34 C. elegans carriers revised Nov. 21, 2000 >Z75955 34% to X76115 33% to carnitine/acylcarnitine carrier rat sequence 77A in alignment MYADFIAGWAAEQLYFLLSITAKVIASYKNKVFERLRFLYDLKI SILKKHLNINARYLFTVIPGGAGLLVGHPLDTVKARLQTMNIYKGIVDCMVKTMKQES VYGLYKGMFVPFISTGALHSLLFAGYGAGLKFLNPGDSNVMARKDLPMSDILIASICG TLVQVGPVIPVELLKTKLQVQRENIGHFSKHSRNLYAGPLECARETVRAEGVRGLFKG GSVVFCRDNIGYLFYIPVYEGLSRYFRSHNLENTWTQLFAGGCAGVSGWISVCPLEVV KNRIQADKSHKTLSPKEMTLKIYREDGLRAFYRGGWAISLRGFVVNAVIFVVYENTYS FFD >Z70310, AL023841 sequence 71A in alignment MSFSLEMPQMLPAPRDCYAVPGKPGHSEPLTVVGWEHMDLKLFY PSALFSSWSIRTALYPLAVLRSQLQLQKQNTVYRSTFHAYSDISKREGFRGLYRGFWI TVPQIGCSFIYSTIFEKCRAVLHEQGIQSVGGVAAVAGGLASFATQSIFVPTDIIAQY MMIYKNTDKLTAGHDKSVIDGVRNHVKNGSGLGTSVIKAIYKTDGILGFYRGFWASTA VYVPQMLTFWPSYYWMLGLFNKVPYRTLHPATNRSLLFDQAVAATLGGVISTVATNPM ELFRVRLQVHRGSYSKTLETMLRDEKTAVFTKGLTPRIIANSMYSGLVVVGYEIVKRL CAKEEYKHRVKW >U23525, X76114 dicarboxylate carrier sequence 71 in alignment MAEDKTKRLGRWYFGGVAGAMAACCTHPLDLLKVQLQTQQQGKL TIGQLSLKIYKNDGILAFYNGVSASVLRQLTYSTTRFGIYETVKKQLPQDQPLPFYQK ALLAGFAGACGGMVGTPGDLVNVRMQNDSKLPLEQRRNYKHALDGLVRITREEGFMKM FNGATMATSRAILMTIGQLSFYDQIKQTLISSGVAEDNLQTHFASSISAASVATVMTQ PLDVMKTRMMNAAPGEFKGILDCFMFTAKLGPMGFFKGFIPAWARLAPHTVLTFIFFE QLRLKFGYAPPVKA >AF043695 with C-term ext. 26% to Z72511 sequence 102A in alignment MVGYHPEAINEPLTSAEYSEAGLASGIVTRMIIQPLDVLKIRFQ LQEEPIRGKKSGKYKGVMQSIFLITREEGAHAFWKGHIPAQGLSATYGLVQFSSFEWL SQQAAKVIPADNQSVRSTSDFACGALSGCLAMTAAMPLDVIRTRLVAQKAGHAVYTGT MHAVKHIWEKEGIAGYFRGWVPSVVQIAPFTGMQFALYNCFMDLWPFNGYESAGALFS GAMAGTVAKTVLYPLDMVRHRLQMNGFERAGFGKTSNYSQGLFKTIGMVVKNESWYGL FKGLWPSQIKAAANSGWRIVSIHASAFTVSKLVFGTAADRTSNSRLLIGGILLCSTSS IGLGIGKSLQRIIYFLNYFSVHQRSAGWVPATKLIATWFDDASYATMFSVLGCGSTFA GMIVPLFKTSYWRTIEFNSGIVMLLFAIICKKWIITEDAIRKEVKPLKKEDMEEENTI GVKKIMKSSVMWHIALVYFFSMEMRTICETWAPLYLNEKKMSADGFQFLYELGGLAGT MISGLVLERLAGKMGVDPSRRLLGIIFTVIMMIVGCGVFKFEEYSSVLGFLTGFFVNG SINIWCLIGSQAGTKSVAGTVSAFISFIASVGSIFAGSPLAHLIATFSFHVFTILFVT QIVFVLSISSLQIPLRMEAFSEKKTQ >AF003384 31% to U80836 oxogl. sequence 190A in alignment MSSAVTSTSDSTAPGNSQTFKKIATKVFIQQVLPLRTSIIYFQY FLSCTAALVAETVTYPLDITKTRLQIARNKFTKGGIWMVQVTYDIIRREGAMALWTGV APAITRHYIYTGIRMGAYEQIRLLTFNKEVEKSFPLWKSMLCGAFSGLIAQFAASPTD