CYP3 clan
(56 sequences in 13 bins)
$$$$$$$
>fgenesh2_pg.scaffold_7000240|Brafl1
41% to CYP3A5 (no allele)
MLELLPLSPTWVLVGVCLVLYYLYLTWPFYTFKRLGIPGPKPVVNFGNILSYTEGSHVFDCKCYKQYGKVFGFFEGRTPM
LMVGDLELIKEITVKQFNNFSNRRDLGSLLEAFAGGLFVIEDTDWKRVRSAISPTFSSSKLKQMSALVEKCADGLVSSLM
EKQEKRVMFDMKELSSAFSMDVISSTAFGVEVDSFKHPDHPFATHAKAIFKINMLKGFFYVMLPPPFNHIFKLRGFSLFP
KFATDFFKQTVHNVIKMRRGNPDDDGLSVVVPCRMTKPSQCLSMTEIVGNSLAFWLAGYDTTANTIALTAYNLAFNQEAQ
DKVREEIDRVVQARGKLDYEALNEMRFLEMCVNETLRIYPGAKRFDRVCKEDIEVKGLHIPAGTIINIPAYAIHHDPEIW
PEPEKFRPERFSKEQQESRDPYAFLPFGSGPRACVGMRLAMLEIKHALAKVLEKFRFVTCEKTEVPLRLENNNGNQVTGG
VWLKVEARTHTPRVRMSSA*
>fgenesh2_pg.scaffold_1716000001|Brafl1
42% to CYP3A27
98% to fgenesh2_pg.scaffold_7000240|Brafl1
MTEIVGNSLAFWLAGYDTTANTIALTAYNLAFNQEAQDKVREEIDRVVQARGKLDYEALNEMRFLEMCVNETLRIYPGA
(gap) 46%
to CYP3A27
KRFSKEQQESRDPYAFLPFGSGPRACVGMRLAMLEIKHALAKVLEKFRFVTCEKTEVPLRLENNNGNQVTGGVWLKVEART
HTPRVRMSSA*
>fgenesh2_pg.scaffold_507000029|Brafl1
42% to CYP3C.b N-term
99% to
fgenesh2_pg.scaffold_7000240|Brafl1
MLELLPLSPTWVLVGVCLVLYYLYLTWPFYTFKRLGIPGPKPVVNFGNILSYTEGSHVFDCKCYKQYGKVFGFFEGRTPM
LMVGDLEIIKEITVKQFNNFSNRRDLGSLLEAFAGGLFVIEDTDWKRVRSAISPTFSSSKLKQMSALVEKCADGLVSSLM
EKQEKRVMFDMKELSSAFSMDVISSTAFGVEVDSFKHPDHPFATHAKAIFKINML
KGFFYVMLPPPFNHIFKLRGFSLFPKFATDFFKQTVHNVIKMRRGNPDDDQESRDPY
60% to
CYP5A danio
AFLPFGSGPRACVGMRLAMLEIKHALAKVLEKFRFVTCEKTE
>estExt_fgenesh2_pg.C_70236|Brafl1
green = 35% to CYP3A5
67% to
fgenesh2_pg.scaffold_7000240|Brafl1
MAAMLHLLPLSPTWVLLGVCLLFYYLYVRRRCILLCSISVPFFVFFCYLTWPFRTFKKLGIPGPKPVLNFGNFLSYKK HI
TNNIISGQHISTNNIISGQHSSANNTISGRTTTTQLPAVLMTTECVEAPVEYRNVPTCVCQRGKQLAADGRTCEDVDECA
LSPPVCGDPSVTHATCENKPGYYLCNCQSGYVMDVDRKACTLNSGGWGPWSDWGPCSKSCDLGMQSRTRVCDSPAPSFGQ
PTCQGSSTGVQMCAENNCPSDATERENAVFLKFKDMPAGEYPMVEAALRAKVSNLVNRYCRGRGAFPICCPEASEDQ GIY
EGRQPILMIGDLGLIKEITVKQFHKFNNRQDLGSILKPFAGSLFVLKDTDWKRVRGAISPTLSSSKLKQMFVLVEKCADG
LVSSLTQGRRALIDMKGCNIYLFCRIFSAYAMDVISSTAFGVDIDALNNPDHPFVTHAKAIFDMNLLKMYLYIMVPPPFN
YLFTLWGFTFFPKFATDFFKHTVERVMKMRQDSADNTERVDFLQLMLKAHNKHRDETANGATLGPGLSKQEIVGNSMIFW
LVGYDTTANTIALTAYNLALSQEAQDRAAGEIHRVVQNRGKLDYEAVHELHYLEMCVNETLRIYPGAKRFDRVCREDADI
NGLHIPAGMNINFPVWVIHHDPELWPEPDKFKPERFSKEEIATRDPYAFLTFGVGPRACVGMRLAMLEIKLALAKVLEKF
RFVTCEKTEDH*
>estExt_fgenesh2_pg.C_7730004|Brafl1
48% to CYP3C.b
81% to
estExt_fgenesh2_pg.C_70236|Brafl1
MAAMLPFLPLSPSWVLLGVCLLLYYLYLTWPFRTFKKLGISGPKPVLNFGNFLSYKKGSHVFDMDCYKKYGKVYGIYEGR
QPILMIGDLGLIKEITVKQFHKFNNRQDLGSILKPFAGSLFVLKDADWKRVRGAISPTLSSSKLKQ ERVDFLQLMLKAHN
KHRDETTSGGTLGHIKLVASTGNRIVDKELDKVIA*
$$$$$$$
>e_gw.406.5.1|Brafl1
37% to CYP3A5 no allele
MFTSVLPRPQGLSNIDLEWMKKYGKYWGVYEGQLPVLIVADTKLIKQINVKEFPNFANRRLMPGNGPVMKYSLTVLQDAE
WKRVRSYMSPFNSAYSLKQLCYLIENTSDNLVAAMKRYHDAGQYVDVKEIFGCYTMDVISSTGFGTDVNSLSDPDSIFIK
NVKKFYAIGALSPFTLLTFGFPWFAFFLDRNNWFFNIVPPPVFNFFADAIRKVISIRESNPAESDKRVDVMQLLLKSHNT
ALDEPGNEGNIKHGLSYNEILANGFIFWIGGYDTTATTISFLAYNLALNPDIQERVIAEIDEIMRGRECMDYKAASEMKY
LKMCVDETLRMYPPSQRFDRQAKEDIDLDGVKIPKGMCVQFSSFAIHYDPDNWPDPEKFDPERFTPEEKKKRDPYAYVAW
GVGPRSCVMKRLGMLEVKFAIAKILMKYRLRPCEKTQIPIRVKVSNLTQPDHGMFLKLEARTDI*
$$$$$$$
>fgenesh2_pg.scaffold_157000010|Brafl1
35% to CYP3A7
no allele
next best match is 52%
MTTDEWNLLSLTYGLLLLFIILFCIYVYRTMSVLRRLGVSGPSPLPFVGNFLTYRKGQRAAFAEWCQKYGRVYRIFEGLN
PKLVVSDLEMVKQILVMDSTSFPFRKPFPLPIGLPAHGLTFAPFIPDHQRVRGVLTPAFSPEKIKMMVPLINKCANHLME
NLEKMCSEGTTFDVKRVFGCFSMDVIASTAFGVDVNSHKNPQDAFVENARKIDITTFTALPPYLVIGGILSYFLPKYVLQ
KLGFAIFPADVVSFFRGVFDDIVDERSKQPPDQRRVDLLELMTRSNEDKIHKHLKDDEGERGVAGLSPDEMFSQVVAVFT
AGYSNSSGLLANTALYLTKNPDVMDKLQREVASDLPTLCQRHDDEVDNRPRRYRSRG*
$$$$$$$$$$
>e_gw.106.108.1|Brafl1
45% to CYP4A11
MWKMLKWGQTDSITLYLCLIILVFRFLRALLWKRYIQKVLAPFPGQPAHWLFGHMREVRPDETGFTIVPQWAAKFKFAFP
LWIGPFRVVLSLVHPDYIKEIVNSPEPKDRVSYAWLKPWIGDGLLVSEGQKWFRNRRLLTPGFHFDVLKPYVKVFSECTN
IMLDRWADLAPGTPVEMFHYASAMTLDSLMRCALSVRSDCQRDSDGSPYIRAVYDLTKCVVERGRFPPFHIPLIFHLSPT
GFRFRKACKTAHDFSDEVIRKRRTELQQQGCHQNDTANSSEDGGKKRYLDFLDILLQARDEDGKGLSEREIRDEVDTFMF
EGHDTTASGVSWILYNLAKHPACQDRCRAEVDAVLQGRAEVKWWDLSKLPYTTMCIKESLRMHSPVPGVTRLTTQPHTFP
