P450 families and subfamilies (last modified May 16, 2002) D. Nelson 70 animal families with 191 subfamilies 86 lower eukaryote families with 101 subfamiles 52 plant families with 127 subfamilies 77 bacterial families with 123 subfamiles 285 families - 4 (3 CYP51 duplicates and 1 CYP97 duplicate) 281 total P450 families 542 total subfamilies (cyp 51 occurs in all four groups and CYP97 in plants and lower eukaryotes so correcting for that gives 538 subfamiles) CYP1A1 human CYP2A1 rat CYP3A1 rat CYP4A1 rat CYP5A1 rat CYP6A1 Musca domestica (house fly) CYP7A1 human CYP8A1 bovine CYP9A1 Heliothis virescens (tobacco budworm) CYP10 Lymnaea stagnalis (pond snail) CYP11A1 human CYP12A1 Musca domestica (housefly) CYP13A1 Caenorhabditis elegans (nematode worm) CYP14A1 Caenorhabditis elegans (nematode worm) CYP15A1 CYP17 human Cyp18 Drosophila melanogaster CYP19 human CYP20 human CYP21A2 human with congenital adrenal hyperplasia CYP22A1 Caenorhabditis elegans (nematode worm) CYP23A1 Caenorhabditis elegans (nematode worm) CYP24 rat CYP25A1 Caenorhabditis elegans (nematode worm) Cyp26a1 mouse CYP27A1 human CYP28A1 Drosophila mettleri CYP29A1 Caenorhabditis elegans (nematode worm) CYP30 Mercenaria mercenaria (northern quahog, a clam) CYP31A2 C. elegans CYP32 C. elegans CYP33A1 C. elegans CYP34A1 Caenorhabditis elegans (nematode worm) CYP35A1 Caenorhabditis elegans (nematode worm) CYP36A1 Caenorhabditis elegans (nematode worm) CYP37A1 Caenorhabditis elegans (nematode worm) CYP38A1 Suberite domuncula (sponge) CYP39 human CYP41 Boophilus microplus (southern cattle tick) CYP42 C. elegans CYP43 C. elegans CYP44 C. elegans CYP45 Homarus americanus (American lobster) CYP46 human Cyp47a1 Drosophila melanogaster CYP48A1 Trichogramma cacœciae (a parasitoid wasp) CYP51 human Cyp301a1 Drosophila melanogaster Cyp302a1 Drosophila melanogaster Cyp303a1 Drosophila melanogaster Cyp304a1 Drosophila melanogaster Cyp305a1 Drosophila melanogaster Cyp306a1 Drosophila melanogaster Cyp307a1 Drosophila melanogaster Cyp308a1 Drosophila melanogaster Cyp309a1 Drosophila melanogaster Cyp310a1 Drosophila melanogaster Cyp311a1 Drosophila melanogaster Cyp312a1 Drosophila melanogaster Cyp313a1 Drosophila melanogaster Cyp314a1 Drosophila melanogaster Cyp315a1 Drosophila melanogaster Cyp316a1 Drosophila melanogaster Cyp317a1 Drosophila melanogaster Cyp318a1 Drosophila melanogaster CYP319A1 Boophilus microplus (cattle tick) CYP320A1 snail CYP321A1 Helicoverpa zea (earworm) CYP322A1 Perna canaliculus (New Zealand green lipped mussel) CYP323A1 Saccostrea glomerata (Sydney rock oyster) Lower eukaryotes 105 lines CYP51-69 4 alleles 101 unique (189 total) CYP51 Saccharomyces cerevisiae (yeast) CYP52A1 Candida tropicalis CYP52B1 Candida tropicalis CYP52C1 Candida tropicalis CYP52D1 Candida maltosa CYP52E1 Candida apicola CYP52F1 Yarrowia lipolytica CYP53A1 Aspergillus niger CYP53B1 Rhodotorula minuta (a fungi) CYP54 Neurospora crassa CYP55A1 Fusarium oxysporum CYP56 Saccharomyces cerevisiae CYP57A1v1 Nectria haematococca MP VI CYP58A1 Fusarium sporotrichioides (filamentous fungus) CYP59 Emericella nidulans CYP60A1 Aspergillus parasiticus CYP60B1 Aspergillus nidulans CYP61A1 Saccharomyces cerevisiae (yeast) CYP62 Aspergillus nidulans CYP63A1 Phanerochaete chrysosporium (white rot fungus) CYP64 Aspergillus flavus CYP65A1 Fusarium sporotrichioides CYP65B1 Neurospora crassa CYP65C1 Neurospora crassa CYP66 Agaricus bisporus (a mushroom) CYP67 Uromyces