Honeybee Cytochrome P450 Sequences
48 Honeybee P450 protein sequences plus 13 fragments, revised Sept 27, 2005-09-22 edited by Reed Johnson, Rene Feyereisen and David Nelson
CYP2 clan CYP15, CYP18, CYP303, CYP304, CYP305, CYP306,
CYP307, CYP342 (name changed to CYP369A1), CYP343 (note CYP304 is not found in honeybee)
>CYP15A1
MLYVVISLLLALYCIFCIYDCVKPHNFPP (1)
GPKWLPLIGCFLTFRRLKLKHKYTYVAFQELSKTYGPILGLKLGSQKLVVISTHDLVKKVL
LQDEFNGRPDGFFFRVRAFGKRK (1)
GILFTEGSMWSQCRRFTMRHLRSFGLGQSTMEKYLTVEAENLVNYLRRVSTKGPVPMHTAF
DIAVLNSLWCMFAGHRFDYENEKLAEILEIVHDSFR (2)
LMDTMGGIISQMPFLRFIIPELSGYNNLMEILRKLWNFLDEEINNHEKHLSGNQPQDLIEA
FLLEISSRNGVQNDSIFDR (1)
ENLLILCLDLFLAGSKTTTDTLSTSILFLSLHSEWIKILQEELDNVVGRSRSPTLEDYSSL
PIMESFLAE (0)
IQRFLILAPLGVPHKTTKDVILNGYNIPK (0)
DTTVLLDFHSAHNDPAYWDHPEEFRPQRFLDANGRFCQNNANIPFGL (1)
GKRRCPGEMLARTSLFLYFAYVIHYFDIEISPEHGKPDLNGHDGFTISPKSYYLKITARSD
VTNCSTI*
>CYP18A1
MLVEHAAQWAWQAMGGTRIEVLCTFLVFLGVLLVARCLQWLRYVRSLPPGPWGVPVFGYLP
FLKGDVHLRYGELAKKYGPMFSARLGTQLVVVLSDHRTIRDTFRREEFTGRPHTEFINILG
GY (1)
GIINTEGAMWKDQRKFLHDKLRGFGMTYMGGGKKIMESRIM (0)
REVKTFLRGLASKRGTPTDVSASLGMSISNVICSIIMGVRFQHGDARFKRFMDLIEEGFKL
FGSMAAVNFIPVMRYLPCLQKVRNKLAENRAEMAGFFQETVDQHRATFDEGTMRDLVDAYL
LEIEKAKGEGRATTLFQGKNH (1)
DRQMQQILGDLFSAGMETVKTTLEWAIILMLHHPDAAIAVQEELDQVVGKSRMPVLEDLPF
LPITEATILEVLRRSSVVPLGTTHATTR (2)
DVTLHGYTIPAGSQVVPLLHAVHMDPELWEKPEEFRPSRFLSAEGKVQKPEYFMPFGVGRR
MCLGDVLARMELFLFFSSLMHTFELRSPQGSSLPSLRGNAGVTVTPDPFDVCLLPRNLDLI
EDNDMISTGAILRNIGSH*
>CYP303A1 hybrid seq
from parts not joined in genome assembly
MFSMVILCIVLLLLLLYLGLQKPKGYPPG
(1)
XXXXXIIGSRLRILSFTLQNHYLFKTFSVLSKKYGPIIGMKIGINHVVVLNEYESIK
SMLSNEDCDGRPFGILYDKRTGGINR (1)
GLLLVDGNLWNEQRRFVLKHLRDFGFGRQSMMSIIIEE (1)
NLYMNANEYTGNNVTQSQLGTIISMHNIFGITVLNSLWKMLAGKR(2)
YNIDDKELIYFQRILSITLNEIDMLGAPFSHFPLLRFIAPEISGYKSFVKIHEELWKFFK (0)
DEVNNHKNTFNSDSPGNLIDIYLTILNSENYGKTFS (1)
EPQLVAICVDLFMAGSETTSKVLGFCFLYLVLFPHVQKKAHEEIDRVIGRNKLPTAEDKAK (2)
MTYMNAIVLESLRMFAGRSLNLPHRVQRDTKISDYKIPK(0)
NTIIITNFNGILMDESWGDPENFRPERFIDGSGNIVTPSRFLPFSA (1)
GKHRCMGENLAKTNIFIIATTLLQAFTFSEIPGEKPTIEHFIDGTTISPKPYRVNVSLRI*
>CYP305D1
MFVIMLIVILILTIIFIKIEKNTKLYPP (1)
GPFSWPFIGNQILLKRLSRKFGGQHKAFMELSKRYNSDIITVNISYEKIIVVSGSKFCDMI
LQNEEFQGRPWNEFIKVRNMGKKQ (1)
GITMNDGTEWKELRNWMMRTMKIFGFGKSEMIEMIQHQLVIFSENLNKNKLHQLKLLFVPA
VINVLWNFITGELVAFNQQQK (2)
LEHFLDLLDRRSRCFDITGGLLAAFPWIRYIAPEISGYNIMCMLNKELKDFLM (0)
KTINDHKEKYIEGKEADLIDMFIQEMRKNEKSSIFT (1)
DEQLMMILIDLFLAGFTTTSTTLDFLFLIVTLFPDVQRKVQKEIDSVIPYDRLPNMEDKAK (2)
LPYVEAVISETYRLWPVFPIIGPRRVLCDTNIDKYVIPKDTTILFNTYSINKDPTLYPDPD
KFMPERFIKNGVFEPDEYSLQFGK (1)
GKRRCPGDILAKATIFILFVGIMQKYTLLPVPGKGPHSIKINSGITLTPQPYNVLVEKR*
>CYP306A1
MILDHYIAIFVLPFLLLLYVVRKNRKARRLPPGPWQLPLLGYLPWIDAEKPHETLTRLSRV
YGPVCGFRMGSVYTVLLSDPQLIRQSFAKDSITNRAPLYLTHGIMKGY (1)
GIICAEGEQWKDQRKFISNCLRNFGMVKHEGAKRDKMEERISDAVNECVS (0)
VLRDRGANGPIDPLDTLHHCLGNLVNSIVFGKTYEEEDRIWKWLRHLQEEGVKQIGVAGPL
NFLPFLR (2)
FLPQYGRVIRSIVDGKDKTHEIYRQILDEHRARVDSGNGCKIDSFLAAFDEQMRKKDGAES
GYFTEPQLYHLLADLFGAGTDTTLTTLRWFLLFMAAHPMEQ (0)
EKIQSEMDLCLREGEQPTLNDRIVMPRLEAAIAEVQRIRSVTPLGIPHGTSE (0)
DVEIGGYDIPCGAMIVPMQWAIHTDPAYWRDPLEFRPDRFLSEDGTFFKPESFLPFQN (1)
GKRVCVGEELARMILFLFAGRILRAFSVRVPAGEIADLEGECGITLVPKPHRLAFVGRDR*
>CYP307B1
MIPLTATTCFLIAITFLALALILLDHLRSKKTTKSVVPGDDDQHALPEPPGPKPWPILGSL
HILGRYDVPYKAFADLVRDFDCQVIKLRMGSVPCVVVNGLENIKEVLTVKGHHFDSRPNFA
RYHLLFGGNKEN (1)
SLAFCNWSDVQKARREMLRAHTFPRAFSTRFNELNGIIGDEMEFMVNHLDSLSGTSVHAKP
LILHCCANIFITYLCSKNFHLEHDGFRNMVENFDKVFFEVNQGYAADFLPFLMPLHHRNMA
RMAHWSHEIRRFVIKNIIADRVNSWNDVVPEKDYVDCLINHVKSGTEPQMSWNTALFVMED
IIGGHTAIGNLLVKVLGFLATRPEIQRLAQDEIDALGLAGNFVGLENRRSLPYVEAIILET
IRIIASPIVPHVANQDSSIA (1)
GFRIKKDTFIFLNNYDLNMSTDLWTSPEEFMPDRFVQNGRLLKPEHFLPFGGGRRSCMGYK
LVQYVSFAILASILKNFTITPVQKEDYTIPIGNLALPEMTYKFRFERR*
>CYP342A1X name changes to CYP369A1 due to a naming conflict with a Nereis sequence.
