 Macaca mulatta (Rhesus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
3 aa diffs to M. fasicularis 2C18
complete sequence
CYP2C19 human
Swiss P33261 (490 amino acids)
Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
Cloning and expression of complementary DNAs for multiple
members of the human cytochrome P450IIC subfamily.
Biochemistry 30, 3247-3255 (1991)
CYP2C19 human
GenEMBL L31506 (129bp)
GenEMBL L31507 (129bp)
De Morais,S.M.F., Wilkinson,G.R., Blaisdell,J.A., Nakamura,K.,
Meyer,U.A. and Goldstein,J.A.
The major genetic defect responsible for the polymorphism of
S-mephenytoin metabolism in humans
J. Biol. Chem. 269, 15419-14522 (1994)
CYP2C19 human
GenEMBL L32982 (329bp) wild type exon 4
GenEMBL L32983 (329bp) mutant exon 4
De Morais,S.M.F., Wilkinson,G.R., Blaisdell,J.A., Meyer,U.A.,
Nakamura,K. and Goldstein,J.A.
Identification of a new genetic defect responsible for the
polymorphism of S-mephenytoin metabolism in Japanese
Mol. Pharmacol. 46, 594-598 (1994)
CYP2C19 human
PIR S38753 (16 amino acids)
Wrighton, S.A., Stevens, J.C., Becker, G.W., and van den Branden,M.
Isolation and characterization of human liver cytochrome P450
2C19: correlation between 2C19 and S-mephenytoin
4'-hydroxylation.
Arch. Biochem. Biophys. 306, 240-245 (1993)
CYP2C20/2C8 Macaca fasicularis (cynomolgus monkey)
GenEMBL S53046 (1901bp) Swiss P33262 (490 amino acids)
PIR S28166 (490 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP2C8 will be the preferred name for this seq in the future.
CYP2C20/2C8 Macaca fasicularis (cynomolgus monkey)
PIR A60466 (22 amino acids)
Ohi, H., Toratani, S., Komori, M., Miura, T., Kitada, M. and
Kamataki, T.
Comparative study of cytochrome P-450 in liver microsomes. A
form of monkey cytochrome P-450, P-450-MK1,
immunochemically cross-reactive with antibodies to rat
P-450-male.
Biochem. Pharmacol. 38, 361-365 (1989)
CYP2C8 will be the preferred name for this seq in the future.
CYP2C20/2C8 Macaca mulatta (rhesus monkey) name change from CYP2C74
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP2C8, 78% to CYP2C19, probable ortholog of CYP2C8
formerly CYP2C74. There are only 3 amino acid differences to
Macaca fasicularis (cynomolgus monkey) GenEMBL S53046
Since this is the clear ortholog of that earlier sequence
the name has been changed to reflect the orthology.
CYP2C8 will be the preferred name for this seq in the future.
CYP2C21 Canis familiaris (dog)
NW_876285.1: 8748112-8724707
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
70% to human 2C19
MDLFIVLVICLSCLISFFLWNQNRAKGKLPPGPTPLPIIGNILQINTKNVSKSLSKLAENYGPVFTVYFGMKPTV
VLYGYEAVKEALIDRSEEFSGRGHFPLLDWTIQGLGIVFSNGEKWKQTRRFSLTVLRNMGMGKKTVEDRIQEEAL
YLVEALKKTNASPCDPTFLLGCAPCNVICSIIFQNRFEYDDKDFLTLLEYFHENLLISSTSWIQLYNAFPLLIHY
LPGSHHVLFKNIANQFKFISEKIKEHEESLNFSNPRDFIDYFLIKIEKEKHNKQSEFTMDNLIITIWDVFSAGTE
TTSTTLRYGLLVLLKHPDVTAKVQEEIHRVVGRHRSPCMQDRSCMPYTDAVVHEIQRYIDLVPNNLPHSVTQDIK
FREYLIPKGTTILTSLTSVLHDEKGFPNPDQFDPGHFLDENGSFKKSDYFMAFSAGKRVCVGEGLARMELFLLLT
NILQHFTLKPLVDPKDIDTTPIANGLGATPPSYKLCFVPV*
CYP2C22 rat
GenEMBL M58041
61% to 2C79
245425985 MALFIFLGIWLSCLVFLFLWNQHHVRRKLPPGPTPLPIFGNILQVGVKNMSKSMCM 245425818
LAKEYGPVFTMYLGMKPTVVLYGYEVLKEALIDRGEEFSDKMHSSM
LSKVSQGLGIVFSNGEIWKQTRRFSLMVLRSMGMGKRTIENRIQEEVVYLLEALRKTN
GSPCDPSFLLACVPCNLISSVIFQHRFDYSDEKFQKFIENFHTKIEILASPWAQLCSA
YPVLYYLPGIHNKFLKDVTEQKKFILMEINRHRASLNLSNPQDFIDYFLIKMEKEKHN
EKSEFTMDNLIVTIGDLFGAGTETTSSTIKYGLLLLLKYPEVTAKIQEEITRVIGRHR
RPCMQDRNHMPYTDAVLHEIQRYIDFVPIPLPRKTTQDVEFRGYHIPK
GTSVMACLTSALHDDKEFPNPEKFDPGHFLDEKGNFKKSDYFMAFSA
GRRACIGEGLARMEMFLILTSILQHFILKPLVNPEDIDTTPVQPGLLSLPPPFQLCFIPV
rat 2C cluster in chromosome order
CYP2C22-se2[1:2] rat
frag 9 Exon 1 61% to 2C22 Minus Strand
245347583 MDLFIILWICFACLSLFFLWNQLHYKEKLPPGPVPLPIVGNILQVNIKSIIKSLNI (0) 245347416
frag 8 Exon 2 79% to 2C22 Minus Strand
245334622 LAKEYGPVFTVYLGMKPTVVLHGHKALKEALIDRANEFSVKMQSSLLSKESQGL (1) 245334461
CYP2C23 rat
GenEMBL U04733 (1919bp)
Karara,A., Makita,K., Jacobson,H.R., Falck,J.R.,
Guengerich,F.P., DuBois,R.N.and Capdevila,J.H.
Molecular cloning, expression, and enzymatic characterization of the
rat kidney cytochrome P-450 arachidonic acid epoxygenase.
J. Biol. Chem. 268, 13565-13570 (1993)
rat 2C cluster in chromosome order
CYP2C23 rat
GenEMBL S67064 (265bp)
Imaoka,S., Wedlund,P.J., Ogawa,H., Kimura,S., Gonzalez,F.J.
and Kim,H.Y.
Identification of CYP2C23 expressed in rat kidney as an arachadonic
acid epoxygenase.
J. Pharmacol. Exp. Ther. 267, 1012-1016 (1993)
rat 2C cluster in chromosome order
CYP2C23 rat
PIR S29817 (20 amino acids)
Marie, S.; Roussel, F.; Cresteil, T.
Age- and tissue-dependent expression of CYP2C23 in the rat.
Biochim. Biophys. Acta 1172, 124-130 (1993)
note: This sequence is diiferent from GenEMBL U04733 and S67064
by one amino acid. PIR S13101, SwissProt P24470 and GenEMBL
X55446 are all equivalent, but they have a frame shift in the sequence
in the region of this 20 amino acid fragment. Amino acids 38-54 are affected.
rat 2C cluster in chromosome order
CYP2C23 rat
GenEMBL X55446
59% to 2C11
MELLGFTTLALVVSVTCLSLLSVWTKLRTRGRLPPGPHPPSHYW
ESTATEPQGHPASLSKLAKEYGPVYTLYFGTSPTVVLHGYDVVKEALLQQGDEFLGRG
PLPIIEDTHKGYGLIFSNGERWKVMRRFSLMTLRNFGMGKRSLEERVQEEAWCLVEEL
QKTKAQPFDPTFILACAPCNVICSILFNDRFQYNDKTFLNLMDLLNKNFQQVNSVWCQ
MYNLWPTIIKYLPGKHIEFAKRIDDVKNFILEKVKEHQKSLDPANPRDYIDCFLSKIE
EEKDNLKSEFHLENLAVCGSNLFTAGTETTSTTLRFGLLLLMKYPEVQAKVHEELDRV
IGRHQPPSMKDKMKLPYTDAVLHEIQRYITLVGSSLPHAVVQDTKFRDYVIPKGTTVL
PMLSSVMLDQKEFANPEKFDPGHFLDKNGCFKKTDYFVPFSLGKRACVGESLARMELF
LFFTTLLQKFSLKTLVEPKDLDIKPITTGIINLPPPYKLCLVPR
CYP2C24 rat
GenEMBL S59647 (226bp)
GenEMBL S59648 (187bp)
GenEMBL S59652 (380bp)
Zaphiropoulos,P.G.
Differential expression of cytochrome P450 2C24 and transcripts
in rat kidney and prostate: evidence indicative of alternative
and possibly trans splicing events.
Biochem. Biophys. Res. Commun. 192, 778-786 (1993)
rat 2C cluster in chromosome order
CYP2C24 rat
Swiss P33273 (434 amino acids) PIR PT0435 (302 amino acids)
PIR JH0451 (434 amino acids)
Zaphiropoulos,P.G.
cDNA cloning and regulation of a novel rat cytochrome P450 of the 2C
gene sufamily (P450IIC24).
Biochem. Biophys. Res. Commun. 180, 645-651 (1991)
rat 2C cluster in chromosome order
CYP2C24 rat
92% to 2C80, M86678 has alternative splice first exon seen only in M86678
exons 2-4 only 2 aa diffs to 2C24 on M86678
no ESTs contain the yellow region but CK481568.1 covers exons 1,2,3,4
CO565602.1 matched the end of the gene sequence and extends it a little 6 aa
Used this EST to blast the trace files to find the end of exon 7
MDPVLVLVLTLSCLLLLSLWRQSSGRGKLPPGPTPLPIIGNILQIDVKDISKSFTN CK481568.1 exon 1
QLSCSRKFGLTCGPEAQ rat repeat seq found in many rat BACs
243522306 FTDKLTAKCHSSVSLHIDLPGNLL 243522235 yellow region not P450 seq.
243522073 FSKIYGPVFTLYFGPKPTVVVHGYEAVKEALDDLGEEFSGRGSFPIVERMNNGL 243521912
243521366 GVIFSNGTKWKELRHFSLMTLRNFGMGKRSIEDRIQEEASCLVEELRKTN 243521217
243518830 GSLCDPTFILSCAPSNVICSVVFHNRFDYKDENFLNLMEKLNENFKILNSPWMQ 243518669
VCNALPAFIDYLPGSHNRVIKNFAEI 676
677 KSYILRRVKEHQETLDMDNPRDFIDCFLIKMEQEKHNPRTEFTIEILMATVSDVFVAGSE 856
857 TTSTTLRYGLLLLLKHIEVT
gnl|ti|132779224 rts18e73.g from trace files for exon 7
AKVQEEIDHVIGRHRRPCMQDRTRMPYTDAMVHEIQRYINLIPNNVPHAATCNVRFRNYVIPK
rat 2C cluster in chromosome order
CYP2C25 Mesocricetus auratus (Syrian hamster)
GenEMBL X63022 (1829bp, incorrectly given as X60322 in Table 3
of the 1993 nomenclature update)
Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
Sex-related difference in the expression of cytochrome P450 in
hamsters: cDNA cloning and examination of the expression of three
distinct CYP2C cDNAs.
Molec. Pharmacol. 45, 228-236 (1994)
CYP2C26 Mesocricetus auratus (Syrian hamster)
GenEMBL D11435 (1808bp) Swiss P33263 (490 amino acids)
Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
Sex-related difference in the expression of cytochrome P450 in
hamsters: cDNA cloning and examination of the expression of three
distinct CYP2C cDNAs.
Molec. Pharmacol. 45, 228-236 (1994)
CYP2C27 Mesocricetus auratus (Syrian hamster)
GenEMBL D11436 (1784bp) Swiss P33264 (490 amino acids)
Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
Sex-related difference in the expression of cytochrome P450 in
hamsters: cDNA cloning and examination of the expression of three
distinct CYP2C cDNAs.
Molec. Pharmacol. 45, 228-236 (1994)
CYP2C28 Mesocricetus auratus (Syrian hamster)
GenEMBL D11437 (1556bp) Swiss P33265 (490 amino acids)
Sakuma,T., Masaki,K., Itoh,S., Yokoi,T. and Kamataki,T.
Sex-related difference in the expression of cytochrome P450 in
hamsters: cDNA cloning and examination of the expression of three
distinct CYP2C cDNAs.
Molec. Pharmacol. 45, 228-236 (1994)
Cyp2c29 mouse
GenEMBL D17674 (1751bp) also BC013895
Matsunaga,T., Watanabe,K., Yamamoto,I., Negishi, M.,
Gonzalez,F.J. and Yoshimura, H.
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2,
a microsomal aldehyde oxygenase.
Biochim. Biophys. Acta 1184, 299-301 (1994)
Cyp2c29 mouse
PIR A61268 (16 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
Cyp2c29v2 mouse
no accession number
Gang Luo and Joyce A. Goldstein
clone M2c9k
submitted to Nomenclature Committee
CYP2C30 rabbit
GenEMBL D26153
Noshiro,M., Ishida,H. and Okuda,K.
unpublished (1993)
CYP2C31 Capra hircus (dwarf goat)
GenEMBL X76502 (1185bp) PIR JC2199 (284 amino acids)
PIR S39314 (284 amino acids)
Zeilmaker,W.M., Van't Klooster,G.A.E., Gremmels-Gerhmann,F.J.
Van Miert,A.S.J. and Horbach,G.J.M.J.
cDNA and deduced amino acid sequence of a dwarf goat liver
cytochrome P450-fragment belonging to the CYP2C gene subfamily.
Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
CYP2C32 pig
GenEMBL U35733.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
most similar to 2C24
Clone name CL1
CYP2C33v1 pig
GenEMBL U35837 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name CL7
CYP2C33v2 pig
GenEMBL U35838 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name CL8
CYP2C33v3 pig
GenEMBL U35839 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name PF1
CYP2C33v4 Sus scrofa (pig)
GenEMBL AB052257
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
2 amino acids diffs with 2C33v1 and v2
clone name c296
CYP2C34v1 pig
GenEMBL U35840.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name PF15
CYP2C34v2 pig
GenEMBL U35841.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name CL6
CYP2C34v3 pig
GenEMBL U35842.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name Cl12
CYP2C34v4 pig
GenEMBL U35843.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name Cl13
CYP2C35 pig
GenEMBL U35844.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name PF11/14
CYP2C36 pig
GenEMBL U35845.1 (681bp)
Zaphiropoulos,P.G., Skantz,A., Eliasson,M. and Ahlberg,M.B
Cytochrome P450 genes expressed in porcine ovaries: identification of novel
forms, evidence for gene conversion, and evolutionary relationships.
Biochem. Biophys. Res. Commun. 212, 433-441 (1995)
Clone name PF13
CYP2C37 macaque [name conflict, reassigned to CYP2C43]
no accession number
S. Ohmori
submitted to Nomenclature Committee
Cyp2c37 mouse
AF047542 NM_010001, also AK005017
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
Cloning and expression of murine CYP2Cs and their ability to
metabolize arachidonic acid.
Arch Biochem Biophys. 357, 45-57 1998.
clone M2c10b
submitted to Nomenclature Committee
Cyp2c38 mouse
AF047725
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
Cloning and expression of murine CYP2Cs and their ability to
metabolize arachidonic acid.
Arch Biochem Biophys. 357, 45-57 1998.
clone M2c13f
submitted to Nomenclature Committee
Cyp2c39 mouse
AF047726 NM_010003
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
Cloning and expression of murine CYP2Cs and their ability to
metabolize arachidonic acid.
Arch Biochem Biophys. 357, 45-57 1998.
clone M2c9d
submitted to Nomenclature Committee
Cyp2c39-ie6b mouse
GenEMBL NT_039689.1
Internal exon 6 (duplicate exon)
5895730 ANHIQQAEFSLENLACTINNLFAAGTETTSTSLINARLLFVRDPNVT 5895870
Cyp2c40 mouse
AF047727 NM_010004 (NW_000147 exons 2-6 only)
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA.
Cloning and expression of murine CYP2Cs and their ability to
metabolize arachidonic acid.
Arch Biochem Biophys. 357, 45-57 1998.
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C
in murine intestinal tract.
Mol Pharmacol. 58, 279-87 2000
clone M2c9h
submitted to Nomenclature Committee
CYP2C41 dog
NM_001003334, AF016248
Stephen R. Bai and Joyce A. Goldstein
clone M2c9h
submitted to Nomenclature Committee
MDPVVVLVLCLSCCLLLSLWKQSSRKGKLPPGPTPLPFIGNILQ
LDKDINKSLSNLSKAYGPVFTLYFGMKPTVVLHGYDAVKETLIDLGEEFSARGRFPIA
EKVSGGHGIIFTSGNRWKEMRRFALTTLRNLGMGKSDLESRVQEEACYLVEELRKTNA
LPCDPTFVLGCASCNVICSIIFQNRFDYTDQTLIGFLEKLNENFRILSSPWIQAYNSF
PALLHYLPGSHNTIFKNFAFIKSYILEKIKEHQESFDVNNPRDFIDYFLIKMEQEKHN
QPLEFTFENLKTIATDLFGAGTETTSTTLRYGLLLLLKHPEVTVKVQEEIDRVIGRHQ
SPHMQDRSRMPYTNAVLHEIQRYIDLVPNSLPHAVTCDVKFRNYVIPKGTTILISLSS
VLSDEKEFPRPEIFDPAHFLDDSGNFKKSDYFMAFSAGKRICVGEGLARMELFLFLTT
ILQKFTLKPLVDPKDIDTTPLASGFGHVPPTYQLCFIPV
CYP2C42 pig
GenEMBL Z93098 (1307bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
clone 10b03
CYP2C42P1 pig
GenEMBL Z93100 (1758bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
clone 15d09 (pseudogene)
CYP2C43 Macaca mulatta (rhesus monkey)
no accession number
Matsunaga T, Ohmori S, Ishida M, Sakamoto Y, Nakasa H, Kitada M.
Molecular Cloning of Monkey CYP2C43 cDNA and Expression in Yeast.
Drug Metab Pharmacokinet. 2002;17(2):117-24.
submitted to Nomenclature Committee
[name conflict, formerly CYP2C37 reassigned to CYP2C43]
CYP2C43 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2C9v1
92% to 2C9 human, 93% to 2C75, 77% to 2C20, 77% to 2C74
99% to rhesus 2C43
Cyp2c44 mouse
no accession number
Christian Helvig and Jorge H. Capdevila
submitted to nomenclature committee Oct. 2, 1998
most similar to CYP2C23 (87% identical)
MELLGLPTLALLVLVMSLSLLSVWTKMRTGGRLPPGPTPLPIIGNILQLDLKDIPASLSK
LAKEYGPVYTLYFGSWPTVVLHGYDVVKEALLNQGDEFLGRGPLPIIEDSQKGH
GIVFSEGERWKLLRRFSLMTLKNFGMGKRSLEERVQEEARCLVEELHKTE
AQPFDPTFILACAPCNVICSILFNERFPYNDKTFLNLMDLLNKNFYQLNSIWIQ
MYNLWPTIMKYIPGKHREFSKRLGGVKNFILEKVKEHQEFLDPANPRDYIDCFLSKIEE
EKHSLKSDFNLENLAICGSNLFTAGTETTSTTLRFGLLLLVKHPEVQ
AKVHEELDRVIGRHQPPSMKDKMKLPYTDAVLHEIQRYITLLPSSLPHAVVQDTKFRHYVIPK
GTAVFPFLSSILLDQKEFPNPEKFDPGHFLDKNGCFKKTDYFVPFSL
GKRSCVGEGLARMELFLFFTTILQKFSLKALVEPKDLDIKPVTTGLFNLPPPYKLRLVPR
CYP2C45 gallus gallus (chicken)
No accession number
Manuel Baader
Submitted to nomenclature committee Nov. 22, 1999
57% identical to CYP2C9
CYP2C46 rat
No accession number
Lars von Buchholtz
Submitted to nomenclature committee March 6, 2000
91% to 2C24
CYP2C47 Phascolarctos cinereus (koala)
No accession number
Ross McKinnon
Submitted to nomenclature committee May 25, 2000
60% identical to many 2C sequences
CYP2C48 Phascolarctos cinereus (koala)
No accession number
Brett Jones and Ross McKinnon
Submitted to nomenclature committee Nov. 6, 2000
92% identical to 2C47
CYP2C49 Sus scrofa (pig)
GenEMBL AB052258
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
92% to 2C35 and 2C34v1, v3, v4
80% to 2C18,78% to 2C9, 77% to 2C19 and 75% to 2C8
clone name c195
Cyp2c50 mouse
GenEML BC011222.1, NT_039692
GSS AZ589908 one exon only
ESTs AI118193 ue34e02.x1, opposite end = AI098787 ue34e02.y1
AI097740 AI117011 AI119501 AI314482 BF385641 AI528254
AA968308 AI876138 AI097678 AI226027 BF384486 BF659471 AI529923
AI266900 uj08d09.x1, opposite end AI226027 uj08d09.y1,
Joyce Golstein and Cheng-Chung Tsao
submitted to nomenclature committee 3/1/2001
94% to 2c37; 75% 2c39,2c29v2; 74% 2c38; 68% 2c40; 53% 2c44
name 2C heart
NT_039692 + strand
176707 MDPILVLVFTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQINVKDICQSFTN 176874
177228 LSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGRGRLPVFDKATNGM 177389
177552 GIIFSKGNVWKNTRRFSLTTLRNLGMGKRSIEDRVQEEARCLVEELRKTN 177701
177951 GSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKIMSTPWLQ 178112
179211 VCNTFPVLLDYCPGSHNKVFKNYACIKNFLLEKIKEHEESLDVTIPRDFIDYFLINGGQ 179387
183835 ENGNYPLKNRLEHLAITVTDLFSAGTETTSTTLRYALLLLLKYPHVT 183975
185072 AKVQEEIEHVIGKHRRPCMQDRSHMPYTDAMIHEVQRFIDLVPNSLPHEVTCDIKFRNYFIPK 185260
198149 GTNVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFST 198289
200344 GKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVPPAFQLCFIPS 200523
Cyp2c51X? mouse
No accession number
Joyce Golstein and Cheng-Chung Tsao
submitted to nomenclature committee 3/1/2001
69% to 2c29v2; 69% 2c37; 68% 2c38; 67% 2c39; 67% 2c40
no exact hits in nr, htgs, est, gss or sts on 3/5/01
name 2C aorta
note: this seq appears to be a combination between 2c52p and 2c69
it may not be a real gene
Cyp2c52-ps mouse
GenEMBL XM_140720
Joyce Golstein and Cheng-Chung Tsao
submitted to nomenclature committee 3/1/2001
78% to 2c51, 70% to 2c29v2, 2c38; 67% to 2c39, 2c37; 61% to 2c40
missing PYTD in K-helix
no exact hits in nr, htgs, est, gss or sts on 3/5/01
name 2C kidney, 2C eye
sequence shown is from Ensembl mouse version 3
628318 MDPVLVLVLTLSCLLLLS*WRQNSGRGKLPPGPTPLPIIGNILQIDVKNTGQSVGK 628367
630645 FSKVYGPVFTLYFGMKPSVVLHGYEAVKEALVDLGEGFSGRGSFPVAEKASKGL 630806
630954 GIIFSNGMKWKEIRRFSVMT 631013 frameshift
631012 LRNFGMGKRSVEDRVQEEARCLVEELRNGK 631101
636385 XAPCDPTFILGCAPCNVICSIIFQKRFDYKDQTFLNLMDKFNENFRILSTPWIQ 636425
639913 VCNTFPAIIDYFPGSHNQVLKNFSYIKKNYVLEKVKKHQESLDMENPRDFIDCFLIKMKQ 639972
710041 EKHSLQSEFTHESLVATVTDMFGAGTETTSNTLRYGLLLLLKHVDIT 710181
713060 AKVQEEIERVVGRHRSPCVQDRSHM 713134 4 aa deletion and f.s.
713136 AVVHETQRYIVLIPTNLPHSVTCDAKFRNYFIPK 713237
715864 GTTVITSLTSMLHDDKEFPNPEKFDPGYFLDERGNVKKSDYFVPFSA 716004
717828 GKRMCAGEGLTGMELFLFFTIILQNFNLKPLVDVKDIDTTPVVSGFGHVPPLYQARFIPV* 718010
Cyp2c53-ps mouse
AC078913.5 seq b assembled from parts 74% to 2c39
Old assembly included some N- and C-term parts not from this gene
TNFSKVYGPVFTLYLGMKPTVVLHGYEAVKEALIDHGEEFAVKGIFPLAEKNSK
FTLMTLKNLGMGKRNIEDRVQEEAQCLVEELRKTNG
SLCDPTFILGCAPCNVTCSIIFQNHFDYKDQDFLSLMEKINENTKIVSTPWIQ
LIVYCPGSHKTVPENAYYIEIYILKKIKEHQESLDVTNPLDFIDYYLIKCKQ
GAGTETSTTLRYALLLLMTYPEVT
Cyp2c53-ps mouse
AY227735 NW_000145
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c66 and Cyp2c29 on chr 19
Temp name 2CN6
74% to 2c29
note: this is a pseudogene. There are three stop codons
and the C-helix WXXXR motif is missing
MDLISFLMLTLFCLILLSLWSQSSGRGKLPPGPTPVPIIVSLLQLDVKNITQSSTN
FSKVYGPVFTLYLGMKPTVVLHGYEAVKEALIDHGEEFAVKGIFPLAEKNSKAL
LSGFML*FLFLFV*EFTLMTLKNLGMGKRNIEDRVQEEAQCLVEELRKTN
GSLCDPTFILGCAPCNVTCSIIFQNHFDYKDQDFLSLMEKINENTKIVSTPWIQ
VVKFSPVLIVYCPGSHKTVPENAYYIEIYILKKIKEHQESLDVTNPLDFIDYYLIKCKQ
EYHNHYSELTLKILSTTVTDFFGAGTETTSTTLRYALLLLMTYPEVT
AKIQDENDHVVGKHRNLCMQDRSHMPYTFAMIH*VQRFIDLLPTNLPHAVTCDIKFRNYIILK
GTAVITSLSSVLHDRKEFLNPEMFDPGHFLDGNGNFKKSDHFMPFSA
GKRVCVGEGLACMELFLFLTTALQNFKLKPLVHPKDINTTPVLNGFASVPLFYELCSIPL*
Cyp2c54 mouse
GenEMBL NT_039692 - strand
Darryl Zeldin
submitted to nomenclature committee 3/18/2002
clone name N1
92% to 2c50 91% to 2c37 76% to 2c29 73% to 2c38 74% to 2c39
70% to 2c40 67% to 2c55 66% to 2c53p 59% to 2c44 67% to 2c52p
68% to 2c51
160912 MDPILVLVLTLSCLFLLSLWRQSYERGKLPPGPTPLPIIGNILQIDVKDICQSFTN 160745
159630 LSRVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGDVFAGRGRLPVFDKATNGM 159469
159306 GIGFSNGSVWKNTRHFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTN 159157
158708 GSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLLEKLDEISKILSTPWLQ 158547
157443 VCNTFPALLDYCPGSHNQFFKNYAYIKNFLLEKIREHKESLDVTIPRDFIDYFLIKGAQ 157267
134958 EDDNHPLKNNFEHLAITVTDLFIGGTESMSTTLRYALLLLLKYPHVT 134818
133577 AKVQEEIEHVIGKHRRPCMQDRSHMPYTNAMIHEVQRFIDLVPNNLPHEVTCDIKFRNYFIPK 133389
127646 GTTVITSLSSVLRDSKEFPNPEKFDPGHFLDENGKFKKSDYFMPFST 127506
125732 GKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDITPMLIGLGSVPPAFQLCFIPS 125553
Cyp2c55 mouse
GenEMBL NT_039689.1 + strand
Darryl Zeldin
submitted to nomenclature committee 3/18/2002
clone name N3
71% to 2c29 70% to 2c39 70% top 2c38 69% to 2c37 69% to 2c50
65% to 2c40 58% to 2c44 53% to 2c53p 59% to 2c52p 67% to 2c54
67% to 2c51
5347110 MDPVLVLVLTLSCLLLLSLWRQNSGRGKLPPGPTPFPIIGNILQIDIKNISKSFNY 5347277
5351084 FSKVYGPVFTLYFGSKPTVVVHGYEAVKEALDDLGEEFSGRGSFQIFERINNDL 5351245
5351753 GVIFSNGTKWKELRRFSIMTLRSFGMGKRSIEDRIQEEASCLVEELRKAN 5351902
5358706 GSLCDPTFILSCAPSNVICSVIFHNRFDYKDEKFLNLMERLNENFKILNSPWMQ 5358867
5371382 VYNALPTLINYLPGSHNKVIKNFTEIKSYILGRVKEHQETLDMDNPRDFIDCFLIKMEQ 5371558
5374359 EKHNPHSEFTIESLMATVTDIFVAGTETTNITLRYGLLLLLKHTEVT 5374499
5375564 AKVQAEIDHVIGRHRSPCMQDRTRMPYTDAMVHEIQRYIDLIPNNVPHAATCNVRFRSYFIPK 5375752
5378482 GTELVTSLTSVLHDDKEFPNPEVFDPGHFLDENGNFKKSDYFMPFSI 5378622
5382398 GKRMCVGEALARTELFLILTTILQNFNLKSLVDTKDIDTTPVANTFGRVPPSYQLYFIPR 5382577
CYP2C56PX human = CYP2C-se1[7] (see below)
CYP2C57PX human = CYP2AC1P a new subfamily in mammals (see below)
CYP2C58P human
NT_008769.11|Hs10_8926
solo exons 1,2,3 between 2C19 and 2C9
same as AL133513.12
an alternative name for this sequence would be CYP2C19-de1b2b3b
8303126 LDLAAVLMLCLSCLLLLSL*TQISGRGKLPSDSTPLQVIESILQMADKDICKSSSNLSTLY 8302944
8296311 SLYFDMKLVLVLHGYEVLKKALIHHGEEFSGKGIFPVSKK 8296192
8295999 IIFSNRKPCKEIWPFLLMTLWNCGVVKRS 8295913
8295911 LGKHVQVEAHCIVWELRRTK 8295852
CYP2C59PX human = CYP2C9-de2c3c (see above)
CYP2C60PX human = CYP2C8-de6b (see above)
CYP2C61PX human = CYP2C-se2[1:2] (see below)
CYP2C62P human
AL138921 NT_030059 chromosome 10 50% to 2C8
Chr10q24.31 101999343-102031105 - strand build 33
5Mb upstream of 2C8
LAMCVTCLIFFLVWKKSPSPTPLPTIGNRLQRNPKD
CISFQLAKEYSSVYTLYFGSWPTMVFHGYKAVKEALIDQGDKSLGRGHIPIIDDAQKRY
TSAQPFDSTFILASAPCNL
CSFLFKECFQYKNETFLSLMGLLNENVK
TTVLPLLSLVLFSYKQFP
GHFLDKNGCFNKTDYFLPFSLGK
CYP2C63PX human = CYP2C-se3[1] (see below)
CYP2C64PX human = CYP2C-se4[1] (see below)
Cyp2c65 mouse
AY227733 NW_000145 also NT_039689.1
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c55 and Cyp2c66 on chr 19
Temp name 2CN4
93% to Cyp2c66 73% to 2c29
NT_039689.1 + strand
5398093 MVLGVFLGLLLTCLLLLSLWRQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRN 5398260
5406366 FSKVYGPVFTLYLGRNPAVVLHGYEAVKEAFTDHGEEFAGRGVFPVFDKFKKNC 5406527
5406732 GVVFSSGRTWKEMRRFSLMTLRNFGMGRRSIEDRIQEEARCLVDELRKTKG 5406884
5409456 EPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLTFLDILNENVEILSSPWIQ 5409614
5410489 ICNNFPAVIDYLPGRHRKLHKNFAFAEHYFLSKVKQHQESLDINNPRDFIDCFLIKMEQ 5410665
5419474 EKHNPKTEFTCENLVFTASDLFAAGTETTSTTLRYSLLLLLKYPEVT 5419614
5424846 AKVQEEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPK 5425034
5427909 GTTVIASLTSVLYDDKEFPNPEKFDPSHFLDERGKFKKSDYFFPFST 5428049
5430603 GKRICVGEGLARAELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFASVPPKFQICFIPI* 5430785
Cyp2c65-de9b mouse
GenEMBL NT_039689.1 + strand
z in Figure 2D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exon 9 between Cyp2c65 and Cyp2c66
5432237 RS*LYIPPTPGKCICVRDNLAQMKLFLFLTTILYNFNLKSVDPQELDTT 5432383
Cyp2c66 mouse
AY227734 NW_000145
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c65 and Cyp2c53p on chr 19
Temp name 2CN5
93% to Cyp2c65 73% to 2c29
MVLGVFLGLLLTCLLLLSLWKQNSQRRNLPPGPTPLPIIGNILQLDLKDISKSLRN
FSKVYGPVFTLYLGKKPAVVLHGYKAVKEALIDHGEEFAGRGTFPVADKFIRVL
GVVFSSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTK
GVPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLTFIDILNENVEILSSPWIQ
VCNNFPAIIDYLPGRHRKLLKNFDFAKHYFLAKVIQHKESLDINNPRDFIDCFLIKMEQ
EKHNPKTEFTCENLIFTASDLFAAGTETTSTTLRYSLLLLLKYPEVT
AKVQAEIDCVIGRHRSPCMQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPK
GTTVIASLTSVLYDDKEFLNPERFDPSHFLDESGKFKKSDYFFPFST
GKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKDLDTTPVANGFVSVPPKFQICFISI*
Cyp2c67 mouse
GenEMBL NW_030157.1 (aa 1-274 exons 1-5 minus strand)
GenEMBL NW_022459.1 (aa 275-320 exon 6 plus strand)
GenEMBL NW_021833.1 (aa 321-431 exons 7-8 plus strand)
Part of exon 9 not found
GenEMBL NW_020256.1 (aa 469-491 end of exon 9 plus strand)
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c39 and Cyp2c68 on chr 19
Temp name 2CN7
95% to Cyp2c40
MDPFVVLVLCLSFLLVLSLWRQRSARGNLPPGPTPLPIIGNYHLIDMKDIGQCLTN
FSKTYGPVFTLYFGSQPIVVLHGYEAMKEAFIDHGEEFSGRGRFPFFDKVTKGK
GIGFSHGNVWKATRVFTINTLRNLGMGKRTIENKVQEEAQWLMKELKKTN
GLPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGK
VNECTEILSSPGCQIFNAVPILIDYCPGRHNKFFKNHTWIKSYLLEKIKE
HEESLDVTNPRDFIDYFLIQRCQKKGIEHMEYTIEHLATLVTDLVFGGTE
SLSSTMRFALLLLMKHTHITAKVQEEIDNVIGRHRSPCMQDRNHMPYTNA
MVHEVQRYVDLGPISLVHEVTCDTKFRNYFIPKGTQVMTSLTSVLHDSTE
FPNPEVFDPGHFLDDNGNFKKSDYFVPFSAGKRICVGESLARMELFLFLT
TILQNFKLKPLVDPKDIDMTPKHSGFSKIPPNFQMCFIPVE*
Cyp2c68 mouse
GenEMBL NW_034810.1 (aa 1-161 exons 1-3 plus strand)
Exon 4 not found
GenEMBL NW_012728.1 (aa 215-273 exon 5 minus strand)
Exon 6 not found
GenEMBL NW_024952.1 (aa 321-383 exon 7, 2 copies on this contig)
GenEMBL NW_012306.1 (aa 356-431 part of exon 7 and exon 8)
Exon 9 not found
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c67 and Cyp2c40 on chr 19
Temp name 2CN8
96% to Cyp2c40
1 MDPFVVLVLC LSFLLLLSLW RQRSARGNLP PGPTPLPIIG NYHLIDMKDI
51 GQCLTNFSKI YGPVFTLYFG SQPIVILHGY EAMKEAFIDY GEEFSGRGRI
101 PVFDKVSKGK GIGFSHGNVW KATRVFTVNT LRNLGMGKRT IETKVQEEAQ
151 WLMKELKKTN GSPCDPQFII GCAPCNVICS IVFQNRFDYK DKDFLSLIGK
201 VNECTEILSS PECQIFNAVP ILIDYCPGSH NKFLKNHTWI KSYLLEKIKE
251 HEESLDVTNP RDFVDYFLIQ RRQKNGIEHM DYTIEHLATL VTDLVFGGTE
301 TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRNHMPYTNA
351 MVHEVQRYID LGPNGVVHEV TCDTKFRNYF IPKGTQVMTS LTSVLHDSTE
401 FPNPEVFDPG HFLDDNGNFK KSDYFVPFSA
Cyp2c69 mouse
GenEMBL NW_024021.1 (aa 1-56 exon 1 plus strand)
GenEMBL NW_009479.1 (aa 57-160 exon 2-3 minus strand)
GenEMBL NW_014461.1 (aa 161-214 exon 4 plus strand)
Exon 5 not found
GenEMBL NW_024085.1 (aa 276-320 exon 6 plus strand)
GenEMBL NW_021729.1 (aa 321-491 exons 7-9 plus strand)
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between Cyp2c40 and Cyp2c37 on chr 19
Temp name 2CN9
95% to Cyp2c40
1 MDPFVVLVLC LSFMLLLSLW RQRSARRNLP PGPTPLPIIG NYHLIDMKDI
51 GQCLTNFSKT YGPVFTLYFG SQPIVVLHGY EAIKEALIDH GEVFSGRGRF
101 PFFDKVSKGK GIGFSHGNVW KATRVFTVNT LRNLGMGKRT IENKVQEEAQ
151 WLMKELKKTN GSPCDPQFII GCAPCNVICS IVFQNRFDYK DKDFLSLIGK
201 VNECTEILSS PGCQIFNAVP ILIDYCPGRH NKFFKNHTWI KSYLLEKIKE
251 HEESLDVTNP RDFIDYFLIQ RRQKNGIEHM EYTIEHLATL VTDLVFGGTE
301 TLSSTMRFAL LLLMKHTHIT AKVQEEIDNV IGRHRSPCMQ DRKHMPYTNA
351 MVHEVQRYVD LGPTSLVHEV TCDTKFRNYF IPKGTQVMTS LSSVLHDSTE
401 FPNPEVFDPG HFLDDNGNFK KSDYFVPFSA GKRICVGESL ARMELFLFLT
451 TILQNFKLKP LVDPKDIDTT PKYSGFSKIP PKFQMCFIPV E*
Cyp2c70 mouse
AY227736 NW_000148 NP_663474 LOC226105, NT_039692
Hong Wang, Joyce Goldstein, Darryl Zeldin
50kb downstream of Cyp2c50 on chr 19
Temp name 2CN10
59% to Cyp2c29
MALFIFLGIWLSCFLFLFLWNQHRGRGKLPPGPTPLPIVGNILQVYVKNISKSMGM
LAKKYGPVFTVYLGMKPTVVLHGYKAMKEALIDQGDEFSDKTDSSLLSRTSQGL
GIVFSNGETWKQTRRFSLMVLRSMGMGKKTIEDRIQEEILYMLDALRKTN
GSPCDPSFLLACVPCNVISTVIFQHRFDYNDQTFQDFMENFHRKIEILASPWSQ
LCSAYPILYYLPGIHNRFLKDVTQQKKFILEEINRHQKSLDLSNPQDFIDYFLIKMEK
EKHNQKSEFTMDNLVVSIGDLFGAGTETTSSTVKYGLLLLLKYPEVT
AKIQEEIAHVIGRHRRPTMQDRNHMPYTDAVLHEIQRYIDFVPIPSPRKTTQDVEFRGYHIPK
GTSVMACLTSVLNDDKEFPNPEKFDPGHFLDEKGNFKKSDYFVAFSA
GRRACIGEGLARMEMFLILTNILQHFTLKPLVKPEDIDTKPVQTGLLHVPPPFELCFIPV
Cyp2c71-ps mouse
GenEMBL NW_000148
Between 2c69 and 2c37 on chr 19
69% to Cyp2c69
14397 CP*SYNIFF*IIHVLSYLLEKIKENEELMDVTNP*DFIDYFLIQRHQ 14537 exon 5
32761 GTTVLTPLSSVLHDSKEFPNPEMFDPDHFLDGNGNFK*SDYFMPFSAGNR 32910 exon 8
39051 MCMGESLALMELILFLTTILQNF*LKSLVDLKDNNITPVYSGL 39179
39180 F*VPPTFLVCFISV 39221 exon 9
Cyp2c71-de1b mouse
GenEMBL NW_000148
x in Figure 2D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
detritus exon 1 between Cyp2c71-ps and Cyp2c69
8628 MGPFVVLVLRLSFLLLLSL*RQRSGRGKLPPGLTPCSINGNFLQIDMKDTHQSLTN 8461
exon 1 (in opposite orientation to exons of 2c71-ps)
Cyp2c72-ps mouse
NW_000145
Hong Wang, Joyce Goldstein, Darryl Zeldin
Between 2c29and 2c38
Temp name 2CN11
88% to 2c38, 87% to 2c39
1 MDLITFLVLT LSSLILLLLW RQRSGRGRLP PGPTPFPIIG NFLQIDGKNF
51 SQSLTNFSKA YGPMFTLYLG SQPIAVLHGY EAVKEALIDH GEEFSGRRNI
101 PMAEKINNSL GVIFSNGNRW KEIRHFTLTI LRNLGMGKRN IEDRVQEEAQ
151 CLVEELRKTN
Cyp2c73-ps mouse
GenEMBL NW_000100.1 Mm14_WIFeb01_281
A chr 14 2C seq 55% to 2C29
27513950 GMGNRTIEDHI*EEACSLVDELRKTNGVRCNSTFILGC 27514063
27514066 PCNVICFIFFFQNRFDYKYQGILNENVEIVSSPWIQICNNFPAIIDHLPERHRKFLEDFAFDK ILVKVIQHQESLNINNPQEFINSFLIEMKQEEYNPKIEFAYENLILTASDMFAAGTETS TTLR*SLLLLFKDP*VTAKVQEETDHVIVRHRSPCIQDKNLMPYTNALLHEIQRYLDLLP
T*LYHGKTCCMKFKNCLIYKGIIVIESSTYVLHDDNEFSNPERFDPSHF
CYP2C74X Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP2C8, 78% to CYP2C19, probable ortholog of CYP2C8
renamed CYP2C20. There are only 3 amino acid differences to
Macaca fasicularis (cynomolgus monkey) GenEMBL S53046
Since this is the clear ortholog of that earlier sequence
the name has been changed to reflect the orthology.
