Comprehensive bacterial P450s Sept. 13, 2007
892 entries – 3 frags, - 11 variants, -
30 renamed seqs – 2 duplicates, - 1 deleted region in M. bovis
total of 853 unique sequences
18 are archaebacterial and 835 are bacterial
updated August 12, 2009, 923 sequences
D. Nelson
>CYP51B1 Mycobacterium tuberculosis (Actinobacteria)
Rv0764c
MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ
LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN
AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ
LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT
DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR
DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV
QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH
RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG
V
>CYP51B1 Mycobacterium marinum MM4932
MTTAIVPRVS
GGEEEHGHLE EFRTDPIGLM QRVRDECGDV GWFQLANKHV VLLSGAKANE
FFFRSSDEEL
DQAEAYPFMT PIFGKGVVFD ASPERRKEML HNSALRGEHM KGHATTIERE
VHRMIENWGQ
EGEIDLLEFF AELTIYTSTS CLIGTKFRNQ LDSRFAHFYH ELERGTDPLC
YVDPYLPIES
FRRRDEARKG LVALVQDIMH QRVANPPTDK RDRDMLDVLV SITDEQGNPR
FCADEVTGMF
ISLMFAGHHT SSGTSAWTLI ELLRHPDAYA AVIDELDELY ADGQPVSFHA
LRQIPRLENV
LKETLRLHPP LIILMRVAKG EFQVEGYPIH EGELVAASPA ISNRIAEDFP
DPDEFVPERY
QEPRQEDLIN RWTWIPFGAG RHRCVGAAFA TMQIKAIFSV LLREYEFEMA
QPADSYRNDH
SKMVVQLARP ARVRYRRRKM SDNRGH*
>CYP51B1 Mycobacterium ulcerans
MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANE
FFFRSSDEELDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIERE
VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGTDPLC
YVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSITDEQGNPR
FCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVIDELDELYADGQLVSFHA
LRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFP
DPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA
QPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH
>CYP51B1 Mycobacterium bovis subsp. bovis AF2122/97
(Actinobacteria)
NC_002945 complete genome complement(858662..858868)
CYP51
100% match
locus_tag = Mb0786c
>CYP51B1 Mycobacterium avium (Actinobacteria)
TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF
3021539
3021540
FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719
3021720
KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899
3021900
VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079
3022080
SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259
3022260
RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439
3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ
3022619
3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700
>CYP51B1 Mycobacterium smegmatis (Actinobacteria)
VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS
4858988
4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV
4859168
4859169
ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348
4859349
LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528
4859529
VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708
4859709
NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888
4859889
DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068
4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137
>CYP51B1 Methylococcus capsulatus (Proteobacteria)
908332 MSHPPSNTP
908305
PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126
908125
DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946
907945
LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766
907765
NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598
907597
EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418
907417
PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238
907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE
907061
907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980
>CYP51B1 Rhodococcus sp. RHA1 (Actinobacteria)
Rha05830
MNLATPQRVSGGEHEHGHLEELRTDPIALMRRVREECGNVGVFQLADKKVVLLSGAEANEFFFRSTDEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNQALRGEQMKGHAATIAHEVDRMVAQWGDEGEIDLLEFFAELTIYTSSACLIGKKFREQLDGRFAHLYHELEQGTDPIAYVDAYAPIESFRRRDEARVQLVALVQEIMNGRIENPPQGKEDRDMLDVLVSIKDEDGNERFTADEITGMFISMMFAGHHTTSGTAAWTLIELLRHPDYAKQVVAELDDLYSDGSDISFGALRQIPKLEAVLKETLRLHPPLIILLRVARGEFEVGGYRIAENDLVAATPAISNRIAEDFPNPDTFDPERYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLQDWEFEMAQPSETYRNDHSKMVVQLQQPCTVRYRKRST
>CYP51B1 Nocardia farcinica IFM 10152
(Actinobacteria)
MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE
LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN
SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE
LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA
DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP
ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV
CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH
RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR
TS
>CYP51B1 Mycobacterium vanbaalenii
MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSE
LNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEF
FAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVM
HGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFY
AKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASP
AISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM
AQPPESYQNDHSKMVVQLARPAKVRYRRRVRD
>CYP101A1 Pseudomonas putida
MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWA
VLQESNVPDLVWTRCNGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPT
SMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFP
IRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGT
DAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLSFSMEFLAKSPEHRQELI
ERPERIPAACEELLRRFSLVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENA
CPMHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQH
KSGIVSGVQALPLVWDPATTKAV
>CYP101B1 Novosphingobium aromaticivorans
MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF
HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG
LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA
EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE
TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL
RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD
PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN
SDLSPVPGIVGALRRVELVWNT
>CYP101C1 Novosphingobium aromaticivorans
MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA
NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM
KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR
PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP
WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR
RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR
HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL
VWRA
>CYP101D1 Novosphingobium aromaticivorans
MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW
KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP
TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF
PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA
RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP
ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG
LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK
DRAVPIYHSGIVAAVENIPLEWEPQRVSA
>CYP101D2 Novosphingobium aromaticivorans
MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM
YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI
FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA
RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG
NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV
NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL
KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT
LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR
>CYP101D3 Sphingomonas sp. SKA58
1 MPEHVPETMS RARAPRPEHI PEQYVHEIDM YALEGIEQGY
HEAWKNIPKP DMPDLIWTPF
61 TGGHWIATNG DTVREVYSDP TRFSSEVIFL PKEAGEKYEM VPTRMDPPEH
TPYRKALDKG
121 LSLAQIRKVE SKVRKVAVDL IDSFVSRGEC
DFSAEYANVF PVRVFMALAD LPESDVPTLS
181 RFAKMMTRPE GNTPEEMAKH LEEGNKGFFA
YVEPIIQARR GKEGEDLITV MVNAEINGER
241 ITHDKALGLI SLLLLGGLDT VVNFLSFMMI
HLAKNPQVVE ELRADPLKLM RSAEEMFRRF
301 PVVSEARMVA KDQDFRGIEL KRGDMILLPT
ALHGLDDQLN DDPWRINLER RGISHSTFGG
361 GPHRCAGLHL ARMEVIVTIE EWLKRIPTFA
MKPGAQPIYH SGIVAAVDNV PLIWSER
>CYP102A1 Bacillus megaterium
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFE
APGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHN
ILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFN
YRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVD
KIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSF
ALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL
YAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFK
PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAK
SKKIPLGGIP
>CYP102A2 Bacillus subtilis
MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI
HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH
NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF
NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV
DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL
SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF
SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA
YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS
VQSRHQEAIHADVQAAEKAAPDEQKEKTE
>CYP102A3 Bacillus subtilis
MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF
DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH
RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF
NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV
DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL
SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF
SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA
YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT
VKPRKTAAINV
>CYP102A4 Bacillus anthracis str. Ames
1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG
PIFRMQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR
ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE
NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK
LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP
IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF
ALHEATLVMG
421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE
EKLKNHEIKQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVAAL
NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKG DELKGVQYAV FGCGDHNWAS
TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQRMWSDAMK VFGLELNKNM
EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK
EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE
VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF
EPFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK
DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNVGEAHLYF
GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGQAKTY VQHVIKEDRI HLISLLDNGA
HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR
LQEEGRYGKD VWAGI
>CYP102A5 Bacillus cereus ATCC 14579
1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG
PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR
ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG
DQEENDLLSR
241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP
IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF
ALHEATLVMG
421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE
DKLKNDEIKQ
481 HVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL
NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS
TYQRIPRYID
601 EQMAQKGATR FSKRGEADAS GDFEEQLEQW KQNMWSDAMK AFGLELNKNM
EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSDRSTRHIE VSLPEGATYK
EGDHLGVLPV
721 NSEKNINRIL KRFGLNGKDQ VILSASGRSI NHIPLDSPVS LLALLSYSVE
VQEAATRAQI
781 REMVTFTACP PHKKELEALL EEGVYHEQIL KKRISMLDLL EKYEACEIRF
ERFLELLPAL
841 KPRYYSISSS PLVAHNRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK
DEIICFIRTP
901 QSNFELPKDP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNLGQAHLYF
GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHLIKQDRI NLISLLDNGA
HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR
VQDEGRYGKD VWAGI
>CYP102A6 Bradyrhizobium japonicum USDA 110
1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE
LGPIFWLDMM GSPIVVVSGH
61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF
YRRDYHPFVE
181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS
AEGIDDKKDM
241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH
PDILKKAYDE
301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET
IGGGKYKLRK
361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ
RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG
AYGGPVAAVS
481 SAPRAPRQPT ARPGHNTPML VLYGSNLGTA EELATRMADL AEINGFAVHL
GALDEYVGKL
541 PQEGGVLIIC ASYNGAPPDN ATQFVKWLGS DLPKDAFANV RYAVFGCGNS
DWAATYQSVP
601 RFIDEQLSGH GARAVYPRGE GDARSDLDGQ FQKWFPAAAQ VATKEFGIDW
NFTRTAEDDP
661 LYAIEPVAVT AVNTIVAQGG AVAMKVLVND ELQNKSGSNP SERSTRHIEV
QLPSNITYRV
721 GDHLSVVPRN DPTLVDSVAR RFGFLPADQI RLQVAEGRRA QLPVGEAVSV
GRLLSEFVEL
781 QQVATRKQIQ IMAEHTRCPV TKPKLLAFVG EEAEPAERYR TEILAMRKSV
YDLLLEYPAC
841 ELPFHVYLEM LSLLAPRYYS ISSSPSVDPA RCSITVGVVE GPAASGRGVY
KGICSNYLAN
901 RRASDAIYAT VRETKAGFRL PDDSSVPIIM IGPGTGLAPF RGFLQERAAR
KAKGASLGPA
961 MLFFGCRHPD QDFLYADELK ALAASGVTEL FTAFSRADGP KTYVQHVLAA
QKDKVWPLIE
1021 QGAIIYVCGD GGQMEPDVKA ALVAIRHEKS
GSDTATAARW IEEMGATNRY VLDVWAGG
>CYP102A7 Bacillus licheniformis ATCC
14580
1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP
IFQFKFADAI GVFVSSHELV
61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM
121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE
GQHPFIESMV
181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES
ESGNDLLSLM
241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL
KKAYEEADRV
301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI
PKGQSVTVLI
361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL
HEATLVLGMI
421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN
GRQEERPSAP
481 AAENTHGTPL LVLYGSNLGT AEEIAKELAE EAREQGFHSR TAELDQYAGA
IPAEGAVIIV
541 TASYNGNPPD CAKEFVNWLE HDQTDDLRGV KYAVFGCGNR SWASTYQRIP
RLIDSVLEKK
601 GAQRLHKLGE GDAGDDFEGQ FESWKYDLWP LLRTEFSLAE PEPNQTETDR
QALSVEFVNA
661 PAASPLAKAY QVFTAKISAN RELQCEKSGR STRHIEISLP EGAAYQEGDH
LGVLPQNSEV
721 LIGRVFQRFG LNGNEQILIS GRNQASHLPL ERPVHVKDLF QHCVELQEPA
TRAQIRELAA
781 HTVCPPHQRE LEDLLKDDVY KDQVLNKRLT MLDLLEQYPA CELPFARFLA
LLPPLKPRYY
841 SISSSPQLNP RQTSITVSVV SGPALSGRGH YKGVASNYLA GLEPGDAISC
FIREPQSGFR
901 LPEDPETPVI MVGPGTGIAP YRGFLQARRI QRDAGVKLGE AHLYFGCRRP
NEDFLYRDEL
961 EQAEKDGIVH LHTAFSRLEG RPKTYVQDLL REDAALLIHL LNEGGRLYVC
GDGSRMAPAV
1021 EQALCEAYRI VQGASREESQ SWLSALLEEG
RYAKDVWDGG VSQHNVKADC IART
>CYP102A8 Bacillus thuringiensis serovar konkukian str. 97-27
1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG
PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETDEPNWK KAHNILMPTF
SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR
LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH
DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH
ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP
TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDDVEEFQ PERFEELDKV
PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEDYQLDVKQ TLTLKPGDFK
IRIVPRNQTI SHTTVLAPTE EKLKKHEIKK
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI
ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP
DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK
AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS
SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NNEKNVNRIL KRFGLNGKDQ VILSASGRSV
NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL
KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW
SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL
QARRVQKQKG MKVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY
VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR
LQEEGRYGKD VWAGI
>CYP102A9 Bacillus weihenstephanensis KBAB4
1 MDKKVSAIPQ PKTYGLLGNL PLIDKDKPTL SFIKIAEEYG
PIFRIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF
SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR
LTLDTIGLCG FNYRFNSYYR ETPHPFITSM
181 SRALDEAMHQ LQRLDIEDKL MWRTKRQFQH
DIQSMFSLVD NIIAERKSSG NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH
ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYIRM ILNESLRLWP
TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKI
PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YQDYQLDVKQ TLTLKPGDFK
IRILPRNQTI SHTTVLAPIE EKLKNDEIEQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI
ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKS
DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW
KQSMWSDAMK AFGLELNKNI EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS
SSERSTRHIE ISLPEGATYQ EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV
NHIPLDSPVS LFDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELELLL EEGVYHEQIL
KKRMSMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW
SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGVAPFRGFL
QARRVQKQKG INLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHIAF SRLEGYPKTY
VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR
VQEEGRYGKD VWAGI
>CYP102A10 Erythrobacter litoralis HTCC2594
1 MDAPTALAPI PQPPGKPIVG NAFTVDSSRL IQSLMELAEE
YGPIFQLEVM GTPLVFVSGA
61 DMVAEICDES RFDKTVRGPL KRLRLIAGDG LFTGDTDDPN WAKAHHILLP
SFSQKAMGSY
121 LPMMTDIASQ LMLKWERLNS DDVIDVPMDM
VRLTLDTIGV CGFGYRFNSF YREDFHPFIE
181 ALNRTLDTTQ KMRGLPGEKL LKRQQIEQLN
EDAAYMNNLV DEIIRERRQT GESGQGDLLD
241 FMLSGRDPVT GERLSDENIR YQINTFLIAG
HETTSGLLSF TLYYLLKNRD VLQRAYAEVD
301 EVLGRNIDQT PTLSQIGRLP YIRAILSEAL
RLWPTAPAMG LAPFEDEVLG GKYAIAKGTF
361 TTVLIPSLHR DKLVWGENPE AFNPDNFSPK AEAARPPHAY
KPFGNGQRAC IGRQFAIQES
421 ILVLGMLLQR FELFDHADYQ LRIKETLSIK
PDGFTIKARL RHDVERGGVA TVEPESKTPD
481 QAAAVPSHGT PLLVLYGSNL GSSEGFAREL
AQRGEFSGFD VTMAPLDAHV AKLPTDGAVA
541 IACASYNGMP PDNAAKFVDW LEQADAADAP
LSNVSYLVLG CGNSDWAATF QVVPRKIDAL
601 MEQHGAERLV PAEELDARGD LDTQFHDWLD
GLIPQLGDAF DIDLESGFDA VFEPLYTVEI
661 TDSITGNTVA DRVGAREVEV VANRELKDTS
KDEGRSTRHL EVRLPEGMEY EPGDHLCVVP
721 VNDPAVVDRL LKRFGLDRDT FVRIESRSDM
RGPFPSGSTF SVLNLAETAG ELQAVATRKD
781 IATLARYSEC PNSRAALEAL AAPPSADGTD
RYTSEVLEKR RSVLDMLEEF PACDVPLAVF
841 LELIPFLSPR YYSISSAPEA NQGLCSITVG
VVKGPALAGT GEFKGTCSAY LADLPPGDRF
901 RAVVRKPTAQ FRLPDNPETP VIMIGPGTGV
APFRAFLQRR DHLQEDGAVL GEAMLFFGCR
961 HPDIDYLYRE ELDDYDQRGV ATVHAAFSRH
DGSRTYVQDL IAREADRVWE LIEQDARIYV
1021 CGDGARMEPD VRKALMAIYA EKKSSDEASA KAWIDDLVAQ
DRYLLDVWVG
>CYP102A11 Erythrobacter sp. NAP1
1 MATNATLTPI PQPPGKPLIG NALTVDASQQ IQSLMELAEE
YGPIFQLDMM GTPIVIISGA
61 DLVAEVCDEK RFDKSVRGPL KRLRLIGGDG LFTGDTDAPN WSKAHNILLP
SFSQKAMGSY
121 LPMMTDIATQ LVMKWERMNS DDVIDVPKDM
IRLTLDTIGV CGFGYRFNSF YREDFHPFIR
181 ALTRTLETTQ KIRGIPGEKL LKGDAVKQLH
RDAKYMNNLV DEIIRERQRS GGDGPEDLLD
241 FMLSGRDPLT GERLSDENIR YQINTFLIAG
HETTSGLLSF TLYYLLKNRD VLTRAYAEVD
301 TVLGRNIDQP PSLKQIGQLP YIRAILFEAL
RLWPTAPAFG LAPFEDEVLG GKYLIPKGTF
361 TTVLIPSLHR DKSVWGENPE VFDPENFTAE
AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLAMILQR FELFDHSDYK LDIKETLSIK
PDEFTIKARM RKDVERGGKA TEDAEEASTE
481 PAEPKVPKHD TPLLVLYGSN LGSSESFARE
VAQKGEFSGF EVEMAPLDDY VGKLPEDGAV
541 AIACASYNGM PPDNAAKFID WIEGKDGAAP
DLSGVSYMML GCGNSDWAAT FQAVPRLIDA
601 RMEELGAKRI VPTTELDARS DVDTQFHTWL
DALMPQLGEH FDLDLSGEAA GIAEPLYKVE
661 VTQSVTANTV ASRVGAHAVK MVANRELKNT
DIGEGRSTRH IEVELAQGET YQPGDHLCVV
721 PENDDAVVER LLRRFNLDAD TYVRIESRSE
MRGPFPSGST FSVYNLAKTA GELQAVATRK
781 DIATLALYTE CPNSKPALEK LAQPPQEDGT
DQYATDVLAK RKSVLDLLED YPACDLPLAV
841 FLEMIPFLSP RYYSISSAPG DTPQTCSITV
GVVKGPALSG KGTFKGTCSN YLAELEPGAS
901 FNAVVREPTA NFRLPDDPKV PLIMVGPGTG
LAPFRGFLQE RDALASSGEE LGPARLYFGC
961 RTPDEDFLYR DELEDYDKRG IVTLRTAFSR
VDEGKCYVQD HIADDADAIW EMLEAGGRIY
1021 VCGDGARMEP DVRAALAKIH SDKTGSTPAE
AQSWVGDLIT NERYSLDVWV G
>CYP102A12 Rhodopseudomonas palustris HaA2
1 MSSSNKLAPI PHPPKQPVVG NMLSIDTKAP VQHLVRLAEE
LGPIFWLDMM GAPIVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRVRTVGGDG LFTADTSEPN WSKAHNILLT
PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL
CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRDTLA
EDVAFMNAMV DEIIAERRKA AAVADKMDML
241 GAMMTGVDKV TGEPLDDVNI RYQINTFLIA
GHETTSGLLS CAIYALLKHP EVLQKAYDEV
301 DRVLGADTSV EPSYQQVNQL GYITQILKET
LRLWPPAPAY GVAPIQDETI GGQYHLKRGT
361 FTTVLVLALH RDPSIWGPNP DAFDPENFSR
EAESKRPANA WKPFGNGQRA CIGRGFAMHE
421 AALALGMILQ RFKLIDHTRY RMVLKETLTI
KPEGFKIKVR PRSDKDRATR IASGVSHSVA
481 PAPAAPRARP GHNTPLLVLY GSNLGTAEEL
AHRVADLADL NGFATRLGAL DQYVGQLPEE
541 GGVLIFAASY NGAPPDNATQ FVRWLSGDLP
PDAFAKLRYA VFGCGNRDWT ATYQAIPRLI
601 DERLAAHGGR NIFVRGEGDA RDDLEGQFEA
WFATLGPLAV KEFGIDAAFD RGADDTPLYG
661 IEPLAPAASQ PLAATGVAVA MRVLENRELQ
DRAASGRSTR HIEIALPQGM SYRVGDHLSV
721 IPRNDPALVA AVAQRFGFAP DDQIRLSAAP
GRRAQLPVGE AVSIGGLLGD HVELQQVATR
781 KQIVALAAHT RCPQTRPKLQ ALAGGDGAAD DAYRAEVLGK
RRSVFDLLQE HPACELPFAA
841 YLEMLTPLQP RYYSISSSPA RDPARASVTV
AVVEGPALSG RGIYRGACSS WLAGRGSGDT
901 VQATVRATKA CFRLPDDDRV PLIMIGPGTG
VAPFRGFLQE RSARKVGGAT LGPALLFFGC
961 RHPAQDYLYA DELQGFAADG IVELHAAFSR
GDGPKTYVQH LIAAQKDRVF ALIEQGAIVY
1021 VCGDGGRMEP DVKAALCAIH RERSGADATA
AAAWIADLGA RDRYVLDVWA SV
>CYP102A12 Rhodopseudomonas palustris HaA2
1 MPSTNKLDPI PHPPKKPVVG NMLSLDTTAP VQHLVRLAKE
LGPIFWLDMM GAPLVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRARAVGGDG LFTADTKEPN WSKAHNILLT
PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM
TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRETLA
DDVVFMNAMV DEIIAERRKA SESAADKKDM
241 LGAMLAGVDR ATGEPLDDVN IRYQINTFLI
AGHETTSGLL SCAIYALLKH PDVLQKAYDE
301 VDRVLGSDTA VRPSYQQVNQ LSYITQILKE
TLRMWPPAPA YGVAPIKDEV IGGKYHLKRG
361 TFVTVLVLAL HRDPAIWGPN PDAFDPENFS
REAESKRPAN AWKPFGNGQR ACIGRGFAMH
421 EAALALGMIL QRFQLIDHQR YRMVLKETLT
IKPEGFKIKV RPRSDKDRGD FVAAGASQVS
481 TPALAQAAPR ARPDHNTPLL VLYGSNLGTA
EELATRVADL AELNGFSTRL GALDQYVGHL
541 PEEGGVLIFT ASYNGAPPDN ATQFVQWLSG
DLPKDAFAKL RYAVFGCGNR DWTATYQAIP
601 RLVDERLAAH GGRNIFLRGE GDARDDLEGQ
FESWFAKLGP LAVKEFGIDA KFARAVDDAP
661 LYRIEPVAPA AGNAVAAAGG AVPMKVLANR
ELQDCAASGR STRHIEIALP EGISYRVGDH
721 LSVMPRNDPA LVAAVAQRLG FAPDDQIKLQ
VAPGRRAQLP IGEAISVGRL LGDFVELQQV
781 ATRKQIAVMA EHTRCPQTRP KLQALAGGDG
AADEAYRAGV LAKRKSVYDL MQEHPACELP
841 LHAYLEMLSP LAPRYYSISS SPLRDPSRAA
ITVAVVDGPA LSGRGHYRGV CSTWLAGRSV
901 GDTIHATVRA TKAGFRLPDD DRVPLIMIGP
GTGLAPFRGF LQERAARQQN GATLGPALLF
961 FGCRHPAQDY LYADELQGFA AEGVVELHTA
FSRGEGPKTY VQHLIAAQKD RVFTLIEQGA
1021 IIYVCGDGGK MEPDVRAALM AIHRERSGAD
AAAASTWIDD LGACNRYVLD VWASA
>CYP102A13 uncultured soil bacterium
1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE
LGPIFWLDMM GAPIVIVSGY
61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ
PFGNRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM
TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA
TDVAFMNKMV DEIVAERRKS AEASDGKKDM
241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI
AGHETTSGLL SYAIYALLKH PDVLKKAYAE
301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE
ALRLWPPAPA YGIAPLKDET IAGGKYSLKK
361 NTFISILVTA LHHDPAVWGP NPDLFDPENF
SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL
TIKPDGFKIK VRPRSGHDRT VHAEAATAAV
481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA
EDLATRVADL AEVNGFATRL APLDDCAGQL
541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG
ELPNDAFAKL RYAVFGCGNR DWAATYQSVP
601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ
FESWFAALGA AAVKEFGLES RFSRSADDAP
661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR
ELQNKSGPDA SERSTRHIEV QLPGGMTYRV
721 GDHLSVVPCN APALVDRVAR RFGFLPADQI
RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL
781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG
DDADSSERYR ADILSRRKSV YDLLEEFPAI
841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS
RCSITVGVVS CPASSTGRGL YRGVCPYYLA
901 SRREGESVFA TVRETKAGFR LPDDPSVPII
MIGPGTGLAP FRGFLQERAA RKAGGATLGP
961 AMLFFGCRHP EQDYLYADEL KAFADEGITE
LFVAFSRSEG PKTYVQHLLA TQKARVWDLI
1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC
TGADANGGAK WIADLGAQNR YVLDVWAGG
>CYP102B1 Streptomyces coelicolor cosmid F43.