MISFLFIIFLLLIIYKIYNSVIHVSSNTPPC(1) LPRLPIIGSYWHLLWHDYEYPYNGIIHYVNKLQSKIVTCYFGSHKTIIANDYKSIKEVLTK
QEFNGRPINVDIVLQRAFGKSL (1)
GIFFTEGTLWHEQRRFALRHMRDFGFGRRHEIFETNVMEEIAILVDMLKEGPINDEEK (0)
KFLKNGYACFPDILYPYVANVILNIMFGERFDRSQYHKLIYFCESSMMFQKSLDTSGGAIF
QFWFLKYFGNIFGYTNAIKATYQMINFIE (0)
EYIDNKKDLDDYDKGLIGRYLKILKEKNNITSTFSQKQLIMTLVDFMFPATSALPSALVHA
IKLVMHHPRVVNNIQEEIDRVVGTGRLVTWSDRKN (2)
LPYIEATIRESLRYETLTPLSVFHKTLKKTTLCDYDIPKDTLVVTNLVALNTDPDLWGDPE
NFRPERFLDENNELRKDFTFPFGF (1)
GHRVCPGETYSRYNMFEVFAVLMQNFNFSFVEGEPTGLDDKESGLIVTPKKTWIQVKARNMK*
>CYP343A1
MWFVILCFVIVLIKILFDYSRPINFPP (1)
GPRGLPFIGNILDIIKLINETKYYSDTWCRLAEKYGSVVGLRLGLDQPLIIVSGKSAVTEM
LNRSEFDGRPSGFLYKYRCGGMQQGILFTDTDVWHSQRR (2)
FALKTLKQFGFGKNSMEHILQHDAIALTNIIIELTKDGTVKNIRSIISAAVLSNLWLLIDGTK (2)
FDIGMENSNLKEAINIVQDIVKSSNVSGGIINQFPFLRHLFPNLTGFSAFVERQKRINNFFM (0)
EVIAKHKWKKINEEGTNFIDVYLQEIQKKNSSHSFFN (1)
ENQLLYIIKDLFSAGVDTTNSTIGFIIAFLVVHQDVQSKVYDEISRVIDKDIYPSLSDKDR (2)
LPYLKAVIAEVSRLANIGPTSIPHRAVKDSTFLGFEIKKNYTLLANFKSIHMDKEHWGDPE
IFRPERFINEKGDFINDSWLMPFGL (1)
GRRKCLGETLAKNTVFLFVACMLQRLHFMLPSNHPPPCLQGIDGFVIAPPMMDIIAVQRF*
CYP4 clan CYP4G11, CYP4AV1, CYP4AB3, CYP4AA1
Note: CYP4 clan extremely reduced compared to flies and mosquitos
>CYP4G11
MAAASATGFSASSVFLSLLIPALILYFIYFRISRRHLLELAEKIPGPPALPLIGNALDLFGSPD (1)
AMFSQVLKKAENFKDVVKIWVGPKLVICLIDPRDVEIILSSNVYIDKSTEYRFFKPWLGDGLLIST (1)
GQKWRNHRKLIAPTFHLNVLKSFIDLFNANARSVVEKMRKENGKEFDCHNYMSELTVDILL
ETAMGVSKPTRDHNAFEYAMAVMK (2)
MCDILHLRHTKIWLRPDWLFNLTKYGKNQIKLLEIIHGLTKKVIQLKKEEYKSGKRNIIDN
SAQKTESK (0)
TNNIVVEGVSFGQSVGLKDDLDIDDDVGEKKRQAFLDLLIEAGQNGVLLTDKEVKEQVDTIMFE (0)
GHDTTASGSSFFLAVMGCHPDIQEKVIQELDEIFGDSDRPATFQDTLEMKYLERCLLETLR
MYPPVPLIAREIKTDLKL (1)
ASGDYTIPAGCTVVIGTFKLHRQPHIYPNPDVFDPDNFLPEKTANRHYYAFVPFSAGPRSC
VGRKYAMLKLKIVLSTILRNFRVRSDVKESEFRLQADIILKRADGFKIRLEPRKQVASTA*
>CYP4AV1
MSSSTIIMGVSWLTMILSICLMTIVVLLLVRRGKFLYALRKVPCPPAFPIIGNAYELCCSPE (1)
EAFKKMIKWGKELGDMYLIWVGMRPFIFLYKAEAIQPLLSSSVHIDKSLEYQYLQPWLGSGLVTST (1)
GEKWHFHRKLLTPTFHSGLLELYLKTTIREAQILISCLRKEIGKPEFDIVPYAKRAALDIIC (1)
DSSMGCNINAQKNFENEYVQAVNT (2)
LASISQRRFLNVWMSFDPIFKLTSWGKRHDHALSVTHGFVNK (0)
IIAERKAEWKDRKDTNFNEKSHKRQALLDLLLELSKDGKVLTDDDIRDEVNTFMFAGHDTT
ATSVSWILYALGRHPQYQ (0)
ELIIEEYDETVGTKELTLDILSKLTWLEACIKESWRLYPVTPLIARQIYHPITIL (1)
GHEIPIGSTVLVNSFLLHRDSRYFPEPDIYRPERFLPDGPKYPSYAFVPFSAGSRNCIGWK
YGTMIVKVLILYILKNFHVESLDTEDQLRFISELVLHNADGLRLKITPRK*
>CYP4AB3 revised to add 27 amino acids at N-term
name changed from 4AZ1 since wasp has a large clade
of 23 CYP4AB genes and 4AZ1 belongs with this group
MISAILFFIFLLATLHYFLLHHRKFGKMINLIPGPEPLPILGNIPTFHNISP
(1)
SELWKFLTQLSKQYYPIYRMWTFLEAYVHICHPDDIE (0)
TILGNIKFTKKGFGYKYLKPWFNTGLLTSS (1)
GHKWHVRRKILTSAFHFNVLRQFVDIFIEDAERLIKTLESEEGIFVENLLQLTSEHTLNVIC (1)
ETAMGTSLKNKEKFQYEYRKAVYNMGCIFANR(2)
IVKPWFYYDFFFNLSPEGWQQSKLLKILHNFTRK(0)
IIQERKEYHDKTNGRYLNDFHENINENDNNNDYND(1)
FRRKRLAMLDLLIEAHRNNKIDDEGIREEVDTFMFR(0)
GHDTTAISFCFSIMLLAEHKEIQ(0)
DRARAEIKAAIEENGGKLNITVLQNLPYLERCIKESLRLFPSVPRISRKLETSVKL (1)
SNYEIPSNTIINVNIFDTHRDPKFWPNPNKFDPDRFLPENSKKRHPYAYVPFSAGPRNCI (1)
GQRFAMLELKTYLGLLLYNYYFEPIDYLKDVTFVSGIVLRLENPVRMKFIPVKKIC*
>CYP4AA1 name changed from CYP4BA1 (ortholog)
hybrid seq from parts not joined in genome assembly
MGKVSSSLTSIYILYILRTYIRSIIYISQLNGPKTIPIIGNANSILKEN
(1)
FLYRLAYESQMYGRIVRIWLTIFPYVMFLEPEDIQLILNNAKHTQKVFFYKLLDNFLGKGL
ITRDIKSWRIHRRLLQPAFHLHVLEKFTNTFAKHADHLMNKILEKNNQEINITTFINDSVYNILS
(1)
ETVLGINRINRINEMDDLPFRK
(2)
GQIMLLYRMIRPWLLIEWIYRLTKYGREEEKQRKNLFDTCFKMVKEKRDLLQSKDRISNNDIKKNKNISLLEYMVEINEKNPCFSDEDIVEECCTFMLAGQDSVGTATAMTIFLLANHPEWQNKCIEEIDEIFNGDTRFPTISDLKEMKCLEMCIKESLRLYPSVPIIGRTLGEDIKI (1)
GKHIIPAGCSVLISPYSTHHLPHHFPDPDTFKPERFNSENSEKRHPYAYIPFSAGPRNCI (1)
GYKFAMLEMKSIISAILRKCRLQSIPGKKEIRPKFRMTIRAQGGLWVKIIERDQILKSIAA*
CYP3 clan CYP6, CYP9 CYP336
>CYP6AQ1
MNLLTPYWSLDILIVSSSLMIAVYLYASWKLKYWSRRGIMQITPSPLFGNFKKCILFQKSV
SEIIRELYGQNEGLPFMGFYIFYKPFFLVRDIELVKHILVKDFNTFANKHTSADSKNDRIG
YSNLFIIKNPAWKYLRGKLTSVFTSGKLKKMFDLMLIIGKNLEKHLELLNLD (1)