CYP2C75 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
93% to CYP2C9, 92% to CYP2C19, possible ortholog of CYP2C9
94% to 2C43
CYP2C75 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2C9v3
2 amino acid differences to 2C75 of Macaca mulatta
93% to 2C9 human, 93% to 2C43, 76% to 2C20 Macaca fasicularis
CYP2C76 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name Novel_mfCYP2C
72% to 2C18 human, 71% to 2C43, 69% to 2C20 Macaca fasicularis,
71% to 2C75 Macaca mulatta, 69% to 2C74 Macaca mulatta
CYP2C76 Callithrix jacchus (white-tufted-ear marmoset)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
83 aa 100% to CYP2C76 Macaca fasicularis
covers I-helix region
CYP2C76 Cercopithecus aethiops (African green monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
N-term 168 aa 100% to CYP2C76 Macaca fasicularis
CYP2C76 Macaca mulatta (rhesus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
98% to CYP2C76 Macaca fasicularis
complete sequence
CYP2C77 rat
variant of 2C6 13 aa diffs to CYP2C6v1_v1, 16 aa diffs to 2C6v2
This gene has three frameshifts
244357850 MDLVMLLVLTLTCLILLSIWRQSSGRGKLPPGPIPLPIIGNIFQLNVKNITQSLTS (0) 244358017
244359760 FSKVYGPVFTLYFGMKPTVILHGYEAVKEALIDHGEEFAERGSFPVAEKINKDL (1) 244359921
244360096 GIIFSHGNRWKEIRRFTLTTLRNLGMGKRNIEDRVQEEARCLVEE 244360230
244360232 MRKTN 244360246
244361085 GSPCDPTFILGCAPCNVICSIIFQNRFDYKDQDFLNLMEKLNENMKILSSPWTQ 244361246
244362321 FCSFFPVLIDYCPGSHTTLAKNVYHIRNYL 244362410
244362412 LKKIKEHQESLDVTNPQDFIDYYLIKWKQ 244362498
244381928 ESHNPHSEFTLENLSITVTDLFGAGTETTSTTLRYALLLLLKYPEIT 244382068
244392235 AKVQEEIDRVFGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPTNLPHAVTCDIKFRNYLIPM 244392423
244394012 GTTIITSLSSVLHDSKEFPNPEIFDPGHFLDGNGKFKKSDYFMPFSA 244394152
244395307 GKRMFAGEGLA 244395339
244395341 RMELFLFLTTILQNFKLKSVLQPKDIDTTPVFHGFASLPPFYELCFIPL 244395487
rat 2C cluster in chromosome order
CYP2C77-de1b2b3b4b5b rat
frag c Pseudogene 96% to 2C6_v1 exons 1-5 with partial deletion of exon 3 Plus Strand
244337898 MDLVMLLVLTLSCLILLSIWSQSSGRGKLP 244337987
244337987 SGPTPLPIIGNFFHLDLKNITQSLTS 244338064
244339793 FSKVNGSVFTLYFGMKPIVILHGYEAIK*GLIDHREEFTERGSFPVAEKINKGL 244339954
244340129 GIAFSHGNRWKEIRRFTLMTLQNLGMGK 244340212
244341157 GSPCDPTFILGCAPCNVICSIIFQNSFDYKDQDFLSLMEKLNENIKIVSSPWI* 244341318
244342872 FCSSFPVFIDYCPGIHMTLA 244342931
244342933 KNVYHTRNYILKKIKEHQESLDVTNPHDFIDYYLIKWKQ 244343049
rat 2C cluster in chromosome order
CYP2C78 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
58-60% to all four CYP2Cs in human
CYP2C79 rat
GenEMBL XM_219933
minus strand 72% to 2C6_v1 95% to seq e, 100% to seq q (exon 9),
93% to seq z (exon 5) (temp name = CYP2CNEWD)
244590183 MILGVFLGLFLTCLLLLSLWKQNFQRRNLPPGPTPLPIIGNILQIDLKDISKSLRN 244590016
244575990 FSKVYGPVFTLYFGRKPAVVLHGYEAVKEALIDHGEEFAGRGIFPVAEKFNKNC 244575829
244575612 GVVFSSGRTWKEMRRFSLMTLRNFGMGKRSIEDRVQEEARCLVDELRKTN 244575463
244553851 GVPCDPTFILGCAPCNVICSIVFQNRFDYKDQEFLALIDILNENVEILSSPWIQ 244553690
244525726 ICNNFPAIIDYLPGRHRKLLKNFAFAKHYFLAKVIQHQESLDINNPRDFIDCFLIKMEQ 244525550
244524359 EKHNPKTEFTCENLIFTASDLFAAGTETTSTTLRYSLLLLLKYPEVT 244524219
244517844 AKVQEEIDHVIGRHRSPCMQDRHHMPYTDAVLHEIQRYIDLLPTSLPHALTCDMKFRDYFIPK 244517656
244516177 GTTVIASLTSVLYDDKEFPNPEKFDPSHFLDENGKVKKSDYFFPFST 244516037
244496745 GKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKELDTNPVANGFVSVPPKFQICFIPI 244496566
rat 2C cluster in chromosome order
CYP2C79-de9b rat
exon 9 62% to 2C79 2 aa diffs to seq d and seq p
244491372 G*WICVREDLAQMTLFLFCPTILKNFNLNSQVNPKEL 244491262
rat 2C cluster in chromosome order
CYP2C79-se1[9] rat
frag q Exon 9 100% to 2C79
243885148 GKRICVGEGLARTELFLFLTTILQNFNLKSPVDLKELDTNPVANGFVSVPPKFQICFIPI* 243885330
CYP2C80 rat
GenEMBL XM_217906.2 GNOMON exon 2 on AC109577.4 in HTGS
92% to 2C24, 73% to 2C11 (temp name = CYP2CNEWC)
MGWLSDP wrong N-term from GNOMON prediction
Correct N-term possibly in a sequence gap
244632544 FSEVYGPVFTLYFGLKPTVVVYGYEVVKEVLDGEEFSGRGVFPIVTKVNNDL 244632389
this exon 2 does not match 2C24
244632205 GVIFSNGTKWKELRRFSLMTLRNFGMGKRSIEDRIQEEASCLVEELRKTN 244632056
244628281 GSLCDPTFILSCAPSNVICSVIFHNRFDYKDENFLNLMEKFNENFKILNSPWMQ 244628120
244624041 VCNAIPAFIDYLPGSHNKVIKNFAEIKSYILRRVKEHQETLDMDNPRDFIDCFLIKIE 244623868
244620080 QEKHNPCTEFTIQSLVATVTDVFVAGSETTSTTLRYGLLLLLKHTEVT 244619937
244619006 AKVQEEIDHVIGRHRRPCMQDRTRMPYTDAMVHEIQRYINLIPNNVPHAATCNVRFRNYVIPK 244618818
244616897 GTDLITSLTSVLHDDKEFPNPEVFDPGHFLDEHGNFKRSDYFMPFSS 244616757
244614348 GKRMCVGEALARMELFLLLTTIVQNFNLKSFVATKDIDTTPLTNTFGCVPPSYQLYFTPR* 244614166
rat 2C cluster in chromosome order
CYP2C81 rat
93% to 2C7 28 aa diffs missing exon 1 Plus Strand, 91% to seq j (exons 6,7)
93% to seq k (exons 2,3)
244672079 FSKTYGPVFTLYLGSQPTVILHGYEAIKKALIDHGEKFSGRGSYPMIENVTKGF 244672240
244672408 GIAFSNGNRWKEIRRFTIMTLRNLGMGKRNIEDRVQEEAQRLVEELRKTK 244672557
244681144 GSPCDPSFILNCAPCNVICSITFQNHFDYKDKEILTFMEKVNENVKIMSSPRMQ 244681305
244683123 VCNSFPSLIDYFPGTHHKIAKNINYMKSYLLKKIEEHQESLDVTNPRDFVEYYLIKQKQ 244683299
244699290 ANHIEQSEYSHENLACSIMDLIGAGTETMSSTLRYALLLLMKYPHVP 244699430
244713313 AKVQEEIDHVIGRYRSPCMQDRSHMPYTDAMIHEVQRFINFVPTNLLHAVTCDIKFRNYLIPK 244713501
244717457 GTKVLTSLTSVLHGSKEFPNPEMFDPGHFLDENGNFKKSDYFLPFSA 244717597
244718606 GKRACVGEGLARMELFLFLTTILQNFKLKSLVHPKDIDTRPVLNGFASLPPTYQFCFIPS 244718785
rat 2C cluster in chromosome order
CYP2C81-de7b rat
frag a Exon 7 minus Strand 100% to seq r, 80% to 2C13
244724629 LRVQEEIDQVIGRNPSPCMQDRSHMPYTNAMVHEVQR*SNIVPNNIVYEVTCDTKFRNYFIPK 244724441
CYP2C81-de8b rat
frag 1 Exon 8 93% to 2C7 Plus Strand
244737232 GTTVLTSLTSVLHDSKEFPNPEMFDPGHFLDENRNFKKSDYFMPFSA 244737372
CYP2C81-de8c rat
frag 2 Exon 8 76% to 2C13 Plus Strand 87% to seq u
244764239 GMMVITSLSSVLHYNKEFPNPERFDPGYFLDGNGNFKKTDYFILFSA 244764379
CYP2C81-de1d rat
frag 3 Exon 1 with frameshift Plus Strand 85% to seq e 83% TO SEQ w
244783632 MDLVVVL 244783652
244783654 CSVSSLLLFSLWRQSSWRRKLPPGPNPLPIIGNFLQIDLNNLCQSLNN (0) 244783797
CYP2C81-de6e7e rat
frag 4 exon 6 70% to 2C13 Plus Strand
244799349 ELELEHLGSMVTDLFFAGIESIRTTMIFALLFLLNTHTSQ 244799468
exon 7 82% to 2C13, 86% to seq r and seq a
244801583 LQNRSHMPYTNAMVHEVQRYSDIVPNNIVHEVTSDTKFRNYFIPK (0) 244801717
CYP2C81-de1f2f3f rat
frag 5 Exons 1,2,3 84% to 2C7 variant Minus Strand
244826982 MDLVTFLVLTLSSLILLSLWR*NSRRRKLPPGPTPLLIIGNFLQLDVKNVSQSLTM (0) 244826815
244813456 FSKAYGPVFTLYLGSQPTVILHGYEAVKETLIDHGEEFSGRGSFPMVEKAFKCF 244813295
244813129 GIVFSNGNR*KEIRQFIIMTLQNLGMGKRNIEDHVQEEAQCLVEELRKTK 244812980
CYP2C82P rat
frag e Exons 1,4,4,5,6,7,8,9 almost an exact duplicate of seqs w,x,y,z,
exons 6-9 of the wxyz cluster in a seq gap
244218695 MDPVVVLMPSFSSLLLLSLWRQNSWRRKLPPGPNPLPIIGSFLQIDLNDLCQSLINE (0) 244218865
244233879 LILSYASCNVICSITFQNRFDYKDKEILTLMEKVNENVKIMSSPWIQ 244234019
244240189 GVPCDPTFILGCAPCNVICSIVFQNHFNYKGQEFLALIDTLNENVEILSSPWIQ 244240350
244265531 ICNNFPAIIDYLPGRHRKLLKKFAFAKHYFLAKVIQHKESLDINNPRDFIDCFLIKMEQ 244265707
244266904 KHNPKTEFTCKNLIFTASDLFAAGTETTSPTLRYSLLLLPKYPEV 244267038
244273480 AKVQEEIDHVIGRHRSPCMQDRHHMPYTDAVLHEIQ*YIDLLPTSLPHALTCDMKFRDYFIPK 244273668
244275197 GTTVIASLTSVLYDDKEFPNPEKFDLSHFLDENGKFKKSDYFFPFST 244275337
244286429 GKRICVGEGLAQTELFLFLTTILQNFNLKSPVDLKELDTNPVANGFVSVPPKFQICFIP 244286605
>CYP2C82P-de9b frag d Exon 9 identical to seq p
244289962 GKWICVREDLAQMTLFLFCPTILKNFNLKSQVNPKEL 244290072
rat 2C cluster in chromosome order
>CYP2C82P-se[1:4:4:5] rat
frag z Exon 5 minus strand 1 aa diff to CYP2C82P
243632036 ICDNFPAIIDYLPGRHRKLLKKFAFAKHYFLAKVIQHKESLDINNPRDFIDCFLIKMEQ (0) 243631860
frag y Exon 4 minus strand 92% to CYP2C82P
243654367 GVPCDPTFILGCAPCNVICSIVFQNHFNYKDQEFLALIE 243654251
243654249 LNENVEILSSP*IQ 243654208
frag x exon 4 minus strand 100% to CYP2C82P short exon 4
243659542 LILSYASCNVICSITFQNRFDYKDKEILTLMEKVNENVKIMSSPWIQ 243659402
frag w Exon 1 minus strand 100% to CYP2C82P
243675609 MDPVVVLMPSFSSLLLLSLWRQNSWRRKLPPGPNPLPIIGSFLQIDLNDLCQSLIN 243675442
rat 2C cluster in chromosome order
CYP2C83 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP2C9, 90% to human CYP2C19
cannot tell if this is the ortholog of
2C9 or 2C19 without map information
98% to 2C43 probable ortholog, name may be changed to 2C43
CYP2C84 Phalacrocorax carbo (Common cormorant)
No accession number
Hisato Iwata
submitted to nomenclature committee 5/19/05
81% to 2C45 chicken (possible ortholog), 56% to 2C11 rat
CYP2C85 Bos taurus (cow)
See cattle page for details
MDLPVVLVLCLCCLLLISLWKQSSGKGKLPPGPTPLPILGNILQLDVKDISKSVSN
LSKVYGPVFTLYFGMNPLVVLHGYEAVKEALIGLGEEFSGRGSCPVIQRASKGY
GVIFSNGKIWKETRRFSLMTLRDFGMGKRSMEDRVQQEACCLVEELRKTD
GLPCDPTFILGCAPCNVICSIIFQNHFDYKDQIFLDLMERLNENARILGSPWIQ
LCSSFPALIDYVPGKHKKFFENYACMKSYVLEKTREHQASLDMNNPRDFIDCFLTKMEQ
EKHNQELEYTVENLAHTVLDLFVAGTETTSTTLRYGLLLLLKHPEVT
AKVQEEIDHVIGRHRSPCMQDKSHMPYTDAVVHEIQRYIDLVPTNLPHAVTCDIKFRNYLIPK
GTGILTSLTSVLYDDKEFPNPEVFDPGHFLDESGNFRKSDHFMAFST
GKRICVGEGLARMELFLFLTTILQNFTLKSVVDPKDLDTTPVVNGLLSVPPFYQLCFIPV*
CYP2C86 Bos taurus (cow)
See cattle page for details
MERLEITTLALVICVTCLVFLFVWKKSHKGLGKLPPGPTPLPIIGNLMQLNLKDIPASLSK
LAKQYGPVYTLHLGSQTTVVLHGYEVVKEALIDQGDEFLGRAHFPIIDDTQRGY
GLIFSNGDTWKQMRRFSSLMTLRDFGMGKRSLEERIQEEAQFLVEEFRKSE
AQPFNPAVTLSCATCNIICSILFNERFHYQDKTLHSLLDLLNENFNRISSLWNQ
IYNLWPKLIKPLPGEHRAFSKRLKDVHYFVLEKVKEHQKSLNHNNPRDYIDCFLSRMEQ
EKQNPESQFHLENLATCGSNLFSAGVETTTATLSYGFLLLMKYPEVQ
AKVHEEIDRVIGRTRSPCMKDKMKLPYTEAVLHEIQRYVTLVPSNLPHAVVQDTKFRQYVIPK
GTTVLPLLSSILYDCKEFPNPEKFDPGHFLDKNGSFRKTKYFVAFSI
GKRACVGEGLAQMELFLFFTTILQNFVLKPLGETKDIETKPIVIGLINMPPPFKLCLIPR*
CYP2C87 Bos taurus (cow)
See cattle page for details
MDLAVVLVLCLSCLLLLSLWKQSSGKGKLPPGPTPLPILGNIFQLDVKNISKSLTS
LSKVYGPVFTVYFGMKPTVVLHGYEAVKEALIDLGEEFSRRGSFPVIERNVKGH
GIVFSNGKTWKETRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTN
GLPCDPTFILGCAPCNVICSIIFQNRFDYKDQTFLNLMKTINENIKILGSPWIQ
VLNIFPVLLDFFPWSYSYKKLYTNTAYVKNYVLEKTREHQASLDINNPRDFIDCFLIKMEQ EKHNHQSEYTFENLTITVSDLFGAGTETTSTTLRYGLLLLLKHPEVT
AKIQEEIDRVIGRHRSPCMQDRTHMPYMDAVLHEIQRYIDLAPTSVPHAVNCDVKFRNYLIPK
GTDILTSLTSVLHDDKEFPNPEVFDPGHFLDENGNFRKSDYFMAFSAGKRVCVGEGLA
RMELFLFLTTILQTFTLKSVVDPKDLDTTPAVTGIANVPPPYQLCFIPV*
CYP2C87-de2b Bos taurus (cow)
6kb downstream of 2C87 without an intervening exon 1, same orientation
LSKVCGPVFTVYFGMKPTVVLHGYEALQEALIDLGEEFSGRYSFPVNEKTRRGH
CYP2C88 Bos taurus (cow)
See cattle page for details
MDLAVVLVLCLSCLLLLSLWKQSSGKGKLPPGPTPLPILGNILQLDVKNISKSLTN
LSKVYGPVFTVYFGMKPIVVLHGYEAVKEALIDLGEEFSGRGMFPLAERANIVN
GILFSNGKTWKEIRRFSLMTLRNFGMGKRSIEDRVQEEACCLVEELRKTN
GLPCDPTFILGCAPCNVICSIIFQNRFDYKDPVFLDLMERLNEILRILSSPWVQ
VCNNFPALFDYLPGSHNKVLKNVANLKSFVLEKAMEHKASLDINNPRDYIDCFLIRMEQ
EKQNQQLEFTLENLTTTVFDLFGAGTETMSTTLRYGLLLLLKHPEVT
AKVQEEIDRVIGRHRSPCMQDRSHMPYTDAVVHEIQRYIDLVPSSLPHMVTHDIELRNYIIPK
GTGVLVSLTSVLYDDKVFPNPEMFDPGHFLDDSGNFKKSDHFMPFSA
GKRICAGESLARMEVFLFLTVILQKFTLKSVVDPKDIDTTPIANGFASVPPPYKLCFIPL
CYP2C89 Bos taurus (cow)
See cattle page for details
XXXXXGPVFTLYFGMKPTVVLHGYEAVKQVLIDQSEEFSGRGSLPVADNINQGL
GIVFSNGEIWKQTRRFSLMVLRNMGMGKRTIEHRIQEEALCLVEALKKTN
GSPCDPTLLLSCAPCNVICSIIFRNRFEYNDERLLTLIKYFNENSRLVSTPWVE
LYNTFPSLLHYFPGSHNTIFKNMTEQRKFILEEIKKHQESLDLNNPQDFIDYFLIKMEK
EKHNKHSEFTMDNLITTVWDVFSAGTETTSLTLRYGLLLLLKHPEVT
AKVQEEIDRVVGRNRSPCMQDKSCMPYTDAVLHEIQRYIDLVPSSMPHAATQDVKFREYLIPK
GTVILTSLTSVLHDDNEFSNPGQFDPGHFLDESGNFKKTDHFMAFSA
GKRVCVGEGLARMELFLLLVSILQHFTLKSVVDPKHIDTAPSFKGLISIPPFCEMCFIPV* 1292
CYP2C90 Bos taurus (cow)
See cattle page for details
LSNTYGPVFTVYFGLRPTVVLHGYEAVKEALIDQGEEFSGRGNIPMSQRVNKGY
GIIFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAHCLVEELRKTN
GSPCDPTFILGCAPCNVICSIIFQNRFDYTDQNFLNLLDKFNENLQVVSSPWMQ
VCNTFPILIDYFPGSHNKLFKNFAYIRSYVLEKVKEHQATLDINNPRDFIDCFLIKMEQ
EKHNQEMEFTFENLIASVSDLFGAGTETTSTTLRYGLLMLLKHPEVT
AKVQEEIDRVIGRHRSPCMQDRSHMPYMDAVVHEIQRYIDLVPTNLPHAVTRDIKFRNYLIPK
GTTVVTSLSSVLHDEKEFPNPKVFDPAHFLDESGNFKKSDYFMAFSA
GKRSCVGEGLARMELFLFLTTILQKFTLKSVVDPKDLDTTPVSSGFGHVPPPYQLCFTPL*
CYP2C91 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
Partial seq. differs from known pig sequences 66% to 2C36
frameshift and small deletion
pseudogene?
CYP2C92 horse
No accession number
Heather Knych
Submitted to nomenclature committee June 25, 2007
83% to CYP2C87 cow, 81% to CYP2C49 pig
CYP2C-se1[7] human
NT_022154.9|Hs2_22310
2C pseudogene fragment chr 2
old CYP2C56P
Chr2q24.3 165142570-165142755 + strand Build 33
1768955 SKVQEETDHAVGRHWRPCMQDRSHMPYTEAMVHEVQRH*PHPTNVPHALTSDIKFRNYLLPK 1769140
CYP2C-se2[1:2] human
NT_008583.11|Hs10_8740
Chr10q21.3 66415290-66415135 - strand, Build 33 in MER1_type repeat
chromosome 10 pseudogene frag parts of exons 1 and 2
old name = CYP2C61P
1832658 KGKLPHDLTSFLFVGNILQLNSKNLSKSITMLAKDYGPGFTVYFGIKPTVVV 1832813
CYP2C-se3[1] human
NT_011512.5|Hs21_11669
chromosome 21 51% to 2C9
chr21q21.2 25740563-25740423 build 33 - strand bracketed by L1 repeats
old name = CYP2C63P
12398358 CPSCLILLFLWNGSYAKGKLLPGPIPLPIV*NILPLRSMNTSKSISMVS 12398212
CYP2C-se4[1] human
NT_011602.7|HsX_11759
2C pseudogene fragment chr X 57% to 2C8
ChrXq28 147659303-147659476 + strand Build 33
inside MTMR1 intron 3 (myotubularin-related protein 1)
old name = CYP2C64P
435396 ASVDLAAVLVLFLSHFLFLSLWKQSSEREKLLPGPTPIRIIGNILELDLKDICKSLSDVN 435575
435576 MLYAPL 435593
Cyp2c-se5[9] mouse
GenEMBL NW_000107.1|Mm16_WIFeb01_286
2c exon 9 fragment on chr 16
42687727 PFSTGKLICVGEGLARAELLLLLTTILQNFNLKSPVDLKDLDTIPVANG 42687873
CYP2C-se6[9] rat
frag p exon 9 100% to CYP2C82P-de9b
243895387 GKWICVREDLAQMTLFLFCPTILKNFNLKSQVNPKEL 243895497
CYP2C rat
no accession number (639bp)
Zaphiropoulos,P.
submitted to nomenclature committee
82% amino acid identity to exon 2 of 2C24
CYP2C rat
no accession number (397bp)
Zaphiropoulos,P.
submitted to nomenclature committee
similar to exon 3 of 2C7
possible pseudogene, with stop codon at location of conserved trp.
CYP2C rat
PIR B60822 (19 amino acids)
Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
Oesch, F.
Effect of nutritional imbalances on cytochrome P-450 isozymes
in rat liver.
Biochem. Pharmacol. 37, 3245-3249 (1988)
CYP2C dog
PIR A60465 (33 amino acids)
Komori, M., Shimada, H., Miura, T. and Kamataki, T.
Interspecies homology of liver microsomal cytochrome P-450. A
form of dog cytochrome P-450 (P-450-D1) crossreactive with
antibodies to rat P-450-male.
Biochem. Pharmacol. 38, 235-240 (1989)
Note: probable N-terminal of 2C21 which is missing the N-terminal region
CYP2C horse
PIR PN0659 (16 amino acids)
Komori, M., Higami, A., Imai, Y., Imaoka, S. and Funae, Y.
Purification and characterization of a form of P450 from
horse liver microsomes.
J. Biochem. 114, 445-448 (1993)
2D Subfamily
CYP2D1 rat
PIR A30495 (19 amino acids)
Gonzalez, F.J., Matsunaga, T., Nagata, K., Meyer, U.A.,
Nebert, D.W., Pastewka, J., Kozak, C.A., Gillette, J.,
Gelboin, H.V. and Hardwick, J.P.
Debrisoquine 4-hydroxylase: characterization of a new P450
gene subfamily, regulation, chromosomal mapping, and
molecular analysis of the DA rat polymorphism.
DNA 6, 149-161 (1987)
CYP2D1 rat
PIR S39761 (13 amino acids)
Ohishi, N., Imaoka, S., Suzuki, T. and Funae, Y.
Characterization of two P-450 isozymes placed in the rat
CYP2D subfamily.
Biochim. Biophys. Acta 1158, 227-236 (1993)
CYP2D1 rat
GenEMBL J02867
chr7: 120808284-120803991 (- strand)
MELLNGTGLWSMAIFTVIFILLVDLMHRRHRWTSRYPPGPVPWPVLGNLLQVDLSNMPYS
LYKLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTA
DRPPVPIFKCLGVKPRSQGVILASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEA
GHLCDAFTAQAGQSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTE
VSGFIPEVLNTFPALLRIPGLADKVFQGQKTFMALLDNLLAENRTTWDPAQPPRNLTD
AFLAEVEKAKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRV
QQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRFTSCDIEVQDFVI
PKGTTLIINLSSVLKDETVWEKPHRFHPEHFLDAQGNFVKHEAFMPFSA
GRRACLGEPLARMELFLFFTCLLQRFSFSVPVGQPRPSTHGFFAFPVAPLPYQLCAVVREQGL
CYP2D2 rat
GenEMBL X52027 X52455
chr7: 120834409-120830514 (- strand)
MGLLIGDDLWAVVIFTAIFLLLVDLVHRHKFWTAHYPPGPVPLPGLGNLLQVDFENMPYS
LYKLRSRYGDVFSLQIAWKPVVVINGLKAVRELLVTYGEDTA
DRPLLPIYNHLGYGNKSKGVVLAPYGPEWREQRRFSVSTLRDFGVGKKSLEQWVTEEA
GHLCDTFAKEAEHPFNPSILLSKAVSNVIASLVYARRFEYEDPFFNRMLKTLKESFGE
DTGFMAEVLNAIPILLQIPGLPGKVFPKLNSFIALVDKMLIEHKKSWDPAQPPRDMTD
AFLAEMQKAKGNPESSFNDENLRLVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRV
HEEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADIVPTNIPHMTSRDIKFQGFLI
PKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSA
GRRACLGEPLARMELFLFFTCLLQRFSFSVLAGRPRPSTHGVYALPVTPQPYQLCAVAR
CYP2D3 rat
GenEMBL X52028
Chr7: 120817315-120813086 (- strand)
MELLAGTGLWPMAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLCNMPYS
MYKLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTA
DRPEMPIFQHIGYGHKAKGVVLCTYGPEWREQRRFSVSTLRNFGVGKKSLEQWVTDEA
SHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKESMGE
QTGLFPEVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTEHKKTWDPDQPPRDLTD
AFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRV
QQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLI
PKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSA
GRRACLGEPLARMELFLFFTCLLQRFSFSVPTGQPRPSDYGVFAFLLSPSPYQLCAFKR
CYP2D3-de8b rat
UCSC browser Chr 7 (+ strand) 120811066-120811206
2aa diff to 2D2/2D3 exon 8
lies between 2D1 and 2D3, a in fig. below
GTTLIPNLSSLLNDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSA
rat, mouse and human 2D clusters
CYP2D4_v1 rat
GenEMBL M22331.1 X52029
ONLY 5 AA DIFFS to CYP2D4_v2
120781146-120776576 (- strand)
note: 2D18 is an alternate splice of an untranslated exon of
the 2D4 gene. The 5 aa diffs are allelic variation
both haplotypes are found in the same library
see Supporting document
MRMPTGSELWPIAIFTIIFLLLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQIDFQNMPAGFQK ()
LRCRFGDLFSLQLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQ ()
GVVLARYGPAWRQQRRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHS ()
GFPFSPNTLLDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGFLPM ()
LLNVFPMLLHIPGLLGKVFSGKKAFVAMLDELLTEHKVTWDPAQPPRDLTDAFLAEVEK ()
AKGNPESSFNDENLRVVVADLFMAGMVTTSTTLTWALLFMILRPDVQC ()
RVQQEIDEVIGQVRRPEMADQARMPFTNAVIHEVQRFADILPLGVPHKTSRDIEVQGFLIPK ()
GTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSA ()
GRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSNYGVFGALTTPRPYQLCASPR
CYP2D4_v2 rat
GenEMBL U48219 S77859
ONLY 5 AA DIFFS to CYP2D4_v1
120781146-120776576 (- strand)
note: 2D18 is an alternate splice of an untranslated exon of
the 2D4 gene. The 5 aa diffs are allelic variation
both haplotypes are found in the same library
see Supporting document
CYP2D5 rat
GenEMBL X52030 X52458
chr7: 120799154-120794726 (- strand)
MELLNGTGLWPMAIFTVIFILLVDLMHRHQRWTSRYPPGPVPWPVLGNLLQVDPSNMPYSMYK
LQHRYGDVFSLQMGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGVKPRSQ
GVVFASYGPEWREQRRFSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTAQN
GRSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMLTLVEESLIEVSGFIPE
VLNTFPALLRIPGLADKVFQGQKTFMAFLDNLLAENRTTWDPAQPPRNLTDAFLAEVEK
AKGNPESSFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQR
RVQQEIDEVIGQVRCPEMTDQAHMPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPK
GTTLIINLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSA
GRRACLGEPLARMELFLFFTCLLQHFSFSVPAGQPRPSTLGNFAISVAPLPYQLCAAVREQGH
CYP2D6 human
GenEMBL M24499 (1195bp)
Manns,M.P., Johnson,E.F., Griffin,K.J., Tan,E.M. and Sullivan,K.F.
Major antigen of liver kidney microsomal autoantibodies in
idiopathic autoimmune hepatitis is cytochrome P450db1
J. Clin. Invest. 83, 1066-1072 (1989)
CYP2D6 human
GenEMBL A20907 (1768bp)
Genetic assay for cytochrome p450
Patent: WO 9110745-A 13 25-JUL-1991;
CYP2D6 human
GenEMBL M33189 (5503bp)
Gonzalez,F.J.
unpublished (1990)
Note on the 2D6 locus. The normal situation is CYP2D8P, CYP2D7P, CYP2D6
Alleles with an extra pseudogene have been found
CYP2D8P, CYP2D7AP, CYP2D7BP, CYP2D6
Heim,M.H. and Meyer,U.A.
Evolution of a highly polymorphic human gene locus for
a drug metabolizing enzyme.
Genomics 14,49-58 (1992)
The 2D7AP sequence is 94.7% identical to CYP2D7P
The 2D7BP sequence is created by gene conversion between
2D7AP and CYP2D6 and it is named CYP2D8BP below.
CYP2D7P human
GenEMBL M33387
The typical human 2D7 pseudogene
In the 1996 nomenclature this was named CYP2D7P1
CYP2D7P1 human
Same as CYP2D7P
CYP2D7P2 human
Same as CYP2D7AP
CYP2D7AP human
GenEMBL X58467 (13,278bp)
Heim,M.H. and Meyer,U.A.
Evolution of a highly polymorphic human gene locus for
a drug metabolizing enzyme.
Genomics 14,49-58 (1992)
Note: CYP2D7AP is 94.7% identical to CYP2D7P, both are
pseudogenes. In the 1996 nomenclature this was named CYP2D7P2
CYP2D7BP human
This is the authors name for CYP2D8BP below
In the 1996 nomenclature this was named CYP2D8P2
CYP2B8P human
GenEMBL M33387
The typical human 2D8 pseudogene
In the 1996 nomenclature this was named CYP2D8P1
CYP2D8P1 human
Same as CYP2D8P
CYP2D8P2 human
Same as CYP2D7BP and CYP2D8BP
CYP2D8BP human
GenEMBL X58468 (13,677bp)
Heim,M.H. and Meyer,U.A.
Evolution of a highly polymorphic human gene locus for
a drug metabolizing enzyme.
Genomics 14,49-58 (1992)
This gene is called CYP2D7BP by the authors
Note: CYP2D8P is a chimeric gene composed of part of
CYP2D7AP and part of CYP2D6. There are only 14 base
changes in 13,677 base pairs relative to these parents.
This gene is different from CYP2D8P. It is a pseudogene.
In the 1996 nomenclature this was named CYP2D8P2
Cyp2d9 mouse
GenEMBL J04471 M24262 (846bp) M24267 (3367bp)
Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
Gene family of male-specific testosterone 16-alpha-hydroxylase
(C-P-450-16-alpha) in mice: Organization, differential regulation,
and chromosome location
J. Biol. Chem. 264, 2920-2927 (1989)
Cyp2d9-de1b2b mouse
GenEMBL NT_039621.1 + strand
x in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
exons 1 and 2 8-10kb upstream of 2d9
43879793 MELLTGTDLWSVAIFTVIFILPVDLLHRRQRWTSRCPPGPVPWPVLGNLLQVDLDNMPYSLYK 79981
43880823 XXNRYGDMFSLHMAWKPMVVINGLKAMKEVLLTCGEDTADSPPVPIYEHRGXXXXXX 80969
Cyp2d9-de1c5c6c7c mouse
GenEMBL NT_039621.1 + strand
y in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
exons 1,5,6,7 between 2b9 and 2b10 (uup)
43869836 MELLTGTELWPVAIITVIFILLVDLMHYHQLWTSHY 69943
43869943 PPGPVLWPVLGNLLQMDLHNMPHSMYK 70023
43872058 VLNTFPILLCIPGWADKVFPG*STFLTMVDKLVTEPKRT*DPDQPPCDLIDAFLAEMXX 72228
43872341 AKGNPSSNFNDANLRLVVFNLFGAGIVTSSITLTWVLLLMVLHPDVQ 72481
43872703 RLHQETDEVIGHVWWPERQSQX 72765
43872768 LMPYTNAVIHEVQHYTGIIPIPLPHRTSSDIEMQDFLITK 72887
Cyp2d9-de1d6d7d mouse
GenEMBL NT_039621.1 - strand
z in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
exons 1,6,7 10kb upstream of Cyp2d9-de1c5c6c7c
43859756 MELLTGTSLWPVAILTVIFILLQDLMHQQKCCTSCYLPGTVLWTLQRNLLQVDLHSMPHSLCK 59568
43858655 AKGNLESSFNDANLSLVVLDQFGTGIVASSVTLTWGLLLTILNPDVQ 58515
43858292 RMQQEIDKVIEHVW*TEMVHQAYMPYTNAAIHEVQRYKDIIPIPLPHRTSSDVEMQDFLITK 58107
Cyp2d10 mouse
GenEMBL J04471 M24263 M24265 M24268 (4828bp)
Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
Gene family of male-specific testosterone 16-alpha-hydroxylase
(C-P-450-16-alpha) in mice: Organization, differential regulation,
and chromosome location
J. Biol. Chem. 264, 2920-2927 (1989)
Cyp2d11 mouse
GenEMBL J04471 M24264 M24266 (5661bp)
Wong,G., Itakura,T., Kawajiri,K., Skow,L. and Negishi,M.
Gene family of male-specific testosterone 16-alpha-hydroxylase
(C-P-450-16-alpha) in mice: Organization, differential regulation,
and chromosome location
J. Biol. Chem. 264, 2920-2927 (1989)
Cyp2d12 mouse
no accession number
Negishi,M.
submitted to nomenclature committee in 1990, but never published.
ESTs AI116003 ue25f10.x1 (295-end 2 diffs, 1fs) AI785325 uj40c11.x1
(326-end 1 diff) AI527869 uj30b05.y1 (1-241 4 diffs, 2fs) AA986388
uc82e10.x1 (307-end 4 diffs)
Public Cyp2d12 from EST sequences. Places where ESTs do not match Negishi's
sequence are shown in (). The EST seq is given. In these sites Y, G, N, A and R
are observed in multiple ESTs and they are probably the correct amino acids
F at the last variable site is seen twice and S is seen twice so this may be a
polymorphic site
MELLTGTDLWSVAIFTVIFILLVDLM (Y) RRQSWTSCYPPGPVPWPVL (G) NLLQVDL (N) NMPYSL
YKLQNRYGDVFSLQMAWKPMVVINRMKAMKEVLLTCGEDTADRPPVPIFEHLGFKPRSQGMIFAPYGPEWREQ
RRFSLSSLRNFGLGRKSLEEWVIKEAGHLCDAFTTQAGQYINPNTMLKK (A) TCNVIASLIFARRFEYED
PYLIRMLKVLEDSLTELSGLIPEVINTFPILLHIPRLAD
(53 amino acid gap)
ENLRMVVIDLFTAGILTTSTTLSWALLLMILHPDVQRRVQQEIDEVIGQVRHPEMADQAHMPYTNAVIHEVQRFGDIVPLHLPRITSRDIEVQDFLIPKGTILLPNMSSVHMDDTVWEKPLRFHPEHFLDAQGHFVKHEAFITFSAG (R) RSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPQPSDHRVF (F) IMVAPSPYQLCAVIREQGH*
Cyp2d12-de1b5b6b7b mouse
GenEMBL NT_039621.1 - strand
detritus exons 1,5,6,7 fragments 7kb upstream of 2d12
v in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
44005713 M*LLTGTGLWPVAIFTIIFILLQDLMHHLKLWTSCYPPGTVPWPL 44005579
44003512 NTLPDSPAHPRVA*QVSPGTMTFLTMMDKLVTEQKRTWDPDHPLCNLTDAFLAEMEK 44003342
44003204 AKGSPQSSFKGANLCLVVLDQFDAGIVTTSITLT*GLLLTILNPRVQ 44003064
44002849 RVQQEINKVIGHV**PEMVDQDHMSYSNAVMYEVQHYADIITIPLAHKTFSDVEVQGSLITK 44002664
Cyp2d12-de5c6c7c mouse
GenEMBL NT_039621.1 - strand
detritus exons 5,6,7
w in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
43998271 PRVA*QVSPGTMTFLTMMDKLVTEHKRTWDPGHPLCNLTDAFLAEMEK 33998128
43997989 AKGSPQSSFKGANLCLVVLDQFDAGIVTASITLTWGLLLTILHPGVQS 33997846
43997629 RVQQEINKVIGHVW*PEMVDQDRMSYSNAVMYEVQRYADIITIPLAHKTFSDVEVQGSLITK 33997444
Cyp2d13 mouse
no accession number
Negishi,M.
submitted to nomenclature committee in 1990, but never published.
no exact matches in the Genbank EST database as of 10/20/97
sequence may be erroneous, or a rare transcript.
Cyp2d13 mouse
No accession number
Brian Libby
partial Cyp2d13 gene sequence
The top half of the sequence below is from Brian Libby
This sequence matches Negishi's except at one amino acid
shown in parentheses. The bottom half is from EST BF533324
Dr. Negishi's sequence called "ce" is complete, but still
unpublished. (see note to Cyp2d26)
Public Cyp2d13 seq from BF533324 EST and Brian Libby. One extra amino acid
seen in EST BF533324 is shown as [D]. Two amino acids that do not agree
are shown in (). The EST sequence is given at the T and G sites.
MELLTGTGLWPVAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYKL
QNRYGDVFSLQMAWKPVVVISGLKAVREVLVTCGEDTADRPEMPIFQHLGYGEKAKGVVF
APYGPEWRELRRFSVSTLRNLGLGKKSLEQWVTEEAGHLCDAFTAQAGSPLDPYTLLNKAVCNV
IASLIYARRFEYGDPDFIKMLKILKENMGENTGLFPE
(15 amino acid gap)
DKVFPGQKTFLTLVNKLVTEHKRTWDP [D] QPPRDLTDAFLAEMEKAKGNPKSSFNEANLRL
VVFDLFGAGIVTSSITLTWALLLMILHPDVQRRVQEEIDEVIGQVRCPEMADQAHMPYTNAVIH
EVQRFADIVPMNLPHKTSHDIEVQGFLIPKGTTLIPNLSS (T) LKDETVWEKPLRFHPEHFL
DAQGHFVKPEAFMPFSAGRRACLGEPL (G) RMELFLFFTCLLQRFSFLVPAGQPQPSDYGIF
TFLVSPSPYQLCAFTRDQATN*
Cyp2d13 mouse
GenEMBL AC087902.4, EST BF533324, NT_039621.1
NT_039621.1 - strand
44100884 MELLTGTGLWPVAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSLYK 44100696
44099867 LQNRYGDVFSLQMAWKPVVVISGLKAVREVLVTCGEDTADRPEMPIFQHLGYGEKAK 44099697
44099412 GVVFAPYGPEWRELRRFSVSTLRNLGLGKKSLEQWVTEEAGHLCDAFTAQAG 44099257
44099169 SPLDPYTLLNKAVCNVIASLIYARRFEYGDPDFIKMLKILKENMGENTGLFPE 44099017
44098352 VLNTFPILLHIPGLADKVFPGQKTFLTLVNKLVTEHKRTWDPDQPPRDLTDAFLAEMEK 44098176
44098036 AKGNPKSSFNEANLRLVVFDLFGAGIVTSSITLTWALLLMILHPDVQ 44097896
44097675 RRVQEEIDEVIGQVRCPEMADQAHMPYTNAVIHEVQRFADIVPMNLPHKTSHDI 44097514
44097515 LEVQGFLIPK 44097486
44097091 GTTLIPNLSSALKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAG 44096948
44095907 RRACLGEPLARMELFLFFTCLLQRFSFLVPAGQPQPSDYGIFTFLVSPSPYQLCAFTR* 44095731
CYP2D14 bovine
GenEMBL S45538 X68013 (1538bp) Swiss Q01361 (487 amino acids)
PIR S29295 S37284 (500 amino acids) PIR S29862 (500 amino acids)
Tsuneoka,Y., Matsuo,Y., Higuchi,R. and Ichikawa,Y.
Characterization of the cytochrome P-450IID subfamily in
bovine liver. Nuceotide sequences and microheterogeneity.
Eur. J. Biochem. 208, 739-746 (1992).
CYP2D14 Bos taurus (cow)
See cattle page for details
MGLLSGDTLGPLAVALLIFLLLLDLMHRRSRWAPRYPPGPTPLPVLGNLLQVDFEDPRPSFNQ
LRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPPAVYEHLGYGPRAEG
VILARYGDAWREQRRFSLTTLRNFGLGKKSLEQWVTEEASCLCAAFADQA
GRPFSPMDLLNKAVSNVIASLTFGCRFEYNDPRIIKLLDLTEDGLKEEFNLVRKV
VEAVPVLLSIPGLAARVFPAQKAFMALIDELIAEQKMTRDPTQPPRHLTDAFLDEVKE
AKGNPESSFNDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQR
RVQQEIDEVIGQVRRPEMGDQALMPFTVAVVHEVQRFADIVPLGLPHMTSRDIEVQGFHIPK
GTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVKQEAFIPFSA
GRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSEHGVFAFLVTPAPYQLCAVPR*
CYP2D15 dog
GenEMBL D17397 (1665bp)
Sakamoto,K., Kirita,S., (Aoyama,J., Baba,T. and Matsubara,T.)
cDNA cloning and characterization of dog P-450 2D.
Arch. Biochem. Biophys. 319, 372-382 (1995)
check authors on paper
MGLLTGDTLGPLAVAVAIFLLLVDLMHRRRRWATRYPPGPTPVP
MVGNLLQMDFQEPICYFSQLQGRFGNVFSLELAWTPVVVLNGLEAVREALVHRSEDTA
DRPPMPIYDHLGLGPESQGLFLARYGRAWREQRRFSLSTLRNFGLGRKSLEQWVTEEA
SCLCAAFAEQAGRPFGPGALLNKAVSNVISSLTYGRRFEYDDPRLLQLLELTQQALKQ
DSGFLREALNSIPVLLHIPGLASKVFSAQKAIITLTNEMIQEHRKTRDPTQPPRHLID
AFVDEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITLTWALLLMILHPDVQRRV
QQEIDEVIGREQLPEMGDQTRMPFTVAVIHEVQRFGDIVPLGVPHMTSRDTEVQGFLI
PKGTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFSAGRRVCLGEP
LARMELFLFFTCLLQRFSFSVPAGQPRPSDHGVFTFLKVPAPFQLCVEPR
CYP2D15 dog
AB004268
Tasaki,T., Ito,S., Kamataki,T. and Fujita,S.
unpublished
CYP2D15 Canis familiaris (dog)
NW_876251.1:6772718-6776665
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
the dog genome has a seq gap between exons 3 and 4
with poor quality seq there. The C-terminal is also missing,
trust the mRNA seq for this CYP.
CYP2D16 guinea pig
GenEMBL U21486 (1666bp)(500 amino acids)
Jiang,Q. Voigt,J.M. and Colby,H.
Molecular Cloning and sequencing of a guinea pig cytochrome P4502D
(CYP2D16): high level expression in adrenal microsomes.
Biochem. Biophys. Res. Commun. 209, 1149-1156 (1995)
CYP2D17 Macaca fasicularis ( cynomolgus monkey)
GenEMBL U38218(1494bp)
Laddison,K.J., Speirs,A., Mankowski,D.C., Tweedie,D. and Lawton,M.
Cloning, Sequencing and expression of the cynomolgus monkey liver
cytochrome P450 that is orthologous to human CYP2D6.
ISSX abstracts number 367 (1995)
94% identity to human 2D6
CYP2D17 Macaca fasicularis (cynomolgus monkey)
GenEMBL ESTs BB889442, BB891868, BB878205,
BB889386, BB890418, BB890246, BB882021, BB881437
L388 polymorphic with F
Three aa differ from U38218 (I297 = M in U38218,
N337 = D in U38218, R426 = H in U38218)
MELDALVPLAVTVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG
NLLHVDFKNTPYCFDQLRRRFGNVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRP
PVPINQVLGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL
CAAFTDQAGRPFRPNSLLDKAVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESG
FLREVLNAIPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL
AEMEKAKGNPESSFNEENLRI VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE
IDN VIGQVRRPEMGDQARMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIELQGFL IPKG
TTLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGR FVKPEAFLPFSAGRRACLGEPLAR
MELFLFFTCLLQRFSFSVPAGQPRPSHHGVFAFLVTPSPYELCAVPR
CYP2D17 Macaca mulatta (Rhesus monkey)
GenEMBL DR774034.1
N-term EST
MELDALVPLAVTVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ
LRHRFGDVFSLQLAWTPVVVLNGLAAAREALVTCGEDTADRPPVPINQVLGFGPRSQGVFLAR
CYP2D17 Macaca nemestrina (pig-tailed macaque)
GenEMBL CO774286.1
only 3 aa diffs with 2D17 M. fasicularis
MELDALVPLAVTVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFKNTPYCFDQ
LRRRFGNVFSLQLAWTPVVVLNGLAAVREALVTCGEDTADRPPVPINQVLGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFTDQAGRPFRPNSLLDK
AVSNVIASLTYGRRFEYDDPRFLRLFDLTHEALKEESGFLREVLNAIPLLLRIPGLAGKV
LRSQKVFLTQLDELLTEHRMTWDPXXPPRDLTEAFLGKMEKAKGNPE
CYP2D18X rat
GenEMBL U48219, S77859
Kawashima,H. and Strobel,H.W.
cDNA cloning of a novel rat brain cytochrome P450 belonging to the
CYP2D subfamily.
Biochem Biophys Res. Commun. 209, 535-540 (1995)
Kawashima,H., Sequeira, D.J., Nelson, D.R. and Strobel,H.W.
Protein expression and catalytic activity toward imipramine N-
demethylation of
a novel rat brain cytochrome P450 CYP2D18.
Biochem Biophys Res. Commun. submitted
note: this gene was cloned and sequenced from two independent
libraries.
This appears [not] to be a distinct gene from CYP2D4.
note: 2D18 is an alternate splice of an untranslated exon of
the 2D4 gene. The 5 aa diffs are allelic variation
both haplotypes are found in the same library
This gene can be distinguished from CYP2D4 as alternative splice
variant CYP2D4_v2
CYP2D18X rat
GenEMBL U48219 S77859
ONLY 5 AA DIFFS to 2D4
Chr7: 120781146-120776576 (- strand)
note: 2D18 is an alternate splice of an untranslated exon of
the 2D4 gene. The 5 aa diffs are allelic variation
both haplotypes are found in the same library
This gene can be distinguished from CYP2D4 as alternative splice
variant CYP2D4_v2
CYP2D19 Callithrix jacchus (white-tufted-ear marmoset)
GenEMBL D29822
Igarashi,T., Sakuma,T., Isogai,M., Nagata,R. and Kamataki,T.
Marmoset liver cytochrome P450s: study for expression and molecular
cloning of their cDNAs
Arch. Biochem. Biophys. 339 (1), 85-91 (1997)
91% to 2D17, 90% to 2D42
CYP2D20 hamster
T. Sakuma
95% identical to CYP2D27
CYP2D20 Syrian hamster
no accession number
Kouichi Kurose
submitted to nomenclature committee 7/13/99
clone name SH2D3
1 amino acid diff with Sakumas sequence
CYP2D21 Sus scrofa (miniature pig)
GenEMBL D89502
Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
Drug Metab. Disp. 32, 376-378 (2004)
8 amino acid differences to CYP2D25
Cyp2d22 mouse
no accession number
J. Leonard and N. Blume
submitted to nomenclature committee
88% identical to rat 2D4
Cyp2d22 mouse
GenEMBL AF221525 NM_019823 frameshift x2 in exon 6, NT_039621.1
NT_039621.1 - strand
43812601 MRLPTGAELWPIAIFTVIFLILVNLMHWRQRWTAHYPPGPMPWPVLGNLLHMDFQNMPAGFQK 12413
43811089 LRGRYGDLFSLQLASESVVVLNGLTALREALVKHSEDTADRPPLHFNDLLGFGPRSQ 10919
43810677 GIVLARYGPAWRQQRRFSVSTMHHFGLGKKSLEQWVTEEARCLCAAFADHTG 10522
43810448 PFSPNTLLDKAVCNVIASLLYACRFEYDDPRFIRLLGLLKETLKE 10314
43809907 FLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTWDPTQPPRDLTDAFLAEVEK 9731
43809546 AKGNPESSFNDE 9511
43809509 NLRTVVGDLFSAGM 9468
43809466 VTTSTTLSWALMLMILHPDVQ 9404
43809193 RVQQEIDEVIGQVQCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPK 9008
43808581 GTTLITNLSSALKDETVWEKPLCFHPEHFLDAQGHFVKPEAFMPFSA 8441
43808344 GRRSCLGEPLARMELFLFFTCLLQRFSISVPDGQPQPSDHGVFRALTTPCPYQLCALPR 8168
CYP2D23 rabbit
no accession number
Yukio Yamamoto
submitted to nomenclature committee
Clone name rabbit 2D/Clone I
CYP2D24 rabbit
no accession number
Yukio Yamamoto
submitted to nomenclature committee
Clone name rabbit 2D/Clone II
CYP2D25 Sus scrofa (pig)
GenEMBL Y16417, NM_214394
Postlind, H., Axen, E., Bergman, T. and Wikvall, K. (1997)
Cloning, structure and expression of a cDNA encoding vitamin D3 25-hydroxylase.
Biochem. Biophys. Res. Commun. 241, 491-497.
note: this is a microsomal emzyme different from the mitochondrial CYP27
which also has vitamin D3 25-hydroxylase activity.