fabae (fungus) CYP68A1 Gibberella fujikuroi (a rice pathogenic fungus producing plant CYP68B1 Gibberella fujikuroi (a rice pathogenic fungus producing plant CYP68C1 Fusarium sporotrichioides (fungi) CYP68D1 Neurospora crassa CYP69A1 Gibberella fujikuroi (a rice pathogenic fungus producing plant CYP97 like Skeletonema costatum (a marine diatom) CYP501 Candida albicans CYP502 Coprinus cinereus(homobasidiomycete mushroom) CYP503 Gibberella fujikuroi (rice fungal pathogen) CYP504 Aspergillus nidulans (fungus) CYP505A1 Fusarium oxysporum CYP506 Fusarium oxysporum CYP507A1 Neurospora crassa CYP508A1 Dictyostelium discoideum (cellular slime mold) CYP509A1 Cunninghamella elegans (a fungus) CYP510A1 Lentinula edodes (a basidiomycete fungi) CYP511A1 Botrytis cinerea (a plant-pathogenic fungus infecting over 200 CYP512A1 Coriolus versicolor (a Basidiomycete fungus) CYP513A1 Dictyostelium discoideum (cellular slime mold) CYP514A1 Dictyostelium discoideum (cellular slime mold) CYP515A1 Dictyostelium discoideum (cellular slime mold) CYP516A1 Dictyostelium discoideum (cellular slime mold) CYP517A1 Dictyostelium discoideum (cellular slime mold) CYP518A1 Dictyostelium discoideum (cellular slime mold) CYP519A1 Dictyostelium discoideum (cellular slime mold) CYP520A1 Dictyostelium discoideum (cellular slime mold) CYP521A1 Dictyostelium discoideum (cellular slime mold) CYP522A1 Dictyostelium discoideum (cellular slime mold) CYP523A1 Dictyostelium discoideum (cellular slime mold) CYP524A1 Dictyostelium discoideum (cellular slime mold) CYP525A1 Dictyostelium discoideum (cellular slime mold) CYP526A1 Fusarium sporotrichioides CYP527A1 Neurospora crassa CYP527B1 Neurospora crassa CYP528A1 Neurospora crassa CYP529A1 Neurospora crassa CYP530A1 Neurospora crassa CYP531A1 Neurospora crassa CYP532A1 Neurospora crassa CYP533A1 Neurospora crassa CYP534A1 Neurospora crassa CYP535A1 Neurospora crassa CYP536A1 Neurospora crassa CYP537A1 Neurospora crassa CYP538A1 Neurospora crassa CYP539A1 Neurospora crassa CYP540A1 Neurospora crassa CYP541A1 Neurospora crassa CYP542A1 Neurospora crassa CYP543A1 Neurospora crassa CYP544A1 Neurospora crassa CYP545A1 Neurospora crassa CYP546A1 Neurospora crassa CYP547A1 Neurospora crassa CYP548A1 Neurospora crassa CYP549A1 Neurospora crassa CYP550A1 Neurospora crassa CYP551A1 Neurospora crassa CYP552A1 Neurospora crassa CYP553A1 Neurospora crassa Plants 127 subfamiles CYP51 Sorghum bicolor CYP71A1 Persea americana (avocado) CYP72A1v1 Catharanthus roseus CYP73A1 Helianthus tuberosus (Jerusalem artichoke) cinnamate 4-hydroxylase CYP74A1 Linum usitatissimum (flaxseed) CYP75A1 Petunia hybrida cv. Blue Star CYP76A1 Solanum melongena cv. Sinsadoharanasu (eggplant) CYP77A1 Solanum melongena cv. Sinsadoharanasu (eggplant) CYP78A1 Zea mays (maize) CYP79A1 Sorghum bicolor CYP80A1 Berberis stolonifera CYP81A1 Zea mays CYP82A1 Pisum sativum (pea) CYP83A1 Arabidopsis thaliana CYP84A1 Arabidopsis thaliana CYP85A1 Solanum lycopersicum(tomato) (also Lycopersicon esculentum) CYP86A1 Arabidopsis thaliana (Thale cress) CYP87A1 Helianthus annuus (sunflower) CYP88A1 Zea mays CYP89A1 Vicia sativa CYP90A1 Arabidopsis thaliana CYP92A1 Zea mays CYP93A1 Glycine max (soybean) CYP94A1 Vicia sativa CYP96A1 Arabidopsis thaliana (Thale Cress) CYP97A1 Cicer arietinum (chickpea) CYP98A1 Sorghum bicolor CYP99A1 Sorghum bicolor CYP701A1 Cucurbita maxima (pumpkin) CYP702A1 Arabidopsis thaliana CYP703A1 Petunia x hybrida (petunia) CYP704A1 