GNGKEVELKDLCANFTTDLIGTTAFGVNLNSLKDPNSDFRENGRLVFDYNLKRAFEFFSIF
FFPNLSKYVSIKFFGKATDYFRNSFWSVINQRIESNVKRNDLIDCLIELREKHKNDESFEGF (1)
RFDGDDLVSQAAIFFTGGFETSSTTISFTLYELALNKDIQKTVRTEIHEALAQTDGKITYDM(0)
ITNLPYLDMVVSETLRKYPPLGFLDRVALHDYKIPNSDVTIDKDTPVIIPMIAFHYDPKYF
PNPEKYDPLRFSEEVKKTRPSYVYMPFGEGPHICI (1)
GMRLGLLQSKLGIIEILKDYEVSPCEKTKIPMVLDPKGLTTTALGGLYLNIRKITIAAG*
>CYP6AR1
MIETVGLIATVFFLLYYYSMSKLDYWRKRGVKGPKPLPFLGNFKDVLLAKESTMDCFERAY
KEFKDEPMVGMYGSHEPLLILRDLDLIKDVLIKDFNKFAQRTQGAIRE (0)
VEPLSEQLFRLDAERWRPLRLKLSSFFSSGKLKEMFHLFVECSDNFEKYLEKMVEKGGLVE
CRDAAAKFSTDVIGACAFSIHTNALTDENSQFRKMGKQALATNLQQFLNDRLREYPFLFKI
FGRFFVDHEVTNFFANSIKDAMDYRIQNNVHLRDVIDILADIRENPTKCGLK (1)
EADNLFLTSQAVLFFLAGFENASLTISNALYELAWKPEIQEKARAEIVNVLQKYDGKITYD
GLEEMKYLEACIF (1)
ETLRMYPVLQWLSREAMETYTFTGTKVTIPKGQQVFLPIYAIQRDPDIYPNPDNFDPERFT
DDKIKTRHSMTHLPFGDGPRHCS (1)
GIRLAKKQLKVGLVTVLSKFKVEVCEKTRKIYQKDKKPLFLLQPVDGIHLKISKVSV*
>CYP6AS1
MDYFQILCAISIVILTIYYYYSSKYTFWKKRGISGPKPIIFFGNFVDSIIQKRSTSEAVKK
WYDDYKHESVFGIFGGTTPLLVINDLDMIKDVLIRDFSLFVDRGFHIFPK (0)
IEPLSEHLFLLEAERWRPMRMKLSPIFTSGKLKEMFFLIMESAGNLEKYLDEVIKKDEMVE
CRELAAKFMTDVIGSCAFGINTNSLLEEDSEFRRMGKKISTPNLKVMLGNICKEFFPPLYE
IVGSIFTLKDVNEFFINLVSDTMKYRKDNNIIRSDFINMLMQLKEHPEKMENI (1)
ELTNTLLTAQAVVFFVAGFETSSSTMAFSLYELAQNQEIQDKLREEIRNMHEKNKGVLTYT
DVKEMKYLDKVFK (1)
ETLRKYPILPMLFRQAMENYTFKDTKITIPKGMKLWVPVHGIHHDPNIYPEPEVFDPERFE
DDAFASRHPMSYLPFGDGPRNCI (1)
GARFAHYQSKVGLITILRHHKVNVCEKTTIPFKADERSFLLTLKGGVHLKITKI*
>CYP6AS2
MDYFQILCAISIVILTIYYYYSLKYAFWKDRGISGPKPIIFFGNFGNSIIKKKSLSETVKK
WYDDYKHESVFGIFEGTIPVLVINDLDMIKDILIRDFSLFVDRGFHIFPK (0)
IEPLTQHLFLLEAERWRPMRMKLSPIFTSGKLKEMFSLIVESAGNLEKYLDEVIKKNEMVE
CRDLAAKFTTDVIGSCAFGINTNSLLEEDSEFRRMGKKIFSPSLKLMIGNTCKVFFPSLYE
VIGNIFTMKDVDEFFINLVSDTMKYRKDNDIVRSDFINMLMQLKEHPEKMDNI (1)
ELTDTLLTAQAVVFFIAGFETSSSTIAFGLYELAQNQEIQDKLREEIRKMHEKNKGILTYT
DIKEMKYLDKVFK (1)
ETLRKYPILSTLSRKAMENYTFKGTKITIPKGTKVWVPVYGIQHDPNIYPKPEVFDPERFE
DDAFASRHPMSYLPFGDGPRNCI (1)
GARFAHYQSKVGLITILRNHKVNVCEKTTIPFKADERSFLLALKGGVHLKITKI*
>CYP6AS3
MDYFQLLCVIGALLFAIYYYLTLTFDTWKNRGIPGPKPTIFFGNFQEVILKKISLAEKTKQ
LYQEYKNELVFGIFQGRTPILVINDLEMIKDVLIRDFSVFPDRGIHVNPK (0)
VEPIFQTLFSLKSKTWRPLRMKLSPVFTSGKLKDMFPLILDCAKNLEEFVEKVRNSGEPVD
CRDMAAKFTTDVIGSCAFGVCMNSLSPEGSEFRRMGEQLGKFSFKKLARDFTRLYMPFLFD
IIGGYLQSHEVNNFFINLIRDSIKYRQENNVYRPDFVNTLKELKEHPEKLENI (1)
ELTDALLTSQALVFFLAGFETSSTTISNALYELAQNPEMQDKLRKEIKEVYENNGGALSYT
DVKEMKYLDKVFK (1)
ETLRKYPVLAALSRQATENYTFKDTKIKISKGTRIWIPVYGIQHDPNIYPEPEVFDPERFE
DDAFASRHPMTYLPFGDGPRNCI (1)
GARFAHYQSKVGLITILRNNKVEVCAKTLIPYKSEPRNILMIPKGGKVELRITKV*
>CYP6AS4
MLHHFHILTAFVAIFLALYYYLTSKFDFWKNRGVSGPRPVPFFGNAKDVLLRKIGIGSFIA
ELYKRYDNEAMFGIFIGRSPNLVLRDLDLIKDVLIKDFSIFDNRGLNIPER (0)
AEPFSVNLFSVDATRWRPLRMRLSPVFTSGKLKEMFPLILECAEHLEQCLEDAVKRGGPVD
CFEIPARYTTDVIGSCAFGINMNALSDERSEFRKMGRNMFDQNMIKFTRNLLRDFFPRFYN
LLGFVLPYTESTVFMTKLIKGTIKYREENDVVRPDFVNLLMELKKHPEKLKNI (1)
EITDTLLAAQASVFFAAGFETSSTTMAHALYEMALNPDIQDKLRNEMKEFHAKNNGNLKYE
DIKEMKYLDKVFR (1)
ETLRKYPPGMLLRRKCNSNYTFHGTKVSIPAGTSVIIPLYAIQIDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRNCV (1)
GARFAVYQTKVGLIKILQNFRVDVCEKTMIPYVKKINSITLAPRDGIFLKIEKITD*
>CYP6AS5
MASSFEILCGIAVLFLALYYYLTSTFDFWKSRGVVGPKPVPFFGTTKDLILVKKSTAHFVK
DIYEKYKNEPMVGLYATRSPFLLLNDPELIKDILIRDFSKFANRGLGVFER (0)
TEPLSPHLLNLEVERWRPLRSRLSPIFTSGKLKEMFYLIIECSLNLEMYLDKLIEKNEPIE
CRELTARFTTDVIGSCAFGIDMSSMTNENSEFRRMGREVFAVNFMNVMRMKLKQFMPRLYD
LLGYVMPDRTFAPFFTRVVTDTIKYRNDNNIVRPDFINMLMELQKNPQKLENI (1)
KLTDSLIAAQAFVFFLAGFETSSTTMSNALYELALNQDVQKKLREEINTFCPKNNKELKYD
DIKEMEYLDKVFK (1)
ETLRMYPPASILMRKAISDYTFNDTKITIPKEMKIWIPAFAIHRDSAIYPNPDSFDPERFD
KDAMASRHPMHYLPFGDGPRNCI (1)
GARFAVYQTKVGLITILRNHKVEVCEKTVIPYEFDPGAFLLSPKDGIYLKITKI*
>CYP6AS7
MPSLEIIFGIILLFPAIYYYFTSTFDFWKVRGVPGPKPIPIFGNIKNVMLLKTSMCHYLKK
LCEEYKHEPMIGIFTRKTPILIIQDPDLIKDVLIRDFSKFANRGIPIHEK (0)
AEPLSPHLFNLEVERWRPLRTRLSPVFTSGKLKEMFPLILDCAKHLEQYLDKLVLREEFIE
CRELTAKYTTDVIGSCAFGIEMNALSDEESEFRRIGRKVFSNSFGQILRFRFRQIFPRIYN
LLGFVLPPMEVTKFLTNIIVSTMKYRQENNIVRPDFVNMLIELKKHPDKLENI (1)
KLTDTLLTAQAFVFFIAGFETSSSAISNALYELALNPEVQNKLRQEIKEYFNKHNELKYEY