DGRSIPAGVSVSIGVHSLHHNIHVWGDNVMEFDPERFSPENSKGRSSHAFIPFSAGSRNCIGQHFAMNELKVTVALTLQR
YRLELDETRPPYRVARLITRTRDGLWLKVYPRGADN*
>fgenesh2_pg.scaffold_785000007|Brafl1
95% to e_gw.106.108.1|Brafl1
MVSIPAQWLPHWETGYLRTACLTVLVAVAVQLVFRFLRALLWKRYIQKVLAPFPGQPAHWLFGHMREVRPDETGFTIVPQ
WAAKFKFAFPLWIGPFRVVLSLVHPDYIKEIVNSPEPKDRVSYAWLKPWIGDGLLVSEGQKWFRNRRLLTPGFHFDVLKP
YVKVFSECTNIMLDRWADLAPGTPVEMFHYASAMTLDSLMRCALSVRSDCQRDSDGSPYIRAVYDLTKCVVERGRFPPFH
IPLIFHLSPTGFRFRKACKTAHDFSDEVIRKRRAELQQQGCHQNDTANSSEDGGKKRYLDFLDILLQARDEDGKGLSERE
IRDEVDTFMFEGHDTTASGVSWILYNLAKHPACQDRCRAEVDAVLQGRAEVKWEDLSKLPYTTMCIKESLRMHSPVPGVT
RLTTQPHTFPDGRSIPAALECIILHHNIHVWGDNVMEFDPKRFSPENSKGRSSHAFIPFSAGSRNCIGQHFAMNELKVTV
ALTLQRYRLELDETRPPYRVARLITRTRDGLWLKVYPRGTDN*
$$$$$$$$$
>estExt_fgenesh2_pg.C_1760080|Brafl1
43% to CYP3A5
MLDLFFFPVTCGLFGLCAVLIYMYLMWPYSTFEDLGIPGPKPLPLFGNYLSYGKSAGEFDRECYKKFNKVYGIFEGRQPI
LMVGDLDLIKDITVKESNNFTNRRVLSGQGEILSKGLTALKDDDWRRFRSTISPAFSSVKLKQMALVIEKYADNFVASLD
KNAKQDVMFNMKELSGAYTMDVISGTAFGVNVDSLHDLNSPFVSNAKDRFNISLFDPFMITISLFPRLGKLLQNLGVTLY
PIKAVEFFRAAVDNVIDMRGRNEDEAKRVDFLQLLLKAHNEELDEEVSKEVISKHGVSKKDIKRESVLFWLGGYETTANT
ISLTTYNLAVHQEVQDKVIQEVDAIIKKHGKLDYDAVNDLHYLDMCVNETLRLFPASQRFERVNKEDTEIRGLKIPAGTI
VNIPAYAIHRDEEIWPDPEDFKPERFSPEEKESRDPYAFLPFGSGPRNCIGMRLAQLELRFALAKALQKFRFVPCDKTVI
PIRIKNTLSNQIEGGVWLKVEARA*
>estExt_fgenesh2_pg.C_1410072|Brafl1
green = 42% to CYP3A4
98% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLRSFKKHVEGLSLEPKPEHSPGKLEEKIFYCKLCCLESTRARAHTFFTFEEGLKHLRNHWKPPKQQRGPPIRRNKVPPE
LYYKQKAVNVEEDITLLAKLYLGFKVQERNPYRCGLCGEVFPTTSNRYHHVEAEHVEVCVPLLCCGAAFQNRDKYIQHMF
FKHCELRIQTGKESLLICKLCFVAFYNRTDLEWHYYRHNQHVDNPTLDSGDGPFPTRSQFFRCTLCSDQCVLSRRKPPVL
YTLSESFSHLGWHWLHQIPPEIRQNPVLMFEDDADIIHKLYMDPVGMQAWQCGICPLQLNKEHVLNYHSEGRRVLRCEGV
TCKNSLQFAKLEDFVGHIFMRHTEVLKLEEMFLCLICNRILCGLIPHSRILESPARSLCRCLGTTYHTERI
FEGRQPILM
VGDLDLIKDITVKESNNFTNRRVLSGQGEILSKGLTALKNDDWRRFRSTISPAFSSVKLKQMALVIEKYADNFVASLDKN
AKQDVMFNMKELSGAYTMDVISGTAFGVNVDSLHDLNSPFVSNAKDRFNISLFDPFMITISLFPRLGKLLQSLGVTLYPI
KAVEFFRAAVDNVIDMRGRNEDEAKRVDFLQLLLKAHNEELDEEVSKEVISKHGVSKKDIKRESVLFWLGGYETTANTIS
LTAYNLAVHQEVQDKVIQEVDAIIKKHGKLDYDAVNDLHYLDMCVNETLRLFPASQRFERVNKEDTEIRGLKIPAGTIVN
IPAYAIHRDEEIWPDPEDFKPERFNQEEKESRDPYAFLPFGSGPRNCIGMRLAQLELRFALAKSLQKFRFVPCDKTMIPI
RIKNTLSNQIEGGVWLKVEART*
>e_gw.7.651.1|Brafl1
69% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLDLLPFSPTWVLVGLCVVLIYLYMVWPYSTFKKLGIPGPKPVLLFGNYLSYRKGGSKFDKECYKKFNKVYGIFEGRHPL
LMVGDLELVKDITVKEFNTFTNSYRRTFEGQEGSVLTVLKDADWKRVRSAISPAFSPGKLKQMEMVVEKCANNFVVNLVE
KAKQGVVFDLKELSGAYTMDVISGTAFGVHLDSLHDRNHPFVANAKKMFDVNLFHPIIIILFLFPPLVKVLQKLGASMFP
REVLDFFSAAVDNVMDMRGSNEDEAKRVDLLQLMLKAHNEELDKEVPKDVVKHGQEIKDNAMLFWLAGYETTADTLSLTA
YNLALHQEAQNKVIEEVDAIVEKRGKLDHDAVNEMPFLEMCVNETLRIFPVNQRFDRVCKEDIEVKGLHIPAGTVVAIPA
YAIHHDPEIWPEPEKFKPERFTKEEKESRDPYAYLPFGSGPRNCVGMRLALMELKFALAKALQKVRFVTCDKTVVSME*
>estExt_fgenesh2_pg.C_70234|Brafl1
55% to CYP3A4
90% to e_gw.7.651.1|Brafl1
MLDLLPFSPTWVLAGLCAVLLYLYMVWPYSTFKKLGIPGPKPVPLFGNYLSYGKGVSKFDKECYKKFNKVYGIFEGRQPI
LIVGDLELVKDITVKEANTFTNRRIFEGQGDIIGNGLTILKDADWKRVRSAISPTFSSGKLKQGKLDYEAVNEMHFLEMC
VNETLRMFPAAQRFDRVCKEDTEVKGLHIPAGTIVNIPAYAIHHDPEIWPEPEKFKPERFSKEEKESRDPYAYLPFGSGP
RNCVGMRLALMELKFALAKALQKVRFVTCDKTVIPIGIKNTLGNQIEGGMWLKVEARS*
>fgenesh2_pg.scaffold_1518000001|Brafl1
44% to CYP3A7
82% to e_gw.7.651.1
MALVVERCGDNFVANLEENAKQGVGFDLKELSGAYTMDVISGTAFGVDVDSLHNPNHPFVAHAKKLFDFNLFNPFVIILC
EYLVSIHVGKVLEKFGVSLFPRKVLNFFSAAVDNVIDMRGSNEDEAKRVDFLQLMLKAHNKELDKEVPKDVVKQGVSKKE
IKGNAVLFWIAGYETTANTISLTAYNLALNQEAQDKVIEEVDAIVEKRGKLDYEAVNEMHFLEMCVNETLRMFPAAQRFD
RVCKEDTEVKGLHIPAGTIVNIPAYAIHHDPEIWPEPEKFKPERFSKEEKESRDPYAYLPFGSGPRNCVGMRLALMELKF
ALAKALQKVRFVTCDKTVIPIGIKNTLGNQIEGGMWLKVEART*
>e_gw.773.9.1|Brafl1
47% to CYP3A27
94% to fgenesh2_pg.scaffold_1518000001|Brafl1
EIKSNAVLFWIAGYETTANTISLTAYNLALHQEAQDKVIEEVDAVIEKRGQLDYEAVNEMPFLEMCVNETLRMFPAAQRF
DRICKEDTEVKGLQIPAGTIINIPAYAIHHDPEIWPEPEKFKPERFSKEEKESRDPYAYLPFGSGPRNCVGMRLALMELK
FALAKALQKVRFVTCDKTVVSHWLDEASSPKAK*
