Bacterial phylogeny of Cavalier-Smith (2002) showing P450s

(to the level of Class)

    Note: Division rank is equivalent to phyla

 

Kingdom Bacteria (501)

 Subkingdom Negibacteria (157)

  Infrakingdom Eobacteria (7)

    Division Eobacteria (7)

       Class Chlorobacteria (1)

       Class Hadobacteria (6)

  Infrakingdom Glycobacteria (150)

    Division Cyanobacteria (28)

     Subdivision Gloeobacteria (3)

       Class Gloeobacteria (3)

     Subdivision Phycobacteria (25)

       Class Chroobacteria (9)

       Class Hormogoneae (16)

    Division Spirochaetae (0)

       Class Spirochaetes (0)

    Division Sphingobacteria (1)

       Class Flavobacteria (1)

       Class Chlorobea (green sulfur bacteria) (0)

   Superdivision Exoflagellata (121)

    Division Planctobacteria (1)

       Class Planctomycea (1)

       Class Verrucomicrobiae (0)

       Class Chlamydiae (0)

    Division Proteobacteria (120)

     Subdivision Rhodobacteria (114)

       Class Chromatibacteria (beta and gamma) (38)

       Class Alphabacteria (76)

     Subdivision Thiobacteria (6)

       Class Deltabacteria (5)

       Class Epsilobacteria (1)

     Subdivision Geobacteria (0)

       Class Ferrobacteria (0)

       Class Acidobacteria (0)

 Subkingdom Unibacteria (344)

    Division Posibacteria (338)

     Subdivision Endobacteria [low G+C] (24)

       Class Togobacteria (0)

       Class Teichobacteria [Firmicutes] (24)

       Class Mollicutes (0)

     Subdivision Actinobacteria [high G+C] (314)

       Class Arthrobacteria (1)

       Class Arabobacteria (139) (120 without M. bovis)

       Class Streptomycetes (193) 5 alleles subtracted

    Division Archaebacteria (6)

     Subdivision Euryarchaeota (4)

       Class Methanothermea (0)

       Class Archaeoglobea (0)

       Class Halomebacteria (2)

      Superclass Eurythermea

       Class Protoarchaea (0)

       Class Picrophilea (2)

     Subdivision Crenarchaeota (2)

       Class Crenarchaeota (2)

 

 

Bacterial phylogeny of Cavalier-Smith (2002) showing P450s

(to the level of Species)

    Note: Division rank is equivalent to phyla

 

Kingdom Bacteria (501)

 Subkingdom Negibacteria (157)

  Infrakingdom Eobacteria (7)

    Division Eobacteria (7)

       Class Chlorobacteria (1)

        Chloroflexus aurantiacus (1)

       Class Hadobacteria (6)

        Deinococcus radiodurans (5)

        Thermus thermophilus (1)

  Infrakingdom Glycobacteria (150)

    Division Cyanobacteria (28)

     Subdivision Gloeobacteria (3)

       Class Gloeobacteria (3)

        Gloeobacter violaceus (3)

     Subdivision Phycobacteria (25)

       Class Chroobacteria (9)

        Microcystis aeruginosa (1)

        Prochlorococcus marinus str. MIT 9313 (1)

        Synechococcus sp. WH 8102 (1)

        Synechocystis sp. (1)

        Trichodesmium erythraeum (5)

       Class Hormogoneae (16)

        Nostoc punctiforme (9)

        Nostoc sp. PCC 7120 (7) same as Anabaena

    Division Spirochaetae (0)

       Class Spirochaetes (0)

    Division Sphingobacteria (1)

       Class Flavobacteria (1)

        Microscilla sp. (1)

       Class Chlorobea (green sulfur bacteria) (0)

   Superdivision Exoflagellata (121)

    Division Planctobacteria (1)

       Class Planctomycea (1)

        Pirellula sp. (1)

       Class Verrucomicrobiae (0)

       Class Chlamydiae (0)

    Division Proteobacteria (120)

     Subdivision Rhodobacteria (114)

       Class Chromatibacteria (beta and gamma) (38)-2 alleles

        Acinetobacter calcoaceticus (1)

        Azotobacter vinelandii (1)

        Bordetella bronchiseptica (1)

        Bordetella pertussis (1)

        Bordetella parapertussis (1)

        Burkholderia fungorum (6)