IKNMIYLDLVFR (1)
ETLRKYPPGPLILRKSITNYTFNNTKVSIPEESFVWIPLYAIHHDPKIYPNPDAFIPERFN
DDAIATRHPMHYLPFGDGPRNCI (1)
GARFAVYQSKIGLITILWNYKVEVCDKTMIPYEINPAAFLLTPKGGIYLKFTKIKNNEEILN*
>CYP6AS8
MYISLEIFCGIVVALIALYYYLTVNNNFWKNRGIAGPEPVLGFGNMKKVLLGKESMSQFLT
KIYHEYKNEPIIGIFTTRTPQLIIKDPDLIKTILIKDFSKIMNRGLLPMVS (0)
GEPISQHLFNIEAERWRPLRIHLTPVFTANKLRGMFSLILECSMHFVSYVDSLVKKGEPVN
VREVAARFTTDVVGSCGFGVEMNSLSEKESEFRRVGKSVFATNYARIIKHRIREFMPRLYN
YILYLWPTDEMAEKIIKLTRETLEYREKNNLFRPDFMNILLDLKKHPEKIGL (1)
DVTNEFLAAQAFIFFVAGFETSSSTISNALYELALNPDVQDKLRKEIKEFAAKNDGEWRYE
TIKEMEYLGKVFQ (1)
ETLRKYPSLPFLTRELIEDYTFESNKVTIPKGLKIWIPTYAIHNDPDIYPDPDKFDPERFS
DDKIKQRHPMHFLPFGHGPRNCI (1)
GARFAIYQTKIGLINILRNFKLDVCDKTLIPYKHHPRGLLLMPLTDLYLKITRLTN*
>CYP6AS9P PSEUDOGENE? GC boundary at CIG, IFGG = IFQE in v1.2
MFINLETLCGFVIVLIAFYYYLTINNNFWKNRGIPGPKPTIGFGNMWTVMFGKESFSQLLT
TIYNKYKDEPMIGIFFRRRPVLLLKDFDLIKDVLIKDFSKFANRGFLKTNP
(0)
KVPLTNHLFALEVKRWRPLRNHLXSPVFTSGKLKGTFAQILNCSNDLVTHIDTLSKMEDSI
NMREVAAKFTTDVIGSCVFGIKMNSLSEIENEFRRIGRNIFATNFTNILKIRLLQSTPFLH
SLLCKILPDEEMEMFMRITKETMEYREKNNLVRPDFMNILLELKKHPERIADI
(1)
ELTDDLLAAQAYIFFAAGFETSSTTISNALYELALNHDMQDKLREEIKEFEAKNDGEWRYE
TIKEMQYLGKIFG
(9)
GTLRKYPALSFLSRESIIDDYTFRDTKLTISKGTLVWIPVFPIHHDPNIYPDPEKFDPERF
TEDKIKERNLMHYFPFGHGPRNCI
(1)
GARFAIYQTKIGLIKILRNYKVDVCSKTLIPYKYDPFSFILVPLGGLYLKITRI*
>CYP6AS10
MAAFEILCGFIIFIFAFYYYLIKPQEYWKNRGVPGPKPIPIFGNFFRLTFARISIGDLMTK
FYKEYKHEPVFGLYMRNVRVLAINNPDLIKTVLIKDFSKFAHRGLALNEV (0)
TEPLSQHLFVLEPKRWRPLRTKLSPIFTSGKLKDMFSLIIECSNTLENYVEHLISKNDRVE
VRDLAAKFTTDVIGSCGFGVDMNAMSDVQCKFRDIGREFFGPSFKQILKIRLRENLPRLYT
FLGYILPRDETTTFFTNVVLDMIKYRKTNDIYRPDFINALINIQNHPEKLDI (1)
ELTEPLLVAQAFLFFVAGFETSSLTIATALYELAQNQDIQDKLRDEITEHHKLNNGEWQYE
NIKNMPYLDAVFK (1)
ETLRKYVPLTVLMRQSLEDYTFESINLTIPKDTRIFIPIYAIHRDPDIYPNPEVFDINRFS
KEAEATRHPMHYLPFGDGPRNCI (1)
GARFAIFQTKIGLIKILRTYKVDVCNETQIPFINEPRTFTLAPKHDLTLKITKIEN*
>CYP6AS11
MYINLEIFCAIVIAFIAFYYYLTINNNFWKHRGISGPKPVLGFGNMKKIILGEESMSQYLT
KLYHKYKNESMIGIFRLRTPALIIKDPDLIKIVLIKDFSKFMNRGLLPIIS (0)
TEPISHHLFALEAERWHPLRKHLTSGFTSNKLKGMFCMIHECSKHLVNYLDILVRKEEPVN
VREVAARFTTDVVGSCGFGVEMNSLSEQESEFRRLGKSIFNTNVQKIIKDRIRELTPQVYN
FLLYILPLDGISPKILKLMKETIKYRKKYDIFRPDFMNIILELKKHPEKINI (1)
DITNELLAAQIFIFFAAGFETSSTLISNALYELALNPNIQDKLREEIKKFESQNDEEWKYE
TIKKMDYLEKVIQ (1)
ETLRKYPPVPFLNRELIDDYTFESNKVTIPKGLKIWIPTYAIHNDPDIYPDPDKFDPERFS
EDNIKQRHPMHFLPFGHGPRNCI (1)
GIRFAEYQTKIGLINILRNFKLDVCDKTLIPYKLHPRGLILIPLTDLYLKITRLTN*
>CYP6AS12
MAYIEILCGIIVSMLVFYYYFTSVFNFWKIRGIPGPKPKFLFGNIRDIILSRISTPTFIKN
IYDTYTNEPMVGLYMGRNPILLLKDPELIKDVLIRDFSKFADRGFNVHEK (0)
VEPLSQHLFNLEPKRWRPLRSKLSPMFTSKKLKEMFGLILECGHHFEKYVDGLAARRQPVD
FCEVAAKYTTDVIGSCAFGINMNAMSSEGSEFREAGRKIFEPTWNSIIRLKFKITMPTLYD
LLGPLVPEREVTPFFIKVVTDAMKYRKERNVFRPDFIDTLMKLRDDPESLSDI (1)
ELTDAFLTAQAYVFFAAGFETGASTISNTLYELAQNQGMQDRLREEIREHCDKYGGELMYE
NIKEMEYLDKVFK (1)
ETLRKYPPGTLIPRRSVSEYTFKNTNVTIPKGTMIWIPAFPIHRDPNIYPNPDDFNPENFT
EDAINNRHPMNYLAFSNGPRNCI (1)
GARFANYQVKIGLIMILRNYKVEVCEKTVIPYQFDPNLFLLGPKGGIYLRVTKVE*
>CYP6AS13
MDFFQIFCAICIMLLAIYYYYTSIYNYWKVRGIPGPEPTIIIGNFMEVFLKKISINDKLRF
LYNKYKNEPMFGIFEGSSPILVLNDLDLIKDVLIKDFSIFSNRGFRIFPK (0)
AEPLGEHLFALETERWRPMRAKLSPIFTSGKLKEMFPLIIECSKNMEPYLDKIAERGKYIE
CRDLAAKFTTDVIGSCAFGIDMNSISDKDSEFRIIGRKLFTPTFKTIVRDVCRQFLPGLYD
VIGHKLQIEEVNEFLTNLIKDTINYRKENKIVRPDFVNTLIELKDHPEKLETI (1)
KLTDSMIASQAFVFFVAGFETSSSTISHALYELAQNQEIQDKLREEIREVYEKHGELTYDV
IKNMKYLDKVLK (1)
ETLRKYPIMAMLTREAQENYTFKGTKVTIEKGIKVWILPYGIQNDPDIFPNPDIFDPERFD
EEAVAARHPMSYLPFGDGPRNCI (1)
GARFAQFQSKIGIITIVRNHKIDVCEQTKIPYESDPFQFLLALKGGINLKISKI*
>CYP6AS14
MYIGLEILCGIVITLIAFYCYLTINNNYWKNRGIPGPKPVPGFGNMKNVIFGKESVSQFLT
RMYNEYKDEPMIGVFSKRTPVLIVKDVDLIKTILIKEFPKFANRGLFPIFS (0)
RDPLTHHLFNLEVERWKPLRTQFTPLFTSSKLKEMFSLILECSNHLESYMDTLIKKGEPID
MREVSARYTTDVVGSCAFGIDMNSLSEKESVFRRLGKLIFATNLRKILSIRIQDMLPWLYN
SFLYVLPRDEKTRIIMKLMTETMEYREENNVFRPDFINMLLNLKKHPEKIDI (1)
ELTDDLLAAQIFIFFAAGFETSSSTISNALYELALNPDIQEKLRKEIKEFEARNNGEWRYE
IMKEMEYLEKVFQ (1)
ETLRKYPSLPFLNRKLINDYTFESNNVTVSKDLKIWIPVYGIHHDPDIYPDPEKFDPERFS
