84 P450
genes from D. pseudoobscura (RED) and all P450s
from D. melanogaster (BLUE)
Many of
the genes were assembled by students in the MSCI814 bioinformatics class
as
assignment no. 2. The RED genes have been assembled or checked by D. Nelson
<a
HREF="http://drnelson.utmem.edu/msci814.module2.html">Class
Notes</a>
Other
modules can be found by changing the module number to 1 or 3
All D.
melanogaster P450s have been searched.
Note CYP49
N-terminal revised based on comparison to D. pseudoobscura.
CYP12B2
and CYP12E1 N-terminals also revised. CYP318A1 revised
<A
HREF="drosophila.aln.htm">172 sequence alignment and intron
map</A>
Last
modified Feb. 11, 2004.
>4C3
AC014779 73845-80196 also AC008219
MSSKVITSLMAESILLSKVGQVISGYSPITVFLLGSILIFLVVYNKRRSRLVKYIEKIPG
PAAMPFLGNAIEMNVDHD
(1)
ELFNRVIGMQKLWGTRIGINRVWQGTAPRVLLFEPETVE (0)
PILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKI (0)
LTPAFHFKILDDFIDVFNEQSAV
LARKLAVEVGSEAFNLFPYVTLCTLDIVC
(1)
ETAMGRRIYAQSNSESEYVKAVYG (2)
IGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNNNNNNAPD
AYDDVGKKKRLAFLDLLIDASKEGTVLSN (0)
EDIREEVDTFMFEGHDTTSAAISWTLFLLGC
HPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI
(1)
GGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRN
CIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPRD
>CYP4C3
D. pseudoobscura ortholog of Cyp4c3 94% intron 3 missing
MSSKVISSLMAESILLTKMAQVISGYSPITIFLLASIALFLVVYNKRRSRLVKHIEKIPG
PAAMPFLGNAIEMNVDHD
(1)
ELFNRVIGMQKLWGTRLGINRVWQGTSPRVLLFEPETVE
(0)
PILNSQKFVNKSHDYDYLHPWLGTGLLTSTDRKWHSRRKILTPAFHFKILDDFVDVFNEQSAV
LARKLAVEVGSEAFNLFPYVTLCTLDIVC
(1)
ETAMGRRIYAQSDSESEYVKAVYG
(2)
IGSIVQSRQSKIWLQSDLIFRLTADYKLHQSYINTLHGFSNMVIRERKSELALLQDNNNNNNNTPDA
YDDVGKKKRLAFLDLLIDASKDGTVLTN
(0)
EDIREEVDTFMFEGHDTTSAAISWTLFLLGCH
PEYQEQVAEELDSIFGNDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVNI
(1)
GGKLVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNC
IGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPRD
>4d1
AC017770 49988-51720
MFLVIGAILASALFVGLLLYHLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKK
IFEFMETYSKDQVLKVWLGPELNVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLL
VSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSGFSLYDWIN
LCTMDTIC
(1)
ETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARA
EKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERP
LSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSY
ELLNQLHYVDLCVKETLRMYPSVPLLGRKVLEDCEI
(1)
NGKLIPAGTNIGISPLYLGRREEL
FSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVD
FVGDSSEPPVLIAELILRTKEPLMFKVRERVY
>CYP4D1
ortholog with one N-terminal exon found by Michael Mohler 86%
MFLLLGALLA
SGLFVALLVY QLKFKRVIEV ISYMPGPPVL PLVGHGHHFI GKPPHELVKQ
ITEFMSKYAK
DETLKVWLGP ELNVLMANPK DVEVVLGTMR FNDKAGEYKA LEPWLKEGLL
VSRGRKWHKR
RKIITPAFHF KILDQFVDVF ENGSRDLLRN MEMDRLRQGQ TGFNLYDWIN
LCTMDTIC
(1)
ET
AMGVSINAQT NADSEYVQAV KTISMVLHKR MFNIFYRFDL TYMLTPLARA
EKRALHVLHE
FTEKIIVQRR EELIRGGSKD AAAASDDADA DVGAKRKMAF LDILLQSTID
EKPLTNLDIR
EEVDTFMFEG HDTTSSALMF FFYNVATHPE AQKKCFEEIS SVIGQDKSTP
VTYELLNKLH
YVDLCIKETL RMYPSVPLLG RRVVEECEI (1)
N
GKRIPAGTNI GISPLYLGRR
EELFSEPNSF
KPERFDVVTS AEKLNPYAYI PFSAGPRNCI GQKFAMLEIK AIVANVLRHY
HIDFVGDTTE
PPVLIAELIL RTKDPLLFKL QDRVY
>4d1
alt. splice AC017770 48817-51720
MWLLLSLVLLLAIIALEMRRFLRNMRTIPGPLPLPLLGNAHIFLGLTPAEACLKIGELAE
RHGDTFGLFLGPSYSVMLFNPRDVERVLGSSQLLTKSQEYSFLGRWLNEGLLVSNGRKWH