>e_gw.7.15.1|Brafl1
385 to CYP3A5
76% to e_gw.7.651.1|Brafl1
MLDLLPFSPTWVLVGLCAVLLYLYMVWPYSTFNDLGIPGPKPVPLFGNYLSYGQGIAKFDKECYKKFNKVYGIFEGRQPI
LIVGDLELVKDITVKEANTFTNRRVKGQGEFFDGGLLNIKDADWKRVRSAISPTFSSGKLKQMALVVEKCGDNFVANLEN
NAKQGVMFDLKDLSGAFTMDVISGTAFGVDVDSLHDPNHPFVANARKLFDFNLFNPILIVLFLFPQLAKIFSAMGLNMSV
FSTKALEFFGAAVDNVLDMRGSNEEEAAKRVDFLQLMLKAHNEELDKEMPKDVEIKSNAVLFWIAGYETTANTISLTAYN
LALHQEAQDKVIEEVDAVIEKRVSPKSNLTTRTPATTHVTNSNMMAFCATGNNFPPMHQKSSQWCVSFRTHSAKSAPKTA
KMPPAMFSKEEKESRDPYAYLPFGSGPRNCVGMRLALMELKFALAKALQKVRFVTCDKTVVSILLDEASSLKAE
>fgenesh2_pm.scaffold_321000003|Brafl1
41% to CYP3A27
62% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLELLPFSPTWVLVGLCALFLYMYLVWPFSTFKKLGIPGPKPVPLFGHYLEYGKGINIFDQECYQKYNKIYGIFEGRQPI
LMIGDLDLVKAITVKGINTFTNHRDMPGQGEGKHALFFSKDETWKRLRIAMSPAFSSGKLKQLTVHIERCAEGFVSNLAE
DAEHGKVFDVKELCGAFSMDVISSTAFGVEIDSLHNPDHPFVTNAKAIFDISLFNIAFFIMFAFPQLGKFLERFGMTVLP
KKPMKFFSEAVDSVMDMRKTNSGDEKPVDFLQLMLKAHNEELDNKASGEVAKHAGVSKKEIKGNAVLFWVAGYDTTANTL
TLTVYNLAVDQKAQDRAVQEVDAIIAKRGKLDYESVNELTYLEMCINETLRMFPASQRFDRVCKKDTEVNGLHIPEGTIV
TFPVWAIHYDADIWPEPEKFKPERFSKEEKESRDPYAFLPFGAGPRNCLGMRIALLELKFALAKALQKFRFVTCEKTELV
LQDFRTPVGVKYATKQKGPSF*
>estExt_fgenesh2_pg.C_3610051|Brafl1
57% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLALLPVPPTWGLLVGLFPVLFYLFLVWPFSTFKKLGIPGPKPIPLFGNYLDYLKGTNLFDQECYNKYNKVWGIFEAQTP
ILMAGDLKLVKEITVKRTNIFQNRRDLGGRGEIFSASMAALKDADWKRVRGAISPTFSTGKLKQMSPHVEKCANDFVSKL
AENEKEGTMFDMKWISGGYALDVISSTAFGVQVDSLNNPDHPLVTSAKTLFVFNFFNPLILIVFLFPQLAWLLEVCGVSF
MNRKSINYFSEAVDNAISMRKAKQADGASDEARPPDFLQLMIEAHNAELDNGVSKDTFKYGVSKREIKGNAVLFWVAGYE
SSSNILSLTAYNLALHQDVQDKAIEELDAVIRKHGKLDYKAVHELPYMEMCINETLRLYPTALRIDRVCTEDVDIHGVHI
PAGMLCFVPVWTIHHDPDIWPEPEKFRPERFSKEEVEARDPYAYLPWGSGPRNCAGMRIAQLELRFAMAKALEKFRFFPC
EKTEIPVRFKNSFIHQVDGGVWLKVEARAHHA*
>e_gw.7.201.1|Brafl1
42% to CYP3A5
99% to estExt_fgenesh2_pg.C_3610051|Brafl1
(allele)
WILILTSLNINRFLVWPFSTFKKLGIPGPKPIPLFGNYLDYLKGTNLFDQECYNKYNKVWGIFEAQTPILMAGDLKLVKE
ITVKRTNIFQNRRDLGGRGEIFSASMAALKDADWKRVRGAISPTFSTGKLKQMSPHVEKCANDFVSKLAENEKEGTMFDM
KWISGGYALDVISSTAFGVQVDSLNNPDHPLVTSAKTLFVFNFFNPLILIVFLFPQLAWLLEVCGVSFMNRKSINYFSEA
VDNAISMRKAKQADGASDEARPPDFLQLMIEAHNAELDNGVSKDTFKYGVSKREIKGNAVLFWVAGYESSSNILSLTAYN
LALHQDVQDKAIEELDAVIRKHGKLDYKAVHELPYMEMCINETLRLYPTALRIDRVCTEDVDIHGVHIPAGMLCFVPVWT
IHHDPDIWPEPEKFRPERFSKEEVEARDPYAYLPWGSGPRNCAGMRIAQLELRFAMAKALEKFRFFPCEKTEVKS*
>estExt_gwp.C_3530067|Brafl1
61% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLDLLLFSPTWALAGLCAVLLYLYLVWPLSTFKKLGIPNPKPVLLFGNYLEYWKGVNLFDKECYAKYNKVYGYFEGRVPN
LMVGDLEIIKEITVKEINKFTNRRPLPGQGEIFDNSLLGLKDADWKRVRSAITPTFSSGKLKQMAAQIEHCAERLVASLA
ENQKKGTEFDMKHLAGAFTMDVISSTGFGVDVDSLHNPDHPLVTSAKSFFEFNFYDPKAIILFLFPSLFGILERFGITLF
PKKALDYFKEAVDSVISMREGESNGKRPVDLLQLMLQAHNEELDKKHGISSMEFKGNAIILWVVGYETTANTISLTAYNL
AVNQEAQGKVHAEIDALLEKREKLDYDAVHDLPYLDMCISETLRMYPAATRFDRICKEDTEVKGLHIPASMIVSVPVYAI
HHDADLWPEPEKFRPERFTKEEKESRDPYAYLPFGAGPRICVGMRLAQLELKFALAKMLQKFRFVTCDKTVVSEDLRTQ
>estExt_GenewiseH_1.C_70558|Brafl1
80% to
estExt_gwp.C_3530067
MLDLLPFSPTWVLVGLCVVLVYLYMVWPYSTFKKLGIPNPKPYPLFGNYLEYGKGANLFDKECYEKYNKVYGYFEGRTPN
LMVGDLELIKEITVKEINKFTNRRTFDGQGDIFDNALTSLKDTDWKRVRSAITPTFSSGKLKQMAAQVERCADGLVANLA
ENQKTGMEFDMKRLAGAFTMDVISSTGFGVDVDSLHNPDHPLVTSAKSFFEFNFYNPMIIILFLFPSLGGILERLGFTFF
SKKALNYFSEAVDTAVSMRGSEPNGTHGISSIEIKGNAIIMWVAGYETTANTLSLTTYNLALHPEVQEKVHAEIAALLEK
REKLDYEAVNDLPYLDMCISETLRMYPAAQRFDRICKEDTEVKGLHIPAGMIVNIPVYAIHYDAELWPEPEKFKPERSED
EGKSRDPYAYLPFGSGPRNCVGMRLAQLELKFALAKMLQKFRFVTC
>fgenesh2_pg.scaffold_361000050|Brafl1
95% to estExt_GenewiseH_1.C_70558|Brafl1
MALPIVEDVNKDLEGLQALMWLNSPILALHTLLHCWQLNWAEETVWSTASSSSHLPIILKGLCAPPCQSSPDDFVSCSIF
PVSFRDYRDDILLCYCDLYDCVIIYDFTTSLA
GAFTMDVISSTGFGVDVDSLHNPDHPLVTSAKSFFEFNFYNPMIIILF
LFPSLGGILERLGFTFFSKKALNYFSEAVDTAVSMRGSEANGTEK
(gap) 51%
to 3A4
LDYEAVNDLPYLDMCISETLRMYPAAQRFDRICKE
DTEVKGLHIPAGMIVNVPVYAIHYDADLWPEPEKFKPERFTKEEKESRDPYAYLPFGSGPRNCVGMRLAQLELKFALAKM
LQKFRFVTCDKTDIPVRLQNTLGNQIEGGLYLKVEART*
>fgenesh2_pg.scaffold_64000080|Brafl1
61% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLELLPFSPTWVLVGLCALFLYMYLVWPFSTFKKLGIPGPKPVPLFGHYLEYGKGINIFDQECYQKYNKIYGIFEGRQPI
LMIGDLDIVKAITVKGINTFTNHRDMPGQGEGKHALFFSKDETWKRLRIAMSPAFSSGKLKQLTVHIERCAEGFVSNLAE
DAEHGKVFDVKELCGAFSMDVISSTAFGVEIDSLHNPDHPFIKFHAYHCSLFPKVAFPQLGKFLERFGMTVLPKKPMKFF
SEAVDSVMDMRKSNSGDEKPVDFLQLMLKAHNEELDNKASGEVAKQAGVSIKEIKGNAVLFWVAGYDTTANTLTLTAYNL
AVDQEAQDRAVQEVDAIIAKRGKLDYESVNELTYLEMCINETLRMFPASQRFDRVCKEDTEVNGLHIPEGTIVTFPVWAI
HYDADIWPEPEKFKPERFSKKEKESRDPYAFLPFGAGPRNCLGMRIAMLELKFALAKALQKFRFVTCEKTEKFPVLSKFV
QNCG*
>estExt_gwp.C_6870007|Brafl1
60% to estExt_fgenesh2_pg.C_1760080|Brafl1
MLDLLLFSPTWALAGLCAVLLYLYLVWPLSTFKKLGIPNPKPVLLFGNYLEYWKGVNLFDKECYEKYNKVYGYFEGRVPN
LMVGDLEIIKEITVKEINKFTNRREYGLKTCPMQSINGFRYADWKRVRSAITPTFSSGKLKQMAAQIEHCAERLVASLAE
NQKKGTEFDMKHLAGAFTMDVISSTGFGVDVDSLHNPDHPLVTSAKSFFEFNFYDPKAIILFLFPSLFGILERFGITLFP
KKALDYFKEAVDSVISMREGESNGTRPVDLLQLMLQAHNEELDKKHGISSMEFKGNAIILWVVGYETTANTISLTAYNLA
VNQEAQGKVHAEIDALLKKREKLDYDAVHDLPYLDMCISETLRMYPAATRFDRICKEDTEVKGLHIPAGMIVSVPVYAIH
HDAELWPEPEKFKPERFTKEEKESRDPYAYLPFGAGPRICVGMRLAQLELKFALAKMLQKFRFVTCDKTVVSEDLRTQ
$$$$$$$$$$
>fgenesh2_pg.scaffold_226000040|Brafl1
37% to CYP5A1
MGVPGPRPWPVFGDFFGQMIRGFWAPDYQVQMMRQYGEVYGVFSGSNPVLMVSDPEMLREIFVKQFHKFSRRNPEGMTLR
TTPQGRYLINLSGEDWKNVRTTLTPAFSSGKLKLMLEQLNRCANILAETVGESAKTGKPFKARELTGGFTMDAIASTAFG
TEIDSQRNPEDPFVIHGKQGLKFDFKNPVVWLFIFFPKIMKPILEAINWDFFPKKSYKFFESVFDQLMAMRHHGGIERVD
FMQLMANAHKDKGEDDEDMGEVKVQGQRKALTKADVVSNGILFFLAGYDTTSLTMAYTMYNLALNQEAQDDVIREVDDVM
EGKDDIDNEALGQLTYLEMCIMETLRLYPPGANVMTRCCVEDAVVNGLSIPKGMSILVPIQGIHYDPERWPEPKKFIPER
FTKEEREKRNPFHWLPFGAGPRNCIGMRLALMEAKIGLAKVFMKYRILPCAETQVPLKIKKHEVFPAAEDGVMLKATPRD
RSDD*
>e_gw.29.216.1|Brafl1
91% to fgenesh2_pg.scaffold_226000040
MYVNNCFLSLSLLQLLFLAPQRYYIRPLSLFKKMGVPGPRPWPVIGDFFGQMIRGFWAPDYQVQMMRQYGEVYGVFSGSN
PVLMVSDPEMLREIFVKQFHKFSRRNVSWLFTFIVTVSTCVMSLGEDWKNVRTTLTPAFSSGKLKLMLEQLNRCANILAE
KVGESAKTGKPFKARELTGGFTMDAIASTAFGTEIDSQGNPEDPFVIHGKQGLKFDFKNPVVWLFICFPKIMKPILEAIN
WDFFPKKSYKFFESVFDQLMAMRHHGGIERVDFMQLMANAHKEKEEDKEDMGEVKVQADVVSNGILFFLAGYDTTSLTMA
YTMYNLALNQEAQDNVIREVDDVMEGKDDIDNEALGQLTYLEMCIMETLRLYPPGANVMTRCCVEDAVVNGLSIPKGMTI
LVPIQGIHYDPERWPEPKKFIPERFTKEEREKRNPFHWLPFGAGPRNCIGMRLAMMEAKIGLAKVFMKYRILPCAETQVP
LKIKKHEVFPAAEDGVMLKATPRDKSEN*
$$$$$$$$$$
>estExt_fgenesh2_pg.C_230022|Brafl1
33% to CYP3A5
MALEFLPIPLSWVVLIVLPVLFYIHSLFVLLSLSLLLALRRRFLTSVLSCLILWGLLLVDVWLDLNRRRRRQLHHHLRSL
PILQPGLALTTGTTTYCVRPLSMFKKMGVAGPKPYPVIGNMMEFKNGLWDIELQMSRVKEFGGAYGVFGGMRPAYVVTDR
EFLREIFIKQFHNFADRSASTTALEVRPMCRALTDLRGDVWKIVRTTISPSFTGGKLKLMTDILNRCADQLVDNIGTSTR
DGAACDIKELSSAFTMDAIAAVAFGTDINTQETPDHPFVVNAKKAFGMDLKNPLLWVYLILPKITKPIMESLQVSLMPRD
CVNFFSGVLSQLMQQRQAGGEGRVDMMQLMMDAHTMRDEEEGEGGEAGGRTRGRKQALSRDDVLANGIQFILAGYETTAS
TLSFTMYNLATHPDVLDKVIREVDDVMKDRDTVDYEACKKLEYMEMCIMENLRIYPAAPRLARVATADTKIQWLTVPKGM
LMDIPVLPIHYDPERYPEPDKFIPESLPIHYNPERYPEPDKFIPERFSKEERQKRDPCDWLPFGAGPRNCIGMRLAMMEA
KIALAKILRSYRIALAPDMEVPVQLSKYTAFVKPEHGIRITVEPRNSGGD*
>gw.94.110.1|Brafl1
80% to
estExt_fgenesh2_pg.C_230022|Brafl1
LTVTLSYCVRPLSMFKKMGIAGPRPYPVIGNLTEFKTVSVNFDYVSKSNMVVFGGMRPAFVVTDREFLREIFIKQFHNFT
DRSVSSNSVDVRPMCRALADLRGDDWKNIRTTLSPSFTGGKLKLACTNILNSCADQLVDNIGTSTRGGAACDIKELSSAF
TMDAIAAVAFGTDINTQETPDHPFVVNAKKAFSVDLKNPLVWVYLLVPKIVKPIMEGLQVGLVPRDCVNFFSDVFTQLME
QRQAGGEGRVDMMQLMMDAHNMKDEEGEGGEAGALSRDDVLANGFQFILAGYETTASTLSFTMYHLATHPDVLDKVIQEV
DDVMKDRDVVDYEACKKLEYMEMCIMENLRIYPAAPRLARVATADTKIQWLTVPKGMLMDIPVLPIHYDPERYPEPDKFI
PERFSKEERQKRDPCDWLPFGAGPRNCIGMRLAMMEAKIALAKILRSYRI
$$$$$$$$
>estExt_GenewiseH_1.C_4310012|Brafl1
40% to CYP3A4
MDVIARTAFGTEIDSQRNPQDPFVLMGRKAFNVEFSSPILMLFVMFPSIMKPIMEWLNIDLFPRDATSFFYSIFDQLIGL
RQKSAEKGRVDFLQLMMDAHKDADEEEEDGVKSHGQKHALTRDDIVANGFLFFVAGYETTASTMAFALYNFALNQEEQDK
AREEVNNIMMDRDLVDYEAVHEMSYLEMCCMETLRLYPPAPNIGRVVSEEVKVQWLTIPKDMFVLVDVLAIHYDPERWPE
PNKFIPGRFTKEAREKRDPYNWLPFGAGPRNCIGMRLAMMELKVGLAKILMKYRFMTAPDTDIPLKMKKTNQFPLPENGI
RLKVELIDQDEN*
>estExt_gwp.C_3360044|Brafl1
86% to estExt_GenewiseH_1.C_4310012|Brafl1