KKEEIMKRHPMHFLPFGHGPRNCI (1)
GARFAVYQTKIGLIKILRNFEVQVCNKTLIPYKVNPYTSLLIPITGLYLNVVKLEN*
>CYP6AS15
MNISLEILCGIIVALIVFYYYLIINNNFWKNRKISGPKPVIGFGNMLSIILGKESTSQFLT
RIYNEYKNEPMIGIFSKNNPALVIKNPDLIKTVLIKDFHKFANRGLFPVNS (0)
REPLSQNLFGLEVERWRPLRIHFSPIFTTNKLKGLCSLILECSEQLEKYMDILIRKGEPLD
IREIAARFTTDVIGSCAFGIEMNSLSENESEFRRLGKGVFNTTFRRIVKTRIRNLMPWLYN
FFLRILPWDEITKKIVKLTTETIEYRNKNNIVRSDFINVLLNLKKHPEKIAEI (1)
ELTNDLLSAQTFVFFGAGFETSSTTISNALYELALNHDIQYKLREEIKEFEKKNDGKWTYE
SIKEMQYLNKIFQ (1)
ETLRKYPVVPFLNRELISDYTFENSKITIPKGLKIWIPVYGIHHDPDIYPNPEKFDPERFS
EDKIKERHSMHYLPFGHGPRNCI (1)
GSRFGTYQTKIGLVKIIRKYKVEICDKTLIPYKFNSFANFLMPSTGLYLMITDVEN*
>CYP6AS16P PSEUDOGENE?
Frameshift at X
MIANLEIFCGIIVILIAFYYYIRLEQFWKFXGIPGPEPLPGFGNVLMIVLGKEAPFQFLT
RVYNEFKNEALIGVFMKTYPALVVKDPDLIKDIMIKDFYKFPNRGFPKSDS
(0?)
XNPLTQHLFLVEEEKWRPLRTQLSPVFSTGKLRGTFTQILDCSNHLVTYMDKLVEIGEPID
VREVTAKFTTDVIGSCVFGIKMNSLSGKESEFRRFGRQIFAMNFLKILRLRIKQFLPMLHY
LLVRILPPDEETKIMLKLTRDTFKFREAHNIVRPDFMNILMELKKHPEKVPSL
(1)
DLTDGLLAAQAFIFFAAGFETSSTTVANTLYELALNPDIQEKLRQEIKEFEANNDGEWKYE
TIQEMKYLDKTFK
(1)
ETLRKYPVLPYLSRRSIEDYTFEGTKVSIPKNTLICIPVYPIHHDSSIYPNPEKFDPERFS
EDEVKKRHSMHYFPFGHGPRNCI
(1)
GLRFAIYQSKIALIKILSNYKIEICDKTLIPYKYDPFSFISLPLTGIFLKITKLQN*
>CYP6AS17 name changed from CYP6AS6v1, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNMDVTRWRPLRIKLSPVFTSGKLKEMFPLILKCAERLEQCLEDAVKRGGPVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKIEKNN*
>CYP6AS18 name changed from CYP6AS6v2, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNLDVTRWRSLRIKLSPVFTSGKLKEIFPLILKCAERLEQCLEDAVKRGGSVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKVEKNN*
>CYP6BC1 MWNIIRELLEQFLLPGLFLGILYCFLTSTFDFWKNRGVPFRKPTVLFGNFAPMLLFRKSLP
EGIKEMYEWFKDERYFGAFRVRSPVLILRDPDLVKNICVKNFTSFSNRGIPVNSQ (0)
DPLSAHLFNLEGKKWKSLRSKLTPAFSSGKLKRMFYLLAECGEEFEKLIDISSETDRPYEI
RELAAKFTIDVIGTCAFGIQINALTDEESEFHRAAKKLSKPSYKATLWRMLRTAMPRLYKF
LGVQVIDPGVTKFFKDVVSQMIKQRGEYGIKRHDFMDLLIELKNKGTLDEFG (1)
KLDENSIAAQAFVFFAAGYETSSNTIAFCLHELALNTEIQEKTRRDIQDAIDSRNGNLTYD
AVQDMKYLDMVIA (1)
ETLRKYPPASMLSRRCEYQYQIPNSKVELPAGIRVIIPIYGLHHDPDYYPSPAIFNPERFT
EENKRTRHPYAYLPFGEGPRNCI (1)
GMRFALLQIKVGIISFLRNHRVETCQKTITPIKFSRRSLVTTSEKGFWLRIK*
>CYP6BD1
MAMQNSLFMPIIFSIAFFVIILILYLKYTRTYWLRRGVPTVPGHWLFGNIKKILDLKKPPA
YVISDIYQKCSENDDILGIYIFFKPFLLIKDPAIIKQILIKDFNYFPDRNFTIQSFYDEIG
NKSLFTLKNPQWKYLR (2)
TKLSPIFSSAKVKKLFHLMVEAANSMNKYLDDEFSNDTKTKTIMIKDVTLKYTTNVISSVA
FGIQVNSFNPKTIQFYEE (1)
AQKGLKTTFSRSMQLCISFFFPKLSPYLNTRMLGSSTNFFRKVFWNSMDNREITKTKREDL
IDSLMELKNAKQDKDF (1)
KFEGDALLSQSAIFFIAGRETSISIICLTLYELAKHPEIQKRTREEINEKLKEHGMTYEGV
QSMKYLHQVVSEILRIYPPTPIIDRVAVADYK (0)
IPGTDIVIEKGTSVFIVLTALHNDPKYHPDPLRFNPDRFSDENKENIKPFTYIPFGEGPRICI(1)
GARIGQLQSIIGLITIIKNYEISFISKCKGDLDVRNIFITPINDFSLNLTKI*
>CYP6BE1
MFLTTWLIPDIIAVASLITVGLYFYYKLYLFKFWHKKGIFYVKPSFPTGNIMPIINGKLSL (1)
AEFFRDIYEHNKHHRLVGIYMLYKPYLIVNDPNLIRDILTKEFTNFHDRGIFYNEEVDPLS
GHLFQLPGKKWRNLRVKLTPTFTSGKIKQFFPILNEAGNILAKYLEEEARKGSTIDVKDIF
AR(2)YSTDIIMSVAFGISCDSFKEPNNEFRYWGKKIFDPKPLWNALILFAPQILNFFSIS
YTEKSVTKFFTNMFKQTVKYRESNNIERKDFLNLLIQLMKNGYVDADDESLSNNVNAA (1)
KNKLTMMEAAAQAYVFFLAGFETSSTTVTFCLYELAKNQDIQNKVREEIQTMIKKNGDLTY
NALNDMNYLHKVIS (1)
ETLRKYPPVVILNRICTNDVKLSTTDFCIPKGTCIAIPVFGLHRDSNIFPNPEKFDPERFS
EENIKTRHPYVYLPFGEGPRICI (1)
GLRFGLIQTKIAIINALLKNKFKFGPNTPSTLEFEKGSLILIGKGGIHLNIEPI*
>CYP9P1 old 335A1
MEVSHLTTFELLLLTLIFIILAKLVSILYTQFTYWKRNKVPYIRSSPLFGTAWRVFFRLVSFPNYCKYIYNYYPDARYVGVMDFATPTVIVRDPKLIKEIAVKNFNNFPDHRSFVTEEMDPVFGKNVFSLKGDRWREMRNTLSPSFTANKMRFMFDLVSKCSHDFVSCLHDRLESSSSEIEGKNLFTRYSNDVIATVAFGISVNSIEHPDNEFYRRGIDVSTFSGTFRFIKFMLFRLNPRLTRMAGFTFLSRATSKFFWRVISETVTARKRRGIVRPDMIHLLMQATDSKKKSIHQTMTIDDIVAQAFIFFLAGFDTTSTLMCYVVHELALHQDVQRRLREEVDRVLDDGTEISYEDTLGMEYLEMVISETLRMHPPTLLIDRQCAKEFHLPPAGPGYESVTIHPGENIWFPVLAIHRDPAHFPDPDKFDPERFNRENRNGIDPYTYIPFGVGPRKCIGNRFALMETKLLIIRLLRKFVIKPCERTMDPIVYKKGNFTLMPKDGFWVTFEKRNDH*
>CYP9P2 old 335A2