RRRKIITPAFHFRILEPYVEIFDRQSLRLVEELALRISRGQERINLGEAIHLCALDAIC
(1)
ETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLH
QFTEKIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQSTVDERPLSNLDIREE
VDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYV
DLCVKETLRMYPSVPLLGRKVLEDCEI
(1)
NGKLIPAGTNIGISPLYLGRREELFSEPNIFKP
ERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPP
VLIAELILRTKEPLMFKVRERVY
>CYP4D1
ortholog with alternative splice exon 1 found by Michael Mohler 80%
upstream
exon 1
MWLSLVFGAVGTVLVLGLFSWLPFCRRRRRISELAELLPGPKPW
PLLGDAHLFFGLSPAEACLMMGQLAEKY
GDTFKLRLGPCFSVMFFHPSDVEQVLSSTQLVDKADEYDFLARWLNEGLLVSTGRKWHKR
RKIITPAFHFRILEQYVEIFDRQTHQFLSNLDLARGKDDNLVNLGHAVHLCALDVIC
(1)
ETAMGVSIN AQTNADSEYV QAVKTISMVL
HKRMFNIFYR
FDLTYMLTPL ARAEKRALHV LHEFTEKIIV QRREELIRGG SKDAAAASDD
ADADVGAKRKMAFLDILLQSTIDEKPLTNLDIREEVDTFMFEGHDTTSSALMFFFYNVAT
HPEAQKKCFE
EISSVIGQDK STPVTYELLN KLHYVDLCIK ETLRMYPSVP LLGRRVVEEC
EI
(1)
NGKRIPAG
TNIGISPLYL GRREELFSEP NSFKPERFDV VTSAEKLNPY AYIPFSAGPR
NCIGQKFAML
EIKAIVANVL RHYHIDFVGD TTEPPVLIAE LILRTKDPLL FKLQDRVY
>4d2
AC017770 comp(32267-34028)
MLGVVGVLLLVAFATLLLWDFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPE
(1)
QIMDFVKKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGR
KWHGRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIA
(1)
ETAMGTKINAQKNPNLPYVQAVND (2)
VTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAI
KVMHDFTENIIRERRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTIDGAPLSDED
IREEVDTFMFEGHDTTTSAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGE
LKFMENVIKESLRLHPPVPMIGRWFAEDVEI
(1)
RGKHIPAGTNFTMGIFVLLRDPEYFESPD
EFRPERFDADVPQIHPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKLLRHFELLPLGPEPR
HSMNIVLRSANGVHLGLKPRA
>4D2
ORTHOLOG 79% TO 4D2
MLALVVFLVALTTVLVWDYFWRKRRNDILHYMPGPRGLPLVGNALMYRGLDAE
(1)
QIMGFVSKNRNKYGPLYKVWVLNQLAVFSTDPHDIEFILSSQQHITKNNLYELLHCWLGTGLLMSTG
KKWHSRRKIITPTFHFKILEQFVEIFDQQSAVMVGQLQQRADGKTAINIFSVVCLLALDIIA
(1)
ETAMGTKIQAQMSPNLPYVQAVTD
(2)
VTNIMTTRFIHAWQRIDWLFRLVHPGMAKRQDSAIKVMHDFTENIIKQRRQALVSAGKQEKEKEEIK
EDDDLGQKRRMALLDVLLQSTIDGASLSNDDIREEVDTFMFEGHDTTTSAISFCLYEISRH
PQVQQLLVEEIHEVLGVDRHRPVTLRDLGELKYLENVIKESLRLHPPVPMIGRWFNEDVEI
(1)
RGKRIPAGTNYTVGIFVLLRDPEYFESPDEFKPDRFDSTSPQTHPYAYIPFSAGPRNCIG
QKFALLEMKSTISKLLRNFELLPLGPEPRPAMNIVLRSANGVHLGLQPRSVLAS*
>4d8
AC017388 comp(37292-39859) also AC010557 AC010112 AC010113
MLLFLLVVLLFGAGWIIHLGQADRRRKVANLPGPICPPLIGAMQLMLRLNPK
(1)
TFIKVGREYVLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGK
VWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIA
ETAMGTKIYAQANESTPYAEAVNE (2)
CTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIR
TMQEFTIKVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMSTVDGRPLTNDEIR
EEVDTFMFEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELK
YMECVIKESLRMYPPVPIVGRKLQTDFKY
(1)
THSVHGDGVIPAGSEIIIGIFGVHRQPETFP
NPDEFIPERHENGSRVAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLPMGQR
VECIVNIVLRSETGFQLGMRKRKHN
>4d8
orth D. pseudoobscura Van Alstine
and We Liu 79%
MLLLVLVLLLVAVGWLVHRGQAERRRAVSNLPGPMCPPLLGALHIMSSMNPK
(1)
TFIKVSGENMRKYG
PLQRVWILNRLLIMSADSEINEQLLSSQEHLVKHPVYRVLGKWLGNGLLLSDGKV
WHQRRKIITPTFHFSILEQFVEVFDQQSNVCVERLAPRANGQTFDVYRPVCMAALD
IIAETAMGTKIHAQAAESTPYAEAVNE
(2)
CTALLSWRFISVYLQVELLFTLTHPYMKWRQTQLIRTMHDFTTKVIEERRRTLEEQQ
GSKLSPSPDDDVGRKRRMALLDVLLLATVDGRPLTNDEIREEVDTFMFEGHD