MAQTAREPARDGLPKGFRSAELGWPELHRIPHPPYRLPLLGDVV
GASRRTPMQDSLRYARRLGPIFRRRAFGKEFVFVWGAALAADLADEARFAKHVGLGVA
NLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFSREAMAGYHVMMLDVAARLTGHWDLAE
ASGRAVDVPGDMTKLTLETIARTGFGHDFGSFERSRLHPFVTAMVGTLGYAQRLNTVP
APLAPWLLRDASRRNAADIAHLNRTVDDLVRERRANGGTGGGTGSGSGSGDLLDRMLE
TAHPRTGERLSPQNVRRQVITFLVAGHETTSGALSFALHYLAQHPDVAARARAEVDRV
WGDTEAPGYEQVAKLRYVRRVLDESLRLWPTAPGFAREAREDTVLGGTHPMRRGAWAL
VLTGMLHRDPEVWGADAERFDPDRFDAKAVRSRAPHTFKPFGTGARACIGRQFALHEA
TLVLGLLLRRYELRPEPGYRLRVTERLTLMPEGLRLHLVRRTAAAPAPGRRTAAPGAA
DDAGDTVSAPGCPVHRAGD
>CYP102B2 Streptomyces avermitilis
MAQSTRTVIPKGFRSAELGWPELHRIPHPPHRLPVVGDVLGVNV
RTPVQDSLRIGRRLGPVFRRKAFGKEIVFVGGADLAAELADESRFAKHVGLGVANLRP
VAGDGLFTAYNHEPNWQLGHDVLAPGFSREAMAGYHPMMLAVTERLIDHWDREQTAGR
AVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVTAMVGTLTYAQRRNVVPEPLA
PLLLRTATRRNAADLAYLNRTVDALVRARRTTSGEGDLLDRMLDTARPGTGERLAPEN
IRRQVITFLVAGHETTSGALSFALHYLSRHPDVAARARAEVDRVWGGTARPGYDQVAK
LRYVRRVLDESLRLWPTAPAFAREARRDTVLGGVHPMREGAWALVLTAMLHRDPGVWG
ADAERFDPDRFDAQAVRSRAAHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYELR
AEPGYRLRVAERLTLMPEGLRLRLDRRVPAVEDVPVANPEVSSGPRCPVTGAGE
>CYP102B3 Rhodococcus sp. RHA1 Rha05872
MPVTVLLDTGSVRGTLRTRHQFSNAGHIDTGVDMSVESLHTTADATIPHPRWRLPVVGDVFGISIRTPLQNSMEIGRKLGPIFERNVLGNRFVFASGADMVAELSDESRFAKHLAPGVASLREVGGDGLFTAYNHEPNWSKAHNLLAPAFTKSAMRSYHRTMLDVAGELTEHWDERVDGSPVDVSSDMTKLTLETIGRTGFSYSFDSFGRERPHPFVQAMVGALSHSQRTTFVKSSALGRLLMRRSDRRNIANLEHMAEVVDEVIRARRDSAEDGPEDLLELMLRAARENDPHRIDELNIRHQVVTFLVAGHETTSGALSFALYYLSRHPDVLAKAQAEVDAVWGDEEPAFEQIAKLRYVRRVLDESLRLWPTAPAYGREATVDTTLVGKYPMKVGDWVLVLIPALHRDPVWGDDPEAFDPDHFLPERIRSRPAHVYKPFGTGERACIGRQFALHESVLVLGTILRRYDIVGDPDYRLKVAERLTLMPEGFTLQLRRR
>CYP102B4 Streptomyces scabies SCAB9321
MTATTAATAI SGFRSAELGW PELHRIPHPP FRIPLLGDVL
GTNVRTPVQE STRLGQRLGP
IFRRKAFGKE IVFVGGAELA AEMADEARFA KHVGVGVANL
RPVAGDGLFT AYNHEPNWQL
AHDVLAPGFG REAMAGYHPM MLDVAERLIE HWDREETAGS
AVDVPGDMTK LTLETIARTG
FGHDFGSFER TRPHPFVAAM VGTLTYAQQR NVVPDPLVPV
LLRGAAQQNR ADMAFLVETV
DAVVRARRSP GGGRGAGDGD LLDRMLETAH PETGERLSAE
NVRRQVITFL VAGHETTSGA
LSFALHYLAR YPDLAARARA EVDRVWGDAA RPGYEQVAKL
RYVRRVLDEA LRLWPTAPAF
SREAREDTVL GGVHPMRRGA WALVLTSMLH RDPEVWGADA
ERFDPDRFDA AAVRGRAPHT
FKPFGTGARA CIGRQFALHE ATLVLGLLLR RYELTPEPGY
RLRVVERLTL MPDGLRLRVR
RRAGAGTDAP RTPSSPPTPS SAPSGRPVTG AGE
>CYP102C1 Rhodococcus sp. X309
AAAGGKIDATADANKLALDVIGLAGFGYDFASFDGDEHPFVGAM
SRVLEHVNRTSNDIPFLRKLRGNGADLQYEKDIAFVRTVVDDVITERQAKPGEHQDDL
LDLMLNNIDDETGEKLDPVNIRNQVLTFLVAGNETTAGAIAFALYFLSRHPEIADAAR
AEVADITGGETPAFEDVARMRYLRRVVDETLRLWPSAPGYFRKVRTDTTLGGRYAMPK
GSWVFVLLPQLHRDPVWGENPDSFDPDRFKPENVKKRPAHAYRPFGTGPRSCIGRQFA
LHEAVLSLATILQRYSFQSDPEYKLDVREALTLKPVGLELSLQRL
>CYP102C2 Rhodococcus erythropolis PR4
1 MNGPRGSRTR PRRASLVNLA VLGVVLVHTV LMSADKCPYP
KSATRAGEIT AVQPQVFESI
61 PSPAWRLPLL GDLLTVDSEK PIQKEMALAS KLGPIFEWKI VNNRVTVVSG
VDLVAEVNNE
121 ALWAKSVGLP ILKLRKVAED GLFTAFNSEP
NWRKAHNILS EGFSRSALRN YHPSMLRALG
181 GLTDSWDRVA DAGETIDASS DANKLALDVI
GLAGFGYDFA SFIGEEHPFV GAMSRVLAHV
241 NSTSNDIPFL RKLRGNGADL QNEKDIALLR
TVVDNVIAER QSKPGEHQDD LLDLMLHSAD
301 AETGEKLDPV NIRNQVFTFL VAGNETTAGT
LAFALYFLSR HPDVADTARA EVADVTAGET
361 PAFEDVARMR YLRRVVDETL RLWPSAPGYF
RKVRTDTTLG GRYDMPKGSW VFVLLPQLHR
421 DPVWGEDPES FDPDRFKPEN VKKRPAHAYR
PFGTGPRACI GRQFALHEAV LALAIILQRY
481 NFQSDPEYKL DIRETLSLKP VGFELSLQRR
>CYP102D1 Streptomyces avermitilis
MTTQPETDLRPIRSPRGVPLFGHTPQIPSTNPVEYFGKLSKQFP
EGLYGMEIAGIEQVFVWDPDLVAEVCDETRFFKQIDKTPLAHVRDYAGAGLFTAHQHE
EEWGMAHRVLLPVFSQRAMKGYFGQMLEIAQNLVGKWERKEGQPVNITDDYTRLTLDT
IALSGFGYRFDSFAKEDLHPFLNALLQALVESLRRSQELPVMTKMRKADDKKYRENIR
LMRDLVENVIKERREGKGTGEDDLLGLMLEATDPETGKGLDDDNVRDQVVTFLIAGHE
TTSGLLSFATYSLMRNPHILAQAYAEVDRLLPGDTVPDYDTIMQMDVIPRILEETLRL
WAPIPMIGKSPLEDTVIGGCYGLKKGARVNILEGPLHTHPKAWERPEEFDINRWLPEN
RVNHHPHAYKPFGNGVRACIGRQFALTEARLALALVLQKFKFADTDDYKMDVKEALTR
KPGGFELNVRARQEHERTVFGAAD
>CYP102E1 Ralstonia metallidurans
MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS
SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM
KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP
FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD
LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY
AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD
RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE
AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV
TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA
VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY
QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV
QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY
RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI
ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA
>CYP102F1 Actinosynnema pretiosum subsp. auranticum
MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG
IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW
GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA
LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM
NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET
TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP
TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE
IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP
DSLVVRARPRADRPGATATVETVVPHQVPATHRHGTPLHVFYGSNGGSGEGLARTIAG
DGAARGWATSVAPLDDAVRALPASGPVVIVSSSYNGAPPDNAAHFVRWLTQDGPDLSG
VDYLVLGCGNLDWSATYQRVPTLIDEAMAAAGARRLRERGATDARADFFGDWERWYEP
LWPLLSAECGVEVGEIGPRFRVVESDAADGLGDLASAVVLENRELVRGPDAGSKRHLE
LRLPDGTSYRTGDYLSVLPQNHPDLVRRAVARLGTRAERVVTVESSAPTGLVPVGRAL
RVDELLTRCVDLSAPAGAGVVARLAERCPCPPERAELAATTGATLLELLERFPSCAVD
LALALELLPAPRTRLYSISSAAEEQRAEVALTVSVTGVTSGYLSRVRPGDRVAVGIAS
PPESFRPPADNTVPVVLIAAGTGIAPFRGFLRARAALGGEPGPALLLFGCRGPELDDL
YAEEFAALGDWLEVDRAYSRHPDGEVRHVQHRLWQRRDRVRELVDAGARVYLCGDATR
VGPAVEEVLGRIGPGAGWLDALRAGGRYATDVF
>CYP102G1 Streptomyces scabies SCAB5931
MTHATERGTE SIPERSALPL VGHAFDIPGG ADGLLHLMKE
ARELGPLFKL RVFGNEINIA
SGLDLVTELS DESRFRKNVH ADLVLVREIT GDGLFTAFND
EPNWRKAHDV LMPAFSLGAM
RGYHATMLKV ARELIGKWDG AAGTEPVDVA EDMTRLTFDT
IGLCGFGHDF ESFGRPEPHP
FVTALSRALG FAQAKGESIP GLDLFKWKQA EQFRTDVAVM
RDLVDDVIRE RRASGDTGTD
DLLGRMLHTR DQVTGEPLDD VNIRHQAITF LIAGHETTSG
ALSFALYYLT KHPEVLARAQ
AEVDALWGDT DTPDPDYGDI GKLTYIRQVL NEGLRLWPTA
PAYAVEPLED TVIGGRYAVR
EGETIQVLIP QLHRDPAWGE NVELFDPDRF LPEREQERPV
HLFKPFGSGE RACIGRQFAL
HEATLVLALV IHRYRLIDHT DYQLKIKQSL TIKPDEFTLR
LARRTAGERR LPLVASDRAP
AGEAPPAVRR AAGTTLTLLH GSNLGTCAGI ARELAEDGEQ
HGFAPTVASL DSAAGTLSAV
DGPVVIVAAS YNGRPTDDAT RFMEWLDDLA PGSLDGLRYA
VLGVGDRNWA ATYQRVPALI
DERLSAAGAT ALLERGAADA SGDFAGTVDR WTGELWTTLL
DRHGTAQDGV AAQPDTDAEG
GLYVLEDTTD SVIGGLAARH GVQPMEVLDA RELVDMSHGL
GRSKRFLRLR LPEGVTYRTG
DHLAVLPRNP DHLVRRVTDR FGLDPDRTVR LRARRRGRNT
LPVDRPLTVR RLLTDFVELQ
DPATREQIAV LAEHTACPPE KRPLTELAAA DPETFREQVT
AAGRSVLDLL ERHRACELPF
ERFLELLPVL RPRPYSISSS ALAAPGEVDL MVSLLAAPHR
AGEGMFHGIG SHFLQTVRPG
DTLQARVLPC SEAFRLPDDT SASVILVSAG TGLAPFRGAV
LDRRHAGSTG TLLCYFGCDH
PDVDYLHRAE FEAAEAAGAV SMRPAFSCAP EDGVRFVQDR
IGKESDEVWA ALEAGARVHV
CGDGRRMAPA VREAFRALYR ENTGADDAEA TAWLDALTES
GHYVEDVWAG
>CYP102G2 Saccharopolyspora erythraea NRRL23338
MTQTPLHHDDVPVADVSGTGLTATPTQQAMELARRHGPVFRRRTREFQSLLVSDVDLVAE
LSDEQRFAKAVGPALENVREFAADGLFTAYNDEFNWAKAHDILMPAFALGSMRTYHPVML
RVARRLLDSWDRAAAASAPVDVPDDMTRMTLDTIGLAGFGFDFGSFGRAEPHPFVGAMVR
CLDWSMTRLSRVPGTDHSERDEAFRADARYLASVVDEVINTRAAEGDTSGEDLLGLMLGA
RHPADGTTLDAANIRNQIITFLIAGHETTSGTLSFALHYLAKNPTVLRLVQREADELWGD
SPDPEPSFEDIGRLTYTRQVLNETLRLWPSAPAFGRQARHDTVLGGRIPMRAGEAAAVLI
PMLHRSPVRGDNPELFDPARFAPEAEAARGPHAFKPFGTGERACIGRQFALDEATMVLAM
LAHRYRLVDHAGYRLKVKETLTLKPEGLTLAVRARTAADRVTNRLALPVGLPSAAPGEPA
DAARRPGRVLPGTGLLLLHGSNYGTCRDFAAQLALAAGELGCDTAVAPLDEYAGNLPSDR
PVIVVAASYNGRPTDDAVSFSRWLDEAEPGAADGVDFAVLGVGDRNWAATYQHVPTRIDA
RLAELGGTRILERGEADASGDLAGAVRRFSAALETALLERSGDPDAVAAAPEGDGPAYTV
SEVTGGALDSLAARHGMVEMTVTEVADLTAPDYPRTKRFVRLALPEGTAYRTADHLAVLP
VHDAALVERAAGVLGVDLDTVLDIRAKRPGRLTFDRSLTVRELLSHHVELQDPPTPDGLD
ALAALNPCPPERAALRGLAEEARSGTADHRTLWDLIEDHPALRDALSWSALLELLPATRP
RQYSVSSSPAVDPRHVDLMVSVLRAPARSGRGEFRGAGSRHLSEVRPGDTVLARVQPCRE
DFRVAPDEPLIMVAAGTGLAPFRGVIADRRERVANGARQAPALCYFGCDAPDADYLHSAE
LRAAESAGAVAMRPAFNEAPVGGQCFVQHRIAAEAGEVWALLESGARVLVCGDGRHMAPG
VREAFRGIYRERTPGADDASAHEWLQAMIAGGCYVEDVYAG
>CYP102H1 Nocardia farcinica IFM 10152
plasmid pNF1
MAVTTSTTSGGHSNPPLPHPKWRLPIINDLLTINPIKPTLTSLR
DAEQLGGIFERRLVDWPMIVVSDSELITEICDERNWAKHLGVPLRKMRHIARDGLFTA
RNDEPNWAKAHAVLAPAFTKEAMRSYHQTMLTTIGELLDYWAKRDGQWVDVGEDMNKL
TLEIIARTGFDYTFDSFTRSEVHPFVAAMLRGLTYISRNSNMPPFLQKTIGARAAARH
SRDITYVRTVVDDVIKARQASGTVGDHHDLLDRMLTVPDPASDELLDTTNVRSQILTM
LVAGHETSAGVLAFALYELSRRPELVAAARAEIETRFADGDLSTIAYDDVAKLRTLRR
IVDETLRLYPVAPGFFREARHETTIGGGRYRFGPGDWVLVLTLHAHRDPATWGPDAGE
FQPDRWLPERMRSLDGRQVFKPFGTGLRACIGRQFAYHEIVLALAHILHTFEFTPDPG
YELDIAEQITLKPHRFRLRLNHR
>CYP103A1 Agrobacterium tumefaciens
MIANSSTDVSVADQKFLNVAKSNQIDPDAVPISRLDSEGHSIFA
EWRPKRPFLRREDGIFLVLRADHIFLLGTDPRTRQIETELMLNRGVKAGAVFDFIDHS
MLFSNGETHGKRRSGLSKAFSFRMVEALRPEIAKITECLWDDLQKVDDFNFTEMYASQ
LPALTIASVLGLPSEDTPFFTRLVYKVSRCLSPSWRDEEFEEIEASAIELQDYVRSVI
ADSGRRMRDDFLSRYLKAVREAGTLSPIEEIMQLMLIILAGSDTTRTAMVMVTALALQ
NPALWSSLRGNQSYVAAAVEEGLRFEPPVGSFPRLALKDIDLDGYVLPKGSLLALSVM
SGLRDEKHYEHPQLFDVGRQQMRWHLGFGAGVHRCLGETLARIELQEGLRTLLRRAPN
LAVVGDWPRMMGHGGIRRATDMMVKLSFDL
>CYP103A2 Agrobacterium tumefaciens
MITSSISGTDQQFQNATQPKELDPDAVPVSRLDSEGHEIFAEWR
PKRPFLRREDGVFLVLRADDIFLLGTDPRTRQIETELMLNRGVTRGAVFDLIRYSMLF
SNGEVHVKRRSAFAKTFAFRMIDALRPEITKLTEHLWDDVPRVDDFDFAEMYASKLPA
LTIASVLGLPFGDAPFFTRLVYNVSRCLSPSWGEDDFPEIEASAVELQDYVRAVVADR
SRRISDDFLSCYLKAVREEGTLSPIEEIMQLVFLILAGSDATRNAMVMLPTLLLQNPV
VWSSLCHDQSGVAAAVEEGLRFEPSVGSFPRLALEDIDLDGYVLPKGSFLALSIMSGL
RDERHYEHPQLFDIKRKQMRRHLGFGAGVHRCLGEALARIELQEGLRTLLRRAPSLRV
TGDWPRMIGHGGARRATGMTVNLGVDR"
>CYP103A3 Agrobacterium tumefaciens plasmid pTiAB2/73 vir
MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP
KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS
NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV
AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR
SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV
WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR
DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE
GEWPTVQGHGGVRRIAEMRVGFRRQI
>CYP104A1 Agrobacterium tumefaciens
MEERRVSISSITWRFPMLFAPVDDVTTIDDLTLDPYPIYRRMRV
QNPVVHVASVRRTFLTKAFDTKMVKDDPSRFSSDDPSTPMKPAFQAHTLMRKDGTEHA
RERMAMARAFAPKAIADHWAPIYRDIVNEYLDRLPRGDTVDLFAEICGPVAARILAHI
LGICEASDVEIIRWSQRLIDGAGNFGWRSELFERSDEANAEMNCLFNDLVKKHRSAPN
PSAFATMLNAPDPIPLSQIYANIKIAIGGGVNEPRDALGTILYGLLTNPEQLEEVKRQ
QCWGQAFEEGLRWVAPIQASSRLVREDTEIRGFIVPKGDIVMTIQASANRDEDVFEDG
ESFNVFRPKSAHQSFGSGPHHCPGAQISRQTVGAIMLPILFDRFPDMILPHPELVQWR
GFGFRGPINLPVTLR
>CYP104A2 Agrobacterium tumefaciens
MQLAPVDRVTTIDDLTLDPYPIYRRMRAQTPVVRVASVMRTFLT
KASDTKMVKDQPRRFSSDDPNTPMKPAFQAHTLMRKDGAEHARERMAMAKAFAPKTTA
EHWAAIYRDIVNEYLDRLSRGSTVDLFAEICGPVAARILAHVLGISEASDAEMIRWSQ
RLIEGAGNFGWRPEPFERANEANAEMNRLFDNLVEKHRAEPNPSAFAIMVTASDPIPM
SQIYANIKIAVGGGINEPRDALGTIIYGLLTNPEQFEEVKRQQCWGQVFEEGVRWVAP
IQASSRLVLEDTEIRGFLVPKGDTVMTIQASANRDEDVFDDGERFNVFRQNNAHQSFG
SGPHHCAGAQISRQTVGAIMLPTLFERFPNMTLTNPDAVQWRGFGFRGPISLPVTLI
>CYP105A1 Streptomyces griseolus
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVT
LYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPE
HGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVIC
RLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGA
LVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSL
VPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPD
ALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRP
GTTIQGVNELPVTW
>CYP105A2 Amycolata autotrophica
MTTDATDPRTTDAAPFPSNRSAPYRFSDGYAQLRDPPGPLRLGT
RYDGRQAWVVVIHEAARKLLASRFESADAHRTGFPFLTAGGRDMIGTNPTLFRMDDPE
HARLRRMTISHYTVKRIKTISEFVEEVVLVFLRRMTISGPTADLVSQFLIGAGHMVIC
RLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLQYLARLARTKRERPDDAIIS
RLVARGEILREEDISDAMLLLIAGHATDANLTSMSLYALADRSEQYAALRADRSLVPG
AVEDPLRYVAIADIATEDVPIRGRTIAAGNTQIAMGSSANLDHEYYEDPDALTARVED
LVHLAFGFGRHQCLGQNLARADQLREDLMTARNDPTLRLAVPVQSSARLEGTTIQGVN
ELPVTW
>CYP105A3 Streptomyces carbophilus
MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDAL
RPVTLYDGRRAWVVTKHEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGM
DPPEHGTRRRMTISEFTVKRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPS
MVICHMLGVPYADHEFFQDASKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTG
LLGKLVTHQLADGEIDRAELISTALLLLVAGHETTASMTSLSVITLLEHPDQHAALRA
DPSLVPGAVEELLRVLAIADIAGGRIATADIEIDGQLIRAGEGVIVTNSIANRDSSVF
ENPDRLDVHRSARHHLSFGYGVHQCLGQNLARLELEVILTVLFDRIPTLRLAVPVEQL
TLRPGTTIQGVNELPVTW
>CYP105B1 Streptomyces griseolus
MTTAERTAPPDALTVPASRAPGCPFDPAPDVTEAARTEPVTRAT
LWDGSSCWLVTRHQDVRAVLGDPRFSADAHRTGFPFLTAGGREIIGTNPTFLRMDDPE
HARLRRMLTADFIVKKVEAMRPEVQRLADDLVDRMTTGRTSADLVTEFALPLPSLVIC
LLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLEYLARLARTKRERPDDAIIS
RLVARGELDDTQIATMGRLLLVAGHETTANMTALSTLVLLRNPDQLARLRAEPALVKG
AVEELLRYLTIVHNGVPRIATEDVLIGGRTIAAGEGVLCMISSANRDAEVFPGGDDLD
VARDARRHVAFGFGVHQCLGQPLARVELQIAIETLLRRLPDLRLAVPHEEIPFRGDMA
IYGVHSLPIAW
>CYP105B2 Streptomyces tubercidicus strain R-922
MTTAERTEAERNTGSTGPSEDLAPLSPLAVPAARADGCPFDPAPGVERARREEPVTRATLWDGSTCWLVTRHQDVR
EVLGDPRFSADAARPGFPFLTAGGRVLATSKPTFIRQDDPEHARLRRMLTADFMVKKMEAMRPEVQRLADDLLDRM
TAGRNAADLVAEFALPLPSLVICLLLGVPYDDHEFFQDRSRLLLSLRSTAEEVRTAQADLQRYLSRLAAAKQREPD