MESPTLLFSFELLAIGLTAIVLAKFVSLLHHQYNYWRKRRVPHVGAVPVLGSSWRIFTRRMSLPNFCSLVYKHRPGSRYLGMMDCFTPVVVVRDPNLIKEIAVKNFDHFPDHHSFINEKIDPIFGKNVFSLKGDRWREMRNTLSPSFTASKMRFMFDLVSNCSEEFVRYLYDHPEFSSSIEAKDAFTRYTNDVIATVAFGISVNSMENRDNEFYTKGADATNFGGIFRLFKFMLFRVNPRLTRMAGLSFLSRGTATFFHRVVRETVRARDERRIVRPDMIHLLMQARDKEDRRPVATVDNRMTIDDITAQAFIFFLAGFDTSSTLMCYVAHELALNPPVQERLREEVDRFMDGGNGAITYEALLKMEYMDMVTSETLRKYPPIVFIDRLCVEKFELPPAEQGYDHLIVHPDNIVWFPVYGLHHDPKYFPEPEKFDPERFNDANKRNIVPYTYMPFGLGPRKCIGNRFALMETKILIAYMLRKFRIKRTEKTRASIEFSKTNFSLTPDHGFWIGLEKRDP*
>CYP9Q1 old 335B1
MDYLQLGLTLLAILVAVYYLSTRNHKLLKRHGIVHIPPTPLFGNLGPLVRRKCHMEDVIQRVYDLDPDARYVGMYEFTTPLIIIRDPELIKTIGVKEITNFTNHRPFVDVGVDPMLGEVLFAMQGDRWREHRTMLTTLFTSSKIKSMFVLMSDCAKRFADYLSKVEREIELKSVLTRYTNDVIARCVYGVSVDSVNEPENIFYRYGQVASQLSTFKQNLMIFVHRNSPRLARLFNLKILPVHIEKFFHRLVMDTIETRRREGVHGLDMLQQLMDMQSRRKESEEGKRGMTVTDIANHAFSFFFGSVDTMATQISLISHMLAVNPDVQQRLQEEIDEVLSASEDKQVGYDVIQEMKYLDAVMSEAMRYHPILLFVDRVCGETFELPPALPGARPFKLERGMNIWFPVKAIHHDPKYFENPDRFDPDRFLRDGKGIASSGAYMPFGMGPRKCIGSRFALTEMKILLFNILAKCSFKVGSKTMVPLKFKEGVFNPVAKNGFWLKIERRENSCC*
>CYP9Q2 old name 335B2
MEFLSLALVLAAISIIAYYYCFVRKNFNLFQEHGILHVPPSPLVGNFGPLIRGKENVHDTIQRIYNIHPDAKYVGIFEFLTPVIMIRDLDLIKSITMKNFDQFPDHRPMFCKSVDPMLGEMLFIMDGERWKEHRNMLSPTFTSSKIKTMFVHMSECAKRFAHHLSKLPEKDRETEMKALLTRYTNDVIAACIYGVNVDSIKEPRNVFYMYGRVGATLIGLKKNLKIMVHRNMPWLANLLRLNILERHIAKFFTDLVVETVEERERNGTTNSDLIQLMMDTRNKKESGKKNLTVQNMANHAFSFFFGGFDTVSSQTCVLLHMLVENPEVQQRLQQEIDETLESNNGQLSYDVIQEMRYLDAVINEILRLHPIAVFIDRMCVKSFELPPALPGDVPFTVKPGMNVWIPVKAIHHDPRYYDEPEKFKPERFLDNGKNIIGSGAYFPFGIGPRICIGNRFALIEMKVLVCHILAVCDIKAGARTGIPLEFEKGVFNATAKTGFWLKIEPRKYSYHSGQINGLVNNHVINGACKTGI*
>CYP9Q3 old 335B3
MDYLTISLSLITVFVAVYYLATRNNDFFKKHGIPHVPPVPFLGNMGSLVRQKSNLHDVIDRTYNLDPGAKYVGIYEFTTPIIILRDLDLIKTITMKYLDHFPDHRSFAYEGADPVFGSMLFAMKGERWKEHRNMLTPTLTSSKIKGMFKLMTECAVRFADFLSVLPENERETEMKALLSRYANDVIASCVYGVSVDSINDPKNIFYVYGRRGTNVVGLKKSMFVLIHRNMPWLAKLFGLRFLEKHVQKFFYDLVYETIESREKLGTNRSDVLQLLMDIRDKANSSGKMTTMTVENVAIHAFTFFFGGFDSITSVTTLLTQMLAEHPDVQARLQQEIDETLRSNDGVLTYDAVHGMKYMDAVINETMRFCPVLPFLDRMCVESFQLPAPVPGGQPFTLRPGMNVWIPLAAIGRDPEYFEDPDKFDPDRFLNPEAGIKNSGAHFPFGLGQRKCIGERFAMMEMKVLLCYVLAACNVRIGSKTTVPMKLEKGLINANVKGGFWLKIEPRKVTYYNSSRSN*
>CYP9R1 old 335C1
MLDSWSITAAIVAVLAIAYYQLIWKYKHFERIGIPCYHSIPLLGSFWEAVIQRNNFAEISRKIYNSYPDTKYMGMYDTTTPVLLIRDTELIKAISVKHFEQFPDHRSFQNEATDPLFAKNLFALRGDRWREIRNLLSPAFTSSKMKSMFILMRDCAKEYGDYFASLTGDESTIELKDAFTRYTNDVIATCAFGVEVNSMKDRKNKFYVYGREGTTFGSWASIKFFVTRVLPVSVCTLLRIRLIRKEISDFFIDLVSTTIKTREEKGIVRPDMIQLMMESKGKLGAGKEMSMIDICAQAFVFFFGGFESTSTLMCFAAYEIAVNEDIQRRLQNEIDQVLEERDGEVTYAAVNEMKFLDAIIYEALRMYPVVVATDRVCMKPFELPPNRPGEKPYLLKEGDNVWFPIYAIQRDPQYYPEPDKFDPDRFLNDTKQMINSGLFLTFGIGPRMCIGNRFAMLETKVLLFHLFARCNLVPCSKTTIPMKLNRKGFSMTAENGFWFKIEPRSAKKEEKIAVPGTTMLIDKIPDRYPDN*
>CYP9S1 old 335D1
MAIFALLLIVLGILGSYHLLKSQNPFKEHGLPYKSYLPILGSTWESILRRKSFAVVIQEIYNLAPSARYVGFYNRTTPIVMIRDPELIKTIAVKNFDAFRNHRTVNDTQTDDVLLSGNLLLLRDNRWREVRSLNTPAFSTSKIRSMYRSMSEIAINVARYLSTLAPGQNIVEMKDIFTRYANDVFATCAFGISVDSLSDRENKFYELGREALDIHSTPILKLILIFAFPKLARRLGVSLVSKEATNFFTRVVSENIKMREEKGITRPDFIQAMIDKRNGRGRDDELTVEDITAQAFVFFFGGFETTSGLLSFAVHELAANPEIQGKVHAEIDRVLVSNNEITFERVNGLMYLDAVINETLRMYPIIPITDRECSKRFELPPVLPDAKPYVLKEGSHVWFPIYAIQRDPRYFEKPDCFDPDRFLDDNKKRSDAFNGDAYMPFGAGPRNCIGNRFSMVETKVALFHILAKCRLDVCPKTTIPMELRKRGVFLTAKNGFWLRIVPRHPVT*
>CYP336A1
MASAFLTLVTGALLLLCFYLYLKYTYWKRNGIPYSKGYYPIIGHFLPLIMKKQSYSEIIEEIYRDSNHSMVGMYKGMKPVLILRDINLIKTVLQSNFSKFHENAVKIDPKLDPLLAKNPFFCYGELWQTGRKRLTYAFSNARLKILFAAVYEVCTKFRNFLDRRLESSKKYEVELKSLFLKFTSEVVANAGLGIEGFCFEDDKVQSMFTNLDNNDFLDTFLIGIIVHFPFLTKLLRIQFLPTKHDKFFRTVVKKNLELRKSDPIPRNDFIQLMIEMEQTGEKIDEEIVAAHAVSFYLDGVETSSVTLNFIGCQLAIHQDVQEKLRKEVRSTLEKHGGVLTFEALKDMTYMNQVISESQRYFSALGFLGKICTDEFELQGSDGLNYRAKPGTELLIPICGLHKDPKYWDNPEIFDPERFSDENKQRIEKMAFIPFGEGPRICVGMRMAMLQMKSCLATLMKDYKLEVSPKMQLPLKLSPTYFLSAPLGGGWVLISKA*
CYPmito clan CYP12, CYP49, CYP301, CYP302, CYP314, CYP315, CYP334
>CYP301B1 name changed from CYP49A1 because it has higher seq
identity to CYP301, but Drosophila, Aedes, Anopheles, and Bombyx all have CYP49 related sequences, so it seems logical that Apis will also. This is the best candidate for a CYP49A1 ortholog.