TTTSALSFCLHVLARHPQVQEKMLEEILRVIGTDRKRPVTIRDLNEMKYLECVIKESLRL
YPPVPLVGRKLQTDFKY
(1)
SHSKYGDGVIPAGSEFLIGIYGMQRNKNEFAQSEEFIPERHENGERFSPFTFIPFSA
GPRNCIGQKFAQLEMKMMLAKIVREYELLPLGEPVECVINIVLRSD
TGFQLGMRRRNDTQ*
>4d14
AC017770 35699-37438 missing intron 3
MYLELFAILLATALAWDYMRKRRHNKMYAEAGIRGPKSYPLVGNAPLLINESPK
(1)
TIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLISQ
GKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMD
IIAETAMGVKINAQLQPQFTYVQSVTT (2)
ASAMLAERFMNPLQRLDFTMKLFYPKLLDKLND
AVKNMHDFTNSVITERRELLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTIDGAPL
SNDDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMK
LLGELKYLECVIKESLRLFPSVPIIGRYISQDTVLDGKLIPADSNVIILIYHAQRDPDYF
PDPEKFIPDRFSMERKGEISPFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLPL
GEEVQPVLNVILRSTTGINCGLKPRVY
>4d14
D. Pseudoobscura K. Earhart 79%
MFVELLVLLLTVALVWDYLVGRKHKRLFDRAGITGPKAWPLVGNAPLMINESPK
(1)
TVFDLQWRLIQTHGKNVRCQILQDRGFMTADPKMIEAIMSSQQTIQKNNLYGLLVNWLGDGLLLSK
GKKWFRRRKIITPAFHFKILEQFVEVFDQQSAIMAKNLYDRADGKTVINMFPVACLCAMD
IIAETAMGVKINAQLQPNFPYVQSVKT
(2)
ASGMLAERFVNPAQRLDISMRLFFPSAFAKLSA
NIKAMQDFTNNVISERRDLLQKSISDGTYETTNASPLDDVGQKRRMALLDVLLQSSIDGA
PLSNEDIREEVDTFMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVLGDEKDAPVN
IQLLGELKYLECVIKESLRLFPSVPIIGRHIVEDTLL
(1)
DGKLIPAKTDVMILIYHSQRDPDYFPEPNKFVPERFSPERKGEINPFAYTPFSAGPRNCIG
QKFAMLEMKSTISKMVRHFELLPLGEDVQLVLNLILRSTTGINVGLKPRVY
>4d20
AC019509 comp(19731-21636)
MWLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAE
(1)
NIIGWVGEKFDKYGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRPFLNDGLLVST
GRKWHARRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVIT
(1)
EAAMGVQVNAQNDPDFPYIKALKS (2)
VVYIQPDRMFRFSRRYNWLFPLAAPLLHRQLLSDIRVMHDFTDKVISERRETVRRAKADGTYRPL
(1)
SLGDAEIGSKSQMALLDILLQSSINNQP
LSDADIREEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQ
AQLQDLKYLDCVIKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANY
FPDPLSFRPERFLEDQEQGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLP
LGEELKPMLNFILRSASGINVGLRPRKALR
>4D20
ORTHOLOG 74% TO 4D20 same as below Contig1058_Contig8213.5
MLLLTLAFGALAVLLTWDFVRKRQRAATLERSKISGPLSLPVLGNGLQALDLGAE
(1)
NIVDWVEESFRLYGKTFRMWILGESLIYTKDLKYFEAILGSTTLLQKGQLYKFLRPFLNDGLLLSV
GKKWHARRKVFTNAFHFNVLGHYVDIMDRQAAVMVEKLRQVADGETTVDMLPYVSLAALDVIT
(1)
EAAMGVQVNAQSDSEFPYVQALKS
(2)
VVYIQSDRMFRFLQRYDWLFRLTCPVLRSKLLKDVRVMHDFTDKVIRERRAAVEQAKADGSYRPL
(1)
SLGDPEVGRKSQMALLDILLQATIEGQP
LSDADIREEVDTFMFEGDDTTSSGVSFALYAIARHPQVQARIYRELLQVLGRDPSTPVTQ
AKLQELKYLDCVIRETLRLYPAVPAVGRYTSKEIQIGGQTIPANTSIYLVLYFAHREAEF
FPDPLAFKPERFLDRADSEDRETFAYLPFSAGPKNCIGQKFAMLEMKALVSKVLRCYELL
PRGPEVKPMMNFILRSSTGMNVGLRPRRSP*
>4d21
AC020004 55466-57280
MWILLGIAVLIMTLVWDNSRKQWRVNTFEKSRILGPFTIPIVGNGLQALTLRPE
(1)
NFIQRFGDYFNKYGKTFRLWILGECLIYTKDLKYFESILSSSTLLKKAHLYRFLRDFLGDGLLLST
GNKWTSRRKVLAPAFHFKCLENFVEIMDRNSGIMVEKLKNYADGKTCVDLFKFVSLEALDVTT
(1)
ETAMGVQVNAQNEPNFPYTKALKS (2)
VVYIESKRLASVSMRYNWLFPLAAPLVYRRLQK
DIAIMQDFTDKVIRERRAILERARADGTYKPL
(1)
IMGDDDIGGKAKMTLLDILLQATIDNKP
LSDVDIREEVDVFIFAGDDTTTSGVSHALHAISRHPKVQECIYEELVSVLGPDPDASVTQ
TKLLELKYLDCVIKETMRLHPPVPILGRYIPEDLKIGEITIPGNTSILLMPYYVYRDPEY
FPDPLVFKPERWMDMKTTSNTPPLAYIPFSSGPKNCIGQKFANLQMKALISKVIRHYELL
PLGADLKATYTFILSSSTGNNVGLKPRTRVK
>Contig1058_Contig8213.5
74% to 4D20 same seq as 4D20 ortholog aligned
with
4d21 in melanogaster/pseudoobscura alignment. Probably no ortholog to 4d21.