MALEFLPVPLSWVLLALLAVLFYLYAVRPLWVFKKMGVPGPTPLPLLGNMLTIMNDGIWNPEASRQRVQLYGKVYGIFFG
RSAILTISDPEMLRDIFVKKFHALSNTQVATKPSGRMLINLRGEDWKDVRSTLSPAFSGGKLKMMMPAINTCADQLVQNI
AKFAETGESFDTKEVVRLTSTEVLCAVRTGWTSQLVVLESRCYITPSFLCFRFILESPSLISLFMFPSIMKPILEWLNID
LFPRDATSFFYSIFDQLIGLRQKSAEKGRVDFLQLMMDAHKDADEEEEDALTRDDIVANGFLFFVAGYETTATTMAFALY
NFALNQEEQDKAREEVNKIMENRDLIDYEAVHEMSYLEMCCMETLRLYPPIPNTGRVASEEVKVQWLTIPKDMMVIVPVI
AIHYDPERWPEPKKFIPERFTKEAREKRDPYNWLPFGAGPRNCIGMRLAMMELKVGLAKILMKYRFKTAPDTDVRTELYL
VS*
>estExt_GenewiseH_1.C_4310016|Brafl1
86% to estExt_GenewiseH_1.C_4310012|Brafl1
MALEFLPVPLSWVLLALLAVLFYLYAVRPLWVFKKMGVPGPTPLPLLGNMLTIMNDGIWNPEASRQRVQLYGKVYGIFFG
RSAILTISDPEMLRDIFVKKFHALSNTQTDAVTLDTKPSGRMLINLRGEDWKDVRSTLSPAFSGGKLKMMGPAINTCADQ
LVQNIAKFAETGESFDTKEVLGEFSTRLNAFEARGATGQLVVLESHCYTTPSFPFFRFILESPSLISLFMFPSIMKPILE
WLNIDLFPRDATSFFYGIFDQLIGLRQKSDEKGRVDFLQLMMDAHKDADEEEEDALTRDDIVANGFLFFVAGYETTATSM
AFALYNFALNQEEQDKAREEVNKIMENRDLIDYEAVHEMSYLEMCCMETLRLYPPIPNTGRVASEEVKVQWLTIPKDMMV
IVPVIAIHYDPERWPEPKKFIPERFTKEAREKRDPYNWLPFGAGPRNCIGMRLAMMELKVGLAKILMKYRFMTAPDTDVR
AEL
>e_gw.336.47.1|Brafl1
76% to estExt_GenewiseH_1.C_4310012|Brafl1
YAVHPLWTFKNMGVPGPTPLPFVGTLLRWFKDVSRISCGHSQYGKVYGFFFGRTPTLIISDGEMLREIFVKKFHALTDRQ
TDTLSLDTKPSGRMLINLRSEEWKNVRSTLSPAFSGGKLKMMGPAINTCADQLVQNIAKFAGTGESFDTKKLTGAFTMDV
IARTAFGTEIDSQRNPQDPFVLMGRKAFNVEFSSPILMLFGGSVSMRVLNVEHLVPNACFMYIPLDNINTRVLDSVAKGR
VDFLQLMMDAHKDADEEEEDGVKSHGQKHDDIVANGFLFFVAGYETTASTMAFVMYNFALNQEEQDKAREEVNKIMEDRV
GLLLLLLVQNKKVSNTIVSHYRTWLTMRHIGRVVSEEVKVQWLTIPKDMFVLVDVLAIHYDPERWPEPNKFIPERFTKEA
REKRDPYNWLPFGAGPRNCIGMRLAMMELKVGLAKILMKYRFMTAPDTDVRTELYNS*
$$$$$$$$$
>estExt_fgenesh2_pg.C_1550032|Brafl1
38% to CYP3A7
MACESLPMSVSWGLLAALICLVLLYGYRTMSVLQKLGVRGPTPLPFVGNLLTYRKGQNVAFREWRQKYGRVYGMYEGLAP
KLVITDPEIVKQVFVKDFSNFPMRMPLCIPIGLPEETLIFADFSHHKRRRGILSPAFTAGKVKLMVPLVNRCADFLMENL
DKLFVEETTFDAKQVFSYLTLDVMASTAFGVEVNSQKDPQHAFVVNARKVDLSVVGGMKPSLIIAAVLSMVIPMDVLEKW
GLTVVPADAVSFFHSILETILTMRIKQQPNERRMDLLELMRAAREEHCLDLPEEFEKSLSADEVTTDAISFFLAGYDTIA
GLLGTTAVNLARYPDMQDKLLQEVATVTQEQDYVQNEDIQKMEYLDMFLMETLRMDSGARFPRLCTQDTEISPGLTVPAG
VEVIIDSDSLHIDPEYWPEPGTFIPERF
TKEESNKREPFTFIPFGQGPRTCIGMHLALMATKITLVRILQKYRFVACPGTPKDHGLGFFVRNQWVKLERFDY*
>estExt_fgenesh2_pg.C_4440045|Brafl1
32% to CYP3A27
97% to estExt_fgenesh2_pg.C_1550032|Brafl1
MACESLPMSVSWGLLAAFICLVLLYGYRTMSVLQKLGVRGPTPLPFVGNLLTYRKGQNVAFREWRQNYGRVYGMYEGLAP
KLVITDPEIVKQVFVKDFSNFPMRMPLCIPIGLPEETLIFADFSHHKRRRGILSPAFTAGKVKLMVPLVNRCADFLMENL
DKLFVEETTFDAKQVFSYLTLDVMASTAFGVEVNSQKDPQHAFVVNARKVDLSVVGGMKPSLIIAAVLSMVVPMDVLEKW
GLTVVPADAVSFFHSILETILTMRIKQQPNERRMDLLELMRAAREEHCLDLPEEFEKSLSADEVTTDAISFFLAGYDTIA
GLLGTTAVNLARYSDMQDKLLQEVATVTEEQGYVQNEDIQKMEYLDMFLMETLRMDSGARFPRLCTQDTEISPGLTVPAG
VEVIIDSDSLHIDPEYWPEPETFIPERTSCEN
APGCFIQQNHEDYVTMEPLVDQSEIDVSDIFDFVAESVVRWKDLARKL
ELSEAKIGRTDAEQRGNVKESCIEILETWRLKEGCNATVEQGGGIARDLVAKMGVDDVTVLVEMDDNDLEKARTFFNELD
VEQLETLTITEGSRTTATTGDTDSGGAMSSSGTGDSSAQPRLRTKSGDTLGTSPRPHLAECTKCSAMNEDLQSYLKCSTG
HLICRKCFAEHIQTNPAVSVNCPLCSQDIGPYLKASEHTTKDSVWIFVVDSNLWVQGKKLIGKERKFKVAEDPRIRIDVG
QLSEIVAEGRQVVTGTLYGSEPPKLDTIWKKVRQRGWRVPQPKKRSQFTGKEKQIDNQLGVDVTSLVCKTEEGKRGTVIL
VTGDADVVPVLENILHEPPWKTEIWMWEKSISKEIRSLQQCHPDRMRIEHLDAYSKRLTFTNYTYHINPGKHNQLLTQAI
VFEGVQKQPDSLKMNVKWVKRMEEVCRWPFQYAWIFEDNNDINDLLVVFIKGKDAEGTFRGPDLAEMLDLVKKDPYLHSV
STNVQAYFSYKHSRAMDDSVNICLSNQYSGLTDMYDKVEQLEDEGFHSLEEEKEDETTIQVPFPIHQRGARPHLQQFPVQ
PTYRQPSRPGARQHRPFYHPPVTSQAMTPWSPTTEASGAWIPAPMKNRQSPYRPRYSEHCPRKFNCGRGRHCEYTHTPEE
LDFLKQRPPGLKVYKVKLCDKWKTGYCMSEARACNWAHGEGDASCLRCNCRGHLTDNCPTYM*
$$$$$$$
>estExt_fgenesh2_pg.C_920015|Brafl1
38% to CYP3A43
MALEVLPIPLTWTLLPVLAVLFYLFFNGMTPALVISDAEMMKEIFVKQFHKFTNRQTDSQMINVKPLSRMVFQLLDDDWK
NVRTTLSPAFSSSKLRQMTGAMNSCAEQLVENISSFATTKESFDVRQLTGAFTMDVIARTIFGTEINSQRNPQDPFAINA
KKSSNINFNSPLIWLYLLFPGTMKRICELLDYQLFFPREATDFFNGVMDQLLAMRETDGGKGRVDMLQIMIDAHKEKDED
STDGAKVHGKKQPLTRDDVVANGIGFFNAGYDTVSITLSFLLYHLALDQEIQDKVRQEIHDVTDGESLVDYEAVQKMSYL
EMCVMETLRLYSLVPFLVRVAAEDVQLKDLTIPKGMGVSVPVLAIHYDPARWPEPRKFIPERFTKEEREKRNPYDWMPFG
AGPRNCVGMRLAMMELKVGVAKILMKYRVTTGPDTQVPVKLNKWQQFPTPESPIRLMVEPVE*