Cyp2d26 mouse
GenEMBL NT_039621.1 - strand
68 ESTs see UNIGENE Mm.29064
MGLLVGDDLWAVVIFTAIFLLLVDLVHRRQRWTACYPPGPVPFPGLGNLLQVDFENIPYS
FYKLQNRYGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIYNHIGYGHKSK
GVILAPYGPEWREQRRFSVSTLRDFGLGKKSLEQWVTEEAGHLCDAFTKEAEHPFNPSPL
LSKAVSNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEVLNAIPMLLHIPGLP
DKAFPKLNSFIALVNKMLIEHDLTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDKNLRI
VVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDEVIGHVRHPEMADQARMPYTN
AVIHEVQRFADIVPTNLPHMTSRDIKFQDFFIPKGTTLIPNLSSVLKDETVWEKPLRFYP
EHFLDAQGHFVKHEAFMPFSAGRRSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSD
YGIYTMPVTPEPYQLCAVAR
Note: Brian Libby (bjl@jax.org) at The Jackson Laboratory has given his
permission to post sequence data he has on the 2d26 gene and a partial Cyp2d13
gene from mouse. He will make the BAC clone available to anyone who wants it.
The BAC has at least two and maybe more P450 sequences. I am putting a link to
a pdf version of the 2D26 gene sequence file here. It is color coded with
additional information, such as sequencing primers and restriction sites.
CYP2D26 gene sequence
Cyp2d26-de1b7b8b mouse
GenEMBL NT_039621.1 - strand
10kb upstream of 2d26, exon 1 aa 1-19, 36-57, exon 7,8
on the edge of the mouse 2d cluster
s in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
NT_039621.1 - strand
44262890 MGLQTGLWPMVISTALFCM 44262834
44262801 YPPSPVPLPELGSLLQVKFENM 44262736
44260947 GHVQKETDGIMGQVWLPQMSHQACMSFT 44260864
44260862 NAMIREV*HFRDTILVNLSHVTFCEIEI*GFXXXX 44260770
44260251 XXXXLITNLSLVLKNEITWEMPSPTPS*TFLESEGHLMKQETFMPXXX 44260129
CYP2D27 syrian hamster
no accession number
Kouichi Kurose
95% identical to CYP2D20
submitted to nomenclature committee 6/29/99
CYP2D28 syrian hamster
no accession number
Kouichi Kurose
71% identical to CYP2D27 73% to CYP2D20
clone name SH2D2
submitted to nomenclature committee 7/13/99
CYP2D29 Macaca fuscata (Japanese monkey)
GenEMBL AF301911 (release date March 1, 2001)
Shizuo Narimatsu, Hiroyuki Hichiya, Shigeo Yamamoto, Kazuo Asaoka
Submitted to nomenclature committee Oct. 16, 2000
95% to CYP2D6
CYP2D30 Callithrix jacchus (white-tufted-ear marmoset)
GenEMBL AY082602
Hichiya,H., Yamamoto,S., Asaoka,K. and Narimatsu,S.
Complementary DNA cloning and characterization of a cytochrome P450
2D enzyme from Marmoset monkey liver
Unpublished
submitted to nomenclature committee 3/5/02
33 diffrerences to 2D19 also from marmoset.
93% to 2D19, 91% to 2D29, 90% to 2D17
CYP2D31P human
NT_022676.10|Hs3_22832 chromosome 3
2D6 pseudogene fragment I-helix
899650 NQENLV*VVIDLFLGGTDTTATTLCWALIHMIQHGAVQ 899537
Cyp2d32-ps mouse
GenEMBL XM_194978, NT_039621.1
exons 4,5,6,7,8,9 NT_039621.1 + strand (vvp = old temp. name)
43898939 AMSPHNPNHLLDKAICNVIASLIYACRFKYGDPDIIK 33899049
ILKVLKESM*KKIVFIPD
43899746 VLNIFPIVLSISGLGDKVLPGKKVSLAIVDKMLTDXXX 33899850
43899865 TWDPD*SHCDLTDAFLAEMEQ 33899927
43900101 LHLLILHLLGAGIVMSSVTLTWTLLLMI*NPDVQ 33900202
43900439 XXXXEIDKVIGQVWHPEMADQVLMPFTNAVIHEVKCSEDITAMALPHRNSLHSNVQGFLIPK 33900612
43901007 GKSLITNLSSELKDEAIWEKPLCFHPEYFLDAKGHFV*HEPFMAFSE 33901147
43901248 GHQACLREPLACMELFLFFTFLLQRFSFSMSDGQPLPSEYSIYAMPVTPEPCQFCAVVQYQG 33901433
Cyp2d33-ps mouse
GenEMBL NT_039621.1
exons 4,5,6,7,8,9 NT_039621.1 + strand 3kb downstream of 2d12
44019279 XXXNPYHLLDKAVCNVIPSLIYACCFNYGDPDNRMLKLLKKKSMKKKIGFISD 44019428
44020071 VLNTFPTLLGISGLAEKVFSGQKTSFTIVNKMFTEH 44020178
44020190 DPDQPPRDLTDAFLAEMEK 44020246
44020381 AKGNSERSFREPNLYLIILDLLGPGIVTSLVTLTWSLLLVIQQPDVQ 44020521
44020745 XXXXEIDKVIG*VWHPEMAD*ILMPFTNVVIHEVKRFEDITAMVLPQRTSPDIDVHGF 44020906
44022181 XXXLIPDLSSMLKDETVWEKPLHFHPKNFLDAQGHFL*FEAFMPFSEG 44022315
44022418 QACLGQPLDQIVLFLFITCLLQCFSFSLPKGQPPPSD*GIYAMPVTPAPSQLCAVVVR*EEQWH 44022609
Cyp2d34 mouse
GenEMBL NT_039621.1
85% to 2d10 87% to 2dww/2d11 NT_039621.1 - strand
old temp. name = tt
44079756 MELLTGTGLWSVAIFTVIFLILVDLMHRRQHWTSRYPPGPVPWPVLGNLLQVDLDNIPYSLYK 44079568
44077878 LQNRYGDVFSLQMAWKPVVVINGLKAMQEVLLTCGKDTADHPPVPIFEYLGFKSKSQ 44077708
44077439 GVVLASYGPEWREQRQFSVSTLRNFGLGKKSLEEWVTKEAKHLCDAFTARAG 44077284
44077192 QSINPNTMLNNAVCNVIASLIFARRFEYEDPFLIRMLKMREESLKEVTGFIPG 44077037
44076407 VLNTFPILLRIPGLADMVFQSQKTFMAILDNLVTENRTTWDPDQPPRNLADAFLAEIQK 44076231
44076048 AKGNPESSFNDENLCMVVSDLFTAGMVTTSTTLSCALLLMILHPDVQ 44075908
44075711 RRVQQEIDAVIGQVRCPEMADQARMPYTNAVIHEVQRFGDIIPLNIPRITSRDIEVQDFLIPK 44075523
44075229 GTILIPNMSSMLKDETVWEKPLRFYPEHFLDAQGHFVKPEAFMPFSAG 44075086
44074985 RRSCLGEPLARMELFLFFTCLLQRFSFSVPAGQPQPSDHRIFAIPVAPYPYQVCAIMREQGH* 44074797
Cyp2d34-de1b2b7b8b mouse
GenEMBl NT_039621.1
detritus exons 1,2,7,8 about 4 kb downstream of 2d34
u in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
NT_039621.1 - strand
44070344 MELLTGTGL 44070318
44070324 WPVAIFTVIFILLVDLMHRHQHWTSRCPPGPVPWPVLGDLLQVNVYNIPYSLYK 44070163
44069514 LKKSCGDMFSLHMGWKPMVMIKGLKSVQDVLVTCGEDTADCPKIPVFHYI 44069365
44067376 QVQKEIDKVIGQVWHPEMADLGLMPFKKSVIHEVHHFADITAIP 44067245
44066770 QGKSFIPNLCSMLKDETVWEKPLHFHPKHFLDAQGHFVKHEVFMPFSAG 44066624
Cyp2d35-ps mouse
GenEMBL NT_039621.1
This seq was assembled from several smaller pieces found earlier
NT_039621.1 - strand
44113633 VIWLLTGTGL 44113604
44113610 WPVAIFTVIFILLVDLIHLCQHWTSCYPPGPVPCPVLGNLLQVDLYNMPYSLYK 44113449
44112585 MFSLQMVWKPMVLIKELKSVQDVLVTCGGGTVDRPEIPIFHHIGCGPKAK 44112436
44112148 XXLLASYGPEW*EQRPFSVSILCNFSQGKKFLEQSVTDEAGHICDTFTAQAG 44111999
44111917 SPLKPYTLLDKTLCNVIVSLIYAHRFKYGGPDIIKMLKVLKDNMGGKIGLIPE 44111759
44111115 VLNTFPVLLHIPGLADKVFPGKKTFLTIMDKLVTEHKKIWDLYQPSCDLTGAFLAEMEK 44110939
44110801 AKGNPESSFRESNLCLVVLDLLGDGIVTSSVTLTWGLLLTILHLDVQ 44110661
44110375 MPYTNAVIHEVPCYDDIIPIFLPHRTSSDVEMQDFLITK 44110259
44109226 SVLNDETVWEKSLCFLPDHFLDAQGNFVKPEAFMPFSAG 44109110
44109006 XQACLREPLAHMELFLFFTCLLQHFSFSVPAGQPLLSDYGIYTMPVSPEPYQLCAVVC* 44108833
Cyp2d36-ps mouse
GenEMBL NT_039621.1
NT_039621.1 - strand
44142171 MELLTETDLWPVAIFTVIFILLVELMHQCQR*TSFYTPGPVPWPLLGNLLQVDLDNMPYSLYK 44141983
44141174 NHYGDMSSLHMG*KSMVVISGLKAVQDVLVTC 44141079
44139955 GEDTTDCPEIPIFQHIGCGPKAK 44139887
44139615 GVVPAPYGLEWQEQR*FSVSTLCNFGL 44139535
44139535 GKKSLKQWVMEEAGH 44139491
44139399 SPLNPFPLLDKAGLNVSASLIYAHCFE*EDPVIIKMLTVLRK 44139274
44139026 VLNTFSIPLHIRGLADKAFPVQKTFLTIVDKMLTEHKRT*DPDKPP*DLIDAYLAKMKK 44138850
44138722 XXGNPESSFNETNLXX 44138687
44138681 VVLDQLGARIMTISITLT*VLLLMILHPHVQ 44138589
44138362 VGQYINKVISQVWHSGMADQGLMPFINVVIHEVQHFADIIAIPLPHRTSPDIKVLGSLIPK 44138180
44130610 GMNLIPNLSSVFKDNTVWEKPFCFHPEQFLDAQGHFVKHKAFMPFSAG 44130467
44130363 XQACLGDPLACMELFLFFTCILQRFSFSVPAGQPLHSDYGIYAMPVTPEPCQFCLV 44130199
Cyp2d37-ps mouse
GenEMBL NT_039621.1
Old temp name = hhp, 3 frameshifts and a stop codon 81% to 2d13
NT_039621.1 - strand
44151915 MELLTGTGLWPVVIVTVIFILLVDMLHRCQRWTSCCPPDPVPWPVLGNLLQVDLDNMPYNLYK 44151727
44150957 LHNRYGDVFSLQMGWNHMAVINGLKVIQEVLVTCGEDTADRPEMPIFPHLGYGQKAK 44150787
44150509 GVVLAPYGPEWKEQR*FSASTLCNFSLGKKSLEQWVMEEVGHLFDVFTAHA 44150357
44150275 GSPLNPYPLLDKAVCNVIVSLIYAHRFEYGDPDFIKMLKVLKENMGENIGLFSE 44150114
44149452 VLNTFPILLRIPGLADKVFPGQKTFLIMVDKLVTEHKRTWNSDQPPRDLTDAFMAEMEK 44149276
44149137 AKGNPESSFNDANLCLVVLDLLGAATVTTSTTLSWALLLMILHPDVQ 44148997
44148774 QVQQEIDEVIWYVWLPEMADQVCMPFTNAVIHEVQ 44148670
44148653 XXXDIIPITLPHRTSRDIEVWGFLIPK 44148582
44148149 GMTLISNLF 44148123
44148124 SVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSA 44148011
44147914 GHRSCLGEPLALMELFLFFTCLLQRFSFSMPAGQSLPSDYGIYTMPVTPAPYQLCAVV 44147741
Cyp2d38-ps mouse
GenEMBL XP_194978, LOC271298 chr 15 XM_194978, NT_039621.1 - strand
44166184 PVAIFTVILILLVNLMHRLQCWTSRYPPGPVPWLVLGNLLQADLHNMTYNLYK 44166026
44165213 LQNWCGDVFSLQMISKPVVVIKGLNAVGE 44165127
44165125 LLVSCGEGTAEWPEIPIFHHIVCGPKTK 44165042
44164762 GVILAP*GCEWREQR 44164718
44164722 RGSVSILCNFSLGKKSLEQCVMEKAGHICDAFTVQAG 44164612
44164557 SSLNPLSLLDKSLCNVVAYLIYA 44164489
Cyp2d39-ps mouse
GenEMBL NT_039621.1
Old temp name jj
Cyp2d26 like pseudogene exons 4,5,6,7,8(partial),9
NT_039621.1 - strand
44178330 FDYGDPDIIKMLKALKENKGEKIGMIPH 44178247
44177610 VLNTFPILLHILELADKVFPGQKT 44177539
44177539 ILTMVDKLVIAHKRTGDCEKPHQELTD 44177459
44177454 AFLAEREX 44177434
44177299 AKGNPESSFNDANLCLVVLDLFGGGILTSSITLTWAL*LVILHP 44177168
44176934 RVQQDEVIVHVW*PKMANQANMSYSNAAIHEIQCYADIIPIHLPDRTSLDI*VQGFLLPK 44176755
44176344 GTKIIPNLSSVI 44176309
44175091 GHQVCLGEPLASMELFLFFTCLLQCFSFLVPTG*PQPSNYGIYAMPVTPEPYQLCAVV 44174918
44175055 MELFLFFTCLLQCFSFLV 44175002 note 9kb from rest of N-term at 2d32p
Cyp2d40 mouse
GenEMBL NT_039621.1
Old temp name = rr 84% to 2d13
NT_039621.1 - strand
44223024 MELLTGTDLWPVAIFTVIFILLVDLLHRRQRWTSRYPPGPVPWPVLGNLLQVDLDNMPYSFYK 44222836
44222037 LQNHYGDMFSLQMGWNAMVIVNGLKAVQEALVTCGEYTADRPEMPIFPHLGYGQKDK 44221867
44221588 GLVLAPYGPEWQEQRRFSMSTMRNFGLGKKSLEQWVTEEAGHLCDAFTDQA 44221436
44221354 GSPLNPYTLLNKAVCNVIASLIYAHRFKYKDPDFIKMLKVLKENTREKIGLIPE 44221193
44220527 VVKMFPIVLRIPGLADKIFPGQKTFLTMVDKLVTEHKRTWDPDQPPRDLTDAFMAEMET 44220351
44220212 AKGNPESSFNEANLRLVVLDLFGGGIVTTSATLTWALLLMILHPDVQ 44220072
44219854 RRVQEEIDEVIGQARRPEMADQARMPYTNAVIHEVQRFADIAPMTLPHRTSCDIEVQGFLIPK 44219666
44219246 GTTLICNLSSVLKDETVWEKPLRFYPEHFLDAQGHFVKPEAFMPFSA 44219100
44218999 GRRACLGEPLVRMELFLFFTCLLQRFSFSVPDGQPLPSDYGIYSMVVSPAPYQLCAVVR* 44218820
Cyp2d40-de7b9b mouse
GenEMBL NT_039621.1
detritus exons 7,9 fragment NT_039621.1 - strand
t in Figure 5B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
44201031 VQQEINKFIGQVWRPETAVIHEVQCFANITPITLPHRTSCDIEVQGFLTPK 44200879
44200789 PSDYGIYSMPVTLEPYQLCVVVQ 44200721
Cyp2d41-ps mouse
GenEMBL NT_039621.1
old temp name = ssp, 82% to 2d13 one stop codon possible pseudogene NT_039621.1 - strand
44241024 MELLTGTDLWPVAIFTVIFILLVDLMHRHQRWTSRYPPGPVLWPVLGNLLQVDLDNMPYSLYK 44240836
44240062 LQNRYGDVFSLKLGRNPMVIVNRLMAVQEVLVTCGENTADRPEMPIFLPPSNGQKAK 44239892
44239602 GLAFAPYGPEWQEQKRFSMSTLRNFGLGKKLLEQ*MTKEAGHLCDAFTAQA 44239450
44239368 GSPLNPYTLLEKAMCNVIASLVYAHCFEYEDPDCIKMLRALKEYMIEKIGLIPEV 44239204
44238543 VKMFPIVLRIPGLADKIFPGQTTFLTMVDKLLTEHKRTWDPDQPPRDLIDAFLAEMEK 44238370
44238242 AKGNPESSFNEANLRQIVLDLFGAGTAPTSTTLSWALLLMILHPDVQ 44238102
44237884 SLVQEEIDEVIGQARRPEMADQARMPYTNAVIHEVQRFADIAPMTLPHRTSCDIEVQGFLIPK 44237696
44237268 QGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSA 44237125
44237024 GRRSCLGESLARMELFLFFTCLLQRFSFSVPDGQPQPSDYGIYSILVSPAPYQLCAVVR 44236848
CYP2D42 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
93% to CYP2D6, probable ortholog of CYP2D6
CYP2D43 Bos taurus (cow)
See cattle page for details
94% to 2D14 cow
5681 MGLLSGDTLGPLAVALLIFLLLLDLMHRRSRWAPRYPPGPMPLPVLGNLLQVDFEDPRPSFNQ
LRRRFGNVFSLQQVWTPVVVLNGLAAVREALVYRSQDTADRPPQALYKHLGFGPRAEG 6760
7291 VILARYGNAWREQRRFSLSTLRNFGLGKKSLEQWVTEEASCLCAAFADQA 7449
7550 GHPFSPMDLLNKAVSNVIASLTFGCRFEYNDPRIVKLLDVMEDGLKEEMKIMRQV 7714
8109 VEAVPVLLSIPGLAAKVVPGQKAFMTLVDELIAEQKMTRDPTQPPRHLTDAFLDEVKE 8288
AKGNPESSFSDENLRLVVADLFSAGMVTTSTTLAWALLLMILHPDVQR 8591
8806 RVQQEIDEVIGQVRRPEMGDQALMPFTVAVVHEVQRFADIVPLGLPHMTSRDIEVQGFHIPK 8985
9424 GTTLITNLSSVLKDETVWEKPFRFHPEHFLDAQGRFVKQEAFIPFSA 9603
GRRACLGEPLARMELFLFFTSLLQHFSFSVPAGQPRPSDHGVFVALVTPAPYQLCAVPR 9843
CYP2D44 Macaca fasicularis (cynomolgus monkey)
No accession number
ESTs BB890306, BB877128, BB888901, BB887284, BB877988, BB881640
Yasuhiro Uno
Submitted to nomenclature committee 9/29/2005
93% to M. mulatta 2D42, 92% to 2D17 M. fasicularis 91% to 2D6
differs from 2D17 another cynomolgus seq.
complete sequence
CYP2D45v1 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2D45v2 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2D46 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2D47 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2D48 Xenopus laevis
GenEMBL BC077934
56% TO CHICKEN 2D49
MSLLSQLCSFAFGCNVFTLGIICTLCLLLLDYMKRKKPCKNFPP
SPPSKPFVGNLLQLNFRNLNNSFKQLSKQYGDVMSLQVFWKPVVVLNGLEVMKEALIQ
KSEDTADRPEFHVLEILGFVGNNKAVVLANYGQSWKDLRRFTLSTLRDFGMGKKSLEE
RVREEAGYLCAAFQSEQGRPFDPHILLNTAVSNVICSIIFGERFEYDDHTFQKLLCLI
EESVKAESGAVPQIIASLPWSSKIPGLAKMFFQPRIRMLKYLQEIIKDHQQTWDSGHT
RDFIDAFMLEMEKAKGVKDSNFNEQNLLLTTADLFSAGSETTNTTLRWGLLFMLLYPN
VQRKVHEEIDHVIGRTRKPTMGDVLQMPYTNAVIHEIQRYVDIVPLSVPHMTYRDTHI
QGFFIPKGVTIMTNLSSVLKDEKAWEKPFQFYPEHFLDRDGKFVKREAFMAFSAGRRV
CLGEQLARMELFLFFTTLLQRFSFQIPNGEPSPREDPVFVFLQLPHDYKMCAKVR
CYP2D49 Gallus gallus (chicken)
chr1:46131304-46140141
ENSGALT00000019412.2
MTLLLWLSSWSNISVLGVFLTVFTILVDFMKRRKKWSRYPPGPMPLPFVG
TMPYVNYYNPHLSFEKFRKKFGNIFSLQNCWTNVVVLNGYKTVKEALVNK
SEDFADRPYMPVYEHLGYGHKSEGLVLARYGHLWKELRKFTLTTLRNFGM
GKKSLEERVTEEAGFLCSAISSEGGHPFDPRFLVNNAVCNVICTITYGER
FDYGDKTFKKLLTLFENSLNEEAGFLPQLLNVAPVLLRIPGLPQKIFPCQ
KAYVDFTQMLIDKHKETWNPAYIRDFTDAFLKEMAKGKEAEENGFNKSNL
TLVTADLLVAGSETTATTLRWAFLFMLLYPEIQSKVHKEIDKVIGRNRPP
TMADQVNMPYTNAVIHEVQRFGDVVPMGLPHMTYRDTELQGFFIPKGTTI
ITNLTSVLKDETAWKKPNEFYPEHFLNENGQFVRPEAFLPFSAGRRACLG
EQLTRMELFIFFTTLMQKFTFVFPEDQPRPREDSHFAFTNSPHPYQLRAV
PSITQDQGK
CYP2D50 horse
No accession number
Heather Knych
Submitted to nomenclature committee Oct. 3, 2007
80% to cattle CYP2D14 and CYP2D43
Cyp2d-se1[1:8:9] mouse
GenEMBL NT_039621.1
old temp name = xxp
about 400,000 bp from the main Cyp2d cluster
+ strand solo exons 1,8(partial),9 frameshift in exon 1
ortholog to CYP2D-se2[9] rat
43401344 MGLLTS 1361
43401361 LLSVAIFAAIFLLLVDIMQRCQCWATCYLLLLDFQNMPYSLYK 1489
43402076 EETVWEKPLRFHPELFLDAQGHFVKPEAFMPFSA 2177
43402729 GHRSCLGEPLACMKLFLFFTCLLQRFSFSVPDGQPQPSNCGVFPFLVAPSLYQLCAVLLKQGH 2917
CYP2D-se2[9] rat
UCSC browser chr7:120386407-120386565
exon 9 (+ strand) 73% to 2D3
ortholog to Cyp2d-se1[1:8:9] mouse
ACLGEPLTCMELFLFFICLLQSFSFSVKAGQPRPSNHGIFEMPISPSSYQLCA
2E Subfamily
CYP2E1 human
PIR A60554 (18 amino acids)
Robinson, R.C., Shorr, R.G.L., Varrichio, A., Park, S.S.,
Gelboin, H.V., Miller, H. and Friedman, F.K.
Human liver cytochrome P-450 related to a rat
acetone-inducible, nitrosamine-metabolizing cytochrome
P-450: identification and isolation.
Pharmacology 39, 137-144 (1989)
CYP2E1 Macaca fasicularis (cynomolgus monkey)
No accession
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
Only 3 aa diffs to CYP2E1 Macaca mulatta (rhesus monkey)
Note: the 2E1 seq from 1992 S55205 differs from this
seq at 12 amino acids and a frameshifted region, but this
seq matches rhesus monkey at 9/11 sites so this seq is probably more
accurate. One site is not included in the shorter S55205 seq.
CYP2E1 Macaca fasicularis (monkey)
GenEMBL S55205 (1508bp) Swiss P33266 (449 amino acids)
PIR S28167 (449 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP2E1 Macaca mulatta (rhesus monkey)
NM_001040213
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
94% to CYP2E1, ortholog of CYP2E1
CYP2E1 Mesocricetus auratus (hamster)
GenEMBL D17449 (2512bp)
Sakuma,T., Takai,M., Yokoi,T. and Kamataki,T.
Molecular cloning and sequence analysis of hamster CYP2E1
Biochim. Biophys. Acta 1217, 229-231 (1993)
CYP2E1 hamster
PIR S27176 (34 amino acids)
Puccini, P., Menicagli, S., Longo, V., Santucci, A. and Gervasi,P.G.
Purification and characterization of an acetone-inducible
cytochrome P-450 from hamster liver microsomes.
Biochem. J. 287, 863-870 (1992)
CYP2E1 rat
GenEMBL S48325 (1093bp)
Richardson,T.H., Schenkman,J.B., Turcan,R., Goldfarb,P.S.
and Gibson,G.G.
Molecular cloning of a cDNA for rat diabetes-inducible
cytochrome P450RLM6:hormonal regulation and similarity to
the cytochrome P4502E1 gene.
Xenobiotica 22, 621-631 (1992)
CYP2E1 rat
PIR B27425 (34 amino acids)
Favreau, L.V., Malchoff, D.M., Mole, J.E. and Schenkman, J.B.
Responses to insulin by two forms of rat hepatic microsomal
cytochrome P-450 that undergo major (RLM6) and minor
(RLM5b) elevations in diabetes.
J. Biol. Chem. 262, 14319-14326 (1987)
CYP2E1 rat
GenEMBL AF061442
Yoo,M. and Shin,S.W.
The complete coding sequence of the rat brain cytochrome P450 2E1
Unpublished
Cyp2e1 mouse
GenEMBL L11650 (1827bp) Swiss Q05421 (493 amino acids)
Davis,J.F. and Felder,M.R.
Mouse ethanol-inducible cytochrome P450 (P450IIE1).
Characterization of cDNA clones and testosterone
induction in kidney tissue.
J. Biol. Chem. 268, 24933-24939 (1993)
Cyp2e1 mouse
PIR A21231 (39 amino acids)
Ryskov, A.P., Ivanov, P.L., Kramerov, D.A. and Georgiev, G.P.
Mouse ubiquitous B2 repeat in polysomal and cytoplasmic poly
(A)+RNAs: uniderectional orientation and 3'-end localization.
Nucleic Acids Res. 11, 6541-6558 (1983)
C-terminal 39 amino acids
CYP2E1v1 dog
no accession number
Susan M. Lankford and Stephen A. Bai
submitted to nomenclature committee
CYP2E1v2 dog
no accession number
Susan M. Lankford and Stephen A. Bai
submitted to nomenclature committee
note: only one amino acid difference with 2E1v1
CYP2E1 Canis familiaris (dog)
NW_876287.1: 395882-405665
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
77% to human CYP2E1
MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAKLAEQYGPVFTLYLGSQ
RTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDRGITFNNGPGWKDTRRLSLSTLRDYGMGKRGNEERIQRE
IPFLLEALRGTRGQPFDPTFLLGFAPFNVIADILFHKHFDYSDQTGLRIQKLFNENFHLLSTGWLQLYNIFPSYL
HYLPGSHRKVLRNVAELKDYSLERVKEHQESLDPTCSRDFTDCLLQELQKERYGTEPWYTLDNIAVTVADLFFAG
TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRVPAIKDRLEMPYMDAVVHEIQRFIDLLPSNLPHVANQD
TMFRGYVIPKGTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGKSLARMELFLF
LSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHYKLCVVPRSG*
CYP2E2 rabbit
GenEMBL J03726 (multiple genomic fragments)
GenEMBL M19162 (multiple genomic fragments)
GenEMBL M19163 (multiple genomic fragments)
Khani,S.C., Porter,T.D., Fujita,V.S. and Coon,M.J.
Organization and differential expression of two highly similar
genes in the rabbit alchol-inducible cytochrome P-450 subfamily
J. Biol. Chem. 263, 7170-7175 (1988)
CYP2E1 sus scrofa (pig)
GenEMBL AB000885.1
Kimura,M., Kawakami,K., Suzuki,H. and Hamasima,N.
Cloning of the pig cytochrome P-450-j gene
Unpublished
CYP2E1 sus scrofa (pig)
GenEMBL AB052259
Misaki Kojima
2 amino acid differences with AB000885.1
Submitted to nomenclature committee Oct. 27, 2000
clone name c469
CYP2E1 Bos taurus (cow)
GenEMBL AJ001715
van Raak,M., Natsuhori,M., Ligtenberg,M., Kleij,L., ten Berghe,D.,
de Groene,E.M., Van Miert,A.S., Witkamp,R.F. and Horbach,G.J.
Isolation of a full length cytochrome P450 (CYP2E) cDNA sequence
and its functional expression in V79 cells
Unpublished
79% to human 2E1
MAALGITVALLVWMATLLFISIWKHIYSSWKLPPGPFPLPIIGNLLQLDIKNIPKSFTR
LAERYGPVFTLYLGSQRAVVVHGYKPVKEVLLDYKNEFSGRGENPGFQMHKNN
GIIFNNGSTWRDTRRFSLTTLRDLGMGKQGNEQRIQREAHFLLEVLRKTQ
GQPFDPTFVVGFAPYNVISDILFHKRFDYKDQTSLRLMSLFNENFYLLSSPWIQ
LYNNFPDYLQYLPGSHRKLLKNVSEVKSYALERVKDHQKSLEPSCPRGFLDTMLIEM
AKERHSVDPMYTLENIAVTVADLLFAGTETTSTTLRYGLLILMKYPEVE
EKLHEEIDRVIGPSRIPAVKDRLDMPYLDAVVHEIQRFIDLLPSNLLHEATQDTVFRGYVIPK
GTVVIPTLDSVLHDRQEFPEPEKFKPEHFLNENGKFKYSDHFKAFSA
GKRVCVGEGLARMELFLLLAAILQHFNLKSLVDPKDIDLSPIAIGFGKIPPRYKLCLIPRSKV*
CYP2E1 horse
No accession number
Heather Knych
Submitted to nomenclature committee Oct. 17, 2007
CYP2E1 Balaenoptera acutorostrata (Minke whale)
No accession number
Iwata Hisato
submitted to nomenclature committee 1/6/05
84% to CYP2E1 cow, 76% to CYP2E1 human
2F Subfamily
CYP2F1 human
GenEMBL J02906
MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLL
LLCSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYP
AFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLADVRKT
EGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYD
ILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASSPRDFIQCFLTKMAEEK
EDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGR
ARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLL
NTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGELLARMELFLYL
TAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRPR
CYP2F1 Bos taurus (cow)
See cattle page for details
LSKEFGAVYTVYLGPRRVVVLSGYQAVKEALVDQAEEFGGRGDYPVFFNFTKGN
GIAFSNGDRWKVLRKYSVQILRNFGMGKRTIEERILEEGHFLLEELRKTQ
GKPFDPTFVVSRSVSNIICSVIFGSRFDYDDDRPLSIIHLINENFQIMSSPWGE
MYNIFPNLLDWVPGPHRRLFKNYGRIKDIIARSVREHQASLDPNSPRDFIDCFLTRWH
QEKQDPLSHFFMDTLLMTTHNLLFGGTETVGTTLRHAFRLLMKYPEVQ
VRVQEEIDRVVGHERLPTVEDRAAMPYTDAVIHEVQRFADVIPMSLPHRVTRDTNFRGFTIPR
GTDVITLLNTVHYDPSQFLKPKEFNPEHFLDANMSFKKSPAFMPFSA
GRRLCLGEALARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPYQLCVLAR
CYP2F1P human
AC008537.3 93% identical to 2F1
Fernandez-Salguero,P., Hoffman,S.M., Cholerton,S., Mohrenweiser,H.,
Raunio,H., Rautio,A., Pelkonen,O., Huang,J.D., Evans,W.E.,
Idle,J.R. and Gonzalez, F.J.
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the
human CYP2A genes and identification of variant CYP2A6 alleles.
Am. J. Hum. Genet. 57, 651-660 (1995)
There are two 2F1 genes, and one pseudogene of 2F1 on chromosome 19.
GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGE
LYDIFPSLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLTKMAE
KKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQ
AHVQEEINLVVGHVRLPALKDRAAMPYTDMVIHEVQRFADIIPMNLPHRITRDTAFHGFLIPK
GTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG
HRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLHPR
CYP2F1 Canis familiaris (dog)
NW_876313.1:NW_876270.1:43272128-43283098
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
86% to human CYP2F1
MDGVSTAILLGLLALAFLFLILNSRGKSQLPPGPRPLPFLGNLLQLRSQDMLTSLTKSKEYGSVYTVHLGPRRVV
VLSGYQAVKEALVDQGEDFSGRGDYPVFFNFTKGNGIAFSNGDRWKVLRRFSVQILRNFGMGKRSIEERILEEGS
FLLAELRKTEGKPFDPTFVLSRSVSNIICSVIFGSRFDYDDERLLTIIRLINDNFQIMSGPWGEQLYNIFPSLLD
WIPGPHRRLFQNFGCMKDLIARSVRDHQDSLDPRCPRDFIDCFLNKMAQEKQDPHSHFHMDTLLMTTHNLIFGGT
ETVGTTLRHAFLVLMKYPKVQARVQEEIDRVVGRARLPALEDRAAMPYTDAVIHEVQRFADVIPMNLPHRVIRDT
PFRGFLLPKGTDIITLLNTVHYDPNQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYL
TAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLRLRTR*
Cyp2f2 mouse
GenEMBL M77497, NT_039413.1 + strand
Swiss P33267 (491 amino acids)
Ritter J.K., Owens I.S., Negishi M., Nagata K., Sheen Y.Y.,
Gillette J.R. and Sasame H.A.
Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA
cloning, sequence and expression in Saccharomyces cerevisiae.
Biochemistry 30, 11430-11437(1991)
CYP2F3 goat
GenEMBL AF016293
Huifen Wang, Diane L. Lanza, and Garold S. Yost.
Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates
The selective pneumotoxins 3-methylindole and naphthalene
submitted
CYP2F4 rat
GenEMBL AF017393
R. Michael Baldwin and Alan Buckpitt
submitted to nomenclature committee
CYP2F5 Gorilla gorilla
GenEMBL AF372494
Chen,N., Whitehead,S.E., Caillat,A.W., Gavit,K., Isphording,D.R.,
Kovacevic,D., McCreary,M.B. and Hoffman,S.M.
Identification and cross-species comparisons of CYP2F subfamily
genes in mammals
Mutat. Res. 499 (2), 155-161 (2002)
CYP2F6 Macaca mulatta (rhesus monkey)
No accession number
Mike Baldwin
Pdf file of nucleotide/amino acid alignment
This file shows polymorphism data
The particular sequence shown is a pseudogene due to
A premature stop codon.
PDF file for the sequences of a non-truncated version
Pdf files from Mike Baldwin
2G Subfamily
CYP2G1P human
GenEMBL S80997, S80998, S80999
Sheng J, Ding X
Biochem. Biophys. Res. Commun. 218, 570-574 (1996)
Identification of human genes related to olfactory-specific CYP2G1.
2 PCR fragments for a human 2G1 are presented and 2 more PCR
fragments from two possible 2G1 pseudogenes are also shown.
86% identical to rat 2G1
CYP2G1P human
GenEMBL AC008537 genomic DNA in 93 fragments
Sequence is assembled from fragments and it may need to be revised
The * indicate intron locations except the last one that is a stop
codon. The sequence is 78% identical to rat 2G1.
There is a frameshift after YMGP on the second line.
CYP2G1 is 58-59% identical to some CYP2A sequences so it may actually
Be a CYP2A sequence. The 2G subfamily might be absorbed by CYP2A
CYP2G1P revised seq AC008537 missing exons 4, 5 and 6
MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK
LREKYSPVFTVYMGP (fs) RPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG
VALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK
AKIHEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGRGK
RICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR
CYP2G1 chimp
Not a pseudogene
CYP2G1 Bos taurus (cow)
See cattle page for details
88% to human pseudogene 2G2P
3860 MELGGAFTIFLALCLSCLLILIAWKRMSKGGKLPPGPTPIPFLGNVLQVRTDATFQSFMK(0) 4039
4854 LKEKYGPVFTVYMGPRPVVVLCGHEAVKEALVDRADEFSGRGELASVERNFQGH(1)5015
6748 GVALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEAGFLLVELRKTR(1)6897
8738 GARIEPTFFLSRTVSNVISSVVFGSRFDYEDQQFLKLLQMINQSFIEMSTSWAQ (0) 8899
9151 LYDMYSGIMQYLPGRHNRIYYLIEELKDFIASKVKINEASLDPQNPRDFIDCFLIKMHQ(0) 9327
300 DKNNPHTEFNLKNLVLTTLNLFFAGTETVSSTLRYGLLLMMKHPEVE(1)145
997 AKIHEEIDQVIGPHRIPSVDDRAKMPYTDAVIHEIQRLTDIVPMGVPHNVIRDTHFRGYLLPK(0) 1185
1314 GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGHFKKNEAFVPFSS(1) 1454
586 GKRICLGEAMARMELFLYFTSILQNFSLRSLVPPADIDITPKVSGFGNIPPTYELCFMVR(1) 765
CYP2G1 rat
GenEMBL M33296
CYP2G1 rabbit
PIR B31944 (50 amino acids)
Ding, X. and Coon, M.J.
Purification and characterization of two unique forms of
cytochrome P-450 from rabbit nasal microsomes.
Biochemistry 27, 8330-8337 (1988)
Cyp2g1 mouse
GenEMBL L81171, NM_013809, NT_039410.1
Hua, Z., Zhang, Q.Y., Su, T., Lipinskas, T.W., Ding, X.
cDNA cloning, heterologous expression, and characterization of
mouse CYP2G1, an olfactory-specific steroid hydroxylase.
Arch. Biochem. Biophys. 340, 208-214 (1997)
94.9% identical to rat CYP2G1
CYP2G1 Canis familiaris (dog)
chr1:115782146-115791970 UCSC broswer May 2005 assembly
90% to human 2G2P
MELGGAFTIFLALSLSCLLILIAWKRNSKGGKLPPGPTPIPFLGNVLQVRTDATFQSFMK
LREKYGPIFTVYMGPRPVVVLCGHEAVKEALVDRADEFSGRGELASIERNFQGH
GVALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEAGFLLEELRKTK
GSPIEPTFFLSRTVSNVISSVVFGSRFDYEDKQFLKLLQMINESFIEMSTPWAQ
LYDMYSGIMQYLPGRHNRIYYLIEELKDFIASRVKINEASLDPQNPRDFIDCFLIKMHQ
DTNNPHTEFNLKNLVLTTLNLFFAGTETVSFTLRYGLLLMMKHPEVE
AKIHEEIDQVIGPHRIPSVDDRAKMPYTDAVIHEIQRLTDIVPMGVPHNVIRDTHFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSS
GKRICLGEAMARMELFLYFTSILQNFSLHSLVPPADIDITPRVSGFGNIPPTYELCLKAR
CYP2G2P human
AC008962 comp(28700-40696) seq of gene has two in frame stop codons
MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK
LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGHG
VALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK
GAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQ
LYDMYSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMH
QDKNNPRTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVE
AKIHEEINQVIGPHRLPRVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNLIRDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR
GKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKLSGFGNIPPTYELCLVAR*
CYP2G2 Macaca mulatta (rhesus monkey)
Note this does not look like a pseudogene
exon 2 = trace archive file 456149111
MELGGAVTIFLALCLSCLLVLIAWKRMNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK (0)
LKEKYGPLFTVYMGLWPVVVLCGHEAVKEALIDQADEFSGRGKLASIEQNFQGH (1)
GVALANGERWRILRRFSLTILRDFGMGKRSIEERILEEASYLLEEFRKTK (1)
GAPIDPTFLLSRTVSNVISSVVFGSRFDYEDKQFLNLLRLINESFIEMSTPWAQ (0)
LYDMYSGIMQYLPGRHNRVYYLIEQLKDFIASRVKINEASFDSQNPRDFIDCFLIKMHQ (0)
DKNNPRTEFNLKNLVLTALNLFFAGTETVSSTLRYGFLLLMKHPEVE (1)
ARIHEEINQVIGPHRLPSVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNVIRDTQFRGYLLPK (0)
GTDVFPLLGSVLKDPKYFRYPEAFYPQHFLDEQGRFKKNEAFVPFSS (1)
GKRICLGEAMARMELFLYFTSILQNFSPRSLVPPADIDITPKLSGFGNIPPTYELCLVAR
2H Subfamily
CYP2H1 chicken
PIR D44107 (22 amino acids)
Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
Beta-naphthoflavone induction of a cytochrome P-450
arachidonic acid epoxygenase in chick embryo liver distinct
from the aryl hydrocarbon hydroxylase and from
phenobarbital-induced arachidonate epoxygenase.
J. Biol. Chem. 267, 19503-19512 (1992)
CYP2H2 chicken
PIR E44107 (25 amino acids)
Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
Beta-naphthoflavone induction of a cytochrome P-450
arachidonic acid epoxygenase in chick embryo liver distinct
from the aryl hydrocarbon hydroxylase and from
phenobarbital-induced arachidonate epoxygenase.
J. Biol. Chem. 267, 19503-19512 (1992)
2J Subfamily
CYP2J1 rabbit
GenEMBL D90405
Kikuta, Y., Sogawa, K., Haniu, M., Kinosaki, M., Kusunose, E., Nojima, Y.,
Yamamoto, S., Ichihara, K., Kusunose, M. and Fujii-Kuriyama, Y.
A novel species of cytochrome P-450 (P-450ib) specific for the small intestine
of rabbits.
J. Biol. Chem. 266, 17821-17825 (1991)
CYP2J2 human
GenEMBL U37143 (1876bp)
Wu, S., Moomaw, C., Tomer, K.B., Capdevila, J.H., Falck, J.R.,
and Zeldin, D.C.
Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450
Arachidonic Acid Epoxygenase Highly Expressed in Heart.
J. Biol. Chem., 271: 3460-3468 (1996)
CYP2J2 Macaca fasicularis (cynomolgus monkey)
No accession number
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP2J2_2-B5
94% to 2J2 human
CYP2J2 Canis familiaris (dog)
NW_876313.1 :19927114-19956047
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
78% to human CYP2J2
MLAAVGSLAATLWAVLHLRTLLLGAVAFLFFADFLKRRRPKNYPPGPVPLPFVGNFFHLDFEQSHLKLQRFVKKY
GNVFSVQMGDMPLVVVTGLPLIKEVLVDQNQVFVNRPITPIRERVFKNSGLIMSSGQIWKEQRRFTLATLKNFGL
GRKSIEERIQEEAHHLIQAIEEENGQPFNPHFKINNAVSNIICSITFGKRFEYQDEQFQELLRLLDEVTCLETSM
RCQLYNVFPWIIKFLPGPHQKLFNDWEKLKLFIAHMTENHRRDWNPAEPRDFIDAYLKEMEKGNATSSFHEENLI
YSTLDLFFAGTETTSTTLRWGLLYLALNPEIQEKVQAEIDRVIGQSQLPGLAVRESMPYTNAFIHEVQRMGNIVP
LNVPREVTGDTTLAGYYLPKGTVIVTNLTALHRDPAEWATPDTFNPEHFLENGQFKKREAFLPFSIGKRVCIGEQ
LARSELFIFFTSLVQRFTFRPPDNEKLSLEFRTGLTISPVSHRLRAIPRS*
CYP2J3 rat
GenEMBL U39943 (1778bp)
Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J.,
Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C.
Molecular Cloning, Expression, and Functional Significance of a Cytochrome
P450 Highly Expressed in Rat Heart Myocytes. submitted.
91% to mouse 2j9 exon 8 in a seq gap
UCSC browser chr5 shown below
116772039 MLVTAGSLLGAIWTVLHLRILLLAAVTFLFLADFLKHRRPKNYPPGPWRLPLVGCLFHLDPKQPHLSLQQ 116771830
116767788 FVKKYGNVLSLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKN 116767791
116766010 GLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQEEAYHLVEAIKDEG 116765861
116765445 GLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAMCLESSMMCQ 116765284
116760602 LYNIFPRILQYLPGSHQTLFSNWRKLKLFISDIIKNHRRDWDPDEPRDFIDAFLKEMAK 116760426
116758387 YPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQ 116758247
116754923 EKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFNLPK 116754735
GTMILTNLTALHRDPKEWATPDTFNPEHFLENGQFKKRESFLPFSM
116749991 GKRACLGEQLARSELFIFITSLIQKFTFKPPVNEKLSLQFRMSVTISPVSHRLCAIPRL 116749815
CYP2J3P1 rat
GenEMBL U40000 (1909bp)
Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J.,
Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C.
Molecular Cloning, Expression, and Functional Significance of a Cytochrome
P450 Highly Expressed in Rat Heart Myocytes. submitted.
Not a true pseudogene, but an alternative splice variant of CYP2J3
MLVTAGSLLGAIWTVLHLRILLLAAVTFLFLADFLKHRRPKNYPPGPWRLPLVGCLFHLDPKQPHLSLQQ
FVKKYGNVLSLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKN
GLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQGEAYHLVEAIKDEG
GLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAMCLESSMMCQ
LYNIFPRILQYLPGSHQTLFSNWRKLKLFISDIIKNHRRDWDPDEGRDFIDAFLKEMAK
YPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQ
EKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPRKVAVDTYLAGFNLPK
GTMILTNLTALHRDPKEWATPDTFNPEHFLENGQFKKRESFLPFSM (GC boundary, retains intron)
GKRACLGEQLARSELFIFITSLIQKFTFKPPVNEKLSLQFRMSVTISPVSHRLCAIPRL
CYP2J3P2 rat
GenEMBL U40004
Wu, S., Murphy, E., Gabel, S., Chen, W., Tomer, K.B., Foley, J.,
Steenbergen, C., Falck, J.R., Moomow, C.R., and Zeldin, D.C.
Molecular Cloning, Expression, and Functional Significance of a Cytochrome
P450 Highly Expressed in Rat Heart Myocytes. submitted.