>4e1
AC020402 44580-46698
MWIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPT
(1)
EILNRFFGWWHEYGKDNFRYWIGYYSNIMVTNPKYME (0)
FILSSQTLISKSDVYDLTHPWLGLGLLTSTGSKWHKHRKMITPAFHFNILQDFHEVMNENST
KFIDQLKKVADGGNIFDFQEEAHYLTLDVICDTAMGVSINAMENRSSSVVQAFKD (2)
ITYTIKMRAFSPWKRNKYLFHFAPEYPEYSKTLKTLQDFTNEIIAKRIEVRKSGLEVGIKADEFSR
KKMAFLDTLLSSKVDGRPLTSQELYEEVSTFMFEGHDTTTSGVGFAVYLLSRHPDEQ (0)
EKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQRLYPSVPFIGRFTEKDYVI
(1)
DGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQ
PERFDREKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGY
ISTTLGLQPAEKKSRDAHNHKYDPILSASMTLKSENGLHLRMKQRLVCDST
>4e1
D. pseudoobscura ortholog of 4e1 T. Liu INTRON 4 MISSING 73% to 4e1
MWFALYLVLALPLLWLAYLELKSLRRRRVLNKFKGPKVLPVVGNAHQLGRTPP
(1)
EILGQMFEWWYQHDKDNFRYWIGYYPNLMVTRTKYFE
(0)
FILSSQTLISKAEVYSLMQPWLGLGLLTSTGSKWHKHRKMITPSFHFNVLQDFHEVMNEKS
TKFIKHLKNVSGGGSIVDFQEQAHFLTLDIICETAMGVSINAMENQDSELVQAFKD
(2)
MCYNIKVRTFSSWKRNPTLYQFASDYPAYCKTL
KTLQDFTHDVIEKRLNAHKEGTVLASHGDEFSRKKMVFLDTLLSATVDGRPLTSQELYEE
VSTFIFAGHDTTTSAISFTLYLVSRHQDDEQR
KLFEEQRDVMGDSGLDREATFQEISEMKYLDLFIKEAQRVYPSVPFVGRYTEKDYVI
(1)
DGDLVPKGTTLHMGIFMLGYDDRVFKEPHKFRPQRFEEEKPGPFEYVPFSAGPRNCIGQKFAL
LEIKTVVSKIIRHFEVLPALDELASKDGYIRTTLGLPPTEKRKRDLQQHKYDPILLVAMS
LKSENGIYLRLKERF*
>4e2
AC020402 41848-44099
MWFVLYIFLALPLLLVAYLELSTFRRRRVLNKFNGPRGLPLMGNAHQMGKNPS
(1)
EILDTVFSWWHQYGKDNFVFWIGTYSNVLVTSSKYLE (0)
FILSSQTLITKSDIYQLTHPWLGLGLLTST
GSKWHKHRKMITPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLD
VICDTAMGVSINAMENRSSSIVQAFKD (2)
MCYNINMRAFHPLKRNELLYRLAPDYPAYSRTL
KTLQDFTNEIIAKRIEAHKSGAVSTNAGDEFTRKKMAFLDTLLSSTIDGRPLNSKELYEE
VSTFMFEGHDTTTSGVSFAVYLLSRHQDEQ (0)
RKLFKEQREVMGNSELGRDATFQEISQMKY
LDLFIKEAQRVYPSVPFIGRFTEKDYVI
(1)
DGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFELEKPGPFEYVPFSAGPRNCIGQKFALLE
IKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKSENGLYIRLKERH
>4e2
pseudoobscura Ajit Narang INTRON 4 MISSING 86% to 4e2
MWFVLYLFLALPLLLVAYLELSTFRRRRALNKFKGPSRLPIVGNAHQAGKNPT
(1)
EILDQVFSWWHQYGKDNFRFWIGSYSNLIITNHKYLE
(0)
FILSSQTLITKSDIYNLTHPWLGLGLLTST
GSKWHKHRKMITPSFHFNILQDFHEVMNENSTKFIKQLKQVAAGDSIFDFQNETHYLTLD
VICDTAMGVSVNAMENRSSSIVQAFKD
(2)
MCYCINMRAFHPFKRNDLFFRLAPDYPAYCKTL
KTLQDFTNNIIEKRIKAHKDGTVSASQGDEFSRKKMAFLDTLLSSTIDGRPLTTQELYEE
VSTFMFEGHDTTTSGVSFAVFLLSRHKDEQRKLFDEQREVMGDSGMDRDATFQEISEMKY
LDLFIKEAQRVYPSVPFIGRYTEKDYII
(1)
EGDLVPKGTTLNLALVMLGYNDRVFKDPHKFR
PERFELEKPGPFEYVPFSAGPRNCIGQKFALLEIKTVVSKIIRHFEVLPALDELASKDGY
ISTSLGYPPEERKKRDLLRHKYDPLLSAVLTLKAENGLFIRLKERH
>4e3
AC020324 73117-75125
MWLAVLALLVLPLITLVYFERKASQRRQLLKEFNGPTPVPILGNANRIGKNPA
(1)
EILSTFFDWWYDYGKDNFLFWIGYSSHIVMTNPKQLE (0)
YILNSQQLIQKSTIYDLLHPWLGHGLLTSF
GSKWHKHRKMITPSFHFNILQDFHEVMNENSAKFMTQLKKASAGDTIIDFQEHANYLTLD
VICDTAMGVPINAMEQRDSSIVQAFRD (2)
MCYNINMRAFHPFKRSNRVFSLTPEFSAYQKTL
KTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGRPLTRQEIYEE
VSTFMFEGHDTTTSGVSFSVYLLSRHPDVQ
(0)
RKLYREQCEVMGHDMNRSVSFQEIAKMKYL
DLFIKEAQRVYPSVPFIGRYCDKDYDI
(1)
NGSIVPKGTTLNLALILLGYNDRIFKDPHHFRP
ERFEEEKPAPFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDGRL
NTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRLRERRS*
>D.
