Results from RNAi experiments on 86% of C. elegans genes. <p>
P450 Genes
CYP22 = the daf-9 gene important in development, probable sterol hydroxylase
CYP13A8 had 10% embryonic lethality, clear and sluggish
CYP13A4 and CYP42 are uncoordinated
CYP13A1 T10B9.8 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP13A2 T10B9.7 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP13A3 T10B9.5 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP13A4 T10B9.1 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes Unc (uncoordinated)
CYP13A5 T10B9.2 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP13A6 T10B9.3 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP13A7 T10B9.10 chr II
No RNAi experiment
CYP13A8 T10B9.4 chr II
Maternal Phenotype Normal
Embryonic Lethality Lethal : 10%
Other Phenotypes Clr (clear) Slu
(SLUggish)
CYP13A9P T10B9.6 chr II
No RNAi experiment
CYP13A10 ZK1320.4 chr II
No RNAi experiment
CYP13A11 F14F7.2 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP13A12 F14F7.3 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP13B1 F02C12.5 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP13B2 K06G5.2 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP14A1 K09A11.2 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP14A2 K09A11.3 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP14A3 K09A11.4 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP14A4 R04D3.1 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP14A5 F08F3.7
chr V (make correction to F09F3.7 in page)
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP22 T13C5.1 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
daf-9
mutant This gene may be in the pathway to synthesize a ligand for DAF-12
a
nuclear receptor. Daf-9 has a role
in larval development.
DAF
comes from abnormal DAuer Formation
CYP23 B0304.3 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP25A1 C36A4.1 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology; DIC phenotype -- Embryonic development normal)
DIC Phenotype refers to
Nomarski Differential
Interference Contrast (DIC) microscopy
CYP25A2 C36A4.2 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP25A3 C36A4.3 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP25A4 C36A4.6 chr III
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology; DIC phenotype -- Embryonic development normal)
Remarks This RNAi has
multiple targets in the genome, see also RNAi: TH:322H7_2 CYP25A5
DIC Phenotype refers to
Nomarski Differential
Interference Contrast (DIC) microscopy
CYP25A5 F42A6.4 chr IV
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology; DIC phenotype -- Embryonic development normal)
Remarks This RNAi has
multiple targets in the genome, see also RNAi: TH:322H7_1 CYP25A5
DIC Phenotype refers to
Nomarski Differential
Interference Contrast (DIC) microscopy
CYP25A6P K06B9.1 chr IV
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP29A1 C44C10.2 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP29A2 T19B10.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP29A3 Y38C9B.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
Small differences to CYP29A3
plus one extra exon (blue) probably an assembly error
MSLILPCLLI
ILLLFIVSFW KIMKNILKYR KYDDLLPGPP AHPIFGNTKT FSNKTTEEIF QALRDLFSEA VEKGQSLIRH
RILGTFYVWP
LDGKTVSCLT DFFSFPEVVV FWELAVLSIT
FLRCGFLQKP IIIDFLIFCS LNRYYNNSDD
FFKVFFFQKI
LESTTELDKG
GPYEFFNDWL GGGTLLEGYG ERWRSHRKML TPTFHFAKLE GYFEVFNTES RVVVDCLDKF AKSGETVDLF
PFFKRCTLDT
ICKTAMGAKV DAQLQNSHPY ITAIEQALQL GVLYAMNPHH QIPAIYWALG HQKKKDEYFN IMKTFTRNVI
AERRTARESG
EVEKETSKRN MNFLDILLSN EESSVLSPED LRQEVDTFMF AGHDTTTTSV SWVCWNLAHH PDIQQNVYEE
IVSVFGEDPN
EDVTTEGIKK LEYTERMLKE SKRICPTVPA VLRQLISDME IGGVLIPAGA NVAIAPMAIH KNANIYQNPD
IFDPDRFLPE
ETAKRHAYDF IPFSAGLRNC IGQKFAQLNE KVMVIHLLKN FKIEPMGGYY STKQVFEPVG KPSNGIPVRL
VRRL
CYP29A4 B0331.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP31A1P C01F6.3 chr IV
No RNAi experiment
Sequence given in Wormbase (below) is not the correct
gene assembly
MGVIILAVLL ASATVIAWLL YKHLRMRQAL
KHLNQPRSYP IIGHGLITKP DPEGFMNQVI GMGYLYPDPR MCLLWIGPFP
CLMLYSGDLV
EAIFSSTKHL NRILVQKLCC LGADERVDVL SVIALCTLDI ICETSMGIAI GAQLAENNEY VWAVHTINKL
ISKRTNNPLM
WNSFIYNLYG SFIINKENDY KMEGRLAFLD LLLEMVNSGQ MDETDVQAEG NTFMLEGHDT TSTGLMWAVH
LLGNHPDVQR
KVQAELDEVM GDDEDVTIEH LSRMKYLECA LKEALRLFPS VLIITRELSD DQVIGGFNIP KGVTFLLNLY
LVHRDPAQWK
DPDVFDPDRF HPENSIGRKS FAFIPFSAGS RNCIGQRFAL MEEKVIMAHL LRNFNIKAVE LMHEVRPKME
IIVRPVTPIH MKLTRRRPIA SP
CYP31A2 H02I12.8 chr IV