Arabidopsis thaliana CYP705A1 Arabidopsis thaliana CYP706A1 Arabidopsis thaliana CYP707A1 Arabidopsis thaliana (Thale Cress) CYP708A1 Arabidopsis thaliana (Thale Cress) CYP709A1 Arabidopsis thaliana (Thale Cress) CYP710A1 Arabidopsis thaliana (Thale Cress) CYP711A1 Arabidopsis thaliana CYP712A1 Arabidopsis thaliana (thale cress) CYP714A1 Arabidopsis thaliana CYP715A1 Arabidopsis thaliana CYP716A1 Arabidopsis thaliana CYP718 Arabidopsis thaliana CYP719 Coptis japonica CYP720A1 Arabidopsis thaliana CYP721A1 Arabidopsis thaliana CYP722A1 Arabidopsis thaliana CYP723A1 Triticum aestivum (wheat) CYP724A1 Arabidopsis thaliana CYP725A1 Taxus cuspidata (yew) CYP726A1 Euphorbia lagascae Bacteria 123 subfamilies CYP51 Mycobacterium tuberculosis CYP101 Pseudomonas putida CYP102A1 Bacillus megaterium CYP103A1 Agrobacterium tumefaciens CYP104A1 Agrobacterium tumefaciens CYP105A1 Streptomyces griseolus CYP106A1 Bacillus megaterium CYP107A1 Saccharopolyspora erythraea CYP108 Pseudomonas spp. CYP109A1 Bacillus subtilis CYP110A1 Anabaena sp. (a cyanobacterium) CYP111 Pseudomonas incognita CYP112A1 Bradyrhizobium japonicum CYP113A1 Saccharopolyspora erythraea CYP114A1 Bradyrhizobium japonicum CYP115P Bradyrhizobium japonicum CYP116 Rhodococcus erythropolis CYP117A1 Bradyrhizobium japonicum CYP118 Mycobacterium leprae CYP119 Sulfolobus solfataricus (an archaebacterium) CYP120 Synechocystis sp. (strain PCC6803) Cyanobacterium CYP121 Mycobacterium tuberculosis CYP122A1 Streptomyces sp. CYP123 Mycobacterium tuberculosis CYP124 Mycobacterium tuberculosis CYP125 Mycobacterium tuberculosis CYP126 Mycobacterium tuberculosis CYP127A1 Rhizobium sp. CYP128 Mycobacterium tuberculosis CYP129A1 Steptomyces sp. CYP130 Mycobacterium tuberculosis CYP131A1 Streptomyces peucetius CYP132 Mycobacterium tuberculosis CYP133A1 Erwinia herbicola CYP134 Bacillus subtilis CYP135A1 Mycobacterium tuberculosis CYP136 Mycobacterium tuberculosis CYP137 Mycobacterium tuberculosis CYP138 Mycobacterium tuberculosis CYP139 Mycobacterium tuberculosis CYP140 Mycobacterium tuberculosis CYP141 Mycobacterium tuberculosis CYP142 Mycobacterium tuberculosis CYP143 Mycobacterium tuberculosis CYP144 Mycobacterium tuberculosis CYP145 Nocardioides sp. CYP146 Amycolatopsis orientalis CYP147A1 Myxococcus xanthus Partial missing C-term CYP148A1 Deinococcus radiodurans R1 CYP149A1 Microcystis aeruginosa CYP150A1 Mycobacterium species CYP151A1 Mycobacterium smegmatis CYP152A1 Bacillus subtilis CYP153A1 Acinetobacter calcoaceticus CYP154A1 Streptomyces coelicolor cosmid E6 CYP155A1 Streptomyces coelicolor cosmid 6D11 CYP156A1 Streptomyces coelicolor cosmid E6 gene CYP157A1 Streptomyces coelicolor cosmid 6D11 CYP158A1 Streptomyces coelicolor cosmid 8F11 CYP159A1 Streptomyces coelicolor cosmid F55 CYP160A1 Streptomyces lavendulae LinA homolog. CYP161A1 Streptomyces noursei ATCC 11455 nyst. CYP162A1 Streptomyces tendae nikkomycin CYP163A1 Streptomyces spheroides novobiocin CYP164A1 Mycobacterium leprae cosmid B1788 CYP165A1 Amycolatopsis mediterranei CYP166A1 Amycolatopsis mediterranei rifamycin. CYP167A1 Sorangium cellulosum strain CYP168A1 Pseudomonas aeruginosa CYP169A1 Pseudomonas aeruginosa CYP170A1 Streptomyces coelicolor cosmid 7E4 gene="SC7E4.20 CYP171A1 Streptomyces avermitilis polyketide synthase gene cluster CYP172A1 Campylobacter jejuni CYP173A1 Mesorhizobium loti CYP174A1 Halobacterium sp. NRC-1 CYP175A1 Thermus thermophilus CYP176A1 Citrabacter braakii