pseudoobscura ortholog of Cyp 4e3 M. Nooh 81%
MWLAVLALLALPLLVLVYFELRASRRRRMLKVFNGPAPVPVLGNANRVGNTPA(1)
EILATIFDWWQEYGKDNFVFWIGYTPHLAVTNPKYLE(0)
YILNSQSLIQKSTIYELLHPWLGYGLLTSH
GSKWHKHRKMITPSFHFNILQDFHEVMNENSTKFIAQLRRDAAGDSIIDFQDHAHYLTLD
VICDTAMGVPINAMEHRNSAIVQAFKD(2)
MCLSVNMRAFHPFKRSNRIYSLSPEYAAYQRTL
KTLQDFTYDIIEKRVETLQAGQNSSSADSSSPRKKMAFLDTLLSSTVDGRPLTRQEIYEE
VSTFMFEGHDTTTSGVAFAGYLLSRHPEAQ
(0)
QRMYQEQCNVMGSELDRDATFQEIAQMKYLDLFIKEAQRVYPSVPMIGRYADKDYMI
(1)
NGTLVPKGTTINLALVLLGYNDRIFKDPHHFRP
ERFEEEKPGPFEYVPFSAGPRNCIGQKFALLELKTVISKLVRSFEVLPAVDELLSTDGQL
NTYLGLSPAEKQKREAGRHKYDPILSAVLTLKSDNGLHLRLRERRH
>4g1
AC020093 comp(33262-34932) no introns
MAVEVVQETLQQAASSSSTTVLGFSPMLTTLVGTLVAMALYEYWRRNSREYRMVANIPSP
PELPILGQAHVAAGLSNAEILAVGLGYLNKYGETMKAWLGNVLLVFLTNPSDIELILSGH
QHLTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVA
RMGLEAGKSFDVHDYMSQTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVK
LLYRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPA
SKKEGLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIMDEVNTIMFEGHDT
TSAGSSFALCMMGIHKDIQAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLY
PPVPLIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMA
NRHYYSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLE
NGFNVSLEKRQYATVA
>4G1
ortholog NO INTRONS 93% IDENTICAL TO 4G1
MTVDTVQETLQHAATSTSGLGFSPMLTTLVGTIVALGLYEYWRRNTREYRMVANIPSPPG
LPLLGQAHMVAGLSNAEILNVGLGYLNKYGETMKAWLGNVLLVFLTNPNDIELILSGHQH
LTKAEEYRYFKPWFGDGLLISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKSVVGRM
GLETGKSFDVHDYMSTTTVDILLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLL
YRLDSIYKFTKLREKGDRMMNIILGMTSKVVKDRKQNFQEESRAIVDEVQAVSTPATKKE
GLRDDLDDIDENDVGAKRRLALLDAMVEMAKNPDIEWNEKDIIDEVNTIMFEGHDTTSAG
SSFALCMMGIHKDIQEKVFAEQKAIFGDNMLRDCTFADTNEMKYLERVILETLRLYPPVP
LIARRLDYDLKLASGPYTVPKGTTVIVLQYCVHRRADIYPNPTKFDPDNFLPERMANRHY
YSFIPFSAGPRSCVGRKYAMLKLKVLLSTIVRNYIVHSTDTEADFKLQADIILKLENGFN
ISLEKRKYATVA
>4g15
AC013897 comp(8972-10574 and 5306-6643) two pieces
MEVLKKDAALGSPSSVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDVIGPAS
(1)
SVFRTVIRKSAPFEHIAKMWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLIST
(1)
GQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLRAEDGRTFDCHDYMSEATVEILL
(1)
ETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLT
RYYKEQGRLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALERER
EQNGGVDQTPSTAGSDEKDREKDKEKAS
PVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQN
GALITDTEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQ (0)
DTLEMKYLERCLMETLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHR
NPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRSCV
(1)
GRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQPRTS
>4G15
ortholog (94%) intron #4
missing, black region does not match
MEVLKKDAAMGSPSSVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDVIGPAS
(1)
SVFKTVIRKSAPFEHIAKMWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLIST
(1)
GQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLRAEDGRTFDCHDYMSEATVEILL
(1)
ETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLT
RYYKEQGRLLSIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALERER
GQEQKQEQKQEQAEMGSAGGGKAAGEGT
PVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQN
GALITDTEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQEIQDRVIAELDGIFGDSQRPATFQ
DTLEMKYLERCLMETLRMYPPVPLIARELQEDLKLNSGDYVIPRGATVTVATVLLHR
NPKVYTNPNVFDPDNFLSERQANRHYYAFVPFSAGPRSCV
(1)
GRKYAMLKLKILLSTILRNYRVYSDLSESDFKLQADIILKREEGFRVRLQA
>4p1
AC018129 comp(67703-69662)
MIILWLILALSALLYWLHRANKDYHILSFFTKRIRLKDGTPVEIIAPIAKGKTIFGNTLDLYGRDH
(1)
AGVFNYSRERAKEMGTSYIEYVFGKAIYNIIDADSAENVLNHPNLITKGLVYNFLHPFLRTGLLTST
(1)
GKKWHARRKMLTPTFHFNILNQFQEIFK (2)
TESQKFLLQFEGQDEVTITLHDVIPRFTLNSIC
(1)
ETAMGVKLDEMAEKGDRYRENFSQIEECFIRRLSNPLLWGDKLFEM
FAAKDFASALDVVHRFSSEIIAKRRDLLKDELDKSSSTADDDG (2)
FVSKKRFAMLDTLIYAE
KDGLIDHIGICEEVDTLMFEGYDTTSIGLIFGLMNMSLNPDKQELCYQEIQEHID
(1)
DDLSNLDVGQLNKLKYLEYFMKETTRLFPSVPIMGREAVQETELANGLILPKGAQITIHVFDIHR
NAKYWDSPEEFRPERFLPENVQDRHTYAYVPFSAGQRNCI
(1)
GKKYAMQEMKTLMVVLLKQFKVLKAIDPQKIVFHTGITLRTQDKIRVKLVRRT
>D.