LVKVQMQMEGLRRLQKQPLRYTGATDCFRSLYRTQGFFGLWIGWMPNCQRAALLNMAD IATYDSVKHGLIDNFELKDNWLTHAVASACAGLAAAIVSLPSDVVKTRMMDQIRHELD AKMMHKKNTHVDLYKGVVDCYIKIIKNEGFFSLYKGFLPSYIRMAPWSLTFWVSYEEI RKWTGASSF >X76115 "c1" CEL04F8 DIF-1 sequence 77 in alignment MSDVLLNFIAGGVGGSCTVIVGHPFDTVKVRIQTMPMPKPGEKP QFTGALDCVKRTVSKEGFFALYKGMAAPLVGVSPLFAVFFGGCAVGKWLQQTDPSQEM TFIQNANAGALAGVFTTIVMVPGERIKCLLQVQQAGSAGSGVHYDGPLDVVKKLYKQG GISSIYRGTGATLLRDIPASAAYLSVYEYLKKKFSGEGAQRTLSPGATLMAGGLAGIA NWGVCIPADVLKSRLQTAPEGKYPDGIRGVLREVLREEGPRALFKGFWPVMLRAFPAN AACFFGLELTLAAFRYFGIGGHPTPSTEVVPLPHDE >X76116, Z49070 "c2" sequence 115 in alignment MFVDREAAIHFIGGAVGGTTGTAITCPLEVVKTRMQSSRGLDAQ SGPSTSSGSNSSKSSTSSSSTKSNGIFKSVVSQRNGFGSNFRGGQLALERIFNNGSLA ALSKANLFNQFQNPSTTSLVQYCVRNLSTSSTPPQPPTAARRGTIVIKYITQVIKTEG IGALYKGLIPNLVGVAPSKAVYFYTYSTSKRFWNESEVLIPNSAIVHMVSAGSAGFVA ASAVNPIWLVKTRLQLHQGHIGIWQMIKRVYHREGFKGFYKGVTASYAGVSETMIQFC IYEYFRGVLLSDANEMDKRKMDFLNFMVAGGSAKFIACVVAYPHEVVRTRLREETGKS RGFFKTLYQLYKEGYPAMYRGLSVQLMRTVPNTAITMGTYEFVVYMLHHL >U58750 sequence 86 in alignment MDIDELELLQEEREEQPIRYLPKVLNGGISGIVGVSCVFPMDLV KTRLQNQKGTSKYTGIADCFKKSWQAGAPGRLNQIKGMYQGASVNIFLITPEKAIKLV ANDFFRHALMKDHDERLSTPRGMIAGASAGFCQVVITTPMELLKIRMQQSSDKVKATK LIWNLLTKDGGVRALYKGLGPTMARDVSFSAMYFPLFAYLDGLGPRKKDDSGDAVFWA SFVSGLTAGATASLSVTPLDVVKTRIQTGGSNYNGIFHAFYRILADEGVKALFKGAIC RMMVMAPLFGIAQTVYYVGSAEKILGLEKGSRV >U49830, Z81586 similar to PO4 carrier sequence 172 in alignment MGLFHDVFDAAQKNGIVIPSAPSVVRTAKCSSAATSVAAPIEFG SSQFYAMCALGGSLSCGLTHFAITPLDIVKCRIQVNKEKYGSMVQGFKVTIAEDGVRG LARGWAPTFIGYSAQGLGKFGFYEVFKNIYSSALGEENAYIWRTSIYLAASASAEFFA DIFLAPMEAVKVRMQTSPTAPTTLRACAPMIYKQEGLTGFFKGLPPLWTRQIPYTMMK FTCFEKTVELLYQYVVPKPRAQCSKSEQLAVTFTAGYIAGVFCAVVSHPPDVLVSKLN QDSNASVGSLVKQLGFKGLWGGLGPRIIMVGTLTALQWFIYDSFKVAMNLPRPPPPRM PESLKKKLGIPGTTEVAPVAEKVAAPEKSAKSEKPGKVDKKQEKKEKKEKKAKKEEAV >U23412 sequence 150 in alignment MHESGEPTTATGDASANHFKDGIIDLLAGTAGGIANVYAGQPLD TVKVKVQTFPNLYSNWIVCLKDTYKLDGIRGLYAGTLPALAANVAENAVLFTAYGYCQ KTIATLNGLEDVRQMTPLENAFSGSLAAVFAATVLCPTELVKCKLQAAREMKKKCTPF SVCRDIMKDTGVRGFFVGMTPTLAREVPGYFFFFGAYETCRFLLTDEGQKKEEIGLVK TAMAGSVGGMALWTSIYPADVVKSRMQVTGGGTFMSTLGAVVKENGIRGLYKGLLPTN LRTCFASGCLFVAYEETRKFFHYVL >X76113, Z14659, M89246, Z68341 PO4 carrier sequence 171 in alignment