Not a true pseudogene, but an alternative splice variant of CYP2J3
MLVTAGSLLGAIWTVLHLRILLLAAVTFLFLADFLKHRRPKNYPPGPWRLPLVGCLFHLDPKQPHLSLQQ
FVKKYGNVLSLDFANIPSVVVTGMPLIKEIFTQMEHNFLNRPVTLLRKHLFNKN
GLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQEEAYHLVEAIKDEG
GLPFDPHFNINKAVSNIICSVTFGERFEYHDSQFQEMLRLLDEAMCLESSMMCQ
LYNIFPRILQYLPGSHQTLFSNWRKLKLFISDIIKNHRRDWDPDEPRDFIDAFLKEMAK
YPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEVQ
EKMQAEIDRVIGQGRQPNLADRDSMPYTNAVIHEVQRIGNIIPFNVPREVAVDTYLAGFNLPKG
(small deletion)
RDPKEWATPDTFNPEHFLENGQFKKRESFLPFSM
GKRACLGEQLARSELFIFITSLIQKFTFKPPVNEKVSLQFRMSVTISPVSHRLCAIPRL
CYP2J4 rat
GenEMBL L81170 (1826bp)
Zhang,Q.-Y., Ding,X., Kaminsky,L.S.
cDNA cloning, heterologous expression, and characterization of rat
intestinal CYP2J4
Arch. Biochem. Biophys. 340, 270-278 (1997)
UCSC browser chr5 shown below
116734902 MLATAGSLIATIWAALHLRTLLVAALTFLLLADYFKTRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQP 116734693
116725983 FVKKYGNIFSLNLGDITSVVITGLPLIKETFTHIEQNILNRPLSVMQERITNKN 116725822
116723426 GLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRMQEEAHYLVEAIREEK 116723277
116722875 GKPFNPHFSINNAVSNIICSVTFGERFEYHDSRFQEMLRLLDEVMYLETTMISQ 116722714
116718583 LYNIFPWIMKYIPGSHQTVFRNWEKLKLFVSSMIDDHRKDWNPEEPRDFIDAFLKEMSK 116718407
116716306 YPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQ 116716169
116713582 EKVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGFHLPK 116713394
116711364 GTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSM 116711227
116708412 GKRACLGEQLARSELFIFFTSLMQKFTFKPPTNEKLSLKFRNGLTLSPVTHRICAVPRE* 116708233
CYP2J4-de6b rat
UCSC browser chr5: 116706163-116706053 (- strand)
exon 6, frag w in fig. below
116706163 XXXXXXSFCEENLTCRTLDFLYAGIDTISNRLHWVLLLTCVNPEXX 116706053
rat, mouse and human 2J cluster
Cyp2j5 mouse
GenEMBL U62294 (1886bp), NT_039263.1
J. Ma and D.C. Zeldin, unpublished.
clone JM-6
CYP2J5P rat
UCSC browser Chr5: 116785102-116780337 (- strand)
exons 1-4 69% to 2j5 mouse
now a pseudogene ortholog
116785102 MITSLSSLVTSSWAALLLRTLLLAAVTFLFLAGILRRHRPKDYQPGPWRLPFVGNFFQIDFEQSHLVLQK 116784893
116784415 FAKKYGNVFSLELDRPSVVVVTGQPLIKTKMFTHLEQNFANHFVTSVRKRAIGNN 116784251
116781318 GLITSNGQTWKEKRRFALMTLKNFGLGKKSLEQRMHE*AFHLVEARREEG 116781169
116780474 GQPVDLHLINNAVANVICSITFGGRFEYEDCQFQEMPTLLDEALHV 116780337
Cyp2j5-de2b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 2
q in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7613530 FVKKYGNLFSLELDSISVEVVSGLL 7613456
7613456 LIKEMFTHLDHNFVNRPVSAIQKHV 7613382
Cyp2j5-de9b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 9
r in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7603742 GK*ACPGEHLAISELFIIFTDLM*NFTFKAPINQKLSLS 763626
7603626 FRNGLTLSPVSYHICAVPQQ* 7603564
Cyp2j6 mouse
GenEMBL U62295 (2046bp) NT_039263.1
J. Ma and D.C. Zeldin, unpublished.
clone JM-15
Cyp2j6-de6b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 6 fragment
s in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7513690 TGFNKENLTCDTLDLLSGGIDTTSNGVHWVLLYRSVNKE 7513574
Cyp2j7 mouse
GenEMBL XM_143894.1, NT_039263.1|Mm4_39303_30, AF218856
D.C. Zeldin, unpublished.
Cyp2j7-de9b mouse
GenEMBL NT_039263.1|Mm4_39303_30
from old Cyp2jzzp
w in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7177505 GKGACLGKQLAMSQLFIFFTSLMQKSTFKPPINENLSLKFTMSP 7177374
7177375 LSPVSHHIYAVPRQ 7177334
Cyp2j7-de9c mouse
GenEMBL NT_039263.1|Mm4_39303_30
from old Cyp2jzzp
x in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7157638 GNRACPGEQLAMIELFIFFTALMQKCTFKSTVNEKLGLKIRLDLPLSPVSHHICAVPRQ 7157462
Cyp2j7-de9d mouse
GenEMBL NT_039263.1|Mm4_39303_30
from old Cyp2jzzp
y in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7138888 GKRTCHGKQLARSELFIFFTALMHIFTLNPPISKKLSLKFSMGLAFSPVSH*ICVVPTQ 7138712
Cyp2j8 mouse
GenEMBL NT_039263.1|Mm4_39303_30
AF218857 AI429871 vv77f02.y1 69-184 (EST),
AA760476 vv77f02.r1 69-227 (EST), AZ393698 283-329 (GSS), AI606765
vv77f02.x1 330-476 (EST) AZ057726 422-463 (GSS), XM_131520.1 (from nr)
AL772157.1 htgs AC102925.1
D.C. Zeldin, unpublished.
clone WQ4-1
Cyp2j8-de2b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 2
t in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7429084 LEKYGNNFSLILGD*TLVVITELLLTKEACIHMEQNILNHPATFIQECNSKK 7428929
Cyp2j8-de9b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 9
u in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7417728 ERLIRSKIFSFTLSLKMKSSIYMEVFSFKP 7417639
Cyp2j8-de9c mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 9
v in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7414356 EQLARSEMFIFFIALMEKFTFKASVNEKLSLKFRMGFNLPQVSHNICAVPRY* 7414198
Cyp2j9 mouse
GenEMBL NT_039263.1|Mm4_39303_30 AK018422 lung, also AF336850
D.C. Zeldin, unpublished.
clone WQ24-1
CYP2J10 rat
GenEMBL XM_233199
Yu Z, Huse LM, Adler P, Graham L, Ma J, Zeldin DC, Kroetz DL.
Mol Pharmacol 2000 May;57(5):1011-20
Increased CYP2J expression and epoxyeicosatrienoic acid formation in
spontaneously hypertensive rat kidney.
ortholog of mouse Cyp2j12
Predicted by GNOMON 86% to 2j12 mouse (LOC313373), mRNA.
2J10 seq specific rev primer matches 116499966-116499989
forward primer 1 = 116515946 116515968
116516004 MLSTEDTLEAAIRALLHFRTLLLAAVTFLFLANYLKTRRPKNYPPGPWRLPFVGNLFQLDVKQPHVVIQK 116515795
116508667 FVKKYGNLTSLDFGTIPSVVITGLPLIKEAFTNTEQNFLNRPVTPLRKRVFNNN 116508506
116505791 GLIMSNGQTWKEQRRFTMTTLKNFGLGKRSLEQRIQEEANYLVEAIGADK 116505642
116505144 GQPFDPHFKINSAVSNIICSITFGERFEYEDSLFQELLRLLDEASCLESSMMCQ 116504983
116500081 LYNVFPTIIKYLPGSHQTVLRNWEKLKLFISCMMDSHQKDWNPDEPRDFIDAFLTEMAK 116499905
116496152 YRDKTTTSFNKENLIYSTLDLFFAGSETTSNILRWSLLYITTNPEVQ 116496012
116489147 EKVHSEIDRVIGHRRQPSTGDRDAMPYTNAVIHEVLRMGNIIPLNVPREMTADSTLAGFHLPK 116488959
116488244 GTTILTNLTGLHRDPKEWATPDTFNPEHFLENGQFKKRDSFLPFSM 116488107
116479687 GKRACPGEQLARTELFIFFTALMQNFTFKPPVNETLSLKFRNGLTLAPVSHRICAVPRQ 116479511
Cyp2j11 mouse
GenEMBL XM_131521, AC091461.3 Unigene Mm.26915, NT_039263.1
Joan Graves, Hong Wang, and Darryl Zeldin
Clone name CYP2JA
Cyp2j12 mouse
GenEMBL XM_143892 (genbank entry missing part of exon 4)
NT_039263.1|Mm4_39303_30
Cyp2j13 mouse
GenEMBL NT_039263.1|Mm4_39303_30
Map view locus LOC230459
Joan Graves, Hong Wang, and Darryl Zeldin
Clone name CYP2JC
CYP2J13 rat
GenEMBL XM_233198 1455 bp
ortholog of mouse Cyp2j13
Predicted GNOMON Rattus norvegicus similar to CYP2J4 (LOC313372) mRNA.
Missing exon 1 74% to XM_233199, 79% to 2J4
78% to 2J3 90% to 2j13 mouse
116449294 FVKKYGNVISLDLGIMSSVIISSLPLIKEAFSHLDENFINRPIFPLQKHIFNDN 116449133
116446157 GLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRIQEEAHHLVEAIGEEE 116446008
116445630 GQPFDPHFKINNAVSNIICSITFGERFEYHDSQFQELLKLLDKAMYLGTPMMIH 116445469
116440971 LYNMFPWIIKHLPGQHQTLLATWGKLKSYIADIIENHREDWNPAEPRDFIDAFLNEMAK 116440795
116428766 YPDKTTTSFNEENLICSTLDLFLAGTETTSTTLRWAVLYMALYPEVQ 116428626
116426881 EKVQAEIDQVIGQEKHPSLADRDSMPYTNAVVHEIQRMGNIVPLNVPREVAVDTTLAGFHLPK 116426693
116426568 GSVVMTNLTALHMDPKEWATPDVFNPEHFLENGQFKKRDSFLPFSM 116426431
116423270 GKRACLGEQLARSELFIFFTALMQKFTFKPPTNEKLSLKFRLGITISPVSHRICAVPRL 116423094
Cyp2j13de1X mouse
Detritus exon 1 7kb downstream of 2j13 (exon 8)
Note: this is an early and incorrect nomenclature for Cyp2j13-de8b
Cyp2j13-de8b mouse
GenEMBL NT_039263.1|Mm4_39303_30
detritus exon 8 ABOUT 7000BP DOWNSTREAM OF 2J13
z in Figure 5D Nelson et al. Pharmacogenetics 14, 1-18 (2004)
7025751 GSVVLTNLTALQVDPKD*ATPDVVIPEHFLKNGEF*KGESFLPFSIG 7025611
>Cyp2j14-ps mouse
GenEMBL NT_039263.1|Mm4_39303_30
exons 3,4,9
7377737 XXXXXSNGQTWKEQKRFALMILKNFELGKKSLEQHIQEEANHLLEAMGEEK 7377600
7376950 GQPFDPHY 7376927
7376925 VSNIICFITFGDHFEYDDNKFQELLKLTDETLCSEASMMLV 7376803
7353938 GKRSCPGEQMAISELFIFFT 7353879
7353880 LFTQKFTFSPPVNEKLKFKNGLTLSPVSHHICAVPRQ* 7353767
>Cyp2j15-ps mouse
GenEMBL NT_039263.1|Mm4_39303_30
exons 3,4,5,9
7271792 GFI*SSSQIWKD*RFILMTLKHFGLGKILVHLMQGESCCHLVGA 7271661
7271288 GQHSDLHFIINNAVCNIIFSVTFDCFLETHDCRFQEMLKLMDEFICLETTMLHQ 7271127
7245486 LYNVFPHLMKYILVSLQTVFRN 7245421
7245421 RGKLKLLASCMIDKHVRDWNPD*PRDFIDVFFKEMMK 7245311
7232303 GKRACHGEQLARSELFIF*TALIQKFVFKVPVNEKLSLKFRLGFPLPPVNHHIYAVPRD* 7232124
CYP2J16-de2b5b9b rat
UCSC browser (- strand) frag x in figure below
116691748 KKYGNIFGLNLGDLTSEVITGLLLSKE 116691668 exon 2
116684743 FYDIFPYLMKYIPGITSNCFQKLGKLKLFVSCMTDEHRRDWNPEDPRNFTDALLKEMMK 116684567 exon 5
116677505 GKRACPGEQLARSKLFIFFTALIQKFTF 116677422
116677420 RLGMKSILGLTLSPVTHHI*ALSKQ 116677346 exon 9
rat, mouse and human 2J cluster
CYP2J16 rat
UCSC browser (- strand)
116664772 MLATVGSLLAKIWSAINFWTLLLTLLTFLLLADYLKNRRPNNYPPGPWRLPFVGNLFQFDLNISHLHLRIQQ 116664557
116654396 FVKKYGNLISLDFGNISVVVITGLPLIKEALINNEQNFLKRPIVPSRYRVFKDN 116654235
116651622 GIFFANVHKWKEQRRFALTMLKNFGLGKKSLEQCIQEEAHHLVEVIGEEK 116651473
116650955 GQPFDPHFRINNAVSNIICSITFGERFEYDDSQFQELLKLADEVICSEASMTSV 116650794
116640170 LYNVFPLIFKYLPGPHQTVFKNWEKLKSIVANMIDRHRKDWNPDEPRDFVDAFLTEMTK 116639994
116638624 YPDKTTTSFNEENLIATTLDLFFAGTETTSTTLRWALLYITLNPEVQ 116638484
116627938 EKVHSEIDRVIGHGRLPSTDDQDAMPYTNAVIHEVLRMGNIIPLNVPREVTADSTLAGFHLPK 116627750
116624337 GKMILTNLTALHRDPKEWATPDTFNPEHFLENGQFKKRDSFLPFSV 116624200
116612610 GKRACPGEKLAKSELFIFFTALMQNFTFKAPTNEKLSLKLRKGLSLYPVSYRICAVPR 116612437
rat, mouse and human 2J cluster
CYP2J16-de5c6c9c rat
UCSC browser (- strand)
72% to 2j6 mouse, frag y in fig below
116604392 LYNIFPWIMNYGPGSHQ 116604342 116604222 exon 5
116604345 SVFRNWEKLKLFVSCMIDNKQRWVP 116604271 exon 5
116602255 YPEKSTSFSQGHLFCSTLNLFRAGSET 116602175 exon 6
116591992 GKRACPGEQMAISELFSFFAAFMQ 116591921 exon 9
116591919 KFTFHLAINEKLRMKFRNGLTLP*SSHLYC 116591830 exon 9
rat, mouse and human 2J cluster
CYP2J17P rat
UCSC browser (- strand)
116584536 MLATASCLVANVCSAIPLWTLLLAALSWLPQKQAPQKQPSRALAPAIFGNLFQFDLDVSQLHSGI*PSKK 116584327 exon 1
116581102 FVTKYGNLISLDFGNTSSVIISGLPLIKEALTDM 116581001 exon 2
116580637 EQNLLKCIVLASREHVFKNN 116580578 exon 2 last half
116570454 LYNVFPFIIKYL 116570419 exon 5
116570408 NQTFFRNWENLNLFVSHMMESHRKDWNPVEPRDFIDAFLTYMTKEDD 116570268 exon 5 last half
116566151 KVHSEIDGVTGHGRPPSTGDRDSMPYTNAVIYEVLRMDNINPLKVPREVTADSTLDEFCLSK 116565966 exon 7
116563406 GTMVLINLTALYRESKEWTTQDTFNPEHFLENGMFKKRESF 116563284 exon 8
116559748 KFTFKPPISEKLSLKFRTGLTLSHVSCRI*SIHR 116559647 exon 9
CYP2J18P rat
UCSC browser (- strand)
63% to 2j6 mouse
116551335 MLGTQDILEAGIWALLH 116551285 exon 1
116551282 RTLLLAAVTFLLLADYLKTGNK 116551217 exon 1
116551217 KKYPWGPCNPPVMNNLFQLDLEQ 116551149 exon 1
116537661 LYNAFLSIMKYHPGSHQ 116537611 exon 5
116537614 SVFRNWEKLIWRMSHIAENHCKG*NPAEL 116537528 exon 5
116537523 REFIDAFLTKMTK 116537485 exon 5
116534551 YPDKTTTNFNEENLICA 116534501 exon 6
116534498 LEFLFARTEITSTTLSWVLLYLSANPGVQ 116534412 exon 6
116529361 LFIFFTSLMQKFTFKPPISEKLILKFRMGLILSPVCH*ICVVPRQ* 116529224 exon 9
Cyp2jbbpX mouse
XM_143896
Map view locus LOC230464
exons 3-4 and exon 9
temporary placeholder name for Cyp2j14-ps
Cyp2jzzpX mouse
Map view locus LOC230460
3 C-term fragments ABOUT 19KB APART
temporary placeholder name
note this is an old name for Cyp2j7-de9b, Cyp2j7-de9c, Cyp2j7-de9d
CYP2J19 Gallus gallus (chicken)
NW_060417.1 weakly like a CYP2J, 52% to 2J2 human
BI390850.1 EST all the best hits are CYP2Js
12644 MDFRFWPISQLGKLNVSMLLVVLVMFLLIIDFVRKRRPRNFPPGPQLFPLVGTIVDLRQPLHLEMQK 12444
10910 LTARYGNIFSVQFGGLTFVVVSGYQMVREALVHQAEIFADRPHIPLLQEIFRGF 10749
10125 GLISSNGHIWRQQRKFVSATLKSIAVSFESKVQEESRYLVEAMEEEK 9985
8514 GQPFDPHYKINSAVSNIICSITFGNRFNYHDSNFQELLHLLAETLLLIGSFWGQ 8299
7615 LYNAFPLIMRWLPGPFRKIFRHWEKLQRFVRGVIAKHKEDLDQSDLGDYIDCYLKEIEK 7439
7077 CKGDTNSYFHEENLLCSTLDLFLTGTETTATAIRWALLYMAAYPHIQ 6937
6401 EKVQLEIDAVIGQCRQPTMEDKEHMPYTSAVLSEVLRMGNIVPLGVPRMSTNDTTLAGFHVPK 6213
5285 GTTLMTSLTSIMFDKNVWETPDTFNPEHFLENGQYRRREAFLPFSA 5148
4669 GKRACPGEQLARTELFIFFTALLQKFTFQAPSATVLSFAFTLSLTRCPKPFQLCALPR 4496
CYP2J20 Gallus gallus (chicken)
NW_060417.1 weakly like a CYP2J, 52% to 2J2 human
This sequence joins with the rest of the gene on
NW_060416.1|Gga8_WGA225_1
joined by EST BI064782.1
(part of a 6 gene CYP2J cluster)
1641 MLRFLWDSISLQMLFIFLLVFLLVSDYMKRRKPKDFPPGPFSFPFLGNVQFMFAKDPVVAIQK 1453
943 FIEKHGDIFRTQVGSMSFVIVNGLPLIKEALVTQGENFMDRPEFPTNTEFFNKF 782
574 GLVSSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ 425
GNPFNPHLKVNNAVSNIICSVTFGNRFEYHDEDFQNLLRLMNETAILQGKIMSQ
15531671 LYNFFPSVIKYFPGSHQTVIKNGRLMKRFVCKKISKHKEDLSPSESRDFIDSYLQEMAK 15531495
15531239 PNGRDFCEDNLVACTLDLFFAGTETTSTTIRWALLYMAIYPEIQ 15531108
15530636 ARVQAEIDAVIGQARQPSLEDRSNMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFRVPK 15530448
15529975 GTILIPNLSSVMFDMKEWETPHSFNPGHFLKDGQFWKREAFMPFSI 15529838
15529096 GKRACLGELLARAELFLFFTALLQKFTFQAPPDTILDLKFTHGMTLAPQPYMICAVPR 15528923
CYP2J21 Gallus gallus (chicken)
NW_060416.1|Gga8_WGA225_1
(part of a 6 gene CYP2J cluster)
15526022 MLRFLWDSISLQMLFVFLLVFLLVSDYMKKRKPKDFPPGPFSFPFLGNMEFIIAKDPVAVTEK 15525834
15525310 FIEKHGDIFSTQVGSMSFVIVNGLPLIKEALVTQGENFMDRPEFPINTEFLNKF
15524941 GLVFSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ 15524792
15523650 GNPFNPHLKVNNAVSNIICSVTFGNRFEYHDEDFQNLLRLMDETVTLQGEPMSQ 15523489
15522627 LYAFFPSIIKYFPGSHQTVLKNEKLMKRFVCKKISKHKEDLSPSESRDFIDSYLQEMAK 15522451
15522209 KPNGSDFCEDNMVSCTLDLFFAGTETTSTTIRWALLYMAIYPEIQ 15522075
15521605 ARVQAEIDAVIGQARQPSLEDRSNMPYTNAVIHEVQRKGNIIPFNXXXXXXXXXXXXXXXXXX 15521471
15521289 XXLLIPNLSSVMSYKKQWETPHSFNPGHFLKDGQFWNREAFMPFSI 15521158
15520424 GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDLKFTVGITLAPQPYKICAVPR 15520251
CYP2J22 Gallus gallus (chicken)
NW_060416.1|Gga8_WGA225_1
(part of a 6 gene CYP2J cluster)
15518269 MLRFLWDSISLQMLFVFLLVFLLVSDYMKKRKPKDFPPGPFALPFLGNVQLMVAKDPVSTVQK 15518081
15517552 XXEKHGDIFSMQVGSMSFVIVNGLQMIKEALVTQGENFMDRPEFPMNAEVFNKF 15517403
15517205 GLLSSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ 15517056
15515960 GNPFNPHLKINNAVSNVICSITFGNRFEYHDEDFQNLLRLMDETVTLHGKIMSQ 15515799
15514587 LYTFFPSIVKYLPGSHQTVIKNGKLMKDFVCNVISKHKEDLNPSESRDFIDSYLQEMAK 15514411
15514166 PDSSDFCEDNLVSCTLDLFFAGTETTSTTIRWALLFMAMYPEIQ 15514035
15513576 ARVQAEIDAVIGQARQPSLEDRNNMPYTNAVIHEVQRKGNIIPFNALRLTVKDTVLAGFRVSK 15513388
15512873 GTILIPNLSSVMYDKKEWETPHSFNPGHFLKDGQFWKREAFMPFSI 15512736
15512011 GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDFKFTMGITLAPRPYKICAVPR 15511838
CYP2J23 Gallus gallus (chicken)
NW_060416.1|Gga8_WGA225_1
(part of a 6 gene CYP2J cluster)
15510424 MLRFLWDSISLQMLFVFLLVFLLVSDYMKRRKPKDFPPSPFSFPFLGNVQFMFAKDPVVATQK 15510236
15509668 XXEKLGDIFSMQAGSQSFVIVNGLPLIKEALVTQGENFMDRPEIPLDTDIFSKL 15509519
15509300 GLISSSGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTEAFRDEQ 15509151
15508915 GNPFNPHLKINNAVSNIICSVTFGNRFEYHDENFQTLLRLMDETVTLHEKIMSQ 15508754
15508232 LYNAFPSIVKYLPGSHQTIFKNWRLMKDFVNEKISKHKEDLNPSESRDFIDSYLQEMAK 15508056
15507812 PSGSEFHEENLVACALDLLFAGTETTSTTIRWALLFMAVYPEIQ 15507681
15507221 AHVQAEIDAVIGQARQPALEDRNNMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFRVPK 15507033
15506561 GTILIPNLSSVMYDKKEWETPHSFNPGHFLKDGQFWKREAFMPFSI 15506424
15505718 GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDFKFTMGITLAPRPYKICAVPR 15505545
CYP2J24P Gallus gallus (chicken)
NW_060416.1|Gga8_WGA225_1
(part of a 6 gene CYP2J cluster)
15504220 DSMKRQWLNFFKSIVGQQQLHCADYMKRRKPKDFPPSPFSFPFLGNV*FMFAKDPVVATQK 15504038
15503534 IIEEHGDIFSMQVGTQSFVIVNGLPLIKEALVTQGENFMDRPEIPMNAEVFSKL 15503385
15503168 GLLSSNGHL*KQQRRFTLTTL*NLGLGKRSLEERIQKECQFLTDAFRDEQ 15503019
15501515 GNPFNPHLKVNNAVSNVICSITFGNWFEYHDKDFQNLLQLMDETATFYGKIMNQ 15501354
gap
15501024 PNGSDFCGDNLVLCTLDLFFAGTETTSTTIRWALLFMAIYPEIQ 15500893
gap
15498733 GKRACLGELLARVEIFLFFTSLLQKFTFQAPPDTILDVKFTMGITLAPQPYKICAVPR 15498560
CYP2J25 Phalacrocorax carbo (Common cormorant)
No accession number
Hisato Iwata
submitted to nomenclature committee 5/19/05
78% to 2J23, 76% to 2J22, 70% to 2J21, 75% to 2J20
55% to 2J19
CYP2J26 Bos taurus (cow)
See cattle page for details
MLEALGSLVAALWTTLRPGIVLLGAFVFLLFADFLKRQHPKNYPPGPLRLPFIGNFFHLDLGKGILVPQQ
VVKKYGNIIRLDFGVIHFIVITGLPYIKEALVNQEQNFVNRPMIPLQKHIFNNK
GLVRSNGQVWKEQRRFTLTTLRNFGLGRKSLEERIQEEVTYLIQAIGEEN
GQPFDPHFIINNAVSNIICSITFGERFDYKDDQFQELLRLLDEILCIQASVCCQ
LYNAFPRIMNFLPGSHHTLFRKWEKLKMFVANVIENHRKDWNPAEARDFIDAYLQEIEK 11676
HKGNATSSFDDENLICSTLDLFLAGTETTSTTLRWGLLFMALNPEIQ 14705
EKVQAEIDRVLGQSQKVSTASRESMPYTNAVIHEVQRMGNIVPMNVPREVTVDTVLAGYH 15236
LVKGTMVLTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSI
GKRMCLGEQLARTELFIFFTSLLQKFTFRPPENEKLSLKFRESLTSSPASYRLCAIPRA* 25310
CYP2J27 Bos taurus (cow)
See cattle page for details
MLEALGSLAAALWAALRPGTVLLGAVVFLFLDDFLKRRRPKNYPPGPPPLPEVGNFFQLDFDKAHLSLQR
FVKKYGNVFSVDFGIFRSVLITGLPLIKEALVHQDQNFANRPLIPIEKRIFNNK 37352
GLIMSNGHVWKEQRRFALTTLRNFGLGKKSLEERIQEEAAYLIQEIGEEN 39667
GQPFDPHFTINNAVSNIICSITFGERFDYQDDQFQELLRLFDEMMHLRTSTCCQ 40221
LYNIFPRIMSFLPGPQHALFSKWEKLKMFIAGVVENHKRDWNPAEARDFIDAYLQEIEK 42145
HKGNATSCFHEENLIYNTLDLFFAGTETTSTTLRWGLLYMALYPEIQ 43949
EKVQAEIDRVLGQSQKPSMAARESMPYTNAVIHEVLRMGNILPLNVPREVTVDTVLAGYRLPK
GTMVTTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSI
GKRMCLGEQLARTELFIFFTSLLQKFTFRPPENEKLSLKFRMSMTLSPLSHRLCAIPRA*
CYP2J27-ie5b Bos taurus (cow)
See cattle page for details
extra internal exon 5
LSNVFPRIMNFLPGPQHTLFSKWEKLKMFIAGVIENHKRDWNPAEARDFVDAY 41591
CYP2J28 Bos taurus (cow)
See cattle page for details
MLEALGSLAAALWAALRPGTVLLGAIVFLLLTDLLNRRRPKNYPPGPPRLPFVGNFFQLDFEQGHLSLQR
FVKKYGNLFSLEFGDLPSVVITGLPLIKEVLVYQDQNFVNRPISPIRERVFKKN
GLIMSNGHIWKEQRRFSLTALRNFGLGRKSLEERIQEEVAYLIQAIGEEK
GQPFNPHFKINNAVSNIICSITFGERFDYQDDQFQELLRLLDEVTYLETTVWCQ
LYNVFPRIMNFLPGPHQMLFSNWRKLKMFVARVIENHKRDWNPAEARDFIDAYLQETEK
HKGNAASSFHEENLIYNTLDLFFAGTETTSTTLRWGLLYMALYPEIQ 716
EKVQAEIDKVLDESQQPSMATRESMPYTNAVIHEVQRMGNILPLNVPREVTVDTVLAGYHLPK
GTMVLTNLTALHRDPAEWATPDTFNPEHFLENGQFKKREAFLPFSI
GKRMCLGEQLARTELFIFFTSLLQKFTFRPPEHEELSLKFRMGLTLSPVSHCLCAVPRA*
CYP2J29 Bos taurus (cow)
See cattle page for details
MLSSLAAALWAALRPGTVLLGAVAFLFFADFLKRRRPKNFPPGPAGLPFVGNSFQLDPEKVHLTLQQ
FVKKYGNVFSLDFGTFPSILITGLPLIKEALVHQGENFSKRPVMPLQERIFNTK
GLIMSSGHIWKEQRRFALTTLRNFGLGKKSLEERIQEEASYLIQMIREEN
GKPFDPHFIINNAVSNIICSITFGERFDYQDSQFRELLRLLDEVLNLHTSLCCQ
LYSVFPRIMNFVPGPHQTLFSNLEKLKMFVAEMIENHKRDWNPAEARDFIDAYLQEIEK 8435
HKGGDASSFREENLIYSTLDLFLAGTETTSTSLRWGLLYMALNPEIQ 5634
EKVQAEIDRVLGQSQQPSTAARESMPYTNAVIHEVLRMGNIIPLNVPREVAVDTTLAGYHLPK 5455
GTVVVTNLTALHRDPAEWATPDTFNPEHFLENGQFKKRESFLPFSI 2548
GKRMCLGEQLARAELFIFFTSLLQKFTFRPPENEKLSLKFRVSLTLAPISHRLCAVPRG*
CYP2J30 Bos taurus (cow)
See cattle page for details
MLEALSSLATALWAALRPDTVLLGTLAFLLFVDFLKRRHPKNYPPGPPGLPFVGNLFQLDPEKVPLVLHQ
FVKKYGNVFSLDFGTVPSVLITGLPLIKEVLVHQGQIFSNRPIVPLQEHIINNK
GLIMSSGQLWKEQRRFALTTLRNFGLGKKSLEERIQEEASYLIQTIREEN
GQPFDPHLTINNAVSNIICSITFGERFDYQDDQFQELLRMLDEILNLQTSMCCQ
LYNVFPRIMNFLPGPHQALFSNMEKMKMFVARMIENHKRDWNPAEARDFIDAYLQEIEK
HKGDATSSFQEENLIYNTLDLFLAGTETTSTSLRWGLLFMALNPEIQ
EKVQAEIDRVLGQSQQPSMAARESMPYTNAVIHEVLRMGNIIPLNVPREVAVDTTLAGYHLPK 15084
GTMVMTNLTALHRDPTEWATPDTFNPEHFLENGQFKKRESFLPFSI 12265
GKRMCLGEQLARTELFIFFTSLLQKFTFRPPENEQLSLKFRVSLTLAPVSHRLCAVPRG*
CYP2J31P Bos taurus (cow)
See cattle page for details
MGAAAFLFVVHLKRRRGKNYPPGPPGLPFLGNFFHLDLKQLHLSLQQ
IVKKYGNMISLEMGGFSTVFFKWIAQNQRSPCLPGPKLVNHPIQRIQENIFKKH 5343
GLIMSNGHIWKEQRRSALTTLRNFGLGRKILEECIQEEAAYLIQTVGEEN 8001
XQPFDPHFTINNAVSNIVCSIAFGELFDYQDSXXQELLRLMDEAMYLQTSVRCRV 8538
LYNFFARIMNFLPGPHQTLFIKWEKLNMFIDSVIENHRRDWNPAEPRDFTDA
15856 GMWMCPGEQLARTELFIFFTSLLQKFTFRPPGDEKLSLQFRVSLTISSVSHWLC 16020
CYP2J32v1 pig
BW982013.1 CB287444.1, Z84061.1, BE014607.1
97% to CJ016505.1, 80% to 2J27 cow,
ALGSLAEALWTALRPSTILLGAVAFLFFADFLKKRRPKNYPPGPPRLPFIGNLFHLDLDK
GHLSLQRFVKKYGNVFSLDFGALSSVVITGLPFIKEAFVHQDKNFSNRPIVPIQQRVFKD
KGVVMSNGQVWKEQRRFALTTLRNFGLGKKSLEERIQEEAQYLIQAIGEENGQPFNPHFK
INNAVSNIICSITFGERFDYQDNQFQELLKLLDEVMCLQTSVWCQIYNIIPWIMKFLPGP
HQTLFSNWEKLKMFVAHVIENHRRDWNPAEARDFIEAYLQEIEKHTGDATSSFQEENLICS
TLDLFVAGTDTTSTTLRWGLLYMALYPEIQEKVQAEIDRVLGQLQQPSSSARESMPYTNA
CYP2J32v2 pig
CJ016505.1
NRPTVPIQQRVFKDKGVVMSNGQVWKEQRRFALTTLRNSGLGKKSLEERIQEEAQYLIQA
IGEENGQPFNPRFKINNAVSNIICSITFGERFDYQDDQFQELLKLLDEVMCLQTSVWCQI
YNIIPWIMKFLPGPHQTLFSNWEKLKMFVAHVIENHRRDWNPAEARDFIDAYLQEIEKHK
GDATSSFQEENLICSTLDLFVAGTETTSTTLRWGLLYMALYPEIQEK
VQAEIDRVLGXLQQPSTAARESMPYTNA
CYP2J33 pig
BP170090.1 CK453810.1, BW982704.1, DB811462.1
DB817476.1, DY414727.1 DY418828.1 85% to CJ016505.1
80% to 2J28 cow
MTQALGSLAEALWTALHPSTLLLGAVTFLFFADFLKKRRPKNYPPGPLRLPFVGNLFHLD
FEKAHLSLQRFVKKYGNIFSLDLCALSAVVVTGLPLIKEVLVHQNQKFANRPILPIQDRV
FKNKGVVTSSGQVWKEQRRFTLTTLRNFGLGKKSLEERIQEEAQYLIQAIGEENGQPFNP
QFKISNAVSNIICSITFGKRFDYQDDQFQELLRLLREVTHLQTLLWCQLFNVFPRIMKFL
PGPHQTLFSDWEKLEMFIARVIENHRRDWNPAEARDFIDAYLQ
EIEKNKGNATSSFHEENLICSTLDLLFPG
TDTTLITLRWGLLYMALHPEIQEKVQAEIDRVLGQSQQPSTAARESMPYTNAVIHEVQRM
GNIIPLNVPREVAEDTTLAGYHLPKGTMVLTNLTAL
HRDPAEWATPNIFNPEHFLENGKFKKREAFLPFSIGKRACLGEQLARTELFVFFTSLLQK
FSFRPPDNEKLSLKFRVGLTLSPVTYCICAVPRA*
CYP2J34 pig
BW981916.1, CJ028862.1, BW967356.1, CJ025847.1, BP142154.1
BP168104.1, CJ025026.1, BW967863.1,
83% to BW982013.1, 80% to 2J28 cow
MTPALGFLAEALWTALRPSTLLLGAVAFLFFADFLKRRSPKNYPPGPPRLPFLGNFFHLD
VEKGHLALQRFVKEYGNIISLDSSVFSSVVITGLPLIKEAFVHQDQHFANRPMIPTQERV
FKKNGLIMSNGQVWKEQRRFALTTLRNFGLGKKSLEERIQEEAQYLIQAIGEENGQPFNP
HFKINNAVSNIICSITFGKRFDYQDDRFQELLRLLDEVTCQHTSVQVQLYNMFPRIMKFL
PGPHQTLFSNWEKLQIFVACVIENHKRDWNPAEARDFIDAYLQEIEKHKGNATSSFQEEN
LIFTTLDLFFAGTETTSTTLRWGLLYMALYPE
CYP2J35 pig
BW960287.1, BI359857.1
75% to 2J28 cow
MLGAVGFLAEVFGTALGPSALLLSAVAFLFVADILKRWRPKNYPPGPLRLPFVGNFLHLD
FEQWHLSLQRFVKKYGNVLSLDLGAFSSVVITGLPLIKEALVHQDQNFVNRPINLNQV
FQKNGLIMSNGQVWKEQRRFALTTLRNFGLGKKSLEERIQEEAQYLIQAVREENGQPFDP
HFKINNAVSNIICSITFGERFDYQDDQFQELLRLLDEVTCL
PKLVRVQLFNVFPRIMKLLPGPHQIIFSNREKLRMF
IARVIENHRRDWNPAEARDFIDAYLREIEKGSSPSVFNEENLICSTLDLFFAGTETTS
TTL
CYP2J36 Anolis carolinensis (anole lizard)
scaffold 23 3305369-3326894 (-) strand
(small gap in exon 8)
55% to CYP2J2, 43% TO CYP2C8
3358582 MWFHAFAIFWETISLQVILGFLATFLLLTDYVKRRRPRGFPPGPIPLPFLGNLLSYDAKKPHLYNQK 3358382
3357138 LVAIYGNVFSLQLGNIHIVFLNGLQAVKEALINQGESFLDRPKVPITYDVSKTF 3356977
3351644 GVITSNGQTWKQQRRFVMSTLRNFGLGKTYLEERIQEESRFLVAAIEDEK 3351495
3348890 GQPFDPYHQINNAVSNVICSVTFGNRFDYHDSDFQKLLHLLDETGVFLRNIWSH 3348729
3347734 LYNAFPSLMRRLPGPHQTYFKNWEQLKSFVRKIIEKHKEDWNPLKTKDFIDAYLNEMAK 3347558
3346355 FKENASSTFHMENLLQSTLDLFVAGTETTSATLHWAVLYMAVYPEIQ 3346215
3343877 AKVQAEIDSVIGQSHLPAMADRDNMPYTNAVIHEIQRRSSIVVVNAPRLTANDTQVAGFHLPK 3343689
3337326 xxxxxxxLTSILFDKNEWETPNVFNPNHFLKNGQFMKREAFVPFST 3337210
3335618 GKRACPGEQMAKMELFLVFTTLLQKFTFQAPKGVKLSLDSKTGHVLKPKPYQICAISR* 3335442
CYP2J37P Anolis carolinensis (anole lizard)
scaffold 23 3305369-3326894 (-) strand
pseudogene
57% to CYP2J2, 43% TO CYP2R1
3326894 MLCHCFAVFWEALSLKIVFVFLFTFLIIADYIRQRRPRGFPPGPRPLPFVGNLFSVDITKPHLSSEK 3326694
3325276 FMEIYGKIFSLQLGKFPFVIVNGLQLVKEALIHQNENFVDRPILPIIYDHSKTF 3325115
3322787 GLIMSNGLSWKQQRRFALSTLRNFGLGKRSLEEQIQEESRFLVGAIEDEK 3322638
3320225 GQPFDSHYQINNAVSNVICSVTFGKCFDYHDSQFQKLLHLLDEMGNVQAGFWGM 3320064
3309149 AYNTFPALMKLLPGPHQTVFKNWDQLKSFVRKIIEKHQNWNPLETRDFIDAYLNEIAK 3308976
3308595 LKD*ASSSFHMENLLQ*TIDLFIAGTETETTSATLRWAVLYMAIYPDIQ 3308449
3307295 GKVQAEIDSVIGQSRSLTMADRDSLPYTNAVIHEIQRMGNILPFSAPRVAVNDTRLAGFYLPK 3307107
3305985 GTILLPNLTSLLFDKDEWDTPNKFNPNHFLKDGQFMKREAFIPFSI 3305848
3305545 GKRSCLGEQLARMELFLFFTTLMQKFTFQAPNGLRLSLDFKIGNALSPKPYKICAISR* 3305369
CYP2J38 Anolis carolinensis (anole lizard)
scaffold 23 3277211-3297585 (-) strand
57% to CYP2J2, 43% TO CYP2C18
3297585 MLFHCFAVFWETLSLKAVLVFLATFLIVADYVRRIHSRGFPPGPMPLPFVGNLLHLDAEKPHFSTQK (0) 3297385
3295355 LADIYGNVFSLQLGNRHFVFVNGLEIVKEVLIHHGENFLDRPKFPIISDHAKTL 3295194
3294395 GLVMSNGLPWKQQRRFALSTLRNFGLGKRSLEERIQEESRFLAGAIENEK 3294246
3288794 GQPFDPHYQINNAVSNVICSITFGNRFDYHDSQFQKLLHLLNETGIIQRSIWAQ 3288633
3286768 LYNIFPALMKQLPGPHQTIFKNWEQLKYFVRTIIKKHQENRNPLETRDFIDAYLNEMTK 3286592
3285518 FKENVSSSFHMENLLQSALDLFIAGTETTSTTLRWALLYMAIYPEIQ 3285378
3282591 ERVQSEIDSVIGQSRPPAMTDRDNLPYTNAVIHEIQRISNILPLNVPRLTTNNTEIAGFHLPK 3282403
3280566 GTILICNLTSVLFDKDEWDTPKKFNPNHFLSNGQFRIREAFVPFSA 3280429
3277387 GKRACLGERLARMELFLFFTALIQKFSFQAPKGVELSLDFKMSLTLSPNQYHICAVSR* 3277211
CYP2J pig
BF191621.1, BX914614.2, BQ601924.1
85% to 2J30 cow
possible end of 2J34 or 2J35
GQSQQPSIAARECMPYTNA
VIHEVQRMGNIIPMNVPREAAEGTTLAGYHLPKGTMVLTNL
TALHRDPAEWTTPDRFNPEHFLENGQFKKREAFLPFSIGKRACLGEQLARTELFVFFTSL
LQKFTFRPPDNEKLSLKFRMGLTLSPVTYRICAVPRA
2K Subfamily
CYP2K1 Onchorhynchus mykiss (rainbow trout)
GenEMBL L11528 (1853bp) PIR S45644 (504 amino acids)
Buhler,D.R., Yang,Y.-H., Dreher,T.W., Miranda,C.L. and
Wang,J.-L.
Cloning and sequencing of the major rainbow
trout constitutive cytochrome P450 (P450 2K1): Identification
of a new P450 gene subfamily and its expression in mature
rainbow trout liver and trunk kidney.
Arch. Biochem. Biophys. 312, 45-51 (1994)
CYP2K1v2 Onchorhynchus mykiss (rainbow trout)
GenEMBL AF045052
Buhler,D.R.
note: 98.6% identical to 2K1 may be an allele (5L1FL)
submitted to nomenclature committee
CYP2K1v3 Onchorhynchus mykiss (rainbow trout)
GenEMBL AF045053
Buhler,D.R.
note: 98.4% identical to 2K1 may be an allele (5L6FL)
submitted to nomenclature committee
CYP2K2 Fundulus heteroclitus (killifish)
John Stegeman
submitted to nomenclature committee
CYP2K3 Onchorhynchus mykiss (rainbow trout)
GenEMBL AF043551
Buhler,D.R.
(5L7FL) 96.5% identical to 2K1
CYP2K4 Onchorhynchus mykiss (rainbow trout)
GenEMBL AF043296
Yang,Y.-H., Andersson,T.B., Ryu,B.-W., Wang,J.-L. and Buhler,D.R.
CYP2K4: A New Cytochrome P450 Isoform from Male Trunk Kidney of
Post-Spawning Rainbow Trout.
Unpublished
kid8 from kidney
CYP2K5 Onchorhynchus mykiss (rainbow trout)
GenEMBL AF151524
Buhler,D.R.
80% identical to 2K1
clone name KM2-2 from sexually mature male trunk kidney library
CYP2K6 Danio rerio (zebrafish)
No accession number
Wang-Buhler, J.L., Yang, Y.H., Lee, S.J. and Buhler, D.R.