pseudoobscura ortholog of Cyp4p1 Jie Shen 72% to 4P1
MIVFLLTVALCALVLWLYRINKDYYILAFFSRRVRTKDGRPVESILPSPKGRTIFANCFDMYGKDL
(1)
AGVFSYSRELSQRLGESYLEYGMGVPLLNIIDAENAENILNHPKLITKSLVYDFLQPALRTGLLTST
(1)
EKKWHARRKMLTPTFHFNILGQFQEIFR
(2)
AESLKFVQQFQSQDESIVSLSDLIPRFTLNSIC
(1)
ETAMGVKLDEMAEKGDRYREGIHMIEMSFIRRLSNPLLWNKTIYNW
FAAKTYDAFLKTVHEFSSEIIAKRRILLEEELEHRRSTQTADDDI
(2)
FGSRKKRFAMLDTLICAEKDGLIDHAGICEEVDTLMFEGYDTTSIGLIFSLMNMSLYPEKQELCYKEIEEHID
(1)
DSFDNLDNNQLSKLKYLEYFIKETMRLFPSVPIMARQTIQETELANGLILPERSQITIHVFD
VHRNPKYWDSPNEFRPERFLPENCQNRHTYAYIPFSAGQRNCI
(1)
GQKFAMQEMKTLIVVLLKKFRILPLIDPKTIVFNVGITLRTQNNIQVKLVRRK
>4p2
AC018129 comp(70087-72192) revised 9/11/2000
MMICLLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLGKDT
(1)
DQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPFLRTGVLTAT
(1)
EKKWHTRRSMLTRTFHLDILNQFQEIFI (2)
AESLKFVSQFQGQNEVVVSLKDRISRFTLNSIC
(1)
ETAMGIKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDDCVY
NMFTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDI (2)
CVIRKKRFAMLDTLICAEKDGLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHIL
(1)
DDLSNLNLSQLSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHV
FDIHRNPKYWESPEEFRPERFLPQNCLKRHPYAYIPFSAGQRNCI
(1)
GQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQVGITLRFKNKIKVKLVRRNCV
>CYP4P2
ORTHOLOG FOUND BY B. WU 78% to 4p2
TMIVVLWLTVALCVIVHWLYRVNKDYYIMAFFSRRVRTKDGRPVESIVPMIKGRTVFANCFDLLGKDT
(1)
DQVFTHLRQLAKNSGDSYLQYSMGFSNFNVIDAHNAANILNHPNLITKGVIYNFLHPFLRTGVLTAT
(1)
EKKWHARRKMLTRTFHFNILEQFQEIFQ
(2)
AESLKFVQQFQSQDESIVSLSDLIPRFTLNSIC
(1)
ETAMGVKLDEMAEKGDRYREGIHMIEMSFIRRLSNPLLWNKTIY
NWFAAKTYDAFLKTVHEFSSEIIAKRRILLEEELEHRRLTQTADDDI
(2)
FVSRKKRFAMLDTLICAEKDGLIDHAGICEEVDTLMFEGFDTTSIGLIFSLMNMSLYPEKQELCYKELEEHID
(1)
DNFDNLDHNQLSKLKYLEYFIKETMRLFPSVPIMARQTIQETELANGLILPERSQIT
IHIFDVHRNPKYWDSPNEFRPERFLPENCQNRHTYAYIPFSAGQRNCI
(1)
GQKFAMQEMKTLIVVLLKKFRILPLIDPKTIVFNVGITLRTQNNIQVKLVRRN*
>4p3
AC018129 comp(65426-67385) revised 9/11/2000
MLILWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGKDH
(1)
SGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLHPFLRTGLLTST
(1)
GKKWHARRKMLSPTFHFNILNQFQEIFI (2)
TESLKFLEQFKGNDEAIISLNEVIPRFTLNSIC
(1)
ETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKM
FAEKDYASALDVVHGFSSEIIAKRRDQLNDEIDSRGNTQTAEDEL (2)
FTSKKRFAMLDTLILAEKDGLIDHIGICEEVDTLMFEGYDTTSIGLMFGLMNMSLYPEEQEKCYQEIQANID
(1)
DELNILNIGQLNKLKNLEYFIKETMRLFPSVPAMGRETTRETELSNGLILPKGSQIFVHVFDI
HRNPEYWDSPEEFRPERFLPENSQNRHTYAYIPFSAGQRNCI
(1)
GQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVNS
>CYP4P3
L. Hunt 66% to 4p3
MITLWLTVALCVVIHWLYQVNKDYYILAFFSRRVYTRDDRPVESLVPSPKGRTIFAHCFDLYGKDN
(1)
AGVFKFTRDLSKTLGKSYVRYVVGMPIYNVIDAETAEMILTDQKSLIGKGCVYNFLHPALKTGLLTSQ
(1)
GDKWHARRRMLTPTFHFNILGQFQEIFQ
(2)
AESLKFVQQFQSQDENIVSLSELIPRFTLNTIC
(1)
ETAMGVKLDEMADKGDRYRESFHMIEKSFVRRLSNPFLRSTTIYN
LFVAKEYAPFLKVVHDFSSEIIAKRRILLEEELEHRRSTQTADDDI
(2)
FVSRHKRFAMLDTLICAEKDGMIDHAGICEEVDTLMFEGYDVSSITLIFTLMNMSLYPDKQELCFKEIQEHIE
(1)
DDFSNLDINQMSKLKYLEYFIKETMRLFPPIPLMGRQAVQETELANGLILPSGTQIHIHTF
DIHRNPKHWDSPNEFRPERFLPENSQNRSVYAYIPFSAGQRNCI
(1)
AQKFAMQEMKTLMTVILKKFEIQPLVDPNSIVFHVGITLRIKNHIRV
>4s3
AC018488 comp(98620-101060) also AC015418 AC018487
MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKG
(1)
EILNWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESW
HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICET
AMGIKKHAQLQSDSEYVQAVQS (2)
ICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHD
ETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREE
VDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKESMPYLEAVIKETLR
IYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQ
MHPFAFAAFSAGPRNCI
(1)
GQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNG
IRLRILPRDENGTTA
>D.