DGIVSRLVARGELDFEEIASMGRLLLIAGHETTANMTALSTLALLRNPGQLARLREDPSLIKGAVEELLRYLTIVH
NGLPRVATEDVTLGGRTIRAGEGVLCTLNSANRDEDVFPGGDALDVGRDARRHVAFGFGVHQCLGQPLARVELQIA
VETLLRRLPDLRLGIPFEDVPFRHDMGIYGVHALPVAW
>CYP105B3 Saccharopolyspora erythraea NRRL23338
MTSTLDESTPDYPMPRARGCPFDPPPALRDLQRETPMARVRLWDGSTPWLVTRYADQRAV
LRDSHVSADMNHPTYPRQAPGGGTLSFIGMDDPEHARLRRMVGSAFAVKNVERMRPWVQR
IVDEAVDELLAGPRPADLVEEFALPVPSLVICGLLDVPYADHAFFQSNSKTMINRDSTPE
QRSQASGRLAEYLSDLLSSKMDTRGDDLRSRLCGRIEAGDLTLRQATEMAVLLLIAGHET
TANMIALSTLLLLRHPDQLALLRESDDPDVARRAVEEMLRYLNITHGGRRRVALEDVEVA
GQRVRAGEGLVLPNEIANRDPDAFPDPDRLDITREARHHVAFGFGVHQCLGQPLARLELE
IVYRTLYRRAPRLALAAGIEDIPFKHDGFVYGVYELPVTW
>CYP105C1 Streptomyces sp.
MTQAAPVTFSTVRENYFGPPAEMQALRHKAPVTRTAFADGRPGW
LVTGYSAARAVLSDSRFTARGEREHPAVPRAATLEDERCRRLIAGQFTARRMRQLTGR
TERIVREHLDAMEHMGSPADLVEHFALPVPSLVIAELLGVPPPDREHFQHDTLRWGGF
GRSTEEVTEAFVSLGGQLQRLVRLKRTEPGDDLLSGLIAADPALTDEELASIAFLLLV
AGHGTTAHQIALGAFLLLEHPDQLAALRADPALTESAVEELLRHLSVVHHGPTRAALQ
DADIEGTPVKAGEVVVVSLGAANRDPARFERPDAVDVTREDTGHLAFGHGMHQCLGRQ
LARIELRVALTALLERFPHLRLACPAAEIPLRHDMQVYGADRLPVAW
>CYP105D1 Streptomyces griseus
MTESTTDPARQNLDPTSPAPATSFPQDRGCPYHPPAGYAPLREG
RPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRSHPDFPVPAERFAGAQRRRVAL
LGVDDPEHNTQRRMLIPTFSVKRIGALRPRIQETVDRLLDAMERQGPPAELVSAFALP
VPSMVICALLGVPYADHAFFEERSQRLLRGPGADDVNRARDELEEYLGALIDRKRAEP
GDGLLDELIHRDHPDGPVDREQLVAFAVILLIAGHETTANMISLGTFTLLSHPEQLAA
LRAGGTSTAVVVEELLRFLSIAEGLQRLATEDMEVDGATIRKGEGVVFSTSLINRDAD
VFPRAETLDWDRPARHHLAFGFGVHQCLGQNLARAELDIAMRTLFERLPGLRLAVPAH
EIRHKPGDTIQGLLDLPVAW
>CYP105D2 Streptomyces griseus
LLIAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEEL
LRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSR
HHLAFGFGVHQCLGQNL
>CYP105D3 Streptomyces sclerotialus
LLIAGHETTANMISLGTYTLLRHPDRLAELRADPGLAPAAVEEL
LRMLSIADGMLRVATEDIEAGGTVIRAGDGVIFGTSVINRDETVYTDPDALDWHRPAR
HHVAFGFGIHQCLGQNL
>CYP105D4 Streptomyces lividans
MTDTDTTTNTHPAAPVAFPQDRTCPYHPPAAYDPLRTARPLARI
TLFDGRPAWLVTGHAAARRLLADQRLSTDRTRDGFPATSARLAAVRERRTALLGVDDP
EHRAQRRMVLPEFTLKRAGALRPSIRRIVGERLDAMIAQGPPADLVTAFALPVPSMVI
CALLGVPYADHEFFEEQSRRLLRGPLPADTRDARDRLEAYLGELIDRKRRAPGEGLLD
DLVRRQASEGATDREQLIAFAVILLVAGHETTANMISLGTYTLLTNPGRLAELRADPA
LLPGAVEELMRVLSIADGLLRMATEDIDVDGQTIRAGDGVVFSTSVINRDESVYPEPD
ALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALESLFDRLPTLRLAAPADEIPFKP
GDTIQGMLELPVAW
>CYP105D5 Streptomyces coelicolor
3343 MTDTDTTTNTDTTTNT
3295
HPAAPVAFPQDRTCPYHPPAAYDPLRAARPLARITLFDGRPAWLVTGHAAARRLLADQRL 3116
3115 STDRTRDGFPATSARLAAVRERRTALLGVDDPEHRAQRRMVLPEFTLKRAGALRPSIRRI
2936
2935
VGERLDAMIAQGPPADLVTAFALPVPSMVICALLGVPYADHEFFEEQSRRLLRGPLPADT 2756
2755
RDARDRLEAYLGELIDRKRRAPGEGLLDDLVRRQASEGATDREQLIAFAVILLVAGHETT 2576
2575
ANMISLGTYTLLTNPGRLAELRADPALLPGAVEELMRVLSIADGLLRMATEDIDVDGQTI 2396
2395
RAGDGVVFSTSVINRDESVYPEPDALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALE 2216
2215 SLFDRLPTLRLAAPADEIPFKPGDTIQGMLELPVAW*
2105
>CYP105D6 Streptomyces avermitilis
MNAALPMFERHDMTETEIRLTGSPAPSFPQDRTCPYQPPKAYEE
RRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGL
AFPLIGVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVSA
FALPVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFGELYTYLHGLVGRK
QAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE
QIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMN
RDAKAYENPDIFDARRNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA
VPLDEVPIKAGHDAQGPIELPVVW
>CYP105D7 Streptomyces avermitilis
MEIGKSKSSPARSFMTEPGTSVSAPVAFPQDRTCPYDPPTAYDP
LREGRPLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTR
RVALLGVDDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSA
FALPLPSMVICALLGVPYADHDFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRK
RKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPE
QLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVIN
RDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLA
APADEIPFKPGDTIQGMLELPVTW
>CYP105D8 Streptomyces tubercidicus strain I-1529
VTEAISYFQDRTCPYHPPAGYQPLRETGPLTHVALYDGRKVWAVTGHSEARALLSDQRLSSDRQNPAFPMPFERFA
SIAQVRTPLIGVDDPEHNTQRRMLIPSFSVKRVAALRPDIHRIVDELLDRMLAEGPPAELVSTFALPVPSMVICSL
LGVPYSDHEFFEGESRRLLRSRTAEEAKQARIKLEEYFTDLIAHKEKNPGDGLLDELIEERLRTGTLAHEDLVRLV
MILLVAGHETTANMISLGTFTLLEHPEQLAQLKAEESLMPTAVEELLRFLSIADGMLRVAKEDIEIGGQLIRADDG
VLFPTSLINRDEATYPSPDELDLDRSARHHIAFGFGIHQCLGQNLARAEMEIALRSLFTRIPGLRLAVPAAEIPFK
PGDTLQGMIELPLAW
>CYP105D9 Streptomyces sp. JP95
MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI
SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV
GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL
PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK
QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD
QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN
RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA
VPAEQVPVNAPFVLQGVSELPVTW
>CYP105E1 Rhodococcus fascians
MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL
VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR
HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV
PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK
IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE
ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR
GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL
EELQLTW
>CYP105F1 Streptomyces lavendulae
MSDTEQHAPTLPRQRTCPFSPPPELEELRRTDPISRMRFADDSP
GWLLTRHADVRAALADPGVSSHPGKAPQPWRNLAPEMRAEHYLPGFLIFMDPPDHTRY
RRLLTKWFTMRAIRKLEPRIEQIVTETLDAMEAQGGTVDLVQSFALPIPLLVICELMG
IRYEEREEFMDMVLRLQALDATPEELGALGARMNEFMMKLAAAKRANPGDDLLSHLAH
DPDADPALTDLEIAGIGVLMLIAGHETSANMLGVGTYTLLENADQWALLRDDISLIDR
AVEELLRHQTIVQQGLPRGVTRDMEIAGHQVKTGESLLASLPAANRDPAVFPDPDRLD
ITREHNPHLAFGHGIHLCLGMELARVEMRQAWRGLVTRFPGLRMAAAPEDIRWRDDQI
VYGVYNLPVTWDEAK
>CYP105F2 Streptomyces peucetius
VSETDQRPPTLPRQRTCPFSPPPELEELRGTDPISRMRFADDSEGWLLTRHADVRAALAS
RSVSSHPGRTPQPWRNLAPEMRAEEYLPGFLIFMDPPNHSRYRRLLTKWFTMRAIRKLEP
RIEQIVSDALDAMEAEGGPVDLVQSFALPIPLLVICELMGIRYDDRVEFMDMVLRLQDLE
ATPEELGALGAKMNQFMIDLCAAKRKNPGDDLLSHLIQDPDAEPALTDLEVAGIGVLMLI
AGHETSANMLGIGTYTLLQNPGQWDLLRNDIGLIDQAVEELLRHQTIVQQGLPRGVTEDM
EIAGHAIKPGETLLASLPAANRDPEVFPDPDRLDITREHNPHLAFGHGIHLCLGMELARV
EMRCAWRGLVKRFPDLRMAARIEDIPWRDDQIVYGVYKLPVTWGDAP*
>CYP105G1 Amycolatopsis mediterranei
MTTKVTENAPSTESLRSPLPPEFVRREDPFHVPPALVAVSERGP
VARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPRFKELSPEFAFPAPSLMIC
ELLGVRYEDRAEFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRANPAGDIIS
GLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPS
RIADAVEGLLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP
DLDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRN
DMLTYGVHSLPIAWDAP
>CYP105H1 Streptomyces noursei ATCC 11455 nyst
MSTEADARTAAPQCPVAFPLRRPGRPFPPPEYATYRGGAGLVRS
ELPSGPVWLVTRHEDVRAVLTDPRISADPSKPGFPKAGRTGGAPSQYEVPGWFVAMDP
PEHGRFRKTLIPEFTVRKVRELRPVIQQIVDERIDAMLAAGTSADLVESFALPVPSLV
ISSLLGVPKVDRDFFEDRTRVLVRLSSTDEERDKATQALLRYLGRLIQIKQRRPGDDL
ISRLIAAGTLSRQELSGVAMLLLIAGHETTANNIGLGVVQLLTNPRWIGDDRIVEELL
RYYSVADLVAFRVAVEDVEIGGQLIRAGEGIVPLIAAANHDATAFAAPSEFDPERSAR
SHVAFGYGVHQCLGQNLVREEMDIAYRTLFARIPSLTLAVPVEELPLKYDGVLFGLHE
LPVTWK
>CYP105H2 Streptomyces albus
LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD
MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY
GVHQCLGQNL
>CYP105H3 Streptomyces natalensis
MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS
QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS
PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV
ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD
LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET
LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA
RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN
ELPVRW
>CYP105H4 Streptomyces nodosus
MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS
ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD
PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL
VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED
LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM
LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA
RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH
ELPVTWS
>CYP105H5 Streptomyces griseus
MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR
PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR
FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL
GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL
LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS
VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA
FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVR
W
>CYP105J1 Amycolatopsis mediterranei rifamycin
MTETVAFPQDRTCPYQPAPGYEPLADRRPIAEVTLYDGRKAWAV
TGHELARKLLCDPRISSDRTNPAWPMVSAAAAVEFTDVQQKVIKLLTALVGVDGPAHR
ARRKLVQAGFTVKRIDSLRPKIQALVDRQIDEMIAEGAPVDLLKKFASPVPLIALCDL
LGIPHEDQDYFEKKAHQILFGPDAGGAYDELMAYLTKLIDKAEQNPGEEGFLQALLAE
RDPSSDVDHEEILQMFLIVLVTGHDTTSSSIGLGAFTLLQHPERLAELRADPSLMPAA
VDELTRFVVVPDGLQRVAADDIEVDADTTIRKGDGVFFLFSLINRDEEAYEDGDRLDW
HRPTFRDHLTYGFGTHQCAGMNHARAIMEIAFRRLIDRLPGLRLAVPADEVRVKPGDA
FQGLAELPVTW
>CYP105K1 Streptomyces tendae strain Tue901
MTETFGHDIPSFPMARECPMHPPAEYRKLRVQEPVSRVRMPDGQ
VAWLVLKHDLARKLLADPRVSADRLHPAFPGRLTAEQRTATERVRRLSTRRSMIHLDG
DEHGAHRKILTGEFSLRRIAALRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIRERAAASDALNDFLEDLVTEKERGEPTDD
LIGRLIARNRRTPVMTHDEIVGTAVMLLIAGHQTTANMISLGVVALLENPEHKARIAA
DPSLLPPAIEEMLRYFSVVENAPARVATEDIEIGGVTIRKDEGIVVSGLAADWDDEVF
EHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC
>CYP105K2 Streptomyces ansochromogenes
MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ
VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG
DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD
LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA
DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF
GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC
>CYP105L1 Streptomyces fradiae
MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS
PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG
EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD
LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL
ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL
QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL
AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA
LRPTTDVAGLRLKSDSAVFGVYELPVAW
>CYP105L2 Micromonospora griseorubida
MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA
LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR
PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS
RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL
LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA
TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG
QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW
>CYP105M1 Streptomyces clavuligerus clavulanic
MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW
DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ
HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT
LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS
RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA
LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP
DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR
HEVSSYGLGALPVTW
>CYP105N1 Streptomyces coelicolor
MTPPESPTASHTPGATPPRDFPIQRGCPFAAPAEYAALRTDDPV
ARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT
DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVST
SVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRD
DLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR
KDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQ
FDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQ
VVVKHDSATFGLEELMVTW
>CYP105N2 Streptomyces glaucescens cytochrome P450
LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL
LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD
NHHVAFGYGMHQCLGQNL
>CYP105P1 Streptomyces avermitilis
MPEPTADAPTVPKARSCPFLPPDGIADIRAAAPVTRATFTSGHE
AWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLL
AKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVPVE
RRAEFQDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDP
DGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPSLVGNAVEE
LLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRR
PAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGV
HELPVTW
>CYP105P2 Streptomyces peucetius
MSQPTAGAPAAPKARSCPFLPPDGIADIRAAAPVTRATFTSGHEAWLVTGYEQVRAVLRD
PSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFTVRRMQALRPNIQR
IVDEHLDAIEARGGPVDLVKTFANPVPSMVISDLFGVPAERRAEFQEIAEAMMRVDQDAA
ATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHD
TTACMIGLGTALLLDRPDQLALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGG
VRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAPHLAFGFGAHQCIGQQLARIELQI
VFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPVTW
>CYP105Q1 Streptomyces avermitilis
MADALAGRAPDATPPVAAYPMPRAVSCPLAPPPALQPLRDEQPI
TKVRIWNGSTPWLITRHADQRALLTDPRVSNDDRDPGFPYVNAHRAEIAHATPRLITN
TDAPEHTRLRRTVNAPFLIKRIEAMRPAVQRIVDGLIDDMLDGPNPADLLTALALPVP
SLVIAQLLGVPYADHEFFQRNSNLVLDNSVPAEEARAASGALAAYLDTLLAEKTAAPD
ADVLSEMGGRIKAGEMTHREAVHMGVAMLIAGHETTATMISLGTLALLEHPEQLAVLR
DAEDPKVIAAAVEELLRYLTIVHSGIRRVAKEDIEIGDRVIGAGDGLLFDLHAANWDS
EAFPEADRLDLSRPARHHQAFGYGPHQCLGQSLARLELQVVYGTLYRRFPTLRLAAPI
DRLAFHHTGTTYGVRCLPVTW
>CYP105Q2 Streptomyces sp.
LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA
182
183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC
350
>CYP105Q3 Streptomyces sp.
MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR
318
319
HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498
499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE
678
679
NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858
859
SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038
1039
GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218
1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW
1377
>CYP105Q4 Mycobacterium marinum MM4762
MSDTLASPSP
ETASGIPDYP MSRSAGCPFA PPPGVMALAA AKPLTRVRIW DGSTPWLITG
YEQVRELFSD
SRVSVDDRLP GFPHWNAGML STVHKRPRSV FTADGEEHTR FRRMLSKPFT
FKRVEALRPT
IQQITDEHID AMLAGPQPAD LVAKLALPVP SLVISQLLGV PYEDAEMFQH
HANVGLARYA
TGADTVKGAM SLHKYLAELV EAKMANPAED AVSDLAERVK AGELSVKEAA
QLGTGLLIAG
HETTANMIGL GVLALLVNPD QAGILRDAQD PKIVANAVEE LLRYLSIIQN
GQRRVAHEDI
HIGGETIRAG EGIIIDLAPA NWDAHAFTEP DRLYLHRAGA ERNVAFGYGR
HQCVGQQLAR
AELQIVYRTL LQRIPTLTLA TALEDVPFKD DRLAYGVYEL PVTW*
>CYP105Q4 Mycobacterium ulcerans
VSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGVMSLAAAKPLTRVRIWDGSAPWLITG
YEQVRELFSGSRVSVDDRVPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFT
FKRVEALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQH
HANVGLARYATGADTVKGAMSLHKYLAELVEAKMANPAEDAVSDLAERVKAGELSVKEAA
QLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAHDPKIVANAVEELLRYLSIIQN
GQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGR
HQCVGQQLARTELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW
>CYP105Q5 Streptomyces scabies SCAB11341
MAGTPTDAAS GTDGQLPEYP MPRAAACPLA PPPAAAGLRG
EHPISRVRIW NGSTPWLITR
HADQRTLLTD PRVSNDDHEP DFPHVNAHRA AIAPHTPKLI
TNTDAPEHTR LRRSVNAPFL
VKRIEAMRPA AQKIVDDLID EMLAGPNPAD LLTALALPVP
SLVIAELLGV PYEDHRFFQE
NSNRVLDNSL TAEEAQESSR ALGGYLDTLF RTKLEQPGDD
VLSEMGAKVR AGEMTHQEAV
SMGVAMLIAG HETTATMISL GTLALFEHPD QLAVLRDTEE
PRVVAGAVDE LLRYLSIVHS
GLRRVAKDDI EIDGRVIRKG DGLLFDLQTA NWDPNAFPEA
ERLDLGRPAR QHNAFGHGPH
QCLGQNLARL ELQVVYGTLY RRVPTLRPAV PVDRLAFHHT
GTTYGVTCLP VAW
>CYP105Q6 Mycobacterium vanbaalenii PYR-1
MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS
VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA
GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ
AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI
ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG
FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW
>CYP105Q7 Mycobacterium smegmatis
MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS
TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS
DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD
KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH
QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET
TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR
RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL
GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA
YGVYELPVAW
>CYP105R1 Streptomyces avermitilis
MTQTAAVTTAWPLHRTCPMSQPPALAAFRDGPPRQVLLRGDQPA
WLITRYADVRQALADPRLSVNDQHPNWPNRLLFPVPPRAVSFWRMDPPEHGAYRKMVA
AEFIAHRTQALRPLLQSITDELLDEMAAMPKPVDFHSVFALPLPCIAIARIFGVPDED
MSEFKENTSALLNQKEPEKAVQAFLATTAYLDGLARAKEREPKDDLLSRLVVNFVRPG
QLSHDDLVAMVRLMLVAGHETTANQIALSIFTLLDRPGVLAELRADPRLLTPVVDELL
RYWSIAQDNVVRTATEDLSVGDARIAAGDAVVISVPGANHDEAVFPDAADFDIHRDNS
RHLAFGHGPHFCPGGPLARTELEIAITSVFRRFPDLRLAIGRDQVPVHTDTLVYGLEC
LPVTW
>CYP105S1 Mycobacterium smegmatis
MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE
DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ
RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI
PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL
VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL
GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL
AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC
LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW
>CYP105S2 Mycobacterium vanbaalenii PYR-1
MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP
GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD
GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR
TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA
VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH
GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW
>CYP105T1 Burkholderia fungorum
MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV
TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM
DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV
TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD
GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL
LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP
AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP
LEELPFKREMYVYGLHALPVTW
>CYP105U1 Streptomyces hygroscopicus strain NRRL 3602
MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF
LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA
NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF
AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG
GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL
RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR
EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR
VPVAW
>CYP105V1 Streptomyces sp. HK803
MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG
KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT
AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV
LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV
GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA
AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD
VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD
VQGVRALPVTW
>CYP105W1 Micromonospora echinospora
MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR
VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA
ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF
ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD
HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF
TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL
AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW
>CYP105X1 Pseudonocardia autotrophica same as Amycolata
MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA
WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR
MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP
YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH
LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA
VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI
HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML
FGLHELPVTW
>CYP105X2 Amycolata autotrophica same as Pseudonocardia
LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL
>CYP105X3 Micromonospora inyoensis
LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL
>CYP105Y1 Rhodococcus sp. RHA1 Rha04313
MSKTVAVPYGLPMERDAGPFDPPRRITRLRETRPVSPMVFPDGHEGWLVTGYDAVRQLMADTRFSSRQDIGILHVPYETPGMPAATEPSPQMPGVFIAMDPPDHTRMRRKLAGAFTVKRMKQLEDHIIDVAERQLDAMARLTPPVDLVKEFALPVPSLVICELLGVPYADRDNFQVNSAKFLIKDQPLDDKMAAYGALSTYLADLVTRKRAAPGDDILSDLARDDDLTIEELTGAAFLLLLAGHETTANMLALGAFALLENPEQLTELRTDPDLLPDAVEELLRYLSVADIFYRYATEDIELGGETIRAGSTVVVSLLAANRDPQRFDNPDTLDIRRKARGHLSLGHGVHLCLGQQLARLEMRAGFEGLLRRFPTLGLAIPAGDVKLRTDMNIYGVHELPVTWTETSR
>CYP105Z1 Streptomyces scabies SCAB17851
MTTHPPHPPL PTLRPLLDPS PEYAKWRTEE PIRRVTIWGD
NSPWLITRHE DARVVLADPR
FSADATRDGF PGFRPQSPPR GPGQFFMMDP PDHTRLRRVL
IPDFTFRRIE QLRPAIARIC
GELLDAMTAD DATAADLVEA YALPLPSLAI CELLGVPYED
HDFFQRQANA FSSFSSGPEE
MMAARTALHT YLGDLLARRG REPADDLLTR LARDRVATGE
ISAPEAVGIA SLLLVAGHET
TANMFPLAVL DLLRHPAQLA ALRADPALWP GAVEELLRHL
TVTHAGLRRI ATEDVVVSGV
RIRAGEGVIV ALQAANRDPS AFTAPDTLDV RRTTTGHLAF
GHGLHQCIGQ SLARAELQVG
LPALFDRLPG LRTAGEPEDF TPAISAVHGV RSLPVSW
>CYP105AA1 Streptomyces tubercidicus strain R-922
MTGRSACGSGARSAPSVRTPASPPVGPSAAPVTPVTPSQPLTLL
EKDCPMTAMQPTARTQPMERTCPFSPPEGYRTLREEDPITQVTFPDGAKGWLVSRYSD
VRAVLADPRFGANGQQPPLPGMFLTMDPPEHTRFRRLLTGQFTVRRMRKLAPAVEQIV
AERLAEMAAAEGPVDLVQAFALPVPSLVICELLGVPYADREEFQENSSRMLRLDASQE
QFEQAQMAMYERIHQLVVAKRAHPTDDILSGLVQSGVLTDEEVTGVGVLLLIAGHETT
ANMIALGTMCLLGHPGQLASLRADPELMDDAVEELLRYLTIVQYGLRRMALEDVELGG
QRIKAGSVVVAALPSGNRDATHFSGDPETLDVRRPYSPHLAFGHGVHQCIGQQLARVE
MKAALSALIDRFPGLRLAVPAREVPMRDDMLIYGVHELPVTW
>CYP105AA2 Streptomyces tubercidicus strain I-1529
MTRTVPGPQALPTERDAGPFAPPRDISRMREARPVSPMVFPDGH
EGWIVTGYDAVRRLMADTRFSSRQDIGILHVPYETPGMPAPTEPSPQIPGLFIAMDPP
DHTRLRRKLTGAFTVKRMKQLEEHISDIVERQLDELTRLAPPVDLVKEFALPVPSLVI
CALLGVPYADRETFQVNSAKFLEKDVSLDEKMAAYTGLTTYLSELVTRKRAAPGEDIL
SDLARHDDLTIEELTGMAFLLLLAGHETTANMLALGTFALLEHPEQLAELRADPDLMP
GAVEELLRYLSIADIFYRYATEDIELGGETIGKGSTVVVSLLAANHDPQRFDNPDTLD
IHRTARGHLSFGHGIHQCLGQQLARIEMRAGFEGLLRRFPTLELAIPADEVKLKTDMN
IYGVHELPVTWTDTAR
>CYP105AB1 Saccharopolyspora erythraea NRRL23338
LRSQEPVKRVRTIGGGTAWLVTRHEDVRRVLSDPRMSSDRTMPGFPSLVPGRRAIVAENK
QAMIGMDGQEHAEARRAVIGEFTVRRINRMRPRIQEIVDECVDRMLAAGGPVDLVRELSL
PVPSLVICELLGVPYSDHDFFQSRSALMISRSTPPERRRDVVLELRRYLDELVAEKVREP
ADDLLGRQVAQQSEKGEVDREGLVSLAFLLLIAGHETTANMISLGTLALLDNPDQLARIT
EDPARTPAAVEELLRYFSIVDGATSRTALADIEIGGVLIREGEGVVAVGLSANRDPEAFD
SPDELDLDRQARNHVAFGFGAHQCLGQNLARVELQIVFDTLFRRIPGLRLADGLDGIRFK
DDALVYGAHEMSVTW
>CYP105AB2 Salinispora
tropica (marine actinomycete)
MTETASIATTRTASGQLTDAEFPVQRGCPFTTPTEYEQIREESSIAKVRLKNGGEAWWIA
GHELGRSVLADRRFSSDRRRDNFPFVSTDPETRAQLQSQPTSMLGMDGAEHAQTRRALMG
EFTVRRMAGLRPRIQQIVDQHIDEMLATPQRSVDLVEALSLPVPSLVICELLGVPYADHD
FFQGLTGPLLRHTTPPEVRLRIQEELNTYLGTLIDRKLTDPTDDLLSRQIAKHRDNGTFD
RASMVSLAFLLLVAGHETTANMISLGVVGLLQHPDQLVIIKDDPDKTPLAVEELLRYFTI
ADSVTARVATEDVQLGDTTINAGDGVVISGLAADRDPTVFAEPDRLDLERGARHHVAFGF
GPHQCIGQTLARMELRIVFDTLFHRIPTLRLAAPLDDIPFKSDAFVYGIEELPVAW
>CYP105AC1 Saccharopolyspora erythraea NRRL23338
MQKHAPHNADDVLESLPRDRPSGCPFDPPEGLAEIRGQRPLTRLVYGDGHVGWLATGHAV
VRAVLADRRFSSRYELMHFPVAMPGLPAQIPPAQVGDITGIDPPEHTRYRKLLTGKFTVR
RMRALTERVEQITAERLDAMQRLGPPVDLVEAYAQPIPALMICELLGVPYDRLEEFLGLV
AASGDRDLTPEEQFDAFAKIQEFVRELVPAKRAKPTDDLLSDLTTTELTDQELAGIGGLL
LAAGLDTTANILALGTFALLRNPEQIAALREGDADRAVEELLRYLSIAHTGMRSALEDVE
IDGTLIRAGETVTLSIQAANRDPRRFTDPDALDLRRHAAGHLSFGHGIHQCLGQQLARVE
MRVAFPALFNRFPGLRLAVAPEEVPLRGDMNIYGVHGLPVTWDGA
>CYP105 fragment Streptoalloteichus hindustanus
LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL
MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT
SGHLAFGHGVHQCLRQNL
>CYP106A1 Bacillus megaterium
MNKEVIPVTEIPKFQSRAEEFFPIQWYKEMLNNSPVYFHEETNT
WNVFQYEHVKQVLSNYDFFSSDGQRTTIFVGDNSKKKSTSPITNLTNLDPPDHRKARS
LLAAAFTPRSLKNWEPRIKQIAADLVEAIQKNSTINIVDDLSSPFPSLVIADLFGVPV
KDRYQFKKWVDILFQPYDQERLEEIEQEKQRAGAEYFQYLYPIVIEKRSNLSDDIISD
LIQAEVDGETFTDEEIVHATMLLLGAGVETTSHAIANMFYSFLYDDKSLYSELRNNRE
LAPKAVEEMLRYRFHISRRDRTVKQDNELLGVKLKKGDVVIAWMSACNMDETMFENPF
SVDIHRPTNKKHLTFGNGPHFCLGAPLARLEMKIILEAFLEAFSHIEPFEDFELEPHL
TASATGQSLTYLPMTVYR
>CYP106A2 Bacillus megaterium
MKEVIAVKEITRFKTRTEEFSPYAWCKRMLENDPVSYHEGTDTW
NVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSL
LAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSK
DRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDL
LKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDL
VPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFT
LNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEENLT
DSATGQTLTSLPLKASRM
>CYP106B1 Bacillus anthracis str. Ames
1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY
DDEQDVWNVF LYDDVNRVLS
61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE
QWKPRIQSIA
121 NELVKDIENC SEVDIVEQFA APLPVTVISD
LLGVPTTDRK KIKAWSDILF MPYSKEKFND
181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD
IISDLIRAEY EGERLTDEEI VTFSLGLLAA
241 GNETTTNLII NSFYCFLVDS PATYKEVREK
PKLISKAVEE VLRYRFPVTL ARRITEDTNI
301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK
FNIHRIGNEK HLTFGKGPHF CLGAPLARLE
361 AEIALTTFIN AFEKIALSPS FNIEQCILEN
EQTLKFLPIR LKPQ
>CYP106B2P Bacillus cereus ATCC 14579
1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS
PGIYEELRKE PNLILKAIEE
61 VLRYRFPVTL TRRITALSER ESPSPLGMG
>CYP106B3P Bacillus cereus ATCC 14579
LKEDTNIFGPF
1
MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA
61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT
>CYP107A1 Saccharopolyspora erythraea
MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG
YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR
KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD
EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV
QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQDQLALVRRDPSAL
PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF
DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL
LLRGIDHLPVRLDG
>CYP107A2 Streptomyces rochei plasmid pSLA2-L
MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA
FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT
RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL
GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL
IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL
VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER
FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS
FLRGIESLPVRLGR
>CYP107B1 Saccharopolyspora erythraea NRRL23338
MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAWLITRYEDVKQALLDPR
IAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHTRLRKLVVKAFTARRVEGL
RPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELMGVEDSRRDDFRSWTNVLVDG
SQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLEAVEDGDRLSEGELIAMVFLLLV
AGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPGAIEETLRYESPVANGTFRHTAEAV
RFGDVVIPEGELVWVALGAANRDGERFEDPDRFDITRETTGHVAFGHGIHFCVGAALARL
EAQIAVGRLLERFPDLRMAASPDDLRWRFSVLMRGLEKLPVRPGA
>CYP107B2 Streptomyces sp.
LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE
182
183
ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344
>CYP107C1 Streptomyces thermotolerans
MTALNLMDPEVLRDPFGAYAEIRAQAPLVRASYPWGAVQWLATR
YSDVKAVLTDPRLVNNPANVPEMHLPHPYEQALGDGGIPDEYVRYLAGSILSQDGPGH
LRLRRLSSRAFTVRRVNALRPRVTELAHRLLASLPDRAQDGVIDVLEDFSYPLSIDVI
CEIVGIPEEAREQWHTWGSAFYTMDPAVIGPAVRGMADHLHLLIEQRRATPTGDLLTG
LVQAEDEQGEPLTDEEIATLVLTFVTAGNETTAHLIGNGVAALLTHSDQLALLRSDRR
LLSQAVDELMRWCTPVQVTQPRYATEDLDVGGVTVRKGEQVVAVIGAAGHDPDRFPDP
ERFDITRNHRAPHEAHVGFGFGPHYCLGAALAHQETAIALDTLFDRFPSLALAVPPSA
LERQPFPGAWRLKSLPVRL
>CYP107D1 Streptomyces antibioticus
MTDTHTGPTPADAVPAYPFSLPHALDLDPHYAELRRDEPVSRVR
LPYGEGTAWLVTRMSDARIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHT
RLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICEL
LGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGA
LALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPAL
VPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA
DELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWK
QGMLIRGLERQIVSW
>CYP107E1 Micromosospora griseorubida
MTSAEPRAYPFNDVHGLTLAGRYGELQETEPVSRVRPPYGEEAW
LVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAF
TARRAESLRPRAREIAHELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDR
FTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS
LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELIPSAVEELTR
WVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN
QHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLE
LPVVW
>CYP107E2 Saccharopolyspora erythraea NRRL23338
MPEPRPYPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFS
RAAVLEKDEPRMRPGITGGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLV
DRMIEHGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDY
MDRMFGYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQ
IPNFVYVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVR
AGEPVLVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRT
LLTRLPGLRFAGGEDDVVWKEGMLVRGPSKLEVAWQSE
>CYP107E3 Salinispora
tropica (marine actinomycete)
MTIDQEIRKYPFCESPGIGIDPTYGLLRSTEPLARVQLPYGEVSWLATRYEDVKTVLTDP
RFSRAAAQGKDQPRTREEMTYEGIIGLDPPDHTRLRKLAGKALTARRVNAIRADAQRIAN
EYVDEMIAKGSPGDLVELFALPYPVTVICELLGVPFEDRAQFRIWTEGLTSTSEQLMVYA
EQLFGYMGKLVAQRREEPTDDLLGALVKARDEGDRLTEQELLSIAGVGLLLTGVETVSTH
IPNFVYALLTHPELMAQLRADRSLVPAAVEELLRMIPLNPAAMFPRYAVEDVTLSGITVR
AGEPVLVSLPGANRDPEVFENPETFDFTREQNPHVAFGHGPHHCLGAQLARMELQVALHT
VLDRFPDLSLADGDEGVSWKSGLLVRGPSRLLVAW
>CYP107F1 Streptomyces griseus
MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMA
YGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSR
LRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPGDFVARVSAPLPLITICEAL
DIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTL
ATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRL
PRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPD
ELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNT
TSIWRYPLALPVTW
>CYP107F2 Streptomyces avermitilis
MTPSDEAIMCPFDFSKGLEFDPSLAELMARDSITRIRLPYGDAD
AWLVTGFDAVRQVTTDQRFSRAGIMGSDYPRLTPEPIVSPESINVVDPPHSSRLRRLV
SQAFTKGHVERMRRRIVRLADTLLDEMAAQGPPADLAHHLSNRLPQHTICDVLGIEQD
DWPRMEQYVHQLLSTGPDSRQSAATAKSELREYFGGLVEKRRSSPGNDLISALAAAKD
GEDVLDDQELAVMALTLMLSGHDTATCQISNICYLLLTRPELMKHLRSRPDTLTAVLN
EMLRFIPFRKGVGIPRVAVEDAEVDGVKIRAGDFVHVSYLTANRDPERYPDPDAIDPD
RPSLPHMTFGWGGHRCIAVPLAMAELEVAIGRLLERFPELRLAVPPEEVRWDTETIRR
FPIELPVAW
>CYP107G1 Streptomyces hygroscopicus
MSTTDQGETGKACPYPFAEMERLEIHPEYNRLRDAGELGRVLML
DGREAWLAASWEDVAKVFVDPRFSRSATLGKDVPRVLPAIQDQPVIMLMDPPEHTRLR
RVATKALTSRRMEALRPRTQEVADDLIDKMLAKGAPADLMEDFALPLPIIMICELLGV
PIEDQTKFRTWSDQMLSNGAYSQEVVMAAGQSLYLYLSELIAERRKQDTNDLLGSLVR
ARDKDDRLSETELVGFAVTLLIAGYETTANAIGNSVYTLLTHPEKLAELRKDLSLIPK
AVDELLRIIPIAKQASWVRMAVEDVELSGTIVKAGEAVAIQTHSANTDPKVYDHPEEI
DFHRTSNPHMSLGHGAHHCMGAQLVRVEMQTALGSLISRIPALRFAVPEPRIKFLRGR
LVPSLEALPLTW
>CYP107H1 Bacillus subtilis
MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG
YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP
RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE
WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD
KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL
RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP
HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV
TFE
>CYP107J1 Bacillus subtilis
MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL
GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP
DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS
EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD
LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ
QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF
PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM
KWKGNFLMRALEELPISF
>CYP107J2 Bacillus anthracis str. Ames
1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL
FVNKTELGAE WLITRYEDAL
61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS
LVQKVFTPKM
121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD
YSFPLPIIVI SEMLGIPKED QAKFRIWSHA
181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL
VSALILAESE GHKLSARELY
241 SMIMLLIVAG HETTVNLITN TVLALLENPN
QLQLLKENPK LIDAAIEEGL RYYSPVEVTT
301 SRWADEPFQI HDQTIEKGDM VVIALAAANR
DETVFENPEV FDITRENNRH IAFGHGSHFC
361 LGAPLARLEA KIAITTLFER MPELQIKGNR
EDIKWQGNYL MRSLEELPLT F
>CYP107J3 Bacillus cereus ATCC 14579
1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV
NQVEIGKEWL ITRYEDALPL
61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV
QKAFTPKMIA
121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS
FPLPIIVISE MLGIPKEDQA KFRIWSHAVI
181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK
RKEPKEDLVS ALILAESEGH KLSARELYSM
241 IMLLIVAGHE TTVNLITNTV LALLENPNQL
QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR
301 WAAEPFQIHH QTIQKGDMVI IALASANRDE
TVFENPEIFD ITRENNRHIA FGHGSHFCLG
361 APLARLEAKI AITTLFNRMP ELQIKGNREE
IKWQGNYLMR SLEELPLTF
>CYP107J4P Bacillus cereus ATCC 14579
1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK
EQEDKLSNNE LLSTIWLLII
61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF
ISRLASEDMT
121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE
TLNISREENN HLAFGAGIHH CLGAPLARLE
181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK
IRSLVNLPVV F
>CYP107K1 Bacillus subtilis
MQMEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATY
PAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHT
RLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELM
GIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKL
VHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMI
ATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEI
LNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKAAFEEIS
>CYP107L1 Streptomyces venezuelae
MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTR
LRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISEL
LGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALV
RTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLL
DGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHR
FDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPN
PMIRGLKALPIRWRRGREAGRRTG
>CYP107L2 Streptomyces avermitilis
MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEG
WLVVGHEEARAALADPRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAF
TMRRVEALRPRIQEITDGLLDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTF
RALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRL
SGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGAVEEVLRF
EGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQGH
LAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW
>CYP107L3 Streptomyces tubercidicus strain I-1529
VSEDRIVDLAALGEEFTRDPHPVYAELRARGPVHRVRLPEGFEAWLVVGYEAARAALSDPRLSNDWRRAAGADEGD
PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPGGRADLVEDFAFPLPAAVICELL
GVPYADRKTFHEWSTEVTKRSGGPRAEAAMGELAGYLMRLLEEKGRRPGDDLLSALIRTTGEDGDRLSSDELLGMA
VLLLIAGHETTAGLISNGMLALLRHPDQLAALQADFGLLDGAVEEMLRHSGPTGTSLHRFTTGPVDIAGTRIPGGG
ELVLIGNTPANHDPGRYPDPGRFDIRRDHRGHLAFGHGIHYCFGAPLARLEARTAIRTLLQRCPGLALDAAPDELV
WHHSAMMRGLPHVPVRTVPAPAAPAPQVHQVSSAH
>CYP107L4 Streptomyces tubercidicus strain R-922
VSEDRIVDLAALGEDFTRDPHPVYAELRDRGPVHRVRLPEGFEAWLVVGYEAARAALADPRLSNDWRHAAGAGAGD
PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPDGRADLVEDFAFPLPAAVICELL
GVPYADRKAFHGWSTEVTKRSGGPQAEAAMGELAGYLVRLLEDKGRRPGDDLLSALLRTTGEDGDRLSSDELLGMA
VLLLIAGHETTAGLLSNGMLALLRHPDQLAALHADFDLLDGAVEEMLRHSGPTGTSLHRFTTAPVDLAGTLIPGGG
ELVLIGNTPANHDPGRFPDPGRFDIRRAPHGHLAFGHGIHYCFGAPLARLEARTAIRALLERCPGLALDADADRLV
WHHSAMMRGLPHVPVRVRPAPGTPAAQVHHASSAR
>CYP107L5 Streptomyces sp.
LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE
182
183
PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344
>CYP107L6 Streptomyces sp.
MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL
ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI
TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY
AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET
TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT
VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA
LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*
>CYP107L7P Streptomyces narbonensis
MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT
(deletion)
ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD
AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD
VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*
>CYP107L8 Streptomyces sp. HK803
MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI
VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP
RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV
PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS
AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY
DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT
RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV
RSLPVRW
>CYP107L9 Streptomyces peucetius
MTIVDLADYGPDFTANPYPYYERLRASAPAHRVRGADGGEFWLIVGHEEARAALGDARLS
KSPATMGTTMLDEQVIGPNLLVVDPPDHTRLRKLVVREFTPRRAEALRPRVQRITDDLLD
AMVPAGRADLVDALAFPLPIVVICELLGIPAADRDAFRTWSNEVVAPTSPETGEDAVRQL
GAYLDGLIADKRCAGPTDDLLSALIRTKDEDGDRLSFTELRALAYLLLIAGHETTVNLIS
NGVRALLAHPDQLAALRADFSLLDGAVEEMLRYDGPVETATVRFSAAPVPVGDLVIPPGE
VVL
SAWRPPTATPPATPDPTASTSAGTPAAISPSGTASTSASALRWPAWRPGSPSAPSWS
AAPPSPWTKRRTRTNGSRAS*
>CYP107M1 Actinomadura hibisca
MPSSKDAPTVDPRPDVTPAFPFRPDDPFQPPCEHARLRASDPVA
KVVLPTGDHAWVVTRYADVRFVTSDRRFSKEAVTRPGAPRLIPMQRGSKSLVIMDPPE
HTRMRKIVSRAFTARRVEGMRAHVRDLTSGFVDEMVEHGPPADLIAHLALPLPVTVIC
EMLGVPPEDRPRFQDWTDRMLTIGAPALAQADEIKAAVGRLRGYLAELIDAKTAAPAD
DLLSLLSRAHADDGLSEEELLTFGMTLLAAGYHTTTAAITHSVYHLLREPSRYARLRE
DPSGIPAAVEELLRYGQIGGGAGAIRIAVEDVEVGGTLVRAGEAVIPLFNAANRDPEV
FADPEELDLGRTDNPHIALGHGIHYCLGAPLARLELQVVLETLVERTPALRLAIDDAD
ITWRPGLAFARPDALPIAW
>CYP107N1 Streptomyces lavendulae
MTGPEAAVRGCPFGAGEAPAYPFHAPDRLEPDPYWEPLRRERPL
QRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLAVAPGAPRFLPHQPPPDAVLSVEGP
DHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAMEEMGPPADLVEDFSLPFAVSMI
CELLGVPPEDRKRFCVWSDALLTTTAHTPAQVRDYMMQMHDYLGGLVAQRRVRPTADL
IGSLVTARDEEDKLTEGELVRLAEAILIAGYETSASQIPNFLYVLFRHPQLLERIRND
HDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGETVVPSMGAANRDPELF
TDPDELDLARRPNPHLGFGAGPHHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESL
SWKEGLMVRGMHTMPVTW
>CYP107N3 Streptomyces peucetius
VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW
LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT
PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT
WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE
LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV
DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP
HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*
>CYP107P1 Streptomyces coelicolor cosmid H10
MTAATDGPHVSGPAFDPWDPAFVADPYPAFAELRARGRVLYYEP
SDQWLVPHHADVSALLRDRRLGRTYQHRFTHEDFGRTPPPPEQEPFHTLNDHGMLDLE
PPDHTRIRRLVSKAFTPRTVERLKPYVHGLADDLVARLVAAGGGDLLTDVAEPLPVAV
IAEMLGIPESDRAPLRPWSAEICGMYELNPSEETAAKAVRASLDFSDYLRALIAARRK
EPGDDLISGLIAAHDEDDRLTEQEMISTCVLLLNAGHEATVNATTNGWLALFRHPDQL
AALRADHSLVPSAVEELMRYDTPLQLFERWVLDEIEIDGTTLPRGAEVAMLFGSANHD
PAVFTDPERLDLTRRDNPHISFSAGIHYCIGAPLARIELAASMTSLLKRAPGLRLAAE
PERRPNFVMRGLTELRVEL
>CYP107P2 Streptomyces avermitilis
MAAAFDLAFDPWDPAFLADPYPAYADLRAKGRVHYYEPTNQWLV
PHHADVSALLRDRRLGRAYQHRYTHEDFGRTAPPAEHEPFHTLNDHGMLDLEPPDHTR
IRRLVSKAFTPRTVEQLKPYVAKLAGELVDRLVAAGGGDLLADVAEPLPVAVIAEMLG
IPESDRAPLRPWSADICGMYELNPPKDVAAKAVRASVEFSDYLRELIAERRKEPGDDL
ISGLIAAHDEGDRLTEQEMISTCVLLLNAGHEATVNATVNGWYALFRNPDQLAALRAD
HSLVPAAVEELMRYDTPLQLFERWVLDEIEIDGTTVPRGAEIAMLFGSANHDPEVFRN
PEKLDLTREDNPHISFSAGIHYCIGAPLARIELAASMTALLEKAPTLGLVAEPKRKPN
FVIRGLEGLSVAV
>CYP107P3 Streptomyces peucetius
MLGIPVPDRPLLRPWSADICGMYELNPSQETAARAVQASVEFSAYLRELIAARRAEPGED
LVSALIAAYDEGDRLSEQEMISTCVLLLNAGHEATVNTTVNGWWTLFRYPEQLAALRADH
SLLSTAVEELMRYDTPLQLFERWVLDDIEIDGTLVPRGCELALLFGSANRDGARFDHPDE
LDLARQDNPHVSFGAGIHYCLGAPLARIELAAT
FGERCGSARRCGSRRSHGGRGAL*
>CYP107Q1 Amycolatopsis mediterranei
PVPLSIVSRDRVSIQRLACKVFGETRSGPPGRASFVLIAPRRPQ
TVHKGHNSEHCQVGGCSTGRPLPTVRNRACRTRAGRPRRHQEGMAMTATAKPSAKPVD
LFSPEVVADPFGWYARLREEPLPHTGTLNLGTMMGGPDMWLATRYEDVLTVLTDPRFL
TNPPADSPLADIRDGVFKAMNFPEDLIPWMANKLNTADGEDHTRLRKLVSYALTARRV
NALRPRVEKITEDLFDRMAEQGKDGSPVDIVEEFCFPLPVTVICELVGIDEPDRAAWH
AWGNAMATMDGPKIPPALRECIALSRELMARRRVEPKDDLVTALVQAQADDPGRVSDD
EIVGILFSLVTAGHQTTTYLIGNSVLFLLEQPEQLARLKAEPALWAQAVRELQRLGPL
QFTQARFPSEDVELGGVTIPRGTPVAPLLLAANTDPRKFPEPDKLVVDRLSVANEMHL
SFGKGIHRCLGQHLAYQEAEVALHGLFTRFPDLALAVPRDEIPWILRPAFTRTKTLPL
KLA
>CYP107Q2 Amycolatopsis mediterranei
MTTTAETSAEPVDLFSPEVVADPWGAHAAVREAPTLQIGGFMGG
PPMYLAARYEDVRQVLMDQRFQCNPLADSPAEDIRNGVFRHLDMPEELIPWLKNLINA
SDGEEHARLRKLVSYALTAHRVGKFRPRVEELTAELLDKLEAAGGDGTPIDLVESFCY
PLPVTVICELVGVDHEDRPQWRAWSDAMATLDGKRLPEEVRKTLAAARGMIERRRAEP
KDDMVTALVEAQAKNPGIATDDELVGVLFSLVTAGHQTTTYLIGNSVLALHEHPDQLA
RLKADPSLWPQAVRELQRLGPIQFGQPRFATEDIEVGGTVIPRGMPVVPLIMAANSDP
RKFPEPEKLQIDRLAVGSESHLGFGKGIHRCLGQHVAYLEAEVALRGLYTRFPDMTLA
VPREEIPWILRPGFTRTKDLPVRLARPAS
>CYP107R1 Streptomyces maritimus
MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE
AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA
GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD
REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR
EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE
ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID
RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR
GPKTLPVKW
>CYP107S1 Pseudomonas aeruginosa
VPDRKLRLGEELISPLHALYDGLQVDGAPRPAHRAAEHPVWVVTRYRDAR
KVLNHPGVRRDARQAAELYAKRTGSPRAGIGEGLSHHMLNLDPPDHTRL
RSLVGRAFTPRQVERLQPHIERITEALLDAMAGREQADLMADFAIPLTI
AVIFELLGIPEAEREHARQSWERQAELLSPEEAQALADAQVDYLRVLLE
AKRRQPADDVYSGLVQAADESGQLSEAELVSMAHLLMMSGFETTMNMIG
NALVTLLVNPEQLALLRAQPELLPNAMEELVRHDSPVRASMLRFTVEDV
ELDGVTIPAGEYILVSNLTANHDAERFDDPDRLDLTRNTDGHLGYGFGV
HYCVGASLARLEGRIAIQRLLARFPDLQLAVPHAELQWLPITFLRALIS
VPVRTGCSAPANTASHANPIERIAQ*
>CYP107T1 Streptomyces coelicolor
MGSAPRLIVSLTGGPMTAPTYEELAALRAVGAVHRVFVPGSGESRLVVTRDAARAALTDPRL
16234
16235 RNDIRHSASWDSDGGHAIGHNMLQSDPPQHTRLRRLVAGHFTPGRTAALRPRVERIAHDL
16414
16415
LDALPPAGTADLVARYALPLPVTVICELLGVPESDRGTFHTWSNELVMPTSPEAAGSA 16588
16589
ATALTGYLTELTDAKRRTPDGTLLGDLVAAADSGELTPGELLGMAFLILVAGHETTVN 16762
16763
LISATVHGLLTHPGQLARLRAEPELTEAAVEESLRYHSPVHASAFRFAAEPLELAGTAIA 16942
16943
AGDPVLVSLAAASRDPAHFPDPDRFDIGRRPRGHLGFGHGPHHCLGAPLARVEAAVAVRL 17122
17123 LLDRHPALALAAGPATLTWRTSTLLRGLVELPVRLG*
17233
>CYP107U1 Streptomyces coelicolor
MTGSSSAPVPELFSWEFASDPYPAYAWLREHAPVHRTRLPSGVEAWLVTRYADAKQALADP
8557
8556 RLSKNPAHHDEPAHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEF
8377
8376
APRVQELADGLIDRFADTGSADLIHDFAFPLPIYAICDLLGVPREDQDDFRDWAGMMI 8203
8202
RHQGGPRGGVARSVKKMRGYLADLIHRKRAALPPEPAPGEDLISGLIRASDHGEHLTEN 8026
8025
EAAAMAFILLFAGFETTVNLVGNGTYALLTHPEQRERLQTSLAAGERGLLETGVEELLRY 7846
7845 DGPVELATWRFATRPLTIGGQDVAAGDPVLVVLAAADRDPERFTDPDTLDLARRDSQHLG
7666
7665
YGHGIHYCLGAPLARLEGQTALATLLTRLPDLRLAADPAELRWRGGLIMRGLRTLPV 7495
SFTPPASSAGNGPSPTQK*
>CYP107U2 Streptomyces avermitilis
MAGSARRRGRHGGGVGTVAGSAAGTRRLQRERGSRYRHPVNAPH
SEPELFTWEFATDPYPAYAWLREHAPVHRTTLPSGVEAWLVTRYADAKQALADARLSK
NPVHHSEDAPGKSKTGIPGERSANLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAP
RVQELTDHLIDQFAQTGSADLIHEFAFPLPIYAICDLLGVPREDQDDFRDWAGMMIRH
GGGPRGGVARSVKKMRGYLAELIHRKREALPADPGPGEDLISGLIRASDHGEHLTENE
AAAMCFVLLFAGFETTINLIGNGTYALLRNPQQRARLQQSIERGEQDLLDTGIEELLR
YDGPVELATWRYATEPLDMGGQRIASGDPVLVVLAAADRDPARFDEPDTLDLSRSDNQ
HLGYGHGIHYCIGAPLARLEGRTALATLLRRLPDLRLAADPADLRWRGGLIMRGLRNL
PVEFTAT
>CYP107U3 Streptomyces peucetius
MTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDAFIDKGEADLIHEFAF
PLPIYAICDMLGVPREDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLAELIHRKREQ
PGDDLISGLIKASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGVYALLCNPEQRERL
QASLAAGERGLLETGVEELLRYDGPVELATWRFATEPLTVGGQRIAAGDPVLVVLAAADR
DPERFADPDTLDLSRSDNQHLGYGHGIHYCLGAPLARLEGQTALATLLRRVPDLRLTGDP
ADLRWRGGLIMRGLRTLPVAWGAGGAPGGIKPGTAQTN*
>CYP107U4 Streptomyces scabies SCAB54411
MTNQPAPSSA VPTGTGAPEL FTWEFATDPY PAYAWLREHA
PVHRTRLPSG VEAWLVTRYG
DAKQALADGR LSKNPAHHAE PAHARGKTGI PGERKAELMT
HLLNIDPPDH TRLRRLVSKA
FTPRRVAEFA PRVQELTDRL IDGFADRGEA DLIHEFAFPL
PIYAICDLLG VPREDQDDFR
DWAGMMIRHG GGPRGGVARS VKKMRGYLAD LIHRKREGLT
DHPAPGEDLI SALIRASDHG
EHLTENEAAA MAFILLFAGF ETTVNLIGNG TYALLTHPEQ
RARLQTSLAA GETGLLETGV
EELLRYDGPV ELATWRFATE PLTLGGQDIA PGDPVLVVLA
AADRDPARFD DPDTLDLSRR
DNQHLGYGHG IHYCLGAPLA RLEGQTALAT LLTRLPDLRL AVDSADLRWR
GGLIMRGLRT
LPVEFTPRKR S
>CYP107V1 Streptomyces avermitilis
MSGASARCPFSGAGGGTDVLPLPADPGTAAGAPAPGPPDAPAAP
APRTADRSAPHAADPHAPSTADLPRFPFPGLSGIPLDPVLLDRYRGEPLVPVGLANGR
EALLVTRYADVRTVLSDDRFSREAWANGTLFARRSGALALVTSDAPTHTRRRSRVQSR
FTHRRAEEDRPRIARIAAELLDSLQAADTGRPVDLIAEFTTPFPYRVICEMLGVPVAD
LDRLLPSVTVMMSAGRFSADEAARAHEVMYGYFFGQLAARREAIAAGCPGDDLLTSLL
SAPRETRLSDEEIVVFGFGLMMAGGETTASHLAMCVLQVLGTPGLADRLRRDASAVPA
VVEELLRWVWFAGTGGQPHVALEDVELAGRVLPAGQVVIPLTDAANRDPGVFPDADEF
RPDRAPNPHIGFGHGRHMCLGAAHARVELQEGLTAVLERLDHLELAVEPAELRWRDQM
FMRGVWELPVRWHTKEDGRC
>CYP107W1 Streptomyces avermitilis
MAEAPSEPIAFPFPDPPSVCELPPELAEIRDGQSVVEVKFPDGI
SGWMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRK
LVTKAFTARRVETLRPRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVP
AGDQDTFHAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAIS
DGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAIPKAV
DELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL
NVTRENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSAS
IIRGLESLPITW
>CYP107X1 Streptomyces avermitilis
MDPAEGLLADPYAVYDRLRDTAPVHRIAGTDGKPAWLVTRYDDV
REGLANPLLSLDKKHALPGNYRGLALPPALDANLLNMDAPDHTRIRRLVGRAFTLRRV
EQLREPVRETAHRLLDALGTHGSTDLIASYAAPLPITVICDLLGVPDEHRRDFRAWTD
PLVTPDPARPDVARESVVSLLGFFTGLLADKRKNPADDLLSDLIAVQEEGDRLTEDEL
MSLAFLILFAGYENTVHLIGNAVLALLRHPEQLAALREDPARLPDAVGEFARYEGPAL
LAIRRFPVRDVTIGGVTVPAGETVLLSLSAANRDPSRFPDPDRLDLGRDAAGHLALGH
GVHYCLGAPLARLETEVALAALLERFPDLALAETEPRRRPSLRARGLLALPVTY
>CYP107X2 Saccharopolyspora erythraea NRRL23338
MRPVEIDDEFVTCPHAAYARLREQGPVHRAVAPDGSRVWLVTRYDDVRAALADSRLSLDK
AHATDGYRGLSLPPALDANLLNMDAPEHTRLRRTVTRAFTAHRTELLRPRVQEIADELLA
AVAGQERAELMSAFAGPLPITVICELLGVDARDRPDFRAWTDEMLAPSTPDRARDSLRSL
YAFLVDLIARKRAEPGADMPSTLVGLRDEDGSLTEDELTSTAFLVLFAGYENTVNLIGNG
LAALLARPAQLAAVRSDRGLLPSTVEELLRFDPPPQLSIRRFPKEDLEIGGVRIPAGDTV
LLSLVSAHHDPARFTSPGELIPDRADNAHLAFGHGPHFCIGAPLARMEAEVAFSTVLTRF
PALSLAVDPAELRWRPSFRNRGLRELPVRLS
>CYP107Y1 Streptomyces avermitilis
MDFGADPYPEYAWLRAEEPVRQVLEGRGLYGLLVTRYEDVRKLL
SDPRMSKDPRNAPLDWQEAGKGRPLEDRTGLGTHLLTTDAPEHTRLRRLVSTAFTARR
VEGLRAQVQHITDGLLDTIVPRGQAELIGDFAFPLAITVICELLGVPKADQDVFRQWT
KDFRRWTNTDSAQADRGDARPVGLRDLLEYLTRLVDKRRQDPADGLVDALIAARDDDD
RLNEAELLSMMSLLLVGGFETTVNLIGNGTLALLRHPDQLALLRERPELVDSALEEML
RYDGSFETATWRFPLEPIEVAGTRIEKGHPVLLSLASANRDGAKFPAPDDFDVTRADP
AHVAFGRGAHFCLGAPLARLEGRIAFHGLLRRLPGLALSVPPEQLRWQRSLTVRGLEA
LPVTFDA
>CYP107Z1 Streptomyces rimosus ssp. paromyceticus strain
R-2374
MTTSPTESRAATPTGSTASPSTASAPATTPSAATSSDTTYPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG
TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLTPYLADTIL
TSDPPDHTRLRRLVSRAFTARRIQDLRPRVEQITDALLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR
TLWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH
ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA
ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLELALTPEQLEDQERL
RQPGTWRLRRLPLKLHARS
>CYP107Z2v1 Streptomyces albofaciens strain
C-0083
MTTSPTESRAATPPDSTASPSTAAAPATTPSAAASPDTTSPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG
TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADQDPRARLIELFGIPEDLAPYLTDTIL
TSDPPDHTRLRRLVSRAFTARRIQDLRPRVERITDELLARLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR
ALWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRADLRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH
ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA
ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERL
RQPGTWRLRRLPLRLHAES
>CYP107Z2v2 Streptomyces rimosus ssp.