        Chromobacterium violaceum ATCC 12472 (1)

        Citrobacter braakii (1)

        Erwinia herbicola (1)

        Methylococcus capsulatus (1)

        Photorhabdus luminescens (2)

        Pseudomonas aeruginosa (4)

        Pseudomonas fluorescens PfO-1 (3)

        Pseudomonas putida (2)

        Pseudomonas diterpeniphila (1)

        Pseudomonas incognita (1)

        Pseudomonas sp. (2)

        Ralstonia metallidurans (4)

        Ralstonia solanacearum (1)

        Xanthomonas axonopodis pv. citri str. 306 (1)

        Xanthomonas campestris pv. Campestris (2)

        Xylella fastidiosa (2 P450s plus alleles)

       Class Alphabacteria (76)

        Agrobacterium tumefaciens (7)

        Bradyrhizobium japonicum (16)

        Brucella melitensis (1)

        Caulobacter crescentus (4)

        Magnetospirillum magnetotacticum (4)

        Mesorhizobium loti (7)

        Novosphingobium aromaticivorans (15)

        Rhizobium etli (5)

        Rhizobium sp. (5)

        Rhodobacter sphaeroides (2)

        Rhodopseudomonas palustris (7)

        Sinorhizobium meliloti (2)

        Sphingomonas paucimobilis (1)

     Subdivision Thiobacteria (6)

       Class Deltabacteria (5)

        Myxococcus xanthus (2)

        Sorangium cellulosum = Polyangium cellulosum (2)

        Stigmatella aurantiaca (1)

       Class Epsilobacteria (1)

        Campylobacter jejuni (1)

     Subdivision Geobacteria (0)

       Class Ferrobacteria (0)

       Class Acidobacteria (0)

 Subkingdom Unibacteria (344)

    Division Posibacteria (338)

     Subdivision Endobacteria [low G+C] (24)

       Class Togobacteria (0)

       Class Teichobacteria [Firmicutes] (24)

        Bacillus anthracis str. Ames (3)

        Bacillus cereus ATCC 14579 (6)

        Bacillus subtilis (9 P450s)

        Bacillus halodurans (1)

        Bacillus megaterium (3)

        Clostridium acetobutylicum (1)

        Enterococcus faecium (1)

       Class Mollicutes (0)

     Subdivision Actinobacteria [high G+C] (314)

       Class Arthrobacteria (1)

        Arthrobacter aurescens (1)

       Class Arabobacteria (139) (120 without M. bovis)

        Actinosynnema pretiosum subsp. Auranticum (1)

        Amycolata autotrophica = Pseudonocardia autotrophica (3)

        Amycolatopsis mediterranei (8)

        Amycolatopsis orientalis (8)

        Corynebacterium efficiens YS-314 (1)

        Corynebacterium glutamicum ATCC 13032 (1)

        Lechevalieria aerocolonigenes

          = Saccharothrix aerocolonigenes (1)

        Micromonospora echinospora (2)

        Micromonospora griseorubida (2)

        Micromonospora inyoensis (1)

        Mycobacteruim abcessus (1)

        Mycobacteruim avium (4)

        Mycobacteruim bovis (19) same set as tuberculosis

        Mycobacteruim leprae (11)

        Mycobacteruim smegmatis (40)

        Mycobacteruim tuberculosis (20)

        Mycobacteruim ulcerans (1)

        Mycobacteruim species (2)

        Nocardioides sp. (1)

        Rhodococcus erythropolis (1)

        Rhodococcus fascians (1)

        Rhodococcus rhodochrous (1)

        Rhodococcus ruber (1)

        Rhodococcus sp. (2)

        Saccharopolyspora erythraea (4)

        Saccharopolyspora spinosa strain NRRL (1)

        Streptoalloteichus hindustanus (1)

       Class Streptomycetes (193) 5 alleles subtracted

        Actinomadura hibisca (1)

        Actinomadura madurae (1)

        Actinomadura verrucosospora (1)

        Actinomadura sp. ATCC 39727 (4)

        Kitasatospora griseola (2)

        Streptomyces acidiscabies (1)

        Streptomyces albofaciens strain C-0083 (1)

        Streptomyces albus (1)

        Streptomyces ansochromogenes (1)

        Streptomyces antibioticus (3)

        Streptomyces atroolivaceus (2)

        Streptomyces avermitilis (33)