MSVFSQLAESSKQNPFSLPVRSGNCASAVSAPGQVEFGSGKYYA YCALGGVLSCGITHTAIVPLDLVKCRIQVNPEKYTGIATGFRTTIAEEGARALVKGWA PTLLGYSAQGLGKFGFYEIFKNVYADMLGEENAYLYRTSLYLAASASAEFFADILLAP MEATKVRIQTSPGAPPTLRGCAPMIYKAEGLTGFYKGLPPLWMRQIPYTMMKFACFEK TVEALYQYVVPKPRAECSKAEQLVVTFVAGYIAGVFCAIVSHPADTVVSKLNQDSQAT AGGILKKLGFAGVWKGLVPRIIMIGTLTALQWFIYDSVKVALNLPRPPPPEMPASLKA KLAAQQ >Z22180 Citrate carrier sequence 155 in alignment MSGIQPVPGAKPLSMWQQYGPSEKTVRGIVIGGITGGIEICITF PTEYVKTQLQLDERSATPKFRGPIDCVKQTVNGHGFFGLYRGLSVLLYGSIPKSSFRF GTFEYLKSQAADERGNLSPVMRLLCGLGAGLSEAVFAVTPMETVKVKFIHDQGLAQPK YKGFVHGVGCIVKAEGLGGIYKGVTATMAKQGSNQAIRFFVMETLKDWYRGGDNTQPI SKPIVGLMGAVAGAASVYGNTPIDVVKTRMQGLEAKKYKNTLDCAMQIWKKEGFFAFY KGTVPRLSRVCLDVGITFMIYDSIIEFLDVYWKKQQ >Z49068 sequence 116 in alignment MKIPDLTNYEHLIGGLCGGVTSTVVCHPFDLLKIRFSANEGSSL RPQYSSYADAVRKIVRVEGVRGLYQGWTPSLIGASLSWGLYFQWYNSLRTKIYENFST GSKLANNLISGCISGSAIMCITNPIWLTKTRLCLQYENQQSKKYAGMMDCLKKTVKQE GFFGLYRGFVTGVIGTTHGAVQIAAYSWIIDKRCQSQGLPKDSFLSQTDYVIASSTSK VLATTITFPYQVLRTRMQDHNTDSRGVWKTTLKTIHNEGIGGLWKGCLIANVRQLPAA VVTFLTYENVKRLVGMTKQI >Z68160 PET8 homolog sequence 141 in alignment MPSEEGSVVRWLVCGATAGLAVDIGLYPLDTIKSRMQSKQGFIA AGGFKDIYRGMISVLVGSAPGAAIFFLTYKYINGQMKQVIEERNALVDAVSASLAEIA ACAVRVPTELCKQRGQVNKNERLTLICKEIMETKGIRGFYRGYGSTVAREIPFSIIQF PIWEALKRAVANKKESGRCSPLEGAACGSVAGFIAAGLTTPLDVAKTRIMLTKNGPAP GILSTLKEVYTSNGVRGLYSGVVPRVMWISGGGFVFFGAYETAMHFTKFLD >Z74028 sequence 173 in alignment MNPFSDVMRKALCSSPQSPSSNSTGLVPFGSPKFYVLCGMGGSI CCGFTHLVITPLDIVKCRMQVDPLKYTGVVQGFKVAVAEDGVRGLARAWAPTTIGYSA QGFGKFGYYEIFKNVYGSMLSEENAYTYRSWVYLAAASSAEFFADFFLAPFEAVKVRM QTSSTAPKTMRECMPMIYKKEGMYGFFKGLPPLWTRQIPYTTVKFVCFERIMELMYTH VVPKPRAECTKMEQLLVTFSAGYLAGILCAVASHPPDVIVSQLNQDPNATLTSTAKKL GLKGMWAGLGARIIMIGTITAMQWFIYDGWKVVMGIPRPPPAEMPDSIRKKLENVQRK >Z78542 AL008880 sequence 88 in alignment MNGGLAGIIGVSCVFPIDLVKTRLQNQTVGADGKLQYSGIADCA KQTWRSGGASTLAKFRGMYSGSGVNILLITPEKAIKLVANDFFRHKLAKEGEKQLSVG RGMLAGGLAGMFQISVTTPMELLKIQMQDQGRTLKPGQQKLSATQLTMKLVKENGIAA LYKGLSSTLARDVTFSVIYFPLFAYLDSLAPRKPDGSGDAVFYGSFLAGLTSGAASSF CVTPLDVIKTRMQTINKGANEIVYKNIPDAFVTIFKNEGPKALFKGAACRMMVMAPLF GIAQTVYYIGVAEKILGIQKATHV >U64842 ADP/ATP carrier sequence 21 in alignment MSLERVFLKKTLAEFFCQNFVKSLQAVSC phase 1 intron