Submitted to nomenclature committee 6/16/2000
CYP2K7 Danio rerio (zebrafish)
GenEMBL AI722500 EST 88% to CYP2K6
Full length translation of this EST allowing framshifts
INNLFGAGXDTTVTTLRWGLLLFAKYPEIQAKVHDEIDSVIGERQPVPDDRKNLPYTDAVIHEIQRFADILPIG
LLRQTSCDVHLNGYLIKKGTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGES
LARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKRF*
CYP2K7 Danio rerio (zebrafish)
No accession number
Donald R. Buhler
EST AI722087 fd19b07.y1, AI722500 fd19b07.x1, BF157099 fl60g01.y1
Submitted to nomenclature committee 2/10/2001
503 amino acids, 76% to 2K6, 59% to CYP2K4, CYP2K5
CYP2K8 Danio rerio (zebrafish)
No accession number
Yea-Huey Yang, Jun-Lan Wang-Buhler and Donald R. Buhler
EST 78% to CYP2K5 clone name F2R
Submitted to nomenclature committee 7/1/2000
CYP2K9 Fugu rubripes (pufferfish)
No accession number
Scaffold_12487
3037 MIEDLFESSTSGFLMVAIVSLLLLQ
LCFSFISREKRKDLPGPEALPLLGNLHQLDLKRLDCHLVQ 3231 (0)
3299 LSQKYGPIFRVYLASKKVVVLAGYTAVKQALVNQAEDFGEREIFPIFHDFNKGN 3460 (1)
3527 GILFTNGDQWKEMRRFALMTLKDFGMGKRTIEEKIIKECQYLIEAFEQHQ 3676 (1)
GEAFSNAQVISYATSNIISAIMYGRRFDYKDPTFQAMIERDHEVIHLTGSPSIQ (0)
IYNIFPWLGPFLKTWRYIMKKVEINIESTRRIIGEMKETRNP
GTCRCFVDAFLIHKENQE (0)
4483 ESDVNAHYYHEDNLLHCAMNLFGAGTDTTATTLQWGLLYITKYPHIQ 4623 (1)
4692 DGVQEELRRVVGNRQVRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTS*DTFQGYVIKK (0?)
GTMVIPLLTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSA 5095 (1)
5164 GRRMCLGEGLARMELFLFFASLLQHFRFKPAPGVSEDSLDLTPVVGITLNPLTHKLRAISRF* 5352
CYP2K10 Fugu rubripes (pufferfish)
No accession number
Scaffold_19693
296 SKKYGPVFKVHFGPRKVVVLAGHKTVKEALVGNAEQFGDRDISPIFYDMNQGHG 457 LKU76565.x1
missing exon 3 and part of exon 4
2727 YATSNIISSIVYGSRFDYDDPRFINMVNRVNEVIRLTGSAPIQ (0)
LYNIFPGLANWIKNRQLLLKQVAMNLRDMTDLIQQLKDTLNPGVCRGFVDCFLLRKQKAV (0)
2184 DSGVIDSLYNEKNLLYSLSNLFGAGTDTTATTLRWGLLLMAKYPRIQG
QVQQELSMVVGNRRVCVEDRKNLPYVDAV 1813
1812 IHEIQRLGNIAPMAVPHKTARDVEFRGYFIEK 1717
1286 GTTVFPLLTSVLYDENEWETPHTFNPSHFLDKDGKFIKRDAFMPFSA 1146
1063 GRRLCLGEGLAKMEIFLFFTSLLQQFRFTPPPGVGEDELDLTPVVGFTLSPSPHKLCAIPRQ*
CYP2K11 Fugu rubripes (pufferfish)
No accession number
Scaffold_10791
missing exons 1-4 about 176 aa
5891 VYDLFPWIGPLVNNKKLFQSLFAANKKQNLQLFAAAKEMLNPQMCRSFVDSFLARQQILE 5721 (0)
4989 KSGTNVHFHDENLMSTVMNLFNAGTDTTATTLRWGLLLMAKYPLIQ (1?)
4750 DQVQEELRRVIGSRQVQVEDRKSLPFTDAVIHETQRLANIVPMALPHKTSQDVTLQGFFIEK 4571 (0)
GTTVYPLLTSVLYDETEWEKPLNFYPAHFLDKDGKFVKREAFLPFSA 4355 (1)
4287 GRRICLGEGLAKMELFIFFSTLLQHFRFRPPPGVSEDHLDLTPRVGLTLNPSAHKLCAVSCL* 3999
CYP2K12P Fugu rubripes (pufferfish)
No accession number
Scaffold_3103 Length = 27036 59% to scaf 10791
Heme junction missing the conserved Gly, no uspstream seq found
With these defects and a frameshift this is probably a pseudogene
LKB99171.x1 50% TO 2C37
17897 DQVQEELSRVIG 17862 frameshift
17860 SRQVQEGDRKNLSFTNAVIHETQSGHVALTSLPHVTNQDIIFRGHFLKKG 17711 (1)
17388 NYMEDTASVASVLLEETEWEHPHTFYPSHFLEKDRKFVKRDAFLPFSA 17242 (1)
17176 ISRACPGETLARVELFIFLVTLLQHFCFTLAPGVSPDELHVTPSIGSNHSPVAYRLCTVSCM* 16988
CYP2K13P Fugu rubripes (pufferfish)
No accession number
Scaffold_12487
pseudogene frag of 2K9
660 VRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSXX frameshift
RHLPGIRHQK
CYP2K14P Fugu rubripes (pufferfish)
No accession number
Scaffold_13436b Length = 4942
pseudogene of 2K9
= LGW56404.x1 50% to 2A7
two partial genes in this contig both on minus strand
Scaffold_13436b pseudogene of Scaffold_12487 (fs) = frameshift
3958 VRVEDRKNLPYMEAVIHETQRMANIVPMSLPHRTSRD (fs) RHLLX (fs) GIRH (fs) QK (1?)
alternative frame RDTSFSGDTSSKRFTALFELAHVYV
GTMVIPL (fs) LTSVLYDESQWEKPHTFNPAHFLDDEGRFVRRDAFMPFSA (1)
GRRMCLGE (deletion 3 nuc) RMELF (insertion 12 nuc) LFF (deletion 33 nuc)
VSVDSLDLTPVVGITLNPLTHNLRAISRF* 3368
CYP2K15P Fugu rubripes (pufferfish)
No accession number
Scaffold_13758
pseudogene
41% to LKB99171.x1 50% TO 2C37 Length = 5303
FC:C094J16aF1, FC:C007E01aF1 pseudogene
740 KGRITQRHFHDEKLMMTVSSHLAAGTHLDTYTALRQEPLVMAK*PEVQ 883 exon 6 (1) 52% to 2K11
Exons 7 and 8 deleted
1284 (1) GLRSCPGEG*SRMKLFIFIVILLQHLCFSSSPVLMEEDLELKTVLGSILNPINCVLFVGRER* 1472 exon 9 48% to 2K9
CYP2K16 seq.c Danio rerio (zebrafish)
ctg12742 68% to 2K8
57491 MAFLDALLHVSSTGTLICFLLLLLVAYLLFLRSQSDENEPPGPKPLPLLGNLLMLDVNKPHLSLCE 57294
52779 MAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFHDFTKGH 52618
52022 GIIFANGESWREMRRFALTNLRDFGMGKKKIEEKIIEETCHLREEFEKFX 51876
50840 GKPFETAQLMNYAASSVISSIVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQ 50679
50581 LYNMFPFLGPLLKNWRQLMKNLHLDIEEISELVNGLHQTLNHQDLRGFVDSFLVRKQX 50411
50317 DQDSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQ 50171
43796 DRVQEEIDQVIGGRQPVSEDRKNLPYTDAVIHETQRLANIVPMSIPHMTSSDITFNGYFIKK 43614
43440 GTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMPFSA 43300
42178 GRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVGFTLNPIAHKLCAVKR 41996
CYP2K17 seq.d Danio rerio (zebrafish)
ctg12742 BI427723 zfishC-a1846d04.p1c zfishC-a1146b02.p1c
66780 MAVVESLLHFSSAGTLLGTLLLLLVFYRLSRDSEFQKKRKDPPGPKPIPLLGNLLTLDLSRPFDSLCE 66577
63586 LSKTYGNVYQVFLGPKKVVVLIGHKTVKEALVNYADEFGERDITPIFRXXXXXX 63443
63238 GILFSNGESWKEMRRFAISNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX 63092
62992 GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRFTEMVDRANENIRVSGSVSMX 62834
62747 LYNIFPWLGLFLNSKRTVVRNMLKNRAEFMKLITGLQETLNIHDRRGFVDSFLIRKQX 62577
60380 XXXXGKKDSYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQ 60246
60158 XRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPMNLPHVTSCDVTFNGYFIKK 59976
59893 GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA 59753
59675 GRRVCLGESLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVGVTLNPSPHKLCAIKRF 59490
CYP2K18 seq.e Danio rerio (zebrafish)
ctg12742 MISSING FIRST TWO INTRONS EXON 3 IS DUPL. MAY BE A PSEUDOGENE
93% to 2K19, 91% to 2K21 zfishK-a1004a03.p1c (100% over 29aa) also matches 2K19, 2K20
78359 MAVVESLLQFASTGTLLGALLLFLVLYLVSSGSESQKEGKEPPGPKPLPLVGNLLTLDLTRPFDT 78165
78164 FFKLSKTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYAEEFGDREIGPGFSIMNDEH 77912
77911 GILFSNGENWKEMRRFALSNLADFGMGKRRSEEK
75750 GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKF 75604
75522 GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMX 75364
75253 LYDIFPWLGPFLKNKRIIVENIIQSRVQMTKLITALLETLNPNDPRGFVDSFLIRKXX 75086
74916 XQKSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQ 74773
74686 XRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK 74504
74413 GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVRRDAFMPFSA 74273
73457 GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR 73275
CYP2K19 seq.f Danio rerio (zebrafish)
ctg12742 91% to 2K21 AF221128 (1 aa diff) zfishC-a678c11.p1c (near perfect)
90000 MAVVESLLQFASTGTLLAALLLFLVLYLVSSGSQKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFE 89803 (0)
89722 LSKTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYAEQFGDREIGPGFRIMNDEH 89561 (1)
89232 GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFE 89086 (1)
89004 GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSVSMW 88843 (0)
88707 FHEMFPWVGPFLKSKRIIVENIIQSRAQMTKLITALLETLNPNDPRGFVDSFLTRKLSDE 88528 (0)
88365 KSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQ 88225 (1)
88137 DRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHKTTSDITFNGYFIKK 87952 (0)
87861 GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFIPFSA 87721 (1)
84188 GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRRS* 84000
CYP2K19 Danio rerio (zebrafish)
GenEMBL AL919697
Tseng, H.-P., Wang-Buhler, J.-L., Hu, C.-H.,
Hseu, T.-H., Peng, J.R. and Buhler, D.R.
Submitted to nomenclature committee Oct. 14, 2004
JR8
CYP2K20 seq.g Danio rerio (zebrafish)
ctg12742 88% to 2K19 and 2K21 zfishC-a1699d01.q1c (100% over 57aa)
AF221128 (1 aa diff) zfishC-a678c11.p1c (near perfect) zfishC-a1101c09.q1c (100% over 39aa)
104280 MAVVESLLQFASTSALLGALLLLLVLYLASSGSTSQKEGKEPPGPKPLPLVGNLLTLDLTRSFDTFFE 104077
103997 LSKTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYAEVFGDREIGPGFKXXXXX 103854
102358 GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX 102212
102123 GKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRFTEMVARANENVRVGGSFSMX 101965
101852 IYNIFPWLGPFLKNRAVVVKNITQNRAEKKKLITALLETLNPHDPRGFVDSFLIHKXX 101685
101522 XQKSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQ 101379
101300 DRVQEEIDRVIGGRQPVVDDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK 101118
97108 GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA 96968
92153 GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDALDLKGIVGITLNPSPHKLCAIRR 91971
>CYP2K21 seq.h Danio rerio (zebrafish)
ctg12742 91% to 2K19 zfishB-a619a12.q1c (near perfect)
112093 MAVVESLLQFASTGTLLGALLLFLVLYLVSSGSGSQKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFE 111890
111821 LSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFRIMNDXX 111666
109983 GIVFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX 109837
109744 GKPFDTTEPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMX 109586
109441 LYNMFPWLGPFLKNKRIVVRNIIQSRAQMTKLITALLETLNPNDPRGFVDSFLIHKXX 109274
109110 XQKSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLMAKYPQIQ 108967
108879 XRVQEEIDRVIGGRQPAVEDRKKLPYTDAVIHEIQRFANIVPLNLPHTTSCDITFNGYFIKK 108697
108484 GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA 108344
107905 GRRICLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR 107723
>CYP2K21-de1 seq.i Danio rerio (zebrafish)
ctg12742 PSEUDOGENE PARTIAL EXON 1?
113358 MAAVETLLQFASTGSLLSALLLLLVWYLVSSESTYQKKGKEPPGPKPLPLLGNLLT 113191
>CYP2K22 Danio rerio (zebrafish)
ctg11670 zfishC-a643a08.p1c MISSING EXON 6 GREATER THAN 95% to 2K7. 9aa diffs
in the first exon, only 3 aa diffs in the rest
33920 MALVAALLPGLGFTVSTILAFLLLFLVISYFFSSKDKGKYPPGPKPLPVLGNLHILDLKNTYMSLWK 34120
37393 LSKQYGPVYTVHMGPRTVVVLSGYKVVKEALVNLSEEFGERDISPIFQDFNEGY 37554
37635 GIVFSNGENWKEMRRFALSNLRDFGMGKKRSEELITEEIKYLKEEIERFX 37781
39367 GKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQ 39528
42486 LYNMFPWLRLFVANQKRVVDNVQESFKQIGEIVNGLKKTLNPQSPRGIVDKFLIQQQK 42659
45851 AKVHDEIDSVIGERQPVPDDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLNGYLIKK 46036
46115 GTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGA 46255
49040 GRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKRF 49225
CYP2K23 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XI (-) strand 9794341-9797707
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
61% to Fugu 2K11, 65% to 2K10
MSLFGDFVVYLCSSTSTFLGAVVLLLVLYLVSNSLTRRELRKVPPGPSPLPLLGNLLQLDLKRPYVTLCELSKKH
GSVFTVYLGTSRVVVLAGYKAVKEALVNHREEFGDRDISPIFYDLNHGHGILFANGESWKEMRRFALTNLRDFGM
GKQLSEHKILEECQYLMEVFEKHQGTEFIYTASPVNYATSNIISAIVYGSRFEYNDPQFMSMVERSNESISVVGS
VQIQLYNMFPKLVSWTKKRQLLLNNLTRTVRDVKELILHLKDTLHPQFCRGLVDCFLIQMQKDEEARVNTHYNEK
NLIFTVTNLFSAGTDTTATTLRWSLLLMAKYPHIQDQVQEELSRVVGSRQVRVEDRRNLPYTDAVIHETQRLANI
VPLAIPHKTSRDVTFQGFFISAGTTVIPLLTSVLRDESEWESPNSFNPSHFLDTEGKFIRRDAFMPFSAGSRACP
GESLARMELFLFFTSLLQRFRFTPPPGVKEDDLDLTPAVGFTLTPSPHELCAVSCEGIQNEKII*
CYP2K24 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XI (+) strand 9720129-9723291
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
59% to 2K10
MLMLEDLFLSYVTVALMLVLMCILVSLFFRSKDKRREPPGPQPLPLLGNLLQMDLKRLDRSLVD (0)
LSKKYGSVFTVHLGPQKVVVLAGYKTVKQALVNHAVEFGERRIPQFGNDLMLSDSYR (2)
KGIFFANGESWKEMRRFALSNLKDFGMGR
KAAEDKIIEEIQYLIEVFERHE (1)
GQPFSTGQPMNYAVSNIICSIVYGSRFEYRDKDFKLMVDRANENIQLAGS
PSVLLFDMYPGIFHWASNRMRLKRNVFENHKRIKQLIGHLQETFNVELCRGFVDSFLAQKKKLEDSGITDSYYNI
ENLVSTVGNLFSGGTDTTSSTLRWGLLLMAKYPRIQYQVQEELSRVVGSRQVRVEDRRNLPYTDAVIHETQRLAN
VVPLAIPHKTSQDVTFQGFFIKGGTTVFPLLTSVHHDESEWESPNSFNPSHFLDTEGKFIRRDAFMPFSAGRRAC
PGESLARMELFLFFTSLLQLFRFTPPPGVKEDDLDLTPVVGFTLTPSPHELCAVSREGIQNE*
CYP2K25 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XI (-) strand 9676173-9679867
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
59% to Fugu 2K10, 52% to 2K8 Danio
MENLFLQLNSTTILLGTVGILLLLYVFLTNFDHKRKEPPGPRPLPLFGNLLHLNLKSFHMTLYELSKKYGSVFSV
HLGPQKVVVLAGYKTVKQALVNHAVEFGERYVSPTGHDLSNGIVFGNGESWKEMRRFALTNLRDFGMGKKAAEDK
IIEEIQYLFEVFDRHQGQPFNTGQSMNYAVSNIICSIVYGSRFEYSDEEFRLMVDRVNYNIRLAGSPSAKLFDMY
PWLFQWTSNRKRLTRNVTENRNQIKRLIGRLQETLNVHMCRGFVDSFLAHKQKLEDLKITDSHYNMENLVSTVSN
LFAAGTNTSGTTLRWGLLLMAKYPHIQGKVQEELSRVVGNRQVRAKDRMNLPFADAVIHETQRFANVLPVTIAHK
TSTDVTFQGYFIKKGTTVFPLMTSVLWDESEWETPRTFNPAHFLDKDGKFFKRDALMPFGAGRRACPGESLARME
LFLFFTSFLQRFRFTPPPGIKEDDLDLTPAVGLTLAPSPHELCAVSREGIQNE*
CYP2K26 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XVIII (-) strand 12862313-12864957
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
73% to Fugu 2K11 see EST DN708008.1
MGIVDQVLESSSSASLLGVLLVLLLVYLASSFSLGSPKDRKEPPGPTPLPLIGNLLQLDLKRPYNTLLKLSKKYG
SVFTVYMGPEKVVVLAGYKTVKEALVNRAEEFGDRQAMLIIREFNQGHGVIWSNGDSWKDMRRFALTNLRDFGMG
KRASEDKIIEECEHLIEVFKKHK (1)
GEPFDTTQPMNYAVSNIICSIVYGSRFEYDDPQFTSLVDRTNRTIQLV
GSPSIQLYNLFPWIGKWIANRNEVETLITANKKQNLQLFSRLKETLNPLMCRGFVDAFLVRKQNLEESKNTNSHF
NDDNLMQTVLNLFAAGTDTTATTLRWGLLFMVKNPKIQ (1 GC boundary)
DRVREELSEVVGSRQVQVEDRKKLPFTDAVIHETQRLANIVP
MAIPHKTTQDVTFQGHFIKKGTTVFPLLTSVLYDESEWEEPHSFHPAHFLDADGKFIKRDAFMPFSAGRRVCLGE
SLARMELFIFFSTLLQRFRFTAPPGVSVEDLDLTPRVGFTLNPSTHKLCAVPCV*
CYP2K27 Oryzias latipes (medaka)
chr8:11128109:11132739: (-) strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
66% to Fugu 2K10
MDLLMPLVSSPTTVIGAVFLLLVLYLASAGSTSRDLGKDPPGPRPLPLLGNLLQLDPRRPHKALCELSKSYG
PVFTVYFGIQKVVVLAGYKTVKEALVNNAEEFGDRDITPMFQDMNKGHGILFANGESWKELRRFALTTLRDFGMG
KRIAEEKILEECDYLIQGLEKHQGRKFDLTCPLNYATSNIISSIVYGSRFDYDDPRFRNLVSRANETIRINGHPL
THLYNMFPRWFRWIKNRKIILNNVEMTVKDVKDLVKHLKETLNPSVCRGFVDCFLIKKQKEEDSCVKESHFTEQN
LVFSVSNLFAAGTDTTATTLRWGLLLMAKYPHIQDKVHEELAKVLGGRQVRVDDRKNLPYADAVIHEIQRVANII
PMSIPHKTNRDVTFHGYLIQKGTTVIPLLASVLNDENEWESPHTFNPHHFLSKEGKFVKRDAFMPFSAGRRACLG
ESLAKMELFLFFTSLLQRFHFTPPPGVSEEELDLTPAMGFVLAPSSHELCAVSLQ*
CYP2K28 Oryzias latipes (medaka)
Chr8: 11120126:11125947: (-) strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
62% to Fugu 2K19
MIQYIFRFMPASVSLMWVIVGVLVLLFLYFQLSFFNWREPPGPRPLPLLGNLFQVDLKRLDQSLFDLSKKYGPVF
VVNFGPKKVVVLAGYRTVKQALVNQAKEFGNREVTPIFYDFNKEHGILFANGESWNEMRRFALSTLRDFGMGKRI
SEQNIIEECRWLIEELEKLQGKPFDNTHTISYAVSNVLSGLMFGKRFDYQDPLLQAIVDRDNEIIYLTGTVSILL
YNMFPWLGPWLKNWKTLMKNMEAAKTDMKKIIAELKDTLDPDTRRCFVDAFLTQKQNLKEVNGSHYHDDNLLYTV
MNLFAAGTDTTATTIEWCLLFMAKYPHIQERVQEELNWVVGSRQVRIEDRKNLPFTDAVIHESQRLANIAPMAIP
HTTSKDVTFQGYFIKKGTTVLPLLTSVLYDESEWESPRTFNPSHFLDKEGKFLKRGAFMPFSAGRRVCLGESLAR
MDIFLFFTSLLQHFSFTPPPGVSEDELDLTPVVGFTLSPQPQGLCAVRRQ*
CYP2K29 Oryzias latipes (medaka)
Chr24: 11283779:11289362: (+) strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
68% to Fugu 2K11
MQILDFFQSYSSVSLVGILAVLVLYFISQFIFNSEQHGQEPPGPRPLPIIGNLMQIDLKRPYKTLEEFSKTYGPV
FTVFFGGEKVVVLAGYKTVKNALVNHDEEFGERAIPPIIQELNKGLGVLWSNGDIWRDIRRFALTNLRDFGMGKK
ACEDKITEECQYLLEVFKKFKGNAFDTTKPLNYAVSNIICSMVYGSRFEYDDPKFTSMVDRTNRNIQLSGSPTLQ
AYNMVPWLFKWVASRREVHECAAANRKQNQSIFSHLKETLNPQMCRGFVDAFLVKGQTLEKSGVTNSAFNDENLL
MTVIHLFAAGTETTSTTLRWGLLLMAKYPKIQDQVQDELRRVIGDRMVQVSDRKNLPFTDAVIHEIQRLASIVPT
ALPHKTSKDVTFQGYFIKKGTTVFPLLTSVLHDANEWEKPHTFYPAHFLDKDGKFVKREAFIPFSAGRRICLGES
LARMELFMFFTTLLQNFCFTPPPGVSKEELSLTPCGGITVGPVPHKLCAVPCSE*
CYP2K30 Oryzias latipes (medaka)
Chr24: 11290118:11301397: (+) strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
63% to Fugu 2K11
MGVWDTLLPSLSPSSLLGAGVLLLLVFLFCPHRTSSQKHRKEPPGPTPIPILGNLHQLDLKRPDQTFMKFAKKYG
SVFTVYMGPKKTVVLTGYKTMKEALVNYAEEFGEREAPTVAKEAHLDCGVVWANGASWREMRRFALSTLRDFGMG
KRACEDKIIPECHSLLKEIRKFQGEAFDPTLIINSAVCNVICSMVYGTRFEYDDPDFRTILSRTMKGIQLLGSPG
VQLHNLFPRIGRLFLSASKQINQIFTANKNYHLKLLKETFTPHTCKSIADAFQLRQQEEDGFPNSHFHDANILVT
IMNLFTAGTETTAATLRWALLFMAKYPKIQDQVQEELSRVMEGRQVTVEDRQRLPFTDAVIHETQRKANIIPLSL
LHRTSQDVTFKGFFIEKGTTVIPVLTSVLYDENEWEKPNIFYPAHFLSKDGKFLKRDAFMPFSAGRRLCLGESLA
RMELFLFFSTLLQHFRIAPPLGVSEEELDLTPRPGGTLSPQPHKLCLVSLK*
2L Subfamily
CYP2L1 Panulirus argus (spiny lobster)
GenEMBL U44826 (1601bp)
James, M.O., Boyle, S.M., Trapido-Rosenthal, H., Carr, W.E.
and Shiverick K.T.
cDNA and protein sequence of a major form of P450, CYP2L,
in the hepatopancreas of the spiny lobster Panulirus argus.
Arch. Biochem. Biophys. 329, 31-38 (1996)
CYP2L2 spiny lobster
no accession number
Sean Boyle and Margaret O. James
submitted to nomenclature committee
2M Subfamily
CYP2M1 Onchorhynchus mykiss (rainbow trout)
GenEMBL U16657
Yang,Y.H., Wang,J.L. and Buhler,D.R.
cDNA cloning and characterization of a novel cytochrome P450 from rainbow
trout.
Abstracts of the VII International Congress of Toxicology,
Vol. 7, No. 1, 10-P-2 (1995)
Yang,Y.H., Wang,J.L., Miranda, C.L. and Buhler,D.R.
CYP2M1: cloning, sequencing, and expression of a new
cytochrome P450 from rainbow trout liver with fatty acid
(omega-6)-hydroxylation activity.
Arch. Biochem. Biophys. 352, 271-280 (1998)
Note: 42% identical to CYP2K1
2N Subfamily
CYP2N1 Fundulus heteroclitus (killifish)
John Stegeman
submitted to nomenclature committee
CYP2N2 Fundulus heteroclitus (killifish)
John Stegeman
submitted to nomenclature committee
CYP2N3 Stenotomus chrysops (scup)
No accession number
Agnes Knorr, Andrew McArthur John Stegeman
Submitted to nomenclature committee Nov. 3, 2000
73% to 2N1
CYP2N4 Chaetodon mertensii (butterfly fish)
No accession number
Bryan DeBusk
Submitted to nomenclature committee July 19, 2001
CYP2N5 Chaetodon punctatofasciatus (butterfly fish)
No accession number
Bryan DeBusk
Submitted to nomenclature committee July 19, 2001
CYP2N6 Chaetodon auriga (butterfly fish)
No accession number
Bryan DeBusk
Submitted to nomenclature committee July 19, 2001
CYP2N7 Chaetodon xanthurus (butterfly fish)
No accession number
Bryan DeBusk
Submitted to nomenclature committee July 19, 2001
CYP2N8 Chaetodon plebius (butterfly fish)
No accession number
Bryan DeBusk
Submitted to nomenclature committee July 19, 2001
CYP2N9 Fugu rubripes (pufferfish)
No accession number
Scaffold_3261a
9342 MWLWDLVLWLRLTGFLLPVLIVLLIIMYSLRQKDPPNFPPGPPALPLLGNIFNIEAKQPHLYLTK 9148 (0)
LADVYGSVFCIRLGRHKTVFVSGWKMVKEAIVTQADSFVDRPYSPMATRIYSGNS LKG95403.y1
AGLFFSNGHVWRKQRRFAMATLRSFGLANGSMELSICEESRHLQEAMESQK LKG95403.y1
8235 GEPFDPVPLLNNAVANIICQIVFGRRFDYTDHMFQRMLHHLTEMAYLEGSIWAL 8074 (0)
7991 LYDSFPALMKHLPGPHNGIFSSSSSLQGFIWREIQRHKSDLDPSNPRDYIDAFLIEEG 7818 (0)
7743 NGNNQLGFEERNLVLCCLDLFLAGSETTSKTLQWGLIYLIRKPHIQ 7606 (1)
EKVQVEIDRPIGRTRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNGPSNGCQGTRPWRGYFIPK (0)
GTSVMPNLTSVLFDKNEWETPDTFNPEHFLDAEGKFVRREAFLPFSA 7246 (1)
7162 GRRACLGEGLARMELLLFFVSLCQRFHFSTLDRVELSTEGITGATRTPYPFKIYAQVR* 6986
CYP2N10 Fugu rubripes (pufferfish)
No accession number
Scaffold_3261b
13883 MWLYSVLSWDFTSLLLFFFVLILFANYLKNRDPPNFPPGPFAFPIVGNFFTMDSKNLHLYFNK 13695 (0)
12557 LADVHGNVFSFRLGGDKMVCVSGHKMVKEAIVTQADNFVDRPYDPISARVYGGQT 12393 (1)
DGLFQSNGEVWKRQRRFALSTLRNFGLGKNILEQSICEEAQHLLEEMRSHG 12153 (1)
GKPFNPARLFNNTVSNIICQLVMGKRFEYSDHKFQMLLKYLSEVLVLEGSFWGQ 11913 (0)
11814 LYEAFPSVMKHLPGPHNKVFSHFNHLKDFMNEEIQNHKKDLDHNNPRDYIDAFIIEMEK 11638 (0)
NKDTNLGFTETNLAMCSLDLFIAGTETTATTLLWDLVYLINNPDIQ 11413 (1)
11290 GKVQAEIDQVIGQNRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNGPRMAAKDTTLGGYFIPK 11102 (0)
11018 GTSLMPILTSVLFDKNEWETPDKFNPGHFLDAEGKFKKREALLPFSA (1)
GKRVCLGEGLAKMELFLFFVSLFQNFTFFVPGGAELNTEGITGTTRVPHPFEILARPR* 10619
CYP2N11 Fugu rubripes (pufferfish)
No accession number
Scaffold_3261c
MWPLQLLLDFDIRALLLFISVLLLIGDYFRYKNPPNFPPGPMSLPFVGSFFSVDSKHPHNYFIQ (0)
18495 MAELYGKLFSIRLGSGKIVFACGYKMVKEAIVTQADNFVDRPFNAFGDRIYMGQR 18331 (1)
18251 DGLFQNNGEVWKRQQHFALSTLRNFGLGKNILEQSICEEAQHLLEEMRSHG (1)
GKPFDPASLFTRAVSNIICQLVMGKRFEYSDHKFQMLLKYLSELLVLEGSFWGQ 17859 (0)
LYQAFPSVMKHLPGPHNKVFSHYNHLKDFMNEEIQNHKKNLNHNNPRDYIDAFIIEMEK (0)
17498 NKDTNLGFTETNLVLCSLDLFLAGTQTTATTLLWALVYLINNPDIQ 17364 (1)
16988 EKVQAEIDQVIGQTRQPTMADRPNLPYTDAVIHEIQRMGNIVPLNASRMAAKDTTLGGYFIPK 16800 (0)
GTSLLPILTSVLFDKNEWETPDKFNPGHFLDAEGKFKKREAFLPFSA (1)
16492 GKRVCLGEGLVKMELFLFFVSLFQKFSYSVSGGAELSTEGITGITRVPHPFEIHTRPRSF* 16310
CYP2N12X Fugu rubripes (pufferfish)
No accession number
Scaffold_3261d
Renamed CYP2AD1
22960 XCLNIHTGIALSNGYMWKKQRKFAHTHLRYFGEGQKLLENHIQMESKFMCEAFKDEQ 22811 (1? Bad boundary)
22727 GKPFDPQYTITNAVGNIISALVFGHRFEYSDASFRRILELDNEAVVLAGSARTQ 22566 (0)
22482 LYDSFPSLMKHLPGPHQTVHANYGKITDFLKKEVDKHMEEWNPEDPRDYVDTYLSEMEK 22306 (0)
21959 MNQDPQGGFNVETLLICILDLIEAGTESAATTLRWGLVFILNYPDVQ 21819 (1)
21739 EKVQEEIDRVIGQSRQPAMADRPNMPYTDAVIHEIQRFANVVPAGFPKMATKDTTVGGYFIPK 21551 (0)
21462 GLAITTMLSSVLFDKNEWETPDVFNPNHFLDSEGRFRKRDAFIPFSA 21322 (1)
21218 GKRVCIGENLAKMELFLFFTSILQHFNLSPVPGQMPSLEGILGFTYSPQPFRMIVAPR* 21042
CYP2N13 Danio rerio (zebrafish)
CYP2N14 Micropterus salmoides (largemouth bass)
No accession number
Alex J. McNally
submitted to nomenclature committee May, 31, 2005
74% to 2N10
CYP2N15 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr VIII (+) strand 19111307-19114904
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
69% to 2N11
see ESTs CD506195.1, CD504080.1, CD507761.1
the genome assembly is missing the lower case region
MWLFHFLLGFDLKGLFLFMVVFFIIADIFKNRNPANYPPGPLSLPIVGNffsverkhphiyftk
LADIYGNVFSVRL
GRNKTVFVSGYKMVKEAIVTQADNFVDRPDNAMADRVYSGDSGGLFMSNGETWKRQRRFALSTLRSFGLGKSTME
QSICEEIRHLQEEIEKEKGEPFNPASLFNNAVSNIICQLVMGRRFDYCDHNFQSMLTYLCEILRLQGSVWGLLYD
SFPRVMKHLPGSHNKIFSHYDSLLDFMNKEVESHKKDLDHSDPGDYIDAFIIEMEKHNESDLGFTEANLALCSLD
LFLAGSETTSTTLLWALVYLMKYPDIQDKVQVEIDGVIGRSRQPSMADRPNLPYTEAVLHEIQRMGNIVPLNGAR
MATKHTTLGGYLIPKGTTVMPSLTSVLFDKTEWETPHTFNPGHFLGAEGKFVRREAFLPFSAGKRVCPGEGLAKM
ELFLFLVGLLQKFSFSVPDGVELSTEGITGVTRVPHPFKVYAKAR*
CYP2N16 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr VIII (+) strand 19116076-19119924
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
77% to 2N9, 62% to Fugu 2N10
MSLCGFLLRFGPPEFLLLFFAFLLLVCFWAKKDPPNFPPGPPSLPFLGNIFNIESKQPHIYLTKLADVYGNVFCI
RLGRHRTVFVSGWKMVKEAIVTQADHFVDRPYSPMVTRIYSGNSGLFFSNGKVWRRQRRFAMSTLRTFGLANSSM
EQSICEESRHLQEALEKEKGEPFDPVPLINNAVANIICQIVFGRRFDYTDHNFQSMLRNLTDMAYLEGSIWALLY
DAFPAVMKHVPGPHNGIFRSSRSLEASIRAEIERHKLDLDPTNPRDYIDLFLIEEKHSKNRDLGFDEGNLVLCCL
DLFLAGSETTSKTLQWGLVYLIKSPHIQVQAEIDGVIGPTRHPTMADRPNLPFTDAVIHEIQRVGNVVPLNGLRM
AAKDTTLGGYFIPKGTSVMANLTSVLFDPAEWEKPDSFHPAHFLDAGGRFVRREAFLPFSAGKRACLGEGLARAE
LFLFFVTLLQKYHFTTLEGVELRGDGVIGATRTPHPFKVYAEAR*
CYP2N17 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XVI (-) strand 2228495-2232907
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
51% to Fugu 2N9, 71% to 2N12, see ESTs DT966028.1, DW631570.1
CYP2N18 Oryzias latipes (medaka)
Chr4: 28082010:28087962: (-)strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
67% to Fugu 2N11
MWLDSFLLSFDLKALVLFIFLFLLIADWIKHRKPANFPPGPLGLPFVGNFLTIDGKHPHIYFSKMAESYGNVFSV
RLGSQATVFVSGYKMVKEALVTQAENFVDRPFSEIGGRFYEGNSNGLFFSNGEKWKKQRRFALSTLRTFGLGKNT
MEQSICEEIRHLQQQIENEKGGPFSPAGLFNNAVSNIICQLVMGKRFDYDDNNFQVMMKYISEAVQLEGSIWGIL
YESFPGLMKHLPGSHNKIFRNYKIVQDFLAQEIKIHKQDLDPNNPRDYIDSFIIEMEKHQNSDLGFNDANLAFCS
LDLFVAGTETTSTTLMWALIYLIKHPDVQVKVQQEIDRVIGQNRLPSMADRPNLPYTDAVVHEIQRIGNIVPLNG
LRVAAKDTTLGGYFIPKGTALMPMLTSVLFDKTEWETPDTFNPEHFLDADGKFVKKEAFLPFSAGKRVCLGEGLA
RMELFLFLVGLLQKFSFSVPEGVELSTEGITGTTRVPHPYKVYAKVR*
CYP2N19 Oryzias latipes (medaka)
Chr4: 28070384:28074070: (-) strand
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
74% to Fugu 2N9
MWLCVWCQWCGLTGTLFFIFAVFFVLCLVKQKDPPHFPPGPPALPVLGNIFSIDSKQPHIYLTKLADVYGNVFCI
RLGRHKTVFVTGWKTVKEALVTQADNFVDRPYSPMVTRIYGGNSAGLFFSNGSVWKRQRRFAMTMLRTFGAAKSS
TEQSICEESRHLLEAMEMEGGEPFDPVPLLNKAVSNIICQIVFGRRFDYSDTDFQAMLTNLTDMAYLEGSVWALL
YDAFPALMKYLPGPHNSIFSSSKSLETTIRREINRHKQDLDPSNPRDYIDKFLMEERHNRKIHSGFEEENLVLCC
LDLFLAGSETTSKTLQWGLIYLITNPHIQDKVQAEMDRVVGHSRQPTTADRTNMPYTDAVIHEIQRMGNIVPLNG
LRMAAKDTTLGGYIIPKGTAVMPNLTSVLFDKTEWETPDNFNPEHFLDADGKLLRKEAFLPFSAGRRACLGEGLA
RMELFLFFVTLFQRFHFSAAAGVELRTEGIIGATRTPHPFQIIAKPR*
2P Subfamily
CYP2P1 Fundulus heteroclitus (killifish)
John Stegeman
submitted to nomenclature committee
CYP2P2 Fundulus heteroclitus (killifish)
GenEMBL AF117342
John Stegeman
submitted to nomenclature committee
CYP2P3 Fundulus heteroclitus (killifish)
GenEMBL AF117343
John Stegeman
submitted to nomenclature committee
CYP2P4 Fugu rubripes (pufferfish)
No accession number
Scaffold_3261e
MEAILSTLGLEWMDGRTILIFLLVFVLLADYIKNRVPSNFPPGPWPLPLIGDLHRINPSRLHLQFAE (0)
24760 FAGKYGNIFSLRLFGGRVVVLNGYKTVREALVEKGENFVDRPLIPLFEAFAGNR 24924 (1)
24994 GLVISNGNPWKHQRRFALHTLRNFGIGKKSLEPSIQQECHYLAEAFAQHKG 25156
gap missing exon 4
26236 VYNTFPWLLKWLPGTHQTIFSEIKTVINFVDLKIQEHKRNFDPSSLRDYIDCFLAEMGE 26412 (0)
26493 KEDVESGFDMKNLSICTMDLFGAGTETTTTTLQWGLLYMIYYPHIQ 26630 (1)
seq runs off end of contig missing exons 7,8 and 9
CYP2P fragment Fugu rubripes (pufferfish)
No accession number
probably exon 7 of 2P4
Fc:c161F04y1 LPC.61739.y1 Fc:c161E03y1 LPC.61451.y1 60% to 2J9
71% to 2P1
KVYAEISAVIGSSREPSITDRDNMPYTNAVIHEMQRMANIIPLNVVHMASSDTTIxxxxxxx
CYP2P fragment Fugu rubripes (pufferfish)
No accession number
Scaffold_2841 probably exons 8 and 9 of 2P4
80% to LPC61680 66% to 2D9 Length = 29344
LPC61680.x1 LPC22842.y1 LPC61776.x1 LPC61672.x1 Fc:c161P11x1 Fc:c161P09x1
66% to 2D9 LPC61488.x1 64% to 2d9 Fc:c161O11x1 93% to LPC61680
probably same gene 67% to CYP2K, upstream sequence runs off scaffold
62% to 2Z2 over 106 aa 59% to 2K10 over 108 aa 60% to 2N12 over 100 aa
80% to 2P2
179 GTIIMPTLNSVLHDESMWETPHSFNPQHFLDQDGKFRKREAFLPFSA 319
442 GKRVCLGEQLARMELFLFFTSLLQRFSFSMADGEQPSLDFQLGGARFPKPYRLRAILR* 618
CYP2P5P Fugu rubripes (pufferfish)
No accession number
pseudogene fragment Fc:c060E24y1 LPC.22843.y1
56% TO 2W1 PKG TO HEME 70% to scaf 2841 exon 8
GTIVVPTLNSVLPDESVWETPHSLDPPLFLDL*RXFRVREAFLPFFA
CYP2P6 Danio rerio (zebrafish)
ctg24224.g NEW 77% TO 2p9
1209157 MDLLHIYEWIDIKAVLFFACVFLLLSNYIQNKTPKNFPPGPWPLPIIGNLYHIDFNKIHLEVEK 1209348
1209657 LSEKYGSVVSVHLFGQRTVILNGYKQVKEVYIQQGDNVADRPELPMIHDIAGDN 1209818
1209977 GLVAPSGYKWKQQRRFALSTLRNFGLGKKSLEPSINLECHYLNEAISNEN 1210126
1210235 GRPFDPHLLLNNAISNVICVLVFGNRFDYSDHHFQTLLNNINEAMYLDGTIWAQ 1210396
1210482 LYNSHPRIMRLLPGPHKKNITLWNKVIDFARERVKEHRVDYDPSNPRDYVDCFLAEMEK 1210658
1210736 LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLSWSLLYMIKYPEIQ 1210876
1212110 AKVQEEIDRVIGSSRQPSVSDRDNMPYTNAVIHEIQRFGNIAALNLPRAAVKDIQVGKYLIPK 1212298
1212390 GTIVIGNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS 1212527
1213310 GKRVCLGEQLARMELFLFFTSLLQHFTFSSPAGVEPSFNYKLGTTRAPKPFKLCAVSR 1213483
CYP2P7 Danio rerio (zebrafish)
ctg24224.h 81% to 2p9, 62% to 2P3 (Fundulus)
1214731 MDVLQFYKWLDIKTVLVFLVVFLFLSDYIRNKSPKNFPPGPWSLPFIGHIHHIEHKKVHLQFLK 1214922
1216466 FAEKYGKIFSIRLFGPRIVVLDGYKLVKEVYLQQGDNLADRPILPMFYDITEDK 1216627
1217670 GLIGSNGYKWKHQRRFALSTFRTFGLGKKSLEPSILLECSCLNDAFSNEQ 1217819
1217891 XPFDPRLLLNNAVSNVICALVFSNRFDYSDHHFQTLLKHINEVLYLEGTVWAQ 1218046
1218134 LYNFFPWLMRRLPGPHQKIFVLLNKVIDFVREKVNEHRVDYDPSNPRDYIDCFLAEMEK 1218310
1218399 LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYIIKYPEIQ 1218539
1218632 AKVQQEIDAVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIVPLNVFRITVEDTQIGEYSIPK 1218820
1218907 GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS 1219044
1219144 GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGGTHSPQPYKLCAVPR 1219317
CYP2P8 Danio rerio (zebrafish)
ctg24224.i 90% TO 2p9
1221362 MDLWYLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK 1221553
1221722 FAERYGNIFSFRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK 1228152
1221974 GLILSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINVECGFLNEAISNEQ 1222123
1222203 GRPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKNISEAVYLEGSICNQ 1222364
1224317 LYNMFPWLMERLPGPHKTIITLWRKVTDFVREKVNEHRVDYDPSNPRDYIDCFLTEMEK 1224493
1224582 LKDDTAAGFDVENLCICSLDLFVAGTETTSTTLYWGLLYMIKYPEIQ 1224722
1224812 AKVQEEIDAVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIAPINLARSTSEDTQIGNYSIPK 1225000
1225184 GTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS 1225321
1225421 GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKMGGTHCPKPFKLCAVPR 1225594
CYP2P8-de7,8 Danio rerio (zebrafish)
ctg24224.j EXONS 7,8 pseudogene
1226868 PSVSDRDNMPYTNSVIHEIQSIGNIGPLNVFGITVK 1226975
1227088 GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS 1227225
CYP2P9 Danio rerio (zebrafish)
ctg24224.k 98% (7 AA DIFFS) TO 2p9
1227637 MDLWYLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK 1227831
1227991 FAERYGNIFSLRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK 1228131
1228249 GIVLSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINLECGFLNEAISNEQ 1228398
1228473 GQPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKHINEAIYLEGGICAQ 1228634
1228798 LYNMFPWLMQRLPGSHKKVITLWKKVIDFIRQKVNEHKVDHDPLNPRDYIDCFLAEMEK 1228974
1229073 LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPVIQ 1229210
1229290 AKVQEEIDRVVGGSRHPSVSDRDNMPYTNAVIHEIQRMGNIIPINVTRTTSEDIRIGKYSVPK 1229475
1229629 GTMVTSNLTSVLFDESEWETPHSFNPGHFLNAEGKFRRRDAFLPFSL 1229769
1229866 GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGATHCPQPYKLCAVPR 1230039
CYP2P9 Danio rerio (zebrafish)
GenEMBL BC056816, NM_200620 61% to CYP2P3
zfishK-a583c07.p1c zfishC-a1218e09.p1ca
MDLWDLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK
FAERYGNIFSLRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK
GIVLSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINLECGFLNEAISNEQ
GQPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKHINEAIYLEGGICAQ
LYNMFPWLMQRLPGSHKKVITLWKKVIDFIRQKVNEHRVDHDPLNPRDYIDCFLAEMDK
LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPGIQ
AKVQEEIDRVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINVTRTTSEDIRIGKYSVPK
GTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL
GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGATHCPQPYQLCAVPR
CYP2P10 Danio rerio (zebrafish)
GenEMBL BC049521, NM_201511 84% to CYP2p9 zfishG-a2632g08.q1c
MDMFYFYEWVDIKSILIFLCVFLLLSDYIKNKAPKNFPPGPWSL
PFIGDLHHIDPNKIHLQFTEFAEKYGKIFSFRLFGSRIVVLNGYNLVKEVYTQQGDNL
ADRPTLPITSAIIGDNRGLVASSGYKWKHQRRFALTTLRNFGLGKKNLELSINFECGF
LNEAISNEQGRPFNPRLLLNNAVSNVICVLVFGNRFEYSDHHFQNLLNKINESVYLEG
SIFVHLYNMFPWLMQLLPGPHKKLITLWQRVTDFVREKVNEHRVDYDPSSLRDYIDCF
LAEMEKHKDDTAAGFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQQ
EIDAVVGSSRQPSGSDRDNMPYTNAVIHEIQRMGNIIPLNVVRTTSEDTRIEKYSIPK
GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSLGKRVCLGEQLA
RMELFLFFSSVLQRFTFSPPAGVEPSLDFKMGFTRCPKPYKLCAVPR
CYP2P10 Danio rerio (zebrafish)
ctg24224.l 3 AA DIFFS TO 2P10
1232262 MDMFYFYEWVDIKSILIFLCVFLLLSDYIKNKAPKNFPPGPWSLPFIGDLHHIDPNKIHLQFTE 1232411
1233540 FAEKYGKIFSFRLFGSRIVVLNGYNLVKEVYTQQGDNLADRPTLPITSAIIGDNR 1233677
1233779 GLVASSGYKWKHQRRFALTTLRNFGLGKKNLELSINFECGFLNEAISNEQ 1233928
1234024 GRPFNPRLLLNNAVSNVICVLVFGNRFEYSDHHFQNLLNKINESVYLEGSIFVH 1234173
1237098 LYNMFPWLMQLLPGPHKKLITLWQRVTDFVREKVNEHRADYDQSSLRDYIDCFLAEMEK 1237274
1237383 HKDDTAAGFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQ 1237523
1237610 AKVQQEIDAVVGSSRQPSGSDRDNMPYTNAVIHEIQRMGNIIPLNVVRTTSEDTRIEKYSIPK 1237798
1239047 GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL 1239184
1239282 GKRVCLGEQLARMELFLFFTSVLQRFTFSPPAGVEPSLDFKMGFTRCPKPYKLCAVPR 1239455
CYP2P10-de9 Danio rerio (zebrafish)
ctg24224.m 3 AA DIFFS TO 2P10
1242741 MELFLFFSSLLYF 1242779
1242772 FTFSLPADVKPSLGYKMGAHTVP 1242840
CYP2P-se1 Danio rerio (zebrafish)
ctg24224.n solo exon (pseudogene)
1243476 MDMLHFYEWIDIKSILIFVCVFLLLSDFIKNKTPKNFPPGPWSLPIIGDIHHIDPSKLHLQLSE 1243667
CYP2P fragment Atlantic salmon
GenMEBL BI468047 EST00457
77% to CYP2P10
1 DPSSPRDFIDCFLNEIEKCEDDTRAGFNLENLSFCTLDLFVAGTETTSTTLYWGLLFMIN 180
181 YPEIQAKVQAEIDAVVRSSRQPSMEDRDSMPYTDAVIHETQRMGNIIPLNVSRMATKDTE 360
361 VGGYTIPKNTIVLGTLQSILFDESEWETPHTFNPGHFLDQEGKFRKRDAFLPFSLGKRVC 540
541 PXEQLAKMELFLFFTSLLQRFTFFSPPGVEPSL 639
CYP2P11 Micropterus salmoides (largemouth bass)
No accession number
David Barber
Submitted to nomenclature committee 5/21/04
73% to CYP2P3
CYP2P12 Oryzias latipes (medaka)
chr4 28112615:28120754 (+)
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
61% to Zebrafish 2P10, 69% to CYP2P3
MEGITSVLGLEWVDTWTILIFLFVFLLLSDFLANRRPKNFPPGPHSLPFIGDLHRIQPARLHVQFTEFAEKYGNV
FSLHLLGERTVILNGYKQVKEALVQQGDDFVDRPTIPLFVDTIDNKGIVMSNGNSWKQQRRFALHTLRNFGLGKK
TMETYIQNECHYITQTFADKQGKPFDAQFLINNAVSNIICCLVFGERFEYSDQEYQKILRNLNDLLILEGSVSAM
LYNMFPWLMKRLPGPHQKIFSLTRKIIDFVKIKINEHKGNFDPSAPEDYIDSFLIEMEKVNKDSGFDIDNMCICT
MDLFLAGTETTTTTLYWGLLYMIYYPDIQGKVHAEIDAVIGSSRQPSMADKESMPYTDAVIHEIQRMGDIVPQGV
FRQANRDTTLDKYTIPKGTIIVPALHSVLHDESMWDNPHSFDPKNFLDKDGKFCKREAFNPFGAGKRVCLGEQLA
RMELFLFFTSLFQRFSFSAPTGEQLSLESRMGATRCPKPFRVIAAPR*
CYP2P13 Oryzias latipes (medaka)
chr4 28123180:28130065 (+)
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
63% to Zebrafish 2P10, 75% TO CYP2P3
MEAITAVLGFEWIDSRSLLIFLFVFLLLSDYLANRRPKNFPPGPHSLPFIGDLHRINPSRLHLQLTEFAEKYGNV
FSLHLFGERAVILNGHKHVKEALVQRGDDFVDRPSIPLFEQFYSNKGIVVSNGYPWKQQRRFALHTLRNFGLGKK
TMEKYMQEECRYLTEAFGEYKVKPFNAQALINNAVSNIICCLVFGERYEYSDKQYQQILQDINEIMILQGGFAAQ
LFNSFPWLMKKLPGPHQKILTLLAKLIDFAKVKISEHKENLDPSSPKDYIDSFLIEMAQNENQESSFDISNLCMC
TLDLFIAGTETTTTTLHWGLLYMIYYADIQEKVQAEIDAVIGSSRQPSMADKENMPYTDAVIHEIQRMGNILPLG
VLRMASKDTTLDKYTIPKGTMIIPTLNSVLHDESMWETPHSFNPKHFLDKDGKFRKREAFNPFGAGKRVCLGEQL
ARMELFLFFTSLLQRFSFSAPAGEQPSLENRMGATRCPKPYRLCAVPR*
2Q Subfamily
CYP2Q1 Xenopus laevis (african clawed frog)
GenEMBL D50560 (2237bp)
Ohi, H., Sugata, E., Fujita, Y., Saito, H., Saguchi, K., Murayama, N.
and Higuchi, S.