pseudoobscura ortholog of Cyp4s3 L. Yang
MNTWALMAFALWALFLRYLPQILTFLRLQRFAKTLPGPSVSELIANVKKG
(1)
EILNWLKELRERHGPVFRIWFGKDLMVMFSDPEDIRQLLGNNSLLYKSRNYALLEPWLGKGLLTNGGESW
HRRRKLLTPGFHFRILSEFKEPMEENCRILVSQLKERANGEAFDIYPYITLFALDAICET
AMGIKKHAQLQSESEYVKAVQT
(2)
ICRVMHKQSFSFWQRLNIFFKYTQAGQERDGALRVLHD
ETNRVIRLRREQLVKERQLQQRTEAAQDDVGSKRRLAFLDMLLLTQLEGGDELSDRDIRE
EVDTFMFEGHDTTSSAIAFALSLLSKHSEVQQRAYEEARDLEGREKESMPYLEAIIKETL
RLYPSVPFFSRKVFEDIQVGKHTIPKGASVNCLIYMLHRDCNNFPDPERFDPDRFYLNEK
QMHPFAFAAFSAGPRNCI
(1)
GQKFAMLELKCSLSSLLRSFQFMPDEDHQPIPLAELVMKSGNGVRLRIQPRSQH*
>4aa1
AC020355 comp(15477-16779) and AC007579 comp(38212-38842)
MHLRLLSPPQLERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPFLGNCMLVTDKD
(1)
LMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVF
FYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV
GTEINIAKYVNNCVLDILN
(1)
EAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLL
DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRD
FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMT
DLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY
PDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPV
TGKTTIAATFRITLRASGGLWVRLKERDHPLIAH
>4aa1 S. Yu 79%
MQFYTRMTV
(frameshift)
PQLERATRTELCSILALLVISLSIYLFYAHLDTYLRSVILSLRLSGPPTLPILGNCLLIKDKD
(1)
LMRNQAAKAFDLYGSLVRIWVLFFPFFVVLQPEDLQVILSSQKHTNKVFIYQLMHNFL
GDGLITSSGLKWSTHRRLIQPAFHLSLLEKFIGTFVDASQSLYESVGASAVGTDINIVSI
VNNCVVDILN
(1)
EAVLGVPIKKKGLDLVKIDESPFRQGKLMIPTRFSHPWLLFDGIYHWTKL
ANDELNQKKRLHDFTRQMIKIRREILANTGNNNAERKCLLDYMIEISESNPDFTEQDIVN
EACTFMLAGQDSVGGAVAFTIFLLAQNAECQEQCHEELERIFDYSDRAPTMSDLREMRYL
EMCIKEALRLYPTVPLIARKLGEEVRLSDHTLPAGSNIFICPYATHRLNNIYPEPEKFNP
ERFSPENSKDRHPYAFIPFSAGPRYCIGNRFAIMEMKTIVSRLLRSFQLLPVAGKTTFDV
SYRITLRASGGLWVRLKPRDHPISQTRDSDCFGL*
>4ac1
AC017771 comp(24745-26507)
MWIALLGIPILLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTP
(1)
ASVFNFVRESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQSTKLITKNVVYELIRPFLGDGLLIST
(1)
DHKWHSRRKALTPAFHFNVLQSFLGIFK (2)
EECKKFLNVLEKNLDAELELNQVIPPFTLNNIC
(1)
ETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFF
VYGDYRKHLQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADG
QIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVENLPEDSDDISMF
QFNKLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHF
PKPDLFQPDRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPA
TQLEDLTFENGIVLRTQENIKVKLSKRVK*
>4AC1
D. pseudoobscura Y. Zhuang deletion at heme 82%
MLIALLGTPLLLLGVWLLLQRLNRTYFILSLTRRVRTEDGSPLESKVAVMPGTTRFGNNLDVLNCTP
(1)
SSLFNFLRDSAAKAQGRNFLWYFLFAPMYNVIRAEEAEEIFQSTKLITKNVIYELLRPFLGEGLLIST(1)
DQKWHSRRKALTPAFHFNVLQSFLAIFK(2)
EECNKLIKVLDKKVDGELDLNQVIPQFTLNNIC
(1)
ETALGVKLDDMSEGNQYRRAIHAIEEVLIQRVCNPLMFYNW
YFFLIGDYRKQVQNLRIVHDFSSRIIERKRQQFKRKQLGVVDDFGKKQRYAMLDTLLAAE
AEGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEEVQERCLEEVSTLPEDTDSI
SVFQFNELVFLECVIKESLRMFPSVPFIGRTCVEECVVNGLILPKDTQISIHIYDIMRDP
RHFPNPHEFQPERFLPENTVDRHPFAFVP
16
aa deletion of heme signature region
EIKVLLAAVLRNFRILPVTRLEDLTFENGIVMRTQQNVKVKLVRR*
>4ac2
AC017771 comp(22220-24109) revised 9/8/2000
MFLEVLFAAPLVIFIFRKLWAHLNRTYFILSLCKRIRTEDGSLLESKIYVAPSKTRFGNNFDLVNFTS
(1)
ESIFNFMRDASAKAKGRNYLWYFFHAPMYNIVRAEEAEEILQSSKLITKNMIYELLKPFLGEGLLIST
(1)
DQKWHSRRKALTPAFHFKVLQSFLIIFK (2)
EECNKLVKVLHQSVNMELELNQVIPQFTLNNVC
(1)
ETALGVKLDDLSEGIRYRQSIHAIEEVMQQRLCNPFFYNIVYF
FLFGDYRKQVNNLKIAHEFSSNIIEKRRSLFKSNQLGQEDEFGKKQRYAMLDTLLAAEAD
GQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEIKYLPDDSDDISV
FQFNELVYMECVIKESLRLFPSVPFIGRRCVEEGVVNGLIMPKNTQINIHLYEIMRDARH
FSNPKMFQPDRFFPENTVNRHPFAFVPFSAGQRNCIGQKFAILEIKVLLAAVIRNFKILP
VTLLDDLTFENGIVLRTKQNIKVKLVHRENK
>Contig3635_Contig7816.24
75% to 4ac2 74% to 4ac1
MFELLLGVPLIVLLCCVLLRRLNRKYFVLSLCKRLQAEDGSPLESKIAVMPGRTRFGNNFDLLNFTP
(1)
STVFNFMRDSCANARGRNYLWYFFGSPMYNVIRAEEAEEIFQSTKLLTKNVVYDLLRPFLGEGLLTST