VSRDDVIKFSKDFMAGATAAAISKTVIAPVERVKLILQ phase 0 intron LQNSQTTLALENRYKGIVDCFIRVPREQGFLSFWRGNWV NILRSCSQESLGLSFKEFFRKYSLEGVDPKTQHSRWLVG phase 1 intron NLVAGGGSGCATLATIYPLDFIRTRLAIDLGKRKS phase 0 intron DREFTGMFDCAKKIIKSDGVPGLYKG phase 2 intron LIPSLQYMIIYRGAYYGLFDTTAPYMNSDGKMTFTEAFLVG QVVTLIAAMTSYPLDTVRRRLMMGAGKKTLPFNNTISCIK phase 0 intron YIYTKEGPKAFFHGALVNAIRGTGAALVLAIYNELQKYM >U80931 *like ADP/ATP carrier only 3 amino acid diffs with Z68218 These are probably different genes since the nucleotide sequences Are only 92% identical and the first intron is different in length and sequence between the two. This seq is more like the EST sequences, except at aa 2 where the EST shows F. Not in alignment MSGGGDSKPIDKKKEDKKGFDTRKFLIDLASGGTAAAVSKTAVA PIERVKLLLQVQDASLTIAADKRYKGIVDVLVRVPKEQGYAALWRGNLANVIRYFPTQ ALNFAFKDTYKNIFQKGLDKKKDFWKFFAGNLASGGAAGATSLCFVYPLDFARTRLAA DVGKANEREFKGLADCLVKIAKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKMVF TADGKKLNFFAAWAIAQVVTVGSGILSYPWDTVRRRMMMQSGRKDVLYKNTLDCAVKI IKNEGMSAMFKGALSNVFRGTGGALVLAIYDEIQKFI >Z68218 *like ADP/ATP carrier only 3 amino acid diffs with U80931 These are probably different genes since the nucleotide sequences are only 92% identical and the first intron is different in length and sequence between the two. Sequence 36 in alignment MTGG phase 1 intron GDSKPIEKKKEDKKGFDTRKFLIDLASGGTAAAVSKTAVAPIERVKLLLQVQ DASLTIAADKRYKGIVDVLVRVPKEQGYAALWRGNLANVIRYFPTQALNFAF KDTYKNIFQKGLDKKKDFWKFFAGNLASGGAAGATSLCFVYPLDFARTRLAA DVGKANEREFKGLADCLVKIAKSDGPIGLYR phase 2 intron GFFVSVQGIIIYRAAYFGMFDTAKMVFTADGKKLNFFAAWAIAQVVTVGSGI ISYPWDTVRRRMMMQSGRKDVLYKNTLDCAVKIIKNEGMSAMFKGALSNVFR GTGGALVLAIYDEIQKFI >Z68882 similar to ADP/ATP carrier sequence 37 in alignment MSTSASLSPAALQKRSDAQKFAIDLLIGGVSASVSKTVVAPIERVKILLQ phase 0 intron VQYSHKDIPADKRYNGIIDAFVRVPKEQGFVSFWRGNMTNVIRYFPTQAFNF AFNDLYKSILLKNMKREN phase 0 intron NVLSYSVRTLVSGGLAGCSSLCIVYPLDFIRTRLSADINH HTKREYKGLVDCTMKTVKNEGFSALYRGFAISLQ phase 0 intron TYFIYRSVYFGLYDAIRNTINTDKKKLPFYASFAIAQ phase 0 intron GVTVLSSYLTYPWDTVRRRMMVKGQLSTSKA FSAARKIVHEEGVRGLYKGALANIFR phase 2 intron SAGGALVMALYEEIHKHM >Z82059, X76112 seq 35 in alignment MSKEKSFDTKKFLIDLASGG phase 1 intron TAAAVSKTAVAPIERVKLLLQ phase 0 intron VQDASKAIAVDKRYKGIMDVLIRVPKEQGVAALWRGN LANVIRYFPTQAMNFAFKDTYKAIFLEGLDKKKDFWK phase 2 intron FFAGNLASGGAAGATSLCFVYPLDFARTRLAADIGKANDREFKGLAD CLIKIVKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKMVFASDG QKLNFFAAWGIAQVVTVGSGILSYPWDTVRRRMMMQSGRKDILYKNT LDCAKKIIQNEGMSAMFKGALSNVFRGTGGALVLAIYDEIQKFL >Z68220 incomplete see align under citrate carrier MRTTSRALMYGLYDEFQISLKCPRSPPNSSFSICHAQAAFLSGV CEAMLCPLERVQVLLQTTIFHDKFKNTLHTFNRLRDYGYREYYRGFSVILIRNSLSNT IFFTLRDPLKQKIVGIPQAGRLPESLQQLIGDFVAGSLLGATISTAFFPLGVIKNHMQ AKVGVKYESGFKVFRDVWQLRNRSLRGLYLGVHLNFTRSLVAWGIINSMYGILRRALA PFE My translation of this gene extends to the N-terminal no start Met found sequence 156 in alignment **KLEFRAKITLESSRKSADPATTVAH RNHLDFLAGWGAGCIETCILYPSNKIIFRQQLHGFHVKDAIQQIKLEGVGKLYRGLLPPLI MRTTSRALMYGLYDEFQISLKCPRSPPNSSFSICHAQAAFLSGVCEAMLCPLERV QVLLQTTIFHDKFKNTLHTFNRLRDYGYREYYRGFSVILIRNSLSNTIFFTLRDPLKQKI VGIPQAGRLPESLQQLIGDFVAGSLLGATISTAFFPLGVIKNHMQAKVGVKYESGFKV FRDVWQLRNRSLRGLYLGVHLNFTRSLVAWGIINSMYGILRRALAPFE* >Z49207 sequence 40 in alignment MASTSATLDVLETSKKCLAGSAAAAISKTTTAPFDRVKLVLQLQ RQSEFAMAEYNGIRDCISKIRLEQGAMALWRGNGAGVARCLPNHTLNFAFRDIYRNTL LKNVDRNESFGKFLAGTFVSGGLGGATTLFMLYPFDFARTRLALDVKKDGSRKYKGMV DCLKKIKASEGVASWYKGLSSALQFVIASRAIFFGIFDSIRTSVEDPKSLNFAACWAI AQISITTSGMVCYPLDTVRRSMMMQSGKQIKQYTSTKDCWKTLYKKDGINGFYRGALT NSLRSTGGALIITFYYEFSKYM >Z50873 sequence 48 in alignment MSVTAESPSLRGGSILENKQELIDLKNIGEHARTVQPFKTSKHQ PLIQGSVSKEAAIATHSALHFDLTPEKEKKIRDMYDRLDADNDGSIDIRDLTQALSLQ AHIPASVAPKLLERMKSEHSDRVTYADFTNYVIAHEARLAEVFDKIDLNSDGEVDMAE IKSYCKEMGVNLDDQKAMSIVKKMDQSGSSSVNLNEFQDFMLLYPSTDMRDMVDFWRH NLVCTCLESNSRFRTQNFQIIDIGEDGQVPEDFTPQELLSGVWWRHLVAGGVAGAMSR TCTAPFDRIKVYLQVMYLHLLFHIMFLKALQVNSTKTNKLGVVSCVHLLHAEGGIKSF WRGNGINVIKIAPESAMKFMCYDQIKRWMQEYKGGAELSTIERLLAGSSAGAISQTAI YPMEVMKTRLALRRTGQLDKGMFHFAHKMYTKEGIKCFYKGYLPNLLGIIPYAGIDLT VYESLKSMYTKYYTEHTEPGVLALLACGTCSSTCGQLASYPLALVRTRLQARAISPKN STQPDTMVGQFKHILQTEGFTGLYRGITPNFMKWFSKCSSAHFNMRLKFINVPAKKNS GCFIILAFLIKSATLIPDSSH >AF003141 sequence 37A in alignment MTTKEGFDYRKFLVDLASGGTAAAISKTAVAPIERVKLLLQVSD VSETVTADKKYKGIMDVLARVPKEQGYAAFWRGNLANVLRYFPTQALNFAFKDTYKKM FQEGIDKNKEFWKFFAGNLASGGAAGATSLCFVYPLDFVRTRLGADVGKGVDREFQGL TDCFVKIVKSDGPIGLYRGFFVSVQGIIIYRAAYFGMFDTAKTLYSTDGQKLNFFTTW AIAQVGTVGSGYLSYPWDTVRRRMMMQSGRKDILYKNTLDCVRKIVKNEGITALYKGG LSNVFRATGGALVLTIYDEIQHLI >Z72511 sequence 49 in alignment MINKNEQTESTSGAAEQKEDDEEQYVQLSSLGEYKDEVTPLLSP KHVPLVLGKVTKEAAIATHSALHGGMSEEKERQIRDIYDRLDIDNDGTIDIRDLTLAL KHETPHIPANLAPVIMSKMSPDDEGRVDFYSFSSYVLENEQKLAEMFADMDRNHDGLV DVVEMKNYCKDIGVPLDDHKAQHIVNKMDQTGSASVDLKEFQEFMMLYPSSDLKDIVD FWRHNLIIDIGEDSQIPEDFSQQEMQEGIWWRHLVAGGAAGAVSRTCTAPFDRIKVYL QVNSSKTNRLGVMSCLKLLHAEGGIKSFWRGNGINVIKIAPESAIKFMCYDQLKRLIQ KKKGNEEISTFERLCAGSAAGAISQSTIYPMEVMKTRLALRKTGQLDRGIIHFAHKMY TKEGIRCFYKGYLPNLIGIIPYAGIDLAIYETLKRTYVRYYETNSSEPGVLALLACGT CSSTCGQLSSYPFALVRTRLQALSITRYSPQPDTMFGQFKYILQNEGVTGFYRGITPN FLKVIPAVSISYVVYEKVRTGLGVPVCSRGGLEDIHQFLPCSIHSIIQFFFFPRTFLL TISGRSLRVKPVWRSHFSKFNK >Z79755 sequence 61 in alignment MPHDSNEGKQRPSVVLSLSAGAIAGALAKTTIAPLDRTKIYFQV SSTRGYSFRSAIKFIKLTYRENGFFALYRGNSATMARVVPYASMQFAAFEQYKKLLKV DENGSRTPVKRYITGSLAATTATMITYPLDTAKARLSVSSKLQYSSLKHVFVKTYKEG GIQLLYRGIYPTILGVIPYAGSSFFTYETLKIMYRDHRGEVENSYYRMLFGMLAGLIG QSSSYPLDIVRRRMQTGRIPSGWSPLRALIHIYHTEGLKRGLYKGLSMNWLKGPIAVG VSFTTYEKVLELVGHLKR >Z75532 sequence 79 in alignment MSALLDLFAGSLGGAAGVLAGHPLDTVKVRLQTQSGPTPQYRGT FHCFKLIVQKEGFRGLYKGMSSPLLSLSAINAIVFGVHGGTCRQMEDPDSITSHFVGG CAAGMAQSVIAAPTERIKLLLQIQDDKAHTKFNGPIDATKQLLRTHGLKSLTRGFLAT VARDAPAFGVYFASYEWMARSMCKDGETSTLSSGQLLFAGGTAGMLSWLFNYQTDIIK SRFQADNSYKSYMHCIKQTYLERGYRGFFVGLNSALIRAFPSNAATFFTVEWTYRILL DFNVIDNVTKEAEKICAESQLLPFEELTLSYLIL >U00052 sequence 87 in alignment MSFDHLLTSSKRRELLQNLGIGHGSDVFSTGLFRKAECNAETAI SQRSIPRANPDHLRPIFDRFATKEIKGKKLMTPEDFIRGYLGLYTEENYNKETVRLLA SAADTTKDGDISFEEFCAFEALLCSPDALYLTAFELFDRNASDTISCDEFEAVIRHTQ PLHDQDFDFSSEFIKRYFGADKQRNVNYHSFCQLLHDFYEEQGIQAFKRYDKNGNGTI SSLDFQQIMTTVKGHLLTDFVRHNLIAVSGGASGHKVTFPYYAAFNSLLAKMELIKRV YVSTTRKIGKSKIFRFSETIKKYNKNKVEILFHLSELNHPGRKTLCLKDIQAIDPERL KRVSQMDRLINIKAVHHKDDRGVGTAFLESAYRFLLGSVAGACGATAVYPIDLVKTRM QNQRTSGSFVGEVMYKNSLDCFKKVVKFEGLLGLYRGLLPQIVGVAPEKAIKLTMNDY MRDKFTKDGKIPLYGEIIAGGTGGMCQVVFTNPLEIVKIRLQTAGEVQQAGKKIGVFT VLKELGFLGLYKGSRACFLRDIPFSAIYFPAYAHAKLASADEDGMNSPGTLFASAFIA GVPAAGLVTPADVIKTRLQVAARAGQTTYNGVIDCARKLIKEEGPMSLWKGTAARVCR SSPQFAVTLLTYEVLQRLFYVDFAGSRPTGSELATTKTIQDESSTNPDHVGGYKLAAA TFSGIEHKFGLFLPKFETSK >Z81577 sequence 99 in alignment