        Streptomyces caelestis (1)

        Streptomyces carbophilus (1)

        Streptomyces carzinostaticus (2)

        Streptomyces chattanoogensis DSM-40241 (1)

        Streptomyces cinnamonensis (1)

        Streptomyces clavuligerus clavulanic (1)

        Streptomyces coelicolor (18)

        Streptomyces collinus (1)

        Streptomyces fradiae (3)

        Streptomyces glaucescens (1)

        Streptomyces globisporus (2)

        Streptomyces griseolus (2)

        Streptomyces griseus (5)

        Streptomyces hygroscopicus (7)

        Streptomyces kasugaensis strain A/96 (1)

        Streptomyces lavendulae (5)

        Streptomyces lividans (1)

        Streptomyces lydicus strain NRAB-0114 (3)

        Streptomyces maritimus enterocin (1)

        Streptomyces nanchangensis (2)

        Streptomyces narbonensis (1)

        Streptomyces natalensis (2)

        Streptomyces nodosus (2)

        Streptomyces noursei (2)

        Streptomyces peucetis (19)

        Streptomyces platensis (3)

        Streptomyces rimosus ssp. paromyceticus (2)

        Streptomyces rochei (3)

        Streptomyces roseochromogenes subsp. Oscitans (1)

        Streptomyces sclerotialus (1)

        Streptomyces sp. (16)

        Streptomyces spheroides (1)

        Streptomyces tendae (2)

        Streptomyces thermotolerans (1)

        Streptomyces toyocaensis (3)

        Streptomyces tubercidicus (12)

        Streptomyces venezuelae (1)

        Streptomyces virginiae (1)

        Thermobifida fusca (10)

    Division Archaebacteria (6)

     Subdivision Euryarchaeota (4)

       Class Methanothermea (0)

       Class Archaeoglobea (0)

       Class Halomebacteria (2)

        Halobacterium sp. NRC-1 (1)

        Methanosarcina barkeri (1)

Superclass Eurythermea

       Class Protoarchaea (0)

       Class Picrophilea (2)

        Ferroplasma acidarmanus (2)

     Subdivision Crenarchaeota (2)

       Class Crenarchaeota (2)

        Sulfolobus solfataricus (1)

        Sulfolobus tokodaii (1)

 

Bacterial Cytochrome P450s ranked by most abundant taxons

 

Actinobacteria (includes Mycobacterium and Streptomyces = 297 P450s)

 

Mycobacterium smegmatis (40 [mostly] unnamed P450s) Actinobacteria

CYP51    Mycobacterium smegmatis TIGR contig:3439

CYP151A1 Mycobacterium smegmatis AF102510

CYP150A2 Mycobacterium smegmatis AF107047

 

Mycobacterium bovis 19 P450s

same as tuberculosis except CYP130A1 is deleted in bovis

and CYP141A1 and CYP142A1 are pseudogenes

bovis and tuberculosis sequences are 100% matches or just 1 aa diff.

 

Mycobacterium tuberculosis (20 P450s) Actinobacteria

 

CYP138              163364..164689

CYP135A1 complement(392694..394043)

CYP135B1            659448..660866

 

operon followed by a ferredoxin order = hypo. CYP123 oxido CYP51 ferredoxin

complement(860067..860708) hypothet. protein

CYP123   complement(858862..860070)

stop of CYP123 overlaps start of this protein

complement(858035..858862) probable OXIDOREDUCTASE

CYP51    complement(856680..858035)

         complement(856471..856677) ferredoxin 208bp downstream

 

CYP126              871429..872673 adenylosuccinate lyase = 4b upstream

CYP130   complement(1403384..1404601) overlaps dowstream to regulatory protein

         complement(1402776..1403384) potential acrab operon repressor

CYP132   complement(1569582..1570967)

         complement(1568107..1569585) Probable monooxygenase,

                     similar to e.g. CYMO_ACISP P12015 cyclohexanone

                     monooxygenase (stop of CYP132 overlaps this protein start

CYP139  complement(1892268..1893560)

CYP144             2010654..2011958

CYP143A1 complement(2023445..2024626)

                    2024826..2025029 ferredoxin opposite strand 199bp

                    could share common divergent promoter

CYP140A1 complement(2130539..2131855)

CYP124A1            2540102..2541388

CYP128A1 complement(2542805..2544274) end of CYP128 overlaps Rv2267c

         complement(2541642..2542808) hypothetical protein Rv2267c

                    2546881..2547750  hypothetical protein Rv2275

                          end of Rv2275 overlaps CYP121 start

CYP121              2547747..2548937

CYP136A1            3419489..3420967

CYP141              3486506..3487708

CYP142   complement(3954321..3955517)

CYP125A1 complement(3984140..3985441)

         complement(3983121..3984140) Acyl-CoA Dehydrogenase

         complement(3981973..3983136) Acyl-CoA Dehydrogenase

         complement(3981041..3981976) hypothetical protein Rv3542c"

         complement(3980655..3981044) hypothetical protein Rv3541c

         complement(3979495..3980655) sterol carrier protein

all 6 proteins overlap

CYP137   complement(4127292..4128722)

 

Mycobacterium leprae (11 P450s; 1 gene, 10 pseudogenes, M. leprae genome is decaying)

 

NC_002677 Mycobacterium leprae strain TN complete genome

 

CYP118P 547312..547788 locus_tag="ML0447"

CYP126A2P complement(1384839..1385327) locus_tag="ML1185

CYP139A2P complement(1474970..1475188) locus_tag="ML1237

CYP139A2P complement(1474991..1475161) locus_tag="ML1238

CYP143A2P 1861010..1862160 locus_tag="ML1542

CYP125A3P 2415021..2416227 locus_tag="ML2024

CYP164A1 complement(2481544..2482848) locus_tag="ML2088

CYP164A2P cosmid B1450 GenEMBL AL035159.1

CYP118P AGAIN DUPLICATION complement(2562932..2563627) locus_tag="ML2159

CYP138A2P complement(3167438..3168451) locus_tag="ML2648

CYP130A2P GenPept AL583920.1

CYP140A3P L01095.1

 

Other Mycobacterium species

 

Mycobacterium avium

CYP51

CYP140A4 paratuberculosis

CYP243A1

L76374 paratuberculosis partial

 

Mycobacterium abscessus

CYP136B1

 

Mycobacterium ulcerans

CYP140A2

 

Mycobacterium species AF107046

CYP150A1

 

Mycobacterium sp. strain RP1 AJ310142

CYP151A2

 

Streptomyces have about one third of all known bacterial P450s, but Mycobacterium smegmatis has the most in a single bacterial species. 

 

Streptomyces species (150 P450s)

 

Streptomyces avermitilis (33 P450s) by name order Actinobacteria

CYP102B2 SAV7426

CYP102D1 SAV575

CYP105D6 SAV412_pteD

CYP105D7 SAV7469

CYP105P1 SAV413_pteC

CYP105Q1 SAV1611

CYP105R1 SAV7186

CYP107F2 SAV1171

CYP107L2 SAV1987

CYP107P2 SAV4539

CYP107U2 SAV3536

CYP107V1 SAV3519

CYP107W1 SAV2894_olmB

CYP107X1 SAV6249

CYP107Y1 SAV2377

CYP125A2 SAV5841

CYP147B1 SAV584

CYP154A2 SAV109

CYP154B2 SAV3704

CYP154C2 SAV3882

CYP154D1 SAV1308

CYP157A2 SAV3881

CYP157C2 SAV6706

CYP158A3 SAV7130 fix name in data set

CYP170A2 SAV3031 fix name in data set

CYP171A1 SAV941_aveE

CYP178A1 SAV838

CYP179A1 SAV2061

CYP180A1 SAV2165_geoC

CYP181A1 SAV2385

CYP182A1 SAV2806

CYP183A1 SAV2999

CYP184A1 SAV5111

 

Streptomyces avermitilis (33 P450s) by chromosome order

CYP154A2 SAV109

CYP105D6 SAV412_pteD

CYP105P1 SAV413_pteC

CYP102D1 SAV575

CYP147B1 SAV584

CYP178A1 SAV838

CYP171A1 SAV941_aveE

CYP107F2 SAV1171

CYP154D1 SAV1308

CYP105Q1 SAV1611

CYP107L2 SAV1987

CYP179A1 SAV2061

CYP180A1 SAV2165_geoC

CYP107Y1 SAV2377

CYP181A1 SAV2385

CYP182A1 SAV2806

CYP107W1 SAV2894_olmB

CYP183A1 SAV2999

CYP170A2 SAV3031 fix name in data set

CYP107V1 SAV3519

CYP107U2 SAV3536

CYP154B2 SAV3704

CYP157A2 SAV3881

CYP154C2 SAV3882

CYP107P2 SAV4539

CYP184A1 SAV5111

CYP125A2 SAV5841

CYP107X1 SAV6249

CYP157C2 SAV6706

CYP158A3 SAV7130 fix name in data set

CYP105R1 SAV7186

CYP102B2 SAV7426

CYP105D7 SAV7469

 