No RNAi experiment
CYP31A3 Y17G9B.3 chr IV
No RNAi experiment
CYP31A4P Note this
detritus exon is inside an intron of CYP31A3
CYP31A5P Y62E10A.15 chr IV
No RNAi experiment
A new CYP pseudogene not named before
MGVIIPAVLLASATVIAWLIYKHLRMRQVLKHLNQPRSYPIVGHGLITKPDPEGFMNQVI
60
GMGYLYPDPRMCLLWIGPFPCLMLYSADLVEPIFSSTKHLNKGFAYVLLEPWLGISILTS
120
QKEQWRPKRKLLTPTFHYDILKDFLPIFNEQSKILIQKLCCLGVADEEVDVLSVITLCTL
180
DIICETSMGKAIGAQLAENNEYVWAVHTINKLISKRTNNPLMWNSFIYNLTEDGRTHEKC
240
LHILHDFTKK
up to aa 250
gap
VRPKMEIIVRPVTPIHMKLTRRRPIVSP
C-term fragment
CYP32 C26F1.2 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33A1 C12D5.7
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33B1 C25E10.2 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C1 C45H4.2 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C2 C45H4.17 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C3 F41B5.4
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C4 F44C8.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C5 F41B5.3
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C6 F41B5.7
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C7 F41B5.2
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C8 R08F11.3
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C9 C50H11.15
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33C10P F41B5.5 N-term part chr V
No RNAi experiment
CYP33C11 Y49C4A.9 chr V
No RNAi experiment
CYP33C12P F41B5.5 middle part of gene chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
From 134-332 of CYP33C like
genes, not named before
Note: F41B5.5 is shown in
wormbase as including F41B5.6 inside it.
This seems unlikely, so I have
it as two different pseudogenes
ARLAEWKK
NFMGFFDSQI KHHKQKFDYD CEENQDSAEA YLKEQRRQED QGELELFSDK QLSNTCTDLW
IAGLSITNST LSWAICYLMN PPGVQEQIHA ELDNENIV
CYP33D1 K05D4.4 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33D3 Y17D7A.4 chr V some
small differences
No RNAi experiment
CYP33E1 C49C8.4 chr IV
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33E2 F42A9.5 chr IV
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP33E3P F42A9.4 chr IV
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
9483 MILALSLALLFLYLFHFIYWKRRNLPPG
9610 GPAPLPFVGNLLMLTEKVKPGYKLWDSLT
9743 QQYGSVFTFWMAGLPMVFVTDWKLIKQYFIKDGGSYVGRPEFPLNTEVK
9928 QIPEGPYGIIDAHGNRWIQQRRFALHVLRDFGLGKNIMEEKILTEVTVMIERLRKTIACV
DMQNVFDTSIGSIINSLIFGYRFDESEFGWKFEKSRRACSIFNWKTTVSRRRTCQNGIIS
VFCKLVQYIRYSTS 10330
CYP34A1 T10H4.10 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A2 T10H4.11 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A3 C41G6.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A4 T09H2.1
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A5 B0213.10
chr V
No RNAi experiment
CYP34A6 B0213.11
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A7 B0213.12
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A8 B0213.14
chr V
No RNAi experiment
CYP34A9 B0213.15
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP34A10 B0213.16
chr V
No RNAi experiment
CYP35A1 C03G6.14
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35A2 C03G6.15
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35A3 K09D9.2
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35A4 C49G7.8
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35A5 K07C6.5
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35B1 K07C6.4
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35B2 K07C6.3
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35B3 K07C6.2
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35C1 C06B3.3
chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35D1 F14H3.10 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP35D2P not annotated at Wormbase
Lies
between F14H3.7 and F14H3.8
14503
MILIALFFTIFTVITVRLYRKVLRFPPGPFPLPFIGNAHQIVYQAWSRGGTLPALDYYR 14561
14730 KNGNAYTLWLGPKAPVSLTDFETSQEVFVKQGKKCYNRQLAPILEHVTG
14762
14963 GVGLLTANGENWAEMRRFTLR
14933
CYP36A1 C34B7.3 chr I
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP37A1 F01D5.9 chr II
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)
CYP37B1 F28G4.1 chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP42 Y80D3A.5 Chr V
Maternal Phenotype Normal
Embryonic Lethality Normal
Other
Phenotypes Unc (uncoordinated)
CYP43 E03E2.1 chr X
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type
morphology)
CYP44 ZK177.5 chr II (only mitochondrial P450 in C. elegans)
Maternal Phenotype Normal
Embryonic Lethality Normal
Other Phenotypes WT (wild type morphology)