MEKLKEGGRQITAGGSAGLVEVCLMYPLDVVKTRLQLGQQDKGM MDCVVKTLKNEGIGGFYKGILPPILAETPKRATKFFTFEQYKIAFTHSEIPLPVTMSF AGLFSGLTEAIVICPFEVVKVRLQADRNSSVKEQRSTASMAREIYRNEGFGTSGLYRG LGATLGRHGAWNMVYFGLYHSCREVIPDAKVGYESRVGG KTAIAVRQIEFDFRQFAGL PICRKFLFSANCQFAICRKCSEGFFIRRKLKPKKTQEISFKLLIASGYFPPKGFFLQ QNPTSNLIGR IALGFTAGSLASIFNIPFDVAKSRIQGPQPDPFTRKYSGTMQTISLVYK EEGFGALYKGLLPKVMRLGPGGAVMLIVYDEVYSWLQKNT CDS join(6385..6436,7369..7502,7987..8094,9330..9440, 9527..9864,10385..10651,11305..11419) Contains a repeat element RQVAGLPICRKFLFSANCRFAVCWISICRKFLGGFFIRRK At the end of 5th exon that Is seen about 850 times in C. elegans. This translation is in error, Since this element should be removed. Ortholog of 90B human seq. An alternative corrected sequence is given below MEKLKEGGRQITAGGSAGLVEVCLMYPLDVVKTRLQLGQQDKGM MDCVVKTLKNEGIGGFYKGILPPILAETPKRATKFFTFEQYKIAFTHSEIPLPVTMSF AGLFSGLTEAIVICPFEVVKVRLQADRNSSVKEQRSTASMAREIYRNEGFGTSGLYRG LGATLGRHGAWNMVYFGLYHSCREVIPDAK NPTSNLIGRIALGFTAGSLASIFNIPFDVAKSRIQGPQPDPFTRKYSGTMQTISLVYK EEGFGALYKGLLPKVMRLGPGGAVMLIVYDEVYSWLQKNT >Z46787 sequence 104 in alignment MPSPCESGKTTNCSGAPSSSCVTPLDVVKIRLQQQTRPFPKGEC FYYHNGLMEHVCVSCEVRKPCEWYQRPGNFRGTADAIVKIARHEGIRSLWSGLSPTMV MALPATVFYFTTYDNLSVWLKKKMCCRRAFSPEKWTPPDWSAAAVAGIVARTIAVTVV SPIEMIRTKMQSKRLTYHEIGHLVRSSMATKGISSFYLGWTPTMLRDIPFSGIYWAGY DLFKTNLQRRQGPDHNPFVVSFVSGAAAGVVASIFTHPFDVIKTNCQIRIGGSIDDMN KSITTVIKDMYHSRGISAFSSGLVPRLVKVSPSCAIMISFYEYFKFLFQKNH >Z66521 MRS3 like sequence 129 in alignment MGGGGEDEYESLPTHSVPVHLTAGALAGAVEHCVMFPFDSVKTR MQSLCPCPETKCPTPVHSLMSIVKREGWLRPLRGVNAVAAGSMPAHALYFTVYEKMKG YLTGNSAGHSNTLAYGASGVVATLIHDAIMNPAEVVKQRMQMAFSPYGSSLECARCVY NREGVAAFYRSYTTQLAMNVPFQAIHFMSYEFWQHVLNPEHKYDPKSHLIAGGLAGGL AAALTTPMDCVKTVLNTQQAAEADPANRRIFLQARYRYRGISDAVRTIYSQRGLSGFS CGLQARVIFQVPATALSWSVYELFKFMLSFEGGHSS >U80836 oxoglutarate carrier sequence 181 in alignment MSNEGGVPNVVKFAFGGTAGMGATLVVQPLDLVKNRMQLSGTTG KKEYRSSMHALTSIMKNEGVFAVYNGLSAGLLRQATYTTTRLGTYAFLLERFTEKDKP LSFGMKAVLGMTAGGIGSFVGTPAEIALIRMTGDGRLPVEQRRNYTGVVNALTRITKE EGVLTLWRGCTPTVLRAMVVNAAQLATYSQAKQALLASGKVQDGIFCHFLASMISGLA TTIASMPVDIAKTRIQSMKVIDGKPEYKNAFDVWGKVIKNEGIFALWKGFTPYYMRLG PHTVLTFIILEQMNAAYFQYVLKRDVTSALLCCVHFSDFKFWPEILF >Z71259 sequence 71B in alignment MDTAIEARSIATSPLNSKVSPLSQIQKDKLLVIQWEHLNLYKFY