Streptomyces coelicolor (18 P450S) Actinobacteria

 

Yellow and green blocks are genes in operons or very close together

 

159A1             625127..626350

157B1  complement(627628..628164)

       complement(628247..628588) putative ATP/GTP binding protein

       complement(821848..822048) putative ferredoxin

105D5  complement(822061..823299) 12 BP APART

102B1             847649..849232 no fusion

158A2           1278746..1279960 note PKS overlaps start, hypoth. overlaps stop

157C1 complement(1740065..1741561)

      complement(1741637..1742167) putative ATP/GTP binding protein

                  3137116..3137664 putative ATP/GTP binding protein

156A1             3137661..3138893 stop and start overlap

154A1             3138905..3140131 11bp between P450s

107U1 complement(3394340..3395641) hypothet. prot overlaps start

107P1 complement(4013901..4015136)

107T1            4143070..4144254

170A1            5682098..5683483

156B1            6970033..6971376

158A1 complement(7768860..7770083)

154C1 complement(8232555..8233778) P450 ENDS OVERLAP

157A1 complement(8233775..8235016)

      complement(8235013..8235564) putative ATP/GTP binding protein

155A1 complement(8258333..8259604)

105N1            8521684..8522919

 

Streptomyces peucetis (19 P450s)

CYP105F2

CYP105P2

CYP107L9

CYP107N3

CYP107P3

CYP107U2

CYP107AH1

CYP107AJ1

CYP125A4

CYP129A2 U77891 daunorubicin "doxA"

CYP131A1 L47164 dnrQ C-term has no heme signature

CYP147F1

CYP154A3

CYP157C4

CYP164B1

CYP166B1

CYP251A1

CYP252A1

CYP253A1

 

Other Streptomyces P450s not from whole genome sequences (97 P450s plus alleles)

with S. avermitilis S. peucetis and S. coelicolor = 150 P450s

 

CYP105A1 suaC Y18556.1 Streptomyces griseolus

CYP105A3 D30815 sca-2 Streptomyces carbophilus

CYP105B1 subC SU-2 M32239 Streptomyces griseolus

CYP105B2 Cyp229, Streptomyces tubercidicus strain R-922 78% to 105B1

CYP105C1 choP M31939 Streptomyces sp.

CYP105D1 P450soy X63601 Streptomyces griseus

CYP105D2 AF071145 Streptomyces griseus

CYP105D3 AF071149 Streptomyces sclerotialus

CYP105D4 AF072709  Streptomyces lividans 69% to 105D1 67% to 105D2 82% to 105D3

CYP105D8 Cyp233, Streptomyces tubercidicus strain I-1529 68% to 105D7

CYP105D9 Streptomyces sp. JP95 GenEMBL AF509565 11774..13024

CYP105F1 AF127374  Streptomyces lavendulae LinA homolog.

CYP105H1 AF263912  Streptomyces noursei ATCC 11455 nyst gene="nysN"

CYP105H2 Streptomyces albus GenEMBL AF071143 77% to 105H1

CYP105H3 Streptomyces natalensis GenEMBL AJ278573 52789..53985

CYP105H4 Streptomyces nodosus AF357202

CYP105H5 Streptomyces griseus AJ300302 canC

CYP105K1 Y18574.1 Streptomyces tendae strain Tue901 gene="nikF"

CYP105K2 Streptomyces ansochromogenes GenEMBL AF469953  14..1246

CYP105L1 AF147703  Streptomyces fradiae demethylmacroci gene=tylHI

CYP105M1 AF200819  Streptomyces clavuligerus clavulanic

CYP105N2 Streptomyces glaucescens cytochrome P450 GenEMBL AF071144

CYP105Q2 Streptomyces sp. GenEMBL BD133549 78% to CYP105Q1

CYP105Q3 Streptomyces sp. GenEMBL BD133546 77% to 105Q1

CYP105S1 Cyp230, Streptomyces tubercidicus strain R-922 new CYP105 subfamily

CYP105S2 Streptomyces tubercidicus strain I-1529

CYP105U1 Streptomyces hygroscopicus strain NRRL 3602 AY179507

CYP105V1 Streptomyces sp. HK803

CYP107A2 Streptomyces rochei plasmid pSLA2-L NC_004808 complement(44847..46067)