Cloning and expression analysis of a cDNA coding for a
dexamethasone-inducible cytochrome P450 in Xenopus laevis
Biochem. Mol. Biol. Internatl., 45, 689-697 (1998).
Saito, H., Ohi, H., Sugata, E., Murayama, N., Fujita,Y. and Higuchi,S.
Purification and characterization of a cytochrome P450 from liver
microsomes of Xenopus laevis
Arch. Biochem. Biophys., 345, 56-64 (1997)
CYP2Q2 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2Q3 Xenopus tropicalis (frog)
See Xenopus page for seq
2R Subfamily
CYP2R1 human
AC018795.4 also AC025730 AC025748
Mikael Oscarson
submitted to nomencalture committee 9/4/98
missing N-terminal (approximately 80 amino acids)
Unigene entry Hs.16846
ESTs AA058765 zk65e06.r1, AA099882 zl90c08.r1, AA115448 zl04h11.r1
AI280096 qh85e09.x1, AA732048 nz87c04.s1, AA449325 zx06e11.s1,
AI221745 qg93e12.x1, AA088847 zl90c08.s1, AA235247 zs37b03.s1,
AA115449 zl04h11.s1, AI431661 tg74h07.x1, AI376519 te59a09.x1,
T83549 yd44f12.r1, T91507 ye20c08.s1, R11612 yf47e10.r1,
T91536 ye20c08.r1, AA449583 zx06e11.r1, T83719 yd65h05.r1
AA663042
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIY
SLAASSELPHVYMRKQSQVYGE
IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR
YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS
NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR
NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI
IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV
LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS
SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT
LQPQPYLICAERR
CYP2R1 Macaca mulatta (rhesus monkey)
partial
IFSLDLGGISTVVLNGYDVVKECLVHQSGIFADRPCLPLFMKMTKMGGLLNSRYGQGWVE
HRRLAVNSFRYFGYGQKSFESKILEETKFFTDAIETYKGRPFDFKQLITSAVSNITNLII
FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNASVVYD
FLSRLIEKASVNRKPQLPQHFVDAYFDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT
TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKFKMPYTEAVLHEVLRFCNIV
PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK
EALVPFSLGRRHCLGEQLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYL
ICAERR
CYP2R1 Bos taurus (cow)
See cattle page for details
MWEPHSAEAFVAALGGVFFLLLFALGVRQLLKQRRPSGFPPGPSGLPFIGNIYSLAASAELPHVYMKKQSQVYGE (0)
IFSLDLGGISAVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG (1)
GLLNSRYGRGWVDHRKLAVNSFRCFGYGQKSFESKILEETKFFIDAVETYNGSPFDLKQLV
TNAVSNITNLVIFGERFTYEDTDFQHMIELFSENVELAASATVFLYNAFPWIGILPFGKH
QQLFRNAAVVYDFLSRLIEKASINRKPQLPQHFVDAYLDEMERSKNDPSSTFSKENLIFS
VGELIIAGTETTTNVLRWAVLFMALYPNIQ (1)
GQVQKEIDLIIGPSGKPSWDEKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSI
PKGTTVITNLYSVHFDEKYWRDPEIFYPERFLDSSGHFAKKEALIPFSL (1)
GRRHCLGEQLARMEMFLFFTALLQRFHLHFPHELVPNLKPRLGMTLQPQPYLICAERR*
CYP2R1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
95% to human 2R1
partial seq.
CYP2R1 Sus scrofa (miniature pig)
BW980853.1, BG732954.1, BI359965.1
95% to human 2R1, lower case = cow seq
MWEPPGAEVFPAALGGVL
2 FLLLFALGVRQLLKQRRPSGFPPGPSGLPFIGNIYSLAASAELPHIYMKKQSQVYGEIFS 181
182 LDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRR 361
362 LAVNSFRSFGYGQKSFESKILEETKFFMDAIETYSSRPFDFKQLITNAVSNITNLIIFGE 541
542 RFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLS 721
722 RLIEKASINRKPQSPQHFVDAYLDEMDQGEKDPSSTFSKENLIFSVGELIIAGTETTTNV 901
902 LRWAILFMALYPNIQGR 952
vqkeidliigpsgkpswdekckmpyteavlhevlrfcnivplgifhatsedavvrgysi
pkgttvitnlysvhfdekywrdpeifyperfldssghfakkealipfsl (1)
GRRHCLGEQLARMEMFLFFTALLQRFHLHFPHelvpnlkprlgmtlqpqpylicaerr*
CYP2R1 Canis familiaris (dog)
NW_876313.1:37769697-37744500
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
93% to human CYP2R1
MRGPPGAEACAAGLGAALLLLLFVLGVRQLLKQRRPAGFPPGPSGLPFIGNIYSLAASGELAHVYMRKQSRVYGE
IFSLDLGGISAVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRKLAVNSFRCFGYG
QKSFESKILEETNFFIDAIETYKGRPFDLKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASAS
VFLYNAFPWIGIIPFGKHQQLFRNAAVVYDFLSRLIEKASINRKPQSPQHFVDAYLNEMDQGKNDPSCTFSKENL
IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPTGKPSWDDKCKMPYTEAVLHEVLRFCNIV
PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRNPEIFYPERFLDSSGYFAKKEALVPFSLGKRHCLG
EQLARMEMFLFFTALLQRLHFPHGLVPDLKPRLGMTLQPQPYLICAERR*
CYP2r1 mouse
GenEMBL XM_146091.1
1 MLELPGARACAGALAGALLLLLFVLVVRQLLRQRRPAGFPPGPPRLPFVGNICSLALSAD 180
181 LPHVYMRKQSRVYGE
IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLL 540
541 NSRYGRGWIDHRRLAVNSFHYFGSGQKSFESKILEETWSLIDAIETYKGGPFDLKQLITN 720
721 AVSNITNLILFGERFTYEDTDFQHMIELFSENVELAASAPVFLYNAFPWIGILPFGKHQR 900
901 LFRNADVVYDFLSRLIEKAAVNRKPHLPHHFVDAYLDEMDQGQNDPLSTFSKENLIFSVG 1080
1081ELIIAGTETTTNVLRWAILFMALYPNIQGQVHKEIDLIVGHNRRPSWEYKCKMPYTEAVL 1260
1261HEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWKDPDMFYPERF 1440
1441LDSNGYFTKKEALIPFSLGRRHCLGEQLARMEMFLFFTSLLQQFHLHFPHELVPNLKPRL 1620
1621GMTLQPQPYLICAERR 1668
CYP2R1 chicken
XM_420996 Gnomon prediction seems too long
80% to human 2R1
MGPAAGDAEPEAAAGGGPWLL
LALPPLLLLFALVVRQLLKQRRPPGFPPGPAGLPLIGNIHSLGAEQPHVYMRRQSQIH
GQIFSLDLGGISAIVLNGYDAVKECLVHQSEIFADRPSFPLFKKLTNMGGLLNSKYGR
GWTEHRKLAVNTFRTFGYGQRSFEHKISEESVFFLDAIDTYKGRPFDLKHLITNAVSN
ITNLIIFGERFTYEDTEFQHMIEIFSENIELAASASVFLYNAFPWIGILPFGKHQQLF
KNAAEVYDFLHKLIERVSENRKSQSPRHFIDAYLDEMDCNKNDPESTYSRENLIFSVG
ELIIAGTETTTNVLRWAVLFMALYPNIQGHVQKEIDLVIGPNKMPALEEKCKMPYTEA
VLHEVLRFCNIVPLGIFHATSKDTVVRGYSIPEGTTVITNLYSVHFDEKYWNNPEVFF
PERFLDSNGQFVKKDAFIPFSLGRRHCLGEQLARMELFLFFTSLLQRFHLRFPHGGIP
DLKPRLGMTLQPQPYLICAERR
CYP2R1 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2R1 Danio rerio (zebrafish)
CYP2R1 Fugu rubripes (pufferfish)
No accession number
Scaffold_7138
69% to human 2R1
MVPAQSPPLVPPSRDQALLGLACLTVAFLAVLLVRQLVK
QRRPPGFPPGPSPIPIIGNIMSLATEPHVFLKKQSEVHGQ (0)
IFSIDLGGILTVVLNGYDCIRECLYNQSEVFADRPSLPLFKKMTKMG 12808
12701 GLLNCKYSKGWIEHRKLACNSFRYFGSGQRLFERKISEECMFLVDAIDQHKGKAFNPKHL 12522
12521 VTNAVSNITNLIIFGQRFTYDDHNFQHMIELFSENVELAVSGWALLYNAFPWIEYLPFGK 12342
12341 HQKLFFNAAEVYDFLLRVTKEFSQGRVPHMPRHYVDAYLDELERNAGDPNSSFSYENLIY 12162
12161 SVGELIIAGTETTTNTLRWAMLYMALYPNIQG
RVHREIDSVLANGRMPTLEDKQKMPYVEAVLHEVLRFCNIVPLGIFRATSQDA 11802
11801 NVNGYTIPKGTMVITNLYSVHFDEKYWSDPGVFSPQRFLDANGNFVRREAFLPFSLG 11631
11535 GRRQCLGEQLARMEMFLFFTTLLQRFHLQFPVGTIPTIAPKLGMTLQPKPYSICAVRR 11362
HQKSLISVTTPCHK* 11317
CYP2R1 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr II (+) strand 9716095-9718823
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
88% to Fugu 2R1
MVSIKAQSLVPVSCAQALLGVVCLAVALLAFLLVRQLVKQRRPPGFPPGPSPIPVIGNIFSLATEPHVFLKRQSE
VHGQIFSLDLGGILTVVLTGYDCVRECLYNQGEVFADRPSLPLFKKMTKMGGLLNCKYGKGWIEHRKLACNSFRY
FGSGQKQFERKISEECMFFVDAIDEHKGKPFNPKHLVTNAVSNITNLIIFGQRFTYDDRNFQHMIEIFSENVELA
VSGWALLYNAFPWIEYVPFGKHQKLFRNAAEVYDFLQEVIQSFSQGRVPHSPRHYVDAYLDDLERSAGAPDSSFS
YENLIYSVGELIIAGTETTTNTLRWAMLYMALYPNIQERVHREIDSVLANERAPTLEDKQKMPYVEAVLHEVLRF
CNIVPLGIFRATSQEAKVNGYTIPKGTMVITNLYSVHCDEKYWNDPGAFSPQRFLDSNGNFVRREAFLPFSLGRR
CCLGEQLARMEMFLFFTTLLQRFHLQFPAGSIPTVTPKLGMTLQPKPYSICAVRRQQKSPCFGDTPYPN*
CYP2R1 Oryzias latipes (medaka)
chr3 17795604:17802282
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
87% to Fugu 2R1
MVSLTAASVVPVSRAMALLSVGCLAAALMAYLLVRQLVKQRRPPGFPPGPSPIPIIGNIFSLATEPHVFLKRQSE
VHGQIFSLDLGGIMTVVLNGYDCVKECLYHQSEVFADRPSLPLFKKMTKMGGLLNSKYGKGWNDHRKLACNSFRY
FGSGLRLFERKISEECMFFVDAIDEHKGKPFNPKHLVTNAVSNITNLIIFGQRFTYDDRDFQHMIELFSENVELA
VSGWALLYNAFPWIEYMPFGKHQKLFRNAMEVYDFLLEVIKRFSHGRVPHVPRHYVDAYLDELEQNSGDPSSSFS
YENLIYSVGELIIAGTETTTNTLRWAMLYMALYPNIQERVHREIDSVLTNGRAPTLEDKHKMPFVEAVLHEILRF
CNIVPLGIFRATSQEAKVNGYTIPKGTMVITNLYSVHFDEKYWNEPGVFSPQRFLDSSGNFVRREAFLPFSLGKR
HCLGEQLARMEMFLFFTTLLQRFHLQFPPGTVPTVTPKLGMTLQPKHYSICAIRRQQKVPNS*
CYP2R2P Fugu rubripes (pufferfish)
No accession number
Fc:c104I03x1 LPC.39565.x1 77% to fugu 2R1 MAY BE PSEUDOGENE OF scaf 7138 exon 8
201 DSVLANGRMPTLEDKQKMPYVEAVLHEVLRFCNIVPLGIFRATS*DANVNGYTIPKGTM 220
221 VITNLYSWHFYEKNWSKTGAFSHPKCLWDAHGHFCEWLMASMPGSFG 518
CYP2R3P Fugu rubripes (pufferfish)
No accession number
Fc:c068L08y2 LPC.26046.y2 67% to fugu 2R1 exon 8 possible pseudogene fragment
LYYTKIXTVLARVEIPTLEDKQKMPYLEAVLPEVLRFCDIVPLGLFRATSAGADVNGFTIPGGAVLIAILCSGRF
2S Subfamily
CYP2S1 human
GenEMBL AF335278 AC011510
ESTs T84852, AA315278, AA300981 and AA301039
AA316621, AA496320, AA422150
Rylander, T., Neve, E.P.A., Ingelman-Sundberg, M. and Oscarson, M
Identification and tissue distribution of the novel human cytochrome
P450 2S1 (CYP2S1)
Biocem. Biophys. Res. Commun. 281, 529-535 2001
There is no UNIGENE entry for any of these ESTs
52% identical to CYP2B subfamily members and 50% with CYP2A
members 50% with CYP2G1.
AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13
MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMR
LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH
GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE
GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQ
TYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ
EEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ
KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ
GTEVFPLLGSILHEPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSL
GKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR
CYP2S1 Macaca mulatta (rhesus monkey)
AC011510
exons 2,3 from CO649282.1, gene fragmented on multiple scaffolds
MEATGTWALLLALALLLLLTLALSGTRARGQLPPGPTPLPLLGNLLQLRPGALYSGLMR (0)
LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH (1)
GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE (1)
GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAMVRAAGGTLLGVSSRGGQ (0)
TYEMCSWFLWPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ (0)
EEQNPDTEFTNKNMLMTVIYLLFAGTMTVSATVGYTLLLLMKYPHVQ (1)
KRVREELTQELGSGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ (0)
GTEVFPLLGSILHDPSIFKHPEEFNPDHFLDADGRFRKHEAFLPFSL (1)
GKRVCLGEGLAKAELFLFFTTILQAFSLESPCPLDSLSLKPTISGLFNIPPAFQLQVRPTDLHSTTQTT*
CYP2S1 Bos taurus (cow)
See cattle page for details
MEAAGTWALLLLLLLLVVTLVLPATWDRGHLPPGPTPLPLLGNLLQLRPGALYLGLLR
LSKKYGPVFTVYLGPWRRVVVLVGHEAVQEALGGQAEEFSGRGTVATLDGTFDSH
GVFFSNGERWRQLRKFTTLALRDLGMGKREGEELIQAEARCLVEALQGTK
GRPFDPSLLLAQATCNIICSLVFDLRLPYDNEEFQAVVRAAGGIAVGVSSPWGQ
TYEMFSRFLQRLPGPHTQLLRHLGTVAAFAAQQVWQHKGSLGTSGPVRDLVDAFLLKMAK
EKQDPNTEFTAKNLLMTVVYLLFAGTVTVSTTIRYTLLLLLKYPQVQ
ERVQEELMRELGAGQRPSLGDRARLPYTDAVLHEAQRLLALVPMGIPRALTKTTRFRGYTLPQ
GTEVFPLLGSILHDPAVFEEPKEFNPGRFLDADGKFKKHEAFLPFSL
GKRVCLGEGLARTELFLLFTAILQAFSLEGPCPLGALSLQPAISGLFNIPQAFQLQFRPR*
CYP2S1 Sus scrofa (pig)
DT323081.1
85% to CYP2S1 cow
MEAAGTWALLLVLVLLLLLALALPGIRTGGHLPPGPAPLPLL
GNLLQLRPGAL
YLGLMRLSKKYGPVFTVYLGPWRRVVVLVGREAVQEALGGQAEEFSGRGMVATLDGTFDS
HGVFFSSGERWRQLRKVTMLALRDLGMGKREGEELIQAEAQRLVEEIRGTKGRPLDPSLL
LAQATSNIICSLIFGRRFPYDNEEFQAVVRAAGGTVVGVSSPWGQTYEMFSRVLQYLPGP
HTQLLGHLGTLAAFAVQQV
CYP2S1 Canis familiaris (dog)
NW_876270.1: 43044442-43033913
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
80% to human CYP2S1
MEAAGTWTLLLALLLLLLLLALARPRTRGHLPPGPPPLPLLGNLLQLRPGALYSGLLRLSKKYGPVFTVYLGPWR
RVVVLVGHEAVQEALGGQAEEFSGRGMLATLDGTFGGHGVFFSNGERWRQLRRLTTLALRDLGMGKREGEELIQA
EAQSLVEAFQGTVGRPFDPSLLLAQATSNIICSLTFGLRFPYEDKEFQAVVQAAGGTVLGVSSPWGQTYEMFSWL
LQHLPGPHTQLLSHLSVLATFAVQQVQRHKESLDTSGPPHDVVDAFLLKMAKEEQDPNTELTDKNLLMTVIYLLF
AGTVTVSTTVRYTLLLLLKYPQVQERVREELSRELGAGRAPGLGDRARLPYTDAVLHEAQRLLALVPMGVPRALA
RTTCFRGYTLPQGTEVFPLLGSVLHDPEIFDEPEEFNPDRFLDADGRFQKQEAFLPFSLGKRICLGEGLAHAELF
LLLTTILQAFSLESPSPPGALSLQPAVSGLFNIPPAFQLRVRP*
Cyp2s1 mouse
GenEMBL AA967201 ua50f06.r1 80% IDENTICAL TO HUMAN CYP2S1
AC073725.2, AC087155.1, NT_039407.1
AA967201 ua50f06.r1 80% IDENTICAL TO HUMAN CYP2S1
AA562979 vl64a09.r1
AA543966 vj69d06.r1
AA472776 vg94b11.r1
AI481433 vg94b11.x1
NT_039407.1 - strand
1933418 MEAASTWALLLALLLLLLLLSLTLFRTPARGYLPPGPTPLPLLGNLLQLRPGALYSGLLR 1933239
1931966 LSKKYGPVFTVYLGPWRRVVVLVGHDAVREALGGQAEEFSGRGTLATLDKTFDGHG 1931799
1928473 GVFFANGERWKQLRKFTLLALRDLGMGKREGEELIQAEVQSLVEAFQKTE 1928324
1925993 GRPFNPSMLLAQATSNVVCSLVFGIRLPYDDKEFQAVIQAASGTLLGISSPWGQ 1925832
1925752 AYEMFSWLLQPLPGPHTQLQHHLGTLAAFTIQQVQKHQGRFQTSGPARDVVDAFLLKMAQ 1925573
1924579 EKQDPGTEFTEKNLLMTVTYLLFAGTMTIGATIRYALLLLLRYPQVQ 1924439
1922453 QRVREELIQELGPGRAPSLSDRVRLPYTDAVLHEAQRLLALVPMGMPHTITRTTCFRGYTLPK 1922265
1920451 GTEVFPLIGSILHDPAVFQNPGEFHPGRFLDEDGRLRKHEAFLPYSL 1920311
1920154 GKRVCLGEGLARAELWLFFTSILQAFSLETPCPPGDLSLKPAISGLFNIPPDFQLRVWPTGDQSR* 1919957
>Cyp2s1-ie4b mouse
GenEMBL NT_039407.1 + strand 2s
internal exon 4 partial duplication
z in Figure 2B Nelson et al. Pharmacogenetics 14, 1-18 (2004)
1927805 QAASGTLIGISSP*GQ 1927852
2T Subfamily
CYP2T1 rat
No accession number
Lars von Buchholtz
Submitted to nomenclature committee 3/6/2000
73% to CYP2T2P
CYP2T2P human
GenEMBL AC008537
RAQMRGSLPPRPRPLPLLGNL
QLQSGGLDRALHSLSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADA
VSGRGSMAVFERFTRGNGILFSNRPCWWTLRNFALGALKKFGLGTRTVEA
RVLEEAACLLDEFQATIGAPFDPVRLLDNAVSNVICSLVFGNRYRYGDPE
FLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRIFRNFSE
LRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHGQQDPESHFQE*TSVM
TTHFFFGVTETTSTTLCYGLLILLKYLEVAAKVQELDPVVGWRPAPSL
DYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCLPKGTFVIP
LLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFAPAKQMCLG
TGLAHSGIFLFLTATLQRFCLLPVVRPGTINLTQCTGLGSVPPDFQLQPVAC
CYP2T2 Canis familiaris (dog)
chr1:115897947-115901169 UCSC browser May 2005 assembly
78% to mouse Cyp2t4
MFTALLLLLLLLLLLALARRSWGAQGTRTQGALPPGPTPLPLLGNLLQLESRRLDRALME (0)
LSGRWGPVFTVRLGPRPAVVLCGYSALRDALVLQADAFSGRGAMAVFERFTHGN
GIVFSNGLRWRTLRNFALGALKEFGLGTRTIEERILEEAACLLGEFQATT
GAPFDPRRLLGNAVSNVICSVVFGNRYGYEDPEFQRLLDLFNDNFRIMSSRWGE
MYNVFPTLLDWLPGPHHRIFQNFTELRVFISEQIQRHQQTRQPGKPRDFIDCFLDQMDK
EQNDPESHFQEETLVMTTHNLFFGGTETTSTTLRYGLLILLKYPEVA
AKVQAELDAVVGQSRTPRLGDREHLPYTNAVLHEIQRFISVLPLGLPRALTRDTHLHGYFLPK
GTFVIPLLVSSHRDPTQFKDPDCFNPTNFLDDKGEFQTNDAFMPFAP
GKRMCLGAGLARSEIFLFFTAILQRFCLLPVGNPANIDLSPQCTGLGNIPPAFQL
RLVAR
CYP2T2P ortholog Bos taurus (cow)
See cattle page for details
MMISGIIALSLLVLLLAPARWGWGARSTQRQGALPPRATPLRLLGSLLQLRIWRPGPCTHG
LSGRCGPVFTVCLGQCPVVVLCRYAALRDALVLQADAFSGRGAMAVFKRFTRGN
GIAFSKGPRWPTLRNFALGALKEFGLGTQTIEERVLEEAACLLGDFQATGG
GAPFDPQRLLDNAVSNVICSVVLGNHYGYEDMEFLRLLDLFNDNFRIMSSRWGE
XXXXXSLLDWLPGLHH*IFRNFAXLRVFISQQIQLHQQTR*SGKPHDFIDXXXXXXX
GTENPESHFQAETLAMTMHNLFFGXXETTSTTLRYGLILLKYSFVA
AKVQAELDDMVGRMCAPTLEDREHLPYTNTVLHEIQCFISVVPFGLPSALTCDTHLRGYFLPK
GTFVIPLLVSTHWVPTQFKNPECFNPTNFLNDQGEFQSNAFTPFAL GTCLGAGLAPTDIFLFLTSILLRFFLLPVGSHSDTDLTPQCTGLGNVPPAFQLRLVAR*
CYP2T3P human
GenEMBL AC008962 C-terminal missing
RAQMRGSLPPRPRLLPLLGNLQLQSGGLDRALHS
LSGRWGRVFTVRLGPRPAVVLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN
GILFSNRPCWWTLRNFALGAPKKFGLDTRTIEARVLDEAACLLDEFQATI
GAPFDPVRLLGNAVSSVTCSCLREPLWLRGPGVPEVLNLLSDNFRIMSSKWGE
SLMDWLPGPHHQIFQNFSELQVFISEQIQQHWHMRQPAEPRDFIDCLARWVRHG
QQDPESHFQEETLVMTMQLFFFFFFGGTETTSTTLC
AKGQELDPVVGQRPVPSPD
DHVQWPYTNAVLLEIQRFISVVPRTLTLDTHLHSHCLAKG
Cyp2t4 mouse
GenEMBl NT_039413.1 + strand
157707 MVTCLALLLLLLILMLLLWWGGVVRRQAQMQKDLPPGPAPLPLLGNLLQLQSGDLDRVLME 157889
158219 LSSHWGPVFTVWLGPLPAVVLCGYEALRDALVLQADAFSGRGAMAVFDRFTCGN 158380
158742 GIVFSNGPRWHSLRNFALGVLRELGVGRSTIEDRILEEAACVLDEFQATM 158891
159103 GAPFDPQQLLDSAVSNVICTVVFGKRYDYGDPEFRRLLNLFSDNFCIMSSRWAE 159264
159884 IYNMFPSFMDWIPGPHNRIFKNFQELRLFISEQIQWHWQSRQTGEPRDFIDCFLDQMDK 160060
160137 EQQDLESHFQDETLVMTTHDLFFGGTETTSTTLRYGLLIMLKYPEVA 160277
160379 AKVQEELDATVGRTWAPRIEDRARLPYTNAVLHEIQRFISVLPLGLPRALTRDVNLKNHFLHK 160567
160818 GTFVIPLLVSAHRDPTQFKDPDHFNPTNFLDDHGEFQNNDAFMPFAL 160958
161048 GKRMCLGAGLARSEIFLFLTAILQKFSLLPVGSPANINLNPQCTGLGNVPPAFQLRLVAR* 161230
2U Subfamily
CYP2U1 human
AC025090, (AC000016 has C-term) 41% to 2N1 new CYP2 subfamily
MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGI
77036 PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSI 76863
76862 FSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT 76734
105008 GPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPF 105160
105161 SIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPF 105340
105341 GPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEE 105517
105518 YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ 105622
107396 KVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENT 107554
109370 LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIG 109540
KRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR
CYP2U1 Macaca mulatta (rhesus monkey)
note gc boundary between exons 7,8
MSSPGPPQPPAEDPPWPARLLRAPLGLLRMDPSGDALLLCGLVAVLGWSWLRRRRARGIP
PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVVGPQVLLAHLARVYGSIFSF
FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEK (1)
GVVFAHYGPIWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI
ISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLMVNICPWLYYLPFGP
FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLF
YIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ (1)
EKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSGNT (1)
VLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGI (1)
GKRVCMGEQLAKMELFLMFVSLMQSFAFALPEKSKKPLLTGRFGLTLAPHPFNITISRR*
CYP2U1 Bos taurus (cow)
See cattle page for details
MASPGLPQPPTEDAAWPLRLLHAPPGLLRLDPTGGALLLLVLAALLGWSW
LWRLPERGIPPGPAPWPVVGNFGFVLLPRFLRRKSWPYRRARNGGMNASGQGVQLLLADL
GRVYGNIFSFFIGHYLVVVLNDFHSVREALVQQAEVFSDRPRVPLTSIMTKGKGIVFAHY
GPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSN
IICSLCFGRRFDYTNSEFKQMLTFMSRALEVCLNTQLLLVNICSWLYNLPFGPFKELRQI
EKDLTLFLKKIIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNSGFDEDYLFYIIGDLF
IAGTDTTTNSLLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMPYTEATIMEV
QRLSTVVPLSIPHMTSEKT
VLQGFTIPKGTIILPNLWSVHRDPAIWE
KPNDFYPDRFLDDQGQLIKKETFIPFGI
GKRVCMGEQLAKMELFLMFVSLMQSFTFVLPKDSKPILTGKYGLTLAPHPFNIIISKR
CYP2U1 Canis familiaris (dog)
NW_8762971.1:28366254- 28348146
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
75% to human CYP2U1
WLHRRTPVAAAGGAAGAGGHSSARGPQLLLADLARAYGAVFSFFIGRHLVVVLSDFRSVRAALVQQAEIFSDRPR
VPLVSLVTKEKGIVFAHYGPVWKQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKEEMQKHGEDPFNPFPIVNNA
VSNIICSLCFGQRFDYTNSEFKKMLRLMSRALEICLNSQLLLVNICSWLYYLPFGPFKELRQIEKDITTFLKKII
KDHKESLNVENPQDFIDMYLLQVEEERKNNSNSSFNEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDIQEK
VQEEIERVIGADRVPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSEKTLQGYTIPKGTVILPNLWSVHRDP
AIWEKPDDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFALPKDSKKPILTGRY
GLTLAPHPFNIVISKR*
Cyp2u1 mouse
GenEMBL AK018458 16 days embryo lung cDNA about 78%
MSSLG DQRPAAGEQPGARLHVRA TGGALLLCLLAVLLGWVWLRRQRACGI
PPGPKPRPLVGNFGHLLVPRFLRPQFWLGS GSQTDTVGQHVYLARMARVYGNI
FSFFIGHRLVVVLSDFHSVREALVQQAEVFSDRPRMPLISIMT
KEKGIVFAHY
GPIWKQQRRFSHSTLRHFGLGKLSLEPRIIEEFAYVKEAMQKHGEAPFSPF
PIISNAVSNIICSLCFGQRFDYTNKEFKKVLDFMSRGLEICLHSQLFLINICPWFYYLPF
GPFKELRQIERDISCFLKNIIREHQESLDASNPQDFIDMYLLHMEEEQGASRRSSFDED
YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ
KKVHEEIERVIGCDRAPSLTDKAQMPYTEATIMEVQRLSMVVPLAIPHMTSEKT
VLQGFTIPKGTVVLINLWSVHRDPAIWEKPDDFCPHRFLDDQGQLLKRETFIPFGIG
CYP2U1 Xenopus tropicalis (frog)
See Xenopus page for seq
CYP2U1 Danio rerio (zebrafish)
CYP2U1-de1b Danio rerio (zebrafish)
CYP2U1 Fugu rubripes (pufferfish)
No accession number
Scaffold_8899
56% to human 2U1
MMSLSWLQSLSSSILTLVIMIILHHLFKCYQKRHGFANIPPGPKPWPVVGNFGGFL (0)
NAAAVLTELAKVYGNVYSIYVGSQLVVVLNGYKVVRDALSNHPDVFSDRPDIPA
ISIMTKISGIVFAPYGPLWQKHRRFCLSTLRNFGLGRLGLEPCIVEGLTNIKTELLRLE
EESGGAGVDPAPVISNAVSNVICSLVLGHRFNHDDQEFRSMLRLMDRGLEICVNSPAVLI
NVFPLLYHLPFGVFRELRQVERDITAFL
KRFIANHQETLDPNNPRDLTDMYLKEISARREAGDVDSGFTED
YLFYIIGDLFIAGTDTTANSVLWVILYMASYPDIQ
KVQAEIDGVVGPLRTPSLSDKGKLPFTEAAIMEVQRLTTVVPLAIPHMTSET
EFMGYTIPKGTVVLPNLWSVHRDPTEWDDPDSFDPTRFLDEDGTLLRKECFIPFGIG
RRVCMGAQLAKMELFLTVTNLLQTFHFRLPEGAPRPPLQGRFGLTLAPCPYTVCINPR
CYP2U1 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr IX (-) strand 8019744-8022277
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
73% to Fugu 2U1
MASLSWPSGADLSRVDVVALLLASLLLALCLFDVHRRRRDLANIPPGPTPWPLVGNLGFSLVPALFRRRFGEKPV
DKNAMVLLTERAAVYGNVYSMFVGSQLMVVLNGYEAVKDALSNHPEVFSDRPDIPAITIMTKRKGIVFAPYGPVW
RKQRKFCHTTLRSFGLGKLSLEPCIQQGLTTVKTELLHLSKKSGATGVDPAPLISNAVSNVICSLILGQRFHHED
RQFRSMLDLMDRGLEICVSSPAVLINVFPLLYYWPFGVFRELRRVEGDITAFLKRIIATHRETLDPDNPRDLVDM
YLMEMSAQQAAGEEDSSFTEDYLFYIIGDLFIAGTDTTANSVLWVLLYMVLHPDIQDKVQTEMDEVVGTHRTPSS
TDKGSLPFTEATIMEVQRMTVAVPLAIPHMASETTEFRGYTIPKGTVIVPNLWSVHRDPTVWDEPDRFNPARFLD
EEGQLLRKECFIPFGIGRRVCMGEQLAKTELFLTVTSLLQAFRFRLPEGAPPPSLTGRFGLTLAPCPYAVCVSPR
G*
CYP2U1 Oryzias latipes (medaka)
chr1 20316302:20324749
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
66% to Fugu 2U1
MVSSSFGLIWSSVLSLSNLLTSLLFLLVYYLVRFYQKQRTIYKNIPPGPKPWPVVGNFGNFFVPPSVRTKIAGQP
NSTNAIEIEALRQQATVFGNIHSLFIGGQLIVVLHGFHLIRDALLNQPEVFSDRPDIPLVTILTKRKGIVFAPYG
PVWRKQRKFCHTTLRSFGLGKLSLEPCIQRGLAGVKAELLRLNEERGSAGVDPATLIGNSVSNVICSLILGQCFH
HHDVEFRTMIRLMEHGLKICINSPAVLINIFPLLYYLPFGVFKELRQVERDITAFLKRIIAKHRDTLDPDNPRDL
TDMYLIEMLTQQAAGEEDSSFTDDYLFYVIGDLFIAGTDTTTNSILWFLLYMILHPDVQDKAQAEIDGVVGKHRV
PSVTDKGSLPFTEATIMEVQRLHSVVPLAIPHMTSETTVFRGYTIPKGTVIFPNLWSVHRDPTLWEDADSFNPSR
FLDNEGNLLRKEYFIPFGIGRRVCMGEQLAKMELFLTVTTLLQAFKFRHPEGNPPPTVKERFGLTMAPCPFSVCV
TPRGGPNLNP*
2V Subfamily
CYP2V1 Danio rerio (zebrafish)
GenEMBL AB026158
Ohta,M., Saitou,T., Yoshizaki,G. and Otsuki,A.
Identification of a Cytochrome P450(CYP2) cDNA for Zebrafish
Also found as an EST from Yea-Huey Yang, Jun-Lan Wang-Buhler and
Donald R. Buhler Submitted to nomenclature committee 7/1/2000
Note: AB026158 has at least 2 frameshifts and some
other probable errors. Buhler‚s sequence seems to be more
accurate.
CYP2V1 Danio rerio (zebrafish)
No accession number
Tseng, H.-P., Wang-Buhler, J.-L., Yang, Y.-H.,
Hu, C.-H., Buhler, D.R.
submitted to nomenclature committee 12/08/2003
51% to CYP2Z2
clone name YH-F4-FL
2W Subfamily
CYP2W1 human
GenEMBL AC073957.3 chromosome 7
clone RP11-449P15 40% to 2F1
MALLLLLFLGLLGLWGLLCACAQDPSPAARWAPGLRPLPLVGNLHLLRLSQQDRSLME
LSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRP
PIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQL
DGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL
FNVHPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQG
DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP
GRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLT
SVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSA
GRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRPRALCAVPRP*
CYP2W1 Macaca mulatta rhesus monkey
AC073957.7 chromosome 7
LSERYGPVFTVHLGCQKTVVLTGFEVVKEALAGPGQELADRPPIAIFQLIQRGG (1)
GIFFSSGARWRAARQFTVRALHSLGVGRKPVADKILQELKCLLGQLDGYR (1)
GQPFPLALLGWAPSNITFTLLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQ (0)
LFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHMRPGDPVCSYVDALIQQGQ (0)
GDDPEGLFAEDNAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQ (1)
GRVQEELDRVLRRGRPPQPEDQQVLPYTSAVLHEVQRFITLLPHVPRCTATDMQLGGFLLPK (0)
GTPVIPLLTSVLLDETQWQTPDQFNPGHFLDADGHFVKQEAFLPFSA (1)
GRRVCVGERLARTELFLLFAGLLQKYYLLPPPGVSPASLDTTPAQAFTMRPRAQALCAVPRP
CYP2W1 Bos taurus (cow)
See cattle page for details
Partial seq.
LGKQYGPVFTVHLGHQKTVVLTGYEAVKEALVGTGQELAGRPPIAIFQLINGGG (1)
GVFFSSGPRWRAARQLTVRALHGLGVGRAPVANKVLQELRCLTAQLDSYE (1)
GRPFPLALLRWAPSNITFTLLFGQRFDYRDPVFLSLLGLVDEVMVLLGKPSVQ (0)
LFNLYPRLVALLQLHRPVLRKIEEVRAILRALLEARRHRTPPRGPQQSYLDALIQQGQ (0)
XXXXX
XXXXXXXXXXXXXXXXPRPEDVHALPYTNAVLHEVQRFITLLPHAPRCTVANTQLGPYLLPK
GTPVLALLNSVLLDETQWKTPRQFNPGHFLDANGRFVKRPAFLPFSA
CYP2W1 Canis familiaris (dog)
NW_876319.1: 293563-287849
Joanna Wilson and students
submitted to nomenclature committee Feb. 17, 2009
83% to human CYP2W1
MALLLLGILLLLGLWGLLRTCTRTPSSASRWPPGPRPLPLIGNLHLLRVSQQDQSLMELSEQYGPVFTVHLGRQK
TVVLAGYEAVREALVGTGPELADRPPIAIFQLIQGGGGIFFSSGARWRAARQFTIRTLHGLGVGRGPMADNVLQE
LRCLMGQLDCYRGQPFPLALLGWAPSNITFTLLFGRRFDYQDPVFVSLLSLIDEVMVLLGTPSLQLFNIYPWLGA
LFQLHRPVLRKIEEVRAILRTLLKARRPSMPGGGPVQSYMDALIQQGQGKDPQGLFAEANMVACTLDMVMAGTET
TSATLQWAALLMGKHPSVQCRVQEELDRVLGPGRAPQLEDQRSLPYTNAVLHEVQRFITLLPHVPRCMAADTQLG
GYLLPKGTPVIPLLSSVLLDKTQWETPRQFNPGHFLDAEGRFVKRAAFLPFSAGRRVCVGESLARSELFLLFAGL
LHRYRLLPPPGLSPDALDTTPAPAFTMRPPAQALCAVPRPGGYDQGDWGRV*
The following cDNA AK000366.1 has been reported from Japan in a project to
identify Full length cDNAs. This is a part of the 2W1 gene. The reported
sequence shown below is not full length. It is missing the N-terminal
exon and the C-terminal exon. If one translates the sequence upstream of
the ATG shown below, one finds the N-terminal exon sequence as shown
above, however, there are only about 7 amino acids worth before the
sequence runs out and stops. Similarly, if the genomic clone is searched
downstream of the end of the cDNA, a clear heme binding sequence is
found and another exon is identified. The last exon has a problem. It
is too long if allowed to run until it hits a natural stop codon.
However, in another frame there is a sequence LCAVPRP* that is identical
to the end of CYP2D6 and this sequence is at the right location for this
to be the end of the 2W1 gene. I suspect there is a frameshift between
the heme binding region and the LCAVPRP* sequence. I have shown the 2W1
gene with this frameshift, though the exact location is uncertain.
Cyp2w1 MOUSE
GenEMBL XM_144624 WHOLE mRNA
PARTS from GSS AZ515172 AZ329864 AZ983190 BH076787
MALLLLGVWGILLLLGLWGLLQGCTRSPSLAPRWPPGPRPLPFL
GNLHLLGVTQQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADR
PPIPIFQHIQRGGGIFFSSGARWRAGRQFTVRTLQSLGVQQPSMVGKVLQELACLKGQ
LDSYGGQPLPLALLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQ
LFNTFPRLGAFLRLHRPVLSKIEEVRTILRTLLETRRPPLPTGGPAQSYVEALLQQGQ
EDDPEDMFGEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLG
PGQLPQPEHQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLL
TSVLLDKTQWETPSQFNPNHFLDAKGRFMKRGAFLPFSAGRRVCVGKSLARTELFLLF
AGLLQRYRLLPPPGLSPADLDLRPAPAFTMRP (end may be frameshifted)
PAQTFSYDSVYSGAKAAYPYVEVGSWPFIWHHGAEGVSAQCSGPTLS
2X Subfamily
CYP2X1 Ictalurus punctatus (catfish)
GenEMBL AF315346.1
Schlenk,D., Furnes,B. and Zhou,X.
Isolation and cloning of a new P450 2 family gene from Ictalurus
Punctatus.
Unpublished
42% to 2N2
CYP2X2 Fugu rubripes (pufferfish)
No accession number
Scaffold_4007
MVTSVILLCLGVVVLVLLLRSQRPKNFPPGPPVLPLLGSILELALDNPLQDFER (0)
12453 LRKKYGNVYSLFLGTRPAVVISGLKNIKEALVTKGSDFSGRPQDMILSI 12629
possible frameshift DAIKTN (1)
13208 VIMQDYNLVWKEHRRFALTTMRNFGMGKTSMEDRIHGEIEYIVNTLEKNN (1)
GKTLSPHLMFHNAASNIICQVLFGTRYEYDDHFIREIVRCFTENAKISNGPWAM (0)
LYDSIPLVRYLPLPFKNAFKNVE (0)
TAENLVKDLFVEHKKTRMSGDPRDFVDCYFDELDK (0)
RGKDRSSFSENMLTMYALDLHFAGTDTTSNTLLTGFLYLMNYPHIQ (1)
ERCHQEIDKVLQDNETVTYDARNQMPYMQ (0)
15630 AVIHEVQRVANTVPLSVFHCTTKDTEFMGYSIPK 15731 (0)
15853 GTLIIPHLASVLKEEGQWKFPNEFNPDNFLNDDGEFVKPEAFMP 15984 (frameshift) XST (1)
16100 GPRVCLGEGLARMELFLIIVTLLHKFQFIWPEDAGEPDYTPIFGATQTPKPYRMKIQLRK* 16282
CYP2X3 Fugu rubripes (pufferfish)
No accession number
Scaffold_10845
missing exons 1-4 off the end of the scaffold
7527 LYDSFPAVRYLPLPFKRGFEMFK 7450 (0)
7381 MSHERYLEMFVETKKTRVPGKPRHFVDAYMDELEK 7277 (0)
7193 RGDEAFFSEDQLCAIILDLHFAGTDTTANTLLSGLLYLMKYPHIQ 7057 (1)
6289 EYCQQEIDKVMQGKNEVSFEDRVQMPYVQ 6203 (0)
6105 AVIHEIQRTANTVPLSVFHCTTRDTELMGYSIPK 6004 (0) exon 9
5617 GTLIIPNLSSVLNEKGQWKSSHEFNPENFLNENGEFVQPEAFMPFST 5477 (1)
5244 GPRVCLGEGLARMELFIILVSLLRKFRFIWPEDAEEPDLTPVFGVTQTPKPYSLKVQVRSRC* 5056
CYP2X4X Fugu rubripes (pufferfish) discontinued name
No accession number
FE:EFRy002apsE4 EST exons 10 and 11
Length = 458 395-496 51% to 2D6 87% to Scaffold_10845 (CYP2X3)
Note: this EST is not in the current Fugu databases and appears to have been
removed. It may have been a poor quality sequence of CYP2X3 (March 2, 2005)
SSPKGTIIIPNLSSVLNEKGQWKCPHEFHPGNFLNENGEFVKPEAFVPFST
GPRVCLGEGLARMELFIILVTLLRRFKFIWPEDAEEPDLTPIFGLTQTPKPYRLKVQIRSSFK*
CYP2X5P Fugu rubripes (pufferfish)
No accession number
Scaffold_3538 57% to FE:EFRy002apsE4 51% to 2D6 Length = 26272
61% to 2X2 59% to scaf 10845 (CYP2X3)
first 8 exons missing off end of scaffold
E in EXXR motif missing, one bad boundary, no exon 11 found
Possible pseudogene
25728 (0) PGIHKVQRIANTVPLNVQYCTMKETQLMAHLLPR 25627 exon 9 bad boundary
25349 (0) ETLIIQNLNSRQNEEGQWKFPHKSRPENFLNDQGEFVKTEDFMLFSA 25209 (1) exon 10
CYP2X6 Danio rerio (zebrafish)
ctg22265.a 66% to CYP2X1
708019 MLGSSLLVVICILLIFFLIRVKKPKNFPPGPPPVPIFGNLLQLNLANPLKDFEK 707858
707784 FAEKYGEIFSLYTGSRPAVILNSFAVIKEALVTKAQDFSGRPQDFMISHATENKGN 707617
705571 IVLADYGPVLKGHRRFALMTMRNFGLGKQSMEERILGEISHVVDYLDKNA
GKRVDPHIMFHNVASNVISLLLFGCRFDYNSEFLQCYIQLINEISKIINGPWNM 705149
703459 IYDTFPLLRILPLPFKKAFDHVKVIKSMNLKLIDEHKSTRVPGEPRDFIDCYLDELDK 703286
703161 GKNCVSTFSEDKLLMSIMDLHFAGTDTISNTLLTAFLYLMNHPEVQ 703024
702766 VKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTELMGYSIPK 702578
702500 GTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQFEKPEAFIPFST 702360
701098 GLRMCLGEGLARMELFLIFVTLLRRFQFVWPEDAGKPDYTPVFGLTLTPKPYRMHIRRRETVKQ* 700904
CYP2X7 Danio rerio (zebrafish)
ctg22265.b CYP2X1 Missing C-term
BC053412 AI959373 fd08g05.y1 CK030199 AI959373
zfishC-a2684d06.q1c
ctg11087 = BC053412 FILLS IN exons 3,4 in a GAP IN ctg22265
718880 MLEVSVLILICIFLVFFLIRIKRPKNFPPGPPPVPIFGNLLQINMVDPLKEFER 718719
718641 LAEKYGNIFSLYTGSKPAVFLNNFEVIKEALVTKAQDFSGRPQDLMISHL 718492 TGNKG
670408 VVLADYGPLWKDHRRFALMTLRNFGLGKQSMEERILGEISHIVDFLDKNT 670557
670648 GKTVDPQIMFHNIASNVINLVLFGCRFDYNNEFLRGYIQRIAENLRILNGPWNM 670809
717005 IYDTFPLLRILPLPFKKAFDNVKIIKSMNRKLIDEHKSTRVPGQPRDFIDCYLDELDK 716832
716723 VKNCVST 716703 716703 FSEDQLIMNIMDMSFAGTDTTSNTLLAAFLYLMNHPDVQ ()
716439 VKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANIVPLSVLHCTTRDTELMGYSIPK 716251 ()
716170 GTVIIPNLTVVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFST 716030
713418 GPRVCLGEGLARMELFLIFVTLLRRF 713341
QFVWPEDAGKPDYTPVFGLTMTPKPYRMHIRRRNTVKQ
CYP2X7-de9a Danio rerio (zebrafish)
ctg22265.c CYP2X1 pseudogene? C-term 92% to 2X.b zfish41361-135c06.q1c
zfish45283253h10.q1k zfish43795-291e06.p1c
720930 LGEGLARMELFLVFVTLLRRFQFVWLEDAGKPDYTPVFRHTMTPKPYRMHIRRR 720769
CYP2X7-de9b Danio rerio (zebrafish)
ctg22265.d CYP2X1 pseudogene? C-term 87% to 2X.b
727710 GPRVCLGEGLARMELFLVFVTLLRRYKFVWPRDAGKPDYTPVFGITMTPKPYRMLIRRRDTVQ 727519
CYP2X8 Danio rerio (zebrafish)
ctg21275 87% to 2X.a
1267572 MLGSSVLVLICILLVFLLIRIQRPKNFPPGPSPLPIFGNLLHFNLANPLKEFER 1267411
1267339 FAEKYGNIFSLYTGSRPAVFLNSFAVIKEALVTKAQDFSGRPQDFMISHLTECKGN 1267172
1263893 VVLADYGPLWKDHRRFALMTLRNFGLGKQSMEERILGEISHVVGYLDKNI 1263744
1263630 GKTVDPQVMFHNVASNVISLVLFGRRFDYNSETLQCYIQLITEISKILNGPWNM 1263469
1262072 IYDTLPFLRILPLPFKKGFDHVKVLKGMNLKLIDEHKSTRVPGKPRDFIDCYLDELDK 1261899
1261775 RKNEVSTFSEDQLLMYILDLYFAGTDTTSNTLLTAFLYLMNHPEVQ 1261638
1261335 VKCQQEIDDVLEGKDQVSYEDRDNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTELMGYSIPK 1261147
1261074 GTLIIPNLTIVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFST 1260934
1269368 GPRVCLGEGLARMELFLVMVTLLRRFQFVWPNDAGKPDYTP
1269244 VYGVTLTPQPYRMHIKRRETVRX 1269179
CYP2X9 Danio rerio (zebrafish)
ctg9731 exons 1-4 67% to 2X6 first 39 aa = 2X6 100%, FRAMESHIFT IN EXON 3
66640 MLGSSLLVVICILLIFFLIRVKKPKNFPPGPPPVPIFGNMLQLNINNPLKDFER 66479
66305 LANRYGNIYSLYFGSKPWVVLNGFEALKEALVTKAVDFAGRPQDLMVNRVTKGGGE 66138
65961 VILSDYGPSWKE HRRFALMTLRNFGLGKQSMEERILGEVSHIIDKLEKR 65819
65727 GTAFDPQTMFHNAASNIICIVLFGSRYDYDDEFLKLFIHLYTENAKIANGPWAM 65566
ctg21275 exons 5-9 77% to 2X.b trace CF996180 joins these two contigs
1272272 IYDTFPMFRYLPLPFRKAFANASKARELSTQLVEEHKKTWVPGEPRDFIDCYLDELDK 1272099
1271302 RGNDGSSFSEAQLILYVLDLHFAGTDTTSNTLLTGFLYLMTHPEVQ 1271165
1269858 AKCQQEIDDVLEDKDQASYEDRHSMPYTQAVIHEVQRVANTVPLSVFHCTTKDTELMGYNIPK 1269670
1269601 GTFVIPNLGSALKEEGQWKFPHEFNPANFLNEQGEFEKPEAFVPFSA 1269461
1259306 GPRVCLGEGLACTELFLVFVTLLRRYKFVWPRDAGKPDYTPVFGITMTPKPYRMHIRWRNTVKQ 1259115
CYP2X10 Danio rerio (zebrafish)
ctg24117.a 55% to 2X.b
57088 MLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKDFD 56930 (0)
56850 KFAQHYGSIYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGK 56686 (1)
56439 GVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESA 56287 (1)
56129 GKSIDPQHLYHQAASNIIASIIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAM 55968 (0)
55706 LYEIAPVLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEMEN 55533 (0)
55465 KSDHRTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQ 55328 (1)
54962 EQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPK 54774 (0)
54580 GTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSA 54440 (1)
54228 GPRVCLGENLARMELFLILVTVLRRFRLVWPKDAGEPDFTYIYGGTQSVKPYRVIVEPRMHGEACKFVD* 54019
CYP2X10 Danio rerio (zebrafish)
GenEMBL AY825256
Tseng, H.-P., Corely-Smith, C., Hu, C.-H., Wang-Buhler, J.-L.,
Hseu, T.-H., and Buhler, D.R.