PMALCSSWTIRCMLYPMSVVKSRLQLQRQNNVYNGMRDAFVKIIRQEGIGALYKGFWM TLPQLSASFLYSSAYERVRDLLQTHLHITNHSVVSALAGGIASPCAQLIFVPTDIVAQ HMMVHNNPEAFGGFLSAIMLYIPSTMVFWSTYYNSLAVFRMIREKVTELEYGVKPTSP SEVDDRNLFLDQAVSGSIGGVASAMVTNPLEMLRIRLQQCNTAFVSPRRLLDAVQNCK FCVIISPQIPSFRSLRILFYELFFFFCNCFFNILFFLTILVRSLLIFEYKSFDVCFFF LIFPFEDAELLGDKVARYLAGKHKPIFHPETDCGDHVVVTNCKDIAMHAFDWKHTIYK FNMEYPKSKADIPAWQIHDYDQCRIAFLSVYRSLGNNLLRRRHIQRLHLFPDEEMAEF VRKNIGSQLRQVQGVVKRSDEYTAEERANFPRVVKFADKHVVDWEKSIPNPGRHVKPV PGQKDK Alphabetical list of accession numbers for 34 C. elegans carriers AC006765 U80836 oxoglutarate carrier AF003141 like ADP/ATP carrier AF003384 47% to human UCP4 brain protein AF043695 not similar AL008880 Z78542 AL009027 Z46787 AL009107 U49830 Z81586 similar to PO4 carrier AL022573 Z75532 38% to X76115 AL023633 Z66521 MRS3 homolog AL023841 Z70310 not similar to anything M89246 X76113, Z14659, Z68341, Z73103 PO4 carrier U00052 U23412 U23525 dicarboxylate carrier U49830 Z81586 AL009107 similar to PO4 carrier U58750 61% to Z78542 U61949 Z48240, X76115 DIF-1 U64842 ADP/ATP carrier U80836 AC006765 oxoglutarate carrier U80931 almost identical to Z68218 like ADP/ATP carrier 78% to AF004141 X76112 Z82059 Z92866 similar to ADP/ATP carrier X76113 Z14659, M89246, Z68341, Z73103 PO4 carrier X76114 dicarboxylate carrier X76115 U61949, Z48240 "c1" CEL04F8 DIF-1 X76116 Z49070 "c2" Z14659 X76113, M89246, Z68341, Z73103 PO4 carrier Z22180 Citrate carrier Z46787 AL009027 Z48240 U61949, X76115 DIF-1 Z49068 Z49070 X76116 "c2" Z49207 Z50873 79% to Z72511 Z66521 AL023633 MRS3 homolog Z68160 PET8 homolog Z68218 almost identical to U80931 similar to ADP/ATP carrier 76% to AF003141 Z68220 incomplete see align under citrate carrier Z68341 X76113, Z14659, M89246, Z73103 PO4 carrier Z68882 similar to ADP/ATP carrier Z70310 AL023841 not similar to anything Z71259 47% to AL023841 (partial) Z72511 79% to Z50873 Z73103 Z68341 X76113, Z14659, M89246 PO4 carrier Z74028 Z75532 AL022573 38% to X76115 Z75955 Z78542 AL008880 61% to U58750 Z79755 Z81577 contains a repeat element that should be removed Z81586 U49830 similar to PO4 carrier Z82059 X76112 Z92866 seq 35 on alignment Z92866 Z82059 X76112 seq 35 on alignment