>e_gw.285.122.1|Brafl1
32% to CYP3A43
87% to estExt_fgenesh2_pg.C_920015
GMTPVLMISDAEMMKEIFVKQFHKFTNRQMINVKPLSRMVFQLLDDDWKNVRTTLSPAFNSSKLRQVRTLSSIKNEGLIF
TQPLLHFHRPSVALLSAMNGCADQLVENISSFATTKESFDVRQLTGAFTMDVIARTIFGTEINSQRNPEDPFVINAKKSS
NINFNSPLIWLYCKICEFLDYQLFFPREATDFFNGVMDQLLSMRETDGGKGRVDMLQIMIDAHKEKDEDSTDGAKVHGKK
QRMNCSKSICWSLTRDDVVANGIGFFNAGYDTVSITLSFLLYHLALNQEIQDKVRQEIDDVTDGESLVDYEAVQKMSYLE
MCVTETLRLYSLVSGLTRVAAEDVNLKGLTIPKGVGVFVPVVAIHYDPARWTDPRKFIPERLDLYSSSSLQIV*
>estExt_GenewiseH_1.C_290099|Brafl1
95% to
estExt_fgenesh2_pg.C_920015|Brafl1
MALEVLPIPLTWTLLPVLAVLFYLYAVRPLFIFRKMGVPGPTPLPVIGTTYLTAFWGFYNNNISVSDVGPVKGFFNGMTP
ALVISDAEMMKEIFVKQFHKFTNRQTDSQMINVKPLSRMVFQLLDDDWKNVRTTLSPAFSSSKLRQMTGAMNSCAEQLVE
NISSFATTKESFDVRQLTGAFTMDVIARTIFGTEINSQRNPQDPFAINAKKSSNINFNSPLIWLYLLFPGTMKRICEFLD
YQLFFPREATDFFNGVMDQLLSMRETDGGKGRVDMLQIMIDAHKEKDEDSTDGAKAHGKKQHDVVANGIGFFNAGYDTVS
ITLSFLLYHLALDQEIQDKVRQETYQVTDGESQVDYEAVQKMSYLEMCVMETLRLYSLVPFLVRVAAEDVQLKDLTIPKG
MGVSVPVLAIHYDPARWPEPRKFIPERFTKEEREKRNPYDWMPFGAGPRNCVGMRLALMELKVGVAKILMKFRITTGPDT
VVPVKLNKWQQFPTPEIPIRLMVEPVD*
>gw.1094.3.1|Brafl1
46% to CYP5A, 43% to CYP3A27
94% to estExt_GenewiseH_1.C_290099|Brafl1
VDYEAVQKMSYLEMCVMETLRLYSLVPFLVRVAAEDVQLKDLTIPKGMGVSVPVVAIHYDPARWTDPRKFIPERFTKAER
EKRNPYDWLPFGAGPRNCVGMRLALMELKVGVAKILMKYRVTTGPDTVVRL
$$$$$$$$
>e_gw.516.10.1|Brafl1
38% to CYP3A5
MAVDVLPIPLTWVLLGLLVLLLYIYGVRPLSTFKKMGVPGPRPWPVIGNLLDRFRHGIYNPDFQLEISQKYGKVYGHYRG
AATPLLVISDNEMLREVFVKQFHNFSQRIVNRMMTLVNGEEWKNMRSTLSPAFSAGKLKQMTEQVNHCADQLVSNLGEQT
SQGHLTGGFAMDAIASVAFGTDIDSQRNPNDPFVVHAKKAFEGQMKNPLFWLFMFFPWIMKPLLEGLGYNFFPRSTTDFF
YKVLDQLMELRQTTRLDFMQLMLNAHKEPEEEEEDSTLSKDDVVSNGIVFFLAGYDTTATTMAFALYNLAVNQEAQDKVI
QELDEVMREKDQVDHEAVQQMTYLEMCIMETLRLHPPGAIFTTRICTRDTTIQWLKIPKGMTVVVPVLAIHYDPERWPEP
KKFIPERFTAEEREKRDQYDWLPFGAGPRNCIGMRLAMMEAKIGLAKVFMKYRIRTGPDTDVSM
>estExt_gwp.C_5160028|Brafl1
83% to e_gw.516.10.1
MAVDLLPIPLTWVLLGLLVLLLYIYGVRPLSTFKKMGVPGPQPWPLIGNLLDVRHGVYNPDFTLERSQKYGKVYGLYRGA
ATPLLVISDREMLREVFVKQFHNFSTRTGDTQFLRTKPLDCMLSVVNGEKWKSLRSTLSPAFSAGKLKKMSEQLNRCADQ
LVSNLGEQTSQGQSFEAKKLTGDFTMDAIASVAFGTDIDSQRNPNDPFVVHAKKAFEGPFKNPLFWLFLFFPWIMKPLLE
GLGYNFFPRSTADFFYKVLDQLMELRQTTVSVSERLDFMQLMLNAHKEPEEEEEDNSTDVKVQGQKQALTKDDVVSNGIV
FFLAGYDTTATTMAFTLYNLAINQEAQDKVIQELDEVMREKDQVDHEALQQMTYLEMCIMETLRLHPPAALIMTRICTKD
TTIQWLKIPKGMTVLIPVLAIHYDPERWPEPKKFIPERFTAEEREKRDQYDWLPFGAGPRNCIGMRLAMMEAKIGLAKVF
MKYRIRTGLDTDVSRTMLKFNAF*
>e_gw.6.166.1|Brafl1
58% to e_gw.516.10.1|Brafl1
MSADSLPVPLTWILLAILPVLFYIYAVRPLQLFKKMGVPGPAPWPIIGNLLDHMRDGIWNIETQVARTRKYGTVYGMFGG
GFTGVFITDPEMLQDVFVKKFHSFTNRQINVRPAGRMLTSLFDEDWKSVRSTVSPAFSGGKLKQMAGPMNSCADLLIENM
SKFAESGECFEVKELTGAFTMDAITRTAFGTQIDSQKNPDDPFVVYAKKMIDRPISPALLMFMFFPKLMKPIFEKFQVGI
FPTAPTQFFYNVFDQLMEMRETEQERVDFMQLMMNAHKEHDKEPDGSGDKPPLTKDDVVANGILFFIAGYETTATTMAFA
LYNLALNQDVQEKVRQEIEHVMEDKVLVDYEAVHKMSYLEMCILETLRMYPPVSINMRASSEEVKLKWLTIPKGMLVGVP
ILSIHYDPERWPEPYKFIPERFTKEEKEKRGAFDWVPFGSGPRNCIGMRLALFELKLGLARLLMKYRVMTGPDTDVRMGL
ILV*
>estExt_fgenesh2_pm.C_1370013|Brafl1
39% to CYP3A7
77% to e_gw.6.166.1|Brafl1
MAGDSLPIPLTWILLAILPVLFYIYAVRPLQLFKKMSVPGPTPWPIIGNLLDHMKDGVWNIESQVERRKKYGSVYGMYGG
GLTAIFITDPEMLQDIFVKKFHSFTNRQPKDIHLRVKPVGRMLTQLVDEDWKNVRSTISPAFSGGKLKQMAGAMNSCAGL
LVENIGKYADTGESFEVKELTGAFTMDVITRTAFGTQIDSQKNPDDPFVVNARRLIDRPISIFALMFMFFPRLVGSLLER
FQYNLLPADATQFFYSVFDQLMELRQAEGQERVDFLQLMMNAHKEHDKEHDDTGEARQHSHKQPLSKDDVVANGILFFIA
GYETTATTMAFTLYNLALNQDKQDRLRQEITQVMADREFVDNEDVHKMPYLEMCISETLRMYSPAAMTTRASSEEVKLKW
LTIPKDMLVAAPILAIHYDPERWPEPYKFIPERFTKEEKEKRGPYDWMPFGAGPRNCIGMRLALFELKLGLARLLMKYRV
MTAPDTDGGRNSLLAPWS*
>estExt_fgenesh2_pg.C_4700007|Brafl1
35% to CYP3A7
97% to
estExt_fgenesh2_pm.C_1370013|Brafl1
MAVDSLPIPLTWILLAILPVLFYIYAVRPLQLFKKMGVPGPTPWPIIGNLLDHMKDGVWNIESQVKRRKKYGSVYGMYGG
GLTAIFITDPEMLQDIFVKKFHSFTNRQPKDIHLRVKPVGRMLTQLVDEDWKNVRSTISPAFSGGKLKQMAGAMNSCAGL
LVENIGKFADTGESFEVKELTGAFTMDVITRTAFGTQIDSQKNPDDPFVVYARRLIDRPISIFALMFTLTKDDVVANGIL
FFIAGYETTATTMAFTLYNLALNQGKQDKLRQEITQVMADREFVDNEDVHKMPYLEMCISETLRMYSPAAMTTRASSEEV
KLKWLTIPKDMLVAAPILAIHYDPERWPEPYKFIPERFTKEEKEKRGPYDWMPFGAGPRNCIGMRLALFELKLGLARLLM
KYRVMTAPDTDIPLKMKKFKKFPIPENGIRLKVELVDSVTY*
>estExt_gwp.C_3490086|Brafl1
34% to CYP3A27
84% to
e_gw.6.166.1|Brafl1
MSADSLPVPLTWILLAILPVLFYIYAVRPLQLFKKMGVPGPAPWPIIGNLLDHMRDGIWNIESQVARTRKYGTVYGMFGG
GFTGVFITDPEMLQDVFVKKFHSFTNRQTKDLQINVRPAGRMLTSLFDEDWKSVRSTVSPAFSGGKLKQHRKIEPMIKEF
HCCTLKYIVKNVTHKGMMSCCYRLTGAFTMDAITRTAFGTQIDSQKNPDDPFVVYAKKMIDRPISPALLMFMFFPKLMKP
IFEKFQVGIFPLHPPTSSRLSTSQAHRVDSLNYTPLLSGCKLMYPHFSALTKDDVVANGILFFIAGYETTATTMAFALYN
LALNQDVQEKVREEIEHVMEDRVLVDYEAVQKMSYLEMCILETLRMYPPVSINMRASSEEVKLKWLTIPKGMLVGVPILS
IHYDPERWPEPYKFIPERFTKEEKEKRGAFDWVPFGSGPRNCIGMRLALFELKLGLARLLMKYRVMTGPDTDVRMGLILV*
>estExt_gwp.C_860113|Brafl1
83% to e_gw.516.10.1
MAVDLLPIPLAWVLLGLLVLLLYIYGVRPLSTFKKMGVPGPRPWPLIGNVLDVRHGVYNPDFTLERSQKYGKVYGLYRGA
ATPLLVISDREMLREVFVKQFHNFSTRTGETQFLMTKPLDCMLSTVTGEKWKNLRSTLSPAFSAGKLKKMSEQLNRCADQ
LVSNLGEQTSQGQSFEAKKLTGDFTMDAIASVGFGTDIDSQRNPNDPFVVHAKKAFEGPFKNPLFWLFLFFPWIMKPLLE
GLGYNFFPRSTTDFFYKVLDQLMELRQTTVSVGERLDFMQLMLNAHKEPEEEEEDNSRDVKVQGQKQALTKDDVVSNGIV
FFLAGYDTTATTMAFALYNLAINQEAQDKVIQELDEVMREKDQVDHEALQQMTYLEMCIMETLRLHPPAALIMTRICTKD
TTIQWLKIPKGMTVLIPVLAIHYDPERWPEPKKFIPERFTAEEREKRDQYDWLPFGAGPRNCIGMRLALMEAKIGLAKVF
MKYRIRTGPDTDVSMTMLKFNAF*
>e_gw.86.22.1|Brafl1
91% to e_gw.516.10.1
YGVRPLSTFKKMGVPGPRPWPVIGNLLDRFRHGIYNPDFQLEISQKYGKVYGHYRGAAAPLLVISDNEMLREVFVKQFHN
FSQRIVSRETKTKPVDRMMTLVNGEEWKNMRSTLSPAFSAGKLKQMTEQLNHCADQLVSNLGEQTWSQGHLTGGFAMDAI
ASVAFGTDIDSQRNPNDPFVVHAKKAFEGQMKNPLFWLFMFFPWIMKPLLEGLGYNFFPRSTTDFFYKVLDQLMELRQTT
TDTEKLDKYMSLTLYSIFFCSFLSKERLDFMQLMLNAHKEPEEEEEDSSRDVKVQGQKQALTKDDVVSNGIVFFLAGYDT
TATTMAFALYNLAINQEAQDKYQGEVHEVRVYEDQVDHEALQQMTYLEMCIMETLRLHPPGAIFTTRICTKDTTIQWLKI
PKGMTVVIPVLAIHYDPERWPEPKKFIPERFTAEEREKRDQYDWLPFGAGPRNCIGMRLAMMEAKIGLAKVFMKYRIKTG
PDTDVSMIMFNSF*
$$$$$$$
>estExt_GenewiseH_1.C_90137|Brafl1
38% to CYP5A
MELDFLPIPLTWVLLAALSVLFYLYCMRPMNMLKKMGIPHPKPLPVIGNMHQTMKTGVWNPDAQVERINNFGAVYGSYMG
RTVYITISDPEMLREVFVKQFHKFTNRAPDGQSLNIKPSCRMMTQLVDEDWKNVRSTLSPAFSGGKLKQMSEAMNTCADV
LLKNLGKFAEKGESFDSKDLTSGFTTDVIARTAFGLEVDSQGNPEDPFVVYTRKPFAVAFRNPLFWLFFLFPKIMKPILE
FFEYSFLDKDVSSFFYNVVDQVMGMRQTEDKAHRHVDFMQLMMNAHKEDDDDDNKEEGTQVQGIKQPLTRDDIVANGFLF
FIAGYETTATTMGFLLYNLALHQEAQDKAREEINQVMEGRELVDYEAVNKMSYLEMCIHETLRMYSPASGVVRVVGDEVK
MKWLTLKKGMNVMIPILGIHNDPKRWPEPKKFIPERFTKEEREKRDQYDWLPFGAGPRNCIGMRLALMELKVGVARVLRK
YRIVTGPDTDV
>estExt_fgenesh2_pg.C_14420002|Brafl1
99% to estExt_GenewiseH_1.C_90137|Brafl1
MELDFLPIPLTWVLLAALSVLFYLYCMRPMNMLKKMGIPHPKPLPVIGNMHQTMKTGVWNPDAQVERINKFGAVYGSYMG
RTVYITISDPEMLREVFVKQFHKFTNRAPDGQSLNIKPSCRMMTQLVDEDWKNVRSTLSPAFSGGKLKHMSEAMNTCADV
LLKNLGKFAEKGESFDSKDLTSGFTTDVIARTAFGLEVDSQGNPEDPFVVYTRKPFAVAFRNPLFWLFFLFPKIMKPILE
FFEYSFLDKDVSSFFYNVVDQVMGMRQTEDKAHRHVDFMQLMMNAHKEDDDDDNKEEGTQVQGTKQPLTRDDIVANGFLF
FIAGYETTATTMGFLLYNLALHQEAQDKAREEINQVMEGRELVDYEAVNKMSYLEMCIHETLRMYSPASGVVRVVGDEVK
MKWLTLKKGMNVMIPILGIHNDPKRWPEPKKFIPERFTKEEREKRDQYDWLPFGAGPRNCIGMRLALMELKVGVARVLRK
YRIVPGPDTDVRSTIPRGVGPSPDML*
>fgenesh2_pg.scaffold_28000088|Brafl1
71% to estExt_GenewiseH_1.C_90137|Brafl1
MDLDFLPIPLTWVLLAALPVLFYLYAVRPMQALKKLGVSGPTPLPFIGNLHQTMKTGHYNMEAQVEYTAKYGKVYGVFNG
RTPILVISDPEMLREIFVKQFHKFTNRAPKGLSLDVTMQPRMLTQLVDDDWKNVRSTISPAFSGGKLKQMTEAMNSCADL
LVENIGKFGENGESFDTKELTGAFTTDVIARTAFGLEIDSQRNPEDPFVVYSKKALDFNFRNPLVWLFVLFPSIMKPILE
KVNYNFMANDVTDFFYNIVDQVMGMRRNEHGRVDFMQLMMNAHKDDDADMYNDATQDTKVQGTKKPLTKDDIVANSLLFF
LAGYETTATTMAFMLYNLALNQQTQDKAREEINQAMEDRDLVDYEAVHNMPYLDMCINETLRMYSPAANIARAAGEEVKL
KWLTIPKNMLIIIPTLGIHHDPERWPEPEKFIPERFTKEEREKRDPFDWQPFGAGPRNCIGMRLAMMEMKVGLARVLMKY
RFVTGPDTDIPLKIMKYKQFPTPENGIWLRAELLHPGSD*
>fgenesh2_pg.scaffold_143000060|Brafl1
98% to
fgenesh2_pg.scaffold_28000088|Brafl1
MDLDFLPIPLTWVLLAALPVLFYLYAVRPMQALKKLGVSGPTPLPFIGNLHQTLKTGHYNMEAQVEYTAKYGKVYGVFNG
RTPILVISDPEMLREIFVKQFHKFTNRAPKGLSLDVTMQPRMLTQLVDDDWKNVRSTISPAFSGGKLKQRNPEDPFVVYS
KKALDFNFRNPLVWLFVLFPSIMKPILEKVNYNFMANDVTDFFYNIVDQVMGMRRNEHGRVDFMQLMMNAHKDDDADNDA
TQDTKVQGTKKPLTKDDIVANSLLFFLAGYETTATTMAFMLYNMALNQQTQDKAREEINQAMEDRDLVDYEAVHNMPYLD