CYP107B2 Streptomyces sp. GenEMBL BD133548 58% to 107B1

CYP107C1 D30759 Streptomyces thermotolerans

CYP107D1 L37200 Streptomyces antibioticus

CYP107F1 AB018074  Streptomyces griseus CDS 341..1561

CYP107G1 rapN X86780 Streptomyces hygroscopicus

CYP107L1 AF087022  Streptomyces venezuelae cytochrome P. = pikC gene AF079139

CYP107L3 CypLA, Streptomyces tubercidicus strain I-1529 60% to 107L1

CYP107L4 CypLC, Streptomyces tubercidicus strain R-922 61% to 107L1

CYP107L5 Streptomyces sp. GenEMBL BD133547 68% to 107L2

CYP107L6 Streptomyces sp. GenEMBL BD133544 72% to 107L2

CYP107L7P Streptomyces narbonensis GenEMBL AF521878  13901..14661

CYP107L8 Streptomyces sp. HK803 AY354515

CYP107N1 AF127374  Streptomyces lavendulae LinA homolog

CYP107R1 AF254925  Streptomyces maritimus enterocin

CYP107Z1 Ema11, S. rimosus ssp. paromyceticus strain R-2374 96% to CYP107Z2v1

CYP107Z2v1 Ema8, S. albofaciens strain C-0083 96% to 107Z2v2 and CYP107Z1

CYP107Z2v2 Ema3, S. rimosus ssp. paromyceticus strain BOEH-4355

CYP107Z3 Ema7, Streptomyces sp. strain IHS-0435 76% to 107Z12

CYP107Z4 Ema16, S. lydicus strain NRAB-0114 82% to 107Z12

CYP107Z5v1 Ema15, S. lydicus strain NRRL-2433 97% to 107Z5v3

CYP107Z5v2 Ema6, S. chattanoogensis DSM-40241 1 aa diff to CYP107Z5v3

CYP107Z5v3 Ema4, S. lydicus strain R-401

CYP107Z5v3 Ema10, S. kasugaensis strain A/96 1 aa diff to CYP107Z5v2

CYP107Z6 Ema5, Streptomyces sp. strain I-1525 85% to CYP107Z8

CYP107Z7 Ema17, S. tubercidicus strain DSM-40261 90% to CYP107Z8

CYP107Z8 Ema13, S. platensis strain Tu-3077 89% to CYP107Z9

CYP107Z9 Ema12, S. tubercidicus strain NRAA-7027 89% to CYP107Z8

CYP107Z10 Ema2, S. tubercidicus strain I-1529 90% to CYP107Z11

CYP107Z10 Ema14, S. platensis strain I-1548

CYP107Z11 Ema9, S. platensis strain NRAA-7479 92% to 107Z12

CYP107Z12 Ema1, Streptomyces tubercidicus strain R-922 92% to CYP107Z11

CYP107AB1 Streptomyces rochei plasmid pSLA2-L NC_004808 Links 87725..88939

CYP107AC1 Streptomyces atroolivaceus GenEMBL AF484556 60948..62147

CYP107AD1 Streptomyces hygroscopicus GenEMBL AF521896 4248..5489

CYP107AE1 Streptomyces sp. GenEMBL BD133545 50% to 107X1

CYP107AF1 Streptomyces collinus AF293355 DSM2012 rubrinomycin gene cluster

CYP107AG1 Streptomyces atroolivaceus AF484556 leinamycin biosynthetic gene cluster

CYP113B1 U08223 Streptomyces fradiae

CYP113B2 Streptomyces caelestis GenEMBL AF016585

CYP113C1 Streptomyces virginiae GenEMBL AB072568 4994..6202

CYP122A1 U65940 Streptomyces sp.