50% to 301A1 Anoph. 46% to 49A1 Anoph. 50% to 301A1 Anoph. (but better expect value for 49A1 –150 vs. –142)
49% to 301A1 Dros. pseudo. 45% to 49A1 Dros. pseudo.
MQILNCKFTKLLKNTVKQSNNIIKTLETLTTEVEEQDWSRCRPYSEIPGPKPIPFLGNTWRFIPFI (1)
GDFKIQAVDQVSKKLYKEFGDIVKVEGLLGRPDMVFIYDANEIERIFRQEERMPYRPSMPS
LNYYKHVLRKEFFKENAGVIAV (2)
HGESWYNFRSKVQQVMLQPRTARMYITSMEEASLAFLER (2)
IKKIRNKNDEVPDDFLNEIHKWSLE (1)
SIARVALDVRLGCLDDDANIETQQLIDAVTTFFKNVGILELKIPFWKLFNTPTWLKYVNALDTILS (2)
ITSRYTTVALSRTKEAEKSDKEPSLLERVLALENDTKLATILSLDLFLVGIDT (0)
TSSTVASTLYQLALHPDEQDRAYNEVCNILPSKDMQLDGKHLDKLKYLKACIKETLR (2)
MYPVVIGNGRCMTKDTIIKGYRVPKG (0)
VQVVFQHYVISNLDKYFPHSDKFLPERWLQSDGVRHSFASLPFGYGRRMCLGRRFAELEMLVVISK (0)
ILQRYKIEYHHEKLEYYINPMYTPKGSLNLKFIDR*
>CYP301A1 68% to 301A1 Drosophila 45% to 49A1 Drosophila
67% to 301A1 Anopheles, 46% to 49A1 Anopheles
MMTGKTRYLFFKIHFLLLYVLI (2)
CMVDHDTTTIQQGKPYKDIPGPRPIPILGNTWRLFPMIGQYEISDIAKLSQIFYDEYGKIV
RLTGLIGRPDLLFVYDVDEIEKIYRQEGPTPFRPSMPCLVHYKSVVRKDFFGSLPGVVGV (2)
HGEPWREFRTRVQKPILQPQTVRKYITPIEMVTSDFIQR (2)
IQEIKGEDGEVPGDFDNEIHKWALE (1)
CIGRVALDVRLGCLSSNLTSDSEPQKIIDAAKFALRNVAILELKAPYWRYVPTLLWSRYVRNMNYFIE (2)
VCMKYIDATMERLKTKKAVDEYDLSLMERILAKETDPKIAYILALDLILVGIDT (0)
ISMAVCSILYQLATRPEEQEKIYQELVEILPDPSVPLNMSHLDKAIYMKAFIREVFR (2)
VYSTVIGNGRTLQNDTIICGYKVPKG (0)
VQVVFPTVVTGNMEKYVTDAKIFKPMRWLKESTKTLHPFASLPYGHGARMCLGRRFADLEIQVLLAK (0)
LIRSYKLEYHHKPLKYKVTFMYAPDGELKFKVLPR*
>CYP302A1 hybrid seq from parts not joined in genome assembly
MCTLLKKCNQSIRKKLFIKFYSNEFTKSKIKINHSQPKAFYDIPGPKSLPIIGTLYKYLPFIG (1)
EYSFTNLYESGKKKLKCFGPLVREEIIPNVNVIWIYRPEDIAEIFKAESGLHPERRSHLALLKYRKDRPNIYNTGGLLPT (2)
NGSEWWRLRKEFQKVSSKPQDVINYLKETDCVIQEFVELCNNEKFADFLPLLSRLFLEL (1)
TCLVVFDIRLNSFSKEERCENSISSKLIKAAFATNSAILKLDNGLQLWRLFETPLYRKLRKAQTYMEM (2)
IALELVSRKKNNMKIRYNKSFLDAYLENPVLDIKDIVGMACDMLLAGIDT (0)
TSYSTAYILYHLAKNQNIQEKLRIEATQLLKNHNEPISINILRNASYTKAVIKESLRLNPI
SIGIGRILQTDVVLSGYRVPKG (0)
SVVVTQNQIICRLPEYFEEPNLFIPERWLREYSENNNKINYKKTVHPYVLLPFGHGPRSCI
ARRFAEQNMQILLLR (0)
ICRRLKISWHGDDLGMISLLINKPNALLKFNFHDILNNNSV*
>CYP314A1
MLLSSAWFEVIAAVLLTILIFVTSHRPAWWFWTATSHEAS (1)
APAEGKFKTVSKVPGPFSLPIFGTRWIFSCIGYYKLNKIHDAYK (1)
DLNQRYGALCKEEALWNFPMISVFSRQDIETIIRRNSRYPLRPPQEVISHYRRTRRDRYTNLGLVNE (2)
QGQTWHDLRVALTSELTAASTVLGFFPALNIVADSFIELIRRQRVGYKVTGFEELAYKMGLE (1)
STCTLILGRHLGFLKPDSSSELATRLAEAVRIHFTASRDAFYGLPLWKLLPTCAYKQLIESEDAIYN (2)
IISEIIETTIQEKRDDAKDESVEAIFQSILRQKNLDIRDKKAAIVDFIAAGIHT (0)
LGNTLVFLFDLIGRNPAVQNKLYEETYALAPAGCDLTIDNLRKAKYLRACITESLR (2)
LIPTTTCIARILDEPIELSGYRLTAG (0)
TVVLLHTWIAGLNEENFKDAKKYLPERWTTPTTPHSPLLVAPFGAGRRICPGKRFVDLALQLILAK (0)
IIREFEIIVEEELDLQFEFILAPKGPVSLGFRDRS*
>CYP315A1
MNLAQNILKSGKSVSLSSNVIALKYNVPGCGYAGASQTSRIDDLSDISKSTDGGNRSKIEI
TEKLRDRNYGTVAVATSESILQEMPEPRGIPVFGTLFSFILSGGPKKQHEYVDKRHKELGP
VYKERIGPTTAVFVNSIHEFRKIFRLEGSTPKHFLPEAWTLYNEIRKCRRGLLFM (2)
NGEEWVYFRKILNKVMLLPDPTNLMIAPCQEVAIELKRKWQKQIKTNNIISNLQVQLYQWSIE (1)
AMMATLMGSYWYSYKHQLSRDFEILAETLHEIFEYSAKLSIIPVKLAMNLRLPVWKKFVAS
ADTAFEIVRMLVPEMAKLGGNGLLKKMMDEGIRAEDAICIVTDFILAAGDT (0)
TATTLQWILLLLCNHPEKQEELFKHLKDLSQEDILRLPLLKGIIKESLRLYPIAPFISRYL
PEDSVIGNYFVPKG (0)
ELLVLSLYSSGRDAANFPQPNEFRPERWIRTQKGIYQGVVHPHASLPFALGARSCIGRKLA
EIQISFALAE (0)
LIKSFKIECINKNQVKLILHLISVPSQSIKLKLMERN*
>CYP334A1
MTESQTASVDESLRTDTIPLLDHTATTEVSPTTFEVSTMKVDTQIFDKAPLPFDEIPGPAI
LKIWEKYWKYVPLL (1)
GRLTWNRNITPLKYLFNEYGCIVRINGPLSGDIVMIHR (2)
PEHIAEVFKQEGDTPVRSGIDILQHYRLNYRKYRLAGPFSM (2)
QGTEWLEIRDKVEDTFNQISSTFFTKIDTCCNELITRICKIRNRQNE (0)
VPVSFYEDLIRWAMECFCDLTFNKRLGFLEPIGYNSSSEASKLINALTTAHKYMSRCETGF
QVWRFFLTPFARKLFEACDVLDN (2)
VIGKYVRQAQCKLRIRKSHSEESSMTERSPVLEKLLLNEGIHPDDICTMLMDMIILGIQA (0)
TVNSEAFLLYHLAKNPRTQRKVYDEIISVLSNDNSSFTEKSLKNMPYLKACIQETLR (2)
LHPAIPYITRLLPKTISLHGYTIPKG (0)
TFVIMANQITSQREENFEDPFKFWPERWLSNSSKEDVHFSYLPFGHGIRSCLGKNMAEAKMMLLTAK (0)
LVRQFRIEYDYADIKSRFMMVNVPNKPLRFRFVNRN*
Fragments of P450s
>Am2_6006 INCOMPLETE 5 aa diffs to 6AS12
YGRIVHGTESDSLLKDPELIKDVLIRDFSKFADRGFNVHEK (0)
VEPLSQHLFNLEPKRWRPLRSKLSPMFTSKKLKEMFGLILECGRHFEKYVDGLAARRQPVD
FCEVAAKYTTDVIGSCAFGINMNAMSSEGSEFREAGRKIFEPTWNSIIRLKFKITMPTLYD
LLGPLVPEREVTPFFIKVVTDAMKYKKESNVFRPDFIDTLMKLRDDPESLSDI (1)
ELTDAFLTAQAYVFFAAGFETGASTISNTLYELAQNQGMQDRLREEIREHCDKYGGELMYE
NIKEMEYLDKVFK (1)
XTLRKYPPGTLIPRRSVSEYTFKNTNVTIPKGTMIWIPAFPIHRDPDIYPNPDDFNPENFT
EDAINNRHPMNYLAFSNGPRNCIG (1)
>CYP6AS2-1like FRAGMENT GB19197-PA 209aa 3 exons gnl|Amel_2.0|GroupUn.5353 minus (2931-2710,2531-2286,2114-1950) 51% to D. melanogaster CYP6a17(AC020447) pseudogene fragment, similar to C-term of CYP6AS2 100%
(1)LTDILLTAQAVVFFVAGFETSSSTMAFSLYELAQNQEIQDKLREEIRKVHEKNKGVLT
YTDIKEMKYLDKVFK (1)
ETLRKYPILSTLSRKVMENYTFKGTKITIPKGTKIWVHGIQHDPNIYPEPEVFDPERFEDD
AFASRHPMSYLPFGDGPRNCI (1)
GLVLPHYQSKVGLITILRNHKXVNVCEKTTIPFKADERSFLLVPKGGIHLKIIKI*
>Am2_101397060 FRAGMENT GB19113-PA first 29 aa same as 6AS14
XTLRKYPSLPFLNRKLINDYTFESNNVTVSQRFKRFWIPVYRNLTPISDIYPDPEKSHL*K
ISLGGNYGEGAPKAFLPFGQGPQNMSCVWPIK (0)
>Am2_98681617 FRAGMENT GB12136-PA nearly identical to 6AS12
VDVAFYYYFTSALNFWKIRGIPGPHXPKFLFGNIRDIILSRISTPTFIKNVYDTYTNEPMV
GLYMARNPILLLKDPELIKDVLIRDFSKFADRGFNVHEK (0)
>Am2_98611857 FRAGMENT GB14612-PA
PRDGSSQEKFDPERFSEENIKLGHPEVYLPFGEGPRIL (9)
IGLRFGLIQTKIAIINALLKNKFKFRPNTPSTSEFEKGSLILIGTGGIHLNIEPL*
>CYP6AS2-2like FRAGMENT GB11798-PA 1st exon of CYP6AS2
MDYFQILCAISIVILTIYYYYSLKYAFWKDRGISGPKPIIFFGNLGNSIIKKKSLSETVKK
WYDDYKHESVFGIFEGTIPVLVINDLDMIKDILIRDFSLFVDRGFHIFPK(0)
>Am2_79040249 FRAGMENT GB11754-PA
(0)KVPLTNHLFALEVKRWRPLRNHLSPVFTSGKLKGTFAQILNXAPMILXDSYRHFIEDG
RLYKHAREVAAKFTTDVIGSCVFGIKMNSLAEREXEFRRIGRNIFATNFTNILKIRLLTST
PLLHSLLCRILPDEEMRXMFFRITKETMEYREKNNPPQAGFYEYTSRLETEV
>Am2_48488186 FRAGMENT GB12885-PA
DTLSKMEDSINMREVAAKFTTDVIGXSCVFGIKMNSLSEIENEFRRIGRNIFATNFTNILK
IRLLQSTPFLHSLLCKILPDEEMEMFMRITKETMEYREKNNLVRPDFMNILLELKKHPERIADIG (1)
>CYP6AS11-like FRAGMENT GB11027-PA
MYIGFEIIYGIVIVFIAFYYYLTINNNFWKHRGISGPKPVLGFGNMKKIILGEESMSQYLT
KLYHKYKNESMIGIFRLRTPALIIKDPDLIKIVLIKDFSKFMNRGLLPIIS(0)
>CYP4AZ1-like FRAGMENT GB10905-PA 55% to CYP4AB1(AAP97090.1)
(0)DRPPAEIKAAIEENGGKLNITVLQFFSDLERCIKESLRLFPTVAGGSKLETSRVKF (1)
>Am2_Un.5369 FRAGMENT GB18672-PA 96% to CYP6AS9
EIENEFRRIGRNIFATPFYKYIEDRLLQSTPLLHSLLCKILPDEEMEMFMRITKETMEYRE
KNNLVRPDFMNILLELKKHPERIADI (1)
EITDDLLAAQAYIFFAAGFETSSTTISNALYELALNHDMQDKLREEIKEFEAKNDGEWRYE
TIKEMQYLGKIFQE (1)
ETLRKYPALSFLSRESIIDDYTFRDTKLTISKGTLVWIPVFPIHHDPNIYPEPEKFDPERF
TEDKIKERNLMHYFPFGHGPRNCI (1)
GARFAIYQTKIGLIKILRNYKVDVCSKTLIPYKYDPFSFILVPLGGLYLKITRIQD*
>Am2_57889394 FRAGMENT GB17793-PA
ETVEDTERNGTTNSDLIQLMMDTRNKKESGKKNLTVQNMANHAFSFFFGGFDTVSSQTCVL
LHMLVENPEVQQRLQQEIDETLESMMNYSKYQFS (1)
>Am2_14.6
PSEUDOGENE 38% to CYP9L1(AAAB01008986.1)
DSFRYSAHFANSSS*KNPVGPVLAQSSSKREILLDFTLNPSINQGDSFDRFIDRSSTRNIFSF*GAKGRKR*GILSPSFTMNEIDVRNCSQVCGSFALIYPRWTQRKILSSATT*SFIYQILLESV*IRWKTTSQFPLMRFRVHD**DY*E*FLKSTIFDFVPRVVSNGIEWRTRHR*TGYTAFIARNKEKSSIDKMTIDDIVSRAIRFSTWMALTLALSNFMRFVLYDPAFGWRGKEIDG*NILRILRRVYTGMMMSETLGKYSGLIFVDRVCTRKFALSGAGYDGATLYPGDIVFSPYVGSRS*IFFRSRNEKNEGNIVPYWNLLLEIKIFMIPSRRFSIRLNEKTPEAYRLSEK*SCIHS*RRNLD*IGRKERL*ILWLVKNFVHYFAKRFM