paromyceticus strain BOEH-4355
MTTSPTESRAATPPDSTASPSTASAPATTPSAAASPDTTDRTTLPSYVGLHPGEPNLMEPELLENPYTGYGTLREQ
APLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLAPYLTDNILTSDPP
DHTRLRRLVSRAFTARRIQDLRPRVERITDELLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDRALWRR
FGADLASLNPKRIGATMPEMISHIHELIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGHETTAH
LISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYALEDTEVAGVQVRQGEALMFSLVAANHDP
RHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERLRQPGT
WRLRRLPLRLHAQS
>CYP107Z3 Streptomyces sp. strain IHS-0435
MTELADSPFSEHVGKHPGEPNVMEPALLTDPFTGYGELREQGPVVRGRFADDTPVWFITRFEEAREVLRDHRFANA
PAFAAGGGSGDTPSNRLMEIMGLPEHYRVYLANTILTMDAPDHTRIRRLVSRAFTARKITDLRPRVEDIADDLLRR
LPEHAEDGVVDLIKHYAYPLPITVICELVGIPEEDRLQWRDWGSAFVSLQPDRLSKAFPAMIEHIHALIRERRAAL
TDDLLSELIRVHDDDGGRLSDVEMVTMVLTLVLAGHETTAHLIGNGTAALLTHPDQLHLLKSDPELLPRAVHELMR
WCGPVQMTQLRYATEDVEVAGVQVKQGEAVLAMLVAANHDPRHFADPARLDLTRQPAGRAENHVGFGHGMHYCLGA
SLARQEGEVAFGNLLAHYPDVSLAVEPDALQRVPLPGNWRLAALPVRLR
>CYP107Z4 Streptomyces lydicus strain NRAB-0114
MSASTSSPLSAHVGKHPGEPHVMDPALISDPFGGYGALREQGPVVRGRFFDDSPLWLVTRFEEVRQVLRDQRFVNN
PADPALGVAPEDSPQLRALAMLGIPEHLHGYLLNSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVAQITAELLD
RLPEHAEDGVVDLIEHFAYPLPITVICELVGIAAEDRPQWRSWGADLVSVDPDRLGRTFPAMIDHIHALIGQRRAA
LTDDLLSELIRTHDDDGSRLSDVEMVTLVLTLVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHVTQLRYAAEDVDLAGTRIRRGDAVQAVLVSANHDPRHYTDPERLDLTRQPAGRAENHVGFGHGAHYCLG
ASLARQEGEVALGALFDRYPDLALAVAPEELERTPVPGTWRLTSLPVRLG
>CYP107Z5V1 Streptomyces lydicus strain
NRRL-2433
MSALPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFVDDSPVWFVTRFEEVREVLRDQRFRNN
PVSSAPDADPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVAQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRKGDAVQLILVSANRDPRHYTEPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLR
>CYP107Z5v2 Streptomyces chattanoogensis
DSM-40241
MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLG
>CYP107Z5v3 Streptomyces lydicus strain
R-401
MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR
>CYP107Z5v3 Streptomyces kasugaensis strain
A/96
MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR
>CYP107Z6 Streptomyces sp. strain I-1525
MSALSSSPFAEHIGKHPGEPNVMEPALINDPFGGYGALREQGPVVRGRFMDDSPVWFVTRFEEVRQVLRDQRFVNN
PASPLLGSQVEEMPMVKLLEQMGLPEHLRVYLLGSILNSDAPDHTRLRRLVSRAFTARKITGLRPRVEQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRAWGADLVSLEPDKLSTSFPAMIDHTHELIRQRRGA
LTDDLLSELIRAHDDDGSRLSDVEMVTMVFALVFAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYASEDIDLAGTPIRKGDAVQLILVSANFDPRHYSDPDRLDLTRHPAGHAENHVGFGHGMHYCLG
AALARQEGEVAFGKLLAHYPDVALGVEPEALERVPMPGSWRLNSLPLRLAKR
>CYP107Z7 Streptomyces tubercidicus strain DSM-40261
MSAISSSPFAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVLPGRFMDDSPVWLVTRFEEVRQVLRDQRFLNN
PAASSPGHSIDESPTARLLDMMGMPEHFRPYLMGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQLADELLA
RLPEHAEDGVVDLIKHFAYPLPITVICELVGIPEADRPQWRKWGADLVSLQPERLSTSFPAMIEHIHELIRERRGA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLVKDDPELLPRAVHELL
RWCGPVQMTQLRYASEDVEIAGTPIRKGDAVQLILVSANFDPRHYTAPERLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFGKLFTHYPELSLAVAPDELERTPVPGSWRLDSLPVRLG
>CYP107Z8 Streptomyces platensis strain Tu-3077
MSALSSSPFAAHVGKHPGEPNVMDPALIADPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFLND
PTAPSLGRSFDDSPTARLLEMMGLPEHFRPYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLT
RLPEYAEDGVVDLIKHFAYPLPIAVICELVGIAEADRPQWRKWGADLVSLQPDRLSTSFPAMIEHIHELIRERRGA
LTDDLLSELIRAHDDDGGRLSDVEMVTMILTVVLAGHETTAHLIGNGTAALLTHPDQLRLLRDDPALFPRAVHELL
RWCGPVHMTQMRFASEDVDIAGTKIRKGDAVQLILVSANFDPRHYTDPERLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFEKLFAHYPEVSLGVAPEQLERTPLPGSWRLDSLPLRLR
>CYP107Z9 Streptomyces tubercidicus strain NRAA-7027
MSALSNSPLAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN
PAAPSLGRSIDESPAVRLLEMLGLPDHFRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQITDDLLT
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIAEADRPQWRKWGADLVSLEPGRLSTAFPAMVEHIHELIRERRGA
LTDDLLSELIRTHDDDGGRLSDIEMVTMILTIVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRFASEDVEVAGTPIHKGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFSRLFTHYPELSLGVAADQLARTQVPGSWRLDTLPLRLG
>CYP107Z10 Streptomyces tubercidicus strain I-1529
MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN
PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA
RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG
>CYP107Z10 Streptomyces platensis strain I-1548
MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN
PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA
RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG
>CYP107Z11 Streptomyces platensis strain NRAA-7479
MSALPTSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFVDDSPVWLVTRFEEVRQVLRDQRFVNN
PAAPSLGHAAEDNPLTRLMDMLGLPEHLRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA
RLPEHAEDGVVDLIRHFAYPLPITVICELVGIPEADRPQWRTWGADLVSMEPDRLTASFPPMIEHIHRMVRERRGA
LTGDLLSELIRAHDDDGGRLSDVEMVTLILTLVLAGHETTAHLISNGTAALLTHPDQLRLLQDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTTIHRGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMALGVAPERLERTPLPGNWRLNALPVRLG
>CYP107Z12 Streptomyces tubercidicus strain R-922
MSELMNSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN
PASPSLNYAPEDNPLTRLMEMLGLPEHLRVYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRTWGADLISMDPDRLGASFPAMIEHIHQMVRERREA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLVKDDPALLPRAVHELM
RWCGPVHMTQLRYATADVDLAGTPIRQGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLTHYPDISLGIAPEHLERTPLPGNWRLNSLPVRLG
>CYP107AA1 Mycobacterium smegmatis
MTPYSRRDRNH
MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT
DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF
TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL
GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD
DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN
PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG
ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM
EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS
TMREWSGSLPSSGEADSSFAH
>CYP107AB1P Mycobacterium smegmatis
MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD
PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF
TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL
LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG
EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID
NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA
NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR
MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP
>CYP107AC1 Streptomyces atroolivaceus
MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE
GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK
AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR
GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD
DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL
LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE
KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP
QRLPIAW
>CYP107AD1 Streptomyces hygroscopicus
MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI
TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT
RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL
GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS
DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL
AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER
LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN
PFIRSLTALPVEFEAQQPVAG
>CYP107AE1 Streptomyces sp.
VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF
RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG
GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA
LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD
RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL
SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS
PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG
HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH
PK*
>CYP107AF1 Streptomyces collinus DSM2012
MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN
GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH
VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME
ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA
KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP
EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA
AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR
LAADPDELSWRSSLMMRGLEELPVFTA
>CYP107AG1 Streptomyces atroolivaceus
MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP
FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT
LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP
EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA
RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA
VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV
IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA
PRVMHVEW
>CYP107AH1 Streptomyces peucetius
VTTTQDPVTAAERCTADFRRNPHPVYASLRDTAPVCPMKPPHGVETYLITRYEDARAALS
DPRLSKDMYGAMDAYRRIFGDSSVSLDDNMLNADAPKHTRLRRLVNSEFTPRRVEALRPK
IQDIVDQLLDACPTGEPVDLLPAFAFPLPITVICELLGVPAEERPHMQRLSTTVAQTGFS
KESKQAQQKAEEDLHSYFTQLIARKRERPGEDLLSALTEARDKDGGLSENELVSTAFLLM
FAGHKTTAYLIGNAVHHLMANPAQLRAVRENPELVGPAVEELVRYDGSVESATFRFATED
VEIGGTRIPKGALVQISLLSANRDPRKFESPDEFDVRRPGNAQSGHLGFGHGSHYCLGAP
LARLEMQLALTTLFGRFPAIAPADPSAEAKWMEVPFPAFRGLAELPVVLCPES*
>CYP107AJ1 Streptomyces peucetius
MVNTGGEMPLATERLGDSFFQDPQGLFARLRSSAPVTPVITPEGTRVWLVTRYEDVRAAL
ADPRLAKDWVTHMTPDDFDINVDPVQAYLDQHMLNLDPPDHTRLRRLVVKAFTPRRVAAL
RPRISAVNGELLDAMADGPAETDLIEAFAFPLSVTVICELIGIPVGDRESFREWSGTLLS
SRGTREESRAAAVDMYEYFTRMVAERRRSPADDLLSALIAARDSGDSLSEHELLSMVFLL
LVAGHETMVNLIASGVLALLTHPAELGRLRDDPSLLPSAVEELLRYANPLNHATERFTLE
PVTIGDAIIPAKEWVMLATSSANRDASRFAD
ARPAGRGPGRVGPRRVRARDPLLSRRATG
AAGGRDRVRDAAVPVPGADAGGARVVAEVAALQPHPRAGGPPRPTALTRAGETCPARPDE
LGSTVDVADPKGRRPALPADG*
>CYP107AK1 Streptomyces scabies SCAB79691
MVLGAEFVRN PHEVNARLRE QGAVHEVVMP TGLKVWWVTR
WEEGRALLAD ARLSKNVADA
GKLFERHQSD MSRQRDYSHV INRSMVNMDP PDHTRLRGLV
AKAFTMRQVT GLRPWIEKIA
DEVLGSLEGR VEFDVIADFA VPMVRTVISE FLGVPVADRA
EFCAHAAVLT SDGDRESAAE
ASNALAELVS RIVTAKRADL GEDLLSSLIL AADGSDRLSD
DEIISFTVLL FVGGFDTTVN
LLGNGMLALL RNPDQLAAVR DDPALLAGAV EEFLRYDGSA
NISHWRRTVE PVTVGEVTIP
AGEFVFIALG SANRDPARFP EPDRLDVTRS AQGHLAFGHG
IHHCIGAPLA RAEGEIAFRR
LLARFPSLEL TVDPEELEWR PSMLHHGLRS LPVRTAQR
>CYP107AL1 Streptomyces scabies SCAB63301
MDTASASPAG NGTDTETAYE YPFHRPSAVE VPPVYEELRA
KCPVAKVRLP SGDEGYVVSR
YDDARVVLAD PRFSRAAMLD EGAPRLTAAP PMPGSLFTMD
APEHTRVRRL VSREFTARRV
QNLRPRIQQM TDELLDDMEK LSPPVDLNPA FAFPLPVMVI
CELLGVPFED RDRFRGWSDA
FVSLTAHTAE EVMEQRMSMV QYLAQLVQRK REEPADDLMS
ALVAVHDEDG DRLSEHELIT
MGITLLVAGH ETTVSMIGKC VLTLLRHPEH LAALRERPET
IDQVVEELLR INPIGDGGPF
RVTLEDVEIA GTTIPKGSGV IAAVASANQD PERFGADSGV
FDPARSSAGA HLALGHGAHF
CLGAALARAE LQIAVSSLIR RFPRLALADE VGNLSLTSGM
MVHALSRMPV TW
>CYP107AM1 Streptomyces scabies SCAB44031
MSQVETSGGT ASGSGTASGS GSGTSGGDRT RTGAPPDDEV
IRLPMTGEGP LDPPAAWERL
RERCPVATVE LPSGDRAKFV SRYDDVRALL SDPRFARPRA
GDDSARLSAD GSGGVATDAS
AAYPLAIPEA GEPHLRWRRQ VGRYFTAKRM AALRPGMTRI
AGSLLDDMIE RGQPADLKAA
LGFPLPVYVI CELLGAPAED RDLFSHWSDA FLNVSRFSKE
ETRTAFTEFT RYMADLVAAK
RSEPGEDLLS MLVVDSTALP EAERLTDAEL LATGMGLLVA
GHETTANMIG KMAALLLADR
RRWEQLLADP SLVRTAVEEV LRFDANLSAF GMRRQLSEDV
ALGREVLPGG TTVFCGMSSA
NRDDRVFSSP AEMDLTRSPN PHLTFGAGPH SCLGQALART
ELQVALEVLL HRLPTLELAV
PPAELRRLEG LLVGGLREVP VRW
>CYP107AN1 Bradyrhizobium japonicum USDA 110
1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL
SPDFIRNPYP HYDRLRAIDP
61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS
MSHWMLQADP
121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV
DEAIDAVIDR GHMDLIEDFA FRLPVTIICD
181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP
EEIAKGNAGN MMAQMYFQQL FELRRRNPAD
241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG
AGHETTVNLI GNGLLALHRN PDQLALLKAR
301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID
DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR
361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR
IEAEIAIATL LRRLPDLRID DVENPEWRPT
421 FVLRGLKSLP ASW
>CYP107AP1 Streptomyces rochei plasmid pSLA2-L
MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL
VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG
RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL
GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL
VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL
GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF
RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF
MRGPVELPVSWG
>CYP107AQ1 Saccharopolyspora erythraea NRRL23338
MFDTADPAFVADPYPCFAELRRRGEVHRHPGLGMAVAVSHAAASEVLRHRGLGRIWVDAQ
PAADFPAFNLLHRTSLLETEGAEHTRLRRSISAAFARGHVERVRPWVAGLADALVGGLVE
RGGGDVVEEVAAPLPVQVIAELLGVPESDRNLLRPWSNAIVKMYEPGLPERRRAAAESAA
AEFAEYMRALADRRRSAPADDMVSDLVAAEELSADEVVGTAVLLLMAGHEASVNLVANGV
LALLRHPGQWRRLVDDPGLVPTAVEELIRYDSPLQLFERTAVEDVVVAGHRVAAGSKIAA
LLGAAARDPEVFESPDVLDVGRQPNPHLGFGAGIHYCLGAPLARVEAAAALSALVRLAPR
LEQAGEPVRRPEFVIRGLRELPVSV
>CYP107AR1 Saccharopolyspora erythraea NRRL23338
VQPDQSPTPRPESRHSPAAACPHAAVHREERPGGLVTWQISAFSEARAALGDSRFSKDPR
RLGEALRAGGRSMFAEYGDNLLDNLLNSDPPDHTRLRRLVGKAFSPATIERLGPTTQRLA
DELVASMLPAGRADLLAQFAYPFAFGVIARVLGLPPDSYRIFQRWTESMTAPREQGTDRM
VAARHLCEHVTELVRRSREWLASAPAETLLDELVSARDDGDRLSENELVATVLLLIIAGH
ETTVNLIGNGVHALLQHPGQLALLRDHPDLIDGAVEELLRFQPPISKTTLRVTTTDVEVA
GTEIPAGSIVNVLVPAANRDQRQFPDADRLDITRPPSAHMSFGHGIHYCIGAPLARMEGR
IAIGALLRGLPGLRLAEPAAEIPWRASNILRGLQRLPVRFDSAGADDEVRDRRHAGAARV
HA
>CYP107AS1 Saccharopolyspora erythraea NRRL23338
MTESIQRDADSQEAACPHARAYPFGDPGALDLDPDYARVRDEEPLTRIRMPYGEQGWLVT
RYDDVRTVLADPRFSRSEVLKRDVPRPTPQQVERPGTLVTTDPPEHGRLRRLVAGAFTHR
RAESMRPRIRGVVDELVDEMLAGDKPADLVAAVSMPLPVNVICELLGVPREDRHVFHSGA
VLSDYTVPADEREATFKSLADYLAVLIAERRARPEGPGDDVLGALISARDTDGDRLSEDE
LIELWVDILVAGYASIMSVTPDMVVTLLTERDRWDGLVADPGGVPDAVEEMLRVMPTIIE
SGHSRVATEDVEIAGGTVRAGEAVLPCLPAANRDPAVFDAAEEMRLDRDAGKHIAFGFGP
HYCLGASLARVQLQSVLTALVRKVPTLDLVEAVREDSTRVAAAVQGQLLVTW
>CYP107AT1 Saccharopolyspora erythraea NRRL23338
MSVGDIDTPSGEFDFAANLLPFDPLDPAFQADPYPFFRLVRETAPALCTQPGMWVVTGFR
ECSAVLRNPKFGHGDGRLVASQITHDAEGNVVRPFVFMDPPDHTRIRSLVTKAFSARMVE
RLRPTAERLVGELLAAAMSGPADEPVDLMAELAFALPSNLISELLGMPPQDKPLFEQWSS
ALGRGLDPDFMLSPEEMQRRDQARTEFDGYFAELARRRRAEPADDLVSALVAVEEDGRNL
SMSELVSTCRLLLSAGYLSTAHLIGNGVNALLRHPEQFEWFRAHPDQVAGVVEELLRYDS
PVQTAGMRTALQDTEIGDQPVSAGEGAMLLVGAANRDPAAFPDPDRLDVSRKPERNLGFG
IGAHFCVGAPLARLTTQVALTALAGLRVELATDDAPRINNLVLRGFAELPVFLRAA
>CYP107AT2 Saccharopolyspora erythraea NRRL23338
MSTTEGAPPVDSNVVRQLLLFDPFDPEFRADPHRVYREIRESGPVTATPGGLWLVSGHRQ
VSAVLRDQAFGWGEAELAAGHFTTDDEGNTVRPLTFADPPEHTRIRSLVTSAFSARIVER
LRPRAQELARESLAAALAGGGSADVIQQVAYPLTGRLLCELLGVDPEYQERFRAWAEAMG
RGLDPDFMQSPDQLARREEARAHFHEYFAELAARRRAEPGDDLVSALVAVEQEGDRLTAT
ELVVTCTLLLSAGYATTVHLIGNGMLALLENPDQLAWLRANPGRVGDAVEEVLRFDGPIQ
LVSRVALRDTEVDGHAVAAGSPVLLLLAAANRDPAVFDDPDRLDVSRKPGRNLGFGVGIH
FCLGAPLARLTAQAALSLLVEHELVLDGPRPAPTGSLVLRGLAELPLRSA
>CYP107AU1 Saccharopolyspora erythraea NRRL23338
MTAGTNNAGRLGALAEAVLGYNPVDPEYHANAHEHHRRMAERGPIFRTPGGMWTAVSHAA
CSAVLRDDRFGHDPGSAAQNLFDSTQRPSVAQRSFEFMDGPDHSRLRRLVNRAFTARRVE
RLRPAVRTLADQLLTDVSGRIDVLADFILPLAMTTIVDMLGAPTEDNHLFRAWAEPIVRG
LDPDFLLSSSELAAREQANAEFAEYFDRLVALRRAEPKDDLISALIAVEDDGVVLSGNEL
ISMCLLLLAAGHESIMHLVGNGTVALLRDEDQLEHFRGHPGEVTNAVNELLRYDPPVVLL
VRTALADAEVLGNRVRRGEIVWLQIGAANRDPAVFPDPDRLDLTRDTGGSLAFGLGIHFC
IGASLARLEAAAALSALLHRDVALASEQLVHQKNVVIRGYEEVPVVLR
>CYP107AV1 Saccharopolyspora erythraea NRRL23338
MTTAEPAETGSLAELNLGMRLVLHGAVTWSIARLGDPVARLLHSPWRRDPYPIYRQLRAR
GPLVRSRLGVWAASTYEVCDAVLRDRRFGVRTSDGSYGDPTAAAVGLQLSLLELDPPDHT
RLRKLAAPAFRPRKLENYRQRIEDTAHELLDRALAKGEFDLIRDFATPLPIRVICELLGL
PELGAERLAVHGAALSGALDGIRSIRHLRRMRASTLELNELFGDLIEQRRRQPGEDIVSD
LVTALDQDRLDSTELVQMCDLLLVAGFETTVNLIGNGVLALLERPDQWRLLCDDPDQAVG
VVEETLRWDPPVQTTMRVAHEPVEVAGRLLPRNSAVLPMLGAAGRDPAVHFAPDRFDITR
GTRGDHLAFSSGIHYCLGAPLARLESEIAFRCLATRVPELRRSGALVRRPTSVIHGLSAL
PVAASKATAGGRR
>CYP107AW1 Salinispora
tropica (marine actinomycete)
MESVTSTSAPPPVPYIADPYPALARIRANGPVSILHSDEGIPMWVIARYRNVRAALADPR
FGQDARRAQTLADNRVAGVTLGGDVIHMLNSDPPDHTRLRHLVQGAFTARRVAAMRPLVE
RITTSLLDGVGGRQTVDLVQDFAFPLPMLVICELLGFPAEERDAYRSWSTAILTHNDDPA
AFATALRDMTDYIEVQLRHRRARPGEDLLTELLAARDAGQLTDDEIVGMVFLLLIGGHET
TVNLLGTATLALVRNPDQHRWLLANPHALSEAIDEFLRYESPVAMATLRFTTAPVTVDDV
VIPAGELVLVSLGGANRDPDRFPDADRLILDRRDTGHLAFGHGLHRCLGAFLGKLEGEVA
LGALLGRYPGLTLAAEVRQLRWRDTIMLRGLESLPVSLHG
>CYP107AX1 Salinispora
tropica (marine actinomycete)
MTSRPTAVFDQCLLRDPHSRYNALRDQAPVHHVLTPDGAPAWLVTRYNDVRAAFTDPRLS
VDKRFSGTDGEHGSSLPPELDAHLLNRDPPDHTRLRRLAAAACTPRRVADLHPAVERIVS
TLLDGLAGHDRAELIGSLASPLPLQVMHELLGLPTQANIDFRTWTNTLLSADANQPAQSR
AAMANMRRFLIEQLAHKRAQPGDDLLTGLLAAREDDDRLTDDELVAMVFLLMFAGYDNTA
ALIGTVTHALLTNAELHEAVRGGSLALDELIDEVLRWNPAFPLAVRRFAREPITIAGQTI
PAGDRIWLCLASANRDPAQFTQPDELGIIGLRRSHLSFGHGIHYCLGAPLARLQTTIAVT
SLLNRFPEMRLAVPAHDIRWRESFRLRGLIALPVYL
>CYP107AY1 Salinispora
tropica (marine actinomycete)
MSQDPTMRAELAPIPRSGARLGQEYDQLRNAGDVHQVLLPDSSLAWLVTNPKLVSRALTD
PRLALNRRHSRGSWSGFALPPALDANLLNLDAPDHTRLRRLVGPAFSPQRVSALRPRIRR
TAEHLLDTLVATSGPVDLVTGYCTPLSVQVIADLMGVPEAGRADLRTWTDTMLTSYPPDR
DAIRQAVVELHGYVVDLIDTKRQQPGDDLLSALVTIEQDGDRLTRDELTSLAFLILFAGY
ENTANLIASTVLRLLDHGGLRGVQLPEAIEETLRLEPPAPAAVRRFPTEEMTIGGATIPA
GDIVLLSIAAATRGTAGNAARLAFGNGPHFCLGAALARVEAEEALTVLARRLPDLALALP
VAQVRWRPTFRTHGPAELLVTW
>CYP107AZ1 Roseiflexus sp. RS-1, complete genome.
MHHPTEPPPELWSAAAISDPYPIYDRLRAEQPIRWTGGDWQIFR
YADAQALLRDPRLGADRLQVDPQWLIASGLEPLFKTRDSMMLFADPPDHTRLRTLVHR
AFTPRVVESYRPLVQRIVDQLLDAAAARGAIELIGEFAYPLPVTVIAHMLGVPVNMHD
QFRRWSDSLAAFIGGTTRPEADVLPAALKAVLEMTDFFLALVAERRRAPRDDLLSALA
QAEDGGDRLSEQELVANSILLLLAGHETTTNLIGNGMLALMRHPDQFALLRDHPELTP
SAIEELLRYDSPVQVTSRRALTDIEFQGHRIEEGQAVTVFIGAANRDPAQYQDPARLD
VTRGDVRHLSFGHGPHYCLGAPLARLEGQVAISALVRRFPHMRTLDEQVVWRDNFALR
GLQSLHIELE
>CYP107BA1 Roseiflexus sp. RS-1, complete genome.
4472327
MTPTIVARLASPEFLADPYPVYRQLIEQTPVFWLPHANAPGGMWCIARYDDIAFVLREAPIFKDT 4472133
4472132
SRIAPPDTLTPLDRAMLQRDPPDHTRLRRLASHAFTPRRVHDLMPRIEQI 4471983
4471982
SLDLIERIGARGEADFIADYA 4471920
4471920 PLPIIVIAELLGVPFEDHEQFSTWSDQIMAGSDSVLGGEEAARQSHQAMASLVDYFTTLI
4471741
4471740 RQRRHSPRDDLISALIAAHDAGDSLSEDELLGMCVLLLIAGHETTVNLIGNGLLTLLRH
4471564
4471563 PDQLNLLRRQSEYLTSAIEEMLRYESPVQRSTPRFAAEPFVIGGEQIEAGQQISLMFGAA
4471384
4471383 NRDPAHFSDPDRFDITRQPNPHLGFGMGIHYCLGAPLARIEARVAFTHILERLPAIRLAT
4471204
4471203 DTPAWKPVTWLRGLKSLPVLV*
4471138
>CYP107BB1 PlaO2 [Streptomyces sp. Tu6071].
ABB69746
1 MDRVLDFLSS ADSAGELQPR LVELSRQETL PRVLLADGQE AWLVTRNEDV RTVLSDRSFT
61 RDVMGERARQ AGETPDGARS VNMDGRPHNE LRALVSKAFT VRRIEAMRPR
IQAWTDELID
121 AMEETGPPAD LVAHLAVPLP ALAICELLGF
PVEDRQVLSG WCERITRLGE GGPDQRAWQE
181 LSAYIARRVP VERAAARGGL APETSILTRL
VHAHDSEDAL SMEELLSLTV VVLAGGLETT
241 QTAIGAGMVR LFRNPAQLDK VRADPDLVVP
AVEEILRYQP VIDVNRVQVA TRTVRLGGQE
301 IRAGDLVQVS VNAANRDETV FPDSERCDVT
RGPNPHLAFG YGAHHCLGAA LARLELKTAF
361 STLLRRLPDL RPAVPLESLG WRGGHVTLGL EELPVAW
>CYP107BC1 PlaO5 [Streptomyces sp. Tu6071].
ABB69764
1 MTESLETTSP DPTRSGNSDT GATPGYTVPK QVNDMWREKP VRRFSMRDGR EAWLVTGRAE
61 VRTVLADPRF SRVEARRLDA VMSPAVIFTR PGILDMDPPE HTRLRRLVAG
EFSARRMRAL
121 RPRIQQIADE LIGTMKAAGP PADLAEGLSY
PLPIAVICEI LGVPYADRER FRAWADRVSA
181 PGTQPQEAMA ALRSLFDYMG GLVDDKHAHP
DGSLLHGLVT ARDEQGRLDN EELVTLGCGL
241 LLAGYETTAT MLGKGLLALL DNPDQLAVVR
SDPRAVPAAV SEVLRHVTPG VDPHTGLIRA
301 TTADVELGGT VIPAHSVVVA CNTAANFDPA TFRDPDRFDV
TRENAAAHLT FGHGMHRCVG
361 AQLAQIELEA AFAALFPAIP GLRLAVPADE
ITYTQSTLIR GLRSLPVLW
>CYP107 fragment Streptomyces noursei
WTTPTRWSCSAPSLICLPRHGRNTAHRRTSRSHHPGRARRHPDR
DTLIPARSTVFIAGAAANRDPQKFPNPDTFDITRNTQGHLAFGYGVHHCIGRPLAQME
GEVAITALLRRFPHLHLTTPSQNLTWRRSFLRGLTALPVTLN
>CYP108A1 Pseudomonas spp.
MDARATIPEHIARTVILPQGYADDEVIYPAFKWLRDEQPLAMAH
IEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSL
TSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALY
YPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIAT
FYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS
GGAIIGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKR
GDRIMLSYPSANRDEEVFSNPDEFDITRFPNRHLGFGWGAHMCLGQHLAKLEMKIFFE
ELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFTKA
>CYP108B1 Mycobacterium smegmatis
MFLTPVKFSPSEVPD
MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW
AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH
MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV
QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL
NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV
IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA
PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR
DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT
TFVGGLKHLPIRYSVR
>CYP108B2 Mycobacterium smegmatis
MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW
AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH
MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV
TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ
MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV
IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST
PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR
DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT
TFVGGLKHLPIRYSIR
>CYP108B3 Mycobacterium smegmatis
MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW
AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ
HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV
NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL
EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA
GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF
MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH
VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG
LKHLPVRYALR
>CYP108B4 Mycobacterium marinum MM3999
MSAPTMDEAA
LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI
ERDNTLFTNW
PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK
VRVDELAKNY
VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS
DDSEFKRGST
SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV
SYYLIVATAG
HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM
RTASRDTVVR
GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM
GAALARMEVG
SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *
>CYP108B4 Mycobacterium ulcerans
MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI
ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK
VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS
DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV
SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM
RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM
GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM
>CYP108B5 Mycobacterium avium subsp. paratuberculosis K-10.
MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW
VEVPNYKPFW AITKHADVMD
IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ
HRVVRAIGSD WFRPKAMRAL
KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL
LGLPEADFPR MLKLTQELFG
SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED
LASAIANARV DGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL
DLMPLATEEM IRWVTPVKEF
MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR
FDVGRDPNKH LAFGYGVHFC
MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG
LKHLPVRYSL A
>CYP108B6 Mycobacterium flavescens PYR-GCK
MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW
VDVEGYNPFW AITKHADIMA
IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ
HRKVRAIGAD WFRPKAMRAL
KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL
LGIPESDFGR MLTYTQELFG
SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED
LASAIANARI NGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP
ELLPLAVEEM IRWVTPVKEF
MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR
FDIGRDPNKH VAFGYGVHFC
LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG
LKHLPIRYSL TR
>CYP108B7 Mycobacterium vanbaalenii PYR-1
MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN
SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG
ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT
AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP
GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH
VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR
>CYP108B8 Mycobacterium vanbaalenii PYR-1
MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND
LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY
VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD
FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG
ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF
DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR
>CYP108B9 Mycobacterium vanbaalenii PYR-1
MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE
LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY
VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD
FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD
QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF
DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR
>CYP108C1 Saccharopolyspora spinosa strain NRRL 18395
VNIKLMGAGRTLADPAAYANDDRIHKALALLRREAPVHWVEAPGYRPFWAITRHADVMEIERQPDLFRNAPRPILV
PDAMEKRTAAQGTNFRTLVSMDGAEHRQVRAIGTDWFGPGALRHLETRVTELARQYVDRMLEFDGECDFVTDIAVH
YPLDVILSLLGLPRSDFPRVLSLAKELLGNADQEINGGRGAEGFVAVQQELLTYFNELTAARRATPTTDLASAIAN
ARLDGALLSEFDAASYYILIATAGHDTTSASIAGGLQALIENPQQLRQLQDDLTLLPTAVDEMIRWVTPIKCFLRT
ATEDYVLRGTTIRKGDSVLLSYPSANRDEDLFEEPFRFDIRRTPNRHLAFGFGVHYCLGAALAKMEARAFFAELLP
RLDSVQLAGKAELFATNFIGGLKHLPIRYKLRPSV
>CYP108D1 Novosphingobium aromaticivorans
MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY
GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST
VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK
IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE
DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP
MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR
WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH
LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW
KAA
>CYP108E1 Ralstonia metallidurans
MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH
PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD
DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI
VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER
RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP
GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA
SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV
VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA
>CYP108F1X = 108B4 Mycobacterium marinum MM3999
MSAPTMDEAA
LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI
ERDNTLFTNW
PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK
VRVDELAKNY
VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS
DDSEFKRGST
SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV
SYYLIVATAG
HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM
RTASRDTVVR
GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM
GAALARMEVG
SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *
>CYP108F1X = 108B4 Mycobacterium ulcerans
MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI
ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK
VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS
DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV
SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM
RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM
GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM
>CYP108G1 Caulobacter crescentus CB15
1 MTISTDIANT IIDPKAYADG DRIDQAFAHL RREAPLAVAQ
PDGFDPFWVV TRHADILEVE
61 RQNELFHNGD RATVVTTIEP DKKVREMMGG SPHLVRSLVQ MDNPDHFAYR
KITQGALLPQ
121 NLRALEARIR EIARGFVDRM AEHGDRCDFA
RDVAFLYPLH VIMEVLGVPE SDEPRMLKLT
181 QELFGNADPD LNRTGKSVTD VGEGVDSIQS
VVMDFMMYFN AITEDRRANP RDDLATLIAN
241 GKINGEPMGH LEAMSYYIIA ATAGHDTTSS
TTAGALWALA ENPDQFAKVK ADPSLIPGLI
301 EESIRWVTPV KHFMRTATAD AELGGQKIAK
GDWIMLSYPS GNRDEAVFED PFTFRVDRTP
361 NKHVAFGYGA HICLGQHLAR MEMRVLWEEL FARLDHVELD
GAPTRMVANF VCGPKSVPIR
421 FKMH
>CYP108G2 Ectocarpus bacterium, 67% to CYP108G1 Caulobacter crescentus
AE005918
159023
MIDPNIPDDIAITVVDPRSYADGNAIDEAFAKLRKDTPLGVAGPQGFEPFWVVTKHKD
IVEVERNNEVFHNGDKSTTLVDANTDTA
158766
158765 VREMMGGSPHLIRSLVQMDNPDHKNYRGITAANFMPQELKALEVQVRKIAKSFVDHMEEL
158586
158585
GRKNDGRCDFAKDVAFLYPLHVIMELLGVPQSDEPKMLKLTQELFGAADPELNRTGKE 158412
158411
RDDPKEALAALSGTVAEFVEYFTAVTEDRRKTPRADIASVIANGKVNGEAIGIFEAMGYY 158232
158231
IIVATAGHDTTSGTTAGTMWELAKDRQKFLQVKNDPKLIPLLVEESIRWVTPVKHFMRSA 158052
158051
TQDTVLGGQEIKKGDWMMLCYQSGNRDEDVFDDPFEFKVNRQPNRHIAFGHGAHVCLGQH 157872
157871
LARMEMRALWEELLPRLDSVELDGEPTRMLANFVCGPKSVPIKFKMS* 157728
>CYP108G3 ABS63163.1 Parvibaculum
lavamentivorans DS-1
CDS complement(1684831..1686087)
locus_tag="Plav_1544"
56% to CYP108G1 Caulobacter crescentus
MTDKTIDNAIVNPKTYAHVDEFHRLFTQLRKEEPVRWTEPDGFRPFWTVSKHADIMEVERQNDKFLNDPR
LTLQTIEVEEEVKKFTGGNSKLIRSLVDMDNPDHRNYRGLTQAWFMPPNLKAISARVEALAEKYIDRLEA
KGGECDFVSDVAVWYPLRVIMTVLGVPAEDEPIMLKLTQELFGSTDPDMKRPDATETVNTVTEFFNYFTA
MTEDRRKNPKDDVASVIANATIDGEPIGHLEAISYYIIVATAGHDTTSSTAAGGLLALMQNPEEFAKLKA
NPEGLLGGAIDEMIRWTTPVKHFFRTAAVDYELRGQKIKAGDNLLMCYWSANRDEEAFDDPFSFKIERSP
NKHLAFGYGAHLCLGQHLAKMEIRALYKELLARLDHIELAGDPAWVEASFVSGLKRLPIRYSMKRKAA
>CYP108H1 Ectocarpus bacterium, 49% to CYP108G1 Caulobacter crescentus CB15
AE005918
1535540 MGAASHKAQTSLSELVAPIFNPASFSHRDKIDG
1535639
IFTTLRQDNPLACVEVPGYDPHWMVTKYSDVKEITRQDNLFHSGDRPKILHSQAGEA 1535809
1535810
LARSFTGGSPNLFQSLVQLDPPEHTAYRNVLQGEFMPGGIAKMKENVAKTAQEFVDQMAS 1535989
1535990 LAPTCDFADDVAMNYPLQVVLDIVGVPREHHPKMLQLTQWLFSYADPDLKRPGSDIT
1536160
1536161
DPEEIIKTWNVVFTQFHEFFMPLVEARRANPKEDIASLIANAKINGESMEERKMISYFG 1536337
1536338
ILATAGHDTTSATTALGMKMLAENPDMLARLKEKPDLIPSFVEECIRWGSPVQHFIRSAT 1536517
1536518
EDYVLRGQTIRKGDLLYISYLSANRDEEEFDDPFTFKMDRAPNRHVGFGFGGHVCLGQH 1536694
1536695
LARLEIRTIWQTLLPRLTEVELTGPVKFTESEFVCGPKSVPIRFKMDG* 1536841
>CYP108H2 Marine metagenome 1093018949056, AACY022454370, 57% to CYP108H1
APPRRGPQQSAEHTETWNRVYKEFEEYYEPVIKDRQTCPREDLASLISNGKIDGCPMEHR
AQISYFIIASTAGHDTTSATLATAISVLAERPEVLEQLKANLELIPAFIEETIRWASPVK
HFLRHATQDYELRGQQIKKGDLMYLSYISGNRDEDLIEDPFEFRIDRKPNRHVAFAFGNH
ICLGQHLARLELKIMLEELLPRLESLQLTGKPKLAISDLVCGPKSVPIQYDFKRTA*
>CYP108-un1 Mycobacterium smegmatis
LTDHYAMAHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAET
SLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGGGLH
SCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISLPVA
FTPERSQT
>CYP109A1 Bacillus subtilis
MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESP
VRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAF
TPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLI
KTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQ
AEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVAN
VIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKI
DRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFV
FGVKRLPVRITFK
>CYP109B1 Bacillus subtilis
MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE
NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP
RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA
WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE
ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV
EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR
HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF
RVKM
>CYP109C1 Sorangium cellulosum So Ce56 (myxobacterium)
sce_040811_111
MNLFPDEMRR DPYPLYDQLR TGSPVFHVAP LDLWMVFDYD GVKRALTDHE AFSSAVAPPT GKAPDWIVFS DPPRHTKLRS IVLRAFTPRS IAGLEPRIRE LSRDLLDPWI ERGEMDLAAD YAGPLPTMVI AEMLGVPPED RARLLRFSEV IVNLSHAISG GEEAARAVSE HAVVKEEMKV YLAGLIEARR RAPAEDLLTR LVEAEVDGER LTEGDILNFF QFLLAAGTET ATNLIDNAIL CFLESPAELF RLRAAPELLP SAIEEVLRHR SPLQMVFRET RRAVEVHGQV IPAGKLVLPV IGSANRDPHQ FHDPGRFDIG RDPNPHVAFG HGIHFCIGAA LARLEARIAL PDLLCRLKGL RRASDEPWEP RKAIIVHGPA RLPIRFEPGR RAAVHAAGAH TPCPG
>CYP109C2 Sorangium cellulosum So Ce56 (myxobacterium)
sce_040811_8140
MNLFSEEMRR NPYPAYDQLR SRTPVLHYPP SDSWLIFDHD GVKRALHDHD AFSSVVSPPG TRTAEWLIFS DPPRHTKLRA LITRAFTPRA VAGLEPRIRR LSRELLDRTI ESGQMDVAED YAVPLPLLVI AEMLGAPAAD QPHFKRWSDA ILDLSHTVSG SEEAARALDA FTAVTAEMQA YLRGLVEQRR AAPEDDLLTR LVEAEVDGER LNEDEILGFF QLLLVAGHET TTNLIGNAML CFLENPDELA RLRAAPELLP SAIEEVLRYR SPVQAMFRVT RRDVPMHGQV IPAGKAVLAM IGSANRDSQQ FRDPDRFDIA RDPNPHIAFG HGIHFCIGAP LSRLEARVAL ADLVARLGGL ERASDAPWEP RRAIHVHGPA RLPIRFAPGP RLGGAPG
>CYP109D1 Sorangium cellulosum So Ce56 (myxobacterium)
sce_040811_4257
METETAPSPS PEQIDLSAPS VIADPYPAYR ALRGRSPVLY ARVPAGGAAG LGEPIRAYAL LRHAEVLAAL RDPQTFSSNV TDKIRVLPRI TLLHDDPPRH THLRRLVSRS FTPRRIAELE PWIGRLAASL LEATGDGPSD LMGAYAMPLP MMVIATLLGI PAERYVQFRS WSESVMSYSG IPAEERASRG KAMVDFFAAE LEARRRAPSG DLISALVEAE IDGARLDTPE AVGFCVGLLV AGNDTTTNLI GNMAHLLSER PELYRRAQQD RSLVGPIIEE TLRHSSPVQR LLRVTTRPVD VSGVMIPAGH LVDVVFGAAN RDPAVFEEPD AFRLDRPPAE HLAFGQGTHF CIGAALARME ARIALNALLD CYESITPGEA PPLRQTRAIM PLGFESLPLV LRRSRATA
>CYP110A1 Nostoc sp. PCC 7120 same as Anabaena sp. PCC
1 MLTQLPNPIS VPSWWQLINW IADPIGFQKK YSKKYGNIFS MQLAGIGSFV ILGEPQALQE
61 IFTQDSRFDV GRGNTLAEPL IGRTSLMLMD GDRHRRERKL LMPPFHGERL
QAYAQQICLI
121 TNQIASEWQI GQPFVARSAM QKLSLEVIIQ
IVFGLADGER YQQIKPLFTD WLNMTDSPLR
181 SSMLFLKSLQ KDWGTWTPWG QMKHKQRSIY
DLLQAEIEEK RTKENEQRGD VLSLMMAARD
241 ENGQAMTDEE LKDELLTILF AGHETTATTI
AWAFYQILKN VNVQEKLQQE LDRLGANPNP
301 MEIAQLPYLT AVSQETLRMY PVLPTLFPRI
TKSSINIAGY QLEPDTTLMA SIYLIHYRED
361 LYPNPQQFRP ERFIERQYSP SEYIPFGGGS RRCLGYALAL
LEIKLVIATV LSNYQLALAE
421 DKPVNVQRRG FTLAPDGGVR VIMTGKKSLK FEQSSKIFN
>CYP110A2 Anabaena variabilis (a cyanobacterium)
MLTQLPNPISVPSWWQLINWIADPIGFQKKYSQKYGDIFSMQLA
GIGSFVILGEPQAIQEIFTQDSRFDIGRGNKLAEPLIGRTSLMLMDGDRHRRERKLLM
PPFHGEKLQAYAQQICLITHQIASQWQIGQPFVARSAMQKLSLEVIIQIVFGLANGER
YQQIKPLFTDWLNMTDSPLRSSMLFLKSLQQDWGNRSPWGQMKYQQRCIYDLLQAEIE
EKRTKENERRGDVLSLMMAARDENGQAMTDEELKDELLTILFAGHETTATTIAWAFYQ
IFRNVNVREKLQQELDSLGENPNPMEIAQLPYLTAVCQETLRMYPVLPTLFPRITKSS
INIAGYQLEPNTTLMASIYLIHYREDLYPHPQQFRPERFIERQYSPSEYIPFGGGSRR
CLGYALALLEIKLVIATVLSNYQLALAEDKPIKVQRRGFTLAPEGGVRMIMTGKKSLR
FEQSNKIFN
>CYP110B1 Nostoc sp. PCC 7120 Same as Anabaena
1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK
LAKDVPAIVF LSNPKDIQQI
61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER
MRGYSQVITD
121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM
QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF
181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA
DELIYQEIQE RRENPDPSRT DILSLLMDAR
241 DADGQPMTDV ELRDELMTLL VAGHETTATA
LAWAMYWIHK LPPVKARLLE ELDSLGDNPD
301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR
RVIETMALGG YELPPGTPVL GSIYLTHHRE
361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG
TRRCLGLAFA QWEMKLALAK ILTSYELELV
421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ
ITSRILETTT VS
>CYP110B2 Nostoc punctiforme
MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK
SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL
LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP
RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI
RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY
WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT
PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR
RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV
KFPILQTATV
>CYP110C1 Nostoc sp. PCC 7120 Same as Anabaena
1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM
FTAEVIGFGD TVVFVSHPQG
61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF
HGERMREYGH
121 LIRNITENLF SQLQQDVTFS ALTAMREISM
QVILQAVFGF YEGERCQQFK HLLPIFLSEL
181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR
QREKIDKLLY AEIAERRQEI NSDRIDILSL
241 LISARDETGD SMSDKELRDE LITLMISGHE
TTGTAMAWSL YWILQTPEVF QRLIQELDSL
301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM
LTLPRVVKEP IELLGNRLET STTVVGCIYL
361 THHREDLYPE SKLFKPERFL KREFSQYEFM
PFGGGVRGCI GQALAMFEMK IVLATVLSRY
421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT
GQHKRQNYSM AASTTFNA
>CYP110C2 Nostoc punctiforme
1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK
IVGFGDTVVF VNHPQAIQEI
61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER
MQAYGQLICN
121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL
QSIFGFYEGE KIQKLRQLLP LLLELFESPL
181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI
DQFLYTEIAE CQQQADPERI DILSLLISCR
241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA
MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD
301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR
VVQEPLELLG HSLEPGTILL PSIYLTHHRE
361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG
VRRCMGEALA LFEIKLALAT IVSHYHLALV
421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR
KESLINMTTT PLS
>CYP110C3 gi|75908202| YP_322498 Anabaena variabilis ATCC 29413
95% to 110C1
MKYQIKRPNPLKTHPFLQKLQWIADPVEYMEKASLQHRDMFTAEVIGFGDTVVFVSHPQGIQTIFANDRK
KLVAVGEANRILYPLVGNNSMFLLEGVKHKQRRQLLMPSFHGERMREYGHLIRNITETLFSQLQQNVTFS
ALTAMREISMQVILQAVFGFYEGERCQQFKHLLPVFLSELFQSPLASSILFFPFLQKDLGNLTPWGRFVR
QREKIDKLLYEEIAERRQEINSDRIDILSLLISSRDETGNSMSDQELRDELITLMISGHETTGTAMAWSL
YWILQTPEVFQRLIQELDSLGDSPDPMSIFRLPYLTAVCNETLRINPVAMLTLPRVVKEPVELLGNRLES
GTTVVGCIYLTHHREDLYPESKLFQPERFLKREFSQYEFMPFGGGVRGCIGQAIAMFEMKIVLATVLSRY
QFALADGKPERPQRQGFTLTPANGVKMLITGKHQRQNYSTAASTTFTT
>CYP110C4 gi|119510163|
ZP_01629302 Nodularia spumigena CCY9414
MSTPNRLKTPAFFQQLQWVADPVGYMEKAAQQYPDIFTAQVVGFGNNLVFVNHPQAMQEILTNDRKKLFA
GGKENKILQPLLGDYSMIMLDGDRHRKRRQLVMPSFHGDRMRSYGEIISNITEEVWSNLPTDKSFLARNV
TQDITLQVMIQAVFGVYQGERSQQLKKQLELMANIFRSPLSSSMLFFSSLQQDLGAWSPWGKFVRDRQEL
DNLIYTEIAERRQQNLENRIDILSLLMSAEDESGNPMTVQELRDELMTLLFAGYETTATALAWGLYFIQK
HPEVQEKLLQELDTLGDSPDPMSIFRLPYLTAVCNETLRIHPVAMLTFPRTVKEPVEISGYALDPGTILV
GSMYLTHQREDLYPEPKQFKPERFLERQFSPYEFIPFGGGVRRCVGEALAVFELKLVLATILSRYELALT
DDQPEVPRRRGVTLAPGRGVNMMITGQRLA
>CYP110C5 gi|67925622| ZP_00518945 Crocosphaera watsonii WH 8501
MKTIPTPKTPTLVQQLQWVLNPTGYLQTNHHRYPDLFKAKIIGLGNDIILISNPEIMQYILTHDRQEFTA
PSSLNTLLKPLLGDYSVVMLDGDGHRQRRQLVMPSFHGERLKVYGDLTCRITREAMEKLPENQPFLAREV
MQDISLKVIMEAVFGVTEGERYEELQYRLKELLDLFDSPITSGFLFFPSLQKDLGNWSPWGYFLRQRQAL
DKLIYAEISDRRANPDPERTDILSLLMFAKDEQGESMKDQELRDELITLLMAGHETTASAMAWALYWLHH
IPEIKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRLAQQTVEVGGYTFKPGDIVA
GCLYLTHLREDIYANPKQFNPQRFLDHKYSAYEFIPFGGGSRRCMGEALAKFEMKLVIAIIISEYCLKLA
DTQPEKQQRRGLTLSPKRGVKMILEGKRQPQKARELELSTR
>CYP110C6 gi|126660859|
ZP_01731952 Cyanothece sp. CCY0110
MKTIPGSKTPKLIQQLQWIFNPTKYLKTNHRRYPDIFKAKIIGFGDKMILTSRPEIMQYILTHDRKQFTS
PSGLNAILRPLLGDSSVLMLDGDRHRQRRQLVMPSFHGERLKVYGDLTCRITEEVMAKVPQNQPFLAREI
MQDISLKVIMEAVFGVTEGKRYEQLQDRLKKMLDLFNSPLTSAFLFFPFLQKDLGSWSPWGHFLRQRQAI
DELIYAEISDRKAHPDSDRTDILSLLMSAKDEQGQGMKDQELRDELMTLLTAGHETTASAMAWALYWIHH
TPEVKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRVAQEKVEVAGYTFEPGDMIM
GCMYLTHLREDLYTNPEQFNPQRFVDRQYTPYEFIPFGGGSRRCVGEALAQFEIKLVIATIMSQYCLKLA
DTQPEKQQRRGVTLSPARGVKMILEGKRQPQPVRELELSRQ
>CYP110C7 gi|119486461|
ZP_01620519 Lyngbya sp. PCC 8106
MKTLNSPKTSPLIQRLQWVFNPLEYMETNVKINRDIFNTQVTGGVGLIFVNSPEGMQELLTRDTKEFYAP
GSINEILKPLLGEQSVMLLDGDRHKRQRKLLMPPFHGERMRTYGELILNITQQATAKLKPGQPFIARNAM
QEITLAVILQAVFGIYEGSRYDKLKQLITSLLAVTDSPVSSSLLFFTSLQKDWGAWSPWGRFLRMRQKVD
QLLFAEIEERRQNWDENRTDILNLMMAARDEDGQPMADEELRDELLTLLVAGHETTATAMAWALYWIHRQ
PEVYQKLIQELESLPENADPMTIFRLPYLTAVCNEALRIYPVAMLTFPRVTKEPTQLLGYELEANIGLAG
CIYLLHHREDLYPEPKQFKPERFLERKFSPYEFLPFGSGARQCIGMALAQFEMKLALAQILLDYDLTLLE
KRPVKAARRGVTLSPVGGIKMMMNGKRTPSKSVAIPATV
>CYP110D1 Nostoc sp. PCC 7120 Same as Anabaena
1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN
FTIWGSGESY FVYFSHPQAL
61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG
ERMRAYGQTI
121 REITQQVTQA WQMGKPFNIR ASMQEITMRV
ILRVVFGVDE GELFQELRQL LTTLLDFMGS
181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK
KIDQLIYALI AQRRAEFGEN RQDILSLLIS
241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI
DSVPEVREKL FQELDTLNDD
301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF
FRRTKNPMEI MGYKLPKATL VVPSIYLAHH
361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG
GGNRRCIGLA FAQYEMKIVL ATILSQFQVS
421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS
>CYP110D2 Nostoc punctiforme
MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW
LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV
GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW
KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF
RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ
GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS
VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE
VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL
VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV
>CYP110D3 Trichodesmium erythraeum
MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT
NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL
LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE
GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA
EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL
YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ
KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS
RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS
WQKVSQPILTSG
>CYP110D4 gi|119486457|
ZP_01620515 Lyngbya sp. PCC 8106
MTLPNGPQTPRVLRMMKFVARPLDYLEDYYRRYGDFIRIGKSATPLVYVNHPAAIEKIFTAGSEQFRTGN
AGGVLLFLLGDNSVLMVDGERHERQRKLLMPPFHGERLKTYNQLICEITKEVMSQVKIGQPFRVRTLMQD
ITLRVILKAVFGLTEGERYEQLRHLLSAMMESIGSPLAASLMFFPSLRQDWGEWSPWGRFLRYKQQADEM
IYAEIRERKQQRDFDGDDILTLLMSARDETGKPMNETELRDELVTLLIAGHETTASSLTWALYWTHYLPE
VKDKLCFELANLGENPHLSEIARLPYLTAVCNETLRIYPVTLTSGVRVLKKPLELGGYSFEPGTVLFPCT
YLVHQREDIYPEPKKFKPERFLQRQFSPYEFFPFGGGHRRCIGSAMATLEMKIALATILSDWQLKLPHHK
AYKPVRRGLTLSPPAQLSLVAVNRLN
>CYP110D5 gi|67920042| ZP_00513562 Crocosphaera watsonii WH 8501
MNLPPTLSQPRLLRLFKLIFYPLDYLEDNYQRYGDIFVAGKSETPFVYISNPQGIQTILTRDKTDFKTGG
GSGFLSTLLGDNSLLFLQGERHRRERKLLMPPFHGERLKSYANLIYSISDKVTDKLQINRSFNVRDIMQE
ITLKVILKAVFGITEGERYQRLQELLKSWLSFFDSPANAILIFFPWLRKNWGNWTPWGRFLQIKAEIQEL
IYTEIRERREQKKYEGTDILTLLMLAKDEEGKPLSDQELHDELITLLIAGHETTASALTWALYWIHFCPD
VEDKLRFHFSNLNNNTDLLDIVKLPYLDAVCKETLRIYPVLLTTFIRVLQTPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSQQFRPERFLERNFSPYEYFPFGGGSRRCIGMELAKMEMKIVLYTILSKHKLKLPSSR
PLKAVRRGLTVAPPSNFKMILSN
>CYP110D6 gi|126654866|
ZP_01726400 Cyanothece sp. CCY0110
MVLPPSISTPRLLRLFKLIFYPLDSLENYYERYGDIFIVGQSETPFVYISNPQGIQEILTKDKTHFRTGG
GSGFLTTFLGNNSLLSLKGEKHQRERKLLTPAFHGERLQSYATLIYSISDEVSEKLEINQSFNVREIMQE
ITLQVILKAVFGIAEGKRYQKLKNLLTSWLSFFDSPINATIIFFPFLQKDWGNWTTWGRFLRIKAQIDDL
IYTEINERRQQKNYQGKDILTLLILARDEDGNPMSDQELHDELITLLIAGHETTASSLTWALYWIHYCPE
VEEKLRSHFSILDKNIDLLNIIKLPYLDAVCSETLRIYPVVVNAFIRVLETPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSKQFRPERFLERQFSPYEYLPFGGGSRRCIGMELAKMEMKIVLFTLLSKYKFKLSSSH
PLKPVRRGLTIAPPNSFKMIITQKLAYT
>CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW
LTNKRPIVFL SNPQAIQELF
61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR
AYGDIITNIT
121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA
VFGLREGERY TQLQKRLCDI LDLSGSALRS