Submitted to nomenclature committee Oct. 14, 2004
Clone 898HuHP
MLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLN
RISPLKDFDKFAQHYGSIYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFS
HVTGGKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAG
KSIDPQHLYHQAASNIIASIIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAMLYEIA
PVLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEMENKSDHR
TSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHV
TYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPKGTIIIPYLSSSL
REESQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVL
RRFRLVWPKDEGEPDFTYIYGGTQSVKPYRVIVEPRMHGEACKFVD
CYP2X11 Danio rerio (zebrafish)
ctg24117.b zfishI-a36g12.q1c EXONS 1-7 85% to CYP2 Length = 544
80259 MLTALVLLCLGAFLLYLQVRIRRPKDFPPGPAPVPFFGNLLQLNRINPIKDLDK 80420
80510 FAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGS 80677
80848 VIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESA 80997
82938 GKSIDPQHLYHQAASNIIASVIFGSRFNYKDEYFQTLIQTMEKLTKIAIGTWAM 83099
83317 LYEIAPVLRIFPLPFWKAFHYFEKITRHSLKVVEEHKKSFVAGEPKDLIDCYLEEMKK 83490
83572 RADQRTTFDEAQMVTLLFDLYLAGTETTSNTLRTLTLF 83685
88976 EQCQREIDEVLGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQLRGYSIPK 89164
92540 GTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSA 92680
92791 GPRVCLGENLARMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPMIVKLR 92967
CYP2X11-de1 Danio rerio (zebrafish)
ctg24117.c EXON 1
94557 MLTALVLLCLGAFLLYLQLRIRRPRNFPPGPAPVPIFGNLLQLNHINPIKDLDK 94718
CYP2X12 Danio rerio (zebrafish)
GenEMBL AY825257 EST partial seq CN509498.1
Tseng, H.-P., Corely-Smith, C., Hu, C.-H., Wang-Buhler, J.-L.,
Hseu, T.-H., and Buhler, D.R.
Submitted to nomenclature committee Oct. 14, 2004
Clone s898HuHP full length seq.
91% to 2X10
MLTALVLLCLGAFLLYLQLRIRRPRNFPPGPAPVPIFGNLLQLN
HINPIKDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVS
HVTRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAG
KPIDPQHLYHQAASNIIASIIFRSRFDYQDEYFQTLITTMEKLTKIAIGPWAMLYEIA
PVLRIFPLPFHKAFQYFEQITNHVLKVVEEHKTSRVAGEPRDLIDCYLEEMNRRSDKH
TTFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHV
TYEDRNAMHFVQAVIHEGQRVADIVPLSMFHTARTDTQLRGYSIPKGTIIIPYLSSSL
REEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSAGPRVCLGENLARMELFLILVTVL
RKFRLVWPKDAEEPDFTYIYGGTQSLKPYPMIVKLRTPGETHEYAK
CYP2X13 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr XIX (-) strand 19940206-19948532
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
72% to Fugu 2X2
MFASIILLLICIVFIVIQLKSRRPKNFPPGPPVWPILGNILDLSLENPLKDFERLRKTYGNVYSLFLGPKPVVVI
NEMKTIKEALVTKGVDFAGRPQDLLINDSSERELVMTDYGSSWKEQRRFALMNLRNFGMGKDSMEERIHGEIQYT
VDTLEKSIGKSFSPQNMFHNAASNIICQVLFGKRFEYEDETIKTVVQCFTENAKIANGPWAMIYDSFPLIRSLPL
PFRRAFKNVETCRKIAKSLMNEHKQTRVPGEPRDFVDCYLDRLDK (0)
PGDRSSFSEAQLTMYILDLHFAGTDTTSNTLLTGFLYLMNYPHVQ (1)
EPVFKYGNMIFKYFFI
ERCQQEIDMVLEGKDQASSEDRNNMPYVQ (0)
AVIHEFQRVANTVPLSIFHSTTKDTELNGYSIPKGTLIIPNLT
SVLNEEGQWKFPNEFNPENFLNDQGEFVKPEAFMPFSAGPRMCLGEGLARMELFLFTVTLLRKFKFIWPEDAGEP
DFTPVYGVTLTPKPYRMKVQLRVSQKIPH*
CYP2X14 Oryzias latipes (medaka)
chr6 21423000:21438000
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
67% to Fugu 2X2
MFVSLILLWLCICILFLQLKPRRPKNFPPGPPVLPMLGNLLHLSLDNPLKDFDRLRNSYGNVYSLFLGPKPAVII
NGFKAMKEAMVIKATDFAGRPQDLFVNDVSKRKGVILADYGESWRDHRRFALMTLRNFGLGKKSMEERISEEIQH
TIKTLENNIGKLFSPQIMFHNAASNIICQVLFGKRFEYDDEIIKTIVQCFTRNSKIANGPWAMIYDSIPLIRKLP
LPFREAFKNAEICVDVGTHLVNEHKETRIPGKPRDFVDCYLDEMEKVRGDDSSFSEDQLIIYALDLHFAGTDTTS
NTLLTGFFYLINYPHIQDKCQQEIDRVLEEKQQVTFEDRHNMPYMQAVIHEVQRIANTVPLSVFHSTTKETELMG
YTIPKGTMIIQNMGSVLREDGQWKFPHDFNPENFLNEKGEFVKPEAFMPFSAGPRMCLGEGLARMELFIIMVTLL
RKFKFTWPEDAGEPDFTPVYGVTLTPKPYFMKVQLRSKP*
CYP2X fragment a Fugu rubripes (pufferfish)
No accession number
Scaffold_9193 Length = 9721 51% to scaf 4007
possible exon 1 of 2X3 or 2X4
LGL47087.y1 Length = 725 2 family N-term exon 1
333 MLVSLALLLAAAFGLWVFFQIQRPKNFPPGPPPIPLFGNLLEIQLDNPIADLER 172 (0)
CYP2X fragment b Fugu rubripes (pufferfish)
No accession number
possible exon 2 of 2X3 or 2X4
LED83776.x1 75% to scaf 4007 exon 2 not in new version of fugu databases
LAKRYGNVYGLFLGSRPAVVINGVSAL
2Y Subfamily
CYP2Y1 Fugu rubripes (pufferfish)
No accession number
Scaffold_39a from an early version of the genome
12087 MDLTVMLLTATLLLVVLWILNAHTRKHTRLPPGPRGIPVLGNLLQLDKKAPFKSLLK 11917 (0)
11768 LSENYGPVLTVALGPQRTVVLVGYEAVKDALVDHADDFTGRGPVPFLMKVTRGY 11607 (1)
11166 GLAISNGERWRQLRRFTLTTLRDFGMGRKGMEEWIQEESKHLVTRIKSTE 11011 (1)
10937 GAPFDPTFFLSCTVSNVICCLVFGQ 10869 frameshift
10867 GFSYDDEHFLSLLHIISETIQFGSSASGL 10781 (0)
10700 MYNLFPRLMEWLPGRHREMFGKIEKVRAFTMEKIEEHQDTLDPSSPRDYIDCFLMRLQQ 10524 (0)
10452 EKPQPNTEFNYDNLVSTVLNLYLAGTETTSSTIRYALNVLIRHPKIQ 10312 (1)
10187 EKMQEDIDSVIGQGRCPYVEDRKSLPFTDAVLHEIQRYLDMIPFSIPHYALQDISFRGYTIPK 9999 (0)
9924 DTLIIPLLHSVLKDDKMWETPGSFN 9850 frameshift
9850 PLQHFVDGNGSFKKNPAFLPFSAG 9779 (1)
9687 GKRACVGESVARHGDIPSLSSHLVQHFTLSX 9595 frameshift
9593 PGGPDSVDLTPEYSSFANVPRKYKIIATPRCNKRLCIVI* 9471
GenEMBL CAAB01000830 WGS section of Genbank 25-JUL-2002
Note: the frameshift in exon 7 did not exist in the earlier version above
This is probably a sequence error
19218 MDLTVMLLTATLLLVVLWILNAHTRKHTRLPPGPRGIPVLGNLLQLDKKAPFKSLLK (0) 19048
18899 LSENYGPVLTVALGPQRTVVLVGYEAVKDALVDHADDFTGRGPVPFLMKVTRGY (1) 18738
18297 GLAISNGERWRQLRRFTLTTLRDFGMGRKGMEEWIQEESKHLVTRIKSTE (1) 18148
18074 GAPFDPTFFLSCTVSNVICCLVFGQRFSYDDEHFLSLLHIISETIQFGSSASGL (0) 17913
17832 MYNLFPRLMEWLPGRHREMFGKIEKVRAFTMEKIEEHQDTLDPSSPRDYIDCFLMRLQQ (0) 17656
17585 EKPQPNTEFNYDNLVSTVLNLYLAGTETTSSTIRYALNVLIRHPKIQ (1) 17445
17323 EKMQEDIDSVIGQGRCPYVEDRKSLPFTDAVLHEIQRYLDMIPFSIPHYALQDISFRG 17147
17145 YTIPK (0) 17131
17056 DTLIIPLLHSVLKDDKMWETPGSFNPQHFLDGNGSFKKNPAFLPFSA (1) 16916
16823 GKRACVGESLARMEIFLFVVSLVQHFTLSCPGGPDSVDLTPEYSSFANVPRKYKIIATPRWQ* 16635
CYP2Y2 Fugu rubripes (pufferfish)
No accession number
Scaffold_39b from an early version of the genome
15595 MEFSVTLILAGLVLAFFWFILQKRKYNLPPGPTTLPLVGNLPQLDKKQPFKSFTE 15431 (0)
15356 LSKSYGPVMTLYLGWQRTVVLTGYEVVKEALVDQAEDFTGRGPLPFLLKATNGY 15195 (1)
15078 GLGISNGERWRQLRRFTLSTLRDFGMGRKGMEEWIQEESKHLTARIKTLK 14944 (1)
14815 VKPFDPTFLLGCTVSNVICCMVFGERFSYDDKQFLELLRVIAEVLRFNSSFLGQ 14654 (0)
14549 MYNVFPWILEHLPGPQHTMFSHVNFLREFIKKKIQEHKESLDPSSPRDYIDTFLIRMEQ 14373 (0)
14282 EKNLPNTEFHYENLVSTVLNLFLAGTETTSSTLRYALGVLIKHPNVQ 14142 (1)
14046 EEMQREIDNVVRQDQCPKMEDRKSLPFTDAVIHEVQRFLDIVPFGLPHYALKDITFRGYSIPK 13858 (0)
13775 GTVIIPLLHSVLKGDQWETPWAFNPKHFLDQNGSFKKNSAFLPFSA 13638 (1)
13390 GKRSCVGESLARMELFIFLVTLLKDFTFSCIEGPDSISLNPQYSGFANLPRNYEIVATPR* 13208
GenEMBL CAAB01000830 WGS section of Genbank 25-JUL-2002
22434 MEFSVTLILAGLVLAFFWFILQKRKYNLPPGPTTLPLVGNLPQLDKKQPFKSFTE (0) 22270
22195 LSKSYGPVMTLYLGWQRTVVLTGYEVVKEALVDQAEDFTGRGPLPFLLKATNGY (1) 22034
21935 GLGISNGERWRQLRRFTLSTLRDFGMGRKGMEEWIQEESKHLTARIKTLK (1) 21786
21654 VKPFDPTFLLGCTVSNVICCMVFGERFSYDDKQFLELLRVIAEVLRFNSSFLGQ (0) 21493
21388 MYNVFPWILEHLPGPQHTMFSHVNFLREFIKKKIQEHKESLDPSSPRDYIDTFLIRMEQ (0) 21212
21121 EKNLPNTEFHYENLVSTVLNLFLAGTETTSSTLRYALGVLIKHPNVQ (1) 20981
20885 EEMQREIDNVVRQDQCPKMEDRKSLPFTDAVIHEVQRFLDIVPFGLPHYALKDITFRGYSIPK (0) 20697
20614 GTVIIPLLHSVLKGDQWETPWAFNPKHFLDQNGSFKKNSAFLPFSA (1) 20477
20296 GKRSCVGESLARMELFIFLVTLLKDFTFSCIEGPDSISLNPQYSGFANLPRNYEIVATPR* 20047
CYP2Y3 Danio rerio (zebrafish)
GenEMBL ESTs CK016257, CK869788, CK706387, CB891035
Zebrafish blast server May 04 sequence NA1608
62% to 2Y1 and 64% to 2Y2 45% to CYP2B6 45% to 2B3
30425 MELSSSLLLVLVLTVLMLIRWRRKENGLSLPPGPLALPLIGNLLTLDKSAPFKSFMK 30595 (0)
32151 WRKTYGSVMTVHLGPQRMVVLVGYETVKEALVDQAEDFAPRAPIAFMNRIVKGY (1?)
GLAISNGERWRQLRRFTLTTLRDFGMGRKQMEQWIQEESRYLLKSFEETK 32519 (1?)
32651 SKPVDPTFFFSRTVSNVICSLVFGQRFDYEDKNFLQLLQIISKLLRFLSSPWGQ 32812 (0?)
33063 LYNIFPQVMERFSSRHHAILKDVENIRTFIRNKVKEHEQRLDFSDPSDFIDCFLIRLTQ 33239 (0?)
33356 EKDKRKLDTEFHKDNLMATVLNLFVAGTETTSTTLRYALMLLIKHPQIQ 33502 (1?)
34553 EQMQREIDRVIGQNRIPTMEDRKSLPFTDAVIHEVQRYMDIVPLSLPHYAMKDITFRGYKIPK 34741 (0)
34907 DTVIIPMLHSVLRDEGQWETPWTFNPEHFLDSNGNFKKNPAFMPFSA 35047 (1)
35424 GKRSCVGESLARMELFLFTVSLLQKFTFSSPNGPDGIDLSPELSSFANMPRFYELIASPR* 35606
CYP2Y4 Danio rerio (zebrafish)
GenEMBL EST AL916779
Zebrafish blast server May 04 sequence NA1608
42397 MELSSSLLLVLVLTVLMLIRWRRKENGLSLPPGPLALPLIGNLLTVETSAPFKSFMK 42567 (0)
missing exon 2
XXXXTNGERWRQTERFTLTTLRDFGMGRKRMEQWIQEESRYLLKSFEETK
SKPVDPLFFMSRAVSNVICSLVFGQRFDYEDKNFLQLLQIISNLMRFASSPWGQ
LYNIFPKVMEILPGRHHTMFGEIDDLKSSIMTII 44325
44326 KEHEENLDPSDPKDFIDCFLIRLNQ (0?)
QEKHNPDT 44524 44525 EFHKENMFATSLNLFTAGTETTSTTLRYALMLLIKHPHIQ
44989 EQMQREIDCVIGQNRIPTMEDRKSLPFTDAVIHEVQRCLDIAPLNVPHYALKDITFRGYKIPK 45177 (0)
DTVIIPMLHSVLRD 45348 45349 EGHWETPWTFNPEHFLDSNGNFKKNPAFMPFSA 45447 (1)
46751 GKRVCVGESLARMEIFLFIVSLLQKFSFSSPNGPDSIDPSPELSSFGNMPRLYELIASPR 46930
CYP2Y5 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr I (-) strand 16588689-16592714
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
68% to Fugu 2Y1, 70% to 2Y2
MDFSATVFLAGLILALLWLFGVKNRRKYLLPPGPFALPLIGNLPQLDKNAPFKSILKFSETHGPVMTVHLGWQRV
VFLVGYDAVKEALVDQGDDFTGRGPLPFLMKVTKGYGLAISNGERWRQLRRFSLSTLRDFGMGRKGMEVWIQEES
RHLRARMESFKASPFNPRFLLSRTVSNVICCLVFGERFGYEDKKFLHLLNTISEVLDFLNSPVGQLYNIFPWLMG
HLPGSQHACFAKAEKLREFIETKIHQHKATLDPSSPRDFIDCFLIRINQEKDNPKTEFHYENLISTVLNLFLAGT
ETTSSTIRFALSVLIKYPNIQEKMQTEIDGVIGQSCVPSMENRKSLPFTDAVIHEVQRFLDIVPFSIPHYALHDI
SFRGYTIPKDTMIIPMLHSVLKEERNWATPQSFNPQHFLDQNDNFKKNPSFLPFSAGKRACVGESLARMELFIFL
VSLLQNFTFSSTGGPDSINLIPEYSSFANLPRTYQIIATPR*
CYP2Y6 Oryzias latipes (medaka)
chr 13 2357422:2368485
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
68% to Fugu 2Y1
MDLSTSLILVVLTTVLLWLLNRRNSRKQHLPPGPPALPLIGNLLQLDKKRPFRTIVELSKTHGPVMTIYMGWQRA
VALVGYDAVKEALVDQADDFVGRAPLPFLYRATRGYGIGISNGERWRQLRRFALTTLRDFGMGRKGMEQWIQEES
RHIRAKINTFKGKPFDPTFILSCTVSNVICCLVYGERFNYDDKQFLELLQIISEVPRFNSSPMGAMYNLFPWLME
RLPGRQHTIFGYIEDIRKFAKNKIQEHKDKLDPSSPRDFIDCFLLRMDQEKDNPTSEFHYENLLAMVLNLFLAGT
ETTSSTIRYALSVLIKHPKIQEKMQEEIDSVIGRERCPSMEERKSLPFTDAVIHEVQRFMDLTPFSLPHYSLKDI
SFRGYTIPKDTMIFPMLHSVLREDKLWSSPWSFNPQNFLDQNGNFKKNPGFVPFSAGKRACVGESLARMELFLFI
VSFLQDFTFSAPNGPDSINLVPEYSSLANLPRRYELIATPR
2Z Subfamily
CYP2Z1 Fugu rubripes (pufferfish)
No accession number
Scaffold_2993a
MGLIVSVFGSHADWSISTLLLFTAVFILMVNWIRNRRPPSFPPGPWTLPVVGNMHNLAHHRMHLNLME (0)
16293 LAETYGNVFSIQLGQEWMVVLNGPTILKEALVNQGDSVADRPNLQLIIDSCHGL (1)
16785 GLGFSSGHLWKQQRQFAISTLRYFGSGSKSLEPVVLEEFAHCAKQFSEFK 16937 (1)
17023 GKPFAPQLMFYNIVTNIICSLVFGHRFEYGDKNFEKLMNSFGRCLQIEASVCAQ 17184 (0)
17262 LYNSFPRLMGCLPGPHQTVKRIYQNIRDFIREEMKEHKKGLDPSTPRDYIDCYLNKIKK 17435 (0)
XXXXXXXXXXXNL (fs) VIX (fs) VWNX (fs) FVPX (fs) TNT (fs) TTFTYRWLFLFMA
(fs) KYPEMQ (1)
17899 EKVQAEIDEVIGQSRRATMDDCVNMPYTNAVIHESLRMGNVVPLSLLHATGRDIQLEGYTIPK 18087 (0)
18158 GTTVIANLTSALFDKNEWETPFAFNPGHFLDEEGRFRKRTAFLPFSA (1)
18388 GRRLCLGENLARMMLFLFFTSFMQDFTISFPAGVSPAMEYHHFGVTLAPHPFDICAVSR* 18567
CYP2Z2 Fugu rubripes (pufferfish)
No accession number
Scaffold_2993b
MHWIFDLIGSFLAGDFKSLLFFLLIFILTADYLRNRRSGSFPPGPMAIPIIGNMLSLDRSRTHESLTQ (0)
21437 LAETYGNVYSLRTGQTWMVVVNSFKVVREALVTHGESVSDRPDLPLQDEIAHGK 21273 (1)
20946 GVISSNGHLWKQQRRFALSTLRLFGFGKKSLEPFITDEFTHCANIFRSYK 20815 (1)
20726 GKPLPPHLILNNVVSNIICSLVFGHRFEYGDKNFKNLIKLFDQSLQIEASVWAE 20565 (0)
20473 LYNSFPLLMKHVPGPHQTVKKIWNEVKDFVRNELKEHRKNWDPSDPRDYIDCYLREIQX 20300 (?) gap at boundary
19990 SGQSDSTFDEENLVICVMDLFVPGSETTSTTLRWAFLYMAKYPEIQ (1)
19748 EKVQAEIDRVVGQSRPLTMDDRVNLPYTDAVLHEIQRFGNIVPLSLPHVTNKAIQLEGYNIPK 19560 (0)
19470 GIMIIPNLTSALFDKNEWETPCTFNPGHFLDNEGKFRKRAAFIPFSA 19330 (1)
19220 GKRLCLGENLARMELFLFFTSFMQHFTFSMPAGVKPDMSFRFGVTLAPKPYEICAIPR* 19044
CYP2Z3 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr VIII (-) strand 15162832-15165857
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
51% to Fugu 2N9, 71% to CYP2Z2 probable ortholog of CYP2Z2
MDSIFSICGSYFTLDVKSFLLFAVVFLLSADYIKNRRPGSFPPGPPALPIVGHIFNLDYKRVHVSLTQ
LAGRYGDVYSLRMGHRWMVVLNGITVLKEALVTQGDSLADRPDLPLQHDIAHGL
GVIFSNGNTWKQQRRFALSALRHFGFGK
KSLEPVILDEFTYCVKDFNSHKGKPFDPHLIVNNVVSNVICSLVFGHRFEYGDEKFLKLMKWFGDALELEASIWA
QLYNSFPVLMRRLPGPHKDLQHIWNNVKDFIGVELKEHKQNWDPSDQRDYIDCYLNEIQTGQADNTFDEENLVLC
VLDLFLAGSETTSTTLRWAFLYMVKYPEIQAKVQAEIDRVIGQSRLPSMEDRANMPYTDAVIHEVQRMANIVPLS
LPHITSKDIQLGGYTIPKGVTIIPNLTSVLFDKNEWETPDTFNPGHFLNAEGKFVKSAAFIPFSAGKRLCLGENL
AKMELFLFFTSFMQRFTFSMPPGVKPVMDFRFGITLAPFPYEVCVTSR*
CYP2Z4 Gasterosteus aculeatus (three-spined stickleback)
UCSC browser Chr VIII (-) strand 15162832-15165857
Joanna Wilson and students
submitted to nomenclature committee Nov. 6, 2007
missing exon found in ESTs DN671369.1, DW642948.1
revised seq 59% to 2Z2
MDQLSGVSSTWLWLDGRSLLLFTLVVLVTAEYLRARRPSGFPPGPWPFPLVGNMFSLDPSNVHGDMTK (0)
LAEKYGKVYSLKMGPLWSVVLNGLSAVQEGLAEGDYANGRPDFAIHSDVLPEL (1)
GIVFSNGH
SWKQQRRFALITLKYFGVGKKSLESSILEEFIHASKEIASHEGKPFKPNVLMRNAVSNIICALVFGHRFEYSNEK
FQKMLTLLDNGTRIEASIWAQMYNAFPVLMRRLPGPHRTLQGIYGEILDLIKTEVDQHREDFNPSEPRDFIDCYL
NEMEKVADAGFNEDNLLMCSFDLFGAGTETTSTTLLWAFLYMAKYPEIQAKVQAEVGRVIGPSRQPSMKDRANMP
YTDAVIHEVQRIGNIVPLSLPHITSRDVQLGGYTIPKGVTIIPNLTSVLFDKNEWETPDTFNPGHFLNEEGKFVK
PAAFIPFSAGRLCLGENLARMELFLFFSSFMQRFSWSMPAGVEPLLKPRFGITLSPEPYEICAISR*
CYP2Z5 Oryzias latipes (medaka)
chr4 31513782:31524077
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
70% to Fugu 2Z2
MDLFSSTIGLMLEWDLKSLLLFLSVFIITADYIKNRRPLSFPPGPPGLPILGNIFTVDVGRPHESFSKLAAEYGD
LYSLRFGQRWTVVLNGHKALKEALVTKGDSVVDRPHLPLQDEIAKGLGVIFSNGANWTEQRRFALSTLRYFGFGK
KSLEPVILNEFAHCAEELKRFKGEPLDPHLIINNTVSNIICHLVFGHRFNYGDKKFKKLMLLFDRALQIEASIWA
QLYNSFTLIMRCLPGPHKTLQHIWREVQDFIGEELKEHKKSWDPSDARDYIDFYLTEIQKTKGQEGSTFDEENLI
MCVLDLFVAGSETTSTTLRWAFLYMAKYPEIQEKVQAEIHKVIGKSRPPCMEDRAELPYTDAVIHEVQRIGNIVP
LSLPHATNKDVQLGGFTIPKGVLIIPNLTSVLFDEKEWETPHAFNPGHFLNKDGKFVKRGAFIPFSAGKRLCLGE
NLARMELFLFFTSFMQHFSFSMPAGVEPVLDYRAGLTLAPKPYKICVQASSEK*
2AA Subfamily
CYP2AA1 Danio rerio (zebrafish)
GenEMBL AF497969
Afonso Bainy and John Stegeman
74% to 2AA2
submitted to nomenclature committee 4/5/02
MLVGLVKLDLASVGLTLFLGLIFLVLFEIFRINSYKFRFPPGPT
PLPFVGNLPHFLKSPMEFIRSMPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQDAFSG
RPAIPLFDWITNGLGIVMVTFNNSWRQQRRFALHTLRNFGLGKKTVEDRVLEESRYLI
AEMLKEEGKSMNPQHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNENIMLAGSA
AGQIFNLVPFIKHFPGPHQKIKQNADELLGFIRDEAKEHKQTLDPDSPRDFIDAYLLE
IEKQKSSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIV
RVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTRLHGYDIPQGTII
LTNLAAIFSNKDHWKHPDAFNPENFLDENGHFSKPESFIPFSLGPRVCLGETLARTEL
FLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNVVCHSRDNVK
CYP2AA1 Danio rerio (zebrafish)
Chr 23
2AA1 partial seq missing exons 7-9 (broken gen may indicate incorrect genome assembly here)
1 66 + Chr:23 38951974 38952171 - 345 2AA1 2 diffs
211044 MLVGLVKLDLASVGLTLFLGLIFLVLFEIFRIHSYKGRFPPGPTPLPFVGNLPHFLKSPMEFIRS 210850
62 117 + Chr:23 38949574 38949741 - 453 2AA1 1 diff
208602 MPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQDVFSGRPAIPLFDWITNGL 208450
116 214 + Chr:23 38945155 38945454 - 439 2AA1 1 diff
204324 GIVMVTFNNSWRQQRRFALHTLRNFGLGKKTVEDRVLEESRHLIAEMLKEE 204172
168 268 + Chr:23 38944809 38945129 - 471 2AA1 100%
204002 GKSMNPQHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNENIMLAGSAAGQ 203841
222 395 + Chr:23 38944376 38944861 - 529 2AA1 100%
203734 IFNLVPFIKHFPGPHQKIKQNADELLGFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK 203561
Chr:23 38944462 38944602 - 2AA1 1 diff
203475 QKPSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQ 203335
3 exon fragment exons 7,8,9 2AA1 like sequence. This gene is broken by an insertion of 2AA8 exons 1-8
I think the 2AA8 sequence needs to be moved to reunite 2AA1 fragments and make a whole 2AA1 and
A whole 2AA8
318 388 + Chr:23 38934350 38934556 - 550 2AA1 2 diffs
ERCHEEIVRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTKLHGYNIPQ 193223
359 440 + Chr:23 38931225 38931455 - 446 2AA1 1 diff
GTIILTNLAAIFSNKEHWKHPDAFNPENFLDENGHFSKPESFIPFSL 190116
436 498 + Chr:23 38927597 38927785 - 549 2AA1 100%
186658 GPRVCLGETLARTELFLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNVVCHSRDNVK 186470
8 aa diffs to original Stegeman sequence AF497969, 3kb upstream of 2AA10
211044 MLVGLVKLDLASVGLTLFLGLIFLVLFEIFRIHSYKGRFPPGPTPLPFVGNLPHFLKSPMEFIRS 210850
208602 MPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQDVFSGRPAIPLFDWITNGL 208450
204324 GIVMVTFNNSWRQQRRFALHTLRNFGLGKKTVEDRVLEESRHLIAEMLKEE 204172
204002 GKSMNPQHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNENIMLAGSAAGQ 203841
203734 IFNLVPFIKHFPGPHQKIKQNADELLGFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK 203561
203475 QKPSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQ 203335
ERCHEEIVRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTKLHGYNIPQ 193223
GTIILTNLAAIFSNKEHWKHPDAFNPENFLDENGHFSKPESFIPFSL 190116
186658 GPRVCLGETLARTELFLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNVVCHSRDNVK 186470
CYP2AA2 Danio rerio (zebrafish)
AI657973 fc19c11.y1, AI958603 fc94a10.y1, AI544967 fb69h12.y1
BI887677 AI444248 fb40e01.y1
zfishC-a1385b03.q1c zfishC-a2172h09.q1c zfishG-a67c10.q1c
these last three are from the zebrafish blast server
48% to 2J1 74% to CYP2AA1
intron phases from closely related zebrafish genomic sequences
MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL (0) exon 1
MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPAIDWTSNGC (1) exon 2
GIIMATFNNSWKQQRRFALHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE (1) exon 3
GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ (0) exon 4
IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK (0) exon 5
QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ (1) exon 6
ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ (0) exon 7
GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV (1) exon 8
GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFSIICCSRDTKE* exon 9
CYP2AA3v1 Danio rerio (zebrafish)
BC055136 ctg14330 Zv3 05/2004 zfishC-a1177h12.q1c Z35723-a631b05.p1c
zfishI-a76h10.q1c
131529 MFTALLKLDLASVGLTLFLGLIILVLFEIFRIHSYKRRTPPGPTPLPFVGTIPHFLKNPLGFIR 131720
131812 MSQYGDMSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGFG 131967
132158 GIAMVTFNHSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEM
LKDEGKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRFEYLLKMLNETIMLAGSASGR
IFNLVPFIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTLDPGSPRDFIDAYLLEIEK
QKFNKDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLLLIQNPDVQERCHEEIVRVL
GYDRLPSMNDRDRLPYTLATVHEIQRYGNIIPILIHETILPTKLQGYSIPQGTTIVTN
IQAIFSSKDHWKHPDTFNPENFLEDGHFIKPESFIMFSLGPRSCLGEMLARTELFLFI
TSLLQRIHFSWPPDAKPIDMDGIFGLVHSPQTFNVICRSRDTK
CYP2AA3v1 Danio rerio (zebrafish)
GenEMBL AL923007
Tseng, H.-P., Wang-Buhler, J.-L., Hu, C.-H.,
Hseu, T.-H., Peng, J.R. and Buhler, D.R.
Submitted to nomenclature committee Oct. 14, 2004
JR12
Note: multiple ESTs and mRNAs support both 2AA3v1 and 2AA3v2
Even though they only have 6-8 aa differences
CYP2AA3v2 Danio rerio (zebrafish)
GenEMBl CK698285.1 EST and UCSC genomic seq.
CYP2AA3v2 Danio rerio (zebrafish)
ctg14330 (7 aa diffs in the last four exons to 2AA3v1)
131529 MFTALLKLDLASVGLTLFLGLIILVLFEIFRIHSYKRRTPPGPTPLPFVGTIPHFLKNPLGFIRS 131723(0)
131812 MSQYGDMSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGF 131964 (1)
132158 GIAMVTFNHSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEMLKDE
133974 GKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRFEYLLKMLNETIMLAGSASGR 134135 (0)
136328 IFNLVPFIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTLDPGSPRDFIDAYLLEIEK 136501 (0)
136597 QKFNKDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQ 136739 (1)
ERCHEEIVQVLGYDRLPSMDDRDRLPYTLATVHEIQRYGNIIPILIHETILPTKLQGYSIPQ 140163 (0)
143088 GTTIVTNIQAIFSSKDHWKHPDSFNPENFLEDRHFIKPESFIMFSL 143225 (1)
143308 GPRSCLGEILARTELFLFITSLLQRIHFSWPPDAKPIDMDGIFGLVHSPQAFNVICRSRDTK 143493
CYP2AA4 Danio rerio (zebrafish)
ctg14330 77% to 2AA1 missing exons 1,2 dup exons 3,8
zfishB-a33e04.q1c zfishB-a46b05.q1c zfishC-a2901c10.p1c zfishK-a149h03.q1c
AI266900 (exons 1,2,3)
This is an older version of the sequence, use the newer version below
MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL
MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVIDWTSNGC
716 GIIMATFNNSWKQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDE 868
1337 GKSMNPQHALQNAVSNIICSIVFGERFDYDNKRLGYLLKILNENMMLTGSAIGQ 1498
4286 IFNLAPFIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTLDPVSPRDFIDAYLLEIEK 4459
QKSNKDSTFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQ 4684
5758 ERCHEEIVQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQ 5946
6575 GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSL 6715
8861 GLRACIGESLVRTELFLFATVLLQRIHFSWPPNAKPIDMDGIMGLVHSPQTFNVICRSRDTK 9046
CYP2AA4-ie3 Danio rerio (zebrafish)
ctg14330 dup exon 3
1089 QRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDEG
CYP2AA4-ie8 Danio rerio (zebrafish)
ctg14330 dup exon 8
6375 GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESY 6500
CYP2AA4 Danio rerio (zebrafish)
Chr 23
96% exons 4,9 do not match older version of 2AA4 above
CK697338.1 only has three diffs in exon 4 to this seq
EB851360.1 matches exon 3 and exon 4 to YDNK 100%
EB982730.1 matches exon 4 and part of exon 5 with 1 diff near the end
There is EST support for this exon 4 in context.
No ESTs match the old exons 4 or 9
No exact match for the old exons 4 or 9 is found in the new assembly
275732 GEPVNPHHALQNAVSNIFCSIMFGERFDYDNKRLGYLLKILNENMMLTGSAIGQ 275571
278301 MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL 278107
278025 MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVIDWTSNGC 277873
276540 GIIMATFNNSWKQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDE 276388
GEPVNPHHALQNAVSNIFCSIMFGERFDYDNKRLGYLLKILNENMMLTGSAIGQ 275571
272893 IFNLAPFIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTLDPVSPRDFIDAYLLEIEK 272720
272635 QKSNKDSTFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQ 272495
271423 ERCHEEIVQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQ 271235
270806 GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSL 270666
268511 GLRACIGESLVRTELFLFATVLLQRIHFSWPPDAKPLDMDGIVGIVRYPQTFSIICCSRDSKK 268323
Chr:23 39019324 39019347 - 2AA4 100%
278301 MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGF 278116
62 117 + Chr:23 39018997 39019164 - 315 2AA4 100%
278025 MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVIDWTSNGC 277873
116 168 + Chr:23 39017512 39017670 - 375 2AA4 100%
276540 GIIMATFNNSWKQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDE 276388
55 222 + Chr:23 39016695 39017207 - 347 zfishB-a496h01.q1c 100%
GEPVNPHHALQNAVSNIFCSIMFGERFDYDNKRLGYLLKILNENMMLTGSAIGQ 275571
222 292 + Chr:23 39013805 39014020 - 422 2AA4 100%
272893 IFNLAPFIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTLDPVSPRDFIDAYLLEIEK 272720
273 326 + Chr:23 39013622 39013774 - 305 2AA4 100%
272635 QKSNKDSTFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQ 272495
327 388 + Chr:23 39012362 39012550 - 394 2AA4 100%
271423 ERCHEEIVQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQ 271235
388 440 + Chr:23 39011775 39011936 - 406 2AA.e 100%
270806 GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSL 270666
433 498 + Chr:23 39009450 39009644 - 408 new 84% to 2AA4
268511 GLRACIGESLVRTELFLFATVLLQRIHFSWPPDAKPLDMDGIVGIVRYPQTFSIICCSRDSKK 268323
Chr:23 39003564 39003746 - 2AA5 exon 9 2 aa diffs 5.7kb downstream
262622 GPRSCLGETLAKTELFLFITSLLQRIRFSWLPDAKPLDMDGIMGIVRYPQPFSIICCSRDTK 262437
CYP2AA5X Danio rerio (zebrafish)
ctg14330 90% to 2AA2
This sequence discontinued since it is probably an incorrect
assembly of 2AA9
77910 MFTALLKLDLAFVGLTLFLGLIFLVVFEISRIYSYKCRFPPGPTPLPFVGNLPHLLKKPMEFIRX 78101
78196 LSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAGRPHLPIIEWITKGL 78348
78622 GIVMVTFNHSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE 78774
78980 GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ 79141
IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK
81107 QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ 81249
85877 ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ 86065
86197 GTIIMTNLAAILSDKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGVG 86340
95083 PRSCLGETLAKTELFLFITSLLQRIRFSWLPDAKPLYMDGIMGIVRYPQPFIIICCSRDTK 95265
CYP2AA6 Danio rerio (zebrafish)
NA16005 Exons 4-7, 9 fd54c03.y1 AW019538 = fd54c03.x1 AI658337
fc21h01.y1 fc21h01.x1 CA473712 73% to 2AA1
MLAALLKLDLSSVGLSLFLGLIFLVLFEIFRIHSCKGRFPPGPTPLPFVGSIPHFLNNPMGFIKS
LSQYGEMTTVYPGRKPAIILNTLQLMKEALVQNGSSFSGRPPVPVFNWVTDGY
GIVMATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISEFLKAE
4444 GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENIIQAGSLVGQ 4605 (0)
7506 VFNLVPIIKHVPGPHQKIYQNGQAFKSFIRESVKEHRQTLDPDSPRDFIDAYLLEMEK 7679
7891 QKSTQDSTFHEDNMVMAVGDLFLAGSDTTATTIRWGLIYLTQNPDVQ 8031
10145 ERCHEEIVRVLGFDRLPSMDDRDRLPYTLATVHEFQRCANLVPTGVPHETTQATKLRGYDIPQ 10334
10407 GTQILINLTEILTNKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL 10547
GPRACLGETLAKAELFLFVTSLLQRIRFSWPTGEKLPDMNGIFGIVRSPKPFNIICHSRGSKH* 10813
CYP2AA6-ie6 Danio rerio (zebrafish)
NA16005 Duplicate exon 6 (3 aa diffs)
9660 QKSTQDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQ 9800
CYP2AA6
Chr:23 39065253 39065285 -
324158 MLAALLKLDLSSVGLSLFLGLIFLVLFEIFRIHSCKGRFPPGPTPLPFVGSIPHFLNNPMGFIKS 324045
62 148 + Chr:23 39064791 39065066 - 308 2AA6 100%
323927 LSQYGEMTTVYPGRKPAIILNTLQLMKEALVQNGSSFSGRPPVPVFNWVTDGY 323769
52 168 + Chr:23 39062897 39063256 - 349 2AA6 100%
GIVMATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISEFLKAE 321773
168 222 + Chr:23 39056644 39056808 - 320 2AA6 100%
315681 GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENIIQAGSLVGQ 315520
221 279 + Chr:23 39053573 39053749 - 389 2AA6 100%
312619 VFNLVPIIKHVPGPHQKIYQNGQAFKSFIRESVKEHRQTLDPDSPRDFIDAYLLEMEK 312446
266 326 + Chr:23 39053221 39053439 - 322 2AA6 100%
QKSTQDSTFHEDNMVMAVGDLFLAGSDTTATTIRWGLIYLTQNPDVQ 312094
325 431 + Chr:23 39051558 39051914 - 321 2AA6 1 diff
310781 ERCHEEIVRVLGFDRLPSMDDRDRLPYTHATVHEFQRCANL
389 459 + Chr:23 39051431 39051646 - 342 2AA6 100%
310519 GTQILINLTEILTNKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL 310379
433 494 + Chr:23 39051255 39051440 - 390 2AA6 100%
310304 GPRACLGETLAKAELFLFVTSLLQRIRFSWPTGEKLPDMNGIFGIVRSPKPFNIICHSR 310128
CYP2AA7 Danio rerio (zebrafish)
NA16005 Exons 1-7 83% to 2AA1 96% (6 diffs) to AI964243 EST269357 zfishG-a606c02.p1c
AI964243 probably = AI964242 and BQ605503
17072 MFAALLKLDLASVGLTLFLGLIFLVLFEIFRINSYKGRFPPGPTPLPFVGNLPHSLKNPMEFIRS 17266
17365 MPQYGEMTTMYLGRRPAIVLNTIQLAKEAFVQDAFSGRPFLPVMDWVANGL 17517
17817 GIIMVTFNHSWRQQRRFALHTLRNFGLGKKSVEDRVLEESRYLIAEILKGE 17969
19246 GKPMSPHHPIQNAVSNIICSIVFGDRFDYDNKRFEYLLELLNENFVLTGSAAGQ 19407
19622 IFNLAPFIKHFPGPHQKIKQNANELLAFIQGEVKEHKKTLDPDSPRDFIDAYLLEIEK 19795
QKSNKDSTFHEGNLAISTADLFLAGTDTTSTTIRWGLLFLTQNPDVQ 20038
20933 ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRCANLVPFGVIHETIQPTKLRGYDIPQ 21121
GTVVMTNLAAILSDKEHWKHPDTFNPENFLDENGHFSKPESFIPFSL
GPRFCLGETLAKMELFLFITSLLQRIRFSSPPDAKPIDMDGIMGIVRYPQPFSIICCSRDTKE*
1 66 + Chr:23 39045108 39045305 - 304 2AA7 100%
304178 MFAALLKLDLASVGLTLFLGLIFLVLFEIFRINSYKGRFPPGPTPLPFVGNLPHSLKNPMEFIRS 303984
62 117 + Chr:23 39044857 39045024 - 373 2AA7 100%
303885 MPQYGEMTTMYLGRRPAIVLNTIQLAKEAFVQDAFSGRPFLPVMDWVANGL 303733
117 168 + Chr:23 39044405 39044560 - 398 2AA7 100%
303433 GIIMVTFNHSWRQQRRFALHTLRNFGLGKKSVEDRVLEESRYLIAEILKGE 303281
168 232 + Chr:23 39042937 39043131 - 374 2AA7 100%
302004 GKPMSPHHPIQNAVSNIICSIVFGDRFDYDNKRFEYLLELLNENFVLTGSAAGQ 301843
197 289 + Chr:23 39042555 39042800 - 468 2AA7 100%
IFNLAPFIKHFPGPHQKIKQNANELLAFIQGEVKEHKKTLDPDSPRDFIDAYLLEIEK 301455
277 326 + Chr:23 39042339 39042488 - 316 2AA7 100%
301352 QKSNKDSTFHEGNLAISTADLFLAGTDTTSTTIRWGLLFLTQNPDVQ 301212
327 388 + Chr:23 39041256 39041444 - 461 2AA7 100%
300317 ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRCANLVPFGVIHETIQPTKLRGYDIPQ 300129
388 440 + Chr:23 39039665 39039826 - 384 2AA6 like 2 diffs
298696 GTVVMTNLAAILSDKEHWKHPDTFNPENFLDKNGQFSKPESFIPFSL 298556
last exon is missing in genome assembly, use EST seq
CYP2AA8 Danio rerio (zebrafish)
NA3313 78% to 2AA7 zfishC-a402h10.p1c zfishC-a440h04.p1c
Chr 23 (probably an assembly error, since this gene breaks 2AA1 in half)
540 MFSALLKLDLAFAGMTLILSLIFMFLLEIFRIHSFKSRFPPGPSPLPFVGNLPVFLKNPMEFIRS 734
811 LSQYGEMTTIYLGRKPTIMLNTVQLAKEVLIQDAFAGKPSLPVLDWVSNGL 963
1198 GIVMVTFNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKK 1350
1544 GKSVNPHHALQNAFSNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQ 1705
3903 IFNFAPIIKHFPGPHQKIKKNADELSGFFQHEVKEHKKTLDPGSPRDYIDAYLLEMEK 4076
QKSNKDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQ 4304
4703 ERCHKEIVQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPR 4891
GTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSL 5173
8867 GVRVCLGETLARTELFLFITALLQRIRFSLPPDAKPMDMDGILSVLRYPQNFSFICCSRDTKE 9055
CYP2AA9v1 Danio rerio (zebrafish)
GenEMBL AY825258, AL922288 ESTs AI544967.1, CK708594.1
EST BI887677 matches 2AA2 with 1 diff and 2AA9 with 2 diffs
Tseng, H.-P., Wang-Buhler, J.-L., Hu, C.-H.,
Hseu, T.-H., Peng, J.R. and Buhler, D.R.