(1)
DQKWHARRKALTPAFHFNVLQSFLAIFK
(2)
EECHKLVKVLHESVESEALVLNQVIPQFTLNNIC
(1)
ETALGVKLDDMAEGFQYRESIHAIEAVILQRICNPFLYNSLYFYLY
GDYRKHIDSLKIAHDFSSSIIERRRRDIKRKELGVVDDFGKKQRYAMLDT
LLAAEADGQIDHQGICDEVNTFMFEGYDTTSTCLIFTLLMLSLHKDVQER
CLEEVSALPEDTDSISVFQFNELVFLECVIKESLRMFPSVPFIGRQCTEE
CVVNGLVMPKDTHINIHIYDIMRDPRHFPNPNAFQPERFLPENTVDRHPF
AFVPFSAGQRNCIGQKFAILEIKVLLAAVLRNFKILPDTRFEDLTIENGI
VLRTQQKVKVKLVQRVG*
>4ac3
FROM DROSOPHILA
MWIALLGSSLLIGALWLLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTP
(1)
ANIFSYIRESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIFQSTKITTKNMSYELIRPFLGDGLLISI
(1)
DQKWHTRRKTLTPAFHFNILQSFLSIFK (2)
EESKKFIKILDKNVGFELELNQIIPQFTLNNIC
(1)
ETALGVKLDDMSEGNEYRKAIHDFEIVFNQRMCNPLMFFNWYFF
LFGDYKKYSRILRTIHGFSSGIIQRKRQQFKQKQLGQVDEFGKKQRYAMLDTLLAAEAEG
KIDHQGICDEVNTFMFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMF
QFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHF
PKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLPA
TQLEDLTFENGIVLRTQQNIKVKFEARVK
>NO
4AC3 ORTHOLOG FOUND. This fragment
most like last half of CYP4P exon 1
YIMAFFSRRVRTKDGRPVESIVPVPKGRTIFANCLDLYGKDH
(1)
>4ad1
AC020402 comp(36565-39829)
MFLIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPA
(1)
EYPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQ (0)
NILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYAPAFERS
AIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVC
(1)
ENATGQDSSSLNGETSDLHGAIKD (2)
LCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNR (0)
IISQRRHQLAAENTCQQGQPINKPFLDVLLTAKLDGKVLKEREIIEEVSTFIFT (0)
GHDPIAAAISFTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNRNPIDI
(1)
NGTKVAKCTTVIMCLIAMGYNEKYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRRCI
(1)
AEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGIQIRLRKR
>4AD1
of D. pseudoobscura R. Aziz 87%
MFLIAIAIILATILVFKGVKIFNYIDHMAGIMEMIPGPTPYPFVGNIFQFGLKPA
(1)
EYPKKVLQYCRKYDFQGFRSLVFLQYHMMLSDPAEIQ
(0)
NILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKHQKLYMPAFERSAIEGYLRVVHR
TGGKFVQKLNELTETLEVFDAQELVAKCTLDIVC
(1)
ENATGLVSNSLNDEPSDLHGAIKD
(2)
LCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRREIYR
(0)
IITQRRQQLADENTCGERTKKINKPFLDVLLAAKLDGRALKEREIIEEISTFIFA
(0)
GHDPVAAAISFTLYTLSRHTEIQQRVFEEQQRIFGQDLTAEADIGRLDQM
RYLELVIRETLRLYPSVPLIARTNRKPIDI
(1)
NGTKVAKRTTVIMCLIAMGYNEKYFEEPCVFRPERFETAGADVGIEAFKSVPFSAGPRRCI
(1)
AERFAMYQLKALLSQLLRNFEILPPVNGLSSGINDHSQVECVPQSEYDPVLNIRVTLKSENGIQIRLGKRAFVE*
>4ae1
old 4e4 AL009194 16210-17867
MLVVLLVALLVTRLVASLFRLALKELRHPLQGVVPSVSRVPLLGAAWQMRSFQPD
(1)
NLHDKFAEYVKRFGRSFMGTVLGHVVMVTAEPRHIDALLQGQHQLKKGTMYFALRGWLGDGLLLS
RGKEWHTMRKIITPTFHFSILEQFVEVFDRQSSILVERLRTLSYGNEVVNIYPLVGLAAL
DIITETAMGVNVDAQGADSEVVHAVKD (2)
LTNILATRFMRPHLLFPHLFRLCWPSGFRKQQA
GVICLHEFTNGIIEQRRRLLAREANQDKPTKPHALLDTLLRATVDGQPLTDKQIRDEVNT
FIFEGHDTTTSAVSFCLYLLSRHEAVQQKLFEELRMHYGQDLFRGVILSDFATLPYLSCV
VKESLRLYPPIPAVARCLEKDLVI
(1)
DEGYIPVGTNVVVLLWQLLRDEAIFTDPLVFQPERHLGEEAPRLSPYSYIPFSAGPRNCIG
QKFALLEMKTMVTKVIRHYQLLPMGADVEPSIKIVLRSKSGVNVGLRPRLY*
>4AE1
ortholog Stephanie Nance 71%
MLMALLLTMALTLIVAWLLQLALREMRHPLRGFVPSVSRVPLVGAAWQMRSFQPD
(1)
NLHEKFAEYVERFGRSFMASVCGQVIMVTAEPSHVDALLHSQKQLRKSSIYGALRGWLGNGLLLS
QGEQWHGMRKIITPTFHFSILEEFVEVFDKQSQLLVERLQPLSNGGMVAINIYPYVGLAA
LDIITETAMGVCVNAQLDADSAVVQAVKA
(2)
VTNTLATRFMRPHLLPPLLFRLCWPSGFRKQ
QEGIKCLHLFTNSIIEQRRQLLRRENAPGEPVARDRRNALLDTLLRATVDGQPLTDKQIR
DEVNTFIFEGHDTTTSAISFCLYLLSRHAAVQERLFDEVKGHFGRELDRCVVYSDFAALP
FLNCVVREALRLYPPIPALGRCLETDLAV
(1)
EGGRIPAGTNVILLLWQLLRDEMLFADPLIFRPERHLSNKATSKKGAYSNIPFSAGPRNCIG
QKFAMFEVKTMIIKMLRNFILLPIGPDVEPSIKIVLRSRNGVHFGLRPRVY*
>6a2
AC007549 comp(100072-101661)
MFVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYY
NKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN
LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMA