P450
families and subfamilies (last modified Jan. 8,2005)
red
entries are new since Sept. 4, 2002
green
entries new since Jan. 17, 2004
blue
entries are new since May 7, 2004
magenta
and rose entries are from Jan. 8, 2005
D. Nelson
CYP1 to
CYP2 292 lines of entries. 12 are alleles, v1, v2 etc.
so there
are 280 entries of unique sequences in CYP families 1 and 2.
For
CYP3-CYP9 483 lines, 52 are alleles v1, v2 etc. so 431 are unique genes
For
CYP10-CYP51 236 in animals, 2 alleles so 234 unique sequences
For
CYP301-323 32 sequences (977 total for animals)
190 total
for lower eukaryotes
Plants
have 636 lines 29 alleles so 607 plant sequences named
(soon
there will be about 450 more rice genes named)
Bacteria
184 sequences
Total 1958
sequences are named.
animals 1587 lines
- 74 alleles = 1513 different named sequences
lower
eukaryotes
614 unique named sequences
Fungi =
483 unique named sequences
Other lower euks =
131 unique named sequences
plants 1141
lines - 34 alleles = 1107
different named sequences
bacteria 484 lines
- 15 alleles = 469 unique named
sequences
total 3826
lines - 123 alleles = 3703
different named sequences
2005
stats Jan. 8, 2005
animals 1160 lines - 79
alleles = 1581 unique named sequences
plants 1776 lines - 36
alleles = 1740 unique named sequences
fungi 511
lines - 3 alleles = 508
unique named sequences
Lower
euks 204 lines -
1 allele = 203 unique named sequences
bacteria 487 lines - 15 variants = 472 unique named sequences
Total
4504 unique named sequences
CYP1A1 human
CYP1A1 Macaca mulatta
(rhesus monkey)
Cyp1a1 mouse
CYP1A1 Cavia Cobaya
(guinea pig)
CYP1A1 rat
CYP1A1 hamster
CYP1A1 rabbit
CYP1A1 Macaca irus (crab eating macaque
monkey)
CYP1A1 Macaca fasicularis (crab eating
macaque monkey)
CYP1A1 Sus scrofa
(pig)
CYP1A1 Macropus
eugenii (tamar wallaby)
CYP1A1 Balaenoptera acutorostrata (Minke whale)
CYP1A1 Phocoenoides
dalli (Dall's porpoise)
CYP1A1 Eumetopias
jubatus (Steller sea lion)
CYP1A1 Phoca largha
(Spotted seal)
CYP1A1 Phoca fasciata
(Ribbon seal)
CYP1A1 Halichoerus
grypus (grey seal, gray seal)
CYP1A1 Phoca
groenlandica (harp seal)
CYP1A1 Ovis aries
(sheep)
CYP1A2 human
CYP1A2 Macaca
fascicularis (cynomolgus monkey)
CYP1A2 Macaca fuscata
(Japanese macaque)
CYP1A2 rabbit
CYP1A2 dog
CYP1A2 rat
CYP1A2 Mesocricetus auratus (hamster)
CYP1A2 Cavia cobaya
(guinea pig)
CYP1A2 Cavia porcellus
(guinea pig)
CYP1A2 chicken
CYP1A2 Eumetopias
jubatus (Steller sea lion)
CYP1A2 Phoca fasciata
(Ribbon seal)
CYP1A1/CYP1A2
chimera Phoca fasciata (Ribbon
seal)
CYP1A2 Halichoerus
grypus (grey seal, gray seal)
CYP1A2 Phoca
groenlandica (harp seal)
Cyp1a2 mouse
CYP1A1 Oncorhynchus
mykiss (trout)
CYP1A3 Oncorhynchus
mykiss (trout)
CYP1A Pleuronectes
platessa (plaice, a fish)
CYP1A Opsanus
tau ( oyster toadfish)
CYP1A
Stenotomus chrysops (scup, a fish)
CYP1A Chaetodon
capistratus (four-eye butterfly fish)
CYP1A
Dicentrarchus labrax (european sea bass)
CYP1A1v2 Dicentrarchus labrax
(european sea bass)
CYP1A
Microgadus tomcod (Atlantic tomcod)
CYP1A Pagrus
major (wild red sea bream)
CYP1A Sparus
aurata (gilthead sea bream)
CYP1A Liza
aurata
CYP1A Liza
saliens (leaping mullet)
CYP1A Limanda limanda
CYP1A
Platichthys flesus (European flounder)
*CYP1A Danio
rerio (zebrafish)
CYP1A1 Salmo salar
(salmon)
CYP1A Anguilla
anguilla (European eel)
CYP1A Anguilla
japonica (Japanese eel)
CYP1A4 Gallus gallus (chicken)
53% to 1A2 chicken
CYP1A5 Gallus gallus
(chicken) 66% to 1A2 chicken
CYP1A5 Meleagris
gallopavo (turkey)
CYP1A6 Xenopus laevis
(African clawed frog)
CYP1A7 Xenopus laevis
(African clawed frog)
CYP1A8P human
CYP1A9 Anguilla
anguilla (European eel)
CYP1A9 Anguilla
japonica (Japanese eel)
CYP1B1 human
CYP1B1 rat
Cyp1b1 mouse
CYP1B1 Platichthys
flesus (European flounder)
CYP1B1 Danio rerio
(zebrafish)
CYP1B1P Danio rerio
(zebrafish)
CYP1B1 Cyprinus carpio
(common carp)
CYP1B1 Fugu rubripes
(Takifugu rubripes) Japanese pufferfish
CYP1B1 Tetraodon
nigroviridis (freshwater pufferfish)
CYP1B1 Anguilla
japonica (Japanese eel)
CYP1B1 Oreochromis
niloticus (Nile tilapia)
CYP1B1 Stenella
coeruleoalba (striped dolphin)
CYP1B1 Pleuronectes
platessa (plaice)
CYP1B2 Cyprinus carpio
(common carp)
CYP1C1 Stenotomus
chrysops (scup, a fish)
CYP1C1 Fugu rubripes
CYP1C1 Danio rerio
(zebrafish)
CYP1C1 Tetraodon nigroviridis (freshwater pufferfish)
CYP1C1 Anguilla
japonica (Japanese eel)
CYP1C1 Cyprinus carpio
(common carp)
CYP1C2 Stenotomus
chrysops (scup, a fish)
CYP1C2 Fugu rubripes
CYP1C2 Danio rerio
(zebrafish)
CYP1C2 Tetraodon nigroviridis (freshwater pufferfish)
CYP1C2 Fundulus
heteroclitus (killifish)
CYP1C2 Cyprinus carpio
(common carp)
CYP2A1 rat
CYP2A2 rat
*CYP2A3 rat
Cyp2a4 mouse
Cyp2a4-de7b
mouse = w in fig. 2 panel B, old Cyp2g-ps
Cyp2a5 mouse
CYP2A6 human
CYP2A6v2 human
CYP2A7 human
CYP2A8 Mesocricetus
auratus (hamster)
CYP2A9 Mesocricetus
auratus (hamster)
CYP2A10 rabbit
CYP2A11 rabbit
Cyp2a12 mouse
Cyp2a12-de1b2b
mouse = s in fig. 2 panel B, old Cyp2a20-ps
CYP2A13 human
CYP2A14 Cricetulus griseus
(Chinese hamster)
CYP2A15 Cricetulus griseus
(Chinese hamster)
CYP2A16 Mesocricetus auratus
(Syrian hamster)
CYP2A17 Cricetulus griseus
(Chinese hamster)
CYP2A18PC human pseudogene
CYP2A18PN human pseudogene (formerly
CYP2A7PT)
CYP2A19 Sus scrofa (pig)
Cyp2a21-ps mouse = t in fig. 2 panel B
Cyp2a22 mouse
Cyp2a22-de1b2b
mouse = u in fig. 2 panel B, old Cyp2a23-ps
CYP2A23 Macaca mulatta (rhesus
monkey)
CYP2A24 Macaca mulatta
(rhesus monkey)
CYP2B1 rat
CYP2B2 rat
CYP2B3 rat
CYP2B4 rabbit
*CYP2B5 rabbit
CYP2B6 human
CYP2B7P1 human
*CYP2B8 rat
Cyp2b9 mouse
Cyp2b9-de9b
mouse = x in fig. 2 panel B, old Cyp2b25-ps
Cyp2b10 mouse
*CYP2B11 dog
CYP2B12 rat
Cyp2b13 mouse
Cyp2b13-de1b2b7b
mouse = y in fig. 2 panel B
CYP2B14P rat
CYP2B15 rat
CYP2B16P rat
CYP2B17 macaque monkey
CYP2B18 guinea pig
Cyp2b19 mouse
Cyp2b19-de7b8b9b
mouse = v in fig. 2 panel B, old Cyp2b24-ps
CYP2B21 rat
CYP2B22 Sus scrofa (pig)
Cyp2b23 mouse
Cyp2b26-ps mouse see fig. 2 panel B
Cyp2b27-ps mouse see fig. 2 panel B
Cyp2b28-ps mouse see fig. 2 panel B
CYP2B29 hamster
CYP2B30 Macaca mulatta
(rhesus monkey)
CYP2C1 rabbit
CYP2C2 rabbit
CYP2C3 rabbit
CYP2C4 rabbit
CYP2C5 rabbit
CYP2C6 rat
CYP2C7 rat
CYP2C8 human
CYP2C8-de6b
human 10q23.33 = x in fig. 2 panel
C old CYP2C60P
CYP2C9 human
CYP2C9-de1b
human 10q23.33 = z in fig. 2 panel
C possible alt ex1 for 2C9
CYP2C9-de2c3c
human 10q23.33 = y in fig. 2 panel C old
CYP2C59P
CYP2C11 rat
CYP2C12 rat
CYP2C13 rat
*CYP2C14 rabbit
*CYP2C15 rabbit
*CYP2C16 rabbit
CYP2C18 human
CYP2C19 human
CYP2C20 Macaca fasicularis
(monkey)
*CYP2C21 dog
*CYP2C22 rat
CYP2C23 rat
CYP2C24 rat
CYP2C25 Mesocricetus auratus
(Syrian hamster)
CYP2C26 Mesocricetus auratus
(Syrian hamster)
CYP2C27 Mesocricetus auratus
(Syrian hamster)
CYP2C28 Mesocricetus auratus
(Syrian hamster)
Cyp2c29 mouse
Cyp2c29v2 mouse
CYP2C30 rabbit
CYP2C31 Capra hircus (dwarf
goat)
CYP2C32 pig
CYP2C33v1 pig
CYP2C33v2 pig
CYP2C33v3 pig
CYP2C33v4 Sus scrofa (pig)
CYP2C34v1 pig
CYP2C34v2 pig
CYP2C34v3 pig
CYP2C34v4 pig
CYP2C35 pig
CYP2C36 pig
Cyp2c37 mouse
Cyp2c38 mouse
Cyp2c39 mouse
Cyp2c39-ie6b
mouse = y in fig. 2 panel D, duplicate exon 6
Cyp2c40 mouse
CYP2C41 dog
CYP2C42 pig
CYP2C42P1 pig
CYP2C43 macaque
Cyp2c44 mouse
CYP2C45 gallus gallus
(chicken)
CYP2C46 rat
CYP2C47 Phascolarctos
cinereus (koala)
CYP2C48 Phascolarctos
cinereus (koala)
CYP2C49 Sus scrofa (pig)
Cyp2c50 mouse
Cyp2c52-ps mouse
Cyp2c53-ps mouse
Cyp2c54 mouse
Cyp2c55 mouse
CYP2C58P human 10q23.33 inside 2C cluster
CYP2C62P human 10q24.31 outside 2C cluster on chr 10
Cyp2c65 mouse
Cyp2c65-de9b
mouse = z in fig. 2 panel D
Cyp2c66 mouse
Cyp2c67 mouse
Cyp2c68 mouse
Cyp2c69 mouse
Cyp2c70 mouse
Cyp2c71-ps mouse see fig. 2 panel D
Cyp2c71-de1b
mouse = x in fig. 2 panel D
Cyp2c72-ps mouse see fig. 2 panel D
Cyp2c73-ps mouse chr 14
CYP2C74 Macaca mulatta
(rhesus monkey)
CYP2C75 Macaca mulatta
(rhesus monkey)
CYP2C-se1[7]
human 2q24.3 =
old CYP2C56P away from 2C cluster
CYP2C-se2[1:2]
human 10q21.3 = old CYP2C61P outside 2C
cluster on chr 10
CYP2C-se3[1]
human 21q21.2 =
old CYP2C63P away from 2C cluster
CYP2C-se4[1]
human Xq28 =
old CYP2C64P away from 2C cluster
Cyp2c-se5[9]
mouse chr 16
CYP2D1 rat
*CYP2D2 rat
*CYP2D3 rat
*CYP2D4 rat
*CYP2D5 rat
CYP2D6 human
CYP2D7P human
CYP2D8P human
Cyp2d9 mouse
Cyp2d9-de1b2b
mouse = x in Fig. 5 panel A
Cyp2d9-de1c5c6c7c
mouse = y in Fig. 5 panel A
Cyp2d9-de1d6d7d
mouse = z in Fig. 5 panel A
Cyp2d10 mouse
Cyp2d11 mouse
Cyp2d12 mouse
Cyp2d12-de1b5b6b7b
mouse = v in fig. 5 panel A
Cyp2d12-de5c6c7c
mouse = w in fig. 5 panel A
Cyp2d13 mouse
CYP2D14 bovine
CYP2D15 dog
CYP2D16 guinea pig
CYP2D17 Macaca fasicularis (
cynomolgus monkey)
CYP2D18 rat
CYP2D19 Callithrix jacchus
(white-tufted-ear marmoset)
CYP2D20 hamster
CYP2D21 miniature pig
Cyp2d22 mouse
CYP2D23 rabbit
CYP2D24 rabbit
CYP2D25 Sus scrofa (pig)
Cyp2d26 mouse
Cyp2d26-de1b7b8b
mouse = s in fig. 5 panel A
CYP2D27 syrian hamster
CYP2D28 syrian hamster
CYP2D29 Macaca fuscata
(Japanese monkey)
CYP2D30 Callithrix jacchus
(white-tufted-ear marmoset)
CYP2D31P human 2D6 pseudogene
fragment
Cyp2d32-ps mouse see fig. 5 panel A
Cyp2d33-ps mouse see fig. 5 panel A
Cyp2d34 mouse
Cyp2d34-de1b2b7b8b
mouse = u in fig. 5 panel A
Cyp2d35-ps mouse see fig. 5 panel A
Cyp2d36-ps mouse see fig. 5 panel A
Cyp2d37-ps mouse see fig. 5 panel A
Cyp2d38-ps mouse see fig. 5 panel A
Cyp2d39-ps mouse see fig. 5 panel A
Cyp2d40 mouse
Cyp2d40-de7b9b
mouse = t in fig. 5 panel A
Cyp2d41-ps mouse see fig. 5 panel A
CYP2D42 Macaca mulatta
(rhesus monkey)
Cyp2d-se1[1:8:9]
mouse see fig. 5 panel A
CYP2E1 human
CYP2E1 Macaca
fasicularis (monkey)
CYP2E1 Macaca mulatta
(rhesus monkey)
CYP2E1 Mesocricetus
auratus (hamster)
CYP2E1 rat
Cyp2e1 mouse
CYP2E1v1 dog
CYP2E1v2 dog
CYP2E1 sus scrofa
(pig)
CYP2E1 Bos taurus
(bovine)
CYP2E1 rabbit
CYP2E2 rabbit
CYP2F1 human
CYP2F1P human
Cyp2f2 mouse
CYP2F3 goat
CYP2F4 rat
CYP2G1P human
CYP2G1 rat
CYP2G1 rabbit
Cyp2g1 mouse
CYP2G2P human
CYP2H1 chicken
CYP2H2 chicken
CYP2J1 rabbit
CYP2J2 human
CYP2J3 rat
CYP2J3P1 rat
CYP2J3P2 rat
CYP2J4 rat
Cyp2j5 mouse
Cyp2j5-de2b
mouse = q in fig. 5 panel B
Cyp2j5-de9b
mouse = r in fig. 5 panel B
Cyp2j6 mouse
Cyp2j6-de6b
mouse = s in fig. 5 panel B
Cyp2j7 mouse
Cyp2j7-de9b
mouse = w in fig. 5 panel B
Cyp2j7-de9c
mouse = x in fig. 5 panel B
Cyp2j7-de9d
mouse = y in fig. 5 panel B
Cyp2j8 mouse
Cyp2j8-de2b
mouse = t in fig. 5 panel B
Cyp2j8-de9b
mouse = u in fig. 5 panel B
Cyp2j8-de9c
mouse = v in fig. 5 panel B
Cyp2j9 mouse
CYP2J10 rat
Cyp2j11 mouse
Cyp2j12 mouse
Cyp2j13 mouse
Cyp2j13-de8b
mouse = z in fig. 5 panel B
Cyp2j14-ps
mouse see fig. 5 panel B
Cyp2j15-ps
mouse see fig. 5 panel B
CYP2K1v1 Onchorhynchus mykiss
(rainbow trout)
CYP2K1v2 Onchorhynchus mykiss
(rainbow trout)
CYP2K1v3 Onchorhynchus mykiss
(rainbow trout)
CYP2K2 Fundulus
heteroclitus (killifish)
CYP2K3 Onchorhynchus
mykiss (rainbow trout)
CYP2K4 Onchorhynchus
mykiss (rainbow trout)
CYP2K5 Onchorhynchus
mykiss (rainbow trout)
CYP2K6 Danio rerio (zebrafish)
CYP2K7 Danio rerio
(zebrafish)
CYP2K8 Danio rerio
(zebrafish)
CYP2K9 Fugu rubripes
(pufferfish)
CYP2K10 Fugu rubripes
(pufferfish)
CYP2K11 Fugu rubripes
(pufferfish)
CYP2K12P Fugu rubripes (pufferfish)
CYP2K13P Fugu rubripes (pufferfish)
CYP2K14P Fugu rubripes (pufferfish)
CYP2K15P Fugu rubripes (pufferfish)
CYP2K16 Danio rerio
(zebrafish)
CYP2K17 Danio rerio
(zebrafish)
CYP2K18 Danio rerio
(zebrafish)
CYP2K19 Danio rerio
(zebrafish)
CYP2K20 Danio rerio
(zebrafish)
CYP2K21 Danio rerio
(zebrafish)
CYP2K21-de1
Danio rerio (zebrafish)
CYP2K22 Danio rerio
(zebrafish)
CYP2L1 Panulirus argus
(spiny lobster)
CYP2L2 spiny lobster
CYP2M1 Onchorhynchus
mykiss (rainbow trout)
CYP2N1 Fundulus
heteroclitus (killifish)
CYP2N2 Fundulus
heteroclitus (killifish)
CYP2N3 Stenotomus
chrysops (scup)
CYP2N4 Chaetodon
mertensii (butterfly fish)
CYP2N5 Chaetodon
punctatofasciatus (butterfly fish)
CYP2N6 Chaetodon auriga
(butterfly fish)
CYP2N7 Chaetodon
xanthurus (butterfly fish)
CYP2N8 Chaetodon
plebius (butterfly fish)
CYP2N9 Fugu rubripes
(pufferfish)
CYP2N10 Fugu rubripes
(pufferfish)
CYP2N11 Fugu rubripes
(pufferfish)
*CYP2N13 Danio rerio
(zebrafish)
CYP2P1 Fundulus
heteroclitus (killifish)
CYP2P2 Fundulus
heteroclitus (killifish)
CYP2P3 Fundulus
heteroclitus (killifish)
CYP2P4 Fugu rubripes
(pufferfish)
CYP2P5P Fugu rubripes
(pufferfish)
CYP2P6 Danio rerio (zebrafish)
CYP2P7 Danio rerio
(zebrafish)
CYP2P8 Danio rerio
(zebrafish)
CYP2P8-de7,8
Danio rerio (zebrafish)
CYP2P9 Danio rerio
(zebrafish)
CYP2P10 Danio rerio
(zebrafish)
CYP2P10-de9
Danio rerio (zebrafish)
CYP2P-se1 Danio rerio (zebrafish)
CYP2P11 Micropterus salmoides
(large mouth bass)
CYP2Q1 Xenopus laevis
(african clawed frog)
CYP2R1 human
*CYP2R1 Danio rerio
(zebrafish)
CYP2R1 Fugu rubripes
(pufferfish)
CYP2R2P Fugu rubripes
(pufferfish)
CYP2R3P Fugu rubripes
(pufferfish)
CYP2S1 human
Cyp2s1 mouse
Cyp2s1-ie4b
mouse = z in fig. 2 panel B
CYP2T1 rat
CYP2T2P human
CYP2T3P human
CYP2U1 human
Cyp2u1 mouse
CYP2U1 Fugu rubripes
(pufferfish)
*CYP2U1 Danio rerio (zebrafish)
*CYP2U1-de1 Danio rerio (zebrafish)
CYP2V1 Danio rerio
(zebrafish)
CYP2W1 human
Cyp2w1 mouse
CYP2X1 Ictalurus
punctatus (catfish)
CYP2X2 Fugu rubripes
(pufferfish)
CYP2X3 Fugu rubripes
(pufferfish)
CYP2X4 Fugu rubripes
(pufferfish)
CYP2X5P Fugu rubripes
(pufferfish)
CYP2X6 Danio rerio
(zebrafish)
CYP2X7 Danio rerio
(zebrafish)
CYP2X7-de9b
Danio rerio (zebrafish)
CYP2X7-de9c
Danio rerio (zebrafish)
CYP2X8 Danio rerio
(zebrafish)
CYP2X9 Danio rerio
(zebrafish)
CYP2X10 Danio rerio
(zebrafish)
CYP2X11 Danio rerio
(zebrafish)
CYP2X11-de1
Danio rerio (zebrafish)
CYP2X12 Danio rerio
(zebrafish)
CYP2Y1 Fugu rubripes
(pufferfish)
CYP2Y2 Fugu rubripes
(pufferfish)
CYP2Y3 Danio rerio
(zebrafish)
CYP2Y4 Danio rerio
(zebrafish)
CYP2Z1 Fugu rubripes
(pufferfish)
CYP2Z2 Fugu rubripes
(pufferfish)
CYP2AA1 Danio rerio
(zebrafish)
CYP2AA2 Danio rerio
(zebrafish)
CYP2AA3 Danio rerio (zebrafish)
CYP2AA4 Danio rerio
(zebrafish)
CYP2AA4-ie3
Danio rerio (zebrafish)
CYP2AA4-ie8
Danio rerio (zebrafish)
CYP2AA5 Danio rerio
(zebrafish)
CYP2AA6 Danio rerio
(zebrafish)
CYP2AA6-ie6
Danio rerio (zebrafish)
CYP2AA7 Danio rerio
(zebrafish)
CYP2AA8 Danio rerio
(zebrafish)
CYP2AA9 Danio rerio
(zebrafish)
CYP2AB1P human 3q27.1 = old CYP2D31P
Cyp2ab1 mouse
CYP2AC1P human 6p12.3 = old CYP2C57P
Cyp2ac1-ps mouse
CYP2AC1 Rattus norvegicus
(rat)
CYP2AC1 Xenopus laevis
(African clawed frog)
CYP2AC fragment Gallus
gallus (chicken)
CYP2AD1 Fugu rubripes
(pufferfish)
CYP2AD2 Danio rerio
(zebrafish)
CYP2AD3 Danio rerio
(zebrafish)
CYP2AD4 Oryzias latipes
CYP2AD5 Gasterosteus
aculeatus
*CYP2AD6 Danio rerio
(zebrafish)
*CYP2AE1 Danio rerio
(zebrafish)
*CYP2AE1-de9
Danio rerio (zebrafish)
CYP3A1 rat
CYP3A2 rat
CYP3A4 human
CYP3A4-ie1b
human 7q22.1 = u fig. 4 panel A
CYP3A5 human
CYP3A5-de13c
human 7q22.1 = z fig. 4 panel A old 3A51P
CYP3A5-de1b2b
human 7q22.1 = y,x fig. 4 panel A
CYP3A5_v2
human 7q22.1 = alternative transcript = CYP3A5P1 (see note)
CYP3A5_v3
human 7q22.1 = alternative transcript = CYP3A5P2 (see note)
*CYP3A6 rabbit
CYP3A7 human
CYP3A7-de1b2b
human 7q22.1 = w,v fig. 4 panel A
CYP3A8 Macaca
fasicularis (monkey)
CYP3A9 rat
CYP3A10