Submitted to nomenclature committee Oct. 14, 2004
JR11
94% to 2AA5
MFTALLKVDLASVGLTLFLGLIFLVVFEIFRIYSYKCRFPPGPT
PLPFVGNLPHLLKKPMEFIRSLSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAG
RPHLPIIEWITKGLGIVMVTFNNSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLI
AEMLKDEGRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSA
AGQIFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLE
IEKQKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIV
QVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETAQPTKLRGYNIPQGTI
IMTNYTAIFSNKEHWKHPDTFNPENFLDENGHFSKPKCFIAFGVGPRICLGDTLAKTA
LFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFCIICCSRDTKE
CYP2AA9v2 Danio rerio (zebrafish)
Chr 23
98% (7 diffs) to 2AA9v1 possible haplotype seq
Note 2AA2 has only 3 aa diffs with 2AA9v2 from aa 122 to aa 499. Only 1 diff in exons 4-9.
There are 4 aa diffs to 2AA9v1 in same region
However, ESTs EB965911.1 and CF416995.1 match 2AA2 seq over the first 200 aa
EB965911.1 100% and CF416995.1 3 aa diffs so 2AA1 is supported
As distinct from 2AA9
2AA9v2 is 100% to 2AA5 in exons 1-7 but differs in exons 8,9
no ESTs match CYP2AA5 exons 8,9. Genomic seq for 2AA5 exon 9 is found
with 2 aa diffs at Chr:23 39003564-39003746 55kb away. This was probably an error
in an earlier assembly of contig ctg14330. in this contig exon 8 has 4 aa diffs
from 2AA9 exon 8 in a close region, possibly seq errors. I think 2AA5
may not exist but 2AA9 is the correct version of this gene.
231378 MFTALLKLDLAFVGLTLFLGLIFLVVFEISRIYSYKCRFPPGPTPLPFVGNLPHLLKKPMEFIRS 231184
231092 LSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAGRPHLPIIEWITKGL 230940
230666 GIVMVTFNHSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE 230514
230308 GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ 230147
228436 IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK 228263
228179 QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ 228039
224651 ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ 224463
224331 GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV 224191
GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFCIICCSRDxx 217157
1 66 + Chr:23 38972308 38972505 - 287 2AA5 100%
231378 MFTALLKLDLAFVGLTLFLGLIFLVVFEISRIYSYKCRFPPGPTPLPFVGNLPHLLKKPMEFIRS 231184
62 117 + Chr:23 38972064 38972231 - 312 2AA5 100%
231092 LSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAGRPHLPIIEWITKGL 230940
116 168 + Chr:23 38971638 38971796 - 379 2AA5 100%
230666 GIVMVTFNHSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE 230514
168 222 + Chr:23 38971271 38971435 - 387 2AA5 100% 2AA2 100%
230308 GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ 230147
222 295 + Chr:23 38969345 38969563 - 386 2AA5 100% 2AA2 100%
228436 IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK 228263
274 326 + Chr:23 38969166 38969324 - 304 2AA5 100% 2AA2 100%
228179 QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ 228039
327 388 + Chr:23 38965590 38965778 - 434 2AA5 100% 2AA2 100%
224651 ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ 224463
388 440 + Chr:23 38965300 38965461 - 362 2AA2 100%
224331 GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV 224191
412 495 + Chr:23 38958284 38958565 - 404 NA54442 100%, 1 AA DIFF WITH 2AA2
217336 GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFCIICCSRD 217157
Chr:23 39003564 39003746 - 2AA5 exon 9 2 aa diffs
262619 PRSCLGETLAKTELFLFITSLLQRIRFSWLPDAKPLDMDGIMGIVRYPQPFSIICCSRDTK 262437
CYP2AA10 Danio rerio (zebrafish)
Chr 23 (see below)
85% to CYP2AA1
183623 MLAALLKLDLASVGLTLFLGLIFLVLFEIFRIYSYKGRFPPGPTPLPFVGNLPHLLKNPMGFKRS
179490 LSEYGGLATVFIGRKPAISINTIQLAKEALVQDVFSGRPALPIFDWISHGL 179338
177849 GIIMVTFNHSWRQQRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDE 177697
177562 GKSMNPQHALQNAVSNIICSIVFGDRFEYDNKRFEYLLKILNENIMLTGSAAGQ 177401
176529 IYNLVPFIKHFPGPHQKIKQNADDLFNFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK 176353
176306 QKFNKDSTFHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQ 176130
174181 ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRYGNIAPKLLHETIRRTKLHGYDIPQ 173996
GTTIIANFTAMFSDKELWKHPDAFNPENFLDENGQFSKPEYFFPFSL
GPRACLGETLARTELFLFITSLLQRIRFSWPPNAKPIDMDGIVGIVRSPEPFNIICHSRDxx* 170736
1 110 + Chr:23 38924403 38924750 - 318 new 5 diffs to 2AA7
183623 MLAALLKLDLASVGLTLFLGLIFLVLFEIFRIYSYKGRFPPGPTPLPFVGNLPHLLKNPMGFKRS
62 117 + Chr:23 38920462 38920629 - 327 2AA.g 100%
179490 LSEYGGLATVFIGRKPAISINTIQLAKEALVQDVFSGRPALPIFDWISHGL 179338
116 206 + Chr:23 38918752 38918979 - 417 2AA.g 100%
177849 GIIMVTFNHSWRQQRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDE 177697
168 229 + Chr:23 38918486 38918689 - 438 2AA1 like 2 diffs
177562 GKSMNPQHALQNAVSNIICSIVFGDRFEYDNKRFEYLLKILNENIMLTGSAAGQ 177401
178 302 + Chr:23 38917411 38917794 - 507 2AA.e 100%
176529 IYNLVPFIKHFPGPHQKIKQNADDLFNFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK 176353
269 326 + Chr:23 38917257 38917439 - 363 2AA.e 100%
176306 QKFNKDSTFHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQ 176130
327 388 + Chr:23 38915123 38915308 - 451 2AA.e 4 diffs
174181 ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRYGNIAPKLLHETIRRTKLHGYDIPQ 173996
367 445 + Chr:23 38913823 38914083 - 351 2AA.f 100%
GTTIIANFTAMFSDKELWKHPDAFNPENFLDENGQFSKPEYFFPFSL
430 495 + Chr:23 38911863 38912060 - 475 new 85% to 2AA1
GPRACLGETLARTELFLFITSLLQRIRFSWPPNAKPIDMDGIVGIVRSPEPFNIICHSRD 170736
CYP2AA10-de8b9b Danio rerio (zebrafish)
Chr 23 (see below)
87% to 2AA3v1
162569 GTAIVTNFEAIFSSKDHWKHPDAFNPKNFLEDEHFSKLESFIAFSL
162346 xxRSCLGEMLVRTELFLFITSLLQRIHFSWPPDAKPIDMDGIMGLVHSPQTFNVICRSRD 162173
389 440 + Chr:23 38903541 38903696 - 321 new 80% to 2AA3
162569 GTAIVTNFEAIFSSKDHWKHPDAFNPKNFLEDEHFSKLESFIAFSL
438 495 + Chr:23 38903300 38903473 - 439 new 89% to 2AA3
162346 xxRSCLGEMLVRTELFLFITSLLQRIHFSWPPDAKPIDMDGIMGLVHSPQTFNVICRSRD 162173
CYP2AA11 Danio rerio (zebrafish)
Chr 23 (see below)
86% to CYP2AA6
293503 MLVGLLKLDLSSVGLSLFLGLFCLALFEICRIRIYKGRYPPGPTPLPFVGTIPHFLKNPMGFIRS 293309
293192 LSQYGEMTTVYLGRKPAIILNALQLMKEAFVQNGSSFSGRPPVPVLTWVNQGY 293034
289501 GIIMAMDGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISELLRVE 289349
288521 GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENLDLAGSFAGQ 288360
284034 MVNLVPIIKNLPGPHQKIYQNGEEFKSFIRESVKAHRETLDPDSPRDFIDAYLLEMEK 283861
283191 QKSTQDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQ 283051
ERCHDEIVQVLGFDCFPSMDDRDQLPYTLATVHEIQRCANVAPSGVPHQTTKPIKLRGYDIPQ 282518
282449 GTQILINLMGILANKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL 282309
GPRACLGETLAKTELFLFVTSLLQRIRFSWPTGEKWPDMNRILSVIRSPEPFNIICYSRDS 282053
1 66 + Chr:23 39034433 39034630 - 282 2AA.d 100%
293503 MLVGLLKLDLSSVGLSLFLGLFCLALFEICRIRIYKGRYPPGPTPLPFVGTIPHFLKNPMGFIRS 293309
62 138 + Chr:23 39034071 39034331 - 285 NEW 86% to 2AA6
293192 LSQYGEMTTVYLGRKPAIILNALQLMKEAFVQNGSSFSGRPPVPVLTWVNQGY 293034
117 178 + Chr:23 39030437 39030628 - 317 NA1642 100%
289501 GIIMAMDGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISELLRVE 289349
168 224 + Chr:23 39029478 39029648 - 333 NA1642 100% 5 diffs to 2AA6
288521 GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENLDLAGSFAGQ 288360
221 279 + Chr:23 39024988 39025164 - 363 new 89% to 2AA6
284034 MVNLVPIIKNLPGPHQKIYQNGEEFKSFIRESVKAHRETLDPDSPRDFIDAYLLEMEK 283861
273 326 + Chr:23 39024178 39024339 - 321 CYP2AA6-ie6 100%
283191 QKSTQDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQ 283051
312 396 + Chr:23 39023630 39023878 - 423 new 79% to 2AA6
ERCHDEIVQVLGFDCFPSMDDRDQLPYTLATVHEIQRCANVAPSGVPHQTTKPIKLRGYDIPQ 282518
388 465 + Chr:23 39023343 39023579 - 348 2AA6 3 diffs
282449 GTQILINLMGILANKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL 282309
429 496 + Chr:23 39023180 39023374 - 378 new 83% to 2AA.a
GPRACLGETLAKTELFLFVTSLLQRIRFSWPTGEKWPDMNRILSVIRSPEPFNIICYSRDS 282053
CYP2AA12 Danio rerio (zebrafish)
Chr 23 (see below)
83% to 2AA6
358763 MFASLLKLDLASVGLTLFLGLIFLVVFEIFRIRSYSGRFPPGPTPLPFVGTIPHFLKDSMGFIRS 358569 84% to 2AA7
358463 LSQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNGTSSSGRPSIPILTWITEGY 358305
GIVLATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLVPEMLKLE 353402
353113 GKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRFEYLLEIIKENINQAGSLIGQ 352952
352042 VFNLIPIIKHFPGPHQKIYQNAEELKSFIRESTKSHRETLDPDSPRDFIDAYLLEMEK 351869
351605 QKSSQDSSFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQ 351465
335727 ERCHEEIVRVLGYDRLPCMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDIPQ 335539
335464 GTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFLPFSL 335324
GPRVCLGETLAKTELFLFITSLLQRIRFSWPTGEKWPNMDGIVSVVRSPEPFKIICHSR 335067
Chr:23 39099777 39099809 -
358763 MFASLLKLDLASVGLTLFLGLIFLVVFEIFRIRSYSGRFPPGPTPLPFVGTIPHFLKDSMGFIRS 358569 84% to 2AA7
62 117 + Chr:23 39099429 39099602 - 274 2AA.d 100%
358463 LSQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNGTSSSGRPSIPILTWITEGY 358305
100 174 + Chr:23 39094517 39094729 - 346 2AA.d 1 diff
GIVLATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLVPEMLKLE 353402
167 233 + Chr:23 39094031 39094243 - 355 2AA.d 100%
353113 GKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRFEYLLEIIKENINQAGSLIGQ 352952
221 293 + Chr:23 39092960 39093172 - 421 2AA.d 100%
352042 VFNLIPIIKHFPGPHQKIYQNAEELKSFIRESTKSHRETLDPDSPRDFIDAYLLEMEK 351869
270 326 + Chr:23 39092592 39092762 - 325 2AA.d 100%
351605 QKSSQDSSFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQ 351465
324 388 + Chr:23 39076666 39076866 - 431 2AA.a 100%
335727 ERCHEEIVRVLGYDRLPCMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDIPQ 335539
389 486 + Chr:23 39076256 39076591 - 327 2AA.a 100%
335464 GTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFLPFSL 335324
429 494 + Chr:23 39076194 39076382 - 390 2AA.a 100%
GPRVCLGETLAKTELFLFITSLLQRIRFSWPTGEKWPNMDGIVSVVRSPEPFKIICHSR 335067
Chr:23 38974638 38974682 -
233555 QTFSIICCSRNTKE* 233511 (pseudogene piece after the gene)
2AB Subfamily
CYP2AB1P human
GenEMBL NT_022676.10|Hs3_22832 also AC068644.15
chr3q27.1 185030751-185015757 - strand build 33
old name = 2D31P
NT_005962.297 (genescan predicted protein has errors)
75% to 2ab1 mouse which is a functional gene
MLSLLSGLALLAISFLLLKLGTFCWDRSCLPPGPLPFPILGNLWQLCFQLHPETLLQ
LAQSVFTVWVGPIPVAVLSGFQVVKEALVSNSEQFSGRSLTPLFQDLFGER
GIICSSGHTWRQKRRFCLVMI*GLGL
GKLALEVQLQKEAAELAEAFRQEQGRPFDPQVSIVRST
VRVIGALVFGHHFLLEDPIFQELTQAIDFGLAFVSTVWRRLYDVFPWALC
HLPGPHQEIFRYQEVVLSLIHQEITRHKLRAPEAPRDFISCYLAQISK
AMDDPVSTFNQENLV*VVIDLFLGGTDTTATTLCWALIHMIQHGAVQG
TVQLELDEVLGAAPVVCYEDRKRLPYTX
AVLHDVQRLSSVMAMGAVRQCVTSTRVCSYPVSK
GTIILPNLASVLYDPECWETPRQFNPGHFSDKDGNFVANEAFLPFSAGHRVYPAD
QLAQMELFLMFATLLRTFRFQLPEGSPGLKLEYIFGGTWQPQPQEICAVPR
CYP2AB1P Bos taurus (cow)
See cattle page for details
MCPLLIWLGLLAASFLLLKFSIIYWERNHLPPDPFPFPILGNPWQLSFQLHPATLLQ
LAQTHGHVFTVWVGPTPVVVLCSFQA
KEALVSHSEQLSGWPLTPLFQDLAGERG
GVICSSGRTRRQ*RRFCLAALQGLG*GPLALELRLQEEAAGLVEAFHWEQ
GGPFDPQAPIVRSTARVTGALVFGRHFLSEDPFFQELI*ATNFGLAFXXXXXX
QLNDLFPWAFRCLPGPYREMFRYQKAVRGYIHREIMRHKLRTSEAPKDFISCYLAQIIK
ATDDPVSTFNEENLIQVVVGLFLGGTDTTGTTLYWVLIYMIQYGAIQS
ERVQQELVTVLGTSGAICYKDHEQLPHICTLLHEAQRLSSVA*V
AVCQCVTSTHVHGHPVPK
GTIILPNLAAVLCDPECWRTSRQFNPGHFLDKDGNFVVRDIFPPFSA
GHQMCLGD*LAQMKLLLMFATLLGTFSFQLPGRSPGLRLEYNFGGTRKPLPQKIYAVSRLNCPHPGPREEVL*
CYP2AB1P Canis familiaris (dog)
AACN010195735.1
exons 8,9 75% to cyp2ab1 mouse
KRELPPGSFPFPSENPWQLSFQLYPETL (N-term fragment)
1543 GTIILPNLASVLLDPECWETPQQFNPGLFLDMGGNFLVNEAFLPFSA 1683
GHQVGPGDHLALMELFLMFANPFRTFWFQLPEGSLG*DLQYIWGTL*PQPQKICAVP 1941
CYP2AB1 Monodelphis domestica (short-tailed opossum)
XM_001374342
Added N-term and removed some C-term seq
and internal seq from the prediction
61% to CYP2AB1P human
MFSLATGLAILATSFLLLR
MLAFFLARTQFPPGPCPLPILGNLLQLLSPGACYPTLLPLTRKY
GSIFTVWLGSTPVVVLNGFQAVKDALVTHSEDFADRPVTPLFEDLFGDKGIISTSGHA
WQQQRRFGLITLRALGMGKKVLEQRLQEEAQYLVEIFHRQNGTSFDPHVPIVRAAANV
ICALVFGHRFPHGDPFFQELMKAIDFGLAFVNTIWRR (0)
LYDAFPW
LLRQLPGPHRKIFRYQEIVKSLICQEIERHKQRVPEDLEDFISCYLAQITKRKDDPAS
TFDEENLIQVIIDLFLGGTETTATTLRWALLYMIHHRDVQGKVQQELDTVLGPSRVIS
FKDRKLLPYTNAVLHEVQRFCSVISVGAVRKCGTATTVQGFPIQKGTIVLPNLASVLC
DPEHWETPWQFNPGHFLDGEGNFVIHEAFLPFSAGHRVCLGELLAKVELFLVFAHLLR
EFRLRAPAGASTNERDYILWGTKQPRPYDICASPRLGRFQGGPRKDRLEAAEMQREGG
TDQ*
Cyp2ab1 mouse
GenEMBL NW_000107.1
39% to Cyp2j5 new subfamily in Cyp2 EST BY749683.1
B6-derived CD11 +ve dendritic cells, rat ortholog XM_221297.1 91%
NW_000107.1|Mm16_WIFeb01_286
MFSLFSGMAFLAGSCLLLKLATLCWRRSHLPPGPFPFPLLGNLWQLNFQLHPNMLFQ
LAQTHGSVFTVWLGSTPIVVLSGFRAVKEALVSNSEQFSGRPLTPFFRDLFGEKG
VICSNGLTWRQQRRFCLTTLRELGLGKQALEVQLQHEAAELAKVFLQEEGRA
FDPQIPIIRSTTRVIGTLVFGHHFLSEEPIFLELIQAINLGLAFASTIWRR
LYDMFPWALRHLSGPHQKIFQYHEAVRGFIRHEIIRHKLRTAEAPKDFINCYLSQITK
AIDDPVSTFSEENLIQVVIDLFLGGTDTTATTLHWALIYLVHHRAIQG
RVQQELDEMLGAAQTICYEDRERLPYTRAVLHEVQRLSSVVAVGAVRQCVTSTWMHGYYVPK
GTIILPNLASVLYDPECWESPHQFNPGHFLDKDGNFVANEAFLPFSA
GHRVCPGEQLARMELFLMFATLLRTFQFQLPEGSQDLGLEYVFGGTLQPQPQKICAVLR
CYP2AB1 rat
XM_221297 N-terminal incorrect, AC107471.6 N-term
92% to mouse
189790 MFSLFGGMAFLAGSFLLLKLAALCWRRSHLPPGPFPFPLLGNLWQLNFRLHPNMLFQ (0) 189620
LAQTHGNVFTVWLGSTPIVVLNGFRAVKEALVSNSEQFSGRPLTPFFRD
LFGEKGVICSNGLTWRQQRRFCLTTLRELGLGKQALELQLQHEAAELAEVFHQEQGRA
FDPQVPIIRSTTRVIGALVFGHHFLSEEPIFLELIRAINLGLAFASTTWRRLYDMFPW
ALRYLSGPHQKIFQYHEAVRGFIHHEIIRHKLRTPEAPKDFISCYLSQITKAMDDPVS
TFSEENLIQVVIDLFLGGTDTTATTLHWAIIYLVHHRAIQERVQQELDEVLGTAQAVC
YEDRERLPYTRAVLHEVQRLSSVVAVGAVRQCVTPTWMHGYYVSKGTIILPNLASVLC
DPECWETPHQFNPGHFLDKDGDFVTNEAFLPFSAGHRVCPGEQLARMELFLMFATLLR
TFRFQLPEGSQGLRLEYVFGGTLQPQPQKICAVPRLSSLSPREP
CYP2AB1 Gallus gallus (chicken)
chr9:15,039,303-15,044,379 (+)
49% to human 2AB1P, 51% to mouse, 54% to Xenopus
This seq is named 2AB1 since it is the most like the
single Xenopus sequence.
18744 MLGIVELFVALVASLLILQFLKLQWMRSQLPPGPVPLPIIGNLWLLDFKLRRETLAK 18914
19663 LTNIYGNIYTVWMGQTPVVVLNGYKAVKDAIVTHSEETSGRPLTPFYRDMMGEK 19824
19958 GIFLTSGHTWKQQRRFGMTIIRSLGFGKNNLEHQIQTEASHLLHIFANTK 20107
21368 GRPFNPRTSIVHAIANIICAVVFGHRFSSEDESFSKLIKAVYFVIYFQATIWGR (0) 21529
21710 MYDAFPWLMHRFPGPHQKVFAYNNFMHNLVMNEIQMHEREKAGDPQDLIDFYLTQIAK 21884
22115 TKDDPTSTFNKDNMVQTVVDLLLGGTETTSTTLLWALLYMVQYPEIQ 22255
22786 ERVQREIEAVLEPSHVISYEDRKRLPYTNAVIHETLRYSNITSVGVPRLCVRNTTLLGFHIKK 22974
23285 GTLVLPNLHSVVYDSDHWATPCKFDPNHFLDVDGNFVNKEAFLPFSA 23425
23644 GHRVCLGEQMARVELFIFFTNLLRAFTFQLPEGVKEINPEYVLGAILQPHPYEICAVPR 23820
CYP2AB2 Gallus gallus (chicken)
XM_422750 2 P450s fused together during annotation error
chr9:15,031,052-15,037,949 (-)
MGINVLSPPEKNSEFYHVLFLLGLQFLRLQWRSRRFPPGPIPFP
IIGSIWWINFRADHGSLKKLAKAYGNICTLWLGHKPIVVLYGFKAVKDGLTTNSEDVS
GRLQTYLFNRFSSGKGTAEFQWMEHRVLYLKQEWLNWFLPASYPSKHRGTRIGSLQTS
PMGSSEKSIGLEQLSERDHRISWWEKPEHQRRFGIATLRKLGMGNKGMERGIQAEARH
LVEFFRSKDGRAVDPSFPIVHAVSNVICAVVFGHRFSLQDETFRRLMEAYNGIVAFGN
SYFYYTKNVPNSTYDEENMLQSVFDLFLGGSETTATTLRWALLYMVAYPDIQEKVQKE
LDAVLGSSHQIDYEDRKKLPYTNAVIHEIIRFSSIILITIPRQAVKDTTVLGYQVPKG
TIIMANIDSTLFDPEYWETPHQFNPGHFLDKDGNFVIREAFLAFSAGHRVCLGEVMAK
MELFIIFCSLLQIFKFTPPEGDKEINLSFVFGSTMKPHPYKL
CAVLR
CYP2AB3 Gallus gallus (chicken)
XM_422750 2 P450s fused together during annotation error
chr9:15,022,695-15,027,829 (-)
46% to mouse 2ab1
7270 MLAVSAVLVCLAASLLLVQFLGMQWKRRQLPPGPAPFPLFGNLLQMKFQIHHDILXX 7106
MASMYGNIFTLWLTGTPVVVLHGY 6690
6689 QAVKEGMTAHAEEVAGRPLSRAFRLMTNGN 6618
6266 GVMFSNGHLWKQQRRFGLLTMRKMGVGKQNQECQIQEEAHHLVQYLRNTK 6117
5699 GKPLDPAVPVTHTVSNVICALILGHRFSIEDKRFLRLVEAVDDISAFANSVSFY 5538
4840 VHDQVPWIATHFLTRCKKALASIDTMRALLEEEIGSHKGKVDENQDFIGYYLDQMAK 4670
4111 SKEDAGATYDKANLLQTIFDLFLAGTETTATTLRWALLYMVAYPDVQ 3971
3128 KKVHKELDAVLGSSRLICYKDRKNLPYTNAVIHEIQRYSNIVLIALPRYTVKDTELLGFPIPK 2946
DTIVLVNID 2769
2768 SVLSDPEKWETPDQFNPGHFLDKDGNFVHREAFLPFSI 2655
2354 GHRACMGELLARLELFIIFCTLLQAFTFTLPDGVNEVSTKFVFSS 2178
2177 TKKPPPHQICAIPR 2136
CYP2AB4 Gallus gallus (chicken)
XM_426708 seq was added to mRNA translation to correct it
chr9:15,009,527-15,018,429 (-)
MNPVKAAAMLSINQVMIALVVFLLVMQFLKLQRARRCLPPGPIP
LPVLGTLLQLNFQINRDVLMKLAKTYGNVFTLWFGWAPVIILNGFQAVKDGMTTHPED
VSGRLVSPFFRAMAKGKGIMLATGHMWKQQRRFALKTLRNLGLGKRGLEQRVQEEALH
LLEFFASLKEKPLDPYYPLIHSVSNVICAVVYGHRFSRGDETFHELIRATEHIFKFGG
SLLHHLYEIFPWLMCRLPGPHKKALSCYDILSSFTRREIREHKEREIPDEPRDFIDFY
LAHIEKSGDEPKSTYNEENMVYSINDLFLGGSETTSTTLNWGLLYMVAYPDVQEKVQK
ELDAVLGPSQMICYEHRRKVPYTNAVIHEIQRFSNIISIGMPRVCVRNTTLLGFPLKK
GSIVLPNIASSLYDP
EHWETPRQFNPAHFLDKDGNFVSQEAFLPFSIGHRVCLGEHLARTELFIFFANLLRAF
TFQLPEGVTTINTEPIFGGTLQPHPYKVCAIPR
CYP2AB1 Xenopus laevis (African clawed frog)
GenEMBL BC074149.1
46% to 2AB1P hum, 49% to mouse, 54% to chicken
MSFTQETWSLQQILLAFLVCVIAVKYIKMRWAA
RSLPPGPTPLPLIGNLWALRFKLHPKTLRKIAVSYGDIYTLWLGHTPLVVLSGCRSVRNG
LISHSEELSGRPVDGLMQALTNERGIGSTNGHTWKQQRRFGLMTLRNLGLGKRGLESRIQ
EEAQCLVESLAAKNGEPVNPSDLIVHAVANVISAVVFGHRFSIEDPTFQEMVRCNGCIVT
NLGTAWGRIYDAFPWLMRFV PGPHQSSFAAMAYLTAFIKKEIKLHELNGPNEQPQDLIEY
YLAQIAKTKHEPDNTFDEANMIQTVI DLFIAGTETTATSLQWALLYMVAFPEIQKKVQEE
LDTVLDGSQLAYYEDKKRLPFTNAVIHEVQRYGNIASVGMLRSCIRKVTVNGYQLEKNTM
VLPNLDSVLHDQHQWETPYKFNPNHFLDKNGNFCTSEAFLPFSAGHRVCLGEQLARFELL
IFFTTLLRRFNIELPEGITEVNTKYVFKMTLQPHPYEICAVPR*
CYP2AB1 Xenopus tropicalis (frog)
GenEMBL CX984262.1 CX984263.2 ESTs
scaffold_535:154,346-161,099
131 MSFTQDTWSFQQILLALLVCVITIKYIKMKWAAKNLPPGPTPLPLLGNLWALRFKLHP 304
305 KTLRKMAKSYGDIYTLWLGHTPLVVLSGCKSVRNGLITHSEELSGRPVDGFMTALTNERG 484
485 IGTTNGHTWKQQRRFGLMTLRNLGLGKRGLESRIQEEAQCLVESLAAKNGEPINPSDLIV 664
665 LAVANVISAVVFGHRFSIEDPTFQEMVKCNSSLVSGLGTAWGRMYDAFPWLMRYV 829
PGPHQKSFAAIDYLAAFIKKEIKLHEINSSKDDPQDMIDYYLTQIEK (0)
TKHELDTTFDEENMIQVVI
893 DLFIAGTETTAISLSGALLYMVAFPEIQKKVQKELDTVLDGSPLAYYEDRKKLPFTNAVI 714
713 HEVQRYGNIASVGIPRSCIRKVTVNGYQLNKNTIVLPNLDSVLHDQRQWETPYKFNPNHF 534
533 LDKNGDFCTNEAFLPFSAGHRVCLGEQLARFELFIFFTTILRRFSIELPKGVTEVNTDYV 354
353 FKMTLQPHPYEICAIPR 303
2AC Subfamily
CYP2AC1P human
AC022650 6p12.3 41% to 2C9 pseudogene 2 in frame stops
68% to rat CYP2AC1 (XM_236969.1) functional gene
old name CYP2C57P
GIAFSHGETWKTMRRFSLTTLRNFGMGEWIIEDTIIEECQNLIQ
NMFLVLGFLLKSHKTILRNRDELFSFIRMAFLDHHHKLDKNDPRNFTDVFLVTQQE
ENDTFADYFSDKKLVTLVNNLFTTGTETTASTLHWGILLVMRYPEVQS
KVHNEITKVVVSAQS*LAHRTQMTHTDAVI*EVQRFANILPTSLSHATTTNIFKNYCIPK
GTEVIILLASVARDQAQWEKPDTFNPEHFLNSKEKFIKREAFLPF
CYP2AC1P Bos taurus (cow)
See cattle page for details
67% to rat 2AC1
MSGFESSFILPILSLILIFILNIKIVMTKASKQHFPPVPRPLPIIGNLHILNLKRPYQTMLE (0)
LSQKYGSIYSIQIGPRKVAVLxGYETVKDVLVNHTDQFGEWFHVPISERLFEGK
GIFFSHSDTSKIIRFTLTTSQNFGMGKKALEDTIIGESQHLIRNFETDKG
GKPFEVKTLTNASVANINVSVLLGKGFDYQNTPFLRLLTLIDQSVKLIVSPPTA
LFNMFPVLRFLLKTYKNILRNKDELFSFIRMTFLHHHHKLDKNDPRSLTDAFLVRQQE
DTSTDYFNDDTLVVLVNNLFAAGTESMVSTLCWGILFMSRYPEIQS
KVHDEIAKVMGSTQP*MAH*TQMPYTDAVILEVQRFADILPTGLPRATTTNTIFKNNYIPK
GTEVIFLLTSVL*DQTQWENPATFNPEHFLDSIEKFIKKEAFISFSV (1)
SPL*CAGESLAKMELLLFFMSLLQKFTFQPPPGVSHLDLDPTRDTGVVIQPMPHKIRALPRA
CYP2AC1 Canis familiaris (dog)
XM_847513.1
MSGFDSSIILPILSLLLIFLLNIKIFMTKASKQHFPPGPR
PLPIIGNLHILNlkrpyqtmleLSQKYGSIYSIQMGPKKVVVLSGYETVKDALVNYGD
QFGERSQVPIFERLFEGKGIVFSHGETWKTMRRFSLATLRNFGMGKRIIEDTIIEECQ
HLIWSFESHR GKPFEVKTVMNASVANVIVSVLLGKRFDYQDTQFLRLLTLIGENVKLI
GGPRIA
LFNMFPVLGFLLKSHKTVLRNRDELFAFIRMTFLDHQHKFDKNDPRSFIDAF
LVRQQE EKDTSTTYFSDENLVALVSNLFAAGTETTATTLCWALLLMMRYPEVQKKVCD
EITKVVGSAQPRITHRTQMPYTDAVIHEVQRFANILPTGLPHATTTNVMFKNYYIPKG
TEVITLLTSVLRDQTQWEKPDTFNPNHFLSSTGKFIKKEAFMPFSLGRRMCAGESLAK
MELFLFFTSLMQKFTFQPPPGVSHLDLDLTPDIGFTTRPMPHKICALLRA*
CYP2AC1 Monodelphis domestica (short-tailed opossum)
XM_001369570.1
MSNGGHSLVPQMSIEFWEQRPTQGANIYHGHYPPGPKPLPVIGN
LHILNLKRPYQTMLELSKKYGPIFSLRMGPKTVVVLSGYETVKDALVNYSEQFGERAR
IPIFERIFEGKGIVFSHGENWKITRRFSLTTLRNFGMGKRVIEERILEECHHLIQVFE
SHQGKPFEISTIMSASVANIIVSILFGKRFDYKDPQFLRLLHLIGENIRLAGGPSITI
FNMFPVLGFLLQDLKRVLRNRDELFSFIRTTFLKHLRKLDKNDQRSFIDAFLIKQQEK
DKSDDYFNNDNLVALVSNLFAAGTETTSSTLRWGILLMMKYPEIQKKVHNEITEVIGS
AQPRIEHRTQMPYTDAVIHEIQRFSNILPMNLSRETTTDVIFKNYYIPKGTEVITLLT
SVLQDQTQWEKPCTFHPQHFLTKEGKFIKRDAFLPFSAGQRMCAGESLAKMELFLFFT
SLLQKFTFCPSPGVSNSDLDLTPDIGFTTRPQPYKICALPYF
Cyp2ac1-ps mouse
GenEMBL NW_000130.1|Mm17_WIFeb01_308
MISSING EXON 2 probably in a seq gap
Rat ortholog is 80% identical
MSGFDFSAMLALLGLSLILILHINVFMAKASKHQSPPGRKSWPVIGNLHIXXXXXXXXXXXX
GIAYAHGKCWKTMRRFSLTTLRNFLMGKRIIEDTIVTECQHLIQCFESHK
GLVLGM*RLLKASIANVIVSVLLGKWFDYQDSQFLRLLTLIGENMKLIGNPSIV
LLNMFPILGFLLRSKKKVLRNRVELFSFIRMAFLEHCHNRNKSDPRSLIDAFLVRQQG
ENNTSANHFNEENLLALVSNLFTARTKTTASTLHWGIILMMLYPEVQS 556747
KVRGEIIKVVGSAQPRIEHRIQMPYTDTVIHEIE (fs) RVANILPTSLFHETTTDVAFKNYYIPK
GTEIITLLTSVLQDQTQWEASDAFDPAHFLSPKGTFVKKESFVPFSW 561380
GCHMCAGEPLAKMELFLFFTSLMQKFIFQSPxx (fs) VSHLDLDLTPDIGFIMQSQPHKICALVRASAL
CYP2AC1 Rattus norvegicus (rat)
GenEMBL NW_044163.1|Rn9_1523
genomic ortholog to 2ac1 chromosome 9
3425457 MSGFDFSAILALLGLILILILNIKDFMAKASKRQCPPGPKPWPVIGNLHILNLKRPYQTMLE 3425272
3423187 LSKKYGPIYSIQMGPRKVVVLSGYETVKDALVNYGNQFGERSQVPIFERLFDGK 3423026
3415443 GIAFAHGETWKTMRRFSLSTLRDFGMGKRTIEDTIVVECQHLIQSFESHK 3415294
3412018 GKPFEIKRVLNASVANVIVSMLLGKRFDYEDPQFLRLLTLIGENIKLIGNPSIV 3411857
3410639 LFNIFPILGFLLRSHKKVLRNRDELFSFIRRTFLEHCHNLDKNDPRSFIDAFLVKQQ 3410469
3410029 ENNKSADYFNEENLLALVSNLFTAGTETTAATLRWGIILMMRYPEVQS 3409886
3408812 KVHDEIHKVVGSAQPRIEHRTQMPYTDAVIHEIQRVANILPTSLPHETSTDVVFKNYYIPK 3408627
3406238 GTEVITLLTSVLRDQTQWETPDAFNPAHFLSSKGRFVKKEAFMPFSV 3406098
3402907 GRRMCAGEPLAKMELFLFFTSLMQKFTFQPPPGVSYLDLDLTPDIGFTIQPLPHKICALLRTSAL* 3402710
CYP2AC1 Xenopus laevis (African clawed frog)
GenEMBL CB558367.1 NICHD_XGC_Kid1 Xenopus laevis cDNA clone
CB559919.1 NICHD_XGC_Kid1 Xenopus laevis cDNA clone
BJ030802.1 NIBB Mochii normalized Xenopus neurula cDNA clone
61% identical to rat 2ac1 from PPGP to end
MFLGDPVTVLLTVVLCLILANLLYGRKRNNFKNF
PPGPKPLPVIGNINIINLKRPYLTYLELWKKYGPVFSIQIGGQKMVVLCGYETVKDALVNYAEEFSERPK
IPIFRDISKEYGVLFSHGENWKVMRRFTLSTLRDFGMGRSSIEDRINEECDFLVEK
FKSYKGKPFENTMIINAAVANIIVSIILGHRFDYQDPIFLRLMSLINENIRLSGSPTVML
YNVFPSVMRWLPGSHKTIAKNAAENQR
FIRKTFTKHRDKLDVNDQRTLVDAFLVKQQEKNVNVQYFHDENLTMIVSNLFAAGMETT
SSTIRWGLLLMMKYPEIQKNVQNEIEKVIGQSQPQTEHRKSMPYTDAVLHEIQRFGNIVP
MNLPHATAQDVTFRGYFLPKGTFVIPLLTSVLYDQTHFEKPHEFYPQHFLDSEGNFVKNE
AFLPFSAGKRSCAGENLAKTELFLFFTSLLQNFTFQASSGRRT*
CYP2AC1 Phalacrocorax carbo (Common cormorant)
No accession number
Hisato Iwata
submitted to nomenclature committee 5/19/05
61% to CYP2AC1 rat 76% to 2AC1 chicken 70% to 2AC2 chicken
CYP2AC1 Gallus gallus (chicken)
NW_060338.1|Gga3_WGA147_1 chr 3
XM_420052.1, BG641890.1 EST BU120706.1
3967773 MDWASVVPVGLLMILILLLILKTQDFWRSQGKFPPGPQPLPIIGNLHIMDLKKIGQTMLQ (0) 3967952
3968877 LSETYGPVFTVQMGMRKVVVLSGYDTVKEALVNHADAFVGRPKIPIVEKAGKGK 3969038
3969203 GVVFSSGENWKVMRRFTLTTLRDFGMGKKAIEDYVVEEYGYLADVIESQK 3969352
3970285 GKPLEMTHLMNSAVANVIVSILLGKRFEYEDPTFKRLVSLINENMRLFGSPSVS 3970446
3971108 LYNMFPILGPFLKDNKSFLENVKEVNDFIKVTFTKYLQVLDK 3971233
3971234 NDQRSFIDAFLVKQQE 3971281
3971703 QNEKANKFFDDENLTEVVRNLFTAGMDTTATTLRWGLLLMMKYPEIQ 3971843
3971973 KKVQEEIDRVIGSNPPRTE 3972029
HRTKMPY
3972269 TDAVIHEIQRFANILPLNLPHETTMDVTIKGYFIPK 3972376
3972609 GTYIIPLLNSVLQDKTQWEKPCSFHPEHFLNSEGKFVKKDAFIPFSA 3972749
3973027 GRRICAGETLAKMELFLFFTSLLQRFTFQPPPGISSSDLDLSAPPRFVIAPVTHEVCAVSRS 3973212
CYP2AC2 Gallus gallus (chicken)
NW_060338.1|Gga3_WGA147_1, chr 3
BG710846.1 EST, XM_420053.1
3974997 MALVFILTFLFIMKIGGLWSNHWRKNFPPGPRALPIIGNLHLFDLKRPYRTYLQ 3975158
3976589 LSKEYGPVFSVQMGQRKIVVISGYETVKEALINQADAFAERPKIPIFEDLTRGN 3976750
3977081 GIVFAHGENWKVMRRFTLTTLRDFGMGKRAIEDRIVEEYGYLIDNVGSQE 3977230
3977626 GKPFDASKIINAAVANIIVSILLGKRFDYKDSRFIRLQHLTNESMRLAGKPLVT 3977787
3978987 MYNIFPYLGFLLRANKTLLKNRDEFHAYVKATFLENLKTLDKNDQRSFIDAFLVKQQE 3979160
3979765 EKSITNGYFHNGNLLSLVSNLFTAGVETISTTLNWSFLLMLKYPEIQSKVQ 3979917
3980773 EEIEQVIGSNPPRIEHRTQMPYTDAVIHEVQRFANILPLDLPHETAEDVTLKDYFIPK 3980946
3981123 GTYIIPLLTSVLRDKSQWEKPDMFYPEHFLDSKGKFVKKDAFMPFSA 3981263
3982308 GRRICAGETLAKMELFLFFTSLLQRFTFQPPPGVSSSDLDLSPAISFNVVPKPYKICAVARS 3982493
2AD Subfamily
CYP2AD1 Fugu rubripes (pufferfish)
No accession number
Scaffold_805, Old Scaffold_3261d
Formerly CYP2N12
92399 MILQKIFAYMDFSSWVLLIFLVLLITDVIRNWTPHNFPPGPWAMPFVGNIFTGVDFRTIEK (0) 92217
92102 LSQKYGPVFSLRRGNTRTVFINGYKMVKEALVSQLDSFEDRPVVPLFHVVFKGI (1) 91941
91785 GIALSNGYMWKKQRKFAHTHLRYFGEGQKLLENHIQMESKFMCEAFKDEQ 91633 (1 gc
boundary ?)
91552 GKPFDPQYTITNAVGNIISALVFGHRFEYSDASFRRILELDNEAVVLAGSARTQ 91391 (0)
91307 LYDSFPSLMKHLPGPHQTVHANYGKITDFLKKEVDKHMEEWNPEDPRDYVDTYLSEMEK 91131 (0)
90784 MNQDPQGGFNVETLLICILDLIEAGTESAATTLRWGLVFILNYPDVQ 90644 (1)
90564 EKVQEEIDRVIGQSRQPAMADRPNMPYTDAVIHEIQRFANVVPAGFPKMATKDTTVGGYFIPK 90376
(0)
90287 GLAITTMLSSVLFDKNEWETPDVFNPNHFLDSEGRFRKRDAFIPFSA 90147 (1)
90043 GKRVCIGENLAKMELFLFFTSILQHFNLSPVPGQMPSLEGILGFTYSPQPFRMIVAPR* 89867
CYP2AD2 Danio rerio (zebrafish)
GenEMBL AF248042
Tanguay R.L.
75% to 2AD3
MILHLIYDSFDFKSWIIFFVVFLIIAEMIKNRTPSNYPPGPWPL
PFLGTVFTKMDFKNINKLAKVYGKVFSLRVGSEKMIIVSGYKMVKEALVTQNDSFVLR
PPVPLFHKVYKGIGLTMSNGYIWRSHRRFAASHLRTFGEGKKNLELGIQQECVYLCDA
FKAEKEPFNPIFILHGAVSNTVACLTFGQRFDYNDEWYQEILRLDNQCVQLAGSPRVQ
LYNAFPKLLDYLPGPHQKVFSNYKKITQSLKDEIIKHREDWDPANPRDFIDNYLTEME
KKKSDPQAGFNIESLIISCLDIVEAGTETGATTLRWGLLFMIKFPEIQKKVQAEIDRV
IGQSRQPCLDDRVNMPYTEAVLHEIQRFGDVVPLGFPKQAAVDTKIGNYFIPKGTSIT
TNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRKRDAFLPFSAGKRACVGELLARNVLF
LFFTSLLQQFTLSKCPGEEPSLEGEIWFTYAPAPFRISVSVR
CYP2AD3 Danio rerio (zebrafish)
No accession number
Tseng, H.-P., Wang-Buhler, J.-L., Yang, Y.-H.,
Hu, C.-H., Buhler, D.R.
submitted to nomenclature committee 12/08/2003
75% to CYP2AD2 60% to CYP2AD1
clone name YH-B1-FL
CYP2AD4 Oryzias latipes
GenEMBL BJ494553 EST
70% to CYP2AD1
CYP2AD5 Gasterosteus aculeatus
GenEMBL CD499490 EST
67% to CYP2AD1
CYP2AD6 Danio rerio (zebrafish)
CYP2AD7 Oryzias latipes (medaka)
chr4 28086098:28094682
Joanna Wilson and students
submitted to nomenclature committee Jan. 25, 2008
61%ID to Zebrafish 2AD2
73% to 2AD1 (FORMERLY 2N12)
probable GC boundary based on mRNA EF546460.1
MIFQALFDRMDFNSWLVFGFVLLLLIDIVKTWKPPKFPPGPLSVPFLGNVFTGVDFKTMEKLSQDFGPVFSLRRG
SERMVFISGYKMVKEALVTQLDSFVDRPIVPLFHVVFKGLGIALSNGYLWKKQRKFANAHLRYFGEGQKSLERYI
EIESNFLCDAFKEEQ (1 GC boundary)
GRPFNPHYLITNAVGNIISSVVFGHRFEYSDPSFRKVLELDNEAVVLSGSARTQLYDAFP
SLLNYLPGPHQTVHANYREIVCFLRKEIEKHQEEWNPEDPRDYIDVYLSEMEKTKQDPQAGFNIETLVVSTLDLI
EAGTETTATTLRWGLMFMLHHPEIQEKVQEEIDRVIGQSRQPAMSDRPNLPYTDAVIHEIQRMGNIVPLGFPKMA
SKDTTLGGYFIPKGTPITTILSSVLFDKNEWETPHVFNPGHFLDSEGRFLKKEAFLPFSAGKRMCLGEHLAKMEL
FLFFSTLLQRFTFKPVPGEMPSLEGVLGFTHSPEEFRFLALPR*
2AE Subfamily
CYP2AE1 Danio rerio (zebrafish)
NA7219 zfishG-a147a09.q1c zfishG-a1551g08.q1c Z35723-a848d07.q1c
49% to 2P6 48% to 2N13 46% to 2V1 46% to 2AD2
28876 MSSVFSQLIGQWLDVQGFLIFLCVLLLVKHFRDVYSKNMPPGPFPLPFVGNLTNIGFSDP 28715
28714 LGSFQR 28697 (0)
28473 IAEKYGDVCTLYLGTKPCILMTGYDTLKEAFVEQADIFTDRPYFPIVDKLGN 28336 (1?)
26270 AGLIMSSGHMWRQQRRFALATLKYFGVGKKTLENAILQECRFLCDSLQAER 26118
25139 GLPFDPQHLVTNAVSNIICGLVFGHRFEYDDHQFHLMQTYINNILQLPISNWGR 24978
24700 LYNEFPTLMSLLPGKHQTAFASMSKLQPFLKEEITKHQQDREPSSPRDYIDCYLEEIEK 24524
21648 QCKDSDAEFTEENLMFCVVDLFGAGTETTSNTLRWALAFMVKYPDVQ 21508
21386 EKVQSEIDQVIGQTRQPLMDDRTNLPYTYAVIHEIQRFANIVTFTPPRVANKDTTVGGQLIPK 21198
18506 GVIVLPMLKPILLDKKEYSTPYDFNPDHFLDQNGKFLKKENFIPFSI 18366
14291 GKRMCPGEQLAGMELFLFFISLMQHFTFLPPEGETLSLKIFLAIASAPAPFRI 14133
KAVPRQCDNTAS*
CYP2AE1-de9 Danio rerio (zebrafish)
NA7219
extra exon 9 6kb downstream of 2AE1
8074 GKRMCPGEQLARMELFLFFISLMQHFTFLPVEGQKLSLKGTTSVSSAPQPFQI 7916
2AF Subfamily
CYP2AF1 Phalacrocorax carbo (Common cormorant)
No accession number
Hisato Iwata
submitted to nomenclature committee 5/19/05
45% to 2C11 rat
this is a new vertebrate subfamily