MCINETLRMYSPAANIARAAGEEVKLKWLTIPKNMLIIIPTLGIHHDPERWPEPEKFIPERFTKEEREKRDPFDWQPFGA
GPRNCIGMRLAMMEMKVGLARVLMKYRFVTGPDTDIPLNIMKYKQFPTPENGIWLRAELLHPESD*
>estExt_fgenesh2_pg.C_720033|Brafl1
38% to CYP3A27
72% to estExt_GenewiseH_1.C_90137|Brafl1
MQALKKLGVSGPTPLPLIGNLHQTMKAGMYNMEAQVEAIAKYGTVYGVFNGRTPLLVISDPQMLREIFVKQFHKFTNRAP
EGMALDVKPQARMLTQLVDDDWKNVRSTISPAFSGGKLKQMTEAMNSCADLLVGNIGNFGEKGESFDTKELTGAFTTDVI
ARTAFGLEIDSQHNPEDPFVVYSKKAFNFNFLNPLIWLFFLFPSIMKPILEKFNYNFMANDVTDFFYNIVDQGRVDFMQL
MVNAHKDDDPDNDATQVPGTKKPLTKDDIVANSFLFFLAGYETTATTMAFTLYNLALHQEAQDKAREEINQVMEDRDLVD
YEAVHNMPYLDMCINETLRMYSPAANNGRVAGEDVKLKWLTIPKNMLVLIPILGIHHDPERWPEPDKFIPERFTKEEREK
RDPFDWQPFGAGPRNCIGMRLALMEMKVGLARVLMKYRIVTGPDTDGLKAF*
$$$$$$
>estExt_fgenesh2_pg.C_560111|Brafl1
35% to
CYP3A4
MALEFCPVPLIWVLLPLLAVLFYVYAVQPLFVFKKMGVPGTGIPPLPIVGTSYTVLLSGIYNTQFTASDFGPVLGVFNGM
NPILIVSDPDMIKEIFVKQFHNFVNRQPEVQDINIMPXSRQVFQLRDEDWKNVRVTLTPAFSGSKLKQV
(gap) 36%
to CYP3A4
VFPNIAK
PLFETFNYHPFTTRDVTDFFYGVMEQLLAMKKTDGGKGRVDLLQIMIDAHQESDDGSTSGPKVVGKRQPLTRDDIVGNGIG
FFSGAFETVSITMSFALYHLALDQEVQDRARQEIREVAGSEGEVGYEAVQKMSYLEMCIMETLRLYPLVSNIQRVANEEARLK
WITVPKGMRVMVPAIAIHYDPARWNEPRKFNPERFTKEEREKRNPMDWLPFGVGPRNCIGMRLALLELKVGLARALMKYR
FVTGPETR
PTRRDQVVCGCLLRSRKTLTGARTVKVQEYMEFGKEITVTHTEVVPVSAEVYWTGFDDYFHLQDFVGMHENM
TTIKGDGGVGTVIEFDFLGGRTQEELVQKDEDTKTWAIAMLGSNPLFTSYLATVKVDEDTSETAKVTMSIKGIVALQDYN
KRKDHIAFTKYMLRNRINEIMAVISEKKGDILPFEFDVDCSFKTLWDMVSDWANVSWVMGATDVEIVPDYQANDLRRKVF
FGSHFMEERHVQTIDHPASTTYEFGKNDTVGVLHYRGKLELIKLDETKTKVKYTSYFTPQPGADPKTTIKALMEPRFDWI
QATFAEKRSLFSSCCLL*
>estExt_gwp.C_560022|Brafl1
84% to estExt_fgenesh2_pg.C_560111|Brafl1
35% to
CYP3A43
MMTLQEFLPVPLTWVLLPLLAVLFYMYAVHPLFVFRKMGVPGIGLPPLPIVGTSYLTILSGIYNTQFSASDFGPVLGVFN
GMNPMLVVTDPDMLKEIFVKQFQNFVNRQSEVQDINIMPQSRQLFQLRDEDWKNVRTQLTPAFSGSKLKQMIAALNSCAD
QLVENLNSFATTKESFDVKEVTGAFSMDVTARTIFGAEVNSQQDPQNPVIAHARRTFNFNFKSPVIWFYVIFPRIAKPIF
ETINYHPFTPRDVTDFFDGVMEQLLAMRKTDGSKGHVDLLQIMIDAHK DMATTKTANIKTQRKFLHLQYCRSKQHFPVISA
LTRDDVVGNGIGFFSGAFETLSITMSFVLYQLALNQEIQDKARQEVNEVVGSEGEVGYEAVQNMSYVEMCVMETLRLYP
LASHIQRVAKEDARLMWINVPKGMNVIVPALAIHYDPKRWNEPRKFIPERFTKEEREKRNPMDWLPFGVGPRNCIGMRLA
LMEMKVGLARALMKYRFVTGPDTVSHM*
>estExt_fgenesh2_pg.C_540178|Brafl1
82% to estExt_fgenesh2_pg.C_560111|Brafl1
MMTLQEFLPIPLTWILLPLLAVLFYMYAVHPLFVFRKMGVPGIGLPPLPIVGTSYLTILSGIYNTQFSASDFGPVLGVFN
GMNPMLVVTDPDMLKEIFVKQFQNFVNRQSEVQDINIMPQSRQLFQLRDEDWKNMRTQLTPAFSGSKLKQMIAALNSCAD
QLVENLNSFATTKESFDVKEVTGAFSMDVTARTIFGAEVNSQQDPQNPVIAHARRTFNFNFKSPVIWFYVLFPRIAKPIF
ETINYHPFTPRDVTDFFDGVMEQLLAMRKTDGSKGHVDLLQIMIDAHK
ESDDGSTDGPKAIGKKQP LTRDDVVGNGIGFF
SGAFETLSITMSFVLYQLALNQEIQDKARQEINEVVGSEGEVDYEAVQNMSYVEMCVMETLRLYPLASHIQRVAKEDARL
MWINVPKGMNVLVPALAIHYDPKRWNEPRKFIPERFTKEEREKRNPMDWLPFGVGPRNCIGMRLALMEMKVGLARVLMKY
RFVTGPDTVPMNLNRWRAFPTPMEPIRLMVEPVD*
>fgenesh2_pg.scaffold_54000181|Brafl1
35% to CYP3C1
83% to
estExt_fgenesh2_pg.C_560111|Brafl1
MMALQEFLPVPLTWVLLPLLAVLFYVYAVHPLFVFKKMGVPGIGFPLPILGTSYVTAHMGVYNPEYSASDFGPVLGVFNG
MNPILIVTDAEMIKEILVKQFHNFVNRQPEVQDINIKPQSRQVFQLRDEDWKNVRVTLTPAFSGSKLKQMMAALNSCADQ
LVENLNSFVTTNESFDVK
(gap) 35%
to CYP3A27
DIAKPIFETINYHPFTPRDVTDFFDGVMEQLLEMRKTDGGKGRVDLLQIMIDAHQESGDEST
NGPKVVGKKQPLTRDDVVGNGIGFFSAAFETLSTSMSFALYQLALDQEVQDKARQEINEVIGSDGEVHYEAVQKMSYLEM
CIMETLRLYPLGASILRVSNEEARLKWVTVPKGMSVVVPALAIHYDPARWNEPRKFIPERFTKEEREKRNPMDWLPFGVG
PRNCIGMRLALLEMKVGLARVLMKYRFVTGPDTVPVKLNKWKVLPVPMEPIPLRVEPLD*
>estExt_gwp.C_560025|Brafl1
36% to CYP3A4
81% to
estExt_fgenesh2_pg.C_560111|Brafl1
MMAIQEFLPVPLTWFLLPLLAVLFYVYAVHPLFVFKKMGVPGIGFPLPIVGTSYQTAQMGVYNPEYSASDFGPVLGVFNG
MNPILIVTDAEMIKEILVKQFHNFVNRQPEVQDINIKPQSRQVFQLRDEDWRNVRVALTPAFSGSKLKQMMAALNSCADQ
LVENLNSFVTTKESFDVKEMTGAFSMDVTARTIFGAEVNSQRDPQNPVIVHAKRAFDFNFKSPLMFLYLMFPSIAKPIFE
TINYHPFTPRDVTDFFDGVMEQLLEMRKTDGGKGRVDLLQIMIDAHQESGDESTNGPKVVGKKQPLTRDDVVGNGIGFFS
AAFETLSTSMSFALYQLALNQEIQDKARQEINEVIGSEGEVDYEAVQKMSYLEMCIMETLRLYPLGASILRVSNEEARLK
WVTVPKGMSVVIPALAIHYDPARWNEPRKFIPERFTKEEREKRNPMDWLPFGVGPRNCIGMRLALLELKVGLARALMKYR
FVTGPDTVSHI*