CYP122A2 rapJ X86780 Streptomyces hygroscopicus

CYP122A3 AF235504  Streptomyces hygroscopicus var. gene="fkbD"

CYP124B1 Streptomyces cinnamonensis GenEMBL AF440781 93981..95273

CYP124B2 Streptomyces nanchangensis NS3226 AF521085 complement(100196..101467)

CYP129A1 U50973 doxA Streptomyces sp.

CYP131A2 L35154 Streptomyces sp. dauQ N-terminal

CYP147C1 CypEA, Streptomyces tubercidicus strain I-1529 new subfamily CYP147C1

CYP154B1 AF145049  Streptomyces fradiae tylosin-biosynt.

CYP154J1 Streptomyces carzinostaticus subsp. Neocarzinostaticus GenEMBL AY117439

CYP154K1 Streptomyces rochei NC_004808 complement(144081..145325)

CYP157B2 Streptomyces hygroscopicus subsp. Yingchengensis AY260760

CYP157C3 Streptomyces griseus GenEMBL AB044803 3754..5328

CYP159A2 Streptomyces hygroscopicus Yingchengensis GenEMBL AY260760 983..2209

CYP160A1 AF127374 Streptomyces lavendulae LinA homolog

CYP161A1 AF263912 Streptomyces noursei ATCC 11455 nyst gene="nysL"

CYP161A2 Streptomyces natalensis GenEMBL AJ278573 81418..82611

CYP161A3 Streptomyces nodosus AF357202 amphotericin biosynthetic gene cluster CYP162A1 AJ250199 Streptomyces tendae nikkomycin gene="nikQ"

CYP163A1 AF170880 Streptomyces spheroides novobiocin gene="novI"

CYP163A2 Streptomyces roseochromogenes subsp. Oscitans AF329398 15196..16419

CYP163A3 Streptomyces antibioticus GenEMBL AF322256 22228..23478

CYP165A4 Streptomcyes toyocaensis AF039028 complement(11438..12613)

CYP165B5 Streptomyces lavendulae GenEMBL AF386507 42222..43493

CYP165C5 Streptomcyes toyocaensis strain NRRL 15009 GenEMBL U82965 AF039028

CYP165D1 Streptomcyes toyocaensis U82965 AF039028 complement(10263..11417)

CYP165E1 Streptomyces lavendulae GenEMBL AF386507 41015..42208

CYP171A2 Streptomyces nanchangensis GenEMBL AY129009

CYP185A1 CypLB, Streptomyces tubercidicus strain I-1529 new family

CYP208A1 Streptomyces globisporus GenPept AAL06697 

CYP208A2 Streptomyces carzinostaticus subsp. Neocarzinostaticus GenEMBL AY117439

CYP211A1 Streptomyces globisporus GenEMBL AY048670

CYP235A1 Streptomyces antibioticus GenEMBL AJ002638 184..1389

CYP244A1 Streptomyces sp. TP-A0274 GenEMBL AB088119 complement(5410..6594)

CYP245A1 Streptomyces sp. TP-A0274 AB088119 13260..14513

CYP246A1 Streptomyces acidiscabies GenEMBL AF393159 537..1724

 

Thermobifida fusca Streptomycetes? (10 P450s)

 

CYP154E1

CYP154F1

CYP154G1

CYP154H1

CYP157A3

CYP215A1

CYP216A1

CYP217A1

CYP218A1

CYP222A1

 

The genus Amycolatopsis Arabobacteria (16 P450s)

 

Amycolatopsis mediterranei

CYP105G1

CYP105J1

CYP107Q1

CYP107Q2

CYP165A1

CYP165B1

CYP165C1

CYP166A1

 

Amycolatopsis orientalis

CYP146

CYP165A2

CYP165A3

CYP165B2

CYP165B3

CYP165C2

CYP165C3

CYP165C4

 

The genus Actinomadura Streptomycetes? (7 P450s)

 

CYP107M1 Actinomadura hibisca

CYP165A5 Actinomadura sp. ATCC 39727 AJ561198

CYP165B2 Actinomadura sp. ATCC 39727 AJ561198

CYP165C6 Actinomadura sp. ATCC 39727 AJ561198

CYP165D2 Actinomadura sp. ATCC 39727 AJ561198

CYP208A3 Actinomadura madurae

CYP247A1 Actinomadura verrucosospora

 

The genus Micromonospora Arabobacteria (5 P450s)

CYP105L2 Micromonospora griseorubida

CYP105W1 Micromonospora